CN108949503B - Gene detection device applied to biological medicine detection - Google Patents
Gene detection device applied to biological medicine detection Download PDFInfo
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- CN108949503B CN108949503B CN201810875757.3A CN201810875757A CN108949503B CN 108949503 B CN108949503 B CN 108949503B CN 201810875757 A CN201810875757 A CN 201810875757A CN 108949503 B CN108949503 B CN 108949503B
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- 238000001514 detection method Methods 0.000 title claims abstract description 82
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 38
- 239000003814 drug Substances 0.000 title description 4
- 238000012360 testing method Methods 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 50
- 238000013016 damping Methods 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims description 32
- 230000003014 reinforcing effect Effects 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 16
- 230000005540 biological transmission Effects 0.000 claims description 15
- 239000000872 buffer Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 12
- 230000006835 compression Effects 0.000 claims description 10
- 238000007906 compression Methods 0.000 claims description 10
- 238000007599 discharging Methods 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 abstract description 11
- 238000012163 sequencing technique Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 238000004064 recycling Methods 0.000 abstract description 2
- 239000002699 waste material Substances 0.000 abstract description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 239000003351 stiffener Substances 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- 230000035939 shock Effects 0.000 description 7
- 238000006073 displacement reaction Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 101150066838 12 gene Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The invention belongs to the technical field of biomedical detection, and particularly relates to a gene detection device applied to biomedical detection, which aims at the problems that a test tube cannot be cleaned immediately after the existing equipment is used, the cleaning is inconvenient, an object placing table for placing the test tube cannot rotate, the test tube cannot be cleaned completely, and cleaned water cannot be collected for recycling, so that the resource waste is caused, and the design is unreasonable. The device can be cleaned in a rotating way, is convenient and clean to clean, can recycle water, saves resources, ensures the accuracy of gene sequencing, and has stable structure and obvious damping effect.
Description
Technical Field
The invention relates to the technical field of biomedical detection, in particular to a gene detection device applied to biomedical detection.
Background
In the field of biotechnology, gene detection is an important means of life research, and currently, a unimolecular gene sequencing method is generally adopted in gene detection tests, a fluid control device for unimolecular gene sequencing is a key module of a unimolecular tester, a gene chip in the fluid control device for unimolecular gene sequencing is a core component for biochemical reaction and optical imaging, and the fluid control device for gene sequencing is generally provided with a plurality of fluid conveying devices which have functions of conveying various reaction reagents to the gene chip, controlling the flow direction and flow rate of the reagents, controlling the mixing of the reagents, leading out waste liquid and the like.
At present, most of commercial fluid control devices for gene sequencing adopt a negative pressure air pump as a power source, however, a gas-liquid two-phase coexisting closed space exists in a negative pressure air pump system, after the negative pressure air pump stops working, fluid does not stop immediately due to the existence of negative pressure in the closed space, a certain flow is still kept to flow until the air pressure in the last closed space is equal to the atmospheric pressure, so that the gene sequencing is inaccurate, reaction reagents are wasted, a used test tube cannot be cleaned immediately, the cleaning is inconvenient, a placing table for placing the test tube cannot rotate, the test tube is not cleaned completely, a placing plate is not fixed firmly enough, water which cannot be cleaned is collected, the damping effect of equipment is not obvious, the situation of breakage caused by mutual collision is easy to occur, and the vibration can influence the reaction of materials in the test tube, the detection result is affected, and the detection precision is reduced.
Disclosure of Invention
The gene detection device applied to biological medicine detection provided by the invention solves the problems that a used test tube cannot be cleaned immediately and is inconvenient to clean, a placing table for placing the test tube cannot rotate, the test tube cannot be cleaned completely, and cleaned water cannot be collected for recycling, so that the resource is wasted, and the design is unreasonable
In order to achieve the purpose, the invention adopts the following technical scheme:
a gene detection device applied to biological medicine detection comprises a base, wherein four supporting legs are fixedly connected to the lower surface of the base, an outer frame, a fixing seat and a water tank are welded to the upper surface of the base, the outer frame is arranged between the fixing seat and the water tank, the water tank is arranged on the left side of the fixing seat, four lower stand columns are arranged at the inner positions of the upper surface of the base, upper stand columns are arranged above the four lower stand columns, a bottom plate is arranged above the base, the upper stand columns are arranged at the inner position of the lower surface of the bottom plate, a detection box is welded to the upper surface of the bottom plate, two slopes are fixedly connected to the inner bottom position of the detection box, drain pipes are fixedly connected to the low slope sides of the two slopes, an object placing plate is arranged inside the detection box, and a display screen is embedded in the side wall of one side of the fixing seat, the upper surface of fixing base is provided with drawing liquid pump and motor, the motor sets up the left side at the drawing liquid pump, the output shaft welding of motor has the transmission shaft, the transmission shaft runs through the lateral wall of outer frame and detection case and the lateral wall intermediate position fixed connection who puts the thing board, it is provided with the bearing to put one side inside wall of thing board, the transmission shaft rotates with the bearing to be connected, the upper surface of outer frame is provided with the roof, the top of roof is provided with the diaphragm.
