CN108785119A - A kind of amino acid bio complex enzyme toothpaste - Google Patents
A kind of amino acid bio complex enzyme toothpaste Download PDFInfo
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- CN108785119A CN108785119A CN201810934440.2A CN201810934440A CN108785119A CN 108785119 A CN108785119 A CN 108785119A CN 201810934440 A CN201810934440 A CN 201810934440A CN 108785119 A CN108785119 A CN 108785119A
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- amino acid
- complex enzyme
- bio complex
- acid bio
- enzyme toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of amino acid bio complex enzyme toothpastes.Amino acid bio complex enzyme toothpaste be by rubbing agent, moisturizer, surfactant, thickener, acid-base buffer agent, amino acid, enzyme preparation, taste-modifier, except stain whitening agent, essence, water are formulated by certain weight ratio.The amino acid bio complex enzyme toothpaste is with biological complex enzyme, amino acid Synergistic antimicrobial, form unique bacteriolyze Antibacterial Mechanism, its hetero-organization is not destroyed, does not generate drug resistance, effectively inhibits oral cavity harmful bacteria, reduce bacterium attachment, dental plaque index is reduced, while resisting erosion of the acid to tooth, is conducive to prevent dental caries, alleviate hemodia phenomenon, keeps tooth firmer.
Description
Technical field
The present invention relates to oral cleaning nursing article technical fields, and in particular to a kind of amino acid bio complex enzyme toothpaste.
Background technology
Tooth is organ most hard in human body, from institutional framework, by enamel, dentine, dental pulp, periodontium
Deng composition.
Enamel is covered in crown surfaces, is tissue most hard in human body, by 96% inorganic matter（Predominantly calcic and phosphorus
Phosphorite crystal）It is formed with a small amount of organic matter, although content of organics is seldom in enamel, to maintaining the biological characteristics of enamel
It plays an important role.Enamel is included there are two types of protein：Ameloblastin and glaze albumen, ameloblastin contain more proline and group ammonia
Acid, glaze albumen contain compared with pR60, glycine and aspartic acid, they participate in the growth of regulation and control crystal, in the mineralising of enamel
It is played an important role in forming process.
Dentine is the main part for constituting tooth, is made of matrix and dentinal tubule, wherein 70% is inorganic matter（It is main
To be calcium and phosphorus）, 20% is organic matter, and 10% is moisture.Organic principle is largely collagen, mainly by glycine, dried meat
Propylhomoserin, hydroxyproline composition, they provide intensity, elasticity for Dentin Structure holder, and provide condition for the mineralising of dentine.
Amino acid is one of the natural component of people's saliva, and substrate can be used as to participate in bacterial metabolism and produce ammonia process, improve mouth
The pH value of chamber environment is conducive to prevent dental caries.It is many to the research of amino acid at present, certain amino acid toothpaste in the market
It is only added to amino acid surfactant, concrete application of the amino acid in toothpaste is also seldom.
Invention content
It is an object of the invention to solve the problems, such as it is in the prior art exist, a kind of amino acid bio complex enzyme tooth is provided
Cream, the amino acid bio complex enzyme toothpaste form unique bacteriolyze antibacterial machine with biological complex enzyme, amino acid Synergistic antimicrobial
Reason, does not destroy its hetero-organization, does not generate drug resistance, effectively inhibits oral cavity harmful bacteria, reduces bacterium attachment, reduces plaque and refers to
Number, while erosion of the acid to tooth is resisted, be conducive to prevent dental caries, alleviate hemodia phenomenon, keep tooth firmer.
To achieve the above object, technical scheme of the present invention provides a kind of amino acid bio complex enzyme toothpaste, the ammonia
The composition of base acid biological complex enzyme toothpaste and the weight percent of component are：
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Amino acid 0.01-10%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus；
The sum of weight percent of each component is 100%；
The amino acid is positively charged amino acid and constitutes the amino acid composition of tooth component；The mass ratio of the two is 1:
0.1-10；
The enzyme preparation is muramidase and dextranase；The mass ratio of the two is 1:0.1-10.
Wherein, it is at least one of lysine, arginine, histidine that the amino acid, which is positively charged amino acid,.
Wherein, it is described constitute tooth component amino acid be proline, histidine, arginine, glycine, aspartic acid,
At least one of hydroxyproline.
