CN108815570A - Gel hemostatic material and preparation method thereof - Google Patents
Gel hemostatic material and preparation method thereof Download PDFInfo
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- CN108815570A CN108815570A CN201810745398.XA CN201810745398A CN108815570A CN 108815570 A CN108815570 A CN 108815570A CN 201810745398 A CN201810745398 A CN 201810745398A CN 108815570 A CN108815570 A CN 108815570A
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- hemostatic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- General Health & Medical Sciences (AREA)
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Abstract
The present invention provides a kind of gel hemostatic material and preparation method thereof, gel hemostatic material includes hemostasis gel substrate and the drug that is supported on the hemostasis gel substrate, and by weight, gel base is made by following components：20-30 parts of gelfoam, 10-20 parts of polylactic acid polymer, 15-25 parts of chitosan, 5-8 parts of zeolite, drug are one or more of vitamin C, chitosan, Antifibrinolytic agents and promotion coagulation factor pharmacological activation.The mass fraction of load of the drug in the hemostasis gel substrate is 3-8%.Gel hemostatic material of the invention prepares simplicity, and antibacterial and anthemorrhagic performance are good, and comfort is good, are applicable to a variety of medical applications.
Description
Technical field
The present invention relates to field of medical materials, and in particular to a kind of gel hemostatic material and preparation method thereof.
Background technique
In field of medical materials, antibacterial and hemostatic material are to apply and its widely, either minor operation or large-scale
Operation requires these material matings to complete.There are anthemorrhagic performance is undesirable and permeability is bad etc. for current hemostatic material
Disadvantage, so that its application is limited.In addition, also some hemostatic materials are capable of providing preferable hemostatic, but material in the market
Matter comfort is poor and at high cost.Thus, although for hemostatic material research compare it is more, but these be not still able to satisfy show
There is the demand of medical material, still needs effectively to improve hemostatic material.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of gel hemostatic material, with good anthemorrhagic performance, and
Preparation is easy, and using comfortable, anti-microbial property is also fine.
To achieve the above object, the invention adopts the following technical scheme：
On the one hand, the present invention provides a kind of gel hemostatic material, including hemostasis gel substrate and be supported on it is described only
Drug in blood clotting gum base materials, by weight, the gel base are made by following components：20-30 parts of gelfoam, polylactic acid
10-20 parts of polymer, 15-25 parts of chitosan, 5-8 parts of zeolite, the drug are vitamin C, chitosan, antifibrinolysis
One or more of drug and promotion coagulation factor pharmacological activation, load of the drug in the hemostasis gel substrate
Mass fraction is 3-8%.
Preferably, Antifibrinolytic agents are Aprotinin or amion acetic acid.
Preferably, promoting coagulation factor pharmacological activation is vitamin K1 or minirin.
Preferably, by weight, the hemostasis gel substrate is made by following components：20 parts of gelfoam, polylactic acid poly
10 parts of object of conjunction, 15 parts of chitosan and 5 parts of zeolite.
Preferably, by weight, the hemostasis gel substrate is made by following components：30 parts of gelfoam, polylactic acid poly
20 parts of object of conjunction, 25 parts of chitosan and 8 parts of zeolite.
Preferably, by weight, the hemostasis gel substrate is made by following components：15 parts of gelfoam, polylactic acid poly
15 parts of object of conjunction, 20 parts of chitosan and 6 parts of zeolite.
Preferably, polylactic acid polymer is polylactic acid poly glycol copolymer.
On the other hand, the present invention also provides the preparation method of above-mentioned gel hemostatic material, include the following steps：It weighs
Trostin M is made in 20-30 parts of gelfoam, 10-20 parts of polylactic acid polymer, 15-25 parts of chitosan, 5-8 parts of zeolite after mixing
The substrate is immersed in drug solution 0.5-1 hours by gum base materials, obtains the gel hemostatic material.
By above-mentioned technical proposal, compared with prior art, the present invention is had the following advantages that：It is solidifying that the present invention provides one kind
Glue hemostatic material, preparation is simple, and anthemorrhagic performance is good, and uses more comfortably, at low cost, can be widely used.Pass through
Hemostasis gel substrate loading drug, drug can slowly penetrate into site of injury to be treated, play anastalsis while antibacterial,
Hemostatic material of the invention is suitable for a plurality of types of patients.
Specific embodiment
Specific embodiments of the present invention will be described in further detail below.It should be understood that following embodiment is only used
In illustrating the present invention, limitation of the scope of the invention but should not be understood as.
Embodiment 1
Embodiment 1 provides a kind of gel hemostatic material, including hemostasis gel substrate and is supported on the hemostasis gel substrate
On drug, by weight, the gel base is made by following components：20 parts of gelfoam, 10 parts of polylactic acid polymer, shell
15 parts and 5 parts of zeolite of glycan, the drug is vitamin C, chitosan and Aprotinin, and the drug is in the hemostasis gel substrate
In load mass fraction be 3%.Polylactic acid polymer is polylactic acid poly glycol copolymer.
Embodiment 2
Embodiment 2 provides a kind of gel hemostatic material, including hemostasis gel substrate and is supported on the hemostasis gel substrate
On drug, by weight, the hemostasis gel substrate is made by following components：15 parts of gelfoam, polylactic acid polymer 15
Part, 20 parts of chitosan and 6 parts of zeolite, the drug are vitamin C, chitosan and vitamin K1, and the drug is in the hemostasis
The mass fraction of load in gel base is 5%.Polylactic acid polymer is polylactic acid poly glycol copolymer.
