CN108744102B - Internal filtering enhanced dialyzer - Google Patents
Internal filtering enhanced dialyzer Download PDFInfo
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- CN108744102B CN108744102B CN201810722810.6A CN201810722810A CN108744102B CN 108744102 B CN108744102 B CN 108744102B CN 201810722810 A CN201810722810 A CN 201810722810A CN 108744102 B CN108744102 B CN 108744102B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
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Abstract
An internal filtration enhancement type dialyzer relates to a dialyzer for hemodialysis, which comprises an outer shell and a hollow fiber membrane tow, and is characterized in that: the inner wall of the outer shell is provided with at least one decompression ring, the decompression ring comprises spherical bulges which are integrally made with the outer shell and are uniformly distributed on the axial direction of the inner wall of the outer shell, and an arc-shaped guide plate is arranged on the opposite side of each spherical bulge and the flow direction of the dialysate. The method has the advantages of improving the internal filtration of the dialyzer, simultaneously not introducing non-dialyzer manufacturing materials, fully ensuring the safety of the dialyzer, being safe and reliable to use, high utilization rate of the hollow fiber membrane wires, good treatment effect and the like.
Description
Technical Field
The invention relates to a dialyzer for hemodialysis, in particular to an internal filtration enhancement dialyzer capable of increasing beta 2 microglobulin removal.
Background
With the continuous development of dialysis technology and the continuous and intensive research on uremic toxins, medium and large molecules represented by beta 2 microglobulin are receiving more and more attention. There are two main ways to remove beta 2 microglobulin-adsorption and convection. Most dialyzers use convection to remove beta 2 microglobulin. Conventional low-flux dialyzers are unable to remove beta 2 microglobulin, while increasingly high-flux dialyzers can effectively remove beta 2 microglobulin. The clearance of beta 2 microglobulin by the dialyzer can be changed by changing the pore structure of the dialysis membrane, the dialysate flow and the like. Along with the continuous improvement of the water quality of hemodialysis water, the application of the internal filtration enhancement type dialyzer is also continuously increased, so that the removal performance of beta 2 microglobulin is further enhanced.
Currently, methods to improve filtration in dialyzers are mainly to change the length of the dialyzer starting from the dialysis membrane or to reduce the inner diameter of the hollow fibers or to change the structure of the dialyzer. The above method can enhance the internal filtration of the dialyzer (collectively referred to as internal enhancement filtration) due to the limitations of the dialyzer manufacturing process, but has limited effectiveness.
The national intellectual property agency discloses a patent name applied for 26 days of 12 months in 2003: dialyzer and its manufacturing method, patent number 200310119358.8, which discloses the following technical features: the device is provided with a cylindrical outer shell, wherein a hollow fiber membrane tow is arranged in the outer shell, a cylindrical elastic tube is arranged between the inner wall of the outer shell and the hollow fiber membrane tow, a bulge which is embedded and connected with the inner wall of the outer shell is arranged on the periphery of the elastic tube, and the elastic tube is in liquid-tight contact with the inner wall of the outer shell; the inner cavity of the hollow fiber membrane wire forms a blood chamber, and a dialysate chamber is formed between the inner wall of the outer shell and the hollow fiber membrane wire and between the hollow fiber membrane wires. The dialyser is characterized in that a cylindrical elastic tube is added between the outer shell and the membrane wire to increase the pressure drop of a dialyser, and although the internal filtration of the dialyser is increased, the safety is required to be checked because a non-dialyser manufacturing material is introduced into the outer shell, the outer shell and the cylindrical elastic tube are connected in a concave-convex manner, the stability is poor, and the elastic tube with elasticity is easy to fall off under the impact of 4-hour high-flow-rate dialyser, so that the whole-course effectiveness cannot be ensured; the inner wall of the cylindrical elastic tube is tightly contacted with the hollow fiber membrane wires outside the hollow fiber membrane wire bundles, so that the outer sides of a large part of the hollow fiber membrane wires cannot be contacted with the dialyzate, the utilization rate of the hollow fiber membrane wires is low, and the treatment effect is poor. Meanwhile, due to the existence of the tubular elastomer, the flow of the dialyzate is influenced, and the mass transfer efficiency of the dialyzate is reduced.
