CN108771684A - The application of the composition of acetylamino evericin and praziquantel, medicine for parasitic disease and preparation method thereof - Google Patents
The application of the composition of acetylamino evericin and praziquantel, medicine for parasitic disease and preparation method thereof Download PDFInfo
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- CN108771684A CN108771684A CN201810709665.8A CN201810709665A CN108771684A CN 108771684 A CN108771684 A CN 108771684A CN 201810709665 A CN201810709665 A CN 201810709665A CN 108771684 A CN108771684 A CN 108771684A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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Abstract
The application that the invention discloses the compositions of acetylamino evericin and praziquantel in medicine for parasitic disease, medicine for parasitic disease and preparation method thereof.The medicine for parasitic disease, including acetylamino evericin and praziquantel；It further include further Thymol；The preparation method of the medicine for parasitic disease is：Acetylamino evericin and praziquantel are added in auxiliary agent one by one, adds next component again after previous component stirring and dissolving, after the completion of dissolving, obtains medicine for parasitic disease；When there is Thymol in drug, Thymol and acetylamino evericin and praziquantel are added in auxiliary agent one by one.Medicine for parasitic disease of the present invention, to acarid, parasite have it is good kill except effect, be not likely to produce drug resistance, safe.
Description
Technical field
The present invention relates to technical field of veterinary, and in particular to the composition of acetylamino evericin and praziquantel
Using, medicine for parasitic disease and preparation method thereof.
Background technology
Parasitic disease is that animal husbandry is very common, endangers extremely serious disease.Parasite captures the nutrients needed for domestic animal,
And harmful substance is drained and secretes, cause domestic animal to become thin, is weak, anaemia, or even is dead, influencing the production performance and product of domestic animal
Matter causes great economic loss to animal husbandry.
Current anti parasitic disease medicine, drug effect slowly effect, anti-insect activity is relatively low, and easy tos produce drug resistance.
Invention content
Based on this, it is necessary to provide the compositions of a kind of acetylamino evericin and praziquantel in anti parasitic by the present invention
Application in medicine, obtained drug can be improved immune response level, alleviate pathological state caused by parasitic infection,
Anti-insect activity is higher, can maintain the health status and production performance of body.
The present invention, which there is a need to, provides a kind of medicine for parasitic disease.
The present invention, which there is a need to, provides a kind of preparation method of medicine for parasitic disease.
In order to achieve the object of the present invention, the present invention uses following technical scheme：
A kind of application of the composition of acetylamino evericin and praziquantel in medicine for parasitic disease.
Above-mentioned medicine for parasitic disease compounds acetylamino evericin and praziquantel together, the two person's collaboration
Effect, maximally plays pest-resistant performance, through experiment, is used for animal body, and the immune response that body can be improved is horizontal, alleviates parasitic
Pathological state caused by insect infection, anti-insect activity is higher, can maintain the health status and production performance of body.
In some of embodiments, the mass ratio of the acetylamino evericin and the praziquantel is 1:(0.1-
5)。
In some of embodiments, the composition further includes Thymol.Thymol is added, the composition can be improved
Insecticidal effect, and reduce the stress reaction of animal body.
In some of embodiments, the mass ratio of the acetylamino evericin and the Thymol is 1:
(0.01-5)。
In some of embodiments, the mass ratio of the acetylamino evericin and the Thymol is 1:2, institute
The mass ratio for stating acetylamino evericin and the praziquantel is 1:2.
The present invention also provides a kind of medicines for parasitic disease, including acetylamino evericin and praziquantel.
In some of embodiments, the mass ratio of the acetylamino evericin and the praziquantel is 1:(0.1-
5)。
In some of embodiments, the medicine for parasitic disease includes the component of following parts by weight：Acetylamino Ah
Tie up rhzomorph 0.1%-10%, praziquantel 0.1%-10% and auxiliary material surplus.
In some of embodiments, the medicine for parasitic disease further includes Thymol.
