CN108888799A - A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance - Google Patents
A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance Download PDFInfo
- Publication number
- CN108888799A CN108888799A CN201810658764.8A CN201810658764A CN108888799A CN 108888799 A CN108888799 A CN 108888799A CN 201810658764 A CN201810658764 A CN 201810658764A CN 108888799 A CN108888799 A CN 108888799A
- Authority
- CN
- China
- Prior art keywords
- cellulose
- nano
- ivermectin
- whisker
- medical dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000001913 cellulose Substances 0.000 title claims abstract description 176
- 229920002678 cellulose Polymers 0.000 title claims abstract description 175
- 150000001875 compounds Chemical class 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims abstract description 86
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims abstract description 86
- 229960002418 ivermectin Drugs 0.000 claims abstract description 86
- 241000894006 Bacteria Species 0.000 claims abstract description 41
- 239000002131 composite material Substances 0.000 claims abstract description 35
- 238000010521 absorption reaction Methods 0.000 claims abstract description 33
- 239000012528 membrane Substances 0.000 claims abstract description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000012530 fluid Substances 0.000 claims abstract description 20
- 239000002609 medium Substances 0.000 claims abstract description 20
- 235000015097 nutrients Nutrition 0.000 claims abstract description 20
- 235000002837 Acetobacter xylinum Nutrition 0.000 claims abstract description 17
- 241001136169 Komagataeibacter xylinus Species 0.000 claims abstract description 17
- 241000235342 Saccharomycetes Species 0.000 claims abstract description 17
- 239000001963 growth medium Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019441 ethanol Nutrition 0.000 claims abstract description 11
- 238000007306 functionalization reaction Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 239000001888 Peptone Substances 0.000 claims description 18
- 108010080698 Peptones Proteins 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- 235000019319 peptone Nutrition 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 9
- 239000002105 nanoparticle Substances 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 6
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 239000000835 fiber Substances 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000013500 performance material Substances 0.000 description 5
- 229920000747 poly(lactic acid) Polymers 0.000 description 4
- 239000004626 polylactic acid Substances 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 230000000507 anthelmentic effect Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 description 2
- 229940030225 antihemorrhagics Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229960001149 dopamine hydrochloride Drugs 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 230000000025 haemostatic effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- HPTYUNKZVDYXLP-UHFFFAOYSA-N aluminum;trihydroxy(trihydroxysilyloxy)silane;hydrate Chemical compound O.[Al].[Al].O[Si](O)(O)O[Si](O)(O)O HPTYUNKZVDYXLP-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 229940021171 curative drug Drugs 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 229910052621 halloysite Inorganic materials 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000002074 melt spinning Methods 0.000 description 1
- 239000002159 nanocrystal Substances 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2301/04—Oxycellulose; Hydrocellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance, includes the following steps：Acetobacter xylinum kind is added in culture medium, saccharomycete is accessed, incubated at room temperature obtains fluid nutrient medium；Ivermectin is added in ethyl alcohol, nano-cellulose whisker is added to after being completely dissolved in heating stirring, after mixing, obtains the nano-cellulose whisker solution of absorption ivermectin；Fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, culture obtains nano-cellulose whisker/bacteria cellulose whisker composite membrane of absorption ivermectin；Nano-cellulose whisker/bacteria cellulose whisker the composite membrane for adsorbing ivermectin is washed through hot water to neutrality, is most arranged afterwards through functionalization, the enhanced compound cellulose medical dressing with disinsectization performance is obtained.Medical dressing prepared by the present invention has excellent mechanical property, antibacterial deinsectization and slow release effect, functional good.
Description
Technical field
The invention belongs to medical composite material technical fields, and in particular to a kind of enhanced compound fibre with disinsectization performance
Tie up plain medical dressing and preparation method thereof.
Background technique
Nano-cellulose is the nanocrystal of cellulose, is that a kind of diameter is fine lower than the nanoscale rigid rod of 100nm
Dimension element.Compared with common non-nanofiber element, since nano-cellulose has high-purity, high-crystallinity, high Young's modulus, height
The characteristics such as intensity and the lightweight of biomaterial, degradable, bio-compatible and the characteristics such as renewable, and surface is contained largely
Hydroxyl be easy to be chemically modified, huge application prospect is shown in medical high-performance composite material.