Preferably, the upper surface of the upper upright is fixedly connected with two first connecting springs, the lower surface of the bottom plate is provided with four first grooves, the inner side wall of each first groove is fixedly connected with a connecting block, the first connecting springs are arranged in the first grooves, the column wall of the upper upright is symmetrically and fixedly connected with four mounting plates, one side, far away from the upper upright, of the side wall of each mounting plate is welded with a connecting column, the other side of each connecting column is provided with a rotating gear and two stretching springs, one rotating gear is arranged between the two stretching springs, one side, close to the rotating gear, of the side wall of each connecting block is provided with a first arc-shaped groove, a plurality of first sawteeth are uniformly and fixedly connected in the first arc-shaped groove, the rotating gear is meshed with the first sawteeth, and a plurality of vertical rods are uniformly and fixedly connected between the upper upright and the lower upright, it is a plurality of equal two second coupling springs of fixedly connected with between the montant, it is a plurality of the lateral wall of montant all is connected with shock attenuation frame through first round pin axle rotation, shock attenuation frame is connected through second round pin axle rotation by four down tubes, shock attenuation frame's shape structure is square structure.
Preferably, the upper surface of the top plate is uniformly and fixedly connected with a plurality of fourth connecting springs, a plurality of main supporting rods and a plurality of auxiliary supporting rods, the auxiliary supporting rods are arranged between the fourth connecting springs and the main supporting rods, fixing columns are welded on the upper surfaces of the fourth connecting springs, driving gears are arranged at the upper ends of the main supporting rods, driven gears are arranged at the upper ends of the auxiliary supporting rods, and the driven gears are rotatably connected with the driving gears through belts.
Preferably, the upper surface of the object placing plate is uniformly provided with a plurality of test tube placing grooves, test tubes are arranged in the test tube placing grooves, the shape and structure of the test tube placing grooves are matched with the test tubes, rubber anti-slip pads are fixedly connected in the test tube placing grooves, the upper surface of the object placing plate is uniformly and fixedly connected with a plurality of elastic reinforcing rings, the diameter size of the elastic reinforcing rings is smaller than that of the test tubes, the side wall of the object placing plate is provided with two square grooves, the upper side wall and the lower side wall of each square groove are provided with T-shaped sliding grooves, the interiors of the two square grooves are fixedly connected with third connecting springs, one end of each third connecting spring is fixedly connected with the object placing plate, the other end of each third connecting spring is fixedly connected with a fixed block, the upper surface and the lower surface of each fixed block are fixedly connected with a T-shaped sliding block, and the T-shaped sliding blocks are slidably connected in the T-shaped sliding grooves, and a second arc-shaped groove is formed in one side of the side wall of the fixed block, which is far away from the third connecting spring.
Preferably, one side of the outer frame is provided with a reinforcing rod, the reinforcing rod is arranged above the transmission shaft, one end of the reinforcing rod close to the detection box is fixedly connected with a buffer block, one end of the reinforcing rod penetrates through the outer frame and the side wall of the detection box, the buffer block is arranged inside the second arc-shaped groove, one end of the reinforcing rod far away from the detection box is fixedly connected with a rotating handle, the rotating handle is arranged at the outer side of the outer frame, a disc is welded on the surface of the reinforcing rod, a compression spring is fixedly connected with the side wall of the disc, the other end of the compression spring is fixedly connected with the outer frame, the rod wall of the reinforcing rod close to the rotating handle is fixedly connected with a limiting rod, the side wall fixedly connected with stopper of outer frame, the stopper sets up in the below of anchor strut and with the anchor strut contact, the fixed surface of rotatory handle is connected with rubber antiskid cover.
