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CN108853431A - A kind of Chinese medicine composition and preparation method thereof for treating gastric cancer - Google Patents

A kind of Chinese medicine composition and preparation method thereof for treating gastric cancer Download PDF

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CN108853431A
CN108853431A CN201810973476.1A CN201810973476A CN108853431A CN 108853431 A CN108853431 A CN 108853431A CN 201810973476 A CN201810973476 A CN 201810973476A CN 108853431 A CN108853431 A CN 108853431A
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gastric cancer
chinese medicine
medicine composition
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陈海林
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Abstract

The invention discloses a kind of Chinese medicine compositions for treating gastric cancer, specifically include following component:Fingered citron, the dried immature fruit of citron orange, santal, Radix Curcumae, tsaoko, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, cattail pollen, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, radix polygonati officinalis, lotus root, roud cardamon seed, radices trichosanthis, endothelium corneum gigeriae galli, cuttlebone, the seed of Oriental arborvitae, fructus cannabis, aspongopus, semen coicis, Radix Notoginseng, blood clam, Chinese yam, raw tortoise plastron, raw turtle shell and Radix Glycyrrhizae on stone;Have the advantages that treat gastric cancer significant effect, Small side effects.Meanwhile a kind of preparation method of Chinese medicine composition for treating gastric cancer is also disclosed, preparation process is simple, low using cost of material, production cost is low, is conducive to be promoted the use of.

Description

A kind of Chinese medicine composition and preparation method thereof for treating gastric cancer
Technical field
The present invention relates to field of medicine preparing technology, more particularly to a kind of Chinese medicine composition for treating gastric cancer and Preparation method.
Background technique
Gastric cancer (gastric carcinoma) is initiated by the malignant tumour of gastric epithelial, various pernicious swollen in China Disease incidence ranks first in tumor, and site of pathological change includes:The cancerations such as cardia, body of stomach, pylorus, exedens, with progressive epigastric pain, food Few thin, hematochezia is common treatment symptom.Most gastric cancers belong to gland cancer, early stage non-evident sympton, or occur epigastric discomfort, The nonspecific symptoms such as belch, it is often similar to the stomaches chronic disease symptom such as gastritis, gastric ulcer, it is easily ignored, therefore cause gastric cancer Disease incidence and lethality obviously increase.Currently, the therapeutic modality of gastric cancer is predominantly performed the operation, chemotherapy and radiation.
But there are apparent defects for current curing gastric cancer means:On the one hand, existing treatment means are brought to patient Side effect it is very big, therapeutic process pain, and treat cost it is relatively high;On the other hand, therapeutic effect is undesirable, cannot The problems such as effectively solving metastases, recurrence.
Therefore it provides a kind of treat gastric cancer significant effect, Small side effects and Chinese medicine composition at low cost and its preparation side The problem of method is those skilled in the art's urgent need to resolve.
Summary of the invention
In view of this, the present invention provides a kind of Chinese medicine compositions for treating gastric cancer can effectively treat gastric cancer, and produce Raw Small side effects;The invention discloses a kind of preparation method of Chinese medicine composition for treating gastric cancer, easy to operate, raw materials simultaneously Utilization rate is high.
To achieve the goals above, the present invention adopts the following technical scheme that:
A kind of Chinese medicine composition for treating gastric cancer, which is characterized in that specifically include the component of following parts by weight:15~30 parts Fingered citron, 15~30 parts of dried immature fruit of citron oranges, 15~30 portions of santals, 15~30 portions of Radix Curcumaes, 15~30 parts of tsaokos, 15~30 parts of rhizome of chuanxiongs, 10~25 Part root of three-nerved spicebush, 15~30 parts of rhizoma corydalis, 15~30 parts of cattail pollens, 10~20 parts of olibanums, 10~25 parts of myrrhs, 15~25 parts of rhizoma nardostachyos, 15~30 portions of hairyvein agrimonies, 15~30 portions of flos caryophyllis, 15~30 parts of akebiaes, 15~30 parts of Concretio Silicea Bambusaes, 15~30 parts of full Snakegourd Fruits, 15 ~30 parts of rhizoma polygonatis, 15~30 portions of radix polygonati officinalis, lotus root, 15~30 parts of roud cardamon seeds, 15~30 portions of radices trichosanthis, 15~30 parts on 15~30 parts of stones Endothelium corneum gigeriae galli, 15~30 portions of cuttlebones, 15~30 parts of seed of Oriental arborvitaes, 25~40 parts of fructus cannabis, 15~30 portions of aspongopus, 15~30 parts of heart of a lotus seeds The seed of jog's tears, 15~30 portions of Radix Notoginseng, 25~35 parts of blood clams, 15~30 portions of Chinese yams, 20~40 parts of raw tortoise plastrons, 20~40 parts of raw turtle shells and 10~20 portions of Radix Glycyrrhizaes.