The wherein described rubbing agent is at least one of hydrated silica, calcium monohydrogen phosphate, calcium carbonate.
The wherein described moisturizer is at least one of sorbierite, glycerine, propylene glycol, polyethylene glycol.
The wherein described surfactant is at least one of sodium lauroyl sarcosine, Cocoamidopropyl betaine.
The wherein described thickener is at least one of cellulose gum, Chondrus crispus, xanthans.
The wherein described acid-base buffer agent is tetrasodium pyrophosphate or tertiary sodium phosphate.
The wherein described taste-modifier is at least one of saccharin sodium, tri-chloro galactose type sugar, stevioside.
It is at least one of sodium phytate, zinc citrate, calcium pyrophosphate wherein to remove stain whitening agent.
The beneficial effects of the present invention are：On the basis of conventional toothpaste is formulated, addition biological complex enzyme, amino acid conduct
Main antimicrobial component, the poly- peptide sugar of muramidase selective dissolution bacteria cell wall, dextranase decompose tooth just facial disfigurement chain
The glucan that coccus generates, amino acid plays synergistic effect, common to inhibit oral cavity harmful bacteria, reduces bacterium attachment, reduces tooth bacterium
Spot index；Positively charged amino acid can be combined with the negative electrical charge group of dentin surface, and absorption calcium, phosphonium ion promote calcium, phosphorus
Ion deposition alleviates hemodia phenomenon in dentin surface and dentinal tubule；Partial amino-acid can be used as substrate, participate in
Bacterial metabolism produces ammonia process, improves the pH value of oral environment, resists erosion of the acid to tooth, is conducive to prevent dental caries；It mends
The amino acid for constituting tooth component is filled, collagen tissue can be promoted to synthesize, ensure the hardening of enamel, promoted its development, make tooth
Dental transition is firm.
Specific implementation mode
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate this hair
It is bright, rather than limit the scope of the invention.Under the premise of without departing substantially from technical solution of the invention, the present invention is made
Those of ordinary skill in the art's any change easy to implement fall within scope of the presently claimed invention.
With reference to embodiment, the specific embodiment of the present invention is further described.Once embodiment is only used for more
Add and clearly demonstrate technical scheme of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
The composition of amino acid bio complex enzyme toothpaste and the weight percent of component are in embodiment 1：
Hydrated silica 20%
Sorbierite 25%
Polyethylene glycol-400 15%
Sodium lauroyl sarcosine 2%
Cellulose gum 0.6%
Chondrus crispus 0.3%
Tertiary sodium phosphate 0.2%
Lysine 0.1%
Glycine 0.2%
Proline 0.2%
Muramidase 0.0002%
Dextranase 0.0002%
Tri-chloro galactose type sugar 0.1%
Zinc citrate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 2
The composition of amino acid bio complex enzyme toothpaste and the weight percent of component are in embodiment 2：
Hydrated silica 25%
Calcium carbonate 5%
Sorbierite 30%
Propylene glycol 10%
Cocoamidopropyl betaine 2%
Cellulose gum 0.6%
Xanthans 0.3%
Tertiary sodium phosphate 0.15%
Arginine 0.2%
Glycine 0.1%
Histidine 0.2%
Muramidase 0.0002%
Dextranase 0.0002%
Saccharin sodium 0.02%
Calcium pyrophosphate 0.1%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 3
The composition of amino acid bio complex enzyme toothpaste and the weight percent of component are in embodiment 3：
Hydrated silica 20%
Calcium monohydrogen phosphate 10%
Sorbierite 25%
Glycerine 10%
Sodium lauroyl sarcosine 1%
Cocoamidopropyl betaine 1%
Cellulose gum 0.5%
Chondrus crispus 0.3%
Tetrasodium pyrophosphate 0.5%
Histidine 0.2%
Aspartic acid 0.2%
Proline 0.1%
Muramidase 0.0002%
Dextranase 0.0002%
Stevioside 0.1%
Sodium phytate 0.3%
Aromatic 0.5%
Water surplus；
The sum of weight percent of each component is 100%.
Comparative example 1：
Comparative example 1 and embodiment 1 difference lies in：Without using lysine.
Comparative example 2：
Comparative example 2 and embodiment 1 difference lies in：Without using glycine and proline.
Comparative example 3：
Comparative example 3 and embodiment 1 difference lies in：Without using muramidase.
