CN108814771B - Two-leaf biological valve - Google Patents
Two-leaf biological valve Download PDFInfo
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- CN108814771B CN108814771B CN201810178531.8A CN201810178531A CN108814771B CN 108814771 B CN108814771 B CN 108814771B CN 201810178531 A CN201810178531 A CN 201810178531A CN 108814771 B CN108814771 B CN 108814771B
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- membrane
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- 239000012528 membrane Substances 0.000 claims description 47
- 238000009958 sewing Methods 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 5
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 230000008602 contraction Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 210000004165 myocardium Anatomy 0.000 abstract description 2
- 230000035790 physiological processes and functions Effects 0.000 abstract description 2
- 210000003709 heart valve Anatomy 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 210000002837 heart atrium Anatomy 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000000591 tricuspid valve Anatomy 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a two-leaf biological valve which comprises a lining ring, a diaphragm A, a diaphragm B, a positioning piece, a diaphragm A hanging piece and a diaphragm B hanging piece; the lining ring is in a quasi-circular shape; the diaphragm A and the diaphragm B are respectively provided with a diaphragm tip, and are provided with a diaphragm A hanging sheet and a diaphragm B hanging sheet, the diaphragm tips of the diaphragm A and the diaphragm B are fixed at one end of the lining ring by a fixing line after being overlapped, the diaphragm A hanging sheet and the diaphragm B hanging sheet are folded with a positioning sheet, and the positioning sheet is fixed at the other end of the lining ring through a positioning sheet binding edge, so that the two biological petals form a diaphragm A circular arc opening and a diaphragm B circular arc opening, an intersection port of the diaphragm A hanging sheet and the diaphragm B hanging sheet, and a diaphragm intersection port of the diaphragm A and the diaphragm B. The biological valve has reasonable design, simple manufacture and proper embedding condition, can be opened and closed at the valve ring and the joint of the two valve leaves simultaneously, provides maximized valve mouth area, can obviously reduce the occurrence of blood events, can reduce the noise of the two valve leaves simultaneously, enables the diastole and the contraction of cardiac muscle to be closer to the physiological state, and is easy to popularize and use.
Description
Technical Field
The invention belongs to the technical field of medical instruments, in particular to an instrument for heart valve surgery for replacing a diseased heart valve, and more particularly provides a two-leaf biological valve for replacing the function of a human heart valve.
Background
In vertebrates, the heart is a hollow muscular organ with four pump chambers: left and right atria and left and right ventricles, each with its own one-way valve. The synchronous pumping action of the left and right sides of the heart constitutes the cardiac cycle. The cycle begins with ventricular diastole, which is referred to as ventricular diastole. The prime power for promoting the blood of human body to flow and circulate the whole body is the contraction force of ventricular muscle, and the valve is opened and closed when the blood flows from the ventricle to the vein and flows back to the atrium in a one-way. The ventricular contraction is a power pump, the valve is a valve, the unidirectional circulation of blood flow is limited, once the heart valve is diseased, the opening and closing functions cannot be completed, and repair and replacement are required.
In cardiac surgery, diseased valves were replaced with prosthetic heart valves, beginning in the 1960 s, for over 50 years now, with both types of artificial biological and artificial mechanical valves. Mechanical valves are divided into single-lobe and two-lobe valves, and the single-lobe valve is almost abandoned in clinic due to non-central blood flow and excessive blood events. However, the mechanical valve needs to be taken with lifetime anticoagulant drugs, the influence of valve noise, the valve blockage caused by the inflammation of the artificial valve and the like are still the problems which are still difficult to solve.
① the joint grooves of the leaflets are all arranged in the ring wall, so that the double leaflets close in the cylinder shape, the shear force generated by the movement of the leaflet joints and the leaflets damages the blood components, and the events such as blood thrombosis and hemorrhage are easily caused;
② the difference between the cylindrical shape and the approximately elliptical shape of the tricuspid valve is obvious, which has great deformation obstacle effect on the anatomy reconstruction of the tricuspid valve;
③ the cylindrical design limits the effective area of the orifice, causing negative obstruction and negative impact on the myocardial contraction function;
④ the bivalve mechanical valve in the cylinder has three blood flow, which has negative effect of increasing energy consumption.
