CN108697125A - Moisture supplement agent - Google Patents
Moisture supplement agent Download PDFInfo
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- CN108697125A CN108697125A CN201780011727.1A CN201780011727A CN108697125A CN 108697125 A CN108697125 A CN 108697125A CN 201780011727 A CN201780011727 A CN 201780011727A CN 108697125 A CN108697125 A CN 108697125A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/60—Drinks from legumes, e.g. lupine drinks
- A23L11/65—Soy drinks
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
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- Agronomy & Crop Science (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and for acid moisture supplement agent.The characteristic that moisture supplement agent has absorption of the moisture into organism fast.
Description
The reference of related application
Present patent application based on 2 months 2016 Japanese publication Patent 2016-32302 CLAIM OF PRIORITYs filed in 23 days,
The complete disclosure of the Japanese publication becomes a part for the present application content by reference.
Technical field
The present invention relates to contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and for acid moisture supplement
With agent.
Background technology
Not only when operation during exercise, under hot weather, but also in the environment of high temperature and humidity, even the rooms such as sleep
Interior daily routines are also easy to that exsiccosis, heatstroke occurs.In particular, (internal total comprising water and electrolyte for body fluid volume
Amount of moisture) it reduces and important meal size is also easy to the People reduced, is easy to be affected by temperature for moisture intake
Children (0~15 years old), it is not noticeable dewatering symptom to occur and the so-called heatstroke because of hidden dehydration that gradually becomes exsiccosis becomes
Serious problem.
In order to deal with heatstroke, (heat release) will effectively be discharged by the heat of the generations such as movement, operation, daily routines by, which needing, arrives
In vitro, body temperature is adjusted.Moreover, when the heat release, with by the thermal diffusion carried out to the heat transfer of extraneous air as a purpose
Skin blood flow increase and to pass through the increase for the thermal diffusion volume of perspiration as a purpose that the evaporation of sweat carries out.Therefore,
In order to deal with heatstroke (prevent and mitigate), need to keeping the skin wet rapidly in vivo, and keep.
Although cow's milk keeps the ability of absorbed moisture excellent, the casein as the ingredient in cow's milk is in stomach
Solidification, therefore have stomach discharge slow compared with water, sports drink, moisture is to the slow problem of body absorption.
On the other hand, in being moved with supplement the carbohydrate that consumes and the electrolyte lost by perspiration as a purpose, usually
Using cooperation carbohydrate, the sports drink of electrolyte, reported so far with moisture supplement related validity (for example, referring to
Non-patent literature 1 and 2).However report, from the viewpoint of moisture is kept so for a long time in vivo, these sports drinks
Not necessarily fully, not as good as cow's milk (for example, referring to non-patent literature 3).
Oral rehydration liquid (Oral Rehydration Solution:ORS it is) that a large amount of abdomens for losing sodium occur in order to treat
Exsiccosis in the cholera rushed down and the beverage developed.It includes a large amount of sodium to be mostly, with forcing down, low as being permeated compared with body fluid
Ooze the beverage that the mode of (hypotonic solution) adjusts.However, if will be in order to treat the exsiccosis with vomiting, disease as diarrhea
And the oral rehydration liquid designed then according to circumstances, has for the moisture supplement in the movement, operation, daily routines of healthy person
When can induce hypernatremia, go down for a long time, hypertension can be induced.
The plasma volume using gel-form composition as active ingredient is disclosed in patent document 1 and increases accelerating agent, but this is solidifying
Jelly composition contains calcium, entirely different with the diet product of the present invention.
It discloses in patent document 2 and is combined comprising the acidic protein of protein derived from aqueous protein isolate
Object, but caseinate is substantially free of in the composition, this point is entirely different with the diet product of the present invention.
Existing technical literature
Patent document
Patent document 1:Japanese Unexamined Patent Publication 2004-137268 bulletins
Patent document 2:Japanese Unexamined Patent Application Publication 2014-509525 bulletins
Non-patent literature
Non-patent literature 1:Chang,C.Q et al.,"Effects of a carbohydrate-electrolyte
beverage on blood viscosity after dehydration in healthy adults,"Chin.Med.J.,
2010,123(22),3220-3225
Non-patent literature 2:Shirreffs,S.M et al.,"Rehydration after exercise in the
heat:a comparison of 4 commonly used drinks,"Int.J.Sport Nutr.Exerc.Metab.,
2007,17,244-258.
Non-patent literature 3:Shirreffs,S.M et al.,"Milk as an effective post-exercise
rehydration drink,"Br.J.Nutr.,2007,98,173-180.
Invention content
The object of the present invention is to provide the moisture supplement agent of the fast characteristic of absorption with moisture into organism.
The inventors of the present invention, which have been found that, will contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and is acid
Mixture absorbed together with moisture, then water is absorbed into organism rapidly, to develop the moisture supplement agent.In addition
Also it was unexpectedly observed that the moisture supplement agent is discharged the moisture being ingested is by long-time not as urine, Ke Yi
Internal long time retaining water content.The present invention is proposed based on these understanding.
According to the present invention, following invention is provided.
[1]A kind of moisture supplement agent contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and is
It is acid.
[2]Moisture supplement agent according to (1) is used to supplement holding moisture.
[3]Moisture supplement agent according to (1) or (2), a concentration of 2~7 weight % of lactoprotein.
[4]Moisture supplement agent according to any one of (1)~(3), na concn are 0.005~0.1 weight %.
[5]Moisture supplement agent according to any one of (1)~(4), concentration of saccharide are 0.1~10 weight %.
[6]Moisture supplement agent according to any one of (1)~(5), carbohydrate include selected from trehalose, sucrose, different
One or more of maltulose, maltose, lactose, glucose and dextrin.
[7]Moisture supplement agent according to any one of (1)~(6), stabilizer contain 0.2~1.2 mass %'s
The insoluble fibrin of the threadiness of soybean polysaccharides, the HM pectin of 0.1~0.5 mass % and 0.01~0.1 mass %.
[8]The pH value of moisture supplement agent according to any one of (1)~(7), moisture supplement agent is 3~6.
[9]A kind of newborn diet product of moisture supplement, contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient,
And it is acidity.
[10]The newborn diet product of moisture supplement according to (9), is milk beverage.
[11]A kind of moisture compensation process, it includes the moisture for making object absorb described in any one of (1)~(8) to supplement use
The newborn diet product of moisture supplement described in agent or (9) or (10).
[12]Contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and exists for acid moisture supplement agent
Manufacture the application in diet product or the drug for keeping the skin wet.
[13]A kind of diet product or drug for keeping the skin wet contains lactoprotein, sodium, carbohydrate and stabilizer conduct
Active ingredient, and be acidity.
[14]A kind of application of diet product or drug, for keeping the skin wet, above-mentioned diet product or drug contain lactoprotein,
Sodium, carbohydrate and stabilizer are acidity as active ingredient.
According to the present invention it is possible to provide the moisture supplement agent of the fast characteristic of absorption with moisture into organism.This
Outside, preferred embodiment according to the present invention, can provide that absorption with from moisture to organism is fast and moisture in vivo
The moisture of the characteristic kept for a long time supplements holding agent.
Description of the drawings
Fig. 1 shows the plasma volume change rates (%) that beverage takes orally each moment after granting.
Fig. 2 indicates that beverage takes orally the accumulated urinary excretion amount (mL) at each moment after granting.
Specific implementation mode
Moisture supplement (using) agent of the present invention is to contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and be
Acid moisture supplement agent.The characteristic that the agent of the moisture supplement of the present invention has absorption of the moisture into organism fast, therefore
Can mitigate rapidly, prevent exsiccosis, heatstroke etc..