Preferably, the lower surface of the transverse plate is uniformly and fixedly connected with a plurality of detection extraction pipes, the upper surface of the transverse plate is uniformly and fixedly connected with a plurality of extraction hoses, the lower ends of the extraction hoses penetrate through the inside of the transverse plate and are communicated with the corresponding detection extraction pipes, a plurality of through holes are uniformly formed in the top plate, a plurality of detection extraction pipes are arranged in the through holes, the positions and the sizes of the detection extraction pipes correspond to those of the test tubes, the upper ends of the extraction hoses are fixedly connected with hard tubes, the outer surfaces of the hard pipe and the extraction hose are sleeved with a discharge pipe, the inlet end and the outlet end of the liquid pump are fixedly connected with the discharge pipe, one side that outer frame was kept away from to the lateral wall of fixing base is provided with the gene and detects the chip, the upper end and the lower extreme of gene detection chip all are connected with row material pipe, arrange the lower extreme fixedly connected with discharging pipe of material pipe.
Preferably, the middle position in the base is fixedly connected with a water collecting box, and the lower end of the drain pipe penetrates through the upper surface of the base and extends downwards to the inside of the water collecting box.
Preferably, the upper surface of water tank is provided with the suction pump, the play water end of suction pump and the equal fixedly connected with washing water pipe of income water end, wash the upper end and the hard pipe fixed connection of water pipe, wash the pipe wall fixed connection branch pipe of water pipe, the branch pipe runs through diaphragm and roof and downwardly extending to the inside of detection case.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the motor is driven to drive the object placing plate to rotate through the transmission shaft, the bearing ensures the stability of the object placing plate, the object placing plate can rotate 180 degrees, so that the opening of the test tube is downward, the cleaning water in the test tube can be poured out and repeatedly washed for many times, the interior of the test tube and the interior of the detection box can be immediately cleaned, the cleaning is more convenient and cleaner, the cleaned water is collected by the water collecting box through the drainage pipe under the flow guide effect of the slope, the water can be recycled, and the resources are saved.
2. In the invention, the output shaft of the driving motor is fixedly connected with the driving gear, and by driving the driving motor, so that the driving motor drives the driving gear to rotate, the driving gear drives the driven gear to rotate through the belt, and therefore, the height of the fixing column can be adjusted, and then adjust the height of diaphragm, when downwards adjusting, the extraction hose is tensile, make the lower extreme that detects the extraction tube peg graft in the inside of test tube, the upper end that will arrange the material pipe firmly cup joints the inside at the hard pipe, the gas tightness of equipment is good, there is airtight space negative pressure in time, the fluid can not flow detection device's inside yet, guarantee gene sequencing's accuracy, start the drawing liquid pump, the drawing liquid pump carries gene detection chip with the inside reagent of test tube through arranging the material pipe and detects, the result of detection in time shows on the display screen, convenient recording, later the reagent discharges through the discharging pipe.
3. According to the invention, after the cleaning, the object placing plate is reset, the reinforcing rod is pushed inwards, one end of the reinforcing rod and the buffer block are arranged in the square groove, meanwhile, the buffer block pushes the fixing block, the T-shaped sliding block slides in the T-shaped sliding groove, the third connecting spring is compressed, then, the rotating handle is rotated, the limiting rod is in contact with the outer frame, the compression spring is compressed, the object placing plate can be firmly fixed, and the structure of the device is stable.
4. In the invention, in the working process, the equipment is easy to vibrate, the first connecting spring buffers part of vibration, the vibration can drive the equipment to generate a slight displacement effect, the transverse vibration displacement of the equipment can be effectively buffered by arranging the rotating gear, the connecting block, the extension spring and the connecting column, the equipment is prevented from shaking, meanwhile, the second connecting spring, the vertical rod and the damping frame further buffer the vibration, the longitudinal vibration displacement is also effectively reduced, the accuracy of a detection result is ensured, the damping effect of the equipment is obvious, and the situation of crushing caused by mutual impact is not easy to occur.
Drawings
FIG. 1 is a schematic structural diagram of a gene detection device for biomedical detection according to the present invention;
FIG. 2 is a front view of an upper column of the gene testing device for biomedical testing according to the present invention;
FIG. 3 is an enlarged view of the gene testing device for biomedical detection according to the present invention at position A;
FIG. 4 is a schematic structural diagram of a storage plate of the gene testing device for biomedical testing according to the present invention;
FIG. 5 is a schematic structural view of a reinforcing rod of a gene testing device for biomedical testing according to the present invention.
