CN108743411A - A kind of method that LBL self-assembly prepares sun-proof Nano capsule - Google Patents
A kind of method that LBL self-assembly prepares sun-proof Nano capsule Download PDFInfo
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- 239000002088 nanocapsule Substances 0.000 title claims abstract description 30
- 238000001338 self-assembly Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 31
- 239000006210 lotion Substances 0.000 claims abstract description 28
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229920001661 Chitosan Polymers 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 239000011162 core material Substances 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000661 sodium alginate Substances 0.000 claims abstract description 8
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 8
- 239000002131 composite material Substances 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000007864 aqueous solution Substances 0.000 claims abstract description 4
- 239000007974 sodium acetate buffer Substances 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 14
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 10
- 239000001632 sodium acetate Substances 0.000 claims description 10
- 235000017281 sodium acetate Nutrition 0.000 claims description 10
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 7
- 239000001110 calcium chloride Substances 0.000 claims description 7
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 6
- DVVXXHVHGGWWPE-UHFFFAOYSA-N 2-(dimethylamino)benzoic acid Chemical compound CN(C)C1=CC=CC=C1C(O)=O DVVXXHVHGGWWPE-UHFFFAOYSA-N 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 abstract description 10
- 238000013329 compounding Methods 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000012875 nonionic emulsifier Substances 0.000 abstract description 2
- 238000003756 stirring Methods 0.000 description 13
- 238000013019 agitation Methods 0.000 description 10
- 239000003643 water by type Substances 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000008351 acetate buffer Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000475 sunscreen effect Effects 0.000 description 5
- 238000002242 deionisation method Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- YDIYEOMDOWUDTJ-UHFFFAOYSA-N 4-(dimethylamino)benzoic acid Chemical compound CN(C)C1=CC=C(C(O)=O)C=C1 YDIYEOMDOWUDTJ-UHFFFAOYSA-N 0.000 description 1
- ZYMCJDAUBJFVSM-UHFFFAOYSA-N 6-methylheptyl 4-(dimethylamino)benzoate Chemical compound CC(C)CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 ZYMCJDAUBJFVSM-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of methods that LBL self-assembly prepares sun-proof Nano capsule, include the following steps：(1) core material, composite emulsifier are placed in beaker；Deionized water is added, in 25-40 DEG C of water-bath；(2) chitosan solution is prepared, acetic acid/sodium acetate buffer dissolving is added, pH is in 3-4.5；(3) step (1) solution, volume ratio 1 is added:1；In 25-40 DEG C of water-bath；(4) sodium alginate aqueous solution is prepared, pH is in 6-8 for control；(5) two level solution is added；(6) curing agent solution is prepared；(7) it is added in curing agent solution, obtains sun-proof Nano capsule.Stable charged drop is prepared as template by compounding nonionic emulsifier and ionic emulsifying agent, and complicated operation such as removing template is gone in release, and wall material thickness is controlled by LBL self-assembly, forms fine and close capsule wall, content is avoided to leak.Average grain diameter is between 200-400nm, and PDI range 0.1-0.3 adapt to ultra light sun block lotion, and cream prepares environment；Gained Nano capsule has the comparable sun-proof result of sun-screening agent.
Description
Technical field
The invention belongs to field of fine chemical, and in particular to a kind of technology of preparing of sun-proof Nano capsule.
Background technology
It is generally known that the ultraviolet light in daylight is divided into three types：Ultraviolet C (200~290 nm), Ultraviolet B (290
~320 nm) and ultraviolet light,long wave (320~400 nm), short wave ultraviolet C pathogenic effects are most strong, but the shortwave contained in daylight is purple
Outside line is almost fully absorbed by ozone layer, and the ultraviolet light for reaching ground is largely long wave ultraviolet, and only a few is that medium wave is ultraviolet
Line.Ultraviolet B radiation B has erythema effect to human body, and long-term or excessive exposure can cause the chronic disease of skin, for example induce
With exacerbation idiopathic illumination skin disease, causes scytitis to react, lead to red and swollen decortication；Long wave ultraviolet A can be attacked through epidermis
Skin corium is hit, enables ossein and elastin laminin in skin be inflicted heavy losses on, and dermal cell self-protection ability is poor, minimal amount
Long wave ultraviolet A just can cause great damage.
