CN108883025A - patch product - Google Patents
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- CN108883025A CN108883025A CN201780021397.4A CN201780021397A CN108883025A CN 108883025 A CN108883025 A CN 108883025A CN 201780021397 A CN201780021397 A CN 201780021397A CN 108883025 A CN108883025 A CN 108883025A
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- Prior art keywords
- patch
- packaging bag
- layer
- coffee
- product
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of patch product, with packaging bag and be accommodated in inside the packaging bag containing receive furan draw coffee patch, the patch product have make the oxygen concentration in packaging bag and/or the construction of moisture content reduction.Furan of receiving as a result, draws the ageing stability of coffee excellent.
Description
Technical field
The present invention relates to a kind of patch products being made of percutaneous patch and packaging bag.
Background technique
The compound of pruritus as pruritus and improvement patients with chronic liver for improving hemodialysis patients,
The furan of receiving for being known as κ type opioid receptor agonist compound draws coffee.
Although hemodialysis patients and the pruritus of patients with chronic liver are not the complication of threat to life, mostly occur and sleeping
Shi Erhui causes sleep disturbance etc., brings obstacle in daily life, to become the QOL (Quality for influencing dialysis patient
Of Life, quality of life) maintenance the complication that can not be despised.
In the medication of medicament, oral medicine is method most typically, but receive furan draw coffee oral medicine be considered to have mistake
It sleeps, constipation and the side effects such as drowsiness, since the occurrence rate of side effect increases with the increase of dosage, therefore, it is considered that in blood
It is temporary receive furan draw coffee concentration rising may be the reason of side effect occur.Therefore, as inhibiting to become side effect
The reason of temporary blood concentration rising and by blood concentration for a long time maintain certain level receive furan draw coffee agent
Type, it is thus proposed that a kind of patch (patent document 1).
In addition, as containing receive furan draw coffee patch improvement, it is thus proposed that a kind of furan of receiving improved in patch draws coffee
Ageing stability patch (patent document 2~4).As improve these patches in receive furan draw coffee ageing stability structure
It makes, proposes the method (patent document 2) that specific tackifying resin is used for adhesive layer, draw coffee using the furan of receiving of free form
Method (patent document 3), and the method (patent document of coffee or its salt and specific adhesive is drawn using the furan of receiving of free form
4)。
Patent document 1：Japanese Unexamined Patent Publication 2013-147459 bulletin
Patent document 2：Japanese Unexamined Patent Publication 2014-196279 bulletin
Patent document 3：International Publication No. 2015/025766
Patent document 4：International Publication No. 2015/025767.
Summary of the invention
As described above, before this, as improve in patch receive furan draw coffee ageing stability means, general means
It is to be conceived to draw ingredient in the patch of coffee containing receiving furan, studies group between ingredient and each ingredient included in patch
It closes.
On the other hand, if can by the means in addition to above-mentioned means improve in patch receive furan draw coffee through when stablize
Property, then without using extra ingredient, therefore it is advantageous from containing to receive for furan draws this angle of the manufacture of patch of coffee.
However, according to known to the present inventor, also not it is proposed that in order to improve in patch receive furan draw coffee ageing stability and
Be conceived to for store contain receive furan draw coffee patch packing container mode.
Therefore, the present invention pass through for store containing receive furan draw coffee patch packing container, and improve in patch receive furan draw
The ageing stability of coffee provides a kind of patch product as a result, be with containing receive furan draw coffee patch and packaging bag patch
Product, the furan of receiving in patch draw the ageing stability of coffee excellent.
The present inventor conducts in-depth research to solve the above-mentioned problems, has studied and draws the patch of coffee containing receiving furan
The structure of the excellent packaging bag of ageing stability.Also, as a result, the inventors discovered that, by keeping the oxygen in packaging bag dense
Degree and/or the construction of moisture content reduction, can solve the above problem, so as to complete the present invention.
That is, the present invention relates to a kind of patch product, be there is packaging bag and be accommodated in inside the packaging bag containing receiving
Furan draws the patch product of the patch of coffee, and having makes the oxygen concentration in packaging bag and/or the construction of moisture content reduction.
According to the present invention, it is further provided the patch product of following implementation.
[1] patch product, wherein as the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag, institute
Packaging bag is stated to be made of at least two layers or more of layered product, the layered product include selected from the layer formed by hygroscopicity resin and
One or more of group composed by layer containing oxygen-absorber.
[2] patch product, wherein, will as the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag
Pouch containing hygroscopic agent and/or oxygen absorbent is encapsulated in together in the packaging bag.
[3] patch product, wherein as the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag, institute
It states and has carried out nitrogen displacement in packaging bag.
[4] patch product, wherein the packaging bag by be respectively at least two layers or more of layered product and layered product it
Between configure hot melt layer and formed, wherein the layered product includes selected from the layer formed by hygroscopicity resin and containing aerobic absorption
One or more of group composed by the layer of agent.
[5] patch product, wherein the patch is by supporter, containing at least one face of the supporter is arranged in
Have and receives furan and draw the adhesive phase of coffee and this is set contains and receive furan and draw stripping film on the adhesive phase of coffee and the patch that is formed
Agent.
[6] patch product, wherein described adhesive layer contains rubber adhesive and rosin resin.
[7] patch product, wherein described adhesive layer contain receive furan draw coffee salt and desalter.
In addition, the present invention relates to containing receive furan draw coffee patch packaging bag, the packaging bag is by least two layers or more of lamination
Body is constituted, and the layered product includes in group composed by layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber
More than one.
The effect of invention
By the present invention in that storage containing receive furan draw coffee patch packaging bag in oxygen concentration and/or moisture content reduce
Construction, achieve following effect：Be able to suppress receive furan draw coffee decomposition, so that medicament contg be inhibited to reduce at any time.Cause
This achieves following effect according to the present invention：A kind of patch that furan draws the ageing stability of coffee excellent of receiving in patch can be provided
Agent product.