Preferably, the component of following parts by weight is specifically included:
20 portions of fingered citrons, 20 parts of dried immature fruit of citron oranges, 20 portions of santals, 20 portions of Radix Curcumaes, 20 parts of tsaokos, 20 parts of rhizome of chuanxiongs, 15 parts of roots of three-nerved spicebush, 20 parts prolong Hu Suo, 20 parts of cattail pollens, 15 parts of olibanums, 15 parts of myrrhs, 20 parts of rhizoma nardostachyos, 20 portions of hairyvein agrimonies, 20 portions of flos caryophyllis, 20 parts of akebiaes, 20 parts of Concretio Silicea Bambusaes, 20 parts of full Snakegourd Fruits, 20 parts of rhizoma polygonatis, 20 portions of radix polygonati officinalis, lotus root, 20 parts of roud cardamon seeds, 20 portions of radices trichosanthis, 20 parts on 20 parts of stones Endothelium corneum gigeriae galli, 20 portions of cuttlebones, 20 parts of seed of Oriental arborvitaes, 30 parts of fructus cannabis, 20 portions of aspongopus, 20 parts of semen coicis, 20 portions of Radix Notoginseng, 30 parts watts Stupefied son, 20 portions of Chinese yams, 30 parts of raw tortoise plastrons, 30 parts of raw turtle shells and 15 portions of Radix Glycyrrhizaes.
Wherein:
Fingered citron:There are dispersing stagnated hepatoqi and helmet analgesic, eliminating dampness and eliminating phlegm effect;
The dried immature fruit of citron orange:It is bitter, cold in nature, enter spleen, stomach meridian, has effects that relieving stagnant Qi disperse accumulation, resolving sputum except ruffian;
Santal:It is acrid flavour, warm-natured, enter spleen, stomach, lung channel, has effects that promoting the circulation of qi middle benefit gas, appetizing analgesic;
Radix Curcumae:Acrid flavour is bitter, cold in nature, returns liver, the heart, lung channel, has promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, the cool blood that clears away heart-fire, normalizing gallbladder to cure jaundice The effect of;
Tsaoko:It is acrid flavour, warm-natured, nontoxic, enter the spleen channel, stomach meridian, has effects that eliminating dampness middle benefit gas, eliminating phlegm preventing malaria;
Rhizome of chuanxiong:It is acrid flavour, warm-natured, return liver, gallbladder, pericardium channel, has effects that blood-activating and qi-promoting, wind-expelling pain-stopping;
The root of three-nerved spicebush:Acrid flavour, warm-natured, return lung, spleen, kidney, bladder meridian have effects that promoting qi circulation and relieving pain, warming kidney for dispelling cold;
Rhizoma corydalis:Acrid flavour is bitter, warm-natured, returns liver, the spleen channel, has effects that promoting blood circulation, promoting the circulation of qi, analgesic;
Cattail pollen:It is acrid-sweet flavor, cool in nature, enter liver, the heart channel of Hang-Shaoyin, there is hemostasis, stagnation resolvation, treating stranguria effect;
Olibanum:Acrid flavour hardship, warm-natured, return heart, liver, the spleen channel, have effects that blood-activating and qi-promoting, inducing meastruation to relieve menalgia, detumescence and promoting granulation;
Myrrh:Acrid flavour is bitter, mild-natured, and return heart, liver, the spleen channel have effects that scattered stasis pain, detumescence and promoting granulation;
Rhizoma nardostachyos:Acrid-sweet flavor, warm-natured, returns spleen, stomach meridian, have effects that regulating qi-flowing for relieving pain, open it is strongly fragrant be amusing, clearing damp detumescence;
Hairyvein agrimony:It is sweet, mild-natured, enter lung, liver, the spleen channel, has effects that astringing to arrest bleeding, stop dysentery, desinsection;
Flos caryophylli:Acrid flavour, warm-natured, returns spleen, stomach, lung, kidney channel have effects that middle benefit gas drop is inverse, tonify the kidney and support yang;
Akebiae:It is bitter, cold in nature, return liver, the spleen channel, the effect of liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis;
Concretio Silicea Bambusae:It is sweet in flavor, cold in nature, have effects that heat phlegm, the arresting convulsion of the cool heart;
Full Snakegourd Fruit:Sweet in flavor, cold in nature, return lung, stomach, large intestine channel have effects that clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizing dryness and lubricating intestine;
Rhizoma polygonati:It is sweet in flavor, mild-natured, have effects that Yin nourishing and lung moistening, invigorate the spleen and benefit qi, Zishen fill fine;
Radix polygonati officinalis:It is sweet in flavor, mild-natured, enter lung, stomach meridian, has effects that Yin nourishing and lung moistening, reinforcing stomach reg fluid;
Lotus root on stone:Sweet in flavor, cool in nature, return lung, the spleen channel have effects that nourishing Yin and moistening lung, cool blood, hemostasis;
Roud cardamon seed:It is acrid flavour, warm-natured, enter lung, spleen, stomach meridian, has effects that regulating the flow of QI to ease the stomach, dry cold-dampness, relieving alcoholism;
Radices trichosanthis:Sweet-bitter flavor, cold nature, attach to the lung and stomach meridians, and have effects that clearing heat-fire, promote the production of body fluid to quench thirst, detumescence and apocenosis;