The moisture supplement of the present invention includes not only the moisture supplement agent containing aftermentioned specified amount moisture with agent, but also is wrapped
The moisture supplement agent of moisture containing the amount containing discontented specified amount moisture, the moisture supplement for substantially eliminating specified amount moisture
With agent.Moisture supplement agent for the present invention is mended in the moisture for absorbing or granting the amount of moisture comprising discontented specified amount moisture
Fill with agent, substantially eliminate the moisture supplement agent of specified amount moisture when, necessary amount moisture and the moisture supplement agent is same
When or separately absorb or grant.
About the moisture supplement agent of the present invention, including the moisture supplement agent of aftermentioned specified amount moisture is from absorbing or grant
The viewpoints consideration such as facility be preferred.Specified amount moisture is absorbed or is granted simultaneously by such moisture supplement agent, is conduct
Including the mixture of specified amount moisture and adjust.That is, preferred embodiment according to the present invention, is provided containing lactoprotein, sodium, sugar
Class, stabilizer and water are as active ingredient and are acid moisture supplement agent.
In the present invention, so-called " active ingredient " refers in terms of playing moisture supplementary result and/or water retention effect
Necessary ingredient, preferably refer in be not easy to keep the skin wet in vivo and/or keep in vivo moisture environment and/or
The object of state plays necessary ingredient in terms of moisture supplementary result and/or water retention effect.
In the present invention, so-called " in be not easy to keep the skin wet in vivo and/or keep in vivo moisture environment and/or
The object of state " refers to the object that body fluid, i.e., internal moisture and/or electrolyte are easily reduced, can enumerate for example, carrying out flesh
Indoor daily routines, particularly the high temperature such as the persistent movements such as meat strength building, the operation of the inferior outdoor of hot weather and sleep
The object of daily routines under mostly wet environment.Daily work in the environment of persistent movement, outdoor operation or high temperature and humidity
When dynamic, it is prone to be dehydrated.Therefore, reserve army of the object of the moisture supplement agent of the present invention comprising exsiccosis, heatstroke is absorbed
(hidden dehydrator etc.) and people with exsiccosis, heatstroke.
The object for absorbing the moisture supplement agent of the present invention, as long as requiring supplementation with internal moisture and/or protecting in vivo
The object of water holding point, is just not particularly limited, in the case of human, specifically, be comparable to the weight of each object 1~
The loss of water of 9 weight % etc., or predict the people of forfeiture.Here, the weight loss caused by the forfeiture of the moisture such as perspiration is 1
It is classified as slight exsiccosis when~2 weight %, when 3~9 weight % is classified as the exsiccosis of moderate, 10 weight % or more
When be classified as the exsiccosis of height.In addition, also including the animal (objects for appreciation such as the domestic animals such as horse, ox, dog, cat other than people in the object
The appreciation animal etc. raised in reward animal, zoo etc.).
If the moisture supplement of the present invention is simultaneously or separately required with specified amount moisture with agent and supplements internal moisture
Object absorbs, then can keep the skin wet rapidly.Here, so-called " rapid ", can after intake water, such as 60 minutes with
It is interior, within preferably 30 minutes, so that internal plasma volume is increased within more preferably 15 minutes.Therefore, according to the present invention excellent
Scheme is selected, moisture (quick) (for example, within 60 minutes) supplement agent immediately is provided.
In addition, if the moisture supplement of the present invention is simultaneously or separately required with specified amount moisture with agent and keeps water in vivo
Point object intake, then moisture that can be in long-time keeping body.Here, so-called " long-time ", according to being not easy in keeping body
Environment and/or the state of moisture and suitably change, refer to the time for playing desirable water retention effect.Specifically, institute
It calls " long-time ", refers in common daily routines, 2 hours after preferably absorbing, 3 hours after more preferably absorbing, into one
4 hours after step preferably intake, 6 hours after further preferably absorbing, 7 hours after further preferably absorbing, particularly preferably
For 8 hours after intake, the moisture simultaneously or separately absorbed with agent with moisture supplement of the invention can be kept in vivo.Therefore,
Preferred embodiment according to the present invention provides moisture supplement long-term (for example, 2 hours or more) holding agent.
So-called moisture supplementary result (effect, function) refers to that (or moisture supplement is kept with the moisture supplement agent of the present invention
Agent) major part of moisture simultaneously or separately absorbed can be in vivo blood plasma in exist.In addition, so-called moisture supplementary function,
For example, can confirm by using the comparative test of the plasma volume of rat, specifically, in the intake of experimental liquid and distilled water
In time afterwards, if compared with the case where taking in the distilled water of the moisture same amount of experimental liquid, experimental liquid is being taken in
In the case of plasma volume it is high, then may determine that as notable (for example, referring to following test examples 1).Moreover, more specifically, so-called water
Divide supplementary function, can be confirmed by plasma volume change rate (%).
So-called water retention effect (effect, function) refers to that (or moisture supplement is kept with the moisture supplement agent of the present invention
Agent) major part of moisture simultaneously or separately absorbed is discharged not as urine, and can keep for a long time in vivo.In addition, institute
Water tariff collection effect is called, for example, can confirm by the comparative test of the urinary excretion of rat, specifically, in experimental liquid
In the time after the intake of distilled water, if compared with the case where taking in the distilled water of the moisture same amount of experimental liquid,
Urinary excretion is few in the case of taking in experimental liquid, then may determine that as notable (for example, referring to following test examples 2).Here, exist
In the case of taking in distilled water, about 2 hours after intake, about the 80% of intake is discharged as urine.Moreover, more specific
For, so-called water tariff collection effect can be confirmed, moisture retention (%) can be by formula 1 by moisture retention:[1- (homalurias
Amount/intake) ]× 100 calculate.
According to a preferred embodiment of the invention, for example, for moisture supplement agent of the invention, 15 points after intake
Clock, plasma volume change rate (%) is, for example, 3% or more, preferably 5% or more, more preferably 7% or more, further preferably
10% or more.
According to a preferred embodiment of the invention, for example, for the present invention moisture supplement with agent (or moisture supplement protect
Hold agent), 2 hours after intake, moisture retention 65%, preferably 70%, more preferably 80%, further preferably
85%, further preferably 90%.
The moisture supplement agent (or moisture supplement retention agent) of the present invention can long time retaining water content in vivo.That is, this
The moisture supplement agent of invention is due to excellent water retention effect, as long as can absorb and (grant) in vivo fully
Moisture, then need not repeatedly be absorbed in the short time.Therefore, can make the object for keeping moisture in vivo is needed to absorb (to apply
With) intake (granting) of the moisture supplement agent of the present invention is spaced, such as makes taking the photograph for the first time from moisture supplement agent of the invention
It gets and is divided at least 0.5 hour the interval of the intake of next time or the intake from the intake of next time to next time.Above-mentioned intake
It is preferably spaced at least 1 hour, more preferably at least 2 hours, more preferably at least 3 hours, more preferably at least 4
Hour, more preferably at least 5 hours, more preferably at least 6 hours, particularly preferably at least 7 hours, most preferably
At least 8 hours.In addition, making to need the intake for the moisture supplement agent for keeping the object of moisture to absorb and (grant) present invention in vivo
Number is not particularly limited, as long as can absorb (grant) in vivo, sufficient moisture can be supplemented, then for it is primary, i.e. one
The intake of gas (one time).Here, in vivo adequately the intake of moisture according to being not easy to keep moisture in vivo
Environment and/or state and suitably change, be in the case of human 50~1000ml, preferably 100~1000ml, more preferably
150~1000ml, further preferably 200~1000ml, particularly preferably 250~1000ml.