Packaging bag of the invention achieves the effect for being able to suppress the decomposition of chemically unstable compound.Therefore, originally
The packaging bag of invention is suitable for being used to saving chemically unstable compound or the medicament containing the compound (such as containing receiving
Furan drawing coffee patch) packaging bag.
Detailed description of the invention
Fig. 1 be indicate include the cross-sectional view of the layered product of the layer formed by hygroscopicity resin figure.
Fig. 2 is the figure for indicating the cross-sectional view of the layered product comprising the layer containing oxygen-absorber.
(i) in Fig. 3 is partially the figure for indicating an embodiment of patch product, which has a packaging bag, and
Have inside the packaging bag and draws the patch of coffee and pouch containing hygroscopic agent containing receiving furan.
(ii) in Fig. 3 is partially the figure for indicating to constitute the cross-sectional view of layered product of the packaging bag.
(i) in Fig. 4 is partially the figure for indicating the another embodiment of patch product, which has packaging bag, and
There is patch and the pouch containing oxygen-absorber inside the packaging bag.
(ii) in Fig. 4 is partially the figure for indicating to constitute the cross-sectional view of layered product of the packaging bag.
Specific embodiment
< patch product >
The present invention relates to a kind of patch product, with packaging bag and it is accommodated in inside the packaging bag and draws the patch of coffee containing receiving furan
Agent.
< packaging bag >
Packaging bag used in the present invention has construction or reduction moisture content for reducing the oxygen concentration in packaging bag
Construction or have both constructions, thus, it is possible to which inhibiting to receive furan draws the decomposition of coffee and its salt.
As the construction of the oxygen concentration and/or moisture content reduction that make in above-mentioned packaging bag, as long as the oxygen in packaging bag can be made dense
Degree and/or moisture content are reduced, then are not particularly limited, preferably：Use the packaging being made of at least two layers or more of layered product
The mode of bag, wherein the layered product includes composed by the layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber
One or more of group；Mode pouch containing hygroscopic agent and/or oxygen absorbent being encapsulated in together in packaging bag；And it is right
The mode of nitrogen displacement is carried out in packaging bag.Wherein, it is reduced from the oxygen concentration and/or moisture content further made in packaging bag
Angle consideration, more preferably：Using the mode for the packaging bag being made of at least two layers or more of layered product, the wherein layered product packet
Include one or more of group composed by the layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber；And to packet
The mode of nitrogen displacement is carried out in pack.
In addition, in the present invention, as the above-mentioned oxygen concentration made in packaging bag and/or the construction of moisture content reduction, can incite somebody to action
Multiple aforesaid ways are applied in combination.
[using the mode for the packaging bag being made of specific layered product]
As the above-mentioned oxygen concentration made in packaging bag and/or the construction of moisture content reduction, in the case where in the following way,
The furan that can thereby inhibit to receive draws the decomposition of coffee and its salt, and this method at least two layers or more of layered product that is, using being made of
Packaging bag, the layered product include in group composed by layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber
More than one.
In addition, in the present invention, as the layer for constituting packaging bag, in addition to the layer formed by hygroscopicity resin and containing aerobic absorption
Other than the layer of agent, the layer formed by polyethylene also can be used.
As long as packaging bag used in the present invention is formed by least two layers or more of layered product, and the layered product includes
One or more of group composed by layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber, then it constitutes nothing
It is particularly limited to, for example, the embodiment of following (1) and (2) can be taken.
(1) packaging bag is formed by hygroscopicity resin layer structure and the case where constitute.
Packaging bag used in the present invention, can by will include the layer formed by hygroscopicity resin, at least two layers or more
Layered product hot melt fitting and formed.
Also, as above-mentioned layered product, for example, the layered product for being each configured with following layer can be enumerated：Sealant layer, as packet
The innermost layer of pack；The film or lamella formed by hygroscopicity resin, as the layer more more outward than the sealant layer；And air
Barrier layer, the layer more outward as the film or lamella than being formed by hygroscopicity resin；And it optionally configures arbitrary
Resin film etc., as the layer (refer to Fig. 1) more more outward than the air barrier.
The innermost layer of packaging bag is preferably heat sealable layer, i.e. sealant layer.
The sealant layer can be formed by the encapsulant resins film being currently known, wherein preferably other than being easy to heat-sealing,
The film of the ability also with higher for not adsorbing drug.
As sealant layer, for example, can enumerate：Low density polyethylene (LDPE) (LDPE), straight-chain low density polyethylene (LDPE) (L-LDPE) and
The polyethylene resin films such as high density polyethylene (HDPE) (HDPE)；Sour modified poly ethylene, polypropylene, sour modified polypropene, copolymer polypropylene,
Vinyl-vinyl acetate copolymer (EVA), ethylene-(methyl) acrylate copolymer, ethylene-(methyl) acrylic copolymer
Equal polyolefin resins film；Polyester resins films such as polyethylene terephthalate (PET) etc., if considering heat sealability, especially
Preferably non-stretched acrylic resin (hereinafter, being denoted as PP sometimes) film or non-stretched polyvinyl resin are (hereinafter, sometimes
It is denoted as PE) film.
In addition, in the present specification, (methyl) acrylic acid indicates both acrylic acid and methacrylic acid.
Sealant layer has and can be sealed and be made the minimum thickness of airtight package bag, and preferably 10 μm~50 μm, example
For example 30 μm.
The film or lamella formed by hygroscopicity resin is by dispersing hygroscopic agent or showing moisture absorption included in resin
The resin of property is formed by film or lamella.
Hygroscopic agent is not particularly limited, and barium monoxide, calcium chloride, magnesium sulfate, calcium oxide, calcium sulfate, lithium chloride, perchloric acid can be used
Lithium, aluminium oxide, silica gel, zeolite etc., may be selected more than one.
In addition, resin is not particularly limited, preferably polyolefin, especially low density polyethylene (LDPE) (LDPE), because hygroscopic agent exists
Dispersibility therein is excellent.