In the figure: 1 base, 2 slopes, 3 upper columns, 4 lower columns, 5 drain pipes, 6 water collecting boxes, 7 bottom plates, 8 outer frames, 9 supporting legs, 10 discharge pipes, 11 display screens, 12 gene detection chips, 13 fixing seats, 14 liquid pumps, 15 motors, 16 discharge pipes, 17 transmission shafts, 18 fixing columns, 19 top plates, 20 transverse plates, 21 extraction hoses, 22 rigid pipes, 23 detection extraction pipes, 24 cleaning water pipes, 25 storage plates, 26 bearings, 27 detection boxes, 28 water pumps, 29 water tanks, 30 first connecting springs, 31 mounting plates, 32 vertical rods, 33 second connecting springs, 34 damping frames, 35 extension springs, 36 connecting columns, 37 rotating gears, 38 connecting blocks, 39 fourth connecting springs, 40 driven gears, 41 driving gears, 42 test tubes, 43 test tube placing grooves, 44 elastic reinforcing rings, 45T-shaped sliding grooves, 46T-shaped sliding blocks, 47 fixing blocks, 48 third connecting springs, 49 square grooves, 50 reinforcing rods, 51 round discs, 52 compression springs, 53 limiting rods and 54 rotating handles.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-5, a gene detection device applied to biomedical detection, comprising a base 1, four support legs 9 fixedly connected to the lower surface of the base 1, an outer frame 8 welded to the upper surface of the base 1, a fixed base 13 and a water tank 29, the outer frame 8 disposed between the fixed base 13 and the water tank 29, the water tank 29 disposed on the left side of the fixed base 13, four lower posts 4 disposed at inner positions of the upper surface of the base 1, upper posts 3 disposed above the four lower posts 4, a bottom plate 7 disposed above the base 1, the upper posts 3 disposed at inner positions of the lower surface of the bottom plate 7, a detection box 27 welded to the upper surface of the bottom plate 7, two slopes 2 fixedly connected to the inner bottom position of the detection box 27, drain pipes 5 fixedly connected to the low slope sides of the two slopes 2, a placement board 25 disposed inside the detection box 27, a display screen 11 embedded in one side wall of the fixed base 13, the upper surface of fixing base 13 is provided with drawing liquid pump 14 and motor 15, and motor 15 sets up the left side at drawing liquid pump 14, and the output shaft welding of motor 15 has transmission shaft 17, and transmission shaft 17 runs through outer frame 8 and detection case 27's lateral wall and puts thing board 25's lateral wall intermediate position fixed connection, and the one side inside wall of putting thing board 25 is provided with bearing 26, and transmission shaft 17 rotates with bearing 26 to be connected, and the upper surface of outer frame 8 is provided with roof 19, and the top of roof 19 is provided with diaphragm 20.
The upper surface of the upper upright post 3 is fixedly connected with two first connecting springs 30, the lower surface of the bottom plate 7 is provided with four first grooves, the inner side wall of each first groove is fixedly connected with a connecting block 38, the first connecting springs 30 are arranged in the first grooves, the post wall of the upper upright post 3 is symmetrically and fixedly connected with four mounting plates 31, one sides of the side walls of the four mounting plates 31, which are far away from the upper upright post 3, are respectively welded with a connecting post 36, the other side of the connecting post 36 is provided with a rotating gear 37 and two stretching springs 35, the rotating gear 37 is arranged between the two stretching springs 35, one side of the side wall of the connecting block 38, which is close to the rotating gear 37, is provided with a first arc-shaped groove, the inner part of the first arc-shaped groove is uniformly and fixedly connected with a plurality of first sawteeth, the rotating gear 37 is meshed with the first sawteeth, and a plurality of vertical rods 32 are uniformly and fixedly connected between the upper upright post 3 and the lower upright post 4, two second connecting spring 33 of equal fixedly connected with between a plurality of montants 32, the lateral wall of a plurality of montants 32 all is connected with shock attenuation frame 34 through first round pin axle rotation, and shock attenuation frame 34 is connected through second round pin axle rotation by four down tube, and the shape structure of shock attenuation frame 34 is square structure.
The even fixedly connected with of upper surface of roof 19 has a plurality of fourth connecting spring 39, a plurality of main tributary vaulting poles and a plurality of auxiliary stay pole, and the auxiliary stay pole setting is between fourth connecting spring 39 and main tributary vaulting pole, and the last skin weld of fourth connecting spring 39 has fixed column 18, and the upper end of main tributary vaulting pole is provided with driving gear 41, and the upper end of auxiliary stay pole is provided with driven gear 40, rotates through the belt between driven gear 40 and the driving gear 41 and is connected.
