CN108783103A - A kind of aquatic products pharmaceutical chemistry mixing method - Google Patents
A kind of aquatic products pharmaceutical chemistry mixing method Download PDFInfo
- Publication number
- CN108783103A CN108783103A CN201810645125.8A CN201810645125A CN108783103A CN 108783103 A CN108783103 A CN 108783103A CN 201810645125 A CN201810645125 A CN 201810645125A CN 108783103 A CN108783103 A CN 108783103A
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- Prior art keywords
- pharmaceutical chemistry
- feed
- aquatic products
- drug
- mixing method
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The invention discloses a kind of aquatic products pharmaceutical chemistry mixing methods to be uniformly sprayed in feed and be dried after mixing well by the way that drug to be placed in ethanol solution after dispersion, egg white is added in the feed of mixing, it stirs evenly and dries, sprinkling ethyl alcohol dries, and 4 DEG C save backup completion.The method of the present invention can effectively increase adhesiveness of the pharmaceutical chemistry in water body, and compared with prior art, pharmaceutical chemistry is more stable in water body, effectively saves drug effect, reduce the waste of drug, reduce or remit pollution of the drug to water body.
Description
Technical field
The invention belongs to technical field of aquaculture, are related to Medicines in Aquaculture the relevant technologies, and specially a kind of aquatic products pharmaceutical chemistry is mixed
Method processed.
Background technology
It is usually needed in aquatic animal disease therapeutic process using commercial feed as carrier, medicament-carried realization oral medication.
However, due to the particularity of aquatic livestock local environment, it is desirable that pharmaceutical chemistry has stronger stability and drug in feed surface
Stronger adsorption capacity (being not easy to fall off and dissolve out from feed surface).Therefore it needs to add centainly during pharmaceutical chemistry mixing
Adhesive.
The prior art is usually used using flour as adhesive, but using flour as adhesive, bonding effect, water
Stability and adsorption ability are poor, it cannot be guaranteed that added drug can smoothly enter into fish body.Cause disease treatment means not
It can smoothly implement, disease treatment is caused to fail.
Invention content
It is an object of the present invention to overcome the above deficiencies, to provide a kind of effective pharmaceutical chemistry mixing method, utilizes
Egg white and ethyl alcohol mixing pharmaceutical chemistry, it is simple to operation, stability of the pharmaceutical chemistry in water body can be increased substantially.
In order to reach the above technical purpose, the present invention is realized especially by following technical scheme：
A kind of aquatic products pharmaceutical chemistry mixing method, specifically includes following steps：
1) drug is placed in ethanol solution after disperseing, is uniformly sprayed in feed and mixes well, dries；
2) egg white is added in the feed of mixing, stirs evenly and dries；
3) after sprinkling ethyl alcohol dries, 4 DEG C save backup.
Further, in step (1) usage amount of feed and ethyl alcohol according to mass volume ratio be 5g/mL.
Further, feed and the additive amount of egg white according to mass volume ratio are 10g/mL in step (2).
Further, in step (3) ethyl alcohol fountain height according to the mass volume ratio of feed and ethyl alcohol be 10g/mL.
Concentration of alcohol of the present invention is 100%, and the egg white needs to be sufficiently stirred before mixing.
Beneficial effects of the present invention are：
The present invention does not add water substantially during mixing pharmaceutical chemistry, avoids feed and is raised caused by due to absorbing water excessively
Expect disintegration (can not be molded) and loosely organized (reduction feed stability) in water；The use of egg white makes to be adsorbed with drug
Feed surface form one layer of protein film, drug falling off from feed surface after slowing down to a certain extent into water environment
And the diffusion velocity to water body；Finally by protein denaturation caused by alcohol, the film hydrophily on pharmaceutical chemistry surface is made to decline
(reducing pharmaceutical chemistry to be interfered by water environment), structure more closely, further increase stability of the pharmaceutical chemistry in water body.
Description of the drawings
Fig. 1 (1) is 1 pharmaceutical chemistry grain size of the embodiment of the present invention and appearance comparison diagram；
Fig. 1 (2) is that 1 pharmaceutical chemistry of the embodiment of the present invention enters 10 seconds comparison diagrams of water；
Fig. 1 (3) is that 1 pharmaceutical chemistry of the embodiment of the present invention enters 120 seconds comparison diagrams of water；
2 pharmaceutical chemistry grain size of Fig. 2 (1) embodiment of the present invention and appearance comparison diagram；
Fig. 2 (2) is that 2 pharmaceutical chemistry of the embodiment of the present invention enters 10 seconds comparison diagrams of water；
Fig. 2 (3) is that 2 pharmaceutical chemistry of the embodiment of the present invention enters 120 seconds comparison diagrams of water；
Fig. 3 (1) is 3 pharmaceutical chemistry grain size of the embodiment of the present invention and appearance comparison diagram；
Fig. 3 (2) is that 3 pharmaceutical chemistry bait of the embodiment of the present invention enters 10 seconds comparison diagrams of water；
Fig. 3 (3) is that 3 pharmaceutical chemistry of the embodiment of the present invention enters 120 seconds comparison diagrams of water.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with the embodiment of the present invention, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the implementation in the present invention
Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to
The scope of protection of the invention.