As the mode of the film or piece that are formed by hygroscopicity resin, MoistCatch (モ イ ス ト キ ャ ッ チ can be enumerated<Registrar
Mark>, common to print (strain) manufacture).
It is received from the viewpoint of furan draws coffee and its salt from the moisture influence prevented in air, configuration is formed by hygroscopicity resin
Film or the layer in outside of lamella be preferably air barrier.
As long as air barrier can obstruct the mixed material of the air outside packaging bag, for example, in addition to aluminium foil
It, can also be using aluminium-vapour deposition, silica steam plating, oxidation aluminium-vapour deposition, two other than soft metals foils such as (hereinafter, also referred to as AL)
The vapor deposition layer of silica-alumina binary vapor deposition etc..
(2) packaging bag is by the layer structure containing oxygen-absorber come the case where composition.
Packaging bag used in the present invention can be by that will include the layer containing oxygen-absorber, at least two layers or more of lamination
Body heat melts fitting and is formed.
Also, as above-mentioned layered product, for example, the layered product being each configured with such as lower layer can be enumerated：Sealant layer, as packaging
The innermost layer of bag；Film or lamella containing oxygen-absorber, as the layer more more outward than the sealant layer；And air barrier
Layer, as than film or the more outward layer of lamella containing oxygen-absorber；And the optionally arbitrary resin film etc. that configures,
As the layer (referring to fig. 2) more more outward than the air barrier.
The innermost layer of packaging bag is preferably heat sealable layer, i.e. sealant layer.The sealant layer can use aforementioned
(1) sealant layer shown in.
It as oxygen absorbent, is not particularly limited, other than inorganic oxide, can also enumerate：It is made of electrolyte
Mixture, reducing inorganic salt, Polyphenols, reproducibility carbohydrate, reducing agent, unsaturated fat acid compound, unsaturated organic
Close the mixture of object, thermoplastic polymer, the composition comprising oxygen absorption enhancement substance or these substances.
As the packaging material containing oxygen-absorber, for example, the mode as film or piece, can enumerate Oxyguard (オ キ シ ガ
ード<Registered trademark>, Japan's tank (strain) manufacture), OxyCatch (オ キ シ キ ャ ッ チ<Registered trademark>, common to print
(strain) manufacture), AGELESS OMAC (エ ー ジ レ ス オ ー マ ッ Network, Mitsubishi gas chemical (strain) manufacture).
It receives from the point of view of furan draws coffee and its salt, is configured in the film containing oxygen-absorber from the moisture influence prevented in air
Or the layer in the outside of lamella is preferably air barrier.The air barrier, can be using air barrier shown in aforementioned (1)
Layer.
In above-mentioned packaging bag, as packaging bag used in the present invention, receives furan from further suppressing and draw coffee and its salt
Decomposition from the perspective of, particularly preferably by be respectively at least configured between two layers or more of layered product and layered product
Hot melt layer and the packaging bag formed, wherein the layered product includes the layer formed by hygroscopicity resin and/or containing oxygen-absorber
Layer.
Hot melt layer be by by heat fusing carry out thermal welding hot-melt resin be made, by between layered product and layered product into
The layer of row thermal welding, wherein each layered product respectively includes the layer formed by hygroscopicity resin and/or the layer containing oxygen-absorber
's.
As hot-melt resin, as long as heat-fusible resin, is not particularly limited, for example, can enumerate：Polyethylene, poly- third
Alkene, vinyl-vinyl acetate copolymer, ethylene-methacrylic acid copolymer, ethylene-methyl acrylate copolymer, ethylene-
Acrylic copolymer and vinyl-acrylate copolymer etc..
Packaging bag used in the present invention is the packaging bag formed by least two layers or more of layered product, the layered product packet
More than one for the group that the layer selected from the layer formed by hygroscopicity resin and containing oxygen-absorber forms are included, the layered product is for example
There can be above-mentioned laminar structure, also can according to need and there is the laminar structure including arbitrary resin film etc..
As above-mentioned any resin film etc., for example, as the layer structure that can be used as packaging bag, leakproofness and the high tree of light-proofness
Adipose membrane can be enumerated：The polyolefin resins films such as polyethylene film, polypropylene screen, polymethylpentene film；Polychloroethylene film gathers inclined two
The vinyl resins film such as vinyl chloride film, polyvinyl alcohol film, polystyrene film, polyacrylonitrile film, ionic polymer membranes；Gather to benzene two
The polyester resins films such as formic acid second diester film；The polyamide-based resins film such as nylon membrane；The cellulosic resin films such as cellophane；Poly- carbon
Acid ester resin film；And laminated film of the above etc..In addition, as above-mentioned arbitrary resin film etc., in addition to considering leakproofness,
As the resin film for also improving light-proofness, can enumerate：Above-mentioned resin film and its laminated film etc. with soft aluminium foil (hereinafter,
Sometimes referred to simply as AL) laminated film, and the pigment addition resin film for being added in above-mentioned resin film black pigment etc. etc..?
In above-mentioned any resin film etc., these resin films, laminated film etc. can carry out various combinations and be used as layered product.
In addition, the structure as packaging bag, can be by comprising ethylene-vinyl alcohol copolymer (hereinafter, also referred to as EVOH) or
The layered product of cyclic polyolefin film (hereinafter, also referred to as COC) is formed.
One example of the specific laminar structure as the preferred layered product for packaging bag used in the present invention, from
From the perspective of the furan that makes to receive draws coffee and its salt more stable, it can enumerate with flowering structure：It is poly- second since the innermost layer of packaging bag
The layer that alkene (PE)-is formed by hygroscopicity resin or layer-AL-polyester containing oxygen absorbent etc..