The method (or the method granted) for making moisture supplement agent of the invention simultaneously or separately be absorbed with specified amount moisture
Can according to its object and purposes and from orally ingestible (or oral grant), it is enteral grant, gastrostomy etc. suitably selects, but
Preferably orally ingestible (or take orally and grant).
By making the moisture supplement of the present invention simultaneously or separately be absorbed with agent and specified amount moisture, exsiccosis may be implemented
Prevention and the prevention and mitigation of mitigation and then heatstroke.That is, the moisture supplement of the present invention uses agent can be as exsiccosis or heatstroke
Prevent (use) agent and/or treatment (use) agent uses.
The moisture supplement of the present invention is preferably that moisture supplements holding agent with agent.The moisture supplement of the present invention keeps (use) agent
The characteristic for absorbing fast and moisture and keeping for a long time in vivo with from moisture to organism.The moisture supplement of the present invention is protected
It holds with agent by having characteristics that, exsiccosis, heatstroke etc. can mitigated rapidly, and dehydration can be effectively performed
The prevention this respect of disease, heatstroke etc. is advantageous.
The moisture supplement agent of the present invention and moisture supplement holding agent before movement in after, when getting up, before sleep, wash
Bath, after drinking, hot day etc. keeps the skin wet or keeps when moisture to be particularly effective.In addition, the present invention the agent of moisture supplement with
Moisture supplements holding with agent not only for the object moved, and the child for needing moisture supplement, keeping, needs answer
Pay the People of heatstroke, physical labourer is also particularly useful.
In the present invention, so-called " moisture supplement " is the meaning of the fast characteristic of absorption based on moisture into organism, only
Refer to this meaning, or other terms." agent of moisture supplement " can be said differently as example " moisture absorption promotes
With agent ", " moisture absorption improvement agent ", " moisture quickly supplement agent ", " moisture supplement raising agent ", " blood volume, which increases, to be promoted
Into with agent ", " moisture increases promotion agent ", " plasma volume increases promotion agent ", " blood volume restores promotion agent ", " moisture is extensive
Multiple promotion agent " or " plasma volume restores promotion agent " etc..
In the present invention, so-called " moisture supplement keep " is that absorption based on from moisture to organism is fast and moisture is in life
The meaning of the characteristic kept for a long time in object, as long as referring to this meaning, so that it may with for other terms." moisture supplement keeps using
Agent " can be said differently as such as " moisture absorption keeps promotion agent ", " moisture absorption keeps improvement agent ", " moisture supplements
Holding raising agent ", " blood volume increase promotes holding agent ", " moisture restores to promote holding agent " or " plasma volume increase rush
Into holding agent " etc..
The pH value of moisture supplement agent about the present invention, as long as it is acid, it is just not particularly limited, preferably 3~6,
More preferably 3~5, further preferably 3.5~4.5.By making the pH value of the moisture supplement agent of the present invention be 3~6, to
Moderately feeling tart flavour, with acceptable high salubrious flavor this respect be preferred.
As long as the lactoprotein that the moisture supplement agent of the present invention is included is from the protein of breast, just without special
Limitation, can be for example, the sources such as cow's milk, sheep breast, goat dairy, buffalo's milk, sheep breast, bactrian camel milk, whale breast, dolphin breast, human milk
In the lactoprotein of the breast of mammal.In addition, the lactoprotein that the moisture supplement agent about the present invention is included, can enumerate
For example, including whey protein, casein protein, whey protein decomposition, casein with certain concentration (content)
The lactoprotein of matter decomposition product, peptide or amino acids ingredient.It is somebody's turn to do " lactoprotein ", can will be detached and/or be refined respectively
, whey protein, casein protein, whey protein decomposition, casein protein decomposition product, peptide or amino acids
Ingredient is mixed in a manner of as certain concentration and is used, alternatively, it includes not divided with specific concentration that can also use
Fen Li and/or not refining, whey protein, casein protein, whey protein decomposition, casein protein are decomposed
The raw material (raw material) of object, peptide or amino acids ingredient, diet product etc..At this point, " lactoprotein " used in the present invention,
Whey protein, casein protein, whey protein decomposition, casein protein decomposition product, peptide, non-protein state are not needed
Separation process, the refining step of nitrogen component, from the aspect of their manufacturing expenses are cheap, preferably to include with specific concentration
Whey protein, casein protein, whey protein decomposition, casein protein decomposition product or peptide and amino acids
Raw material, diet product of ingredient etc. are used as main component, as needed, by whey protein refined respectively, casein protein,
Whey protein decomposition, casein protein decomposition product or peptide and amino acids ingredient are in a manner of as certain concentration
It mixes and uses.
The moisture supplement of the present invention can be used alone breast with the lactoprotein that agent is included, and can also be used in mixed way 2
Kind or more breast.Moreover, the lactoprotein can use the ingredient of high-purity as chemicals (reagent etc.), it can also use and divide
From blending constituent as object, refined substance.Here, protein content such as can based on information well known to food composition table come
It calculates, in addition it is also possible to be measured that by calculated by customary ways such as Kjeldahl's method, Lao Lifa.In fact, in kjeldahl determination
In the case of method, the nitrogen that various protein are included can be measured, nitrogen-protein conversion coefficient (usual 6.25) are multiplied by its value
And it calculates.
The lactoprotein that the moisture supplement agent of the present invention is included can include casein, the so-called breast for including casein
Protein refers to the lactoprotein being made of casein protein and whey protein.Here, moisture supplement agent of the invention
In, the ratio of the weight of casein protein and whey protein is with (casein protein):(whey protein) is counted, can be with
It is such as 20:1,15:1,12:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:
5,1:6,1:7,1:8,1:9,1:10,1:12,1:15,1:20.That is, the present invention moisture supplement agent in, casein
The ratio of matter and the weight of whey protein is with (casein protein):(whey protein) is counted, and can be such as 20~1:1~
20, preferably 15~1:1~15, more preferably 12~1:1~12, further preferably 10~1:1~10, further preferably
9~1:1~9, further preferably 8~1:1~8, further preferably 7~1:1~7, further preferably 6~1:1~6,
Further preferably 5~1:1~5, further preferably 4~1:1~4, further preferably 3~1:1~3, further preferably
It is 2~1:1~2.
According to preferred embodiment, the casein protein in the lactoprotein that moisture supplement agent of the invention is included and breast
The ratio of the weight of albumin matter is with (casein protein):(whey protein) is counted, and can be such as 5~3:2~0.5, it is excellent
It is selected as 4:1.
(10 DEG C) of the viscosity of the moisture supplement agent of the present invention is such as 3~30mPas, preferably 3.5~30mPa
S, more preferably 4~30mPas, further preferably 4.5~30mPas, further preferably 5~30mPas, into one
Step is preferably 5.5~29mPas, further preferably 6~28mPas, further preferably 6.5~27mPas, into one
Step preferably 7~26mPas, further preferably 7.5~25mPas, further preferably 8~24mPas, further
Preferably 8.5~23mPas, further preferably 9~22mPas, further preferably 9.5~21mPas, further
Preferably 10~20mPas.The viscosity is general Brooker can be used luxuriant and rich with fragrance by the viscosity of Type B rotary viscosity design determining
The measurement such as your moral viscosimeter.(10 DEG C) of the viscosity of moisture supplement agent through the invention is higher than 3mPas, in the present invention
Moisture supplement with agent include casein protein in the case of, the destabilization by the casein protein can be prevented
The separation of caused moisture supplement agent and precipitation are preferred from the aspect of.In addition, moisture supplement through the invention is used
(10 DEG C) of the viscosity of agent is less than 30mPas, even the moisture to the lactoprotein containing casein containing hign concentration is mended
It fills and uses agent, be also possible to prevent no longer to be low viscosity and be easy to the form drunk, be therefore preferred.