The upper surface of the object placing plate 25 is uniformly provided with a plurality of test tube placing grooves 43, the inside of each test tube placing groove 43 is provided with a test tube 42, the shape and structure of each test tube placing groove 43 are matched with the test tubes 42, the inside of each test tube placing groove 43 is fixedly connected with a rubber non-slip mat, the upper surface of the object placing plate 25 is uniformly and fixedly connected with a plurality of elastic reinforcing rings 44, the diameter size of each elastic reinforcing ring 44 is smaller than that of each test tube 42, the side wall of the object placing plate 25 is provided with two square grooves 49, the upper side wall and the lower side wall of each square groove 49 are provided with T-shaped sliding grooves 45, the inside of each square groove 49 is fixedly connected with a third connecting spring 48, one end of each third connecting spring 48 is fixedly connected with the object placing plate 25, the other end of each third connecting spring 48 is fixedly connected with a fixed block 47, the upper surface and the lower surface of each fixed block 47 are fixedly connected with a T-shaped sliding block 46, the T-shaped sliding blocks 46 are slidably connected inside the T-shaped sliding grooves 45, a second arc-shaped groove is formed in one side of the side wall of the fixing block 47, which is far away from the third connecting spring 48.
One side of outer frame 8 is provided with stiffener 50, stiffener 50 sets up the top at transmission shaft 17, the one end fixedly connected with buffer block that stiffener 50 is close to detection case 27, the lateral wall of outer frame 8 and detection case 27 is run through to the one end of stiffener 50, the buffer block sets up the inside at the second arc wall, the one end fixedly connected with rotation handle 54 that stiffener 50 kept away from detection case 27, rotation handle 54 sets up the outside at outer frame 8, the skin weld of stiffener 50 has disc 51, the lateral wall fixedly connected with compression spring 52 of disc 51, the other end and the outer frame 8 fixed connection of compression spring 52, the pole wall fixedly connected with gag lever post 53 that stiffener 50 is close to rotation handle 54, the lateral wall fixedly connected with stopper of outer frame 8, the stopper sets up in the below of stiffener 50 and contacts with stiffener 50, the fixed surface of rotation handle 54 is connected with the rubber sliding sheath.
The even fixedly connected with of lower surface of diaphragm 20 detects the extraction tube 23 more, the even fixedly connected with of upper surface of diaphragm 20 a plurality of extraction hoses 21, the lower extreme of a plurality of extraction hoses 21 all runs through diaphragm 20's inside and communicates with a plurality of extraction tubes 23 that detect that correspond, a plurality of through-holes have evenly been seted up to roof 19's inside, a plurality of extraction tubes 23 that detect set up the inside at the through-hole, a plurality of positions and the size that detect extraction tube 23 all correspond with test tube 42, the upper end fixedly connected with hard pipe 22 of a plurality of extraction hoses 21, hard pipe 22 and extraction hose 21's surface has cup jointed row material pipe 16, the entry end and the exit end of drawing liquid pump 14 all with row material pipe 16 fixed connection, one side that outer frame 8 was kept away from to the lateral wall of fixing base 13 is provided with gene detection chip 12, gene detection chip 12's upper end and lower extreme all are connected with row material pipe 16, row material pipe 16's lower extreme fixedly connected with 10.
The inside intermediate position fixedly connected with water collection box 6 of base 1, the lower extreme of drain pipe 5 runs through the upper surface of base 1 and downwardly extending to the inside of water collection box 6.
The upper surface of the water tank 29 is provided with a water suction pump 28, the water outlet end and the water inlet end of the water suction pump 28 are fixedly connected with a cleaning water pipe 24, the upper end of the cleaning water pipe 24 is fixedly connected with a hard pipe 22, the pipe wall of the cleaning water pipe 24 is fixedly connected with a branch pipe, and the branch pipe penetrates through the transverse plate 20 and the top plate 19 and extends downwards to the interior of the detection box 27.
