CN1089539A - 借助切片机生产薄片的方法和装置 - Google Patents
借助切片机生产薄片的方法和装置 Download PDFInfo
- Publication number
- CN1089539A CN1089539A CN93108158.0A CN93108158A CN1089539A CN 1089539 A CN1089539 A CN 1089539A CN 93108158 A CN93108158 A CN 93108158A CN 1089539 A CN1089539 A CN 1089539A
- Authority
- CN
- China
- Prior art keywords
- cutter
- fluid
- thin slice
- flow channel
- liquid basin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 239000012530 fluid Substances 0.000 claims abstract description 96
- 239000007788 liquid Substances 0.000 claims abstract description 80
- 238000007599 discharging Methods 0.000 claims description 37
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims 1
- 238000005520 cutting process Methods 0.000 abstract description 12
- 230000006835 compression Effects 0.000 abstract description 6
- 238000007906 compression Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 230000000875 corresponding effect Effects 0.000 description 12
- 230000008520 organization Effects 0.000 description 10
- 230000014509 gene expression Effects 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 241000628997 Flos Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
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- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
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- 230000003321 amplification Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 229920005989 resin Polymers 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/04—Processes
- Y10T83/0448—With subsequent handling [i.e., of product]
- Y10T83/0453—By fluid application
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/202—With product handling means
- Y10T83/2066—By fluid current
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/202—With product handling means
- Y10T83/2074—Including means to divert one portion of product from another
- Y10T83/2083—Deflecting guide
- Y10T83/2085—Positionable gate in product flow path
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/202—With product handling means
- Y10T83/2092—Means to move, guide, or permit free fall or flight of product
- Y10T83/2096—Means to move product out of contact with tool
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/222—With receptacle or support for cut product
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/647—With means to convey work relative to tool station
- Y10T83/6492—Plural passes of diminishing work piece through tool station
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU925055244A RU2084854C1 (ru) | 1992-07-10 | 1992-07-10 | Способ изготовления микротомных срезов и подготовки их к исследованию и устройство для его осуществления |
RU5,055,244 | 1992-07-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1089539A true CN1089539A (zh) | 1994-07-20 |
CN1036944C CN1036944C (zh) | 1998-01-07 |
Family
ID=21609844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN93108158A Expired - Lifetime CN1036944C (zh) | 1992-07-10 | 1993-07-09 | 借助切片机生产薄片的方法和装置 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5713255A (zh) |
EP (1) | EP0649522B1 (zh) |
JP (1) | JP3271767B2 (zh) |
CN (1) | CN1036944C (zh) |
DE (1) | DE59304829D1 (zh) |
RU (1) | RU2084854C1 (zh) |
WO (1) | WO1994001751A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104977199A (zh) * | 2015-06-15 | 2015-10-14 | 南昌大学 | 漂浮法石蜡切片导流槽 |
CN105842000A (zh) * | 2016-05-06 | 2016-08-10 | 华中科技大学 | 适用于振动切片的自动切片收集装置及方法 |
CN107718221A (zh) * | 2017-09-10 | 2018-02-23 | 徐丽亚 | 用于高级工艺品制作的全自动化象牙果加工装置 |
CN107718222A (zh) * | 2017-09-10 | 2018-02-23 | 徐丽亚 | 自动化象牙果加工设备 |
CN114631011A (zh) * | 2019-10-30 | 2022-06-14 | 莱卡生物系统努斯洛赫有限责任公司 | 刀片架、刀片移动系统和切片机 |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0920613B1 (de) * | 1996-07-29 | 2002-10-02 | Leica Microsystems Nussloch GmbH | Scheiben-mikrotom |
DE19803966B4 (de) * | 1997-03-07 | 2006-05-11 | Microm International Gmbh | Absaugeinrichtung für Schnittabfälle bei einem Kryostat-Mikrotom und Kryostat-Mikrotom |
EP0887635A1 (en) * | 1997-06-23 | 1998-12-30 | Anton Meyer & Co.AG | A knife for cryo-ultramicrotomy |