The concentration for the lactoprotein that moisture supplement agent about the present invention is included, as long as playing the effect of the present invention,
It is just not particularly limited, preferably 2~7 weight %, more preferably 3~5 weight %.
The concentration for the sodium that moisture supplement agent about the present invention is included does not have as long as playing the effect of the present invention
Especially limitation, preferably 0.005~0.1 weight %, more preferably 0.01~0.05 weight %, further preferably 0.01~
0.02 weight %.Here, na concn such as can be based on food composition table well known to information calculate, furthermore, it is possible to by used
Method is measured and is calculated.The sodium that the moisture supplement agent of the present invention is included can use chemicals (reagent etc.) such
The ingredient of high-purity can also use the raw material comprising sodium, diet product, it is, for example, possible to use from the breast for including sodium of breast
Raw material, dairy products.
There is no limit can lift for the source for the carbohydrate (carbohydrate) that the moisture supplement agent of the present invention is included, form
Go out for example, lactose, granulated sugar, fructose, glucose, maltose, trehalose, isomaltoketose (as commercially available product, can enumerate for example,
パ ラ チ ノ ー ス (Shin Mitsui Sugar Co. Ltd's system)), oligosaccharides, dextrin, starch, food fiber.Moreover, prolonged improving
In terms of water retention effect, which is preferably lactose, granulated sugar, glucose, maltose, trehalose, isomaltoketose or dextrin.
In addition, the carbohydrate can be used alone, can also be mixed with two or more.Here, concentration of saccharide can for example be based on food
Information well known to product component list etc. calculates, furthermore, it is possible to be measured that by calculated by customary way.Carbohydrate used in the present invention
The ingredient that high-purity as chemicals (reagent etc.) can be used, can also use the raw material comprising carbohydrate, diet product, example
Such as, dairy milk starting material, the dairy products for including carbohydrate (principal component is lactose) from breast can be used.Alternatively, the carbohydrate can incite somebody to action
As carbohydrate, well known food additives uses in a manner of as desired concentration.
The carbohydrate that moisture supplement agent about the present invention is included, as long as playing the effect of the present invention, without special
Limitation, for example, comprising in trehalose, sucrose, isomaltoketose, maltose, lactose, glucose and dextrin it is a kind of with
On, trehalose and/or isomaltoketose are preferably comprised, more preferably includes trehalose.By the moisture supplement agent for making the present invention
Containing trehalose, separation and the precipitation of moisture supplement agent can be inhibited, redispersibility is also good, further assign low viscosity and
It is easy to the feature of form drunk.Trehalose can be also commercially available, and can be used for example, ト レ Ha (Lin Yuan societies system).
The concentration for the carbohydrate that moisture supplement agent about the present invention is included does not have as long as playing the effect of the present invention
There are special limitation, preferably 0.1~10 weight %, more preferably 1~6 weight %, further preferably 2~3 weight %.
The stabilizer that moisture supplement agent about the present invention is included, as long as playing the effect of the present invention, without spy
It does not limit, can preferably enumerate the insoluble fibrin of soybean polysaccharides, HM pectin or threadiness, further preferably 0.2~1.2 weight
Measure the insoluble fibre of the threadiness of the soybean polysaccharides of %, the HM pectin of 0.1~0.5 weight % and 0.01~0.1 weight %
Element.Other schemes according to the present invention are containing lactoprotein, sodium, carbohydrate, the soybean polysaccharides of 0.2~1.2 weight %, 0.1
The insoluble fibrin of the threadiness of the HM pectin of~0.5 weight % and 0.01~0.1 weight % is as active ingredient
Acid moisture supplement agent.
So-called soybean polysaccharides, as long as including from the rhamnose of soybean, galactolipin, arabinose, xylose, grape
It is sugared, uronic acid one kind or two or more, among soybean, it is preferably derived from cotyledon.The molecule of the soybean polysaccharides of the present invention
Amount is not particularly limited, preferably high molecular molecular weight, preferably average molecular weight be it is thousands of~millions of, specifically 5
Thousand~1,000,000.In addition, the average molecular weight of the soybean polysaccharides is by with (the Showa electrician's strain formula meeting of standard pulullan polysaccharide
Society) as standard substance measure 0.1MNaNO3The value that the Intrinsic Viscosity Method of viscosity in solution is found out.Such soybean polyoses
Class can be commercially available, and can be used for example, SM-700 (three Rong Yuan エ Off エ Off ア イ societies systems) or SM-900 (three
Rong Yuan エ Off エ Off ア イ societies system).Structure of the soybean polysaccharides by its side chain is thought, to inhibit the junket egg in diet product
The mutual acid of albumin matter is solidified as reason, diet product separation and precipitation.
The concentration for the soybean polysaccharides that moisture supplement agent about the present invention is included, for example, in the water for making the present invention
Point supplement agent contains the insoluble fibrin of the threadiness of the HM pectin of 0.1~0.5 weight %, 0.01~0.1 weight %
In the case of, for example, 0.2~1.2 weight %, preferably 0.25~1.15 weight %, more preferably 0.3~1.1 weight %, into
One step is preferably 0.35~1.05 weight %, further preferably 0.4~1 weight %, further preferably 0.4~0.9 weight
Measure %, further preferably 0.4~0.6 weight %.The soybean polysaccharides that moisture supplement agent through the invention is included
Concentration is less than 1.2 weight %, to be preferred in terms of avoiding moisture supplement agent from feeling the unique flavor of soybean.In addition,
The concentration for the soybean polysaccharides that moisture supplement agent through the invention is included is higher than 0.2 weight %, to inhibit this hair
Also good aspect is preferred for the separation of bright moisture supplement agent and the generation of precipitation, further redispersibility.
So-called HM pectin is to be present in veterinary antibiotics, using α-D- galacturonic acids as master as cell wall constituent
The acidic polysaccharose class of chain ingredient.The galacturonic acid for constituting pectin is esterified by part methyl, and LM pectin is divided into according to esterification degree
With HM pectin.HM pectin generally refers to the ingredient that esterification degree is 50% or more.Such HM pectin can be commercially available, and be had
For example, SM-478 (three Rong Yuan エ Off エ Off ア イ societies systems), SM-666 (three Rong Yuan エ Off エ Off ア イ societies systems),
AYD5110SB (ユ ニ テ ッ ク フ ー ズ societies system) etc..It is negatively charged to think that HM pectin is characterized in, by with casein protein
In conjunction with, and in conjunction with casein protein repel each other because of charge, to prevent the mutual agglutination of casein protein.
The concentration for the HM pectin that moisture supplement agent about the present invention is included, in the moisture supplement agent for making the present invention
In the case of the insoluble fibrin of the threadiness of soybean polysaccharides containing 0.2~1.2 weight %, 0.01~0.1 weight %,
For example, 0.1~0.5 weight %, preferably 0.1~0.45 weight %, more preferably 0.1~0.4 weight %, further preferably
For 0.1~0.35 weight %, further preferably 0.1~0.3 weight %, further preferably 0.12~0.29 weight %, into
One step is preferably 0.14~0.28 weight %, further preferably 0.16~0.27 weight %, further preferably 0.18~
0.26 weight %, further preferably 0.2~0.25 weight %.The HM pectin that moisture supplement agent through the invention is included
Concentration be less than 0.5 weight %, even to containing casein containing hign concentration lactoprotein moisture supplement use
Agent also becomes low viscosity and is easy in terms of the form drunk be preferred.In addition, moisture supplement agent institute through the invention
Including HM pectin concentration be higher than 0.1 weight %, to inhibit moisture supplement agent separation and precipitation generation, into one
Walking redispersibility, also good aspect is preferred.