The two-leaf biological valve designed by the applicant can be opened and closed at the valve ring and the intersection of the two leaves at the same time, so that the maximized area of the leaf valve opening is provided, the occurrence of blood events can be remarkably reduced, simpler surgical implantation conditions are provided, the opening sound is reduced, the whole structure is novel, and the function is closer to the function of the heart valve leaf of a human body.
Disclosure of Invention
The purpose of the invention is as follows: the valve membrane sheet with two leaves and the like, which is simple in design, is provided for the heart valve surgery, the two leaves can be opened and closed simultaneously when the valve membrane sheet moves on the valve ring, and the shape state of the new generation biological valve which can reduce or does not use anticoagulant drugs can be completely changed. Provides a novel biological valve which is more in line with physiological requirements for heart valve surgical replacement.
The invention is realized by the following steps:
a two-leaf biological valve comprises a lining ring, a diaphragm A and a diaphragm B, and is characterized in that: also provided with a positioning plate, a membrane A hanging plate and a membrane B hanging plate; the lining ring is circular or quasi-circular; the diaphragm A and the diaphragm B are respectively provided with a diaphragm tip, and are provided with a diaphragm A hanging piece and a diaphragm B hanging piece, the diaphragm tips of the diaphragm A and the diaphragm B are overlapped and then sewn by a fixing wire, the diaphragm A hanging piece, the diaphragm B hanging piece and the positioning piece are folded, the positioning piece is fixed at the other end of the lining ring, and the two lobes of the diaphragm A and the diaphragm B form a diaphragm A and diaphragm B two-diaphragm intersection, a diaphragm A circular arc opening, a diaphragm B circular arc opening and an intersection of the diaphragm A hanging piece and the diaphragm B hanging piece.
Further, the areas of the diaphragm A and the diaphragm B are equal.
Further, the lengths of the straight edges of the film A and the film B are equal, and the overlapping width of the film A and the film B is 0.2-0.4 cm.
Furthermore, after the hanging piece A and the hanging piece B of the membrane are folded and overlapped with the positioning piece, the hanging piece positioning line is used for sewing and positioning, and the fixing line is used for sewing and fixing the binding root of the positioning piece A on the lining ring.
Furthermore, the height of the positioning piece is 1.8-2.0cm, the height of the positioning piece A is based on the fact that the arc opening of the diaphragm A and the arc opening of the diaphragm B are respectively overlapped with the lining ring, and the arc edges of the arc opening of the diaphragm A and the arc opening of the diaphragm B do not exceed the ring top surface of the lining ring.
Furthermore, the lining ring is provided with 2-4 composite limiting lines of the diaphragm A and the diaphragm B.
Furthermore, the shape of the arc edge of the arc opening of the diaphragm A and the arc edge of the arc opening of the diaphragm B is consistent with that of the arc edge of the lining ring.
The invention has the advantages and positive effects that:
1) the lining ring and the valve ring of the two-leaf biological valve are in elliptical shapes, and are arranged into two-leaf membranes, so that the two-leaf biological valve has areas closer to physiology and anatomy and a central blood flow state, the damage to blood is obviously reduced, and the diastole and contraction of cardiac muscle are closer to the physiological state.
2) The two-leaf membrane of the two-leaf biological valve has equal area, can move simultaneously under the action of the same pressure, and can be opened and closed simultaneously at the joint of the valve ring and the two-leaf valve, thereby providing the maximum valve mouth area, remarkably reducing the occurrence of blood events, simultaneously reducing the volume generated by the two-leaf valve and reducing the noise.
3) The two-leaf biological valve has the advantages of simple design, lower manufacturing cost, simpler operation implantation condition, contribution to the anatomical reconstruction of the heart valve, better adaptability to protecting the heart valve of a human body, reduction of the accumulation of metabolic substances in the valve leaf, prevention of calcification of the valve leaf, prolongation of the service life and easy popularization and use.
Drawings
FIG. 1: is a schematic top view structure diagram of a circular biological valve;
FIG. 2: is a schematic view of the top-down structure of the quasi-circular biological valve;
FIG. 3: is a schematic sectional structure diagram of the biological valve;
FIG. 4: is a structural diagram of the unfolded membrane material of the biological valve.