Comparative example 4：
Comparative example 4 and embodiment 1 difference lies in：Without using dextranase.
Use the amino acid bio complex enzyme toothpaste performance test methods prepared by the present invention for：
1, physical and chemical index and estimation of stability
Amino acid bio complex enzyme toothpaste in embodiment 1-3 and comparative example 1-4 is detected by GB/T 8372, as a result
For qualification, placed 30 ~ 45 days under the conditions of 45 DEG C, lotion does not spill over nozzle, does not isolate liquid, and fragrance color and luster is normal.
2, toothpaste is evaluated using degree
Choose 30 subjects（Without mouth disease）, with the lineal scale of 0-10 to toothpaste in embodiment 1-3 and comparative example 1-4
Viscosity, sand type, foam quality test and assess.
。
3, inhibit plaque and（Or）Mitigate gingivitis efficacy assessments
Choose 200 subjects（Without mouth disease）, subject is randomly divided into 5 groups, every group of each 40 people.Subject brushes daily
Tooth 2 times sooner or later, at least 2min, uses toothpaste 2cm, continues 6 months, using horizontal trembling method every time every time（Bass methods）It brushes teeth.
According to " plaque index（PLI）", " gingival sulcus bleeding index（SBI）", " gingival index（GI）" judged.
Criterion：
It is effective：Subjective symptom is obviously improved, plaque index（PLI）, gingival sulcus bleeding index（SBI）, gingival index（GI）Under being worth
Drop<1 or decline the 1/2 of its value.
It improves：Symptom mitigates, oulorrhagia improves, at least one decline in periodontal index.
In vain：Symptom slightly improves or unchanged.
Efficient=（Effective number/total case load）×100%
。
It can be seen that by the comparison of the experimental data of specific embodiment and comparative example, if addition amino acid and biological complex enzyme
On the physical and chemical index of lotion of toothpaste, stability, influence is had no using degree experience, but to reducing plaque, mitigation gingivitis, changing
Kind bleeding gums symptom has a significant impact.It is the key element in antimicrobial component, energy is used in combination with dextranase in muramidase
Reach good fungistatic effect, substantially reduce plaque, improves gum problem；The amino acid of addition can be negative with dentin surface
Charge groups, which combine or participate in bacterial metabolism as substrate, produces ammonia process, and synergistic effect is played with biological complex enzyme, common to inhibit
Oral cavity harmful bacteria, safeguards oral health.
Claims (10)
1. a kind of amino acid bio complex enzyme toothpaste, which is characterized in that the composition and group of the amino acid bio complex enzyme toothpaste
Point weight percent be：
Rubbing agent 20-40%
Moisturizer 15-30%
Surfactant 0.5-3%
Thickener 0.5-2%
Acid-base buffer agent 0.2-1%
Amino acid 0.01-10%
Enzyme preparation 0.0002-0.02%
Taste-modifier 0.01-0.5%
Except stain whitening agent 0.1-2%
Aromatic 0.5-2%
Water surplus；
The sum of weight percent of each component is 100%；
The amino acid is positively charged amino acid and constitutes the amino acid composition of tooth component；The mass ratio of the two is 1:
0.1-10；
The enzyme preparation is muramidase and dextranase；The mass ratio of the two is 1:0.1-10.
2. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the amino acid is positively charged
The amino acid of lotus is at least one of lysine, arginine, histidine.
3. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the composition tooth component
Amino acid is at least one of proline, histidine, arginine, glycine, aspartic acid, hydroxyproline.
4. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the rubbing agent is hydration silicon
At least one of stone, calcium monohydrogen phosphate, calcium carbonate.
5. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the moisturizer is sorb
At least one of alcohol, glycerine, propylene glycol, polyethylene glycol.
6. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the surfactant is the moon
At least one of osmanthus acylsarcosine sodium, Cocoamidopropyl betaine.
7. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the thickener is cellulose
At least one of glue, Chondrus crispus, xanthans.
8. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the acid-base buffer agent is coke
Tetrasodium phosphate or tertiary sodium phosphate.
9. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that the taste-modifier is sugar
At least one of smart sodium, tri-chloro galactose type sugar, stevioside.
