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CN108669540A - Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof - Google Patents

Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN108669540A
CN108669540A CN201810445031.6A CN201810445031A CN108669540A CN 108669540 A CN108669540 A CN 108669540A CN 201810445031 A CN201810445031 A CN 201810445031A CN 108669540 A CN108669540 A CN 108669540A
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parts
cerebral apoplexy
powder
protein
clinical nutrition
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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Priority to CN201810445031.6A priority Critical patent/CN108669540A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
    • A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A23L13/50—Poultry products, e.g. poultry sausages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/10—Fish meal or powder; Granules, agglomerates or flakes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A23L7/198—Dry unshaped finely divided cereal products, not provided for in groups A23L7/117 - A23L7/196 and A23L29/00, e.g. meal, flour, powder, dried cereal creams or extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of cerebral apoplexy tailored version clinical nutrition formula, including following component and its parts by weight：11 20 parts of protein, 10 12 parts of fat, 55 60 parts of carbohydrate, 69 parts of dietary fibers, 0.6 1.2 parts of macroelements, 0.01 0.04 parts of trace elements, 0.005 0.03 parts of liposoluble vitamins, 0.008 0.2 parts of water soluble vitamins, 0.01 1 parts of diet essence, 0.05 1 parts of integration of drinking and medicinal herbs ingredients, 0.02 3 parts of natural plants compounds and 0.05 2 parts of new resource foods；The present invention also provides the preparation methods of above-mentioned clinical nutrition formula.The clinical nutrition formula of the present invention can either meet the nutritional need of patients with cerebral apoplexy general equilibrium, and the incidence rate that can be improved patient body quality, improve immunocompetence, alleviate cerebral apoplexy symptom, mitigate patient's slight illness, reducing patients with cerebral apoplexy.

Description

Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to nutrient formulation field more particularly to a kind of cerebral apoplexy tailored version clinical nutrition formula and its preparation sides Method.
Background technology
Acute apoplexy is a kind of acute cerebrovascular lesion that clinic is common, and onset is anxious, and the death rate is high, seriously threatens people Health.Cerebral apoplexy easily causes patient's aphetite disorder, and cough of choking can not be fed, and some patients with cerebral apoplexy appetite is indifferently very To food refusal；What case above all directly affected patients with cerebral apoplexy nutritional ingredient takes the photograph people and absorption, to cause patient malnutritive, Immunity of organisms is low, easily induces pulmonary infection and aggravates disease.
Patients with cerebral apoplexy dystrophia is very universal, and correlative study shows that the malnourished incidence of acute stroke patients is 9%, the death rate of subalimentation patient is 37%, this result of study show patients with cerebral apoplexy merge subalimentation be cause it is bad The independent hazard factor of final result also has research to confirm malnutritive significantly correlated with the badness come-off of cerebral apoplexy.Therefore, how root It is particularly important according to the state of an illness of Severe Stroke Patients, the rational individuation nutritional support scheme of nutrition condition formulation.
It cannot be fed due to patients with cerebral apoplexy generally existing dysphagia obstacle, it should be after cerebral apoplexy generation in early days Early stage rational nutritional support is carried out to patient, patient is can aid in and energy is replenished in time, builds up health, contribute to patient extensive It is multiple.
Cerebral arterial thrombosis merges the disturbance of consciousness patient overwhelming majority there are autonomous dysphagia, in addition disease itself and Caused Systemic stress response, metabolic rate significantly increase during treatment, will be notable if failing to provide nutritional support in time at this time The treatment for influencing patient disease causes the malnutritive even disability rate of patient and case fatality rate to increase.Previous research confirms that body is sought It is the prognosis mala final result even raised independent hazard factor of case fatality rate in 30d after the onset of ischemic cerebral stroke patients to support bad.
With the exacerbation of aging of population, the incidence of ischemic stroke in aged patients constantly rises.Cerebral arterial thrombosis is suffered from Person's body is in the hypermetabolism state of irritability, and patient is hyperfunction to the decomposition of energy matter, and the wherein decomposition of protein is more than it Easily there is Hypoproteinemia and hyperglycemia in synthesis, patient, the shortage of old patients with stroke nutriment especially protein, The maintenance of elderly population muscular strength, immunity etc. can be influenced, therefore the good protein that is easy to digest and assimilate and utilize is replenished in time It is the important link in ischemic stroke in aged patients patient treatment.
Patients with Post Stroke body metabolism is accelerated, and negative nitrogen balance occurs, Hypoproteinemia, body's immunity by Inhibit, be easy to happen multiple infection, directly or indirectly influences the recovery of Post stroke nervous function and vital function.Traditional viewpoint It is advocate that early stage applies parenteral nutrition more, it is transitioned into enteral nutrition again after 7~10d.With the eighties in last century to gut function again Understanding, especially gut muco-membranous barrier, bacterial reproduction move up and the establishment of the concepts such as enteron aisle stress reaction, the morning of critical patient Phase enteral nutrition is clinically increasingly taken seriously, and has scholar to think, the time that nutritional support starts and patient's protopathy Severe degree is unrelated.Therefore, for the fine patient of gastrointestinal function, to make full use of the function of gastrointestinal tract, promote nutrition at The absorption divided improves the malnutritive situation that patient has occurred or will occur, corrects internal negative nitrogen balance and metabolism, Enhance Abwehrkraft des Koepers, effectively prevents the generation of complication.Current clinically used nutritional support be divided into enteral nutrition with completely Parenteral alimentation and the two combine, and preferred early enteral nutrition is supported if conditions permit, and for merging gastrointestinal function Obstacle person then implements Parenteral nutrition under proper intensive care and transits to enteral nutrition or partial enteral nutrition as early as possible simultaneously. And the enteral nutrition preparation for being directed to patients with cerebral apoplexy currently on the market is fewer and fewer, therefore cerebral apoplexy enteral battalion should be researched and developed as early as possible Support the corresponding product of preparation.