In some of embodiments, the mass ratio of the acetylamino evericin and the Thymol is 1:
(0.01-5)。
In some of embodiments, the medicine for parasitic disease includes the component of following parts by weight：Thymol
0.01%-5%, acetylamino evericin 0.1%-10%, praziquantel 0.1%-10% and auxiliary material surplus.
In some of embodiments, the medicine for parasitic disease be tablet, granule, pulvis, oral agents, injection or
Dashing agent.
The present invention also provides a kind of methods preparing the medicine for parasitic disease, which is characterized in that by acetylamino
Avermectin and praziquantel are added in auxiliary material one by one, obtain medicine for parasitic disease；When there is Thymol in drug, by hundred li
Fragrant phenol is added in auxiliary material one by one with acetylamino evericin and praziquantel.
Specific implementation mode
It to facilitate the understanding of the present invention, below will be to invention is more fully described.But the present invention can be to be permitted
Mostly different form is realized, however it is not limited to embodiment described herein.Make on the contrary, purpose of providing these embodiments is
It is more thorough and comprehensive to the understanding of the disclosure.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to description tool in the description of the invention herein
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The present invention provides a kind of composition answering in medicine for parasitic disease of acetylamino evericin and praziquantel
With.
Wherein, the mass ratio of acetylamino evericin and praziquantel is 1:(0.1-5).The group that select the propriation obtains
It is preferable to close object drug effect.
Combinations of the above object further includes Thymol, Thymol is added, the insecticidal effect of the composition can be improved, and subtract
The stress reaction of petty action object.
The mass ratio of acetylamino evericin therein and the Thymol is 1:(0.01-5).
Preferably, the mass ratio of acetylamino evericin and the Thymol is 1:2, the acetylamino AVM hereinafter
The mass ratio of rhzomorph and the praziquantel is 1:2.
The present invention also provides a kind of medicines for parasitic disease, including acetylamino evericin and praziquantel.
Wherein, the mass ratio of acetylamino evericin and praziquantel is 1:(0.1-5).The group that select the propriation obtains
It is preferable to close object drug effect.
Example medicine for parasitic disease as mentioned, includes the component of following parts by weight：Acetylamino evericin 0.1%-
10%, praziquantel 0.1%-10% and auxiliary material surplus.
Above-mentioned medicine for parasitic disease further includes Thymol.The drug effect of the composition is more preferable after addition Thymol,
And stress reaction of the animal to drug can be reduced.
Wherein, the mass ratio of acetylamino evericin and Thymol is 1:(0.01-5).
For example, above-mentioned medicine for parasitic disease, includes the component of following parts by weight：Thymol 0.01%-5%, second
Acylamino- avermectin 0.1%-10%, praziquantel 0.1%-10% and auxiliary material surplus.
Preferably, the mass ratio of acetylamino evericin and Thymol is 1:2, acetylamino evericin and pyrrole
The mass ratio of quinoline ketone is 1:2.
Such as Thymol 0.01%, 0.05%, 0.1%, 0.4%, 0.8%, 1%, 2%, 3%, 3.5%, 4%,
4.5% and 5%；Acetylamino evericin 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% and
10%；Praziquantel 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% and 10%.
Auxiliary material is one kind or several in pharmaceutically acceptable auxiliary material, including solvent, transdermal agent, cosolvent and antioxidant
Kind.Certainly above-mentioned auxiliary material can also include the acceptable auxiliary material of other drugs, such as preservative etc..
The medicine for parasitic disease can make piece agent, granule, pulvis, oral agents, injection (including long-acting injection
Liquid), dashing agent etc., when being fabricated to different dosage forms, select corresponding auxiliary material.
Such as when being fabricated to dashing agent, above-mentioned medicine for parasitic disease includes the component of following parts by weight：Thymol
0.01%-5%, acetylamino evericin 0.1%-10%, praziquantel 0.1%-10%, transdermal agent 1%-50% and solvent
Surplus.Such as transdermal agent 1%, 5%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45% and 50%.May be used also
To include antioxidant.The content of antioxidant be 0.005%-5%, such as antioxidant 0.005%, 0.01%, 0.02%,
0.1%, 0.5%, 1%, 3% and 5%.