The attached drawings are as follows: 1-two-lobe valve, 2-backing ring, 3-membrane A circular arc opening, 4-membrane A, 5-positioning piece slit root, 6-membrane B, 7-composite limiting line, 8-membrane B circular arc opening, 9-two-membrane intersection, 10-membrane tip, 11-fixing line, 12-positioning piece foot, 13-suture line, 14-folding line, A-positioning piece, A4-membrane A hanging piece, A5-hanging piece positioning line, A6-membrane B hanging piece, 49-membrane A straight edge and 69-membrane B straight edge.
Detailed Description
The two-leaf bio-valve will be described in further detail with reference to the accompanying drawings and the following detailed description.
Example 1
As shown in fig. 1, 3 and 4, a circular two-leaf biological valve, wherein two leaves 1 are provided with a lining ring 2, a membrane A4, a membrane B6, a positioning sheet A, a membrane A hanging sheet A4 and a membrane B hanging sheet A); the two-lobe valve 1 is composed of a diaphragm A4 and a diaphragm B6, a diaphragm A4 and a diaphragm B6 are respectively provided with a diaphragm tip 10, a diaphragm A4 and a diaphragm B6 are respectively provided with a diaphragm A hanging piece A4 and a diaphragm B hanging piece A6, the diaphragm tips 10 of the diaphragm A4 and the diaphragm B6 are overlapped and then sewn by a fixing line 11, the diaphragm A hanging piece A4 and the diaphragm B hanging piece A6 are folded with a positioning piece A, the positioning piece A is fixed at the other end of a lining ring 2, and the two lobes of the diaphragm A4 and the diaphragm B6 form a two-diaphragm intersection 9 of the diaphragm A4 and the diaphragm B6, a diaphragm A arc opening 3, a diaphragm B arc opening 8 and an intersection of the diaphragm A hanging piece A4 and the diaphragm B hanging piece A6.
Further, the areas of the diaphragm A4 and the diaphragm B6 are equal.
Furthermore, the lengths of the straight edges of the membrane A4 and the membrane B6 are equal, the overlapping width of the straight edge 49 of the membrane A4 and the straight edge 69 of the membrane B6 is 0.2cm, and the membrane A hanging piece A4 and the membrane B hanging piece A6 are sewn by a sewing thread 13 to form a positioning piece A.
Furthermore, after the hanging piece A4 and the hanging piece B A6 of the membrane A and the locating piece A are folded and overlapped at the folding line 14, the hanging piece locating line A5 is used for sewing and locating, and the locating piece binding root 5 of the locating piece A is sewn and fixed at the other end of the locating piece A through the fixing line 11 to form the locating piece foot 12.
Furthermore, the height of the positioning piece A is 1.9cm, the height of the positioning piece A is based on the fact that the arc opening 3 of the diaphragm A and the arc opening 8 of the diaphragm B are respectively overlapped with the lining ring 2, and the arc edges of the arc opening 3 of the diaphragm A and the arc opening 8 of the diaphragm B do not exceed the ring top surface of the lining ring 2.
Furthermore, the liner ring 2 is provided with 3 composite limiting lines 7 of a diaphragm A4 and a diaphragm B6.
Further, the shape of the arc edge of the arc opening 3 of the diaphragm A and the arc edge of the arc opening 8 of the diaphragm B is consistent with that of the arc edge of the lining ring 2.
Example 2
As shown in fig. 2, 3 and 4, a round-like two-leaf biological valve, wherein two leaves 1 are provided with a lining ring 2, a membrane A4, a membrane B6, a positioning sheet A, a membrane A hanging sheet A4 and a membrane B hanging sheet A6); the two-lobe valve 1 is composed of a diaphragm A4 and a diaphragm B6, a diaphragm A4 and a diaphragm B6 are respectively provided with a diaphragm tip 10, a diaphragm A4 and a diaphragm B6 are respectively provided with a diaphragm A hanging piece A4 and a diaphragm B hanging piece A6, the diaphragm tips 10 of the diaphragm A4 and the diaphragm B6 are overlapped and then sewn by a fixing line 11, the diaphragm A hanging piece A4 and the diaphragm B hanging piece A6 are folded with a positioning piece A, the positioning piece A is fixed at the other end of a lining ring 2, and the two lobes of the diaphragm A4 and the diaphragm B6 form a two-diaphragm intersection 9 of the diaphragm A4 and the diaphragm B6, a diaphragm A arc opening 3, a diaphragm B arc opening 8 and an intersection of the diaphragm A hanging piece A4 and the diaphragm B hanging piece A6.