The working principle is as follows: when the device is used, the inside of the water tank 29 is filled with clean water, the top plate 19 moves upwards, the test tube 42 filled with the reagent is placed in the test tube placing groove 43 in the object placing plate 25, the elastic reinforcing ring 44 can firmly fix the test tube 42, the upper surface of the top plate 19 is provided with the driving motor, the output shaft of the driving motor is fixedly connected with the driving gear 41, the driving gear 41 is driven by the driving motor to rotate, the driving gear 41 drives the driven gear 40 to rotate through the belt, so that the height of the fixing column 18 can be adjusted, the height of the transverse plate 20 is adjusted, when the transverse plate is adjusted downwards, the extraction hose 21 is stretched, the lower end of the detection extraction pipe 23 is inserted into the test tube 42, the upper end of the discharge pipe 16 is firmly sleeved inside the hard pipe 22, the air tightness of the device is good, a negative pressure in a closed space exists in time, and the fluid cannot flow into the detection device, the gene sequencing accuracy is ensured, the liquid pump 14 is started, the liquid pump 14 conveys the reagent in the test tube 42 to the gene detection chip 12 through the discharge tube 16 for detection, the detection result is displayed on the display screen 11 in time for convenient recording, then the reagent is discharged through the discharge tube 10, when the interior of the device and the test tube 42 need to be cleaned, the water pump 28 is started, the water in the water tank 29 is conveyed to the interior of the rigid tube 22 and the detection box 27 through the cleaning water tube 24 by the water pump 28, the rigid tube 22, the detection extraction tube 23, the extraction hose 21 and the detection box 27 can be cleaned, the reinforcing rod 50 is pulled outwards, one end of the reinforcing rod 50 and a buffer block are separated from the square groove 49 in the side wall of the object placing plate 25, the compressed compression spring 52 is further compressed at the moment, the limiting rod 53 is far away from the side wall of the outer frame 8, the handle 54 is rotated by arranging the rotating handle 54, the limiting rod 53 is contacted with the limiting block on the side wall of the outer frame 8 and is clamped on one side of the limiting block, so that the object placing plate 25 can rotate, the motor 15 is driven to drive the object placing plate 25 to rotate through the transmission shaft 17, the bearing 26 ensures the stability of the object placing plate 25, the object placing plate 25 can rotate by 180 degrees, so that the opening of the test tube 42 is downward, cleaning water in the test tube 42 can be poured out and can be repeatedly washed, the inside of the test tube 42 and the detection box 27 can be immediately washed, the washing is more convenient and cleaner, the water after being washed is collected by the water collecting box 6 through the drainage pipe 5 under the flow guiding effect of the slope 2, the water can be recycled, the resources are saved, after the object placing plate 25 is completely washed, the reinforcing rod 50 is pushed inwards, one end of the reinforcing rod 50 and the buffer block are arranged in the square groove 49, and the buffer block pushes the fixing block 47, so that the T-shaped slider 46 slides inside the T-shaped chute 45, the third link spring 48 is compressed, and then the turning knob 54 is turned, so that the stopper 53 is brought into contact with the outer frame 8, the compression spring 52 is compressed, the object placing plate 25 can be firmly fixed, the structure of the equipment is stable, the equipment is easy to vibrate in the working process, the first connecting spring 30 buffers part of vibration, the vibration can drive the equipment to generate slight displacement, through the arrangement of the rotating gear 37, the connecting block 38, the extension spring 35 and the connecting column 36, the transverse vibration displacement of the equipment can be effectively buffered, the equipment is prevented from shaking, simultaneously second connecting spring 33, montant 32 and shock attenuation frame 34 are further with vibrations buffering, have also effectively reduced vertical vibrations displacement, guarantee the accuracy nature of testing result, and equipment absorbing effect is obvious, is difficult to strike each other and leads to the broken condition to take place.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (5)
1. The gene detection device applied to biomedical detection comprises a base (1) and is characterized in that four supporting legs (9) are fixedly connected to the lower surface of the base (1), an outer frame (8), a fixed seat (13) and a water tank (29) are welded to the upper surface of the base (1), the outer frame (8) is arranged between the fixed seat (13) and the water tank (29), the water tank (29) is arranged on the left side of the fixed seat (13), four lower stand columns (4) are arranged in the inner portion of the upper surface of the base (1), an upper stand column (3) is arranged above each of the four lower stand columns (4), a bottom plate (7) is arranged above the base (1), the upper stand column (3) is arranged in the inner position of the lower surface of the bottom plate (7), a detection box (27) is welded to the upper surface of the bottom plate (7), and two slopes (2) are fixedly connected to the inner bottom position of the detection box (27), the low slope sides of the two slopes (2) are both fixedly connected with a drain pipe (5), an object placing plate (25) is arranged inside the detection box (27), a display screen (11) is embedded in the side wall of one side of the fixed seat (13), a liquid pump (14) and a motor (15) are arranged on the upper surface of the fixed seat (13), the motor (15) is arranged on the left side of the liquid pump (14), a transmission shaft (17) is welded on an output shaft of the motor (15), the transmission shaft (17) penetrates through the outer frame (8) and the side wall of the detection box (27) and is fixedly connected with the middle position of the side wall of the object placing plate (25), a bearing (26) is arranged on the inner side wall of one side of the object placing plate (25), the transmission shaft (17) is rotationally connected with the bearing (26), a top plate (19) is arranged on the upper surface of the outer frame (8), and a transverse plate (20) is arranged above the top plate (19);
the upper surface of the upper stand column (3) is fixedly connected with two first connecting springs (30), the lower surface of the bottom plate (7) is provided with four first grooves, the inner side wall of each first groove is fixedly connected with a connecting block (38), the first connecting springs (30) are arranged in the first grooves, the column wall of the upper stand column (3) is symmetrically and fixedly connected with four mounting plates (31), one side, far away from the upper stand column (3), of the side wall of each mounting plate (31) is welded with a connecting column (36), the other side of each connecting column (36) is provided with a rotating gear (37) and two stretching springs (35), one rotating gear (37) is arranged between the two stretching springs (35), one side, close to the rotating gear (37), of the side wall of each connecting block (38) is provided with a first arc-shaped groove, and a plurality of first sawteeth are uniformly and fixedly connected in the first arc-shaped groove, the utility model discloses a damping frame, including upper column (3), lower column (4), rotating gear (37), a plurality of montants (32) of even fixedly connected with between upper column (3) and lower column (4), it is a plurality of two second coupling spring (33) of equal fixedly connected with between montant (32), it is a plurality of the lateral wall of montant (32) all rotates through first round pin axle and is connected with damping frame (34), damping frame (34) are connected through second round pin axle rotation by four down tube, damping frame (34)'s shape structure is square structure.