10. according to the amino acid bio complex enzyme toothpaste described in claim 1, which is characterized in that described except stain whitening agent is
At least one of sodium phytate, zinc citrate, calcium pyrophosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810934440.2A CN108785119A (en) | 2018-08-16 | 2018-08-16 | A kind of amino acid bio complex enzyme toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810934440.2A CN108785119A (en) | 2018-08-16 | 2018-08-16 | A kind of amino acid bio complex enzyme toothpaste |
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| Publication Number | Publication Date |
|---|---|
| CN108785119A true CN108785119A (en) | 2018-11-13 |
Family
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| CN201810934440.2A Pending CN108785119A (en) | 2018-08-16 | 2018-08-16 | A kind of amino acid bio complex enzyme toothpaste |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478267A (en) * | 2019-09-27 | 2019-11-22 | 中合泰克(南京)生物科技有限公司 | A kind of efficient anti-caries children's toothpaste and preparation method thereof |
| CN111358725A (en) * | 2020-04-21 | 2020-07-03 | 斯耐奇(武汉)智能科技有限公司 | Toothpaste and preparation method thereof |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Biological enzyme oral cleaning and nursing toothpaste |
| CN111686035A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Bio-enzyme antibacterial anti-allergy toothpaste |
| CN112274478A (en) * | 2020-12-21 | 2021-01-29 | 广东微笑科技有限公司 | Gingiva protecting toothpaste containing arginine and preparation method thereof |
| CN112773727A (en) * | 2020-11-10 | 2021-05-11 | 江苏雪豹日化有限公司 | Preparation method of stain-removing and whitening biological lysozyme toothpaste composition |
| US11168287B2 (en) | 2016-05-26 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
| US12037497B2 (en) | 2016-01-28 | 2024-07-16 | Kimberly-Clark Worldwide, Inc. | Anti-adherent composition against DNA viruses and method of inhibiting the adherence of DNA viruses to a surface |
| EP4268828A4 (en) * | 2020-12-28 | 2024-11-13 | Sunstar Suisse SA | COMPOSITION FOR THE ORAL CAVITY |
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| CN101721324A (en) * | 2010-01-14 | 2010-06-09 | 江苏雪豹日化有限公司 | Biological complex enzyme toothpaste and preparation method thereof |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
| CN106109382A (en) * | 2016-07-31 | 2016-11-16 | 申秋英 | Aminoacid toothpaste preparation method |
| CN108078802A (en) * | 2018-01-24 | 2018-05-29 | 深圳市芭格美生物科技有限公司 | A kind of toothpaste and preparation method thereof |
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| CN101721324A (en) * | 2010-01-14 | 2010-06-09 | 江苏雪豹日化有限公司 | Biological complex enzyme toothpaste and preparation method thereof |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12037497B2 (en) | 2016-01-28 | 2024-07-16 | Kimberly-Clark Worldwide, Inc. | Anti-adherent composition against DNA viruses and method of inhibiting the adherence of DNA viruses to a surface |
| US11168287B2 (en) | 2016-05-26 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface |
| CN110478267A (en) * | 2019-09-27 | 2019-11-22 | 中合泰克(南京)生物科技有限公司 | A kind of efficient anti-caries children's toothpaste and preparation method thereof |
| CN111358725A (en) * | 2020-04-21 | 2020-07-03 | 斯耐奇(武汉)智能科技有限公司 | Toothpaste and preparation method thereof |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Biological enzyme oral cleaning and nursing toothpaste |
| CN111686035A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Bio-enzyme antibacterial anti-allergy toothpaste |
| CN112773727A (en) * | 2020-11-10 | 2021-05-11 | 江苏雪豹日化有限公司 | Preparation method of stain-removing and whitening biological lysozyme toothpaste composition |
| CN112773727B (en) * | 2020-11-10 | 2023-08-11 | 江苏雪豹日化有限公司 | Preparation method of a stain-removing and whitening biological lysozyme toothpaste composition |
| CN112274478A (en) * | 2020-12-21 | 2021-01-29 | 广东微笑科技有限公司 | Gingiva protecting toothpaste containing arginine and preparation method thereof |
| EP4268828A4 (en) * | 2020-12-28 | 2024-11-13 | Sunstar Suisse SA | COMPOSITION FOR THE ORAL CAVITY |
| CN113813197A (en) * | 2021-10-29 | 2021-12-21 | 重庆登康口腔护理用品股份有限公司 | Composition for improving antibacterial activity and application thereof in oral products |
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Application publication date: 20181113 |
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| RJ01 | Rejection of invention patent application after publication |