The insoluble fibrin of so-called threadiness is by making moisture supplement agent contain, so as in the diet product
The substance of middle structure tridimensional network, can improve the dispersibility of the insoluble compositions such as precipitation.About the insoluble of threadiness
Property cellulose, as long as inhibit the separation of moisture supplement agent and precipitation, redispersibility also good, what low viscosity and being easy to was drunk
Form, then there is no limit can use the insoluble fibre of the threadiness from plant and/or from microorganism in its source etc.
Dimension element.Insoluble fibrin from the threadiness of microorganism is, for example, the fermented cellulosic that will be generated by microorganism
Separating treatment is carried out from culture medium, is washed, appropriate substance refined and that threadiness is made.The insoluble fibre of the threadiness
Element is for example by micro- fibrillation until the fibrous insoluble fibrin of 0.01~0.1 μm of average diameter is (for example, referring to Japanese special
Open 2005-245217 bulletins) or fermented cellulosic.The insoluble fibrin of the threadiness of the present invention can be obtained commercially
, it can use for example, サ Application ア ー テ ィ ス ト PG (three Rong Yuan エ Off エ Off ア イ societies systems), サ Application ア ー テ ィ ス ト PN
(three Rong Yuan エ Off エ Off ア イ societies systems).
The concentration of the insoluble fibrin for the threadiness that moisture supplement agent about the present invention is included, makes the present invention
Moisture supplement agent contain the HM pectin of the soybean polysaccharides of 0.2~1.2 weight %, 0.1~0.5 weight % in the case of,
For example, 0.01~0.1 weight %, preferably 0.015~0.09 weight %, more preferably 0.02~0.08 weight %, further
Preferably 0.025~0.085 weight %, further preferably 0.03~0.07 weight %, further preferably 0.03~0.065
Weight %, further preferably 0.03~0.06 weight %, further preferably 0.03~0.055 weight %, further preferably
For 0.03~0.05 weight %.The concentration of the insoluble fibrin for the threadiness that moisture supplement agent through the invention is included
Less than 0.1 weight %, to no longer be low viscosity in the diet product for avoiding the lactoprotein containing casein containing hign concentration
And it is easy in terms of the form drunk be preferred.In addition, the threadiness that moisture supplement agent through the invention is included
The concentration of insoluble fibrin is higher than 0.01 weight %, in the separation and precipitation for avoiding to inhibit moisture supplement agent
Occur, further avoiding redispersibility, also no longer good aspect is preferred.
The moisture supplement agent of the present invention can include lipid.There is no limit as its original for the source of the lipid, form
Material, can enumerate for example, lactogenesis, full-cream concentrated milk, whole-fat milk powder, (fresh) cream, butter, vegetable fat, fish oil, lard, butter,
Medium chain triglyceride.Moreover, about " lipid ", become good aspect in the sweet taste from lipid, dense sense, as it
Raw material, preferably lactogenesis, full-cream concentrated milk, whole-fat milk powder, (fresh) cream, butter, that is, preferably butter oil.In addition, should " fat
Matter " can be used alone, and can also be mixed with two or more.Here, lipid content can for example be based on food composition table
It is calculated Deng well known information, furthermore, it is possible to be measured that by calculated by customary way." lipid " used in the present invention can make
With the raw material comprising lipid, diet product, for example, it is also possible to which it includes dairy milk starting material, dairy products from the lipid of breast to use.Or
Person, being somebody's turn to do " lipid " can use well known food additives in a manner of as desired concentration.
Moisture supplement about the present invention include lipid with agent in the case of the lipid content, as including specified amount
The mixture of moisture and in the case of adjusting, it is expected that every moisture supplement agent is 3.9 weight % or less.At this point, the water of the present invention
Even if point supplement agent plays the moisture supplementary result and/or water retention effect if not including lipid, but if including fat
Matter is then preferred in terms of it can assign from the dense sense of lipid.Therefore, preferred embodiment according to the present invention, at this
In the case that the moisture supplement of invention uses agent to be adjusted as the mixture comprising specified amount moisture, lipid content is preferably per moisture
Supplement agent is 0.3~3.9 weight %, more preferably 0.5~3.5 weight %, further preferably 0.8~3.0 weight %, spy
It You Xuanwei not 1.0~2.5 weight %, most preferably 1.2~2.0 weight %.
According to embodiment of the present invention, it is somebody's turn to do even if moisture supplement agent of the invention plays if not including lipid
Effect, thus can to need limit lipid intake the object such as object with lifestyle disease, disorders of lipid metabolism
Play effective water tariff collection effect.At this point, the moisture supplement of the present invention does not preferably include lipid with agent, but as its raw material
In the case of using dairy milk starting material, dairy products, it is difficult to remove lipid completely, therefore the moisture supplement of the present invention use agent as comprising
The mixture of specified amount moisture and in the case of adjusting, be at least 0.05 weight % or so with every moisture supplement agent include fat
Matter.Specifically, in the case where using dairy milk starting material, dairy products as raw material, the fat of the moisture supplement agent about the present invention
Matter content, in the case where being adjusted as the mixture comprising specified amount moisture, preferably per moisture supplement agent for 0.05~
3.7 weight %, more preferably 0.05~3.5 weight %, further preferably 0.05~3.0 weight %, further preferably
0.05~2.5 weight %, further preferably 0.05~2.0 weight %, further preferably 0.05~1.7 weight %, into one
Step is preferably 0.05~1.5 weight %, particularly preferably 0.05~1.3 weight %, most preferably 0.05~1.0 weight %.
Can include water, so-called water here, as long as the water of internal moisture in the moisture supplement agent of the present invention
, refer to the water simultaneously or separately absorbed with agent with the moisture supplement of the present invention, can enumerate for example, tap water, fossil water, well
Water, distilled water, pure water, carbonated water.Agent is being used to be adjusted as the mixture comprising specified amount moisture the moisture supplement of the present invention
, it is specified that it is 75.1~99.35 weight % that amount moisture, which is contemplated to be every moisture supplement agent, in the case of whole.
About the moisture supplement agent of the present invention, as long as playing the effect, so that it may by be comprising in the form of specified amount moisture,
Or the form (liquid form) of the mixture of the moisture as the amount comprising discontented specified amount moisture, can also be specified amount moisture
The form (dry-form) being substantially removed may be used for example, solid-like (powdered, graininess, capsule shape, bulk
Deng), liquid, gel, paste, the forms such as pulpous state.The moisture supplement agent of the present invention can make water in the case of solid-like
It separates, therefore keeping quality, portability can be improved, even if being liquid, also there is heat-resisting effect as described later and process
Adaptability is good, as a result, it may be said that keeping quality is high.
A scheme according to the present invention, moisture supplement of the invention agent it is expected to become 0.07g or more/kg with each meal
The mode of weight is ingested, preferably to become 0.1~4.4g/kg, more preferably to become 0.2~2.7g/kg, further preferably with
As 0.2~1.8g/kg, particularly preferably it is ingested in a manner of as 0.2~0.9g/kg.Here, the representative weight of object
It is estimated as 60kg.It, can be in addition, the moisture supplement of the present invention uses agent as the mixture comprising moisture and in the case of modulate
Intake is eaten for example as 200~1000ml with one, and the mode for preferably becoming 400~1000ml suitably adjusts moisture.