A kind of total nutrient preparation for patients with cerebral apoplexy disclosed in Chinese patent CN104286841A uses rice flour, meals Fiber, maltodextrin, plant fat, compound protein, oligopeptide, minerals, vitamins and other nutritious components are eaten to supplement cerebral apoplexy The nutritional need of patient, but its only by the proportioning between adjusting various basal nutrient components to eliminate each component itself For obstacle to improve the nutrient balance of each component, there is no attempt further to alleviate cerebral apoplexy trouble by adding special nutrient compositions The various symptoms of person, to promote the nutrient absorption of patient, reduce the generation of cerebral apoplexy.
Therefore, the nutritional need of patients with cerebral apoplexy general equilibrium can either be met by developing, and can improve patient body matter Amount, raising immunocompetence, alleviation cerebral apoplexy symptom, mitigation patient slight illness, the enteral for the incidence rate for reducing patients with cerebral apoplexy are sought Preparation is supported, there is important value and wide market.
Invention content
The purpose of the present invention is to overcome the defects in the prior art, provides a kind of cerebral apoplexy tailored version clinical nutrition formula And preparation method thereof, the nutritional need of patients with cerebral apoplexy general equilibrium can either be met, and patient body quality can be improved, carried High immunocompetence, the incidence rate alleviating cerebral apoplexy symptom, mitigate patient's slight illness, reducing patients with cerebral apoplexy.
To achieve the above object, the present invention adopts the following technical scheme that：
The first purpose of the invention is to provide a kind of cerebral apoplexy tailored version clinical nutrition formula, including following component and its Parts by weight：11-20 parts of protein, 10-12 parts of fat, 55-60 parts of carbohydrate, 6-9 parts of dietary fibers, 0.6-1.2 parts Macroelement, 0.01-0.04 parts of trace elements, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamin lifes Element, 0.01-1 parts of diet essence, 0.05-1 parts of integration of drinking and medicinal herbs ingredients, 0.02-3 parts of natural plants compounds and 0.05-2 parts are new Resource food；
Wherein, the integration of drinking and medicinal herbs ingredient include lophatherum gracile, Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn, mulberry leaf, oyster, At least one of Radix Glycyrrhizae；
Wherein, the new resource food includes first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, the leaf of bamboo Flavones, casein phosphopeptide, avenabeta glucosan, dragon protein, peony seed oil, yeast beta-dextran, newborn mineral salt, maca At least one of powder, Rosa roxburghii Tratt, xylo-oligosaccharide.
In order to advanced optimize above-mentioned technical proposal, the technical measures that the present invention is taken further include：
Further, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 10~15：25~ 30：50~60；Further, protein：Fat：The productivity ratio of carbohydrate is 13：27：60.
Further, the protein includes PURE WHEY, soybean protein isolate, hydrolysis Isin glue collagen, whole milk At least one of powder, skimmed milk power, dried whole-egg, lactoferrin, colostrum, amino acid and protein peptides；The amino acid includes L-lysine-Pidolidone, Pidolidone, L-arginine, L-Trp, L-Glutamine, taurine, Valine, L- are different At least one of leucine, L-Leu；The protein peptides include soybean oligopeptide, wheat protein peptide, pupa albumen peptide, sea At least one of foreign fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide.
Further, the ratio that the taurine provided in the protein accounts for gross protein weight is 0.5%-2%.
Further, the protein exists according to the amount for giving patient 1.5-1.8g/kg；Further, the egg White matter exists according to the amount for giving patient 1.6g/kg.
Further, the protein includes 5-8 parts of lactalbumin；Further, the protein includes 5-6 parts Lactalbumin；Further, the protein includes 5.5 parts of lactalbumin.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide.
Further, the fat includes medium chain triglyceride, olive oil, soybean oil, coconut oil, perilla herb oil；More into one Step, in the fat, the ratio that medium chain triglyceride accounts for total fat weight is 2%-5%.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch In at least two；Further, the carbohydrate is maltodextrin and tapioca.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.
Further, the macroelement includes calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium gluconate, citric acid At least one of potassium, potassium chloride, K-IAO, sodium chloride, sodium citrate and magnesium gluconate, magnesium carbonate, magnesium sulfate.
Further, the trace element includes ferrous gluconate, ferrous sulfate, potassium iodide, zinc citrate, glucose In sour zinc, sodium selenite, copper sulphate, copper gluconate, chromium sulfate, chromium chloride, manganese gluconate, manganese sulfate, sodium molybdate extremely Few one kind.
Further, the liposoluble vitamin includes vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of；Further, the liposoluble vitamin is vitamin A, beta carotene, vitamin D3, dimension life Plain E.
Further, the water soluble vitamin includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin；Further, the water soluble vitamin is Vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenic acid, folic acid, niacin；Wherein, folic acid accounts for total water solubility The ratio of vitamin weight is 0.05%-0.1%, and the ratio that niacin accounts for total water soluble vitamin weight is 6.5%-7%.