Antioxidant is one in tocopherol, butylated hydroxy anisole, dibutyl hydroxy toluene and tert-butyl hydroquinone
Kind is several.Antioxidant is preferably dibutyl hydroxy toluene, dibutyl hydroxy toluene can preferably with Thymol, acetyl ammonia
Base avermectin and praziquantel three cooperation, resistance drug, which is placed in for a long time in air, to be aoxidized, its drug effect is increased.
Solvent is ethyl alcohol, propylene glycol, isopropanol, dimethylformamide, vegetable oil, glycerine, atoleine and ethyl oleate
And one or more of water.Solvent is preferably ethyl alcohol and/or propylene glycol, and the two can preferably dissolve Thymol, acetyl ammonia
Base avermectin and praziquantel.
The content of transdermal agent is 1%-50%.Transdermal agent is isopropyl myristate, dimethyl sulfoxide (DMSO), decyl methyl sulfoxide
And one or more of lauric acid Azone.Transdermal agent is preferably lauric acid Azone, and lauric acid Azone can be with thyme
Phenol preferably coordinates, and discharges its drug effect to the maximum extent, and promoting the main ingredient in pharmaceutical preparation, faster or more ground penetrates in skin
Or enter the circulatory system through skin, to play locally or systemically therapeutic effect.
When above-mentioned medicine for parasitic disease is oral solution or injection, auxiliary material includes solvent, and solvent is ethyl alcohol, the third two
Alcohol, isopropanol, dimethylformamide, vegetable oil, glycerine, atoleine and one or more of ethyl oleate and water.
When above-mentioned medicine for parasitic disease is tablet, auxiliary material include diluent, adhesive, disintegrant, glidant,
Lubricant.Diluent is lactose, microcrystalline cellulose, mannitol, superfine silica gel powder, sorbierite, compressible sucrose, starch and maltose
One or more of.Adhesive is one in starch, pregelatinized starch, povidone, carbomer and hydroxypropyl methyl cellulose
Kind is several.Disintegrant is sodium carboxymethyl starch, crospovidone, low-substituted hydroxypropyl methylcellulose, sodium alginate, carboxymethyl fibre
Dimension plain one or more of sodium and croscarmellose sodium.Glidant be calcium silicates, colloidal silicon dioxide, talcum powder,
One or more of magnesia and magnesium silicate.Lubricant is magnesium stearate, lauryl sodium sulfate, stearic acid, stearate
And one or more of hydrogenated vegetable oil.
When above-mentioned medicine for parasitic disease is pulvis, auxiliary material includes diluent, disintegrant.Diluent be lactose,
One or more of microcrystalline cellulose, mannitol, superfine silica gel powder, sorbierite, compressible sucrose, starch and maltose.Disintegration
Agent is sodium carboxymethyl starch, crospovidone, low-substituted hydroxypropyl methylcellulose, sodium alginate, sodium carboxymethylcellulose and crosslinking
One or more of sodium carboxymethylcellulose.
When above-mentioned medicine for parasitic disease is granule, auxiliary material includes diluent, adhesive, disintegrant.Dilution
Agent be lactose, microcrystalline cellulose, mannitol, superfine silica gel powder, sorbierite, compressible sucrose, starch and maltose in one kind or
It is several.Adhesive is one kind or several in starch slurry, pregelatinized starch, povidone, carbomer and hydroxypropyl methyl cellulose
Kind.Disintegrant is sodium carboxymethyl starch, crospovidone, low-substituted hydroxypropyl methylcellulose, sodium alginate, sodium carboxymethylcellulose
And one or more of croscarmellose sodium.
Used supplementary material legal can on the market obtain in above-mentioned medicine for parasitic disease, be easy to buy.