Endothelium corneum gigeriae galli:Sweet in flavor, cold in nature, returns spleen, stomach, small intestine, bladder meridian have stomach invigorating and digestion promoting effects, arresting seminal emission, treating stranguria fossil Effect
Cuttlebone:Taste is salty and bitter, warm-natured, returns spleen, kidney channel, has astringing to arrest bleeding, relieving leukorrhea by astringents, hyperacidity and pain relief, hygroscopic sore The effect of;
The seed of Oriental arborvitae:Sweet in flavor, mild-natured, return heart, kidney, large intestine channel have effects that mental-tranquilization, relax bowel and defecation, hidroschesis;
Fructus cannabis:Sweet in flavor, mild-natured, returns spleen, stomach, large intestine channel have effects that relax bowel and defecation;
Aspongopus:Taste is salty, warm-natured, and liver,spleen,kidney is returned to pass through, and has regulating qi-flowing for relieving pain, effect that middle benefit gas is supporing yang;
Semen coicis:Slightly sweet flavor, cool in nature, returns spleen, stomach, lung channel, wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, solution with sharp water penetration The effect of malicious dissipating bind;
Radix Notoginseng:Sweet in flavor, slight bitter, it is warm-natured, return liver, stomach meridian, has effects that promoting blood circulation and hemostasis, stagnation resolvation analgesic therapy;
Blood clam:Taste is salty, mild-natured, and return lung, stomach, Liver Channel have effects that removing phlegm and blood stasis, resolving hard lump, hyperacidity and pain relief.
Chinese yam:It is sweet in flavor, warm-natured, enter lung channel, the spleen channel, kidney channel, has effects that invigorating the spleen, tonifying lung, reinforces the kidney, strengthening the essence;
Raw tortoise plastron:The salty sweet, cold nature of taste, returns liver, kidney, the heart channel of Hang-Shaoyin, has the function of nourishing and suppressing Yang, the strong bone of kidney-nourishing, blood-nourishing bushing Effect;
Raw turtle shell:Taste is salty, cold nature, and return liver warp, kidney channel have effects that nourishing yin and clearing heat, calming the liver to stop the wind, resolving hard lump;
Radix Glycyrrhizae:It is sweet, mild-natured, return stomach, lung, the spleen channel, has effects that clearing heat and detoxicating, expelling phlegm and arresting coughing, stomach duct and abdomen;
Gastric cancer can quickly and effectively be treated by the mutual cooperation between bulk pharmaceutical chemicals, and effectively solve metastases, The problems such as recurrence, the Small side effects of generation, using effect are significant.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, which is characterized in that specifically includes Following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein is taken to carry out frying respectively;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter water immersion;
(4) it takes raw tortoise plastron therein and raw turtle shell to add water, then decocts and obtain medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate;
(6) medical fluid that step (5) obtains first is heated to boiling, then proceedes to heat under agitation;Finally incite somebody to action To medical fluid by filtering, medicament and the dregs of a decoction are respectively obtained;
(7) water is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively obtains medicament and medicine Slag;
(8) Radix Notoginseng is crushed, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained described control Treat the Chinese medicine composition of gastric cancer.
The beneficial effect of above-mentioned optimal technical scheme is:Reasonable processing means are selected according to the characteristic of bulk pharmaceutical chemicals, thus The drug effect of each bulk pharmaceutical chemicals can be made to give full play to, improve raw material availability, and can guarantee that whole Chinese medicine composition has treatment The effect of gastric cancer;Meanwhile the whole preparation process of use is easy to operate, easy to accomplish, has real value.
Preferably, the water that 0~15 DEG C of 8~10 mass multiple is added in the step (3) impregnates 60~120min.
The beneficial effect of above-mentioned optimal technical scheme is:Suitable water is first added and impregnates bulk pharmaceutical chemicals, can make therein to have Effect ingredient can be extracted adequately, and the performance of drug effect is promoted.
Preferably, the water of 6~8 mass multiples is added in the step (4), is then decocted under 90~120 DEG C of heating conditions Boil 15~30min.
Preferably, continue 40~80min of immersion in the step (5).
Preferably, continue to heat 45-50min under the conditions of 75~90 DEG C after boiling in the step (6).
Preferably, the water of 6~8 mass multiples is added in the step (7).
Preferably, Radix Notoginseng is crushed to 200 mesh~120 mesh in the step (8).
The beneficial effect of above-mentioned optimal technical scheme is:Radix Notoginseng powder is crushed to 200 mesh~120 mesh, facilitates absorption of human body, Be conducive to drug effect performance.