Other schemes according to the present invention, for example, unit packaging form of the moisture supplement agent of the present invention by each meal
It constitutes, includes lactoprotein, sodium, carbohydrate and stabilizer in the unit packaging form, as a meal intake, such as be adjusted to
1~26g as other schemes, is preferably regulated as 2~16g, is more preferably adjusted to 2~13g, into one it is expected that being adjusted to 4~26g
Step is preferably regulated as 2~11g.Here, so-called to be made of " the unit packaging form of each meal ", it is taking the photograph for prespecified each meal
The form of taken amount refers not only to normal food for example, as the diet product for capableing of orally ingestible specific quantity, and refers to beverage
The forms such as (drink agent etc.), healthy accesary foods, health functional food, replenishers.In the beverage, gel, paste of such as liquid
Shape or pulpous state freeze shape, powdered, graininess, capsule shape or block-like solid-like food etc. in the case of, " the list of each meal
Position packaged configuration ", which can be enumerated, can use metal can, vial (bottle etc.), plastic containers (PET bottle etc.), packaging bag (pack), draw
The packing containers such as line bag (pouch), film container, carton carry out the form of regulation specific quantity (dosage) or by taking the photograph each meal
Taken amount (usage, dosage) is shown in the form that packing container, homepage etc. carry out regulation specific quantity.In addition, the moisture supplement of the present invention
Use agent as the mixture comprising moisture and in the case of modulate, the intake that can be eaten with one for example as 200~
1000ml, the mode for preferably becoming 400~1000ml suitably adjust moisture.
Other schemes according to the present invention, for example, the moisture supplement agent of the present invention is so-called healthy beverage in its form
In the case of, the beverage of " lactoprotein, sodium, carbohydrate and stabilizer " for suspending or having dissolved 4~26g can be enumerated with each food and drink
Complete capacity (dosage) meter is adjusted as the mode of 200~1000ml with moisture, is packed into (filling) and is arrived such as metal can, glass
The form of bottle (bottle etc.), plastic containers (PET bottle etc.) packing container.Or suspend or dissolved 4~26g " lactoprotein,
The beverage of sodium, carbohydrate and stabilizer ", which can be enumerated, is shown in each meal intake (usage, dosage) (for example, 200~1000ml)
Packing container, homepage etc. will count meal part (part for several times) and summarize capacity together, be encased in packing container of large capacity etc.
Form.
About the moisture supplement agent of the present invention, as long as being manufactured in a manner of comprising predetermined component, then its manufacturing process (makes
Make step) there is no limit based on the manufacturing process of cow's milk, composition adjustment cow's milk, modified milk, milk beverage etc. for example, can be made
It makes.The moisture supplement agent of the present invention for example can by according to well known manufacturing method (manufacturing technology), to lactogenesis (former breast),
Breast, concentrated milk, milk powder, recombined milk are sterilized, coordinates the various compositions such as (adjustment) lactoprotein, butter oil to manufacture, alternatively, also may be used
With by composition adjustment cow's milk, modified milk (low fat breast, fat-free breast etc.), cooperation (adjustment) lactoprotein, butter oil etc.
Various composition manufactures.
The heat resistance (thermal stability) of the moisture supplement agent of the present invention is high, plays heat-resisting effect.Here, so-called performance is resistance to
Thermal effect, refer to even if not curing (agglutination) because of thermal denaturation if specific temperature is handled protein, it is specific and
Speech, refers to not thermal change if condition, the method used in the general working process using cow's milk carries out heating sterilization protein
Property.That is, so-called performance heat-resisting effect, more specifically the moisture supplement agent for the present invention refers to even if at 62~65 DEG C
Heating sterilization (LTLT processing was carried out with 30 minutes:Low temperature long-time heating), alternatively, as with it is more than its equal extent
The method of bactericidal effect, for example, carrying out heating sterilization (UHT processing at 120~150 DEG C with 1~30 second:Superhigh temperature heats), or
At 72 DEG C or more heating sterilization (HTST processing was carried out with 15 seconds or more:Heated between high temperature, short time), or at 75 DEG C or more with 15 points
Heating sterilization etc. more than clock is carried out, protein is not easy to thermal denaturation.At this point, plus in thermally-sterilized method, can use:Use tank
Deng carry out while being stirred treatment fluid heating holding it is intermittent, used heat-exchangers of the plate type, tubular heat exchange
The indirect heating manner of device has used steam-injection-type heating device, steam impregnated heating device directly heat mode, use
Method well known to electrified regulation mode of Joule heating device etc. etc..
The moisture supplement of the present invention plays heat-resisting effect with agent.Therefore, for cooperation (the addition, mixing) water of the present invention
The composition for dividing supplement agent can preferably be used as liquid since the moisture supplement agent of the present invention plays heat-resisting effect
Product form and provide, and can be as the system for having used the heating of hot Vending Machine (hot vendor) etc. to peddle
Product form and provide.
In addition, the form of the composition about cooperation (addition, mixing) moisture supplement agent of the invention, as long as playing
The effect, so that it may using be as comprising the present invention moisture supplement use agent specified amount moisture mixture in the form of or as
The form (liquid form) for including the mixture of the moisture of the amount of discontented specified amount moisture, can also be that specified amount moisture is substantial
The form (dry-form) being removed, may be used for example, solid-like (powdered, graininess, capsule shape, bulk etc.), liquid,
The form of gel, paste, pulpous state etc..It is discontented with specified amount moisture in the moisture that the moisture supplement agent of the cooperation present invention is included
Substance or the present invention moisture supplement the case where providing composition with the substance that the moisture that agent is included substantially is removed
Under, when absorbing or granting the composition of the present invention, it is expected that simultaneously or separately absorbing or applying necessary amount moisture with the composition
With.
Other schemes according to the present invention, provide contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and
For the acid newborn diet product of moisture supplement.The moisture supplement of the present invention can be moisture supplement diet product with newborn diet product
Composition.In addition, moisture supplement is preferably the newborn diet product of moisture supplement holding with newborn diet product.The diet product of the present invention and sheet
The moisture supplement agent of invention is likewise it is possible to using solid-like (powdered, graininess, capsule shape, bulk etc.), liquid, coagulate
The form of glue, paste, pulpous state etc..The newborn diet product of moisture supplement includes that display is fast based on absorption of the moisture into organism
The effect of the effect of characteristic or absorption based on from moisture to organism is fast and moisture is kept for a long time in vivo characteristic
Diet product.
The diet product of the so-called present invention refers to the diet product comprising breast and/or dairy products.Here, so-called breast is such as ox
Breast, sheep breast, goat dairy, buffalo's milk, sheep breast, bactrian camel milk, whale breast, dolphin breast, human milk etc. derive from the breast etc. of mammal.This
Outside, here, so-called dairy products are the products processed to breast, can both use the raw material such as degreasing of well known liquid
Breast, partly skimmed milk, desalination skimmed milk, desalination breast, composition adjustment breast, whey, concentrated milk, skim concentrated milk, partially skimmed are dense
Contract breast, desalination skim concentrated milk, condensed milk, cream, by known method modulate from dairy milk starting material penetrant, pass through known in
The lactoprotein concentrate etc. of method modulation, can also use the well known raw material processed such as milk powder, butter, concentration
Breast, condensed milk, lactose, Whey Mineral etc..
