CN108837181A - A kind of bionical collagem membrane and preparation method thereof of high intensity - Google Patents
A kind of bionical collagem membrane and preparation method thereof of high intensity Download PDFInfo
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
- C08J9/286—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum the liquid phase being a solvent for the monomers but not for the resulting macromolecular composition, i.e. macroporous or macroreticular polymers
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- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/36—After-treatment
- C08J9/365—Coating
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- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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Abstract
The invention discloses a kind of bionical collagem membranes and preparation method thereof of high intensity, include the following steps：A. bionical epithelium substrate is chosen first；B. the preparation of fusions is carried out after the completion of the step a again；C. after the completion of step b, blender is recycled, the fusion of bionical epithelium substrate is carried out；D. after the completion of step c, then the preparation of surfactant is carried out；E. after the completion of step d, the preparation of bionical collagem membrane is carried out again, in the preparation process for carrying out bionical collagem membrane, by on conventional preparation method, by the way that bionical epithelium substrate is first fabricated to weaker zone, matching surface activating agent is coated again, porous effect increases adsorptivity, the organic content of entire bionical collagem membrane is set to increase by 22%, bionical epithelium substrate can be obtained collagen sponge by -40 DEG C of environment combination vacuum freeze drying by elder generation, again by pre-freeze at -20 DEG C, compacting forms weaker zone, change the biological nature of bionical epithelium substrate, to form high intensity, convenient for promoting the use of.
Description
Technical field
The present invention relates to bionical collagen technical field of membrane, the bionical collagem membrane of specially a kind of high intensity and its preparation side
Method.
Background technique
Biomembrane not only has very high selectivity and transit dose, also can be carried out various catalysis reactions and conversion function, and
It can run at normal temperatures and pressures.The highest artificial membrane of efficiency at present, the also only centesimal level of biomembrane, and collagen conduct
As a kind of natural macromolecular material, the tissue repair regeneration field more and more weight by domestic and international experts and scholars is being guided
Depending on.This is mainly due to the main components that collagen is extracellular matrix, have good biocompatibility, can promote the viscous of cell
Attached, proliferation and differentiation.In certain application processes, collagen tissue repair material not only wants that cell growth can be successfully booted up, heavier
What is wanted is to provide a stable space for new tissue growth, while preventing perienchyma's cell as a kind of physical barriers
Grow into, thus achieve the purpose that promote defective region tissue reconstruction.
Currently, bionical collagem membrane can be prepared manually, but in actual use, in the preparation to bionical collagem membrane
Cheng Zhong, existing bionical epithelium substrate is because of its physical characteristic, during cooperating fusions to be coated, adhesion rate drop
It is low, practical carrying amount is affected, secondly in the bionical lower situation of collagen film strength, just reduces its use scope and longevity
Life makes to promote being limited, these are all physical presence and urgent problem.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the defects of the prior art, provide a kind of bionical collagem membrane of high intensity
And preparation method thereof, bionical epithelium substrate is fabricated to weaker zone by first, then matching surface activating agent is coated, porous effect
Fruit increases adsorptivity, so that the organic content of entire bionical collagem membrane is increased by 22%, increases the effect used, can pass through first
Bionical epithelium substrate obtains collagen sponge by -40 DEG C of environment combination vacuum freeze drying, then by pre-freeze, pressure at -20 DEG C
System forms weaker zone, changes the biological nature of bionical epithelium substrate, to form high intensity, increases ductility, chemical stabilization
Property it is stronger, convenient for promote the use of.
To solve the above problems, the present invention provides the following technical solutions：A kind of bionical collagem membrane of high intensity and its preparation
Method includes the following steps：
A. bionical epithelium substrate is chosen first；
B. the preparation of fusions is carried out after the completion of the step a again；
C. after the completion of step b, blender is recycled, the fusion of bionical epithelium substrate is carried out；
D. after the completion of step c, then the preparation of surfactant is carried out；
E. after the completion of step d, then the preparation of bionical collagem membrane is carried out；
F. after the completion of step e, finally bionical collagem membrane is sealed.
As a kind of preferred embodiment of the invention, in the step a；Bionical epithelium substrate is sodium hyaluronate 30%, glue
Former 48%, hinge hyaluronic acid 17%, chitosan 5%.
