CN108815568A - A kind of full-service fluid medical hydrogel dressings absorbed by the body and preparation method thereof - Google Patents
A kind of full-service fluid medical hydrogel dressings absorbed by the body and preparation method thereof Download PDFInfo
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- 239000012530 fluid Substances 0.000 title claims abstract description 35
- 239000000017 hydrogel Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 239000000284 extract Substances 0.000 claims abstract description 51
- 108010022355 Fibroins Proteins 0.000 claims abstract description 40
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 39
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 39
- 239000000243 solution Substances 0.000 claims abstract description 36
- 239000011259 mixed solution Substances 0.000 claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000000499 gel Substances 0.000 claims abstract description 30
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 20
- 230000002364 anti-haemorrhagic effect Effects 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 18
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000018102 proteins Nutrition 0.000 claims abstract description 17
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 17
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 17
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 238000010992 reflux Methods 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- 238000009777 vacuum freeze-drying Methods 0.000 claims abstract description 11
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000011347 resin Substances 0.000 claims abstract description 9
- 229920005989 resin Polymers 0.000 claims abstract description 9
- 230000008961 swelling Effects 0.000 claims abstract description 9
- 230000001052 transient effect Effects 0.000 claims abstract description 9
- 235000019441 ethanol Nutrition 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 239000004964 aerogel Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 23
- 208000027418 Wounds and injury Diseases 0.000 description 23
- 239000000463 material Substances 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 3
- 229940093265 berberine Drugs 0.000 description 3
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002121 nanofiber Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZUKLFFYDSALIQW-MSUKCBDUSA-N Iridoid glycoside Chemical compound [H][C@]12CC[C@H](C(O)=O)[C@@]1([H])[C@H](OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2 ZUKLFFYDSALIQW-MSUKCBDUSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- -1 atoleine Chemical compound 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229930182489 iridoid glycoside Natural products 0.000 description 1
- 150000008145 iridoid glycosides Chemical class 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of full-service fluid medical hydrogel dressings absorbed by the body and preparation method thereof, includes the following steps：After keel powder and stamen nelumbini powder are mixed, it is added to refluxing extraction 3 times, combined extract, evaporated under reduced pressure in ethanol solution and obtains Chinese medical extract；Chinese medical extract is added in warm water, after mixing, crosses macroporous resin column, after ethanol water rinses, the antibacterial anti hemorrhagic extract that is purified；It stirs to form protein mixed solution by fibroin solutions are added in soybean protein aqueous solution, protein mixed solution is added dropwise to the mixed solution of glutaraldehyde and cetyl trimethylammonium bromide, after heating stirring, it is placed in transient gel in the biochemical cultivation case of constant temperature, obtains soybean protein/fibroin gel；By soybean protein/fibroin gel after vacuum freeze drying, it is impregnated in the antibacterial anti hemorrhagic extract of purifying immediately, sufficient standing swelling obtains full-service fluid medical hydrogel dressings absorbed by the body.
Description
Technical field
The invention belongs to medical dressing field of material technology, and in particular to a kind of full-service fluid doctor absorbed by the body
With aerogel dressing and preparation method thereof.
Background technique
Medical wound dressing is to be covered on wound or other damaging tissue's surface protection wounds to prevent trauma surface infestation and dehydration
Medical material.The process repaired according to wound tissue can be broadly divided into following three phases：The formation of wound inflammation, it is newborn
The reconstruction of granulation tissue and the reconstruction of bio-matrix, during wound is repaired, medical dressing can protect damaged skin, and
Diffusate and noxious material are absorbed simultaneously, allows to carry out gas exchanges inside and outside the surface of a wound, create an ideal reparation ring for wound
Border, but also have effects that prevent tissue infection, promote healing.