Disclosure of Invention
The invention aims to solve the defects of the prior art, and provides the internal filtration enhancement type dialyzer which improves the internal filtration of the dialyzer without introducing non-dialyzer manufacturing materials, fully ensures the safety of the dialyzer, is safe and reliable to use, has high utilization rate of hollow fiber membrane wires and has good treatment effect.
The invention solves the defects of the prior art, adopts the following technical proposal:
An internal filtration enhancement mode dialyzer, includes shell body and hollow fiber membrane silk bundle, its characterized in that: the inner wall of the outer shell is provided with at least one decompression ring, the decompression ring comprises spherical bulges which are integrally made with the outer shell and are uniformly distributed on the axial direction of the inner wall of the outer shell, and an arc-shaped guide plate is arranged on the opposite side of each spherical bulge and the flow direction of the dialysate.
The flow guiding start end of the arc-shaped flow guiding plate is positioned at the central part of the spherical bulge in the axial direction of the outer shell, the flow guiding tail end of the arc-shaped flow guiding plate is positioned at the opposite position of the central part of the spherical bulge adjacent to the spherical bulge at the start end, and the arc-shaped flow guiding plate is tangent to the flow direction of the dialyzing fluid at the flow guiding start end.
The radial width of the arc-shaped guide plate in the outer shell is the same as the height of the spherical bulge.
At least two pressure reducing rings are arranged at the front part or the middle part of the outer shell, and the bending directions of the arc-shaped guide plates of the two adjacent pressure reducing rings are opposite. The dialysate in the outer shell flows from front to back, i.e. the pressure reducing ring is arranged between the dialysate inlet to the middle in the outer shell.
The pressure reducing ring consists of 10-40 spherical bulges, the height of each spherical bulge is 0.01-0.1 times of the inner diameter of the outer shell, and the bottoms of the spherical bulges are sequentially connected at the inner wall of the outer shell.
The central angle of the arc-shaped guide plate is 60-90 degrees, and the surface of the arc-shaped guide plate is smooth and is made of the same material as the shell. The height of the arc-shaped guide plate is consistent with the height of the hemispherical bulges, and the width of the arc-shaped guide plate is 0.5 to 1.5 times of the width of the hemispherical bulges. The liquid flow directions of two adjacent circles of guide plates are opposite.
The spherical bulge provided by the invention has a smooth surface and is the same as the shell. The smooth surface is beneficial to the fluid flow.
The filling density of the hollow fiber membrane tows in the shell is 40-70%.
The space between the inner wall of the outer shell body and the hollow fiber membrane wires through which the dialyzate passes and the space (dialyzate flow path) between the hollow fiber membrane wires are reduced in cross section at the pressure reducing ring in the use process, so that the pressure loss of the dialyzate chamber of the dialyzate is increased, the pressure difference between the dialyzate chamber inlet and the dialyzate blood chamber outlet and the pressure difference between the blood chamber inlet and the dialyzate outlet are increased, and the effect of enhancing internal filtration is achieved. The invention improves the internal filtration of the dialyzer without introducing non-dialyzer manufacturing materials, fully ensures the safety of the dialyzer, and ensures that the pressure reducing ring and the outer shell are made of the same materials integrally, and can not fall off, thus being safe and reliable to use. The ideal state between the pressure reducing ring and the hollow fiber membrane wire is point contact, actually small-area line contact, and the hollow fiber membrane wire has high utilization rate and good treatment effect. Meanwhile, the guide plate is arranged on the decompression ring along the flowing direction of the dialysate, so that the influence of the decompression ring on the flowing of the dialysate is compensated.
Drawings
FIG. 1 is a schematic view of the structure of the outer shell after removing the hollow fiber membrane tows according to the present invention.
Fig. 2 is a schematic cross-sectional view of the present invention at a decompression ring.