The preparation method of above-mentioned medicine for parasitic disease is：Acetylamino evericin and praziquantel are added one by one auxiliary
In material, adds next component again after previous component stirring and dissolving, after the completion of dissolving, obtain medicine for parasitic disease；When in drug
When having Thymol, Thymol and acetylamino evericin and praziquantel are added in auxiliary material one by one.
For example, prepare in dashing agent when, by Thymol, acetylamino evericin and praziquantel, solvent, transdermal agent and
Antioxidant is added in solvent one by one, adds next component again after previous component stirring and dissolving, and all after the completion of dissolving, phase is made
The dosage form answered, obtains medicine for parasitic disease.
When solvent is several, first solvent agent is mixed, adds said components.
Prepare in tablet when, by Thymol, acetylamino evericin and praziquantel, disintegrant, diluent according to etc.
Measure incremental method mixing；It adds adhesive to be uniformly mixed, softwood, quickly granulation processed obtain wet granular；Wet granular is dried, is added
Glidant and mix lubricant are uniform, tabletting to get.
Prepare in pulvis when, by Thymol, acetylamino evericin and praziquantel, disintegrant, diluent according to etc.
Measure incremental method mixing to get.
Prepare in granule when, by Thymol, acetylamino evericin and praziquantel, disintegrant, diluent according to
Equal increments method mixing；Add adhesive to be uniformly mixed, softwood processed, quickly granulation, obtain wet granular, whole grain to get.
When preparing in oral solution and injection, Thymol, acetylamino evericin and praziquantel are added to solvent
In, be continuously stirring to, add balance solvent constant volume, under the protection of nitrogen, filtration sterilization to get.
Above-mentioned medicine for parasitic disease, together by Thymol, acetylamino evericin and praziquantel compounding, three
Person acts synergistically, and maximally plays pest-resistant performance, through experiment, is used for animal body, and the immune response that body can be improved is horizontal, delays
Pathological state caused by solving parasitic infection, anti-insect activity is higher, can maintain the health status and production performance of body.
The embodiment that will be further illustrated the present invention below by several embodiments：
Embodiment one
The present embodiment provides a kind of medicines for parasitic disease, are dashing agent, are grouped as by the group of following parts by weight：Thyme
Phenol 1%, acetylamino evericin 0.5%, praziquantel 1%, dibutyl hydroxy toluene 0.02%, lauric acid Azone 5%, second
Alcohol 10% and propylene glycol surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and mixed with propylene glycol are become into solvent, then by hundred
In fragrant phenol, acetylamino evericin, praziquantel, dibutyl hydroxy toluene and lauric acid Azone sequentially add in solvent, wait for
Add next component after previous component stirring and dissolving again, after stirring and dissolving is complete, obtains above-mentioned medicine for parasitic disease.
Embodiment two
The present embodiment provides a kind of medicines for parasitic disease, are dashing agent, are grouped as by the group of following parts by weight：Thyme
Phenol 2%, acetylamino evericin 1%, praziquantel 2%, dimethyl sulfoxide (DMSO) 5%, lauric acid Azone 5%, butylhydroxy fennel
Fragrant ether 0.5% and ethanol balance.
The preparation method of above-mentioned medicine for parasitic disease is：By Thymol, acetylamino evericin, praziquantel,
Dimethyl sulfoxide (DMSO), lauric acid Azone and butylated hydroxy anisole sequentially add in ethyl alcohol, after previous component stirring and dissolving again
Add next component, after stirring and dissolving is complete, obtains above-mentioned medicine for parasitic disease.
Embodiment three
The present embodiment provides a kind of medicines for parasitic disease, are dashing agent, are grouped as by the group of following parts by weight：Thyme
Phenol 5%, acetylamino evericin 1%, praziquantel 5%, isopropyl myristate 10%, lauric acid Azone 20%, isopropyl
Alcohol 20% and ethanol balance.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and isopropanol are mixed into solvent, then by hundred
In fragrant phenol, acetylamino evericin, praziquantel, isopropyl myristate and lauric acid Azone sequentially add in solvent, wait for
Add next component after previous component stirring and dissolving again, after stirring and dissolving is complete, obtains above-mentioned medicine for parasitic disease.