Above-mentioned layered product can be manufactured by dry lamination, extrusion lamination or co-extrusion laminating, and the thickness of layered product can be set as
10 μm~100 μm or so.Each layer of contact laminating is laminated via binder etc..With binder by the feelings of interlaminar bonding
Under condition, it is preferred to use the less binder of Drug absorbability.For example, can be by toluene di-isocyanate(TDI) (TDI) or diphenyl methane
The isocyanates such as diisocyanate (MDI) are used as binder, or the polyurethane binder for being mixed with polyalcohol etc. can be used.
Package body be formed as than containing receive furan draw coffee patch it is big one circle size.The area of patch can be suitably determined, if but examining
Consider reduction medicament as far as possible to volatilize in packaging material and be attached to the amount on supporter, and considers to attach difficulty, then it is excellent
It is selected as 1cm2~25cm2。
In addition, using the plastic layer press mold comprising aluminium in the layered product for constituting packaging bag used in the present invention
In the case where material, since the tearing strength that plastic layer press mold has is high, it is difficult to be sealed off with hand, therefore multiple V are preferably arranged
Shape notch or I shape notch.
[pouch is encapsulated in the method in packaging bag together]
As the above-mentioned oxygen concentration made in packaging bag and/or the construction of moisture content reduction, the small of hygroscopic agent will be contained using
In the case where bag, the pouch containing oxygen-absorber or the method that is encapsulated in packaging bag together containing the pouch of the rwo, pass through
It is encapsulated in pouch in packaging bag, containing hygroscopic agent and/or oxygen absorbent, the furan that can inhibit to receive draws the decomposition of coffee and its salt.
In the present invention, as the side being encapsulated in the pouch containing hygroscopic agent and/or oxygen absorbent together in packaging bag
Formula, for example, the embodiment of following (3) and (4) can be taken.
(3) patch product 1 have packaging bag 2, and inside the packaging bag have containing receive furan draw coffee patch (hereafter
In, be only known as patch) 3 and the case where pouch 4 containing hygroscopic agent (referring to Fig. 3 (i).In addition, omitting packaging in Fig. 3
Atmosphere inside bag)
As above-mentioned packaging bag, for example, the layered product being each configured with such as lower layer can be enumerated：Sealant layer, as packaging bag
Innermost layer；Air barrier, as the layer more more outward than the sealant layer；And optionally and configure arbitrary resin film
Deng as the layer more more outward than the air barrier (referring to Fig. 3 (ii)).
The innermost layer of packaging bag is preferably heat sealable layer, i.e. sealant layer.The sealant layer can use aforementioned
(1) sealant layer shown in.
From the viewpoint of preventing moisture in air from influencing to receive furan draws coffee and its salt, the layer in the outside of sealant layer is configured
Preferably air barrier.The air barrier, can be using air barrier shown in aforementioned (1).
In addition, above-mentioned arbitrary resin film etc. can be used for arbitrary resin film etc..
In addition, as the above-mentioned pouch containing hygroscopic agent, as long as the mode of the moisture inside packaging bag can be absorbed in hygroscopic agent,
Then it is not particularly limited, for example, it is preferable to it is bag-shaped for hygroscopic agent cladding cited in above-mentioned (1) is made with non-woven fabrics etc.,
Or hygroscopic agent is included in non-woven fabrics etc. and sheet is made.
(4) patch product 10 has packaging bag 2, and with patch 3 inside the packaging bag and containing the small of oxygen-absorber
The case where bag 5, is (referring to fig. 4 (i).In addition, omitting the atmosphere inside packaging bag in Fig. 4)
As above-mentioned packaging bag, for example, the layered product being each configured with such as lower layer can be enumerated：Sealant layer, as packaging bag
Innermost layer；Air barrier, as the layer more more outward than the sealant layer；And optionally and configure arbitrary resin film
Deng as the layer (referring to fig. 4 (ii)) more more outward than the air barrier.
The innermost layer of packaging bag is preferably heat sealable layer, i.e. sealant layer.The sealant layer can use aforementioned
(1) sealant layer shown in.
It is received from the point of view of furan draws coffee and its salt from the moisture influence prevented in air, the layer configured in the outside of sealant layer is excellent
It is selected as air barrier.The air barrier, can be using air barrier shown in aforementioned (1).
In addition, above-mentioned arbitrary resin film etc. can be used for arbitrary resin film etc..
In addition, as the above-mentioned pouch containing oxygen-absorber, as long as oxygen absorbent can reduce the oxygen concentration in packaging bag
Mode is then not particularly limited, for example, it is preferable to make to be coated oxygen absorbent cited in above-mentioned (2) with non-woven fabrics etc.
Pouch.
[to the method for carrying out nitrogen displacement in packaging bag]
As the above-mentioned oxygen concentration made in packaging bag and/or the construction of moisture content reduction, using to carrying out nitrogen in packaging bag
In the case where the method for gas displacement, by leading the oxygen that, full of nitrogen, can inhibit in packaging bag by air and moisture
The furan of receiving caused draws the decomposition of coffee and its salt.
As to the method for carrying out nitrogen displacement in packaging bag, well known method can be used, for example, can enumerate makes to pack
Become the method etc. that vacuum injects nitrogen later in bag.
The manufacturing method > of < patch product
It as the manufacturing method of patch product of the invention, is not particularly limited, for example, the present invention can be obtained according to following manner
Patch product：At least two layers or more of the layered product of packaging bag used in the present invention will be used for (including selected from by hygroscopicity
Group composed by the layer and layer containing oxygen-absorber that resin is formed more than one), according to the frame for being greater than patch size, lead to
Cross hot melt by three sides be bonded and be made it is bag-shaped, enclose patch after, remaining heated on one side is sealed.
In addition, the manufacturing method as patch product of the invention, can obtain patch product of the invention according to following manner：It will
According to the frame for being greater than patch size bag is made by hot melt in the fitting of three sides by preferred multiple layered products for packaging bag
Shape is enclosed after patch and pouch containing hygroscopic agent and/or oxygen absorbent, remaining heated on one side is sealed.