With the promotion of people's quality of life, more and more people keep out ultraviolet light using sun-proof chemical product, commonly
Sun-proof chemical product is divided into physical sunscreen and chemical sunscreen, and physical sunscreen is mainly that titanium dioxide and Zinc oxide particles reflection are ultraviolet
Line, due to the characteristic of itself, smearing has sense of discomfort on the skin, and content height can also influence colour of skin beauty etc.；On the contrary, chemistry is anti-
Solarization ultraviolet absorption effect is notable, and chemical compatibility is good, and skin sense is suitble to.Although chemical sun can effectively inhibit ultraviolet in daylight
Beta radiation, but also bring some harm during use：(1) sunscreen products intersect allergic phenomena and photosensitization caused by compounding
Disease.(2) there is penetrability to skin, chemical sun molecular weight is smaller, has very strong skin penetration characteristics, security performance
Receive the concern of people.(3) photo-labile, most sun-screening agents shine degrade under light illumination, are generated in degradation process high
Living radical, damages organism macromolecular and cell, and unsaturated fatty acid in oxysome causes human body blood circulation to be deteriorated,
Influence itself spf value simultaneously.
Chemical sun is used for greater safety, sun-proof Nano capsule is now prepared using LBL self-assembly method, by changing
The thickness for becoming assembling number of plies regulation and control Nano capsule cyst wall, realizes the Controlled release of sun-screening agent.The sun-proof nanometre glue formed after package
Capsule can provide the ultraviolet absorption effect for being equal to sun-screening agent, and promote sun-screening agent more stable, long-acting, mild, and it is green to cater to safety
The demand in the sun-proof market of color.Sun-proof Nano capsule at present on the market is fewer, and sun-proof Nano capsule prepared by the present invention is with steady
It is template to determine charged drop, and the wall material for adding oppositely charged carries out layer assembly, and tight can not only effectively inhibit anti-
The release of agent is shone, also there is good dispersibility and stability, it is good with sun-proof articles compatibility.
Invention content
It is an object of the invention to overcome the shortcomings of at present sunscreen capsule on the market, it is anti-to provide a kind of LBL self-assembly preparation
The method for shining Nano capsule, to solve the problems such as sun-proof Nano capsule preparation process is complicated, template remains, stability is poor.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of method that LBL self-assembly prepares sun-proof Nano capsule, includes the following steps：
(1) core material, composite emulsifier are placed in beaker, the core material and composite emulsifier 1:1-1:2；
Control mixing speed is 250-1250 rpm；
Deionized water is added in beaker, the deionized water is 68%-98% by weight；
In 25-40 DEG C of water-bath 10-30min, obtain stablizing negatively charged drop primary emulsion (NEI)；
(2) chitosan solution is prepared, acetic acid/sodium acetate buffer dissolving is added, control pH value of solution is in 3-4.5；
(3) in the solution in step (2), step (1) solution is added, the two volume ratio is 1:1；
Control mixing speed is 250-1250 rpm；
In 25-40 DEG C of water-bath 10-30min, positively charged drop two level lotion (NEII) is obtained；
(4) sodium alginate aqueous solution is prepared, pH is in 6-8 for control；
(5) in the solution in step (4), step (3) two level solution is added, repeats step (3), obtains negatively charged drop three-level
Lotion (NEIII)；
(6) curing agent solution is prepared, curing agent is 2%-10% by weight；
(7) the three-level lotion in step (5) is added in step (6) curing agent solution, repeats step (3), obtains sun-proof nanometre glue
Capsule.
In the method that above-mentioned LBL self-assembly prepares sun-proof Nano capsule, the core material is that p-(dimethylamino)-benzoic acid is different
Monooctyl ester (EHA)；The wall material is chitosan or sodium alginate；The curing agent is calcium chloride.It is electro-hydraulic that stabilized zone is prepared with core material
Drop is template, wall material sequential deposition, crosslinking in drop template.
In the method that above-mentioned LBL self-assembly prepares sun-proof Nano capsule, the core material is by composite emulsifier (Tween-80
With lauryl both sexes sodium acetate) emulsification formed stablize charged drop, the wall material chitosan, sodium alginate amount fall in a range
Interior, the range is selected from by weight, chitosan 0.025% to 0.25%, sodium alginate 0.05% to 0.1%.
In the method that above-mentioned LBL self-assembly prepares sun-proof Nano capsule, the composite emulsifier is Tween-80 and the moon
Osmanthus base both sexes sodium acetate, weight ratio are Tween-80:Lauryl both sexes sodium acetate=9:1.
Compared with prior art, the present invention has the advantages that：The present invention by compound nonionic emulsifier and from
It is template that sub- emulsifier, which prepares stable charged drop, and release goes complicated operation such as removing template, wall is controlled by LBL self-assembly
Material thickness forms fine and close capsule wall, content is avoided to leak.The capsule is stabilized in aqueous solution, and average grain diameter exists
Between 200-400nm, PDI range 0.1-0.3 adapt to ultra light sun block lotion, and cream prepares environment；Gained Nano capsule has anti-
Shine the comparable sun-proof result of agent.