Biodegradable and absorption polymer nano fibrous membrane materials and its system disclosed in Chinese patent CN 1961974B
Preparation Method and purposes, gelatin and ethyl cellulose/noncrystalline cellulose/hydroxymethyl cellulose/hydroxyethyl cellulose/hydroxypropyl is fine
Dimension other high molecular materials of element/hydroxypropyl methyl cellulose/cellulose acetate, which are dissolved in water or ethanol water, to be formed
Even transparent Polymer Solution forms biodegradable and bioabsorbable macromolecular fibre membrane material through electrostatic spinning, then
Biodegradable and bioabsorbable macromolecular fibre membrane material is placed in ethanol water, addition carbodiimide/glutaraldehyde/
Formaldehyde/diepoxides/divinylsulfone crosslinking agent, crosslinked at low temperature, vacuum drying are obtained biodegradable and biological can be inhaled
Macromolecular fibre membrane material is received, which overcomes the technical issues of aqueous gelatin solution system is not easy spinning, can be prepared into
Gelatin and gelatin-compounded micro/nano fibrous membrane material containing curative drug and/or inorganic strengthening agent, spy is standby to be suitable in hemostatic material
Application in terms of material and tissue engineering bracket material.One kind disclosed in Chinese patent CN 106581729A can quick-acting haemostatic powder height
Toughness medical cotton stick, the high tenacity medical cotton stick are received by particles of polylactic acid, nano-cellulose whisker, polyethylene glycol oxide, galapectite
Mitron, polyethylene glycol, Dopamine hydrochloride and Tris-HCl buffer are constituted, and by particles of polylactic acid and nano-cellulose whisker, are gathered
After ethylene oxide and halloysite nanotubes mixing, tell progress melt spinning after stirring that micron order composite polylactic acid fibre is prepared
Tie up it is spare, then by Dopamine hydrochloride be added Tris-HCl buffer after, be soaked into composite polylactic acid fiber, then will it is compound gather
Acid fiber, which takes out, to be added in the Tris-HCl buffer containing polyethylene glycol, and after treatment is taken out, after being washed, being dried, warp
Opener, spice, combing, lapping obtain can quick-acting haemostatic powder high tenacity medical cotton stick.By the above-mentioned prior art it is found that by Nanowire
It ties up plain whisker and is added in medical composite material the mechanical property for improving medical composite material.The present invention is by nano-cellulose whisker
It is effectively combined, is made every effort on the basis of improving Medical composite dressing mechanical property with anthelmintic ingredient, enhance anthelminthic effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of enhanced compound cellulose Medical coating with disinsectization performance
Material and preparation method thereof, the present invention will be compound as carrier by nano-cellulose and bacteria cellulose, and coat ivermectin, assign
The excellent mechanical property of composite cellulosic material, antibacterial deinsectization and slow release effect are given, it is functional good.
In order to solve the above technical problems, the technical scheme is that：
A kind of preparation method of the enhanced compound cellulose medical dressing with disinsectization performance, includes the following steps：
(1) acetobacter xylinum kind is added in culture medium, accesses saccharomycete, incubated at room temperature 2-3d obtains fluid nutrient medium；
(2) ivermectin is added in ethyl alcohol, nano-cellulose whisker is added to after being completely dissolved in heating stirring, mixes
After closing uniformly, the nano-cellulose whisker solution of absorption ivermectin is obtained；
(3) fluid nutrient medium prepared by step (1) is transferred, the absorption ivermectin of step (2) preparation is added
Nano-cellulose whisker solution, cultivates 3-5d at 30 DEG C, obtains nano-cellulose whisker/bacterial fibers of absorption ivermectin
Plain whisker composite membrane；
(4) nano-cellulose whisker/bacteria cellulose whisker composite membrane of the absorption ivermectin of step (3) preparation is passed through
Hot water is washed to neutrality, is most arranged afterwards through functionalization, and the enhanced compound cellulose medical dressing with disinsectization performance is obtained.