As a kind of preferred embodiment of the invention, in the step b：Fusions are 5 grams of Cer NS, oligopeptides 20
Gram, 6 grams of acetyl group tetrapeptide, 7 grams of dipeptides, 15 grams of choline glycerophosphatide, 12 grams of ubiquinone, 4 grams of phytosphingosine.
As a kind of preferred embodiment of the invention, in the step c：Blender is vortex stirring mechanism, needs to cooperate
Gnotobasis, fusion process 20min, the rotation of motor is 3200r/min in the process, and wherein temperature is 20 DEG C -35 DEG C, then
Stand 30min.
As a kind of preferred embodiment of the invention, in the step d：Surfactant is：Carboxylic acid 13%, sulfonic acid
16%, sulfuric acid 11%, amino 24%, hydroxyl 8%, amide groups 20%, ehter bond 18%.
As a kind of preferred embodiment of the invention, the step e further includes preparation method, and step includes as follows.
S1, first prepare collagen acetic acid molten night, by the acetic acid solution of bionical epithelium substrate at-40 DEG C pre-freeze 10-14
Hour, vacuum freeze drying obtains collagen sponge；
After S2, step S1, by collagen sponge at 100 DEG C-160 DEG C, reacted 8-14 hours under vacuum, then merging
It is impregnated 4-9 hours in object, needs to carry out pre- thermal agitation to fusions before immersion；
After S3, step S2, washed, after washing pre-freeze 16 hours or more at -20 DEG C, freeze-drying；Compacting
It forms to get weaker zone is arrived；
After S4, step S3, in the surface coating surface activating agent of weaker zone, then low temperature drying, sterilizing are carried out.
Compared with prior art, beneficial effects of the present invention are as follows：
A kind of bionical collagem membrane and preparation method thereof of high intensity of the present invention, it is thin by the way that first bionical epithelium substrate is fabricated to
Loose layer, then matching surface activating agent are coated, and porous effect increases adsorptivity, make the organic content of entire bionical collagem membrane
Increase by 22%, increases the effect used, bionical epithelium substrate can be done by -40 DEG C of environment combination vacuum refrigeration by elder generation
It is dry to obtain collagen sponge, then weaker zone is formed by pre-freeze, compacting at -20 DEG C, the biological nature of bionical epithelium substrate is changed,
To form high intensity, ductility is increased, chemical stability is stronger, convenient for promoting the use of.
Specific embodiment
The present invention provides a kind of technical solution：A kind of bionical collagem membrane and preparation method thereof of high intensity, including following step
Suddenly：
A. bionical epithelium substrate is chosen first；
B. the preparation of fusions is carried out after the completion of the step a again；
C. after the completion of step b, blender is recycled, the fusion of bionical epithelium substrate is carried out；
D. after the completion of step c, then the preparation of surfactant is carried out；
E. after the completion of step d, then the preparation of bionical collagem membrane is carried out；
F. after the completion of step e, finally bionical collagem membrane is sealed.
In the step a；Bionical epithelium substrate is sodium hyaluronate 30%, collagen 48%, hinge hyaluronic acid 17%, chitosan
5%.
In the step b：Fusions are 5 grams of Cer NS, 20 grams of oligopeptides, 6 grams of acetyl group tetrapeptide, 7 grams of dipeptides, glycerol
15 grams of phosphocholine, 12 grams of ubiquinone, 4 grams of phytosphingosine.
In the step c：Blender is vortex stirring mechanism, need to cooperate gnotobasis, fusion process 20min, process
The rotation of middle motor is 3200r/min, and wherein temperature is 20 DEG C -35 DEG C, then stands 30min.