Further, the diet essence includes cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein, the cereal include rice meal, millet powder, black rice flour, coixlacrymajobi powder, At least one of corn flour, wheat germ powder, oatmeal, buckwheat；The beans include peameal, mung bean flour, black bean powder, At least one of red bean powder, soy meal；The potato is mainly made of common yam rhizome powder；The greengrocery includes carrot meal, white trailing plants At least one of Bu Fen, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae includes mushroom powder, sea At least one of band powder, white fungus powder；The nut-seed class is mainly made of pumpkin seed powder and lotus nut starch；The fish and shrimp packet Include at least one of salmon powder and cod meal；The poultry meat includes at least one in chicken meal, powdered beef, pig kidney powder Kind；The fruits include at least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder.
Further, the parts by weight of the integration of drinking and medicinal herbs ingredient are 0.07-0.28 parts.
Further, the integration of drinking and medicinal herbs is at including for lophatherum gracile, Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn and mulberry leaf； Further, each component and its parts by weight are as follows in the integration of drinking and medicinal herbs ingredient：0.01-0.4 parts of lophatherum gracile, Poria cocos 0.01-0.4 parts, 0.01-0.4 parts of cape jasmine, 0.01-0.4 parts of honeysuckle, 0.01-0.4 parts of pueraria lobata, 0.01-0.4 parts of sea-buckthorn, mulberry leaf 0.01-0.4 parts.
Further, the natural plants compound includes l-cn, Glucosamine, oligofructose, lutein, plant At least one of object sterol, lycopene, resveratrol, allicin；Further, the natural plants compound is a left side Revolve carnitine.
Further, the parts by weight of the new resource food are 0.02-0.06 parts.
Further, the new resource food includes ground dragon protein and peony seed oil；Further, described ground dragon protein Parts by weight with peony seed oil are：Dragon protein 0.01-0.1 parts of ground, 0.01-0.1 parts of peony seed oil；Further, described The parts by weight of ground dragon protein and peony seed oil are：Dragon protein 0.01-0.02 parts of ground, 0.01-0.02 parts of peony seed oil.
Further, the cerebral apoplexy tailored version clinical nutrition formula also comprises the following components and the Chinese medicine of parts by weight： 0-0.1 parts of Rhizoma Chuanxiong, 0-0.1 parts of Fructus Corni, 0-0.1 parts of winter creeper, 0-0.1 parts of Radix Angelicae Sinensis, 0-0.1 parts of Radix Notoginseng.
Second object of the present invention is to provide a kind of preparation method of above-mentioned cerebral apoplexy tailored version clinical nutrition formula, packet Include following steps：
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, it will The raw material of crushing is placed in container, and 3~8 times of the water that weight is raw material weight is added, impregnates 3~4 hours, then to soak 30~60min is decocted, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved and prepared with 60~80 mesh Integration of drinking and medicinal herbs component powders；
Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the fat-soluble dimension of predetermined weight number Raw element is used as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous under high pressure Time is 10~15min, then carries out instantaneous drying of spraying, liposoluble vitamin powder is prepared with 60~80 mesh screenings；It will be pre- The water soluble vitamin of parts by weight is determined as core material, is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, sprays wink When dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 4, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, diet essence China, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 5, the powder obtained by step 1~4 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, passed through It is spare after sterilization processing；
Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution At least one of；
Wherein, the sequence of step 1~4 can be replaced mutually.
Further, fat powder is prepared in the step 1 to specifically comprise the following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 10g, soybean protein isolate 4g, skimmed milk powder 11g, dietary fiber 2g (resistant dextrin), inulin 0.5g, PURE WHEY 5g, oligoisomaltose 0.5g, soybean fiber 1g, Arabic gum 0.2g, water 50mL is stirred evenly；
2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 12.4mL mixed plant greases；Institute Mixed plant grease is stated by 3.1mL olive oil, 5.1mL soybean oils, 3.2mL coconut oil, 0.7mL perilla herb oils, 0.3mL medium chain triglycerides Three esters form；
3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to after the mixed solution with water addition stabilizer agar 0.1g (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion to 200mL under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To fat powder.
Further, optionally increase suitable food thickening agent and food additives in the step 6.Wherein, The food thickening agent includes guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one of, the food additives include at least one of Aspartame, food flavor fragrance, brown sugar.More preferably For carragheen, Arabic gum, guar gum, Aspartame, food flavor fragrance.
Further, the operating procedure of the preparation method of above-mentioned cerebral apoplexy tailored version clinical nutrition formula is both needed in indifferent gas It is carried out under the protection of body, used inert gas is nitrogen, argon gas, helium etc..It is carried out under the protection of inert gas above-mentioned Operating procedure can prevent the danger of powder explosion.
In the present invention using include lophatherum gracile, Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn, mulberry leaf integration of drinking and medicinal herbs ingredient, Have after mentioned component compatibility synergy and adjusts bodily fuctions, improve immunocompetence, prevention of cardiovascular disease, alleviate cerebral apoplexy disease Shape, the function of mitigating patient's slight illness.
Lophatherum gracile has certain antibacterial action, with the in vitro test of lophatherum gracile water decoction to staphylococcus aureus, haemolysis Property streptococcus has inhibiting effect, helps to prevent thrombosis；Lophatherum gracile also contains abundant chlorophyll simultaneously, studies have shown that Chlorophyll is the important component of many vegetables antimutagenesis, there is antitumor anti-canceration effect, because chlorophyll has stronger resist Oxidative function, this is to prevention of cardiovascular disease and anti-aging has positive effect.
Poria cocos is sweet in flavor, light, mild-natured, is used as medicine with clearing damp and promoting diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative, and modern medicine is ground Study carefully, Poria cocos can enhance body's immunity, and pachymaran has apparent antitumor and liver protecting effect.