Currently, medical dressing mainly includes medical absorbent cotton and absorbent gauze, there is reticular structure abundant, wound is seeped
Liquid has certain absorbability out, and geology is soft, can sufficiently be combined with the surface of a wound, can promote wound healing, and source is extensively at low cost,
Preparation method is simple, but relatively wet healing environment cannot be provided for the surface of a wound, and granulation tissue is easily accessible deposited in growth
In the mesh of material, increase the difficulty of subsequent removal, or even cause the rupture again of wound, and dressing mesh is larger, bacterium is more held
Easily invasion causes infection.The composite activated carbon fibre of class containing only iridoid glycoside disclosed in Chinese patent CN 107158446A
Hemostasis, antibacterial, promoting healing medical dressing, Preparation method and use, which includes only iridoid glycoside class, ten
Six alkyl trimethyl ammonium chlorides, polyvinyl alcohol/collagen, matrix and medicinal active Carbon fibe, mesostroma include octadecyl alcolol,
SDS, albolene, Buddhist nun moor ethyl ester gold, atoleine, glycerol, beeswax, vegetable oil, sodium carboxymethylcellulose and sodium benzoate water
Solution, after the material in addition to medicinal active Carbon fibe is mixed, irradiation sterilization obtains solvent/ointment type dressing, then will be molten
Agent/ointment type dressing is coated in activated carbon fibre, dry, radiosterilization, obtains inhibition hemostasis, the control suitable for the various surface of a wound
Trauma surface infestation processed promotes wound healing.A kind of ingredient berberine containing Chinese medicine antibacterial disclosed in Chinese patent CN 105854068A
Sodium alginate nano fiber medical dressing and preparation method thereof, by Chinese medicine antibacterial ingredient berberine and sodium alginate and polyvinyl alcohol
After mixing, discontinuous degassing obtains electrostatic spinning solution, and ingredient berberine containing Chinese medicine antibacterial then is prepared through Static Spinning ounce
Sodium alginate nano fiber medical dressing.By the above-mentioned prior art it is found that having by being extracted from plants with antibacterial, hemostasis
Effect ingredient, which is added in medical dressing, assigns its functionality, but the functional material that the performance of medical dressing is not only loaded with it has
It closes, also has very big relationship with the material-structure of the carrier of dressing, therefore, functional material is sufficiently combined with the advantage of base-material
Just it is able to satisfy the reparation requirement of complicated type wound.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of full-service fluid medical aquogels absorbed by the body to apply
Keel and stamen nelumbini are that raw material extraction purification obtains the extract that there is antibacterial anti-inflammatory to stop blooding by material and preparation method thereof, abundant to obtain
It penetrates into the porous material containing fibroin and soybean protein, makes porous material gelation again, obtain absorbed by the body
Full-service fluid medical hydrogel dressings.
In order to solve the above technical problems, the technical scheme is that：
A kind of preparation method of full-service fluid medical hydrogel dressings absorbed by the body, includes the following steps：
(1) after mixing keel powder and stamen nelumbini powder, refluxing extraction 3 times in the ethanol solution of 65-70% are added to, are closed
And extracting solution, evaporated under reduced pressure obtain Chinese medical extract；
(2) Chinese medical extract by step (1) preparation is added in warm water, after mixing, macroporous resin column is crossed, through ethyl alcohol
After aqueous solution rinses, the antibacterial anti hemorrhagic extract that is purified；
(3) soybean protein is added to the water, is stirred to after being completely dissolved, fibroin solutions are added and continue stirring formation
Protein mixed solution is added dropwise to the mixed solution of glutaraldehyde and cetyl trimethylammonium bromide by protein mixed solution, heating
After stirring, it is placed in transient gel in the biochemical cultivation case of 37 DEG C of constant temperature, obtains soybean protein/fibroin gel；
(4) soybean protein/fibroin gel of step (3) preparation is taken out, is impregnated immediately after vacuum freeze drying
In the antibacterial anti hemorrhagic extract of the purifying of step (2) preparation, sufficient standing swelling obtains full-service fluid absorbed by the body
Medical hydrogel dressings.
As a preferred embodiment of the above technical solution, in the step (1), the mass ratio of keel powder and stamen nelumbini powder is 0.3-
0.6:1。
As a preferred embodiment of the above technical solution, in the step (1), the time of refluxing extraction is 60-90min.
As a preferred embodiment of the above technical solution, in the step (2), the temperature of warm water is 40-60 DEG C.
As a preferred embodiment of the above technical solution, in the step (2), the 25-30% of ethyl alcohol in ethanol water.
As a preferred embodiment of the above technical solution, in the step (3), the mass ratio of soybean protein and fibroin is 1:1-
3。
As a preferred embodiment of the above technical solution, in the step (3), glutaraldehyde accounts for the content of total system and is in mixed solution
45-80mmol/L, the content that cetyl trimethylammonium bromide accounts for total system is 35-40mmol/L.
As a preferred embodiment of the above technical solution, in the step (3), the temperature of heating stirring is 60-70 DEG C, and the time is
15-30min。
As a preferred embodiment of the above technical solution, in the step (4), the temperature of vacuum freeze drying is -20~-80 DEG C,
Time is 1-3d.
As a preferred embodiment of the above technical solution, any medical water-setting of full-service fluid absorbed by the body
The full-service fluid medical hydrogel dressings absorbed by the body of the preparation method preparation of glue dressing.