Description of the drawings
Fig. 1 is sun-proof agent emulsion transmission electron microscope picture obtained by embodiment；
Fig. 2 is sun-proof Nano capsule transmission electron microscope picture obtained by embodiment；
Fig. 3 is Nano capsule grain size distribution obtained by embodiment；
Fig. 4 is sun-proof Nano capsule UV absorption figure obtained by embodiment；
Fig. 5 is sun-proof Nano capsule change of size figure obtained by embodiment；
Fig. 6 is sun-proof Nano capsule potential change figure obtained by embodiment；
Fig. 7 is sun-proof Nano capsule tablets in vitro figure obtained by embodiment.
Specific implementation mode
The invention will be further described in conjunction with the embodiments.
Embodiment 1：
Lauryl both sexes sodium acetate 0.05g is weighed in 50mL beakers, 0.45g Tween-80s are added, stirs evenly, adds
0.5g isooctyl p-dimethylaminobenzoate, stirs evenly, and is placed in 25 DEG C of water-baths, controls rotating speed r=750rpm, and 49mL is added
Deionized water reacts 15min.It obtains stablizing negatively charged drop primary emulsion (NEI).Accurately weighing 0.01g chitosans is placed in burning
In cup, acetic acid/acetate buffer solution 40mL of pH=4.5, magnetic agitation dissolving is added.40mL primary emulsions are taken, at 25 DEG C, stirring
Speed r=750, are added dropwise in chitosan solution, react 15min, obtain positively charged two level lotion (NEII).Accurately weigh
0.01g sodium alginates are placed in beaker, and 20mL deionized waters are added, and 20mL two level lotions are added, 25 in magnetic agitation dissolving
DEG C, mixing speed r=750 react 15min, obtain electronegative three-level lotion (NEIII).Really weighing 1.6g calcium chloride is placed in burning
In cup, 20mL deionized waters are added, are eventually adding 20mL three-level lotions, at 25 DEG C, mixing speed r=750, reaction 15min is obtained
Nano capsule.
Embodiment 2：
Lauryl both sexes sodium acetate 0.2g is weighed in 50mL beakers, 1.8g Tween-80s are added, stirs evenly, adds 1g pairs
The different monooctyl ester of dimethylaminobenzoic acid, stirs evenly, and is placed in 25 DEG C of water-baths, controls rotating speed r=1250rpm, and 47mL deionizations are added
Water reacts 15min.It obtains stablizing negatively charged drop primary emulsion (NEI).It accurately weighs 0.01g chitosans to be placed in beaker, add
Enter acetic acid/acetate buffer solution 40mL of pH=4.5, magnetic agitation dissolving.40mL primary emulsions are taken, at 25 DEG C, mixing speed r=
1250, it is added dropwise in chitosan solution, reacts 15min, obtain positively charged two level lotion (NEII).It is accurate to weigh the seas 0.01g
Mosanom is placed in beaker, and 20mL deionized waters are added, and 20mL two level lotions are added in magnetic agitation dissolving, at 25 DEG C, stirring speed
R=1250 are spent, 15min is reacted, obtains electronegative three-level lotion (NEIII).It really weighs 1.2g calcium chloride to be placed in beaker, add
Enter 20mL deionized waters, be eventually adding 20mL three-level lotions, at 25 DEG C, mixing speed r=1250, reaction 15min obtains nanometre glue
Capsule.
Embodiment 3：
Lauryl both sexes sodium acetate 0.6g is weighed in 50mL beakers, 5.4g Tween-80s are added, stirs evenly, adds 4g pairs
The different monooctyl ester of dimethylaminobenzoic acid, stirs evenly, and is placed in 25 DEG C of water-baths, controls rotating speed r=1000rpm, and 40mL deionizations are added
Water reacts 15min, obtains stablizing negatively charged drop primary emulsion (NEI).It accurately weighs 0.04g chitosans to be placed in beaker, add
Enter acetic acid/acetate buffer solution 40mL of pH=3.5, magnetic agitation dissolving.40mL primary emulsions are taken, at 25 DEG C, mixing speed r=
1000, it is added dropwise in chitosan solution, reacts 15min, obtain positively charged two level lotion (NEII).It is accurate to weigh the seas 0.08g
Mosanom is placed in beaker, and 40mL deionized waters are added, and 40mL two level lotions are added in magnetic agitation dissolving, at 25 DEG C, stirring speed
R=1000 are spent, 15min is reacted, obtains electronegative three-level lotion (NEIII).It really weighs 1.0g calcium chloride to be placed in beaker, add
Enter 20mL deionized waters, be eventually adding 20mL three-level lotions, at 25 DEG C, mixing speed r=1000, reaction 15min obtains nanometre glue
Capsule.