It can be seen via above technical scheme that compared with prior art, a kind of Chinese medicine composition for treating gastric cancer, with gastric cancer Medicament composing prescription is carried out for the interpretation of the cause, onset and process of an illness, determines the time pharmacology and medicine generation that pharmacological property plays in the conversion of this pathomechanism, evolution process Power promotes the intracorporal transformation of cancer cell, reduces and wither away, develops through multi-faceted gasification, cancer cell is reversed rapidly as people Body normal physiological cell has the advantages that treat gastric cancer significant effect, Small side effects to achieve the effect that treat gastric cancer.Together When, also disclose a kind of preparation method of Chinese medicine composition for treating gastric cancer, preparation process is simple, it is low using cost of material, Production cost is low, is conducive to be promoted the use of.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis The attached drawing of offer obtains other attached drawings.
Fig. 1 attached drawing is 1 diagnostic result of case provided by the invention report;
Fig. 2 attached drawing is examining report after case 1 provided by the invention is cured;
Fig. 3 attached drawing is 2 diagnostic result of case provided by the invention report.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a kind of Chinese medicine compositions for treating gastric cancer, which is characterized in that specifically includes following weight Measure the component of part:15~30 portions of fingered citrons, 15~30 parts of dried immature fruit of citron oranges, 15~30 portions of santals, 15~30 portions of Radix Curcumaes, 15~30 parts of tsaokos, 15~30 parts of rhizome of chuanxiongs, 10~25 parts of roots of three-nerved spicebush, 15~30 parts of rhizoma corydalis, 15~30 parts of cattail pollens, 10~20 parts of olibanums, 10~25 parts of systems Myrrh, 15~25 parts of rhizoma nardostachyos, 15~30 portions of hairyvein agrimonies, 15~30 portions of flos caryophyllis, 15~30 parts of akebiaes, 15~30 portions of nandinas Lotus root, 15~30 parts of roud cardamon seeds, 15 on Huang, 15~30 parts of full Snakegourd Fruits, 15~30 parts of rhizoma polygonatis, 15~30 portions of radix polygonati officinalis, 15~30 parts of stones ~30 portions of radices trichosanthis, 15~30 parts of endothelium corneum gigeriae gallis, 15~30 portions of cuttlebones, 15~30 parts of seed of Oriental arborvitaes, 25~40 parts of fructus cannabis, 15~ 30 portions of aspongopus, 15~30 parts of semen coicis, 15~30 portions of Radix Notoginseng, 25~35 parts of blood clams, 15~30 portions of Chinese yams, 20~40 parts of lifes Tortoiseshell, 20~40 parts of raw turtle shells and 10~20 portions of Radix Glycyrrhizaes.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, specifically comprise the following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein frying under the conditions of 75~90 DEG C respectively are taken 20~40min;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter 60~120min of water immersion under the conditions of 0~15 DEG C of 8~10 mass multiple;
(4) it takes raw tortoise plastron therein and raw turtle shell to add the water of 6~8 mass multiples, decocts 15 under 90~120 DEG C of heating conditions ~30min, obtains medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues 40~80min of immersion;
(6) then the medical fluid heat for obtaining step (5) continues to heat 45-50min simultaneously under the conditions of 75~90 DEG C to boiling It is stirred continuously;Then medical fluid will be obtained by filtering, respectively obtain medicament and the dregs of a decoction;
(7) water of 6~8 mass multiples, the then repeatedly operation of step (6), difference are added in the dregs of a decoction that step (6) obtains Obtain medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed to 200 mesh~120 mesh, the medicament then obtained with step (6) and step (7) uniformly mixes The Chinese medicine composition of the treatment gastric cancer can be obtained.
Embodiment 1
The embodiment of the present invention 1 discloses a kind of Chinese medicine composition for treating gastric cancer, specifically includes the component of following weight: 150g fingered citron, the 150g dried immature fruit of citron orange, 150g santal, 150g Radix Curcumae, 150g tsaoko, 150g rhizome of chuanxiong, the 100g root of three-nerved spicebush, 150g rhizoma corydalis, 150g cattail pollen, 100g olibanum, 100g myrrh, 150g rhizoma nardostachyos, 150g hairyvein agrimony, 150g flos caryophylli, 150g akebiae, 150g days The full Snakegourd Fruit of tabasheer, 300g, 300g rhizoma polygonati, 300g radix polygonati officinalis, lotus root on 300g stone, 300g roud cardamon seed, 300g radices trichosanthis, in 300g chicken Gold, 300g cuttlebone, the 300g seed of Oriental arborvitae, 400g fructus cannabis, 300g aspongopus, 300g semen coicis, 300g Radix Notoginseng, 350g corrugation The raw turtle shell of son, 300g Chinese yam, 400g raw tortoise plastron, 400g and 200g Radix Glycyrrhizae.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, specifically comprise the following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein frying under the conditions of 75 DEG C respectively are taken 40min;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter the water immersion 120min under the conditions of 15 DEG C of 8 mass multiple;
(4) it takes raw tortoise plastron therein and raw turtle shell to add the water of 6 mass multiples, decocts 30min under 90 DEG C of heating conditions, obtain Medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate 40min;
(6) then the medical fluid heat for obtaining step (5) continues to heat 50min under the conditions of 75 DEG C and constantly stir to boiling It mixes;Then medical fluid will be obtained by filtering, respectively obtain medicament and the dregs of a decoction;
(7) water of 6 mass multiples is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively To medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed to 200 mesh, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained The Chinese medicine composition of the treatment gastric cancer.