Compared with prior art, the invention has the advantages that：
(1) main body of full-service fluid medical hydrogel dressings absorbed by the body prepared by the present invention is fibroin
And soybean protein, fibroin and soybean protein are all made of amino acid, and the porous gel of fibroin and soybean protein
Good permeability, contact not only comfortable ventilating with the surface of a wound as dressing, but also can be absorbed by the body, make fibroin and soybean
The porous gel of albumen can long duration of action and surface of a wound surface connect for a long time as the absorption of nutrient ingredients of the surface of a wound without worrying
Stripping problem after touch, in addition, also containing in full-service fluid medical hydrogel dressings absorbed by the body prepared by the present invention
There is the plant extracts of keel and stamen nelumbini, the dry rhizome of keel can be clearing heat and detoxicating, anti-inflammatory analgesic, and stamen nelumbini has antibacterial anti hemorrhagic
Effect, therefore, two kinds of Chinese medicines, which are combined, makes hydrogel have effects that antibacterial anti-inflammatory hemostasis, by Chinese medical extract and porous gel
Material combines, and can more be conducive to the environment of the permanent safety and comfort for the surface of a wound, be conducive to the reparation of the surface of a wound.
(2) full-service fluid medical hydrogel dressings absorbed by the body prepared by the present invention have comfortable ventilative saturating
Wet performance is conducive to adjust surface of a wound temperature and humidity appropriate, cuts the Chinese medical extract contained in aerogel dressing and advantageously ensure that wound
Face is not by the infection of extraneous bacterium, it is most important that and aerogel dressing prepared by the present invention can be fully absorbed by the surface of a wound, therefore this
Invent preparation full-service fluid medical hydrogel dressings can the protection surface of a wound from beginning to end repairing phase, using effect is excellent
It is different.
Specific embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative examples and explanation of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1：
It (1) is 0.3 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 65% ethanol solution and returns
Stream extracts 3 times, each refluxing extraction 60min, and combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 40 DEG C of warm water, after mixing, macroporous resin column is crossed, through 25% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:1, be added fibroin solutions continue stirring forms protein mixed solution, by protein mixed solution be added dropwise to glutaraldehyde and
The mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 45mmol/L,
The content that cetyl trimethylammonium bromide accounts for total system is 35mmol/L, at 60 DEG C after heating stirring 15min, is placed in 37 DEG C
Constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 1d, is taken out, is impregnated in immediately pure at -20 DEG C
The antibacterial anti hemorrhagic extract of change, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Embodiment 2：
It (1) is 0.6 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 70% ethanol solution and returns
Stream extracts 3 times, each refluxing extraction 90min, and combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 60 DEG C of warm water, after mixing, macroporous resin column is crossed, through 30% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:3, be added fibroin solutions continue stirring forms protein mixed solution, by protein mixed solution be added dropwise to glutaraldehyde and
The mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 80mmol/L,
The content that cetyl trimethylammonium bromide accounts for total system is 40mmol/L, at 70 DEG C after heating stirring 30min, is placed in 37 DEG C
Constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 3d, is taken out, is impregnated in immediately pure at -80 DEG C
The antibacterial anti hemorrhagic extract of change, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Embodiment 3：
It (1) is 0.5 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 68% ethanol solution and returns
Stream extracts 3 times, each refluxing extraction 85min, and combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 55 DEG C of warm water, after mixing, macroporous resin column is crossed, through 28% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:1-3, addition fibroin solutions continue stirring and form protein mixed solution, and protein mixed solution is added dropwise to glutaraldehyde
With the mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 65mmol/
L, the content that cetyl trimethylammonium bromide accounts for total system is that 38mmol/L is placed in 37 at 67 DEG C after heating stirring 20min
DEG C constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 2d, is taken out, is impregnated in immediately pure at -60 DEG C
The antibacterial anti hemorrhagic extract of change, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Embodiment 4：
It (1) is 0.45 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 68% ethanol solution
Refluxing extraction 3 times, each refluxing extraction 75min, combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 55 DEG C of warm water, after mixing, macroporous resin column is crossed, through 29% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:1.5, addition fibroin solutions continue stirring and form protein mixed solution, and protein mixed solution is added dropwise to glutaraldehyde
With the mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 60mmol/
L, the content that cetyl trimethylammonium bromide accounts for total system is that 38mmol/L is placed in 37 at 68 DEG C after heating stirring 25min
DEG C constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 2.5d, is taken out, is impregnated in immediately at -50 DEG C
The antibacterial anti hemorrhagic extract of purifying, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Embodiment 5：
It (1) is 0.3 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 70% ethanol solution and returns
Stream extracts 3 times, each refluxing extraction 60min, and combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 60 DEG C of warm water, after mixing, macroporous resin column is crossed, through 25% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:3, be added fibroin solutions continue stirring forms protein mixed solution, by protein mixed solution be added dropwise to glutaraldehyde and
The mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 45mmol/L,
The content that cetyl trimethylammonium bromide accounts for total system is 40mmol/L, at 60 DEG C after heating stirring 30min, is placed in 37 DEG C
Constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 1d, is taken out, is impregnated in immediately pure at -80 DEG C
The antibacterial anti hemorrhagic extract of change, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Embodiment 6：
It (1) is 0.6 by mass ratio:After 1 keel powder and stamen nelumbini powder mixing, it is added in 65% ethanol solution and returns
Stream extracts 3 times, each refluxing extraction 90min, and combined extract, evaporated under reduced pressure obtains Chinese medical extract.