As a preferred embodiment of the above technical solution, in the step (1), culture medium is peptone culture medium, wherein peptone
Content be 10-12g/L.
As a preferred embodiment of the above technical solution, in the step (2), the mass ratio of ivermectin and nano-cellulose whisker
It is 1:1-1.2.
As a preferred embodiment of the above technical solution, in the step (2), the nano-cellulose whisker solution of ivermectin is adsorbed
Solid content be 0.5-3%.
As a preferred embodiment of the above technical solution, in the step (3), the dosage of switching accounts for the 10-15% of system total volume.
As a preferred embodiment of the above technical solution, in the step (3), the nano-cellulose whisker solution of ivermectin is adsorbed
Dosage account for the 8-12% of system total volume.
As a preferred embodiment of the above technical solution, in the step (3), the nano-cellulose whisker of ivermectin/thin is adsorbed
The mass ratio of nano-cellulose whisker and bacteria cellulose whisker is 0.3-0.7 in fungin whisker composite membrane:1.
As a preferred embodiment of the above technical solution, in the step (4), the temperature of hot water washing is 60-80 DEG C.
As a preferred embodiment of the above technical solution, in the step (4), functionalization arranges to be mentioned for attachment gel rubber material, plant
Take one of object or nano particle or different materials.
As a preferred embodiment of the above technical solution, a kind of enhanced compound cellulose Medical coating with disinsectization performance
The enhanced compound cellulose medical dressing with disinsectization performance of the preparation method preparation of material.
Compared with prior art, the invention has the advantages that：
(1) in the enhanced compound cellulose medical dressing prepared by the present invention with disinsectization performance containing ivermectin,
Nano-cellulose whisker and bacteria cellulose, ivermectin be a kind of novel spectrum, efficiently, the pest repellant of low toxicity, safety, will
After ivermectin and the mixing of nano-cellulose whisker, nano-cellulose whisker surface has excellent specific surface area, by Yi Wei bacterium
Element is embedded into the nanometer three-dimensional network of nano-cellulose whisker, then again that the nano-cellulose whisker for adsorbing ivermectin is molten
Liquid is added in the preparation process of bacteria cellulose film as functional agent, adsorbs the nano-cellulose whisker solution of ivermectin
Middle nano-cellulose whisker is identical as the ingredient of bacteria cellulose, has natural compatibility, and a small amount of second present in solution
Alcohol can play the role of that bacteria cellulose is promoted to grow, further, since nano-cellulose whisker surface bifurcated rich in
Structure, being conducive to bacteria cellulose enhances the mechanical property of compound cellulose film in its surface apposition growth, and can be by Yi Wei
Rhzomorph coats wherein well, plays lasting slow-release function during use, and it is excellent to assign compound cellulose medical dressing
Different antibacterial, worm-expelling effect.
(2) preparation method of the invention is simple, and using compound cellulose as carrier, compound cellulose carrier has good
Mechanical property, high water retention property, high moisture-inhibiting performance and good biocompatibility can be maintained particularly suitable as medical carrier
The appropriate humidity of skin surface and temperature prevent bacterium infection, then excellent by cladding ivermectin imparting composite cellulosic material
Antibacterial deinsectization and slow release effect, the healing of skin can be promoted, therefore, medical dressing mechanical property and function prepared by the present invention
Property is excellent, is a kind of medical dressing that functionality is good.
Specific embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative examples and explanation of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 10g/L, according to
The mass ratio of acetobacter xylinum kind and saccharomycete is 1.8:1, saccharomycete is accessed, incubated at room temperature 2d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 50 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 0.5%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 10% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
8%, cultivate 3d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker composite membrane,
In, it is fine to adsorb nano-cellulose whisker and bacterium in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin
The mass ratio for tieing up plain whisker is 0.3:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 60 DEG C of hot water
To neutrality, finally adheres to gel rubber material and arranged through functionalization, obtain the enhanced compound cellulose Medical coating with disinsectization performance
Material.