2. The gene testing device applied to the biomedical testing as claimed in claim 1, wherein a plurality of fourth connecting springs (39), a plurality of main supporting rods and a plurality of auxiliary supporting rods are uniformly and fixedly connected to the upper surface of the top plate (19), the auxiliary supporting rods are arranged between the fourth connecting springs (39) and the main supporting rods, the upper surface of the fourth connecting springs (39) is welded with a fixing column (18), the upper end of the main supporting rods is provided with a driving gear (41), the upper end of the auxiliary supporting rods is provided with a driven gear (40), and the driven gear (40) is rotatably connected with the driving gear (41) through a belt.
3. The gene testing device applied to the biomedical detection according to claim 1, wherein a plurality of test tube placing grooves (43) are uniformly formed on the upper surface of the object placing plate (25), test tubes (42) are arranged inside the test tube placing grooves (43), the shape and structure of the test tube placing grooves (43) are matched with the test tubes (42), rubber anti-slip pads are fixedly connected inside the test tube placing grooves (43), a plurality of elastic reinforcing rings (44) are uniformly and fixedly connected on the upper surface of the object placing plate (25), the diameter of the elastic reinforcing rings (44) is smaller than that of the test tubes (42), two square grooves (49) are formed on the side wall of the object placing plate (25), T-shaped sliding grooves (45) are formed on the upper side wall and the lower side wall of each square groove (49), and third connecting springs (48) are fixedly connected inside the square grooves (49), the one end of third connecting spring (48) with put thing board (25) fixed connection, the other end fixedly connected with fixed block (47) of third connecting spring (48), the upper surface and the equal fixedly connected with T shape slider (46) of lower surface of fixed block (47), T shape slider (46) sliding connection is in the inside of T shape spout (45), the second arc wall has been seted up to one side that third connecting spring (48) were kept away from to the lateral wall of fixed block (47).
4. The gene detecting device applied to the biomedical detection according to claim 3, wherein a reinforcing rod (50) is disposed on one side of the outer frame (8), the reinforcing rod (50) is disposed above the transmission shaft (17), a buffer block is fixedly connected to one end of the reinforcing rod (50) close to the detection box (27), one end of the reinforcing rod (50) penetrates through the outer frame (8) and the side wall of the detection box (27), the buffer block is disposed inside the second arc-shaped groove, a rotating handle (54) is fixedly connected to one end of the reinforcing rod (50) far away from the detection box (27), the rotating handle (54) is disposed outside the outer frame (8), a disc (51) is welded to the surface of the reinforcing rod (50), a compression spring (52) is fixedly connected to the side wall of the disc (51), and the other end of the compression spring (52) is fixedly connected to the outer frame (8), the fixing device is characterized in that a limiting rod (53) is fixedly connected to the rod wall of the reinforcing rod (50) close to the rotating handle (54), a limiting block is fixedly connected to the side wall of the outer frame (8), the limiting block is arranged below the reinforcing rod (50) and is in contact with the reinforcing rod (50), and a rubber anti-slip sleeve is fixedly connected to the surface of the rotating handle (54).