It is usually needed in aquatic animal disease therapeutic process at present using commercial feed as carrier, medicament-carried realize takes orally
Medication.However, due to the particularity of aquatic livestock local environment, it is desirable that there is pharmaceutical chemistry stronger stability and drug to raise
Expect the stronger adsorption capacity in surface (being not easy to fall off and dissolve out from feed surface).Therefore it needs to add during pharmaceutical chemistry mixing
Certain adhesive.In laboratory work, find using flour as adhesive, bonding effect, water stability and surface
Adsorption capacity is poor, it cannot be guaranteed that added drug can smoothly enter into fish body, causes disease treatment means that cannot smoothly implement, leads
Cause disease treatment failure.The present invention can overcome above-mentioned shortcoming, be a kind of effective pharmaceutical chemistry mixing method, easy using raw material
, preparation is simple, is entirely capable of meeting the needs of in laboratory prepared by aquatic livestock pharmaceutical chemistry.
Technical scheme of the present invention is completed especially by following steps：
1) drug loads：Drug is diluted with ethyl alcohol and is disperseed, is uniformly sprayed on ethyl alcohol in the ratio of 50g/10mL ethyl alcohol
It mixes well, dries in feed；
2) plated film：Egg white is added in the ratio of 10g/mL, mixes well, dries；
3) film hardens：The ratio of 10g/mL sprays ethyl alcohol, dries, 4 DEG C save backup.
The concentration of alcohol wherein used is 100%, and egg white need to be sufficiently stirred.
Further effect displaying and explanation are done to technical solution of the present invention below by concrete case, wherein：
Handle A：Water+medicine+feed
Handle B：Water+flour+medicine+feed
Handle C：The method of the present invention
Embodiment 1
Application of the method for the present invention in the preparation of water soluble drug (astragalus polyose) pharmaceutical chemistry, prepares in astragalus polyose pharmaceutical chemistry
When, carry out mixing processing using three kinds of schemes：Handle A, water+medicine+feed；Handle B, water+flour+medicine+feed；C is handled, this
Inventive method.After pharmaceutical chemistry is successfully prepared, stability test is carried out, the 10s after pharmaceutical chemistry enters water and 120s observe and record medicine respectively
The form and surface drug of bait adhere to situation.
Experimental result is as shown in Figure 1, compared with the control group, astragalus polyose spice shows grain size in different disposal
Increase, increase degree highest is handled with C；Two kinds of processing feed colors of A, B are partially deep, and when drying in the shade, surface tack, stickiness is with B
The most notable, the easy adhesion of feed is handled, C processing is without notable stickiness；And stability test result is shown in water：Enter water
When 10s, A processing surface has granular substance to fall off, and B processing can also be observed that particle falls off, and have yellowish color substance to dissolve out
Phenomenon, C processing are not observed that particle falls off and are dissolved out with substance；When entering water 120s, A processing and B handle different degrees of pharmaceutical chemistry and collapse
It dissipates, the visible phenomenon of bursting apart of C processing, but the visible canescence film sample substance of feed surface, it is adhered in the protection of this film sample substance
Under, although bursting apart from inside to outside occurs in pharmaceutical chemistry, surface does not occur disintegration and the case where particle falls off, and example shows this
Inventive method prepares pharmaceutical chemistry best results.
Embodiment 2
Application of the method for the present invention in the preparation of insoluble drug (Enrofloxacin) pharmaceutical chemistry, prepares in Enrofloxacin pharmaceutical chemistry
When, carry out mixing processing using three kinds of schemes：Handle A, water+medicine+feed；Handle B, water+flour+medicine+feed；C is handled, this
Inventive method.After pharmaceutical chemistry is successfully prepared, stability test is carried out, the 10s after pharmaceutical chemistry enters water and 120s observe and record medicine respectively
The form and surface drug of bait adhere to situation.
Experimental result is as shown in Fig. 2, compared with the control group, Enrofloxacin spice equal table in different spice processing modes
Reveal the increase to grain size, but C processing increase degrees are handled less than other two kinds；For feed surface situation, two kinds of A, B
Processing feed granules surface, which has, slightly bursts apart, scaling-off phenomenon, and C handles surface relative smooth, does not observe and bursts apart, is scaling-off
The phenomenon that；And stability test result is shown in water：When entering water 10s, there is granular substance obscission on A, B processing surface,
C processing does not observe that particle falls off；When entering water 120s, A processing and B handle different degrees of pharmaceutical chemistry disintegration, and C processing is visible to burst apart
Phenomenon, the visible canescence film sample substance of feed surface, under the protection of this film sample substance is adhered, although pharmaceutical chemistry occurs
Bursting apart from inside to outside, but surface does not occur disintegration and the case where particle falls off, example shows that the method for the present invention prepares pharmaceutical chemistry
Best results.