Embodiment 3
Embodiment 3 provides a kind of gel hemostatic material, including hemostasis gel substrate and is supported on the hemostasis gel substrate
On drug, by weight, the hemostasis gel substrate is made by following components：15 parts of gelfoam, polylactic acid polymer 15
Part, 20 parts of chitosan and 6 parts of zeolite, the drug are vitamin C, minirin and amion acetic acid, and the drug is described
The mass fraction of load in hemostasis gel substrate is 8%.Polylactic acid polymer is polylactic acid poly glycol copolymer.
The preparation method of the gel hemostatic material of embodiment 1-3 includes the following steps：Weigh gelfoam, poly lactic acid polymerized
Object, chitosan, zeolite are made hemostasis gel substrate, the substrate are immersed in drug solution 0.5-1 hours, is obtained after mixing
Gel hemostatic material.Gel hemostatic material preparation method in each embodiment is essentially identical, and difference is only that soaking time difference,
With the difference of specific ingredient.In embodiment 1, substrate impregnates 0.5 hour in drug solution, and in embodiment 2, substrate is molten in drug
It is impregnated 1 hour in liquid, in embodiment 3, substrate impregnates 1.5 hours in drug solution.
Performance test shows that gel hemostatic material anthemorrhagic performance of the invention is good, has good antibacterial and anthemorrhagic performance.
Suitable for a variety of occasions, and simplicity is prepared, at low cost, comfort is good, and use is safe, thus has a good application prospect.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (8)
1. a kind of gel hemostatic material, which is characterized in that including hemostasis gel substrate and be supported on the hemostasis gel substrate
Drug, by weight, the gel base is made by following components：20-30 parts of gelfoam, polylactic acid polymer 10-20
Part, 15-25 parts of chitosan, 5-8 parts of zeolite, the drug are vitamin C, chitosan, Antifibrinolytic agents and promotion
One or more of coagulation factor pharmacological activation, the mass fraction that the drug loads in the hemostasis gel substrate are 3-
8%.
2. gel hemostatic material according to claim 1, it is characterised in that：The Antifibrinolytic agents are suppression peptide
Enzyme or amion acetic acid.
3. gel hemostatic material according to claim 1, it is characterised in that：The promotion coagulation factor pharmacological activation is dimension
Raw element K1 or minirin.
4. gel hemostatic material according to claim 1, which is characterized in that by weight, the hemostasis gel substrate by
Following components is made：20 parts of gelfoam, 10 parts of polylactic acid polymer, 15 parts of chitosan and 5 parts of zeolite.
5. gel hemostatic material according to claim 1, which is characterized in that by weight, the hemostasis gel substrate by
Following components is made：30 parts of gelfoam, 20 parts of polylactic acid polymer, 25 parts of chitosan and 8 parts of zeolite.
6. gel hemostatic material according to claim 1, which is characterized in that by weight, the hemostasis gel substrate by
Following components is made：15 parts of gelfoam, 15 parts of polylactic acid polymer, 20 parts of chitosan and 6 parts of zeolite.
7. gel hemostatic material according to claim 1, it is characterised in that：The polylactic acid polymer is polylactic acid poly second
Diol copolymer.
8. a kind of preparation method of gel hemostatic material described in claim 1, which is characterized in that include the following steps：It weighs
Trostin M is made in 20-30 parts of gelfoam, 10-20 parts of polylactic acid polymer, 15-25 parts of chitosan, 5-8 parts of zeolite after mixing
The substrate is immersed in drug solution 0.5-1 hours by gum base materials, obtains the gel hemostatic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810745398.XA CN108815570A (en) | 2018-07-09 | 2018-07-09 | Gel hemostatic material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810745398.XA CN108815570A (en) | 2018-07-09 | 2018-07-09 | Gel hemostatic material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108815570A true CN108815570A (en) | 2018-11-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810745398.XA Withdrawn CN108815570A (en) | 2018-07-09 | 2018-07-09 | Gel hemostatic material and preparation method thereof |
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| Country | Link |
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| CN (1) | CN108815570A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435263A (en) * | 2003-03-05 | 2003-08-13 | 成都拓泰医药科技开发有限公司 | Hematostatic gel |
| CN104784742A (en) * | 2015-04-24 | 2015-07-22 | 浙江大学 | Hemostasis dressing and preparation method thereof |
| CN107261199A (en) * | 2017-06-28 | 2017-10-20 | 西北大学 | A kind of preparation method of the gel dressing containing Zeolite hemostatic |
-
2018
- 2018-07-09 CN CN201810745398.XA patent/CN108815570A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435263A (en) * | 2003-03-05 | 2003-08-13 | 成都拓泰医药科技开发有限公司 | Hematostatic gel |
| CN104784742A (en) * | 2015-04-24 | 2015-07-22 | 浙江大学 | Hemostasis dressing and preparation method thereof |
| CN107261199A (en) * | 2017-06-28 | 2017-10-20 | 西北大学 | A kind of preparation method of the gel dressing containing Zeolite hemostatic |
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Application publication date: 20181116 |