5. The gene detection device applied to biomedical detection according to claim 1, wherein a plurality of detection extraction pipes (23) are uniformly and fixedly connected to the lower surface of the transverse plate (20), a plurality of extraction hoses (21) are uniformly and fixedly connected to the upper surface of the transverse plate (20), the lower ends of the plurality of extraction hoses (21) penetrate through the inside of the transverse plate (20) and are communicated with the corresponding plurality of detection extraction pipes (23), a plurality of through holes are uniformly formed in the top plate (19), the plurality of detection extraction pipes (23) are arranged in the through holes, the positions and the sizes of the plurality of detection extraction pipes (23) correspond to the test tubes (42), the upper ends of the plurality of extraction hoses (21) are fixedly connected with hard pipes (22), and the outer surfaces of the hard pipes (22) and the extraction hoses (21) are sleeved with a discharge pipe (16), the entry end and the exit end of drawing liquid pump (14) all with arrange material pipe (16) fixed connection, one side that outer frame (8) were kept away from to the lateral wall of fixing base (13) is provided with gene detection chip (12), the upper end and the lower extreme that gene detection chip (12) all are connected with row material pipe (16), arrange lower extreme fixedly connected with discharging pipe (10) of material pipe (16).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110760146.6A CN113308356A (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
| CN201810875757.3A CN108949503B (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810875757.3A CN108949503B (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110760146.6A Division CN113308356A (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
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| Publication Number | Publication Date |
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| CN108949503A CN108949503A (en) | 2018-12-07 |
| CN108949503B true CN108949503B (en) | 2021-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110760146.6A Withdrawn CN113308356A (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
| CN201810875757.3A Active CN108949503B (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110760146.6A Withdrawn CN113308356A (en) | 2018-08-03 | 2018-08-03 | Gene detection device applied to biological medicine detection |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112094734A (en) * | 2019-06-18 | 2020-12-18 | 广州市汉威信息科技有限公司 | High-throughput gene sequencing device for cancer cell gene mutation research |
| CN113281473B (en) * | 2020-09-29 | 2025-01-10 | 东海县裕隆医学检验实验室有限公司 | Adjustable medical detection device and detection method thereof |
| CN115489863B (en) * | 2022-09-19 | 2023-11-28 | 明科生物技术(杭州)有限公司 | Kit for gene detection and gene detection method |
| CN117405661B (en) * | 2023-12-12 | 2024-04-02 | 深圳市新域景科技有限公司 | Detection equipment and process for chemical agent for metal |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5450004B2 (en) * | 2009-11-30 | 2014-03-26 | 株式会社フジワラテクノアート | Rotating disk making machine |
| CN206236511U (en) * | 2016-12-01 | 2017-06-09 | 中山市科艺电机有限公司 | A damping device for a transformer |
| JP2017136005A (en) * | 2016-02-03 | 2017-08-10 | 東レ株式会社 | Processing apparatus and processing method for analysis chip |
| CN107090402A (en) * | 2017-03-21 | 2017-08-25 | 司硕 | A kind of gene assaying device of technical field of biology |
| CN107345348A (en) * | 2017-08-21 | 2017-11-14 | 江苏广盛源科技发展有限公司 | Cloth cleaning case is used in a kind of fiber cloth processing |
| CN107603851A (en) * | 2017-10-19 | 2018-01-19 | 江苏中通生物科技有限公司 | A kind of biological fermentation equipment being moved easily |
| CN207641970U (en) * | 2017-10-23 | 2018-07-24 | 刘轩 | A kind of chemical test cleans with test tube and dries rack |
-
2018
- 2018-08-03 CN CN202110760146.6A patent/CN113308356A/en not_active Withdrawn
- 2018-08-03 CN CN201810875757.3A patent/CN108949503B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5450004B2 (en) * | 2009-11-30 | 2014-03-26 | 株式会社フジワラテクノアート | Rotating disk making machine |
| JP2017136005A (en) * | 2016-02-03 | 2017-08-10 | 東レ株式会社 | Processing apparatus and processing method for analysis chip |
| CN206236511U (en) * | 2016-12-01 | 2017-06-09 | 中山市科艺电机有限公司 | A damping device for a transformer |
| CN107090402A (en) * | 2017-03-21 | 2017-08-25 | 司硕 | A kind of gene assaying device of technical field of biology |
| CN107345348A (en) * | 2017-08-21 | 2017-11-14 | 江苏广盛源科技发展有限公司 | Cloth cleaning case is used in a kind of fiber cloth processing |
| CN107603851A (en) * | 2017-10-19 | 2018-01-19 | 江苏中通生物科技有限公司 | A kind of biological fermentation equipment being moved easily |
| CN207641970U (en) * | 2017-10-23 | 2018-07-24 | 刘轩 | A kind of chemical test cleans with test tube and dries rack |
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| CN113308356A (en) | 2021-08-27 |
| CN108949503A (en) | 2018-12-07 |
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Denomination of invention: A genetic testing device for biomedical testing Effective date of registration: 20220916 Granted publication date: 20210928 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: Guangzhou Richardson medical laboratory Co.,Ltd. Registration number: Y2022980015384 |
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