Detailed Description
The internal filtration enhancement type dialyzer shown in fig. 1 and 2 comprises an outer shell 1 and a hollow fiber membrane tow 4, wherein the outer shell 1 is cylindrical, the hollow fiber membrane tow 4 is arranged in the outer shell 1, and the filling density of the hollow fiber membrane tow 4 in the outer shell 1 is 40% -70%; the hollow fiber membrane wires form a blood chamber in the inner cavity, and the blood chamber is formed between the inner wall of the outer shell and the hollow fiber membrane wires and between the hollow fiber membrane wires, and the structure is the same as the prior art and is not repeated, and the invention is characterized in that: the inner wall of the outer shell 1 is axially provided with at least one decompression ring, the decompression ring comprises spherical bulges 3 which are integrally made with the outer shell and are uniformly distributed on the inner wall of the outer shell in the axial direction, one decompression ring comprises 10-40 spherical bulges 3, the height (the radial dimension of the outer shell) of each spherical bulge 3 is 0.01-0.1 time of the inner diameter of the outer shell, and the bottoms of the spherical bulges 3 are sequentially connected at the inner wall of the outer shell. An arc-shaped guide plate 2 is arranged on the opposite side of each spherical bulge 3 to the flow direction of the dialysate; the guide starting end of the arc-shaped guide plate 2 is positioned at the central part of the spherical bulge (in the axial direction of the outer shell), and the guide tail end of the arc-shaped guide plate 2 is positioned at the (axial) opposite position of the central part of the spherical bulge (in the axial direction of the outer shell) adjacent to the spherical bulge at the starting end; the arc-shaped guide plate is tangent to the flow direction of the dialysate at the guide starting end, the width direction of the arc-shaped guide plate is arranged along the radial direction of the outer shell, and the radial width of the arc-shaped guide plate is the same as the height of the spherical protrusion.
According to the invention, the middle part in the outer shell is symmetrically provided with two decompression rings at the axial center of the shell, the bending directions of the arc-shaped guide plates of the two adjacent decompression rings are opposite, and the dialysate is prevented from rotating and advancing in the outer shell after passing through the arc-shaped guide plates of the two decompression rings in the same direction.
The spherical bulge in the invention has smooth surface and the material is the same as that of the outer shell; the arc-shaped guide plate is in a quarter arc shape (the central angle is 90 degrees), the surface is smooth, and the arc-shaped guide plate and the shell are made of the same material. The axial dimension of the arc-shaped guide plate on the outer shell is 0.5-1.5 times of that of the hemispherical bulge.
The space between the inner wall of the outer shell body and the hollow fiber membrane wires through which the dialyzate passes and the space (dialyzate flow path) between the hollow fiber membrane wires are reduced in cross section at the pressure reducing ring in the use process, so that the pressure loss of the dialyzate chamber of the dialyzate is increased, the pressure difference between the dialyzate chamber inlet and the dialyzate blood chamber outlet and the pressure difference between the blood chamber inlet and the dialyzate outlet are increased, and the effect of enhancing internal filtration is achieved; the arrangement of the spherical bulges ensures that the dialysate flowing at high speed is unevenly distributed on the opposite sides of the flow direction of the dialysate flowing in the spherical bulges, so that the utilization rate of hollow fiber membrane wires is reduced, and the arc-shaped guide plates guide the dialysate flowing between two adjacent spherical bulges to the opposite sides of the flow direction of the dialysate flowing in the spherical bulges, thereby compensating the uneven distribution of the dialysate caused by the spherical bulges. The invention improves the internal filtration of the dialyzer without introducing non-dialyzer manufacturing materials, fully ensures the safety of the dialyzer, and ensures that the pressure reducing ring and the arc-shaped guide plate are integrally made of the same materials as the outer shell, and can not fall off, thus being safe and reliable to use. The ideal state between the pressure reducing ring and the hollow fiber membrane wire is point contact, actually small-area line contact, and the hollow fiber membrane wire has high utilization rate and good treatment effect. Meanwhile, the arc-shaped guide plates are arranged on the decompression ring along the flowing direction of the dialysate, so that the influence of the decompression ring on the flowing of the dialysate is compensated.