Further, the areas of the diaphragm A4 and the diaphragm B6 are equal.
Furthermore, the lengths of the straight edges of the membrane A4 and the membrane B6 are equal, the overlapping width of the straight edge 49 of the membrane A4 and the straight edge 69 of the membrane B6 is 0.3cm, and the membrane A hanging piece A4 and the membrane B hanging piece A6 are sewn by a sewing thread 13 to form a positioning piece A.
Furthermore, after the hanging piece A4 and the hanging piece B A6 of the membrane A and the locating piece A are folded and overlapped at the folding line 14, the hanging piece locating line A5 is used for sewing and locating, and the locating piece binding root 5 of the locating piece A is sewn and fixed at the other end of the locating piece A through the fixing line 11 to form the locating piece foot 12.
Furthermore, the height of the positioning piece A is 1.8cm, the height of the positioning piece A is based on the fact that the arc opening 3 of the diaphragm A and the arc opening 8 of the diaphragm B are respectively overlapped with the lining ring 2, and the arc edges of the arc opening 3 of the diaphragm A and the arc opening 8 of the diaphragm B do not exceed the ring top surface of the lining ring 2.
Further, the liner ring 2 is provided with 2 composite limiting lines 7 of a diaphragm A4 and a diaphragm B6.
Further, the shape of the arc edge of the arc opening 3 of the diaphragm A and the arc edge of the arc opening 8 of the diaphragm B is consistent with that of the arc edge of the lining ring 2.
During operation, the twelve points of the artificial valve of the operator and the twelve points of the human heart valve are sewed oppositely, and then the two sides are sewed with intermittent sewing threads, so that the mechanical valve is connected and sewed with the corresponding positions of the heart valve.
Claims (7)
1. The utility model provides a two leaf biological valves, sets up including backing ring (2), diaphragm A (4), diaphragm B (6), its characterized in that: also provided with a positioning sheet (A), a membrane A hanging sheet (A4) and a membrane B hanging sheet (A6); the lining ring (2) is circular or similar to circular; the diaphragm A (4) and the diaphragm B (6) are respectively provided with a diaphragm tip (10), the diaphragm A (4) and the diaphragm B (6) are provided with a diaphragm A hanging piece (A4) and a diaphragm B hanging piece (A6), the diaphragm tips (10) of the diaphragm A (4) and the diaphragm B (6) are overlapped and then sewn by a fixing line (11), the diaphragm A hanging piece (A4) and the diaphragm B hanging piece (A6) are folded with the positioning piece (A), the positioning piece (A) is fixed at the other end of the lining ring (2), and two lobes of the diaphragm A (4) and the diaphragm B (6) form a connecting port (9) of the diaphragm A (4) and the diaphragm B (6), a circular arc port (3) of the diaphragm A, a circular arc port (8) of the diaphragm B and a connecting ports of the diaphragm A hanging piece (A4) and the diaphragm B hanging piece (A6).
2. A bileaflet biological valve according to claim 1, wherein: the areas of the diaphragm A (4) and the diaphragm B (6) are equal.
3. A bileaflet biological valve according to claim 1, wherein: the lengths of the straight edges of the membrane A (4) and the membrane B (6) are equal, and the overlapping width of the membrane A (4) and the membrane B (6) is 0.2-0.4 cm.
4. A bileaflet biological valve according to claim 1, wherein: after the hanging piece A (A4) and the hanging piece B (A6) of the membrane A and the positioning piece (A) are folded and overlapped, the hanging piece positioning line (A5) is used for sewing and positioning, and the positioning piece binding root (5) of the positioning piece A is fixed on the lining ring (2) through the fixing line (11).
5. A bileaflet biological valve according to claim 4, wherein: the height of the positioning piece (A) is 1.8cm, the height of the positioning piece (A) is based on the fact that the circular arc opening (3) of the diaphragm A and the circular arc opening (8) of the diaphragm B are respectively overlapped with the lining ring (2), and the circular arc edges of the circular arc opening (3) of the diaphragm A and the circular arc opening (8) of the diaphragm B are not more than the ring top surface of the lining ring (2).