Cape jasmine has purging intense heat relieving restlessness, the benefits of clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, to staphylococcus aureus, diplococcus meningitidis, Micrococcus catarrhalis etc. has inhibiting effect；The alcohol extracting thing of cape jasmine has sedation, and the crocetin ingredient contained by cape jasmine, which has, to be subtracted The effect of few artery sclerosis incidence.
Honeysuckle has the benefits of clearing heat and detoxicating, antibacterial anti-inflammatory, clearing and activating the channels and collaterals, research shows that chlorogenic acid contained by honeysuckle tea Bioactivity can promote human metabolism, adjust bodily fuctions, improve immunity.
Pueraria lobata contains the trace element such as zinc needed by human, iron, calcium, vitamin B1, B2 and a variety of amino acid, has very high Nutritive value, there is clearing heat and detoxicating, rising Yang expelling pathogenic factors from muscles and skin, spasmolysis and analgesia, increase brain and coronal blood glucose, improve the benefits of brain microcirculation, Help to prevent the formation of cerebral thrombus；What pueraria lobata had promotes the production of body fluid to quench thirst, antibacterial and detoxicating function, can be used for alleviating patients with cerebral apoplexy Headache syndromes.
General flavone can increase PGI2 levels in sea-buckthorn, and significantly reduce TXB2/6-keto-PGF1a ratios, research shows that TFH has certain influence to blood platelet arachidonic acid metabolic, it may be possible to by improving the dynamic unbalance between TXA2/PGI2, suppression Platelet aggregation processed promotes damaged blood vessels endothelium to restore function, and then synthesizes more PGI2, reduces blood platelet and subendothelial layer Stick, to play the role of preventing thrombosis.
Mulberry leaf have spasmolysis, and patients with cerebral apoplexy often will appear the symptom of numbness in hands and feet, be mainly nerve damage, Neurothlipsis causes, and the spasmolysis of mulberry leaf helps to alleviate muscle cramp, is applied in combination with other compositions and can be used for treating brain The numbness in hands and feet of apoplexy patient.
Using the new resource food for including ground dragon protein and peony seed oil in the present invention, have after mentioned component compatibility synergy The remarkable effect for preventing and treating thrombus, peomotes the function of blood circulation, the normal operation for ensuring lipid-metabolism.
Ground dragon protein contains the Multiple components such as clostridiopetidase A, fibrinolysin, Lumbrokinase, nucleic acid, trace element, and molecular weight exists 5000-10000 belongs to short chain small-molecule substance, can smoothly enter capilary, has micro- bolt in quickly dissolving capilary, Improve the function that offshoot circulation is established in microcirculation；The fibrinoclase being rich in ground dragon protein can activate the fiber in thrombus Protein resolvase member, is allowed to be converted into active fibrinoclase, and then the fibrin in thrombus, new Fresh thrombolysis；And fibrinoclase again can direct thrombus, the thrombolysis of oldness；Plasmin Solve enzyme does not influence internal clotting mechanism again while thrombus, and the side effect not caused bleeding is patients with cerebral apoplexy Excellent selection；
Peony seed oil is rich in linoleic acid, and linoleic acid proportion is 23.34%.Studies show that, linoleic acid can be protected Brain has benefited from blood pressure reduction, platelet aggregation is suppressed and the increased work of erythrocyte deformability from ishemic stroke With.Meanwhile high cholesterol is the important risk factor of atherosclerosis, and atherosclerosis is easy to form thrombus, thrombus Fast Growth then can slowly block artery, influence the proper flow of (reduction) blood, thrombus is the potential of apoplexy, coronary heart disease etc. Reason；And linoleic acid and lipid-metabolism are in close relations, internal cholesterol will be combined with aliphatic acid could transfer progress in vivo Eubolism, after linoleic acid lacks, cholesterol transfer is obstructed and cannot carry out eubolism, will deposit, eventually lead in vivo Disease, giving patients with cerebral apoplexy and supplementing abundant linoleic acid contributes to the normal operation of lipid-metabolism, contributes to pre- preventing thrombosis It is formed.
In addition, the present invention is also selectively added to including Rhizoma Chuanxiong, Fructus Corni, winter creeper, Radix Angelicae Sinensis, Radix Notoginseng these types Chinese medicine Ingredient has after mentioned component compatibility synergy and removes thrombus, improve blood circulation, increase cerebral blood flow (CBF), protection cerebral injury, alleviate The effect of cranial nerve symptom.
Rhizoma Chuanxiong can be used for the cranial vascular disease that treatment includes cerebral apoplexy.Rhizoma Chuanxiong can increase cerebral blood flow (CBF), improve blood Rheological characteristic increases cerebrovascular dynamic blood volume, reduces cerebrovascular peripheral resistance, has prevention brain water caused by hypoxic-ischemic Swollen function；Blood platelet is one of visible component of blood, and platelet aggregation can cause thrombosis, thrombus to have again strong Promote platelet aggregation and cause vasoconstrictor effects, ligustrazine can release vascular smooth muscle spasmus, reduce blood viscosity, antiplatelet Aggregation has antithrombotic effect.
There is tonifying liver to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., adjust the benefits of battalion's arrest sweating for Fructus Corni, and Chinese medicine thinks, cerebral apoplexy and liver, kidney two are dirty closely related, special Be not the elderly of the sequelae and convalescence in cerebral apoplexy, kidney deficiency and liver, disturb on interior wind for cause a disease this, Fructus Corni applies to Patients with cerebral apoplexy can suit the interpretation of the cause, onset and process of an illness well, obtain more satisfied clinical efficacy.