In addition, from making to receive from the point of view of furan draws coffee more stable, moisture content or oxygen content preferably in packaging bag compared with
It is low, moisture concentration or oxygen concentration in packaging bag can be made to reduce by known method.
For example, can be by carrying out nitrogen displacement to the atmosphere in packaging bag using vacuum gas packing machine etc. and being full of nitrogen
Gas, and reduce the moisture content in packaging bag and residual oxygen concentrations.Atmosphere state in the process can use setting and carry out
Measuring device in the process of nitrogen displacement and measure moisture content and oxygen content, or using can directly enclose in packaging bag
Measuring device and measure.Using the measuring device that can directly enclose in packaging bag, it can survey at any time
Measure the moisture content and oxygen concentration in the packaging bag of patch product.
Preferred moisture content (concentration) in packaging bag in patch product is the moisture for being equivalent to relative humidity 25% at 25 DEG C
Content is hereinafter, residual oxygen concentrations are 10vol% or less.
It is measured in addition, the moisture content of patch can use infrared moisture meter, when initial value is set as 100%, 60
Change rate (moisture slip) at DEG C after thermostatic chamber saves one month is preferably 20~70%, particularly preferably 25~
50%.
In addition, above-mentioned packaging bag, that is, by least two layers or more of layered product (including selected from being formed by hygroscopicity resin
Layer and the layer containing oxygen-absorber composed by group one or more of) constitute, containing receive furan draw coffee patch packet
Pack is also object of the invention.
< contain receive furan draw coffee patch >
It hereinafter, will be to drawing the patch of coffee (hereinafter, to be also referred to simply as pasting containing receiving furan in patch product of the invention
Agent) it is described in detail.Patch be include supporter, be arranged at least one face of the supporter containing receive furan draw coffee
Adhesive phase and be arranged in this contain receive furan draw coffee adhesive phase on stripping film structure.
[supporter]
As the supporter for the patch in patch product of the invention, can enumerate：Film, non-woven fabrics, Japan paper, cotton, needle
Woven fabric, woven fabric, non-woven fabrics and Laminated composites of film etc. have the supporter of flexibility.
These supporters are preferably the soft material for the movement that can be close to skin and can follow skin, and can inhibit
The material of fash of skin etc. occurs after attaching for a long time.As the material of these supporters, for example, can enumerate：Polyethylene,
Polypropylene, polyethylene terephthalate etc..
It as the size of the supporter, is not particularly limited, can suitably be selected according to purpose.
[adhesive phase]
In the patch in patch product of the invention, the adhesive for constituting adhesive phase is not particularly limited, and can be enumerated：Rubber
Class adhesive, acrylic adhesives, silicone based adhesive, polyurethane binding, hydrocolloid class adhesive etc., particularly preferably
For rubber adhesive.
It as the construction of described adhesive layer, can be monolayer constructions, be also possible to multi-ply construction.It is more in described adhesive layer
Layer construction in the case where, as long as receive furan draw coffee be included in one layer or more.
As particularly preferred mode, described adhesive layer contains (a) elastomer, (b) selected from terpene resin and rosin resin
Both one or more of tackifier, furan of (c) receiving draws at least any one and d) desalter in coffee and its salt, according to
It needs also to contain other compositions.
The adhesive phase in patch in patch product of the invention is made of non-aqueous system, is not carried out deliberately in manufacturing process
The addition of water.
(a) elastomer
It as the elastomer, is not particularly limited, can suitably be selected according to purpose.For example, can enumerate as styrene-
SIS5002 (JSR Corp.'s manufacture) and Quintac 3520 (the auspicious father-in-law of Japan of isoprene-styrene block copolymer
Co., Ltd.'s manufacture) etc..
The elastomer can be used alone, and two or more can also be used in combination.
As the content of the elastomer in described adhesive layer, can be selected according to purpose and suitably, preferably
15wt% or more, more preferably 20wt% or more, further preferably 30wt% or more.Furthermore it is preferred that being 60wt% hereinafter, more
Preferably 50wt% is hereinafter, further preferably 40wt% or less.
(b) tackifier
As the tackifier, as long as the tackifier for improving viscosity, then be not particularly limited, preferably containing selected from terpenes
The tackifier of one or more of both resin and rosin resin.
As the terpene resin, such as can enumerate：It is nopinene resin, α pinene resin, terpene-phenol resin, aromatic modified
Terpene resin, hydrogenated terpene resin etc..
As the rosin resin, for example, can enumerate：The rosin such as gum rosin, toll oil rosin, wood rosin；Hydrogenated rosin, disproportionation
The modified rosins such as rosin, newtrex, maleic rosin；The rosin esters such as rosin glycerides, hydrogenated wood rosin glycerol ester, hydrogenated rosin glyceride
Deng.
As the tackifier, for example, can enumerate：YS RESINPX1150N (manufacture of Yasuhara Chemical Co., Ltd.)
And PINECRYSTAL KE-311 (Arakawa Chemical Industries, Ltd.'s manufacture) etc..
The tackifier can be used alone, and two or more can also be used in combination.In addition it is also possible to which the terpenes tree will be selected from
The tackifier of rouge and the rosin resin are combined.Particularly, with regard to receive furan draw the stability of coffee in terms of for, preferably rosin
Resin.
It as the content of the tackifier in described adhesive layer, is not particularly limited, can suitably be selected according to purpose
It selects, preferably 10wt% or more, more preferably 15wt% or more.Furthermore it is preferred that be 50wt% hereinafter, more preferably 40wt% with
Under, further preferably 30wt% or less.
(c) furan of receiving draws any at least within of coffee and its salt
For it is described receive furan draw coffee, also can be used free form receive furan draw coffee, but preferably as receive furan drawing coffee salt and
Mixing is within the adhesive layer.The furan of receiving draws the salt of coffee to be converted into free form by aftermentioned desalter.