6. A bileaflet biological valve according to claim 5, wherein: the lining ring (2) is provided with 2-4 composite limiting lines (7) of a diaphragm A (4) and a diaphragm B (6).
7. A bileaflet biological valve according to claim 5, wherein: the shapes of the arc edges of the arc opening (3) of the diaphragm A and the arc opening (8) of the diaphragm B are consistent with the shape of the arc edge of the liner ring (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810178531.8A CN108814771B (en) | 2018-03-05 | 2018-03-05 | Two-leaf biological valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810178531.8A CN108814771B (en) | 2018-03-05 | 2018-03-05 | Two-leaf biological valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108814771A CN108814771A (en) | 2018-11-16 |
| CN108814771B true CN108814771B (en) | 2020-02-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810178531.8A Expired - Fee Related CN108814771B (en) | 2018-03-05 | 2018-03-05 | Two-leaf biological valve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108814771B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2217391Y (en) * | 1994-12-20 | 1996-01-17 | 北京市朝阳区新叶医疗器械厂 | Double-lamina artificial heart valve synthesized by silicon carbon |
| CN2433954Y (en) * | 2000-03-02 | 2001-06-13 | 张大幕 | Biparted heart valve |
| CN101010047A (en) * | 2004-02-27 | 2007-08-01 | 奥尔特克斯公司 | Prosthetic heart valve delivery systems and methods |
| CN103099687A (en) * | 2013-03-05 | 2013-05-15 | 广西医科大学第一附属医院 | Mitral valve mechanical valve with two valve leaflets in different sizes |
| CN103110464A (en) * | 2013-03-05 | 2013-05-22 | 广西医科大学第一附属医院 | Double knot different size tricuspid valve mechanical valve |
| CN103228231A (en) * | 2010-09-23 | 2013-07-31 | 科利柏心脏瓣膜有限责任公司 | Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane |
| CN203122679U (en) * | 2013-03-05 | 2013-08-14 | 广西医科大学第一附属医院 | Aorta valve mechanical valve with two different-sized leaflets |
| CN204219096U (en) * | 2014-09-16 | 2015-03-25 | 西南交通大学 | A kind of curved face type mechanical bilobed heart valve |
| CN107205816A (en) * | 2015-01-13 | 2017-09-26 | 杭州启明医疗器械有限公司 | bicuspid mitral valve |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050149181A1 (en) * | 2004-01-07 | 2005-07-07 | Medtronic, Inc. | Bileaflet prosthetic valve and method of manufacture |
-
2018
- 2018-03-05 CN CN201810178531.8A patent/CN108814771B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2217391Y (en) * | 1994-12-20 | 1996-01-17 | 北京市朝阳区新叶医疗器械厂 | Double-lamina artificial heart valve synthesized by silicon carbon |
| CN2433954Y (en) * | 2000-03-02 | 2001-06-13 | 张大幕 | Biparted heart valve |
| CN101010047A (en) * | 2004-02-27 | 2007-08-01 | 奥尔特克斯公司 | Prosthetic heart valve delivery systems and methods |
| CN103228231A (en) * | 2010-09-23 | 2013-07-31 | 科利柏心脏瓣膜有限责任公司 | Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane |
| CN103099687A (en) * | 2013-03-05 | 2013-05-15 | 广西医科大学第一附属医院 | Mitral valve mechanical valve with two valve leaflets in different sizes |
| CN103110464A (en) * | 2013-03-05 | 2013-05-22 | 广西医科大学第一附属医院 | Double knot different size tricuspid valve mechanical valve |
| CN203122679U (en) * | 2013-03-05 | 2013-08-14 | 广西医科大学第一附属医院 | Aorta valve mechanical valve with two different-sized leaflets |
| CN204219096U (en) * | 2014-09-16 | 2015-03-25 | 西南交通大学 | A kind of curved face type mechanical bilobed heart valve |
| CN107205816A (en) * | 2015-01-13 | 2017-09-26 | 杭州启明医疗器械有限公司 | bicuspid mitral valve |
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| Publication number | Publication date |
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| CN108814771A (en) | 2018-11-16 |
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