Embodiment 2：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 12g/L, according to
The mass ratio of acetobacter xylinum kind and saccharomycete is 2:1, saccharomycete is accessed, incubated at room temperature 3d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 60 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 3%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 15% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
12%, cultivate 5d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker composite membrane,
Wherein, nano-cellulose whisker and bacterium in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin are adsorbed
The mass ratio of cellulose whiskers is 0.7:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 80 DEG C of hot water
To neutrality, last attached plant extract is arranged through functionalization, obtains having the enhanced compound cellulose of disinsectization performance medical
Dressing.
Embodiment 3：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 11g/L, according to
The mass ratio of acetobacter xylinum kind and saccharomycete is 1.9:1, saccharomycete is accessed, incubated at room temperature 2.5d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 55 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 1.5%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 13% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
10%, cultivate 3.5d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker it is compound
Film, wherein adsorb in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin nano-cellulose whisker and thin
The mass ratio of fungin whisker is 0.6:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 75 DEG C of hot water
To neutrality, finally adheres to nano particle and arranged through functionalization, obtain the enhanced compound cellulose Medical coating with disinsectization performance
Material.
Embodiment 4：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 10g/L, according to
The mass ratio of acetobacter xylinum kind and saccharomycete is 2:1, saccharomycete is accessed, incubated at room temperature 2d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 60 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 0.5%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 15% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
8%, cultivate 5d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker composite membrane,
In, it is fine to adsorb nano-cellulose whisker and bacterium in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin
The mass ratio for tieing up plain whisker is 0.3:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 80 DEG C of hot water
To neutrality, finally adheres to gel rubber material and arranged through functionalization, obtain the enhanced compound cellulose Medical coating with disinsectization performance
Material.
Embodiment 5：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 12g/L, according to
The mass ratio of acetobacter xylinum kind and saccharomycete is 1.8:1, saccharomycete is accessed, incubated at room temperature 3d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 50 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 3%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 10% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
12%, cultivate 3d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker composite membrane,
Wherein, nano-cellulose whisker and bacterium in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin are adsorbed
The mass ratio of cellulose whiskers is 0.7:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 60 DEG C of hot water
To neutrality, finally adheres to nano particle and arranged through functionalization, obtain the enhanced compound cellulose Medical coating with disinsectization performance
Material.
Embodiment 6：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 10.5g/L, is pressed
It is 1.8 according to the mass ratio of acetobacter xylinum kind and saccharomycete:1, saccharomycete is accessed, incubated at room temperature 3d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 50 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 2.5%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 14% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
10%, cultivate 4.5d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker it is compound
Film, wherein adsorb in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin nano-cellulose whisker and thin
The mass ratio of fungin whisker is 0.6:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 75 DEG C of hot water
To neutrality, last attached plant extract is arranged through functionalization, obtains having the enhanced compound cellulose of disinsectization performance medical
Dressing.
Comparative example：
(1) acetobacter xylinum kind is added in peptone culture medium, wherein wherein the content of peptone is 10.5g/L, is pressed
It is 1.8 according to the mass ratio of acetobacter xylinum kind and saccharomycete:1, saccharomycete is accessed, incubated at room temperature 3d obtains fluid nutrient medium.
(2) ivermectin is added in ethyl alcohol, nano-cellulose is added to after being completely dissolved in heating stirring at 50 DEG C
Whisker obtains the nano-cellulose whisker solution of absorption ivermectin, wherein adsorb the nanometer of ivermectin after mixing
The solid content of cellulose whiskers solution is 2.5%.
(3) fluid nutrient medium is transferred, the nano-cellulose whisker solution of absorption ivermectin is added, wherein turned
The dosage connect accounts for the 14% of system total volume, and the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system total volume
10%, cultivate 4.5d at 30 DEG C, obtain absorption ivermectin nano-cellulose whisker/bacteria cellulose whisker it is compound
Film, wherein adsorb in nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin nano-cellulose whisker and thin
The mass ratio of fungin whisker is 0.6:1.