Embodiment 3
Application of the present invention in the preparation of alcohol-soluble drug (curcumin) pharmaceutical chemistry, when prepared by curcumin pharmaceutical chemistry, using three
Kind scheme carries out mixing processing：Handle A, water+medicine+feed；Handle B, water+flour+medicine+feed；Handle C, the method for the present invention.
After pharmaceutical chemistry is successfully prepared, stability test is carried out, the 10s after pharmaceutical chemistry enters water and 120s observes and records the form of pharmaceutical chemistry respectively
And surface drug adheres to situation.
Experimental result is as shown in figure 3, compared with the control group, curcumin spice shows feed in different disposal group
The phenomenon that grain size increases, three kinds of processing are similar to the change situation of grain size；For feed granules surface, in three kinds of processing
Apparent phenomenon of bursting apart is observed, but does not occur particle obscission in C processing groups, is observed in other two kinds processing
Particle obscission.And stability test result is shown in water：When entering water 10s, there is granular substance on A, B processing surface
Obscission, C processing do not observe that particle falls off；When entering water 120s, A processing and B handle different degrees of pharmaceutical chemistry disintegration, C processing
It can be seen that phenomenon of bursting apart, but the visible canescence film sample substance of feed surface, under the protection of this film sample substance is adhered, pharmaceutical chemistry
Although there is disintegration from inside to outside, surface does not still occur disintegration under being adhered of film sample substance and particle falls off
Situation, example show that the method for the present invention prepares pharmaceutical chemistry best results.
Claims (6)
1. a kind of aquatic products pharmaceutical chemistry mixing method, which is characterized in that include the following steps：
1) drug is placed in ethanol solution after disperseing, is uniformly sprayed in feed and mixes well, dries；
2) egg white is added in the feed of mixing, stirs evenly and dries；
3) after sprinkling ethyl alcohol dries, 4 DEG C save backup.
2. a kind of aquatic products pharmaceutical chemistry mixing method according to claim 1, which is characterized in that feed and ethyl alcohol in step (1)
Usage amount according to mass volume ratio be 5g/mL.
3. a kind of aquatic products pharmaceutical chemistry mixing method according to claim 1, which is characterized in that feed and egg in step (2)
Clear additive amount is 10g/mL according to mass volume ratio.
4. a kind of aquatic products pharmaceutical chemistry mixing method according to claim 1, which is characterized in that the sprinkling of ethyl alcohol in step (3)
Amount is 10g/mL according to the mass volume ratio of feed and ethyl alcohol.
5. a kind of aquatic products pharmaceutical chemistry mixing method according to claim 1, which is characterized in that the concentration of alcohol is
100%.
6. a kind of aquatic products pharmaceutical chemistry mixing method according to claim 1, which is characterized in that the egg white is before mixing
It needs to be sufficiently stirred.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810645125.8A CN108783103A (en) | 2018-06-21 | 2018-06-21 | A kind of aquatic products pharmaceutical chemistry mixing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810645125.8A CN108783103A (en) | 2018-06-21 | 2018-06-21 | A kind of aquatic products pharmaceutical chemistry mixing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108783103A true CN108783103A (en) | 2018-11-13 |
Family
ID=64084202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810645125.8A Pending CN108783103A (en) | 2018-06-21 | 2018-06-21 | A kind of aquatic products pharmaceutical chemistry mixing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108783103A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102952A (en) * | 1993-11-20 | 1995-05-31 | 中国科学院化工冶金研究所 | Bait material with covered film |
| CN106721661A (en) * | 2016-12-28 | 2017-05-31 | 江苏天石生物科技有限公司 | A kind of method of aquatic granulated feed quick-binding medicine and additive |
| WO2018056898A1 (en) * | 2016-09-23 | 2018-03-29 | Pearl Aqua Co., Ltd. | Aquaculture feed and method of producing same |
-
2018
- 2018-06-21 CN CN201810645125.8A patent/CN108783103A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102952A (en) * | 1993-11-20 | 1995-05-31 | 中国科学院化工冶金研究所 | Bait material with covered film |
| WO2018056898A1 (en) * | 2016-09-23 | 2018-03-29 | Pearl Aqua Co., Ltd. | Aquaculture feed and method of producing same |
| CN106721661A (en) * | 2016-12-28 | 2017-05-31 | 江苏天石生物科技有限公司 | A kind of method of aquatic granulated feed quick-binding medicine and additive |
Non-Patent Citations (1)
| Title |
|---|
| 姜慧君 等: "《医用化学》", 30 June 2017, 东南大学出版社 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181113 |
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| RJ01 | Rejection of invention patent application after publication |