Embodiment 2
The embodiment of the present invention 2 discloses a kind of Chinese medicine composition for treating gastric cancer, which is characterized in that specifically includes following weight Measure the component of part:300g fingered citron, the 300g dried immature fruit of citron orange, 300g santal, 300g Radix Curcumae, 300g tsaoko, 300g rhizome of chuanxiong, the 250g root of three-nerved spicebush, 300g rhizoma corydalis, 300g cattail pollen, 200g olibanum, 250g myrrh, 250g rhizoma nardostachyos, 300g hairyvein agrimony, 300g flos caryophylli, 300g eight Month bundle, 300g Concretio Silicea Bambusae, the full Snakegourd Fruit of 150g, 150g rhizoma polygonati, 150g portions of radix polygonati officinalis, lotus root, 150g roud cardamon seed, 150g smallpox on 150g stone Powder, 150g endothelium corneum gigeriae galli, 150g cuttlebone, the 150g seed of Oriental arborvitae, 250g fructus cannabis, 150g aspongopus, 150g semen coicis, 150g tri- Seven, the raw turtle shell of 250g blood clam, 150g Chinese yam, 200g raw tortoise plastron, 200g and 100g Radix Glycyrrhizae.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, specifically comprise the following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein frying under the conditions of 90 DEG C respectively are taken 20min;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter the water immersion 60min under the conditions of 0 DEG C of 10 mass multiple;
(4) it takes raw tortoise plastron therein and raw turtle shell to add the water of 8 mass multiples, decocts 15min under 120 DEG C of heating conditions, obtain To medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate 80min;
(6) then the medical fluid heat for obtaining step (5) continues to heat 45min under the conditions of 90 DEG C and constantly stir to boiling It mixes;Then medical fluid will be obtained by filtering, respectively obtain medicament and the dregs of a decoction;
(7) water of 8 mass multiples is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively To medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed to 120 mesh, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained The Chinese medicine composition of the treatment gastric cancer.
Embodiment 3
The embodiment of the present invention 3 discloses a kind of Chinese medicine composition for treating gastric cancer, which is characterized in that specifically includes following weight Measure the component of part:250g fingered citron, the 230g dried immature fruit of citron orange, 230g santal, 220g Radix Curcumae, 180g tsaoko, 250g rhizome of chuanxiong, the 150g root of three-nerved spicebush, 250g rhizoma corydalis, 250g cattail pollen, 10~20 parts of olibanums, 230g myrrh, 200g rhizoma nardostachyos, 250g hairyvein agrimony, 250g flos caryophylli, 180g parts of akebiaes, 260g Concretio Silicea Bambusae, the full Snakegourd Fruit of 190g, 240g rhizoma polygonati, 260g radix polygonati officinalis, lotus root on 250g stone, 240g roud cardamon seed, 270g radices trichosanthis, 250g endothelium corneum gigeriae galli, 210g cuttlebone, the 260g seed of Oriental arborvitae, 280g fructus cannabis, 290g aspongopus, 250g semen coicis, The raw turtle shell of 270g Radix Notoginseng, 260g blood clam, 260g Chinese yam, 350g raw tortoise plastron, 320g and 180g Radix Glycyrrhizae.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, specifically comprise the following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein frying under the conditions of 80 DEG C respectively are taken 30min;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter the water immersion 70min under the conditions of 10 DEG C of 8~10 mass multiple;
(4) it takes raw tortoise plastron therein and raw turtle shell to add the water of 7 mass multiples, decocts 20min under 100 DEG C of heating conditions, obtain To medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate 60min;
(6) then the medical fluid heat for obtaining step (5) continues to heat 28min under the conditions of 80 DEG C and constantly stir to boiling It mixes;Then medical fluid will be obtained by filtering, respectively obtain medicament and the dregs of a decoction;
(7) water of 7 mass multiples is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively To medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed to 150 mesh, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained The Chinese medicine composition of the treatment gastric cancer.
Embodiment 4
A kind of Chinese medicine composition for treating gastric cancer, specifically includes the component of following weight:20g fingered citron, the 20g dried immature fruit of citron orange, 20g wingceltis Perfume, 20g Radix Curcumae, 20g tsaoko, 20g rhizome of chuanxiong, the 15g root of three-nerved spicebush, 20g rhizoma corydalis, 20g cattail pollen, 15g olibanum, 15g myrrh, 20g are sweet Pine, 20g hairyvein agrimony, 20g flos caryophylli, 20g akebiae, 20g Concretio Silicea Bambusae, the full Snakegourd Fruit of 20g, 20g rhizoma polygonati, 20g radix polygonati officinalis, on 20g stone Lotus root, 20g roud cardamon seed, 20g radices trichosanthis, 20g endothelium corneum gigeriae galli, 20g cuttlebone, the 20g seed of Oriental arborvitae, 30g pockmarks benevolence, 20g aspongopus, 20g The raw turtle shell of semen coicis, 20g Radix Notoginseng, 30g blood clam, 20g Chinese yam, 30g raw tortoise plastron, 30g and 15g Radix Glycyrrhizae.