US6387653B1 (en) * | 1999-04-09 | 2002-05-14 | Culterra, Llc | Apparatus and method for automatically producing tissue slides |
JP3576136B2 (ja) * | 2001-11-30 | 2004-10-13 | 堂阪イーエム株式会社 | 試験片切断装置 |
US7677289B2 (en) * | 2004-07-08 | 2010-03-16 | President And Fellows Of Harvard College | Methods and apparatuses for the automated production, collection, handling, and imaging of large numbers of serial tissue sections |
US7146895B2 (en) * | 2004-10-21 | 2006-12-12 | Kong George Y | Sliding blade microtome |
JP3869453B1 (ja) * | 2005-08-03 | 2007-01-17 | 国立大学法人東京海洋大学 | 薄片製造装置及び薄片製造方法 |
JP5148828B2 (ja) * | 2005-12-28 | 2013-02-20 | サクラファインテックジャパン株式会社 | 薄切片作製装置 |
JP4697707B2 (ja) * | 2006-01-16 | 2011-06-08 | セイコーインスツル株式会社 | 薄切片搬送機構及び薄切片作製装置並びに薄切片の搬送方法 |
JP4636552B2 (ja) * | 2006-01-25 | 2011-02-23 | セイコーインスツル株式会社 | 自動薄切装置 |
JP4548356B2 (ja) * | 2006-02-13 | 2010-09-22 | セイコーインスツル株式会社 | 自動薄切片標本作製装置及び自動薄切片標本作製方法 |
JP4548357B2 (ja) * | 2006-02-13 | 2010-09-22 | セイコーインスツル株式会社 | 自動薄切片標本作製装置及び自動薄切片標本作製方法 |
WO2008066846A2 (en) * | 2006-11-28 | 2008-06-05 | President And Fellows Of Harvard College | Methods and apparatus for providing and processing sliced thin tissue |
US20100000383A1 (en) * | 2007-08-07 | 2010-01-07 | Koos David S | Microscope coupled tissue sectioning system |
JP5002763B2 (ja) * | 2007-11-21 | 2012-08-15 | セイコーインスツル株式会社 | 薄切片作製装置及び薄切片作製方法 |
JP5222541B2 (ja) * | 2007-11-27 | 2013-06-26 | サクラファインテックジャパン株式会社 | 薄切片作製装置 |
DE102008000035B4 (de) * | 2008-01-10 | 2011-02-24 | Leica Biosystems Nussloch Gmbh | Vorrichtung zur Vereinzelung von mit einem Mikrotom angefertigten histologischen Schnitten |
DE102008000262B4 (de) * | 2008-02-08 | 2010-07-01 | Leica Biosystems Nussloch Gmbh | Vorrichtung und Verfahren zum Filtern von in einem Luftstrom befindlichen Schnittabfällen eines Mikrotoms |
JP5102149B2 (ja) * | 2008-08-29 | 2012-12-19 | サクラファインテックジャパン株式会社 | 薄切片作製装置 |
JP2010261794A (ja) * | 2009-05-01 | 2010-11-18 | Seiko Instruments Inc | 薄切片標本作製装置及び薄切片標本作製方法 |
CN102414549B (zh) * | 2009-09-15 | 2013-07-10 | 孔健强 | 切片机 |
WO2012033842A2 (en) | 2010-09-07 | 2012-03-15 | President And Fellows Of Harvard College | Methods, apparatuses and systems for collection of tissue sections |
GB201109999D0 (en) * | 2011-06-14 | 2011-07-27 | Imec | Sample holder |
US8967024B2 (en) * | 2011-07-20 | 2015-03-03 | Vertex Pharmaceuticals, Inc. | Device to collect and segregate tissue samples sectioned on a microtome |
JP5878986B2 (ja) | 2012-11-08 | 2016-03-08 | サクラファインテックジャパン株式会社 | 薄切片作製方法及び薄切片作製装置 |
KR101417515B1 (ko) * | 2012-12-26 | 2014-07-09 | 재단법인 포항산업과학연구원 | 비정질 소재의 권취장치 및 권취방법 |
US9464967B2 (en) | 2014-05-21 | 2016-10-11 | Focus E-Beam Technology (Beijing) Co., Ltd. | Microtomic system and process utilizing electrostatic force to handle sample sections |
EP2806260B1 (de) * | 2013-05-22 | 2016-08-10 | Daniel Dr. Studer | Vorrichtung zur Übertragung von Schnittbändern auf Probenhalter für die Transmissions-Elektronenmikroskopie sowie Verfahren zu deren Verwendung |
US10119889B2 (en) | 2013-12-17 | 2018-11-06 | Aquaro Histology, Inc. | System and method for mounting a specimen on a slide |
US9041922B1 (en) | 2013-12-17 | 2015-05-26 | Alessi Technologies, Inc. | System and method for biological specimen mounting |
EP3076150A1 (en) * | 2015-03-30 | 2016-10-05 | 3Scan Inc. | Methods and apparatuses for sectioning and imaging samples |
US10473557B2 (en) | 2015-06-30 | 2019-11-12 | Clarapath, Inc. | Method, system, and device for automating transfer of tape to microtome sections |
US10571368B2 (en) | 2015-06-30 | 2020-02-25 | Clarapath, Inc. | Automated system and method for advancing tape to transport cut tissue sections |
US10724929B2 (en) | 2016-05-13 | 2020-07-28 | Clarapath, Inc. | Automated tissue sectioning and storage system |
WO2018053473A1 (en) * | 2016-09-19 | 2018-03-22 | Alessi Technologies, Llc | System and method for mounting a specimen on a slide |
US10012567B2 (en) * | 2016-11-14 | 2018-07-03 | Sakura Finetek U.S.A., Inc. | Microtome chuck with light source |