The salt of coffee is drawn as furan is received, as long as pharmaceutically acceptable salt, then be not particularly limited, but with regard in terms of percutaneous permeability
For, furan of preferably receiving draws the acid-addition salts of coffee.As acid-addition salts, can enumerate：Hydrochloride, acetate, maleate, oxalic acid
Salt etc..Wherein, for percutaneous permeability, furan of preferably receiving draws coffee hydrochloride.
The furan of receiving draws the salt of coffee can be used alone, and two or more can also be used in combination.
As receive described in described adhesive layer furan draw coffee salt content, preferably 0.1wt% or more, more preferably
0.2wt% or more.In addition, preferably 5.0wt% is hereinafter, more preferably for the aspect of percutaneous permeability and skin irritation
For 4.0wt% hereinafter, further preferably 3.0wt% or less.
Furan of receiving described in the replacement draw the salt of coffee and using free form receive furan draw coffee in the case where, can will be drawn with the furan of receiving
The identical amount mixing of the content of the salt of coffee is within the adhesive layer.
In the present invention, in the case where being recorded as receiving furan drawing coffee, in case of no particular description, refer to free form
Furan of receiving draws both coffee and its pharmaceutically acceptable salt.
(d) desalter
As the desalter, as long as by receive furan draw coffee salt be converted into free form receive furan draw coffee desalter, then do not have
There is special limitation, can be selected according to purpose and suitably, such as preferably monoethanolamine, sodium bicarbonate and the height with amino
At least any one in molecular compound.
It as the content of the desalter, can be selected according to purpose and suitably, with regard to the side of skin irritation and percutaneous permeability
For face, relative to received described in 1 mole furan draw coffee salt, the content of desalter is preferably 5 moles or more, more preferable 10 moles with
On.Furthermore it is preferred that for 30 moles hereinafter, more preferably 25 moles or less.
As the preparation method of the desalter, it can once be carried out in manufacturing process, can also divide and carry out several times.
In the case where the desalter is monoethanolamine or sodium bicarbonate, in described adhesive layer, preferably
0.01wt% or more, more preferably 0.1wt% or more, further preferably 0.3wt% or more.Furthermore it is preferred that for 10wt% with
Under, more preferably 5.0wt% is hereinafter, further preferably 1.0wt% or less.
As the high-molecular compound with amino, in terms of percutaneous permeability, preferably by (methyl) third
Olefin(e) acid dialkyl group (methyl or ethyl) aminoalkyl (methyl or ethyl) ester, be selected from (methyl) acrylic acid alkyl (methyl, second
Base, propyl or butyl) ester, (methyl) acrylic acid monohydroxy alkyl (ethyl, propyl or butyl) ester and these above-mentioned combination
Copolymer composed by monomeric unit.
As this high-molecular compound with amino, for example, can enumerate as methyl methacrylate-methacrylic acid fourth
Ester-dimethylaminoethyl methacrylate copolymer EUDRAGIT (オ イ De ラ ギ ッ ト, registered trademark) EPO (Evonik
Company's manufacture) etc..
In the case where the desalter is the high-molecular compound with amino, in described adhesive layer, preferably
1.0wt% or more, more preferably 2.0wt% or more.In addition, for the aspect of percutaneous permeability and skin irritation,
In described adhesive layer, preferably 40wt% or less.
The desalter can be used alone, and two or more can also be used in combination.
As the average thickness of described adhesive layer, can be selected according to purpose and suitably, it is preferably 5 μm~500 μm, more excellent
It is selected as 10 μm~300 μm, further preferably 20 μm~200 μm.
In the present invention, described adhesive layer can also further contain other medicines, softening agent, antioxidant, absorption
Other additives such as promotor, inorganic filler, ultraviolet absorbing agent, antioxidant.
[stripping film]
In addition, as the stripping film for the patch in patch product of the invention, be preferably difficult to absorb/adsorb adhesive phase
In drug etc. material, for example, can enumerate：Polyester film of the one or two sides through silicone-treated, the polyethylene through silicone-treated
It is laminated fine paper, glassine paper through silicone-treated etc..
The manufacturing method > of < patch
The manufacturing method of patch in patch product of the invention is not particularly limited, and can select according to purpose and suitably, example
Such as, it can enumerate：It prepares and draws the salt of coffee and the adhesive composition of desalter containing elastomer, tackifier, furan of receiving, and applied
Method of the cloth on supporter；The method etc. of supporter is bonded after being coated on stripping film.
[medication]
It as the administration time of the patch, is not particularly limited, can be selected according to purpose and suitably, preferably be applied to skin
24 hours or more.
Embodiment
Hereinafter, showing embodiment and the present invention is specifically described in comparative example, but the present invention is not limited to these
Embodiment.In embodiment, furan of receiving draw coffee all using receive furan drawing coffee hydrochloride.
(embodiment 1)
For the styrene-isoprene-styrene block copolymer (SIS as the elastomer；Trade name " SIS5002 ",
JSR Corp.'s manufacture) 7.97wt%, styrene-isoprene-styrene block copolymer (SIS；Trade name " Quintac
3520 ", Zeon Corp's manufacture) 23.9wt%, terpene resin (trade name " the YS RESIN as the tackifier
The manufacture of PX1150N ", Yasuhara Chemical Co., Ltd.) 19.1wt%, the atoleine (commodity as the softening agent
Name " HICALL M352 ", the manufacture of KANEDA Co., Ltd.) it 48.48wt%, as the furan of receiving draws the salt of coffee and is dissolved in appropriate
Furan of receiving in methanol draws the coffee hydrochloride 0.25wt% and monoethanolamine 0.3wt% as the desalter, with solid component
The mode for becoming 50wt% is added organic solvent (toluene), and is mixed up to uniform, so that adhesive composition be made.Then,
By adhesive composition obtained with 30 μm of average thickness, it is applied to as covering material (stripping film) through silicone-treated
Polyester film (75 μm of average thickness) on, formed adhesive phase.Layered polyester film is as supporter on the adhesive phase, and cuts out
It is cut to 7.5cm2Size and make patch 1.