The invention also discloses a kind of preparation methods of Chinese medicine composition for treating gastric cancer, specifically comprise the following steps:
(1) each raw material is weighed according to a kind of Chinese medicine composition for treating gastric cancer as described above, it is spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein frying under the conditions of 85 DEG C respectively are taken 40min;
(3) then by the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam Jing Guo frying and fingered citron, santal, strongly fragrant Gold, rhizome of chuanxiong, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in radix polygonati officinalis ginseng, stone, and add Enter the water immersion 120min under the conditions of 15 DEG C of 10 mass multiple;
(4) it takes raw tortoise plastron therein and raw turtle shell to add the water of 8 mass multiples, decocts 30min under 120 DEG C of heating conditions, obtain To medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate 80min;
(6) then the medical fluid heat for obtaining step (5) continues to heat 50min under the conditions of 90 DEG C and constantly stir to boiling It mixes;Then medical fluid will be obtained by filtering, respectively obtain medicament and the dregs of a decoction;
(7) water of 8 mass multiples is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively To medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed to 200 mesh, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained The Chinese medicine composition of the treatment gastric cancer.
Comparative example 1
Chinese medicine material in embodiment 4 is replaced with:20g fingered citron, 20g santal, 20g tsaoko, the 15g root of three-nerved spicebush, 20g cattail pollen, 15g myrrh, 20g hairyvein agrimony, 20g akebiae, the full Snakegourd Fruit of 20g, 20g radix polygonati officinalis, 20g roud cardamon seed, 20g endothelium corneum gigeriae galli, 20g cedar seed The raw turtle shell of benevolence, 20g aspongopus, 20g Radix Notoginseng, 20g Chinese yam, 30g and 15g Radix Glycyrrhizae;Other conditions are constant.
Comparative example 2
Chinese medicine material in embodiment 4 is replaced with:The 20g dried immature fruit of citron orange, 20g Radix Curcumae, 20g rhizome of chuanxiong, 20g rhizoma corydalis, 15g cream Perfume, 20g rhizoma nardostachyos, 20g flos caryophylli, 20g Concretio Silicea Bambusae, 20g rhizoma polygonati, lotus root, 20g radices trichosanthis, 20g cuttlebone, 30g pockmarks on 20g stone The raw turtle shell of benevolence, 20g aspongopus, 20g semen coicis, 20g Radix Notoginseng, 30g blood clam, 20g Chinese yam, 30g raw tortoise plastron, 30g and 15g are sweet Grass;Other conditions are constant.
One, effect detection
1, test principle:Rat cell has many identical places compared with human body cell, the tumour cell of rat also with Close, thus simulated environment of the tumour cell of available rat as human carcinoma's situation of human body, carrys out test sample to cancer Test effect.The size variation amount of its effect rat ascites tumor abdominal circumference and tumor weight is stated, ascites tumor abdominal circumference variable quantity More or tumor weight variable quantity is bigger, shows that drug is stronger to the therapeutic effect of cancer;Similarly, ascites tumor abdominal circumference changes Amount is less or tumor weight variable quantity is smaller, shows that drug is stronger to the preventive effect of cancer.
2, test method:Firstly, 70 adult male SD rats (180g-200g) are taken, it is swollen to the S180 of rat inoculation 106 Oncocyte inoculates mode using 1ml syringe and is inoculated into rat and goes forward armpit.It is randomly divided into 7 groups, respectively blank control Group, Examples 1 to 4 and comparative example 1~2;
Blank control group:Other compositions are not added in rat feed, so raising 14 days;
Embodiment 1-4 and comparative example 1~2:It according to feed and Chinese medicine composition mass ratio is 4 in rat feed:1 addition Corresponding Chinese medicine composition, so raising 14 days.
Observe each group rat before medication with medication 14 days after S180 ascites tumor abdominal circumference size variation situation, and with Before medicine with medication 14 days after tumor weight size variation situation, the results are shown in Table 1, and the test result uses ± standard deviation (X ± SD) is indicated.
Table 1
It can obviously learn that the Chinese medicine composition that 1-4 of the embodiment of the present invention is prepared can have by data in above-mentioned table 1 Effect inhibits the growth and breeding of tumour cell in rat, it is possible thereby to illustrate Chinese medicine composition disclosed by the invention for treatment Cancer has obvious effects on.Compared to comparative example 1-2, embodiment 1-4 ascites tumor abdominal circumference size variation and tumor weight size become Change significantly higher, the present invention realizes the effect for treating gastric cancer by mutuals cooperation between raw material.
Two, illustrate therapeutic effect of the invention by clinical case
1, case 1:Mr. Yang (because of the non-name names of individual privacy) gender male, the age 70 years old
Condition-inference:Due to dysphagia, gastral cavilty is swollen pain in September in 2012 13 days institute of traditional Chinese medicine of Shanxi Province carry out gastroscope, Pathologic finding, as a result diagnostic result is Grades of Gastric Cardia Adenocarcinoma.