In the step d：Surfactant is：Carboxylic acid 13%, sulfonic acid 16%, sulfuric acid 11%, amino 24%, hydroxyl 8%,
Amide groups 20%, ehter bond 18%.
The step e further includes preparation method, and step includes as follows；
S1, first prepare collagen acetic acid molten night, by the acetic acid solution of bionical epithelium substrate at-40 DEG C pre-freeze 10-14
Hour, vacuum freeze drying obtains collagen sponge；
After S2, step S1, by collagen sponge at 100 DEG C-160 DEG C, reacted 8-14 hours under vacuum, then merging
It is impregnated 4-9 hours in object, needs to carry out pre- thermal agitation to fusions before immersion；
After S3, step S2, washed, after washing pre-freeze 16 hours or more at -20 DEG C, freeze-drying；Compacting
It forms to get weaker zone is arrived；
After S4, step S3, in the surface coating surface activating agent of weaker zone, then low temperature drying, sterilizing are carried out.
In bionical collagem membrane of a kind of high intensity and preparation method thereof, first by the way that first bionical epithelium substrate is fabricated to
Weaker zone, then matching surface activating agent are coated, and porous effect increases adsorptivity, contain entire the organic of bionical collagem membrane
Amount increases by 22%, increases the effect used, secondly bionical epithelium substrate can be passed through by elder generation -40 DEG C of environment combination vacuum
Freeze-drying obtains collagen sponge, then forms weaker zone by pre-freeze, compacting at -20 DEG C, changes the life of bionical epithelium substrate
Object characteristic increases ductility to form high intensity, and chemical stability is stronger, convenient for promoting the use of.
Now bionical collagem membrane progress is commonly used in a kind of bionical collagem membrane of made high intensity and certain market through the invention
Experimental Comparison, test process are as follows；
1, using stretching device, post-tensioning is fixed to bionical collagem membrane, is terminated with being fractured into, measurement original volume and drawing
Volume difference is stretched, to calculate extension size.
2, compatibility test basin is placed in 1L distilled water, carries out throwing stirring to embodiment, stands after five minutes, according to percentage
Calculate melt water.
3, cooperate modulus of rupture device such as modulus of rupture analyzer, embodiment upper and lower ends are firmly squeezed to the component simultaneously
Pressure, measurement how many MPA under high voltage intensity can be broken, and you can get it can bear how many MPA.
4, embodiment hydrophobing agent uses Indirect Determination, in high accuracy, highly sensitive method measurement high purity material
Various impurity contents, purity of the percentage as the high purity material of surveyed total impurities is then subtracted from test substance.
Test data is as follows：
| Ductility/% | Adsorptivity/M2 | The modulus of rupture/MPA | The pre-hardening period/H | |
| Embodiment 1 | 5.6 | 4.3 | 26 | ≥3 |
| Reinspection | 5.3 | 4.1 | 27 | ≥2.8 |
| Comparative example 1 | 7.5 | 5.6 | 42 | ≥6 |
Through Experimental comparison, the bionical collagem membrane of high intensity made by the present invention a kind of with high adsorption, high intensity and
The good feature of ductility.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from spirit of the invention or
In the case where essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention
It is interior.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although referring to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features.It is all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of bionical collagem membrane and preparation method thereof of high intensity, it is characterised in that：Include the following steps：
A. bionical epithelium substrate is chosen first；
B. the preparation of fusions is carried out after the completion of the step a again；
C. after the completion of step b, blender is recycled, the fusion of bionical epithelium substrate is carried out；
D. after the completion of step c, then the preparation of surfactant is carried out；
E. after the completion of step d, then the preparation of bionical collagem membrane is carried out；
F. after the completion of step e, finally bionical collagem membrane is sealed.
2. a kind of bionical collagem membrane and preparation method thereof of high intensity according to claim 1, it is characterised in that：The step
In rapid a；Bionical epithelium substrate is sodium hyaluronate 30%, collagen 48%, hinge hyaluronic acid 17%, chitosan 5%.