(4) the nano-cellulose whisker/bacteria cellulose whisker composite membrane for adsorbing ivermectin is washed through 75 DEG C of hot water
To neutrality, the enhanced compound cellulose medical dressing with disinsectization performance is obtained.
Through detecting, the enhanced compound cellulose medical dressing with disinsectization performance of embodiment 1-6 and comparative example preparation
Mechanical property, the result of antibiotic rate and anthelminthic effect it is as follows：
As seen from the above table, the enhanced compound cellulose medical dressing prepared by the present invention with disinsectization performance has excellent
Mechanical property, antibacterial deinsectization and slow release effect.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of preparation method of the enhanced compound cellulose medical dressing with disinsectization performance, which is characterized in that including with
Lower step：
(1) acetobacter xylinum kind is added in culture medium, accesses saccharomycete, incubated at room temperature 2-3d obtains fluid nutrient medium；
(2) ivermectin is added in ethyl alcohol, nano-cellulose whisker is added to after being completely dissolved in heating stirring, and mixing is equal
After even, the nano-cellulose whisker solution of absorption ivermectin is obtained；
(3) fluid nutrient medium prepared by step (1) is transferred, the nanometer of the absorption ivermectin of step (2) preparation is added
Cellulose whiskers solution cultivates 3-5d at 30 DEG C, and the nano-cellulose whisker/bacteria cellulose for obtaining absorption ivermectin is brilliant
It must composite membrane；
(4) by nano-cellulose whisker/bacteria cellulose whisker composite membrane of the absorption ivermectin of step (3) preparation through hot water
Washing most arranges afterwards through functionalization to neutrality, obtains the enhanced compound cellulose medical dressing with disinsectization performance.
2. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (1), culture medium is peptone culture medium, and wherein the content of peptone is 10-12g/L.
3. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (2), the mass ratio of ivermectin and nano-cellulose whisker is 1:1-1.2.
4. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (2), the solid content for adsorbing the nano-cellulose whisker solution of ivermectin is 0.5-
3%.
5. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (3), the dosage of switching accounts for the 10-15% of system total volume.
6. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (3), the dosage for adsorbing the nano-cellulose whisker solution of ivermectin accounts for system totality
Long-pending 8-12%.
7. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (3), nano-cellulose whisker/bacteria cellulose whisker composite membrane of ivermectin is adsorbed
The mass ratio of middle nano-cellulose whisker and bacteria cellulose whisker is 0.3-0.7:1.
8. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (4), the temperature of hot water washing is 60-80 DEG C.
9. a kind of preparation side of enhanced compound cellulose medical dressing with disinsectization performance according to claim 1
Method, it is characterised in that：In the step (4), functionalization is arranged as in attachment gel rubber material, plant extracts or nano particle
One or several kinds of materials.
10. a kind of preparation method of the enhanced compound cellulose medical dressing with disinsectization performance described in claim 1-9
The enhanced compound cellulose medical dressing with disinsectization performance of preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810658764.8A CN108888799A (en) | 2018-06-25 | 2018-06-25 | A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810658764.8A CN108888799A (en) | 2018-06-25 | 2018-06-25 | A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108888799A true CN108888799A (en) | 2018-11-27 |
Family
ID=64345781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810658764.8A Withdrawn CN108888799A (en) | 2018-06-25 | 2018-06-25 | A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108888799A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113174701A (en) * | 2021-04-26 | 2021-07-27 | 泉州师范学院(石狮)生态智能织物工程技术研究院 | Preparation method of polyacrylonitrile-based electrospinning reinforced membrane material |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102206355A (en) * | 2011-03-28 | 2011-10-05 | 东华大学 | Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof |
| CN102552965A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Method for preparing nano-cellulose antibacterial composite material through on-line culture |