Also include healthy food, functional food, dietary supplement, specific health care in addition, in the diet product of the present invention
Use the adjustment milk powder that food, newborn child that food, patient uses uses, the milk powder that pregnant and lying-in women use or lactication woman uses or enclose as
Lasting water tariff collection and the such substance classified of diet product of the declaration of will of substance used.
The newborn diet product of the present invention is preferably milk beverage.
PH value, lactoprotein, the concentration of lactoprotein, the concentration of sodium, the stabilizer of newborn diet product etc. about the present invention,
It can be identical as the moisture supplement agent of the present invention.In addition, the manufacturing method of the diet product as the present invention, it can also be with this hair
Bright moisture supplement agent is identical.
In addition, the moisture supplement agent of the present invention can be " drug " (pharmaceutical composition).That is, according to the present invention other
Scheme provides and contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and for acid moisture supplement (or moisture
Supplement keeps using) drug (pharmaceutical composition).So-called " drug " (pharmaceutical composition), be in order to formulation and being used in combination can allow
Additive, conventionally, the substance modulated as oral preparation or non-oral formulation.It is oral preparation in drug
In the case of, the solid pharmaceutical preparations such as tablet, powder, granula subtilis, granule, capsule, pill, sustained release agent, solution, suspension may be used
The form of the liquids preparation such as liquid, emulsion.In addition, from the aspect of the simplification of the intake (granting) to patient, drug is preferred
For oral preparation.Here, it for the additive that can be allowed in order to formulation, can enumerate for example, excipient, stabilizer, anti-
Rotten agent, wetting agent, emulsifier, lubricant, sweetening material, colorant, fragrance, buffer, antioxidant, pH adjusting agent etc..About
The drug (pharmaceutical composition) of the present invention, as long as requiring supplementation with or keeping the disease of moisture, then any disease can be applicable in,
It can be used for the treatment or prevention of such as exsiccosis, heatstroke.In addition, the drug (pharmaceutical composition) of the present invention can be used for
Cause is in internal hydropenic disease, for example, constipation, hypertension, artery sclerosis, thrombosis, cerebral infarction, myocardial infarction, gout, cancer
Deng treatment or prevention.
Other schemes according to the present invention, provide the application of diet product or drug, be diet product for keeping the skin wet or
The application of drug, above-mentioned diet product or drug contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and are acid
Property.
Other preferred embodiments according to the present invention, provide the application of diet product or drug, are for keeping the skin wet and keeping
The diet product of moisture or the application of drug, above-mentioned diet product or drug contain lactoprotein, sodium, carbohydrate and stabilizer as effective
Ingredient, and be acidity.
Preferred other schemes according to the present invention, provide the application of diet product or drug, are for in being not easy pair
It keeps the skin wet in vivo and/or keeps the environment of moisture and/or the object of state in vivo, supplement and/or keep the diet of moisture
The application of product or drug, above-mentioned diet product or drug contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and
For acidity.
Other schemes according to the present invention, provide contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and
For application of the acid moisture supplement agent in manufacturing diet product or the drug for keeping the skin wet.
Other preferred embodiments according to the present invention, provide contain lactoprotein, sodium, carbohydrate and stabilizer as effectively at
Divide and is application of the moisture supplement agent of acidity in manufacturing diet product or the drug for keeping the skin wet and keeping moisture.
Preferred other schemes according to the present invention, provide contain lactoprotein, sodium, carbohydrate and stabilizer as effectively at
Point and for acid moisture supplement agent manufacture for in the environment being not easy to supplementing and/or keeping moisture in vivo and/
Or state object supplement and/or keep moisture diet product or the application in drug.
Other schemes according to the present invention, provide the application of diet product or drug, for keeping the skin wet, above-mentioned diet product or
Drug contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and is acidity.
Other schemes according to the present invention, provide the application of diet product or drug, for keeping the skin wet, and keep water
Point, above-mentioned diet product or drug contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and are acidity.
Other schemes according to the present invention provide diet product or drug for keeping the skin wet, above-mentioned diet product or drug
Contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and is acidity.
Other schemes according to the present invention provide diet product or drug for keeping the skin wet and keeping moisture, above-mentioned drink
Food or drug contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and are acidity.
Other schemes according to the present invention, provide moisture compensation process, it includes following step:Make the object intake present invention
The agent of moisture supplement or the newborn diet product of moisture supplement.The object can be in be not easy to keep the skin wet in vivo and/or
The environment of moisture and/or the object of state are kept in vivo.
Other preferred embodiments according to the present invention provide moisture compensation process (except the medical act of people), it includes
Following step:Make the agent of moisture supplement or the newborn diet product of moisture supplement of the object intake present invention.Here, so-called " to people's
Medical act " refers to the prescription for needing doctor etc., makes one the behavior etc. of intake (granting) drug.The water tariff collection side of the present invention
Method can be implemented about the water tariff collection agent of the present invention according to the content recorded in present specification.
Other schemes according to the present invention provide prevention and/or the therapy of exsiccosis or heatstroke, and it includes following steps
Suddenly:Make in be not easy the object to the environment and/or state that keep the skin wet and/or keeps moisture in vivo, be preferably People or
Children according to circumstances simultaneously or separately absorb the moisture supplement agent of the present invention with water.Preferred embodiment according to the present invention, dehydration
The prevention and/or therapy of disease or heatstroke are the methods other than the medical act to people.The present invention exsiccosis or in
The prevention of heat and/or therapy can be according in recorded in present specifications about the water tariff collection method of the present invention
Hold to implement.
Other schemes according to the present invention provide the treatment use or prevention diet product (diet product group of exsiccosis or heatstroke
Close object) or drug (pharmaceutical composition), contain lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and be acid
Property.
Embodiment
Hereinafter, enumerating embodiment, illustrate the present invention in further detail, but the present invention is not limited thereto.In addition, about this
The assay method and unit of invention are recorded as long as no special, then according to the regulation of Japanese Industrial Specifications (JIS).
[Test example 1]
The modulation of the milk beverage of the present invention
By lactoprotein concentrate (lactoprotein 80 weight %, 6.5 weight % of lactose) 4.35kg dissolve by heating in
The water of 40.65kg, is made solution A.By soybean polysaccharides 0.45kg, HM pectin 0.2kg, fermented cellulosic 0.05kg, trehalose
1kg, granulated sugar 3.3kg, Sucralose 0.0063kg heat the water for being dissolved in 39.99kg, and solution B is made.By citric acid 0.64kg
It is dissolved in the water of 9.36kg, solution C is made.After solution A is mixed with solution B, by solution C point while stirring the mixed liquor
It was added through 5 minutes at 10 times, the elementary mixing material before sterilization is made.The elementary mixing material is subjected to 15MPa with board-like sterilization machine
Homogenize process (70~80 DEG C) after, carried out at 130 DEG C 2 seconds sterilization after, be cooled to 10 DEG C hereinafter, as the present invention
Milk beverage (3.5 weight % of lactoprotein, 0.45 weight %, HM pectin of soybean polysaccharides, 0.2 weight %, fermented cellulosic
0.05 weight %, 1 weight % of trehalose), it is used in test example 1 and 2 below.The pH value of the milk beverage of the present invention is 4.1,
Viscosity is 10mPas (10 DEG C)." entrance taste ", " precipitation ", " redispersibility " are all good.In addition, lactoprotein used herein
Matter concentrate is that skimmed milk is carried out membrane separation (UF processing, MF processing etc.), lactose, ash content is removed, with casein
The mixture of casein protein and whey protein obtained by matter and whey protein are concentrated as main body, form are drying
Powder.Moreover, the albumen quality ratio of lactoprotein concentrate, in the same manner as lactogenesis (cow's milk), casein protein:Lactalbumin
Matter=about 8:2 (with reference to the strong lucky volume of Shan Nei nation men and Hengshan Mountain, ミ Le Network Gross closes dictionary).