Claims (3)
1. An internal filtration enhancement mode dialyzer, includes shell body and hollow fiber membrane silk bundle, its characterized in that: the inner wall of the outer shell is provided with at least one decompression ring so that the sectional area of the dialysate passing through the space between the inner wall of the outer shell and the hollow fiber membrane wires and the space between the hollow fiber membrane wires is reduced at the decompression ring, the decompression ring comprises spherical bulges which are integrally manufactured with the outer shell and are uniformly distributed in the circumferential direction of the inner wall of the outer shell, and an arc-shaped guide plate is arranged on the opposite side of each spherical bulge and the dialysate flow direction;
The flow guiding start end of the arc-shaped flow guiding plate is positioned at the central part of the spherical bulge in the circumferential direction of the outer shell, the flow guiding tail end of the arc-shaped flow guiding plate is positioned at the opposite position of the central part of the spherical bulge adjacent to the spherical bulge at the start end, and the arc-shaped flow guiding plate is tangent to the flowing direction of the dialyzate at the flow guiding start end;
The spherical bulges and the arc-shaped guide plates are smooth in surface and the material of the spherical bulges and the arc-shaped guide plates is the same as that of the outer shell;
at least two decompression rings are arranged at the front part or the middle part of the outer shell, and the bending directions of the arc-shaped guide plates of the two adjacent decompression rings are opposite;
The radial width of the arc-shaped guide plate on the outer shell is the same as the height of the spherical bulge.
2. The internal filtration-enhanced dialyzer according to claim 1, wherein the one pressure-reducing ring is composed of 10 to 40 spherical protrusions having a height of 0.01 to 0.1 times the inner diameter of the outer case, the bottoms of the spherical protrusions being sequentially connected at the inner wall of the outer case.
3. The internal filtration-enhanced dialyzer according to claim 2, wherein the arc-shaped deflector has a central angle of 60 to 90 ° and has a smooth surface and is made of the same material as the casing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810722810.6A CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810722810.6A CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
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| Publication Number | Publication Date |
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| CN108744102A CN108744102A (en) | 2018-11-06 |
| CN108744102B true CN108744102B (en) | 2024-08-09 |
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| CN201810722810.6A Active CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331270A (en) * | 2018-12-17 | 2019-02-15 | 班遵浦 | A kind of haemodialysis dialyzer |
| CN109718426B (en) * | 2019-02-26 | 2021-09-21 | 京东方科技集团股份有限公司 | Infusion control system and infusion system |
| CN112451774B (en) * | 2020-12-03 | 2025-10-28 | 山东威高血液净化制品股份有限公司 | Adsorption-enhanced dialyzer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003334244A (en) * | 2002-03-14 | 2003-11-25 | Nipro Corp | Dialyzer and manufacturing method therefor |
| CN101361994A (en) * | 2008-09-12 | 2009-02-11 | 北京工业大学 | Artificial heart blood pump that raises blood pressure step by step |
| CN209204252U (en) * | 2018-07-04 | 2019-08-06 | 威海威高血液净化制品有限公司 | The interior enhanced dialyzer of filtration |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5862994A (en) * | 1996-06-25 | 1999-01-26 | Grinnell Corporation | Deflector for upright-type fire sprinklers |
| US20090107335A1 (en) * | 2007-02-27 | 2009-04-30 | Deka Products Limited Partnership | Air trap for a medical infusion device |
| CN205073372U (en) * | 2015-09-25 | 2016-03-09 | 珠海健帆生物科技股份有限公司 | Compound blood purifying device |
| CN116328070A (en) * | 2017-09-12 | 2023-06-27 | 东莞科威医疗器械有限公司 | A spiral diversion integrated membrane oxygenator |
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2018
- 2018-07-04 CN CN201810722810.6A patent/CN108744102B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003334244A (en) * | 2002-03-14 | 2003-11-25 | Nipro Corp | Dialyzer and manufacturing method therefor |
| CN101361994A (en) * | 2008-09-12 | 2009-02-11 | 北京工业大学 | Artificial heart blood pump that raises blood pressure step by step |
| CN209204252U (en) * | 2018-07-04 | 2019-08-06 | 威海威高血液净化制品有限公司 | The interior enhanced dialyzer of filtration |
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| CN108744102A (en) | 2018-11-06 |
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Address after: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Huancui District, Weihai City, Shandong Province 264200 Applicant after: Shandong Weigao blood purification products Co.,Ltd. Address before: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Huancui District, Weihai City, Shandong Province 264200 Applicant before: WEIHAI WEIGAO BLOOD PURIFICATION PRODUCTS Co.,Ltd. |
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