It is as described below to make patch product 1 for patch 1 obtained, and ageing stability test as follows is carried out, it comments
The stability of drug in valence patch.Evaluation result is as shown in table 1.
< stability test >
For patch 1~6, using using configuring innermost layer for PAN (Polyacrylonitrile, polyacrylonitrile) and by AL
It is configured to the packaging bag of the layered product of air barrier, patch product 1~6 is made, for carrying out following tests.
For patch 7~9, using using MoistCatch, (Kyodo Printing Co., Ltd. is manufactured, sealant layer-moisture absorption layer-
Aluminium-PET) and the packaging bag that obtains, for patch 10~12, using using OxyCatch (Kyodo Printing Co., Ltd. manufactures,
PE (sealant layer)-oxygen absorbed layer-aluminium-PET) and the packaging bag of acquisition, patch product 7~12 is made, it is following for carrying out
Test.
Specifically, patch is accommodated in each packaging bag, it is by heating that packaging bag is close after carrying out nitrogen displacement in bag
Envelope, then saves at 60 DEG C.When saving beginning and after saving beginning 3 months, by high performance liquid chromatography to patch
In receive furan draw coffee content quantified.Furan of receiving after calculating 3 months draws coffee content to draw relative to the furan of receiving saved when starting
The percentage of coffee content, and it is set to medicament residue rate (%).
(embodiment 2)
In embodiment 1, the amount of the softening agent is changed to by addition 0.05wt%BHT as antioxidant from 48.48wt%
48.43wt% makes patch 2 and patch product 2, and evaluated in addition to this in the same manner as in Example 1.
(embodiment 3)
In embodiment 1, instead of " YS RESIN PX1150N " 19.1wt% as terpene resin, and using as rosin resin
" PINECRYSTAL KE-311 (super light-colored rosin esters) " (manufacture of Arakawa Chemical Industries company) 19.1wt% as described
Tackifier make patch 3 and patch product 3, and evaluated in addition to this in the same manner as in Example 1.
(embodiment 4)
In embodiment 3, instead of monoethanolamine 0.3wt%, and using the " EUDRAGIT as the high-molecular compound containing amino
EPO " (manufacture of Evonik company) 3.2wt% is as desalter, and BHT 0.05wt% is as antioxidant for addition, will be described soft
The amount of agent is changed to 45.53wt% from 48.48wt%, in addition to this, with method production patch 4 same as Example 3 with
And patch product 4, and evaluated.
(embodiment 5)
In example 4, antioxidant is not added, the amount of the softening agent is changed to 45.58wt% from 45.53wt%, is removed
Other than this, with method production patch 5 same as Example 4 and patch product 5, and evaluated.
(embodiment 6)
In embodiment 5, the furan of receiving that furan draws coffee hydrochloride to become free form that will receive draws coffee, does not add desalter, will be described soft
The amount of agent is changed to 48.78wt% from 45.58wt%, in addition to this, with method production patch 6 same as Example 5 with
And patch product 6, and evaluated.
(embodiment 7)
In example 4, by packaging material be changed to include the layer formed by hygroscopicity resin MoistCatch (common printing
Co., Ltd.'s manufacture), in addition to this, with method production patch 7 same as Example 4 and patch product 7, and evaluated.
(embodiment 8)
In embodiment 5, packaging material is changed to include the layer formed by hygroscopicity resin MoistCatch (common printing
Co., Ltd.'s manufacture), in addition to this, with method production patch 8 same as Example 5 and patch product 8, and evaluated.
(embodiment 9)
In example 2, instead of " YS RESIN PX1150N " 19.1wt% as terpene resin, and using as rosin resin
" PINECRYSTAL KE-311 (super light-colored rosin esters) " (manufacture of Arakawa Chemical Industries company) 19.1wt% as described
Tackifier, packaging material is changed to include the layer formed by hygroscopicity resin MoistCatch (Kyodo Printing Co., Ltd.
Manufacture), in addition to this, with method production patch 9 same as Example 2 and patch product 9, and evaluated.
(embodiment 10)
In example 4, by packaging material be changed to include the layer containing oxygen-absorber OxyCatch (common printing strain formula meeting
Society's manufacture), in addition to this, with method production patch 10 same as Example 4 and patch product 10, and evaluated.
(embodiment 11)
In embodiment 5, packaging material is changed to include the layer containing oxygen-absorber OxyCatch (common printing strain formula meeting
Society's manufacture), in addition to this, with method production patch 11 same as Example 5 and patch product 11, and evaluated.
(embodiment 12)
In example 2, instead of " YS RESIN PX1150N " 19.1wt% as terpene resin, and using as rosin resin
" PINECRYSTAL KE-311 (super light-colored rosin esters) " (manufacture of Arakawa Chemical Industries company) 19.1wt% as described
Tackifier, packaging material is changed to include the layer containing oxygen-absorber OxyCatch (Kyodo Printing Co., Ltd.'s manufacture),
In addition to this, it with method production patch 12 same as Example 2 and patch product 12, and is evaluated.
(comparative example 1)
In example 4, being changed to innermost layer is to make aluminium packaging bag as main component with polyethylene, in addition to this, with reality
The identical method of example 4 production patch 13 and patch product 13 are applied, and is evaluated.
(moisture content of patch)
For the patch product 7 prepared in the patch product 13 and above-described embodiment 7 that are prepared in above-mentioned reference example 1, measure each
The moisture content of patch.
Specifically, patch 7 and patch 13 are accommodated in respectively in respective packaging bag, after carrying out nitrogen displacement in bag, are led to
It crosses hot melt to seal packaging bag, then be saved at 60 DEG C.When saving beginning and after saving beginning 1 month, by infrared
Moisture Meter (AD-4715, Co., Ltd. A&D production) quantifies the moisture content in patch.Moisture after calculating 1 month
Percentage of the content relative to moisture content when saving beginning in product, and it is set to moisture content change rate (%).