Winter creeper has the benefits of blood-enrich, invigorating spleen and nourishing heart, has protective effect to cerebral ischemia.Clinical research table Bright, winter creeper extract can reduce the expression of IL-1 β and TNF-α in 3,6,12,24hHou rat cerebral tissue of Reperfu- sion, have and protect The function of acute cerebral ischemia/reperfusion in rats damage is protected, protective effect may can inhibit with winter creeper extract in brain tissue IL-1 β are related with the content of TNF-α.
Radix Angelicae Sinensis has the benefits of promoting blood circulation and removing blood stasis, contributes to the nervous symptoms for treating ischemic cerebral stroke patients.Microcirculation of Nailfold Inspection is current a kind of clinically most common method understanding body microcirculating state, has become the master of Chinese medicine " syndrome of blood stasis " One of index, clinical trial results is wanted to show after angelica for treating, capillary loop number, length and bore obviously increase, Blood flow accelerates, the red blood cell depolymerization of aggregation is to restore normal fluidised form, and Microcirculation of Nailfold, which has, significantly to improve, it can be seen that, when Return to improving hemorheological property and microcirculation significant effect.
Radix Notoginseng has effects that improvement blood circulation, contains abundant total saposins in Radix Notoginseng, it can effectively soften diastole brain Portion's blood vessel keeps head blood unobstructed；The thrombus in blood can be effectively removed, and it can be inhibited to be formed again；It can also Enough cleaning blood fat reduce blood viscosity, and when unobstructed blood vessel is without hindrance, oxygen-supplying amount and nutrition supply increase naturally, head Portion can obtain due moisten.
The present invention is had the following technical effect that compared with prior art using above-mentioned technical proposal：
1) cerebral apoplexy tailored version clinical nutrition formula of the invention uses 10~15：25~30：50~60 protein：Fat Fat：The energy supply ratio of carbohydrate provides balanced nutritional supplementation for patient.
2) 5-8 parts of lactalbumin of present invention addition, lactalbumin is good calcareous and protein source, wherein containing rich The ingredients such as rich immunoglobulin, lactoglobulin can provide the calcareous of 500~800mg per 100g protein preparations.Research is aobvious Show, in older patients with acute ischemic cerebral apoplexy patient, addition lactalbumin early enteral nutrition can be to Nutritional Status of Patients, immune The complications such as function, pulmonary infection, fracture and prognosis have remarkable result.
3) cerebral apoplexy tailored version clinical nutrition formula of the invention gives patient's 1.5-1.8g/kg protein, the results show that Patient TP, ALB, Hb decline equal unobvious and ALB, Hb are increased after two weeks, to show a certain range internal protein Supply amount increase can supplement rapidly the protein of consumption, effectively slow down the decomposition of body protein progressive, prevent or correct and is low The generation of proteinemia.
4) present invention strengthens taurine, and taurine is capable of providing human body oxidation resistance, enhances immunity of organisms, taurine It can inhibit its transhipment on cell membrane, with homocysteine competitive binding receptor so as to reduce with high homotype The homocysteine of the Patients with Cerebral Infarction of cysteinaemia is horizontal.Studies have shown that hinders process in cerebral ischemia re-pouring pumping Content of taurine increases in midbrain, can have various nerves such as anti-excitatory neuron poison, Green Tea Extract, stabilizing cell membrane to protect Shield acts on, while taurine also has effects that promote ischemic local cerebral blood flow.
5) present invention addition medium chain triglyceride, medium chain triglyceride (MCT) have hydrolysis in vivo, oxidation rapid, disobey The features such as relying camitine transporter, the effect for having significant section nitrogen, improving blood fat can significantly correct the negative nitrogen of patients with cerebral apoplexy Balance.
6) present invention strengthens magnesium, and magnesium participates in including protein synthesis, cellular energy more than 300 kinds in the form of confactor Synthesis and storage etc. metabolic response, have maintain neuro-muscular signal transduction, angiokinesis and blood pressure control, insulin The physiological function of secretion.Animal experiment study shows that magnesium has and reduces blood pressure, improve lipid metaboli and glycometabolism, inhibit blood platelet Activation and the effect be aggregated, improve endothelial function, is anti-inflammatory, stablizing atherosclerotic plaque, delaying atherosclerosis, having reduces The effect that cerebral apoplexy occurs.
7) present invention is using a variety of water-soluble type vitamins of rational proportion, the conditioning agent that niacin is metabolized as blood lipids It plays an important role to the metabolism of cholesterol, in clinical intervention, niacin can be by increasing internal high-density lipoprotein cholesterol Level significantly reduces the incidence of cardiovascular and cerebrovascular disease；Folic acid and vitamin B12Serum homocysteine level is reduced, is ground Studying carefully display Supplement of folic acid can make serum homocysteine level decline 25%, replenishing vitamins B12After can further decline 7%, Have the function of reducing cerebral apoplexy.
8) liposoluble vitamin of present invention addition rational proportion, can be used for preventing the generation of cerebral apoplexy.Vitamin D has It reduces blood pressure, improves endothelial function, is anti-inflammatory, improving the effects that insulin resistance, there is benefit to angiocarpy, one perspective to grind The meta analysis results studied carefully show that the reduction of serum 25-hydroxyvitamin D concentration is proportionate with cerebral apoplexy.
Cerebral apoplexy is in national residents cause of the death first place, and underfed wind occurs in acute apoplexy phase and reconvalescent Danger is higher and closely related with clinical badness come-off.It is reported that 24.3%~52.6% patients with cerebral apoplexy is with seriously gulping down Pharynx is difficult, and therefore, carrying out EN support by nose catheter is just particularly important.Enteral nutrition (EN) is used through gastrointestinal tract Oral or tube feed is metabolized the nutritional support mode of the nutrient matrix and other various nutrients that need to provide, due to enteral nutrition Closer to physiology course, so in recent years, the application of early enteral nutrition is on the increase, and show many better than parenteral battalion Foster feature helps to improve patient body function for patients with cerebral apoplexy supplement enteral nutrition to general equilibrium, accelerates illness Restore.