Example IV
The present embodiment provides a kind of medicines for parasitic disease, are dashing agent, are grouped as by the group of following parts by weight：Acetyl ammonia
Base avermectin 0.5%, praziquantel 1%, dibutyl hydroxy toluene 0.02%, lauric acid Azone 5%, ethyl alcohol 10% and the third two
Alcohol surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and mixed with propylene glycol are become into solvent, then by second
Acylamino- avermectin, praziquantel, lauric acid Azone, dimethyl sulfoxide (DMSO), butylated hydroxy anisole and tocopherol sequentially add
In solvent, adds next component again after previous component stirring and dissolving, after stirring and dissolving is complete, obtain above-mentioned anti parasitic disease medicine
Object.
Embodiment five
The present embodiment provides a kind of medicines for parasitic disease, are injection, are grouped as by the group of following parts by weight：Thyme
Phenol 5%, acetylamino evericin 10%, praziquantel 10%, propylene glycol 40%, ethyl alcohol 10%, water for injection surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Water for injection 40ml is taken, under constant stirring, at addition
Propylene glycol and ethyl alcohol is then added in Thymol, acetylamino evericin, the praziquantel just measured, and continuously stirs until becoming
Aqueous solution adds surplus water for injection constant volume, and under the protection of nitrogen, filtration sterilization, embedding to obtain the final product.
Embodiment six
The present embodiment provides a kind of medicines for parasitic disease, are tablet, are grouped as by the group of following parts by weight：Thymol
2%, acetylamino evericin 0.1%, praziquantel 1%, lactose 40%, povidone 1.5%, crospovidone 6%, colloid two
Silica 0.5%, magnesium stearate 0.5% and microcrystalline cellulose surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Solid material is crossed into 80 mesh sieve, it is spare；Claim according to recipe quantity
Material is taken, by Thymol, acetylamino evericin, praziquantel, crospovidone, lactose and microcrystalline cellulose according to equivalent
Incremental method mixing；Then povidone is added to be uniformly mixed, softwood, quickly granulation processed obtain wet granular；By wet granular at 50 DEG C -60
Moisture DEG C is dried in 2%-3.5%, crosses 20 mesh sieves；Colloidal silicon dioxide is added and magnesium stearate is uniformly mixed, examines
After qualification, tabletting to get.
Embodiment seven
The present embodiment provides a kind of medicines for parasitic disease, are granule, are grouped as by the group of following parts by weight：Thyme
Phenol 2%, acetylamino evericin 0.1%, praziquantel 1%, lactose 40%, povidone 1.5%, crospovidone 6% and micro-
Crystalline cellulose surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Solid material is crossed into 80 mesh sieve, it is spare；Claim according to recipe quantity
Material is taken, by Thymol, acetylamino evericin, praziquantel, crospovidone, lactose and microcrystalline cellulose according to equivalent
Incremental method mixing；Then povidone is added to be uniformly mixed, softwood, quickly granulation processed obtain wet granular, cross 20 mesh sieves, examine
After qualification to get.
Embodiment eight
The present embodiment provides a kind of medicines for parasitic disease, are pulvis, are grouped as by the group of following parts by weight：Thymol
2%, acetylamino evericin 0.1%, praziquantel 1%, lactose 40% and microcrystalline cellulose surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Solid material is crossed into 80 mesh sieve, it is spare；Claim according to recipe quantity
Material is taken, by Thymol, acetylamino evericin, praziquantel, lactose and microcrystalline cellulose according to equal increments method mixing,
After the assay was approved to get.