In addition, drying temperature is set as 100 DEG C by infrared moisture meter, monitoring time is set as 300 seconds, the variable quantity of measured value is existed
It is measured when becoming 0.05% or less in monitoring time as final measured value.
【Table 1】
As shown in Table 1, according to the construction for making oxygen concentration and/or hydrogen concentration reduction used in embodiment, then
Even if in harsh test at a high temperature of 60 DEG C, and realize patch 1~12 (embodiment 1~12) medicine stability it is good
Good patch product.Wherein, use OxyCatch as the patch product 10~12 of packaging material, even if especially protecting at 60 DEG C
It deposits 3 months, the drug residue in patch 10~12 is also 96% or more, is extraordinary result.In addition, know with patch 4,
5, it 7,8 is compared with 10-11, the structure of the adhesive phase as patch, using including styrene-isoprene-phenylethene block
The structure of copolymer (SIS), and use comprising rosin resin as tackifier, the high-molecular compound conduct comprising containing amino
The structure of desalter is more preferable.
In addition, the moisture of patch 7 is reduced when having carried out preservation in 1 month at 60 DEG C using the patch product 7 of MoistCatch
Change rate (%) is 37%, and on the other hand, it is 11% that the moisture of the patch 13 in patch product 13, which reduces change rate,.It thus can be true
Recognize, by using by the packaging bag including the layer formed by hygroscopicity resin, at least two layers or more of layered product is constituted, packaging
Moisture in material is effectively absorbed.
Description of symbols
1 patch product
2 packaging bags
3 containing receive furan draw coffee patch
4 pouches containing hygroscopic agent
5 pouches containing oxygen-absorber
10 patch products
Claims (9)
1. a kind of patch product, which is characterized in that
The patch product be there is packaging bag and be accommodated in inside the packaging bag containing receive furan draw coffee patch patch produce
Product,
The patch product have make the oxygen concentration in the packaging bag and/or the construction of moisture content reduction.
2. patch product according to claim 1, which is characterized in that
As the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag, the packaging bag by least two layers with
On layered product formed, the layered product includes the layer institute group selected from the layer that is formed by hygroscopicity resin and containing oxygen-absorber
At one or more of group.
3. patch product according to claim 1, which is characterized in that
As the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag, will be absorbed containing hygroscopic agent and/or oxygen
The pouch of agent is encapsulated in together in the packaging bag.
4. patch product according to claim 1, which is characterized in that
As the construction of the oxygen concentration and/or moisture content reduction that make in the packaging bag, nitrogen has been carried out in the packaging bag
Displacement.
5. patch product according to claim 1 or 2, which is characterized in that the packaging bag is by being respectively at least two
Layer or more layered product and layered product between configure hot melt layer and formed, wherein the layered product includes selected from by hygroscopicity tree
One or more of group composed by the layer that rouge is formed and the layer containing oxygen-absorber.
6. patch product according to any one of claim 1 to 5, which is characterized in that the patch is by supporter, sets
Set the adhesive phase of coffee is drawn and this is set containing and receive furan and draw coffee containing receiving furan at least one face of the supporter
Stripping film on adhesive phase and the patch formed.
7. patch product according to claim 6, which is characterized in that described adhesive layer contain rubber adhesive and
Rosin resin.
8. patch product according to claim 6 or 7, which is characterized in that described adhesive layer contain receive furan draw coffee salt
And desalter.
9. it is a kind of containing receive furan draw coffee patch packaging bag, which is characterized in that it is by least two layers or more of layered product structure
At one that, the layered product includes in group composed by layer selected from the layer formed as hygroscopicity resin and containing oxygen-absorber
Kind or more.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016071867 | 2016-03-31 | ||
| JP2016-071867 | 2016-03-31 | ||
| PCT/JP2017/013403 WO2017170933A1 (en) | 2016-03-31 | 2017-03-30 | Adhesive patch product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108883025A true CN108883025A (en) | 2018-11-23 |
Family
ID=59964810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780021397.4A Pending CN108883025A (en) | 2016-03-31 | 2017-03-30 | patch product |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPWO2017170933A1 (en) |
| CN (1) | CN108883025A (en) |
| TW (1) | TW201806587A (en) |
| WO (1) | WO2017170933A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019229892B2 (en) | 2018-03-08 | 2025-01-30 | University Of Kansas | Treatment of demyelinating diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005072716A1 (en) * | 2004-01-30 | 2005-08-11 | Hisamitsu Pharmaceutical Co., Inc. | Plaster enclosing packaging bag |
| EP1872784A4 (en) * | 2005-04-20 | 2012-06-20 | Senju Pharma Co | Medicinal preparation for percutaneous absorption |
| WO2010123103A1 (en) * | 2009-04-24 | 2010-10-28 | 久光製薬株式会社 | Adhesive patch-containing package bag and method for storing adhesive patch |
| JP5700414B2 (en) * | 2011-02-02 | 2015-04-15 | 東洋製罐株式会社 | Hygroscopic resin composition and hygroscopic multilayer container |
| JP6182744B2 (en) * | 2013-03-29 | 2017-08-23 | 三笠製薬株式会社 | Nalfurafine-containing transdermal absorption patch |
| JP6359014B2 (en) * | 2013-08-21 | 2018-07-18 | 久光製薬株式会社 | Patch |
| JP6306594B2 (en) * | 2013-08-21 | 2018-04-04 | 久光製薬株式会社 | Patch |
-
2017
- 2017-03-30 CN CN201780021397.4A patent/CN108883025A/en active Pending
- 2017-03-30 WO PCT/JP2017/013403 patent/WO2017170933A1/en active Application Filing
- 2017-03-30 JP JP2018509465A patent/JPWO2017170933A1/en active Pending
- 2017-03-31 TW TW106110938A patent/TW201806587A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2017170933A1 (en) | 2019-02-28 |
| WO2017170933A1 (en) | 2017-10-05 |
| TW201806587A (en) | 2018-03-01 |
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