(2) Chinese medical extract is added in 40 DEG C of warm water, after mixing, macroporous resin column is crossed, through 30% ethanol water
After solution rinses, the antibacterial anti hemorrhagic extract that is purified.
(3) soybean protein is added to the water, is stirred to after being completely dissolved, according to the quality of soybean protein and fibroin
Than being 1:1, be added fibroin solutions continue stirring forms protein mixed solution, by protein mixed solution be added dropwise to glutaraldehyde and
The mixed solution of cetyl trimethylammonium bromide, the content that wherein glutaraldehyde accounts for total system in mixed solution is 80mmol/L,
The content that cetyl trimethylammonium bromide accounts for total system is 35mmol/L, at 70 DEG C after heating stirring 15min, is placed in 37 DEG C
Constant temperature biochemical cultivation case in transient gel, obtain soybean protein/fibroin gel.
(4) soybean protein/fibroin gel after vacuum freeze drying 3d, is taken out, is impregnated in immediately pure at -20 DEG C
The antibacterial anti hemorrhagic extract of change, sufficient standing swelling, obtains full-service fluid medical hydrogel dressings absorbed by the body.
Through detecting, the porosity of the full-service fluid medical hydrogel dressings absorbed by the body of embodiment 1-6 preparation,
Water lock, antibiotic property, hemostatic and absorbability result are as follows：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Porosity (%) | 46 | 59 | 52 | 53 | 49 | 57 |
| Water retention (%) | 78 | 83 | 79 | 80 | 81 | 82 |
| Antibiotic rate (%) | 89 | 93 | 92 | 90 | 92 | 90 |
| Bleeding stopping period shortening rate (%) | 38 | 46 | 45 | 42 | 40 | 39 |
| Absorbable rate (%) | 96 | 97 | 98 | 96 | 97 | 97 |
As seen from the above table, the porosity of full-service fluid medical hydrogel dressings absorbed by the body prepared by the present invention
Moderate, water lock is good, and hemostatic and antibacterial anti-inflammatory effects are good, also has good absorbability energy.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of preparation method of full-service fluid medical hydrogel dressings absorbed by the body, which is characterized in that including with
Lower step：
(1) after mixing keel powder and stamen nelumbini powder, refluxing extraction 3 times in the ethanol solution of 65-70% are added to, merging mentions
Liquid is taken, evaporated under reduced pressure obtains Chinese medical extract；
(2) Chinese medical extract by step (1) preparation is added in warm water, after mixing, crosses macroporous resin column, water-soluble through ethyl alcohol
After liquid rinses, the antibacterial anti hemorrhagic extract that is purified；
(3) soybean protein is added to the water, is stirred to after being completely dissolved, addition fibroin solutions continue stirring and form albumen
Protein mixed solution is added dropwise to the mixed solution of glutaraldehyde and cetyl trimethylammonium bromide, heating stirring by mixed solution
Afterwards, it is placed in transient gel in the biochemical cultivation case of 37 DEG C of constant temperature, obtains soybean protein/fibroin gel；
(4) soybean protein/fibroin gel of step (3) preparation is taken out after vacuum freeze drying, is impregnated in step immediately
Suddenly the antibacterial anti hemorrhagic extract of the purifying of (2) preparation, sufficient standing swelling, it is medical to obtain full-service fluid absorbed by the body
Aerogel dressing.
2. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (1), the mass ratio of keel powder and stamen nelumbini powder is 0.3-0.6:1.
3. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (1), the time of refluxing extraction is 60-90min.
4. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (2), the temperature of warm water is 40-60 DEG C.
5. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (2), the 25-30% of ethyl alcohol in ethanol water.
6. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (3), the mass ratio of soybean protein and fibroin is 1:1-3.
7. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (3), in mixed solution glutaraldehyde account for total system content be 45-80mmol/L, 16
The content that alkyl trimethyl ammonium bromide accounts for total system is 35-40mmol/L.
8. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (3), the temperature of heating stirring is 60-70 DEG C, time 15-30min.
9. a kind of preparation side of full-service fluid medical hydrogel dressings absorbed by the body according to claim 1
Method, it is characterised in that：In the step (4), the temperature of vacuum freeze drying is -20~-80 DEG C, time 1-3d.
10. a kind of described in any item systems of full-service fluid medical hydrogel dressings absorbed by the body of claim 1-9
The full-service fluid medical hydrogel dressings absorbed by the body of Preparation Method preparation.
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