3. a kind of bionical collagem membrane and preparation method thereof of high intensity according to claim 1, it is characterised in that：The step
In rapid b：Fusions are 5 grams of Cer NS, 20 grams of oligopeptides, 6 grams of acetyl group tetrapeptide, 7 grams of dipeptides, 15 grams of choline glycerophosphatide, general
12 grams of quinone, 4 grams of phytosphingosine.
4. a kind of bionical collagem membrane and preparation method thereof of high intensity according to claim 1, it is characterised in that：The step
In rapid c：Blender is vortex stirring mechanism, need to cooperate gnotobasis, fusion process 20min, the rotation of motor in the process is
3200r/min, wherein temperature is 20 DEG C -35 DEG C, then stands 30min.
5. a kind of bionical collagem membrane and preparation method thereof of high intensity according to claim 1, it is characterised in that：The step
In rapid d：Surfactant is：Carboxylic acid 13%, sulfonic acid 16%, sulfuric acid 11%, amino 24%, hydroxyl 8%, amide groups 20%, ether
Key 18%.
6. a kind of bionical collagem membrane and preparation method thereof of high intensity according to claim 1, it is characterised in that：The step
Rapid e further includes preparation method, and step includes as follows；
S1, the acetic acid molten night for preparing collagen first, by the acetic acid solution of bionical epithelium substrate, pre-freeze 10-14 is small at-40 DEG C
When, vacuum freeze drying obtains collagen sponge；
After S2, step S1, by collagen sponge at 100 DEG C-160 DEG C, reacted 8-14 hours under vacuum, then in fusions
It impregnates 4-9 hours, needs to carry out pre- thermal agitation to fusions before immersion；
After S3, step S2, washed, after washing pre-freeze 16 hours or more at -20 DEG C, freeze-drying；Compression moulding,
Obtain weaker zone；
After S4, step S3, in the surface coating surface activating agent of weaker zone, then low temperature drying, sterilizing are carried out.
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| CN201810638530.7A CN108837181A (en) | 2018-06-20 | 2018-06-20 | A kind of bionical collagem membrane and preparation method thereof of high intensity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110743044A (en) * | 2019-11-23 | 2020-02-04 | 北京银河巴马生物技术股份有限公司 | Dental bone-guided regenerated collagen membrane and preparation method thereof |
Citations (3)
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|---|---|---|---|---|
| CN101954126A (en) * | 2010-09-26 | 2011-01-26 | 华南理工大学 | Method for preparing bionic modified collagen tissue repair material |
| JP2011212437A (en) * | 2010-03-17 | 2011-10-27 | Gunze Ltd | Sustained release base material containing dance protein and method for manufacturing sustained release base material |
| CN104684593A (en) * | 2012-06-12 | 2015-06-03 | 昊图细胞有限公司 | Method for producing collagen film and its use |
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2018
- 2018-06-20 CN CN201810638530.7A patent/CN108837181A/en active Pending
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|---|---|---|---|---|
| JP2011212437A (en) * | 2010-03-17 | 2011-10-27 | Gunze Ltd | Sustained release base material containing dance protein and method for manufacturing sustained release base material |
| CN101954126A (en) * | 2010-09-26 | 2011-01-26 | 华南理工大学 | Method for preparing bionic modified collagen tissue repair material |
| CN104684593A (en) * | 2012-06-12 | 2015-06-03 | 昊图细胞有限公司 | Method for producing collagen film and its use |
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| 李国英等: "《胶原化学》", 30 April 2013, 北京：中国轻工业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110743044A (en) * | 2019-11-23 | 2020-02-04 | 北京银河巴马生物技术股份有限公司 | Dental bone-guided regenerated collagen membrane and preparation method thereof |
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