The present invention is plain by the basal nutrient of selection rational proportion, while adding, there are adjusting bodily fuctions, raising to be immunized Ability removes thrombus, improves blood circulation, protection cerebral injury, the dietary fiber for alleviating cranial nerve symptom, diet essence, medicine food The special dietaries substances such as same derived components, natural plants compound, new resource food, and adjust its proportioning and carried out with basal nutrient element The cerebral apoplexy tailored version clinical nutrition formula of compatibility synergy, the present invention made is easier to be absorbed by patients with cerebral apoplexy, to fully The effect of playing each component solves patients with cerebral apoplexy in the underfed shape in acute apoplexy phase and convalescence generally existing Condition improves body quality, alleviates illness, accelerates state of an illness recovery.
Specific implementation mode
The present invention provides a kind of cerebral apoplexy tailored version clinical nutrition formulas, including following component and its parts by weight：11- 20 parts of protein, 10-12 parts of fat, 55-60 parts of carbohydrate, 6-9 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.01-1 parts Diet essence, 0.05-1 parts of integration of drinking and medicinal herbs ingredients, 0.02-3 parts of natural plants compounds and 0.05-2 parts of new resource foods；Its In, the integration of drinking and medicinal herbs ingredient include in lophatherum gracile, Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn, mulberry leaf, oyster, Radix Glycyrrhizae extremely Few one kind；Wherein, the new resource food includes first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, leaf of bamboo Huang Ketone, casein phosphopeptide, avenabeta glucosan, dragon protein, peony seed oil, yeast beta-dextran, newborn mineral salt, pueraria root powder, At least one of Rosa roxburghii Tratt, xylo-oligosaccharide.
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention, But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Cerebral apoplexy tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.5g, soybean protein isolate 6.4g, skimmed milk power 5.8g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, taurine 0.12g；Olive oil 2.83g, soybean Oily 4.58g, coconut oil 2.84g, perilla herb oil 0.66g, medium chain triglyceride 0.27g；Maltodextrin 43.56g, tapioca 11.63g；Water-soluble dietary fiber 6.36g, soybean fiber 1.82g；Calcium 0.3g, phosphorus 0.2g, potassium 0.1g, sodium in macroelement 0.3g, magnesium 0.15g；Iron 0.01g, zinc 0.007g in trace element；Vitamin A 0.0007g, beta carotene 0.017g, dimension life Plain D30.000001g, vitamin E 0.009g；Vitamin B1 0.001g, vitamin B20.001g, vitamin B6 0.001g、 Vitamin B120.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Coixlacrymajobi powder 0.1g, oatmeal 0.1g；Lophatherum gracile 0.04g, Poria cocos 0.04g, cape jasmine 0.04g, honeysuckle 0.04g, pueraria lobata 0.04g, sea-buckthorn 0.04g, mulberry leaf 0.04g；Ground dragon protein 0.04g, peony seed oil 0.02g；L-cn 0.64g.
Embodiment 2
Cerebral apoplexy tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.5g, soybean protein isolate 6.4g, skimmed milk power 5.8g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, taurine 0.12g；Olive oil 2.83g, soybean Oily 4.58g, coconut oil 2.84g, perilla herb oil 0.66g, medium chain triglyceride 0.27g；Maltodextrin 43.56g, tapioca 11.63g；Water-soluble dietary fiber 6.36g, soybean fiber 1.82g；Calcium 0.3g, phosphorus 0.2g, potassium 0.1g, sodium in macroelement 0.3g, magnesium 0.15g；Iron 0.01g, zinc 0.007g in trace element；Vitamin A 0.0007g, beta carotene 0.017g, dimension life Plain D30.000001g, vitamin E 0.009g；Vitamin B1 0.001g, vitamin B20.001g, vitamin B6 0.001g、 Vitamin B120.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Coixlacrymajobi powder 0.1g, oatmeal 0.1g；Lophatherum gracile 0.04g, Poria cocos 0.04g, cape jasmine 0.04g, honeysuckle 0.04g, pueraria lobata 0.04g, sea-buckthorn 0.04g, mulberry leaf 0.04g；Ground dragon protein 0.04g, peony seed oil 0.02g；L-cn 0.64g；Rhizoma Chuanxiong 0.1g, Fructus Corni 0.1g, winter creeper 0.1g, Radix Angelicae Sinensis 0.1g, Radix Notoginseng 0.1g.
Embodiment 3
Cerebral apoplexy tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.5g, soybean protein isolate 6.4g, skimmed milk power 5.8g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, taurine 0.12g；Olive oil 2.83g, soybean Oily 4.58g, coconut oil 2.84g, perilla herb oil 0.66g, medium chain triglyceride 0.27g；Maltodextrin 43.56g, tapioca 11.63g；Water-soluble dietary fiber 6.36g, soybean fiber 1.82g；Calcium 0.3g, phosphorus 0.2g, potassium 0.1g, sodium in macroelement 0.3g, magnesium 0.15g；Iron 0.01g, zinc 0.007g in trace element；Vitamin A 0.0007g, beta carotene 0.017g, dimension life Plain D30.000001g, vitamin E 0.009g；Vitamin B1 0.001g, vitamin B20.001g, vitamin B6 0.001g、 Vitamin B120.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Coixlacrymajobi powder 0.1g, oatmeal 0.1g；Lophatherum gracile 0.04g, Poria cocos 0.04g, cape jasmine 0.04g, honeysuckle 0.04g, pueraria lobata 0.04g, mulberry leaf 0.04g, oyster 0.04g；Avenabeta glucosan, peony seed oil 0.02g；L-cn 0.64g.