Patient's body syntexis, sallow complexion, epigastric distending pain, dysphagia, mouth parched and tongue scorched, just knot, fatigue and asthenia, tongue it is red, Tongue fur is light white, the thin string of arteries and veins.
Treatment method:Take a kind of Chinese medicine composition for treating gastric cancer that embodiment 1 is prepared, three times a day, breakfast Latter hour takes 120ml-150ml, p.prand one and half takes 120ml, takes 120ml-150ml before just before going to bed;Adhere to Medication 5 months.
Treatment results:On March 29th, 2013 in the barium agent inspection of Shanxi worker's hospital of chemical fertilizer factory, inspection result shows cardia No abnormality seen.On May 17th, 2015 carries out electronic endoscopy in Shanxi Province Changzhi City Qin County, as the result is shown no abnormality seen.
2, case 2:Mrs Wang (because of the non-name names of individual privacy) gender female, the age 70 years old
Condition-inference:Initial symptoms are gastric area throe, violent swelling, and night is extremely obvious;Gasteremphraxis pain, back after 20 days Aching and tired, night cannot sleep, occur hematochezia, strip-like-shaped suddenly.Pathologic finding is carried out in 2 months 2002 9 the people's hospital of Heibei Ru, Inspection result is shown:(previous anastomotic) sees suspicious cancer cell.
Medical history:Suffered from cardia cancer before 8 years, fully recover after operative treatment, is always maintained at after operation good.
Treatment method:Take a kind of Chinese medicine composition for treating gastric cancer that embodiment 1 is prepared, three times a day, breakfast Latter hour takes 120ml-150ml, p.prand one and half takes 120ml, takes 120ml-150ml before just before going to bed.
Treatment results:Adhere to taking one month, for tongue body without indentation, the lymph lump of right clavicle and right axillary nest starts impotence contracting; After adhering to medication five months, above-mentioned illness is substantially achieved effective control;Do not occur disease relapse after curing 16 years.
3, case 3:Mr. Yang (because of the non-name names of individual privacy) gender male, the age 70 years old
Condition-inference:Since dysphagia, vague epigastralgia are in Lingchuan county people's hospital x-ray inspection on December 4th, 2000 (inspection Directory enquiry:4222) display is checked:" gastritis, however not excluded that body of stomach cancer ";It is treated by nearly bimestrial observation, the state of an illness gradually starts to dislike Change, is eventually led to and do not taken even a drop of water into full liquid food by half liquid food, the severe pain of gastral cavilty portion;In on 2 23rd, 2001 Changzhi medicine Affiliated hospital of institute gastrocopy (gastroscope number 4687) display:Anaemia, stomach is with bile regurgitation, pathologic finding (medical record number 1213) result It is shown as:Grades of Gastric Cardia Adenocarcinoma
Treatment method:Take a kind of Chinese medicine composition for treating gastric cancer that embodiment 1 is prepared, three times a day, breakfast Latter hour takes 120ml-150ml, p.prand one and half takes 120ml, takes 120ml-150ml before just before going to bed;Adhere to Medication 5 months.
Treatment results:It was checked on August 14th, 2001 in Lingchuan county people's hospital and Changzhi City peace hospital, x-ray rabat Inspection is shown:Cardia body of stomach has no obvious lesion.Do not occur disease relapse after curing 8 years.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other The difference of embodiment, the same or similar parts in each embodiment may refer to each other.For device disclosed in embodiment For, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is said referring to method part It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one The widest scope of cause.

Claims (9)

1. a kind of Chinese medicine composition for treating gastric cancer, which is characterized in that specifically include the component of following parts by weight:15~30 parts of Buddhists Hand, 15~30 parts of dried immature fruit of citron oranges, 15~30 portions of santals, 15~30 portions of Radix Curcumaes, 15~30 parts of tsaokos, 15~30 parts of rhizome of chuanxiongs, 10~25 parts The root of three-nerved spicebush, 15~30 parts of rhizoma corydalis, 15~30 parts of cattail pollens, 10~20 parts of olibanums, 10~25 parts of myrrhs, 15~25 parts of rhizoma nardostachyos, 15 ~30 portions of hairyvein agrimonies, 15~30 portions of flos caryophyllis, 15~30 parts of akebiaes, 15~30 parts of Concretio Silicea Bambusaes, 15~30 parts of full Snakegourd Fruits, 15~ 30 parts of rhizoma polygonatis, 15~30 portions of radix polygonati officinalis, lotus root, 15~30 parts of roud cardamon seeds, 15~30 portions of radices trichosanthis, 15~30 portions of chickens on 15~30 parts of stones Interior gold, 15~30 portions of cuttlebones, 15~30 parts of seed of Oriental arborvitaes, 25~40 parts of fructus cannabis, 15~30 portions of aspongopus, 15~30 portions of coix lacryma-jobi Benevolence, 15~30 portions of Radix Notoginseng, 25~35 parts of blood clams, 15~30 portions of Chinese yams, 20~40 parts of raw tortoise plastrons, 20~40 parts of raw turtle shells and 10 ~20 portions of Radix Glycyrrhizaes.