The measurement of plasma volume change rate
The male SD rat (Japanese Network レ ア societies system) of 9 week old is bought, be accustomed to 1 week or more.Rat is set to carry out 20 hours
Fasting and 4 hours taboo water.Then, distilled water, sports drink as experiment beverage are granted so that 20mL/kg is oral to the rat
(ポカリスエット:Otsuka Pharmaceutical Co., Ltd's system), cow's milk (Mingzhi's cow's milk:Meiji KK's system) or above-mentioned modulation sheet
The milk beverage (agent of moisture supplement) of invention.Before oral grant (0 minute) and grant 15 minutes afterwards, 30 minutes, 60 minutes,
Local blood sampling is carried out by jugular vein under isoflurane anesthesia after 120 minutes and 180 minutes, with Hemalog XT-
1800iV (シ ス メ ッ Network ス Co. Ltd. systems) determines hematocrite value and blood hemoglobin concentration.By haemocyte ratio
Capacitance and hemoglobin concentration find out plasma volume change rate (%).By the milk beverage of the sports drink granted, cow's milk and the present invention
Composition be shown in following table 1.Each group uses each 8.
[Table 1]
Table 1:Test the composition of beverage
| Sports drink※ | Cow's milk | The milk beverage of the present invention | |
| Energy (kcal) | 25 | 69 | 23 |
| Lactoprotein (weight %) | 0 | 3.4 | 3.5 |
| Lipid (weight %) | 0 | 3.9 | 0.0 |
| Carbohydrate (weight %) | 6.2 | 5.0 | 2.3 |
| Sodium (weight %) | 0.049 | 0.043 | 0.018 |
※Stabilizer is free of in sports drink, the carbohydrate that sports drink is included is granulated sugar and pyroglutamate liquid sugar, movement
The pH value of beverage is 4.2.
The result of plasma volume change rate
It is shown in Figure 1 that each beverage is taken orally into the plasma volume change rate after granting.The present invention milk beverage and sports drink with
Plasma volume after cow's milk is compared 15 minutes shows significant high level.Known to the present invention milk beverage compared with cow's milk, moisture is to body
Interior intake is fast.In addition, the present invention milk beverage plasma volume change rate compared with sports drink, at 15 minutes, 30 minutes, 60 points
Any moment behind clock, 120 minutes and 180 minutes all exceeds.
[Test example 2]
The male SD rat (Japanese Network レ ア societies system) of 9 week old is bought, is accustomed to 1 week.The fasting for making rat carry out 20 hours
With 4 hours taboo water.Distilled water, sports drink (Port カ リ ス エ ッ ト are granted so that 20mL/kg is oral:Otsuka Pharmaceutical Co., Ltd
System), cow's milk (Mingzhi's cow's milk:Meiji KK's system) or above-mentioned test example 1 in modulate the present invention milk beverage, by rat
It is transferred in the cage of urine collection, measures urinary excretion after 4 hours.Each group uses each 7.
The result of accumulated urinary excretion amount
Accumulated urinary excretion amount after each beverage is granted is shown in Figure 2.The present invention milk beverage after 90 min with movement
Compared to significant low value (p < 0.05) is shown, (statistical method is carried out beverage using Tukey-kramer inspections.It is also the same below).
In addition, the milk beverage of the present invention shows significant low value (p < 0.05) after 60~240 minutes compared with distilled water.The present invention
Milk beverage compared with sports drink and distilled water, accumulated urinary excretion amount show low value.In addition it is found that the present invention milk beverage with
The accumulated urinary excretion amount of cow's milk is equal extent.
It can be seen from the above result that milk beverage (moisture supplements agent) of the invention is compared with cow's milk, moisture is rapidly to biology
Body absorption makes plasma volume increase rapidly.In addition it confirms, the water tariff collection effect of milk beverage of the invention (agent of moisture supplement)
Fruit is higher than sports drink, is almost equal extent with cow's milk.In addition it is found that the milk beverage (agent of moisture supplement) of the present invention has
, moisture more excellent than sports drink is to the fast characteristic of biological body absorption.It is further known that milk beverage of the invention (is mended by moisture
Fill and use agent) also together with water retention effect excellent possessed by cow's milk, and understand to become and have cow's milk and movement concurrently
The moisture of beverage advantage, more effective fruit supplements holding agent.
In addition it confirms, not only moisture absorption, water tariff collection are good, but also lactoprotein is used as amino acid into blood plasma
Absorption it is also good.Moisture supplements and Protein intake carries out rapidly, therefore also confirms especially taking the photograph after exercise together
It is useful in taking.
Claims (13)
1. a kind of moisture supplement agent contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and is acidity.
2. moisture supplement agent according to claim 1 is used to supplement holding moisture.
3. moisture supplement agent according to claim 1 or 2, a concentration of 2~7 weight % of lactoprotein.
4. moisture supplement agent described in any one of claim 1 to 3, na concn is 0.005~0.1 weight %.
5. moisture supplement agent according to any one of claims 1 to 4, concentration of saccharide is 0.1~10 weight %.
6. moisture supplement agent according to any one of claims 1 to 5, carbohydrate includes selected from trehalose, sucrose, different wheat
One or more of bud ketose, maltose, lactose, glucose and dextrin.
7. according to moisture supplement agent according to any one of claims 1 to 6, stabilizer contains the big of 0.2~1.2 mass %
The insoluble fibrin of the threadiness of beans polysaccharide, the HM pectin of 0.1~0.5 mass % and 0.01~0.1 mass %.
8. the pH value of moisture supplement agent according to any one of claims 1 to 7, moisture supplement agent is 3~6.
9. a kind of newborn diet product of moisture supplement, contains lactoprotein, sodium, carbohydrate and stabilizer as active ingredient, and
For acidity.
10. the newborn diet product of moisture supplement according to claim 9, is milk beverage.
11. a kind of moisture compensation process, it includes make object absorb moisture supplement according to any one of claims 1 to 8 to use
The newborn diet product of moisture supplement described in agent or claim 9 or 10.
12. containing lactoprotein, sodium, carbohydrate and stabilizer as active ingredient and being used in manufacture for acid moisture supplement agent
Application in the diet product or drug to keep the skin wet.
13. a kind of diet product or drug for keeping the skin wet contains lactoprotein, sodium, carbohydrate and stabilizer as effective
Ingredient, and be acidity.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016032302 | 2016-02-23 | ||
| JP2016-032302 | 2016-02-23 | ||
| PCT/JP2017/006803 WO2017146141A1 (en) | 2016-02-23 | 2017-02-23 | Rehydration agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108697125A true CN108697125A (en) | 2018-10-23 |
Family
ID=59685247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780011727.1A Pending CN108697125A (en) | 2016-02-23 | 2017-02-23 | Moisture supplement agent |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6961569B2 (en) |
| CN (1) | CN108697125A (en) |
| WO (1) | WO2017146141A1 (en) |
Families Citing this family (1)
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|---|---|---|---|---|
| JP7022449B2 (en) * | 2020-07-15 | 2022-02-18 | 大洋香料株式会社 | Compositions for dairy protein dispersion, concentrates for dairy alcoholic beverages, and dairy alcoholic beverages |
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Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2017146141A1 (en) | 2018-12-13 |
| JP6961569B2 (en) | 2021-11-05 |
| WO2017146141A1 (en) | 2017-08-31 |
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