DE102017129537A1 (de) | 2017-12-12 | 2019-06-13 | Karlsruher Institut für Technologie | Mikrotom und Verfahren zum Herstellen von Dünnschnitten aus einer Probe mit Hilfe eines Mikrotoms |
MX2020007709A (es) * | 2020-07-20 | 2022-01-21 | Jesus Raul Beltran Ramirez | Aparato portatil para corte automatico de muestras hitologicas. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2292973A (en) * | 1941-02-06 | 1942-08-11 | Spencer Lens Co | Microtome |
US3103844A (en) * | 1958-10-01 | 1963-09-17 | Lkb Produkter Fabrisaktiebolag | Microtome with illumination and observation means |
US3191476A (en) * | 1962-03-01 | 1965-06-29 | Ames Atomium Inc | Anti-roll device |
US3225639A (en) * | 1964-02-21 | 1965-12-28 | Martinelli Robert | Microtome knife |
AT267217B (de) * | 1967-07-27 | 1968-12-27 | Reichert Optische Werke Ag | Einrichtung zum Justieren des Flüssigkeitsspiegels in Schnittsammelbecken von Ultramikrotomen |
US3552247A (en) * | 1969-07-24 | 1971-01-05 | John E P Pickett | Apparatus and method for direct mounting of microtome tissue specimens |
US3680420A (en) * | 1970-10-22 | 1972-08-01 | Sorvall Inc Ivan | Cryogenic microtome apparatus |
US3667330A (en) * | 1970-12-16 | 1972-06-06 | Devco Inc | Microtome assembly |
US4083277A (en) * | 1976-06-21 | 1978-04-11 | Walter Edward Lotz | Method and means for re-spacing chip steaks on a conveyor |
US4051755A (en) * | 1976-10-07 | 1977-10-04 | Charles F. Kettering Foundation | Ultramicrotome and attachment therefore |
US4447952A (en) * | 1982-12-27 | 1984-05-15 | The United States Of America As Represented By The Secretary Of The Navy | Device for underwater cryogenic cutting |
DE4012600C2 (de) * | 1989-05-26 | 1998-05-14 | Leica Ag | Mikrotom |
-
1992
- 1992-07-10 RU SU925055244A patent/RU2084854C1/ru not_active IP Right Cessation
-
1993
- 1993-07-05 US US08/356,409 patent/US5713255A/en not_active Expired - Lifetime
- 1993-07-05 WO PCT/DE1993/000598 patent/WO1994001751A1/de active IP Right Grant
- 1993-07-05 JP JP50282194A patent/JP3271767B2/ja not_active Expired - Fee Related
- 1993-07-05 EP EP93914604A patent/EP0649522B1/de not_active Expired - Lifetime
- 1993-07-05 DE DE59304829T patent/DE59304829D1/de not_active Expired - Lifetime
- 1993-07-09 CN CN93108158A patent/CN1036944C/zh not_active Expired - Lifetime
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104977199A (zh) * | 2015-06-15 | 2015-10-14 | 南昌大学 | 漂浮法石蜡切片导流槽 |
CN105842000A (zh) * | 2016-05-06 | 2016-08-10 | 华中科技大学 | 适用于振动切片的自动切片收集装置及方法 |
WO2017148449A1 (zh) * | 2016-05-06 | 2017-09-08 | 华中科技大学 | 适用于振动切片的自动切片收集装置及方法 |
CN105842000B (zh) * | 2016-05-06 | 2018-06-22 | 华中科技大学 | 适用于振动切片的自动切片收集装置及方法 |
CN107718221A (zh) * | 2017-09-10 | 2018-02-23 | 徐丽亚 | 用于高级工艺品制作的全自动化象牙果加工装置 |
CN107718222A (zh) * | 2017-09-10 | 2018-02-23 | 徐丽亚 | 自动化象牙果加工设备 |
CN107718221B (zh) * | 2017-09-10 | 2020-07-17 | 安徽昌发实业有限公司 | 用于高级工艺品制作的全自动化象牙果加工装置 |
CN107718222B (zh) * | 2017-09-10 | 2021-06-08 | 徐丽亚 | 自动化象牙果加工设备 |
CN114631011A (zh) * | 2019-10-30 | 2022-06-14 | 莱卡生物系统努斯洛赫有限责任公司 | 刀片架、刀片移动系统和切片机 |
Also Published As
Publication number | Publication date |
---|---|
EP0649522B1 (de) | 1996-12-18 |
JPH08501874A (ja) | 1996-02-27 |
DE59304829D1 (de) | 1997-01-30 |
US5713255A (en) | 1998-02-03 |
JP3271767B2 (ja) | 2002-04-08 |
WO1994001751A1 (de) | 1994-01-20 |
RU2084854C1 (ru) | 1997-07-20 |
CN1036944C (zh) | 1998-01-07 |
EP0649522A1 (de) | 1995-04-26 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: German Waldo Applicant after: Herve Tabone Applicant before: CTL Diehm International |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: CTL DIEHM INTERNATIONAL TO: HERVE TABONE |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: MIKELAMM INTERNATIONAL CO., LTD. Free format text: FORMER OWNER: HERVE TABONE Effective date: 20051118 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20051118 Address after: Wiesbaden, Germany Patentee after: Mike Rohm International Ltd Address before: Waldo, Federal Republic of Germany Patentee before: Herve Tabone |
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C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20130709 Granted publication date: 19980107 |