Embodiment nine
The present embodiment provides a kind of medicines for parasitic disease, are oral solution, are grouped as by the group of following parts by weight：Thyme
Phenol 5%, acetylamino evericin 10%, praziquantel 10%, propylene glycol 20%, ethyl alcohol 10%, water for injection surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Water for injection 40ml is taken, under constant stirring, at addition
Propylene glycol and ethyl alcohol is then added in Thymol, acetylamino evericin, the praziquantel just measured, and continuously stirs until becoming
Aqueous solution adds surplus water for injection constant volume, and embedding to obtain the final product.
Comparative example one
The comparative example provides a kind of medicine for parasitic disease, is grouped as by the group of following parts by weight：Thymol 1%, second
More than acylamino- avermectin 0.5%, dibutyl hydroxy toluene 0.02%, lauric acid Azone 5%, ethyl alcohol 10% and propylene glycol
Amount.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and mixed with propylene glycol are become into solvent, then by hundred
In fragrant phenol, acetylamino evericin, dibutyl hydroxy toluene and lauric acid Azone sequentially add in solvent, wait for previous component
Add next component after stirring and dissolving again, after stirring and dissolving is complete, obtains above-mentioned medicine for parasitic disease.
Comparative example two
The comparative example provides a kind of medicine for parasitic disease, is grouped as by the group of following parts by weight：Acetylamino Avermectin
Element 0.5%, dibutyl hydroxy toluene 0.02%, lauric acid Azone 5%, ethyl alcohol 10% and propylene glycol surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and mixed with propylene glycol are become into solvent, then by second
Acylamino- avermectin, dibutyl hydroxy toluene and lauric acid Azone sequentially add in solvent, wait for previous component stirring and dissolving
Add next component again afterwards, after stirring and dissolving is complete, obtains above-mentioned medicine for parasitic disease.
Comparative example three
The comparative example provides a kind of medicine for parasitic disease, is grouped as by the group of following parts by weight：Thymol 1%, pyrrole
Quinoline ketone 1%, dibutyl hydroxy toluene 0.02%, lauric acid Azone 5%, ethyl alcohol 10% and propylene glycol surplus.
The preparation method of above-mentioned medicine for parasitic disease is：Ethyl alcohol and mixed with propylene glycol are become into solvent, then by hundred
In fragrant phenol, praziquantel, dibutyl hydroxy toluene and lauric acid Azone sequentially add in solvent, after previous component stirring and dissolving
Again plus next component, after stirring and dissolving is complete, above-mentioned medicine for parasitic disease is obtained.
It will prove the effect of above-described embodiment and comparative example according to experiment below.
Clinical effectiveness is tested：
Clinical test is carried out to embodiment one to example IV and comparative example one to comparative example three.
Testing program：Guangdong Province cattle farm.Dairy bread is Chinese Holstein, and the age is 1 years old -5 years old age, amounts to 80
Head is natural infection nematodiasis and fluke disease.Before experiment anti-parasite medicine is taken without throwing in 60d.It tests milk cow and presses the milk
Cattle farm conventinal breeding method raising.Experiment is divided into 8 groups, every group 10.First group to the 4th group corresponds to administration embodiment one respectively
To example IV, the 5th group to the 7th group is administered comparative example one to comparative example three respectively, and the 8th group is blank group, is not administered.It removes
Outside control group, each group ensures that dosage is identical.
Test method：It offers medicine before object, is wiped clean with dry cotton by milk cow back is tested, dispensing total amount presses per kilogram of body weight
0.5mg acetylamino evericins calculate, and draw trial drug with plastic injector, pour at the position of milk cow wiped clean.
Each cow head excrement is acquired respectively within the 2nd, 5,10,20,30 day, detect its nematode worm's ovum before dispensing, after dispensing.