2. a kind of Chinese medicine composition for treating gastric cancer according to claim 1, which is characterized in that specifically include following weight The component of part:
20 portions of fingered citrons, 20 parts of dried immature fruit of citron oranges, 20 portions of santals, 20 portions of Radix Curcumaes, 20 parts of tsaokos, 20 parts of rhizome of chuanxiongs, 15 parts of roots of three-nerved spicebush, 20 parts prolong recklessly Rope, 20 parts of cattail pollens, 15 parts of olibanums, 15 parts of myrrhs, 20 parts of rhizoma nardostachyos, 20 portions of hairyvein agrimonies, 20 portions of flos caryophyllis, 20 parts of akebiaes, 20 Part Concretio Silicea Bambusae, 20 parts of full Snakegourd Fruits, 20 parts of rhizoma polygonatis, 20 portions of radix polygonati officinalis, lotus root, 20 parts of roud cardamon seeds, 20 portions of radices trichosanthis, 20 portions of chickens on 20 parts of stones Interior gold, 20 portions of cuttlebones, 20 parts of seed of Oriental arborvitaes, 30 parts of fructus cannabis, 20 portions of aspongopus, 20 parts of semen coicis, 20 portions of Radix Notoginseng, 30 parts of corrugations Son, 20 portions of Chinese yams, 30 parts of raw tortoise plastrons, 30 parts of raw turtle shells and 15 portions of Radix Glycyrrhizaes.
3. a kind of preparation method for the Chinese medicine composition for treating gastric cancer, which is characterized in that specifically comprise the following steps:
(1) a kind of Chinese medicine composition for treating gastric cancer according to claim 1 or 2 weighs each raw material, spare;
(2) dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam therein is taken to carry out frying respectively;
(3) then by Jing Guo frying the dried immature fruit of citron orange, tsaoko, cattail pollen, the seed of Oriental arborvitae, semen coicis and Chinese yam and fingered citron, santal, Radix Curcumae, river Vault, the root of three-nerved spicebush, rhizoma corydalis, olibanum, myrrh, rhizoma nardostachyos, hairyvein agrimony, flos caryophylli, akebiae, Concretio Silicea Bambusae, full Snakegourd Fruit, rhizoma polygonati, radix polygonati officinalis Lotus root, roud cardamon seed, radices trichosanthis, Ji Zhongjin, cuttlebone, pockmarks benevolence, aspongopus, blood clam and Radix Glycyrrhizae mixing in ginseng, stone, and water is added It impregnates;
(4) it takes raw tortoise plastron therein and raw turtle shell to add water, then decocts and obtain medical fluid;
(5) step (3) is mixed with the medical fluid that step (4) obtains, continues to impregnate;
(6) medical fluid that step (5) obtains first is heated to boiling, then proceedes to heat under agitation;Medicine will finally be obtained Liquid respectively obtains medicament and the dregs of a decoction by filtering;
(7) water is added in the dregs of a decoction that step (6) obtains, then the repeatedly operation of step (6), respectively obtains medicament and the dregs of a decoction;
(8) Radix Notoginseng is crushed, then uniformly mixing with the medicament that step (6) and step (7) obtain can be obtained the treatment stomach The Chinese medicine composition of cancer.
4. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly the water that 0~15 DEG C of 8~10 mass multiple is added in (3) impregnates 60~120min.
5. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly the water of 6~8 mass multiples is added in (4), 15~30min is then decocted under 90~120 DEG C of heating conditions.
6. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly continue 40~80min of immersion in (5).
7. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly continue to heat 45-50min under the conditions of 75~90 DEG C after boiling in (6).
8. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly the water of 6~8 mass multiples is added in (7).
9. a kind of preparation method of Chinese medicine composition for treating gastric cancer according to claim 3, which is characterized in that the step Suddenly Radix Notoginseng is crushed to 200 mesh~120 mesh in (8).
CN201810973476.1A 2018-08-24 2018-08-24 A kind of Chinese medicine composition and preparation method thereof for treating gastric cancer Pending CN108853431A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324648A (en) * 2000-05-18 2001-12-05 盛智化 Quick-acting gastropathy treating medicine powder and its prepn.
CN106860841A (en) * 2017-04-06 2017-06-20 陈海林 A kind of Chinese medicine composition for treating stomach cancer
JP2018021049A (en) * 2012-06-22 2018-02-08 トラスティーズ・オブ・ダートマス・カレッジ Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324648A (en) * 2000-05-18 2001-12-05 盛智化 Quick-acting gastropathy treating medicine powder and its prepn.
JP2018021049A (en) * 2012-06-22 2018-02-08 トラスティーズ・オブ・ダートマス・カレッジ Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders
CN106860841A (en) * 2017-04-06 2017-06-20 陈海林 A kind of Chinese medicine composition for treating stomach cancer

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