Embodiment 4：
Lauryl both sexes sodium acetate 0.4g is weighed in 50mL beakers, 3.6g Tween-80s are added, stirs evenly, adds 4g pairs
The different monooctyl ester of dimethylaminobenzoic acid, stirs evenly, and is placed in 25 DEG C of water-baths, controls rotating speed r=500rpm, and 42mL deionizations are added
Water reacts 10min.It obtains stablizing negatively charged drop primary emulsion (NEI).It accurately weighs 0.1g chitosans to be placed in beaker, add
Enter acetic acid/acetate buffer solution 40mL of pH=4, magnetic agitation dissolving.40mL primary emulsions are taken, at 25 DEG C, mixing speed r=500,
It is added dropwise in chitosan solution, reacts 10min, obtain positively charged two level lotion (NEII).Accurately weigh 0.2g sodium alginates
It being placed in beaker, 40mL deionized waters is added, 40mL two level lotions are added in magnetic agitation dissolving, at 25 DEG C, mixing speed r=
500,10min is reacted, electronegative three-level lotion (NEIII) must be obtained.It really weighs 0.4g calcium chloride to be placed in beaker, be added
20mL deionized waters are eventually adding 20mL three-level lotions, and at 25 DEG C, mixing speed r=500, reaction 10min obtains Nano capsule.
Embodiment 5：
Lauryl both sexes sodium acetate 0.4g is weighed in 50mL beakers, 3.6g Tween-80s are added, stirs evenly, adds 2g pairs
The different monooctyl ester of dimethylaminobenzoic acid, stirs evenly, and is placed in 40 DEG C of water-baths, controls rotating speed r=250rpm, and 44mL deionizations are added
Water reacts 30min.It obtains stablizing negatively charged drop primary emulsion (NEI).It accurately weighs 0.1g chitosans to be placed in beaker, add
Enter acetic acid/acetate buffer solution 40mL of pH=3, magnetic agitation dissolving.40mL primary emulsions are taken, at 25 DEG C, mixing speed r=250,
It is added dropwise in chitosan solution, reacts 30min, obtain positively charged two level lotion (NEII).Accurately weigh 0.2g sodium alginates
It being placed in beaker, 40mL deionized waters is added, 40mL two level lotions are added in magnetic agitation dissolving, at 25 DEG C, mixing speed r=
250,30min is reacted, electronegative three-level lotion (NEIII) must be obtained.It really weighs g calcium chloride to be placed in beaker, 20mL is added
Deionized water is eventually adding 20mL three-level lotions, and at 25 DEG C, mixing speed r=250, reaction 30min obtains Nano capsule.
Claims (4)
1. a kind of method that LBL self-assembly prepares sun-proof Nano capsule, it is characterised in that include the following steps：
(1) core material, composite emulsifier are placed in beaker, the core material and composite emulsifier 1:1-1:2；
Control mixing speed is 250-1250 rpm；
Deionized water is added in beaker, the deionized water is 68%-98% by weight；
In 25-40 DEG C of water-bath 10-30min, obtain stablizing negatively charged drop primary emulsion；
(2) chitosan solution is prepared, acetic acid/sodium acetate buffer dissolving is added, control pH value of solution is in 3-4.5；
(3) in the solution in step (2), step (1) solution is added, the two volume ratio is 1:1；
Control mixing speed is 250-1250 rpm；
In 25-40 DEG C of water-bath 10-30min, positively charged drop two level lotion is obtained；
(4) sodium alginate aqueous solution is prepared, pH is in 6-8 for control；
(5) in the solution in step (4), step (3) two level solution is added, repeats step (3), obtains negatively charged drop three-level
Lotion；
(6) curing agent solution is prepared, curing agent is 2%-10% by weight；
(7) the three-level lotion in step (5) is added in step (6) curing agent solution, repeats step (3), obtains sun-proof nanometre glue
Capsule.
2. the method that LBL self-assembly as described in claim 1 prepares sun-proof Nano capsule, which is characterized in that the core material is pair
The different monooctyl ester of dimethylaminobenzoic acid；The wall material is chitosan or sodium alginate；The curing agent is calcium chloride.
3. the method that LBL self-assembly as described in claim 1 prepares sun-proof Nano capsule, which is characterized in that
The addition weight of the chitosan is 0.025%-0.25%, and the addition weight of sodium alginate is 0.05%-0.1%.
4. the method that LBL self-assembly as described in claim 1 prepares sun-proof Nano capsule, which is characterized in that the compound emulsion
Agent is that Tween-80 and lauryl both sexes sodium acetate mix, and weight ratio is Tween-80:Lauryl both sexes sodium acetate=9:1.
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