Egg detecting method：By the quantification of 10g of the excrement of tested milk cow, custard is tuned into 3~5 times of volume of water；80 mesh copper sieve
Side filtering is rinsed in net filtration, appropriate waterside；Filtrate is precipitated into 30min, abandons supernatant, precipitation is added water, is repeated 3 times；It abandons appropriate
Supernatant, with graduated cylinder 5mL quantification of to the precipitated liquid；After fully shaking up precipitated liquid, partly precipitated liquid is moved rapidly with pipette
To two counting chambers of " counter "；Under the microscope, observation counter two counts indoor parasite egg, and counts；It presses
(worm's ovum number × 5ml in two lattice of counter)/(10g × 0.2) formula EPG=calculates EPG values.Test result is shown in Table one.
Table one
After dispensing it can be seen from the test result of table one, the group faecal nematode worm of first 5 days addition example compositions
The negative conversion rate of ovum is apparently higher than the group of addition comparative example composition, but negative conversion rate is 100% after 10 days, shows the composition
With stronger anti-nematode activity, and its antibacterial activity is set to enhance after adding Thymol, the stress reaction of animal also weakens；And
For fluke disease, preferable therapeutic effect is shown, shows that the composition has anti-fluke activity, but add embodiment combination
The negative conversion rate of 5 days excrement fluke worm's ovums is apparently higher than the group of addition comparative example composition before the group of object, illustrates in addition hundred
After fragrant phenol, enhance its antibacterial activity.The group milk cow of addition example composition does not occur uncomfortable or stress reaction, addition comparison
The group of example composition occurs stress reaction, shows that the composition can improve immune response level, alleviates parasite sense
Pathological state caused by dye contributes to the health status and production performance that maintain body.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (13)
1. application of the composition of acetylamino evericin and praziquantel in medicine for parasitic disease.
2. the application in medicine for parasitic disease according to claim 1, which is characterized in that the acetylamino Avermectin
The plain mass ratio with the praziquantel is 1:(0.1-5).
3. the application in medicine for parasitic disease according to claim 1, which is characterized in that the composition further includes hundred
In fragrant phenol.
4. the application in medicine for parasitic disease according to claim 3, which is characterized in that the acetylamino Avermectin
The plain mass ratio with the Thymol is 1:(0.01-5).
5. the application in medicine for parasitic disease according to claim 3 or 4, which is characterized in that acetylamino Ah
The mass ratio for tieing up rhzomorph and the Thymol is 1:2, the mass ratio of the acetylamino evericin and the praziquantel
Example is 1:2.
6. a kind of medicine for parasitic disease, which is characterized in that including acetylamino evericin and praziquantel.
7. medicine for parasitic disease according to claim 6, which is characterized in that the acetylamino evericin with it is described
The mass ratio of praziquantel is 1:(0.1-5).
8. medicine for parasitic disease according to claim 6, which is characterized in that include the component of following parts by weight：Acetyl
Amino avermectin 0.1%-10%, praziquantel 0.1%-10% and auxiliary material surplus.
9. medicine for parasitic disease according to claim 6, which is characterized in that the medicine for parasitic disease further includes hundred
In fragrant phenol.
10. medicine for parasitic disease according to claim 9, which is characterized in that the acetylamino evericin and institute
The mass ratio for stating Thymol is 1:(0.01-5).
11. medicine for parasitic disease according to claim 9, which is characterized in that include the component of following parts by weight：In hundred
Fragrant phenol 0.01%-5%, acetylamino evericin 0.1%-10%, praziquantel 0.1%-10% and auxiliary material surplus.
12. according to claim 6-11 any one of them medicines for parasitic disease, which is characterized in that the anti parasitic disease medicine
Object is tablet, granule, pulvis, oral agents, injection or dashing agent.
13. a kind of method preparing claim 6-12 any one of them medicines for parasitic disease, which is characterized in that by acetyl
Amino avermectin and praziquantel are added in auxiliary material one by one, obtain medicine for parasitic disease；It, will when there is Thymol in drug
Thymol is added in auxiliary material one by one with acetylamino evericin and praziquantel.
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| CN201810709665.8A CN108771684A (en) | 2018-07-02 | 2018-07-02 | The application of the composition of acetylamino evericin and praziquantel, medicine for parasitic disease and preparation method thereof |
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