CN108852856A - Application of the Epigallo-catechin gallate (EGCG) in orthodontic art - Google Patents

Abstract

The present invention discloses a kind of application of Epigallo-catechin gallate (EGCG) in orthodontic art, it is related to pharmaceutical technology field, i.e. using Epigallo-catechin gallate (EGCG) as preventing the active constituent of tooth Demineralization to be added in the enamel adhesive of bracket used in orthodontic art, compared with prior art, Epigallo-catechin gallate (EGCG) is added in bonding agent used in bracket by the present invention in correction art, can effectively reduce bacterial plaque accumulation around fixed orthodontic patient's bracket and reduce hickie incidence.

Description

Application of Epigallocatechin Gallate in Orthodontics

technical field

The invention relates to the technical field of medicine, in particular to the application of epigallocatechin gallate in orthodontics.

Background technique

White spot lesion (WSL) is a common side effect of traditional fixed correction, with an incidence rate of 2%-96%, and men are more than women. Leukoplakia generally occurs around the lip brackets, especially as fine white lines on the surface of the enamel, and may be accompanied by caries in severe cases. The microscopic manifestation of leukoplakia is enamel demineralization, which develops rapidly, and in the case of poor oral hygiene, demineralization of the enamel surface can be observed in only four weeks to form leukoplakia. During traditional orthodontic treatment, brackets need to be bonded to the labial surface of the teeth. After bonding the brackets, the self-cleaning effect of the teeth is reduced, the difficulty of brushing teeth is increased, and plaque is easy to adhere around the brackets. The above reasons will lead to an increase in the number of bacteria on the tooth surface, especially Streptococcus mutans and Lactobacillus. The acid production of these bacteria leads to a decrease in the pH of the enamel surface, demineralization, and in severe cases, caries on the tooth surface. The change in tooth color caused by leukoplakia can affect the effect of orthodontic surgery, cause oral aesthetic problems, and it is difficult to recover after orthodontic appliances are removed.

From band bonding to bracket bonding, orthodontics has experienced revolutionary development. Different adhesives, bonding base designs, acid etching methods, and bonding materials have been continuously researched and developed. At present, the clinical enamel bonding mainly adopts the full-etch bonding system. Through 37% phosphoric acid etching, a pit-like structure is formed on the surface of the enamel, and the micromechanical lock formed with the resin provides adhesion. In order to prevent the occurrence of leukoplakia, at present, the methods used clinically to deal with leukoplakia mainly include preventive methods, mainly including oral hygiene education, using various fluorine-containing products, chlorhexidine, controlling acid etching time, and applying resin and glass containing antibacterial materials. Ion-improved resin adhesives, etc. However, personal oral care and the use of fluorine-containing products require the cooperation of patients. The use of resins containing antibacterial materials and glass ionomer-modified resin adhesives has certain clinical effects, but leukoplakia is still one of the common clinical orthodontic complications. Therefore, exploring more effective drugs and prevention methods is still one of the current research directions.

Contents of the invention

The problem to be solved by the present invention is to provide an application scheme of epigallocatechin gallate in orthodontics, which can effectively reduce the incidence of demineralization and leukoplakia around brackets in clinical orthodontic patients.

In order to solve the above-mentioned technical problems, the technical solution adopted in the present invention is: adding epigallocatechin gallate as an active ingredient to prevent tooth demineralization into the enamel binder of the bracket used in orthodontics .

Epigallocatechin gallate of the present invention is a kind of polyphenolic monomer extracted from green tea, has antibacterial, anti-oxidation, anti-inflammatory and anti-tumor effects, and low biological toxicity; it cannot directly Instead of killing bacteria, it inhibits the activity of bacterial dehydrogenase, thereby inhibiting the process of bacterial acid production, reducing the pH drop on the tooth surface, and preventing the demineralization of the enamel surface and the occurrence of caries.

Due to the adoption of the technical solution of the present invention, compared with the prior art, the beneficial effect is: the present invention adds epigallocatechin gallate to the adhesive used in brackets in orthodontics, It can effectively reduce the accumulation of bacterial plaque around the brackets of fixed orthodontic patients and reduce the incidence of leukoplakia.

Detailed ways

The present invention will be further described below in conjunction with specific examples, but the technical scope of the present invention is not limited by these examples.

Patient selection: 50 volunteers were selected, and according to the random principle, the volunteers were divided into left-half-mouth experimental group, right-half-mouth control group or right-half-mouth experimental group and left-half-mouth control group to form self-control.

Test method: prepare an adhesive containing 2mg/ml epigallocatechin gallate, the experimental group uses the adhesive in the process of bonding brackets, and the control group uses no epigallocatechin gallate Ester adhesive of the same brand. Before the start of the experiment, supragingival cleaning was performed on each volunteer to remove dental calculus in the mouth, etc., and the plaque index was adjusted to the same baseline. According to the grouping situation, the brackets were bonded for each volunteer. When bonding the brackets, pay attention to scraping off the excess resin around the brackets. Except for the addition of epigallocatechin gallate, factors such as bracket brand, adhesive resin, and adhesive must be completely consistent, and all steps should be performed by the same doctor. After the bracket bonding was completed, oral hygiene education was given to each patient, and the patients were told to use the Bass method of brushing teeth, and a uniform brand of toothbrush and toothpaste was distributed.

Check method and result:

The Quigley-Hein modified Turesky plaque index was used to determine the plaque index and demineralization index of the anterior teeth. Remove the arch wire and accessories in the patient's mouth before the examination, instruct the patient to rinse and dry, and record according to the following criteria:

(1) Demineralization index:

0: no demineralization, no enamel caries leukoplakia;

1: Mild demineralization, white demineralized areas can be seen, but the surface structure of the enamel is not damaged;

2: Moderate demineralization, white demineralized areas can be seen, and the enamel surface is rough, but no restorative treatment is required;

3: Severe demineralization, white demineralized areas can be seen and the enamel is damaged, and repair treatment is required;

4: Cavities.

(2) Plaque index:

0: no plaque;

1: There is discontinuous plaque on the gingival margin;

2: There is continuous plaque less than 1mm in the gingival margin;

3: There are continuous plaques larger than 1 mm but less than 1/3 of the tooth surface;

4: The plaque area exceeds 1/3 but less than 2/3;

5: The plaque area exceeds 2/3.

The plaque index and demineralization index of patients were checked and recorded at 4 weeks, 3 months, 6 months, and 12 months. The results are shown in Table 1-Table 4:

Table 1: Plaque and demineralization index recording table (4 weeks, average value)

Table 2: Plaque and demineralization index recording table (3 months, average value)

Table 3: Plaque and demineralization index recording table (6 months, average value)

Table 4: Plaque and demineralization index recording table (12 months, average value)

As can be seen from the comparative tests in Table 1-Table 4, there are significant differences in plaque index and demineralization index between the experimental group and the control group. It is concluded that in orthodontics, adding epigallocatechin gallate to the adhesive used in brackets can effectively reduce the accumulation of plaque around the brackets and reduce the incidence of white spots in patients with fixed orthodontics.

Claims (1)

1. application of a kind of Epigallo-catechin gallate (EGCG) in orthodontic art, it is characterized in that by epi-nutgall catechu Plain gallate is as the enamel for preventing the active constituent of tooth Demineralization to be added to bracket used in clinic orthodontic art In binder.