| CN103418018A (en) * | 2013-07-29 | 2013-12-04 | 南通大学 | Tea fungus synthesized bacterial cellulose pressure sore dressing as well as preparation method and application thereof |
| CN103893816A (en) * | 2014-02-24 | 2014-07-02 | 钟春燕 | Method for preparing composite amniotic extracellular matrix dressing of bacterial cellulose containing plant ingredients |
| CN105189531A (en) * | 2013-03-13 | 2015-12-23 | 新科蒂斯公司 | Peptides for skin rejuvenation and methods of using the same |
-
2018
- 2018-06-25 CN CN201810658764.8A patent/CN108888799A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102206355A (en) * | 2011-03-28 | 2011-10-05 | 东华大学 | Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof |
| CN102552965A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Method for preparing nano-cellulose antibacterial composite material through on-line culture |
| CN105189531A (en) * | 2013-03-13 | 2015-12-23 | 新科蒂斯公司 | Peptides for skin rejuvenation and methods of using the same |
| CN103418018A (en) * | 2013-07-29 | 2013-12-04 | 南通大学 | Tea fungus synthesized bacterial cellulose pressure sore dressing as well as preparation method and application thereof |
| CN103893816A (en) * | 2014-02-24 | 2014-07-02 | 钟春燕 | Method for preparing composite amniotic extracellular matrix dressing of bacterial cellulose containing plant ingredients |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113174701A (en) * | 2021-04-26 | 2021-07-27 | 泉州师范学院(石狮)生态智能织物工程技术研究院 | Preparation method of polyacrylonitrile-based electrospinning reinforced membrane material |
| CN113174701B (en) * | 2021-04-26 | 2023-06-02 | 泉州师范学院(石狮)生态智能织物工程技术研究院 | Preparation method of polyacrylonitrile-based electrospun reinforced membrane material |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fu et al. | Present status and applications of bacterial cellulose-based materials for skin tissue repair | |
| Nicu et al. | Advanced functional materials based on nanocellulose for pharmaceutical/medical applications | |
| Zhang et al. | Using in situ dynamic cultures to rapidly biofabricate fabric-reinforced composites of chitosan/bacterial nanocellulose for antibacterial wound dressings | |
| Silvestre et al. | Do bacterial cellulose membranes have potential in drug-delivery systems? | |
| Wei et al. | Nanocellulose based hydrogel or aerogel scaffolds for tissue engineering | |
| Kalia et al. | Cellulose‐based bio‐and nanocomposites: a review | |
| Chopra et al. | Bacterial nanocellulose based wound dressings: current and future prospects | |
| CN101224310A (en) | A medical wound dressing loaded with antibacterial drug nanoparticles | |
| CN106110371A (en) | A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber wound dressing | |
| CN102552965A (en) | Method for preparing nano-cellulose antibacterial composite material through on-line culture | |
| CN104963094A (en) | Non-woven cloth prepared by composite fibers by means of bacterial cellulose produced by microorganisms and preparation method thereof | |
| CN115154642B (en) | Bionic asymmetric sponge dressing and preparation method thereof | |
| CN113476660A (en) | Preparation method of highly-bionic composite scaffold simulating tendon-bone interface | |
| Liu et al. | Biomedical applications of bacterial cellulose based composite hydrogels | |
| CN105288702A (en) | Acellular polysaccharide dermal matrix materials and production method and application thereof | |
| Peng et al. | In vitro and in vivo study of novel antimicrobial gellan–polylysine polyion complex fibers as suture materials | |
| CN107929794A (en) | A kind of cellulose chitosan combine dressing based on chemical crosslinking and preparation method thereof | |
| Bao et al. | A berberine-loaded electrospun poly-(ε-caprolactone) nanofibrous membrane with hemostatic potential and antimicrobial property for wound dressing | |
| Halib et al. | Nanocellulose: Insight into health and medical applications | |
| Masek et al. | Technological limitations in obtaining and using cellulose biocomposites | |
| Bacakova et al. | Tissue Engineering and Wound Healing Based on Nature-Derived | |
| CN107137748A (en) | A kind of nucleocapsid electrostatic spinning chitosan nano fiber wound dressing and preparation method thereof | |
| Eftekhari-Pournigjeh et al. | Three-dimensional biomimetic reinforced chitosan/gelatin composite scaffolds containing PLA nano/microfibers for soft tissue engineering application | |
| Bal-Öztürk et al. | Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration | |
| CN107737364A (en) | A kind of wound dressing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181127 |