Embodiment 4
Cerebral apoplexy tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.5g, soybean protein isolate 6.4g, skimmed milk power 5.8g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, taurine 0.12g；Olive oil 2.83g, soybean Oily 4.58g, coconut oil 2.84g, perilla herb oil 0.66g, medium chain triglyceride 0.27g；Maltodextrin 43.56g, tapioca 11.63g；Water-soluble dietary fiber 6.36g, soybean fiber 1.82g；Calcium 0.3g, phosphorus 0.2g, potassium 0.1g, sodium in macroelement 0.3g, magnesium 0.15g；Iron 0.01g, zinc 0.007g in trace element；Vitamin A 0.0007g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, dimension Raw element B120.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Coixlacrymajobi powder 0.1g, oatmeal 0.1g；Lophatherum gracile 0.04g, Poria cocos 0.04g, cape jasmine 0.04g, honeysuckle 0.04g, pueraria lobata 0.04g, sea-buckthorn 0.04g, mulberry leaf 0.04g；Ground dragon protein 0.01g, peony seed oil 0.01g；L-cn 0.64g.
Embodiment 5
Cerebral apoplexy tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.5g, soybean protein isolate 6.4g, skimmed milk power 5.8g, bovine colostrum 0.1g, ocean fish oligopeptide 0.1g, taurine 0.12g；Olive oil 2.83g, soybean Oily 4.58g, coconut oil 2.84g, perilla herb oil 0.66g, medium chain triglyceride 0.27g；Maltodextrin 43.56g, tapioca 11.63g；Water-soluble dietary fiber 6.36g, soybean fiber 1.82g；Calcium 0.3g, phosphorus 0.2g, potassium 0.1g, sodium in macroelement 0.3g, magnesium 0.15g；Iron 0.01g, zinc 0.007g in trace element；Vitamin A 0.0007g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, dimension Raw element B12 0.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Coixlacrymajobi powder 0.01g, oatmeal 0.01g；Lophatherum gracile 0.01g, Poria cocos 0.01g, cape jasmine 0.01g, honeysuckle 0.01g, pueraria lobata 0.01g, sea-buckthorn 0.01g, mulberry leaf 0.01g；Ground dragon protein 0.01g, peony seed oil 0.01g；L-cn 0.64g.
Embodiment 6
A kind of preparation method of cerebral apoplexy tailored version clinical nutrition formula as described in 1~embodiment of embodiment 5 is as follows：
1) powdered oil (powder fat) is prepared：
A) wall material aqueous solution is prepared：Take maltodextrin 10g, soybean protein isolate 4g, skimmed milk powder 11g, dietary fiber 2g (resistant dextrin), inulin 0.5g, PURE WHEY 5g, oligoisomaltose 0.5g, soybean fiber 1g, Arabic gum 0.2g, water 50mL is stirred evenly and (is had ready conditions and heat while stirring to 60 DEG C, keep 30 minutes postcoolings to room temperature).
B) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in (olive oil in 12.4mL greases 3.1mL, soybean oil 5.1mL, coconut oil 3.2mL, perilla herb oil 0.7mL, medium chain triglyceride 0.3mL).
C) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in wall material aqueous solution.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1g (a concentration of 0.2%) of total solid is settled into after mixed solution with water 200mL (a concentration of 25%) of total solid, high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous dry, prepare liposoluble vitamin powder with 60~80 mesh screenings；Using the water soluble vitamin of predetermined weight number as Core material is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, and sprays instantaneous dry, is prepared with the screening of 60~80 mesh water-soluble Property vitamin powder；
4) by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, diet essence, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
5) mixing machine that the powder obtained by step 1)~step 4) is sequentially added to cone-type mixer or other forms is mixed Uniformly obtained formula mixture is closed, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, food flavor fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 7
The present embodiment is verification embodiment.
This verification embodiment verifies shadow of the cerebral apoplexy tailored version clinical nutrition formula of the present invention to patients with cerebral apoplexy It rings.Electuary and following comparative example of the present embodiment using the formula preparation of embodiment 1,2 and 3：
Control group：Using conventional nutrient powder；
Experimental group 1：The nutrient powder prepared using the nutrient formulation of embodiment 1；
Experimental group 2：The nutrient powder prepared using the nutrient formulation of embodiment 2；
Experimental group 3：The nutrient powder prepared using the nutrient formulation of embodiment 3；
Experimental group 4：The nutrient powder prepared using integration of drinking and medicinal herbs ingredient is deleted in the nutrient formulation of embodiment 1；
Experimental group 5：The nutrient powder prepared using new resource food is deleted in the nutrient formulation of embodiment 1；
Experimental group 6：The nutrient powder prepared using medium chain triglyceride is deleted in the nutrient formulation of embodiment 1；
The patients with cerebral apoplexy 30 of corresponding nutrient powder is voluntarily taken in every group of selection above, and selected patient is with hemiplegia, language Speech is unable to based on symptom.It is edible that above-mentioned nutrient powder is given during maintaining normal therapeutic.After the nutritional intervention time is 2 weeks, 2 weeks total Carry out therapeutic effect observation.The result is shown in the following table 1.
Paralyzed limbs Myodynamia recovery situation after observation treatment：0 grade：Paralysis completely；1 grade：Muscle is collapsible, but cannot complete Action；2 grades：Limbs can be moved in bed surface, but cannot be lifted；3 grades：Limbs can be lifted away from bed surface, but be unable to resistive drag force；4 grades：It can do Resistive drag force acts, but poor compared with normal person；5 grades：Muscular strength is normal.
Clinical efficacy evaluation criteria：
It cures：Symptom and sign disappears, and takes care of oneself, and for Myodynamia recovery to 5 grades, language competence restores normal；
It is effective：Symptom and sign is obviously improved, and muscular strength reaches 3~4 grades, is spoken and is formed a complete sentence and express incomplete；
Effectively：Symptom and sign part improves, and limb function has a certain recovery, it cannot be said that word, word；
In vain：Through controlling two weeks or more, for sings and symptoms without improvement, muscular strength is also unchanged, and language cannot or substantially cannot.
Therapeutic effect (n (%)) of the 1 cerebral apoplexy tailored version clinical nutrition formula of the present invention of table to patients with cerebral apoplexy
As can be known from the above table, cerebral apoplexy tailored version clinical nutrition formula of the present invention can be obviously improved patients with cerebral apoplexy Therapeutic effect.It is not added with the integration of drinking and medicinal herbs ingredient of the present invention, the clinical nutrition formula of new resource food or medium chain triglyceride Its effect is higher than the control group using conventional nutrient powder, but is slightly below added to the integration of drinking and medicinal herbs ingredient of the present invention, new resources food The experimental group of the clinical nutrition formula of product and medium chain triglyceride.Illustrate integration of drinking and medicinal herbs ingredient, new resource food or medium chain triglyceride The components such as three esters are essential for the realization for improving cerebral apoplexy symptom effect, with the mutually auxiliary phase of other components of the present invention At giving full play to respective effect, excellent effect could be obtained.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and Modification, all should be contained within the scope of the invention.

Claims (10)

1. a kind of cerebral apoplexy tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight：11-20 Part protein, 10-12 parts of fat, 55-60 parts of carbohydrate, 6-9 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01- 0.04 part of trace element, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.01-1 portions of diets Essence, 0.05-1 parts of integration of drinking and medicinal herbs ingredients, 0.02-3 parts of natural plants compounds and 0.05-2 parts of new resource foods；
Wherein, the integration of drinking and medicinal herbs ingredient include in Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn, mulberry leaf, oyster, Radix Glycyrrhizae extremely Few one kind；
Wherein, the new resource food include first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, Casein phosphopeptide, avenabeta glucosan, dragon protein, peony seed oil, yeast beta-dextran, newborn mineral salt, pueraria root powder, thorn At least one of pears, xylo-oligosaccharide.
2. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that in the nutrient formulation, Protein：Fat：The productivity ratio of carbohydrate is 10~15：25~30：50~60.
3. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that the protein according to The amount for giving patient 1.5-1.8g/kg exists.
4. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that the protein includes 5- 8 parts of lactalbumin.
5. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that the fat includes middle chain Triglycerides, olive oil, soybean oil, coconut oil, perilla herb oil.
6. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that the integration of drinking and medicinal herbs ingredient Including lophatherum gracile, Poria cocos, cape jasmine, honeysuckle, pueraria lobata, sea-buckthorn and mulberry leaf.
7. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that the new resource food packet Include ground dragon protein and peony seed oil.
8. cerebral apoplexy tailored version clinical nutrition formula according to claim 1, which is characterized in that also comprise the following components and The Chinese medicine of parts by weight：0-0.1 parts of Rhizoma Chuanxiong, 0-0.1 parts of Fructus Corni, 0-0.1 parts of winter creeper, 0-0.1 parts of Radix Angelicae Sinensis, Radix Notoginseng 0-0.1 Part.
9. the preparation method of the cerebral apoplexy tailored version clinical nutrition formula according to any one of claim 1-8, feature It is, includes the following steps：
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, impregnate 3~4 hours, then to soak decoct 30~60min, filtering removal raw material, leaves and takes decoction liquor, is spray-dried to decoction liquor, and medicine food is prepared with 60~80 mesh screenings Homologous component powders；
Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the liposoluble vitamin of predetermined weight number It as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous time under high pressure For 10~15min, instantaneous drying of spraying then is carried out, liposoluble vitamin powder is prepared with 60~80 mesh screenings；By predetermined weight The water soluble vitamin of number is measured as core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, spray instantaneous dry It is dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 4, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, diet essence, Natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 5, the powder obtained by step 1~4 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, by sterilization It is spare after processing；
Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution It is at least one；
Wherein, the sequence of step 1~4 can be replaced mutually.
10. preparation method according to claim 9, which is characterized in that prepare fat powder in the step 1 and specifically include Following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 10g, soybean protein isolate 4g, skimmed milk powder 11g, dietary fiber 2g (resistances Dextrin), inulin 0.5g, PURE WHEY 5g, oligoisomaltose 0.5g, soybean fiber 1g, Arabic gum 0.2g, water 50mL stir It mixes uniformly；
2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 12.4mL mixed plant greases；It is described mixed Vegetable fat is closed by 3.1mL olive oil, 5.1mL soybean oils, 3.2mL coconut oil, 0.7mL perilla herb oils, 0.3mL medium chain triglycerides Composition；
3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the mixed plant grease and the wall material aqueous solution of addition Over emulsfication agent Tween 80 that add Over emulsfication agent monoglyceride is abundant Mixing, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to 200mL to addition stabilizer agar 0.1g after the mixed solution with water (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, and collection obtains fat Fat powder.
CN201810445031.6A 2018-05-10 2018-05-10 Cerebral apoplexy tailored version clinical nutrition formula and preparation method thereof Pending CN108669540A (en)

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