CN108663303A - A kind of blood analyser - Google Patents

Abstract

The invention relates to a blood analyzer, comprising a sample suction and dispensing module, a reagent dispensing module, a fluid power and waste liquid processing module, a red blood cell and platelet measuring module, a white blood cell classification measuring module and a biochemical measuring module. The biochemical measurement module is used for the reaction measurement of biochemical projects, including: colorimetric device, reagent chamber, cleaning station and colorimetric detection block, wherein the colorimetric device includes a colorimetric disk and N cuvettes on the colorimetric disk. The color detection block includes a light-emitting diode array, a light guide tube, a collimating lens, and a photodiode. N cuvettes are arranged in a circle on the cuvette, and the cuvette rotates to drive the cuvette through the collimating lens and the photodiode. between. The present invention integrates routine blood test and biochemical detection into one, and can simultaneously detect blood routine test, C-reactive protein, SAA and other inflammatory indicators in one test with one instrument and one tube of blood, saving clinical use cost and labor cost.

Description

A blood analyzer

technical field

The invention relates to the field of medical equipment, in particular to a blood analyzer.

Background technique

In clinical application, it is often encountered that some patients need to detect blood routine and some special proteins at the same time to diagnose whether the patient is suffering from bacterial or viral infection. Blood routine testing and special protein detection in blood use different methodologies, so Usually done by different instruments. For example, in clinical blood routine testing, the flow cytometry-based five-differentiation hematology analyzer is used to count and classify white blood cells in whole blood samples, count red blood cells and platelets, and colorimetrically detect hemoglobin in red blood cells; Quantitative detection of quantitative detection, using a biochemical analyzer based on the principle of spectrophotometry or a special protein analyzer to detect proteins, antibodies, etc. in serum samples, this conventional detection method brings the following problems: 1. Two tubes of blood samples to complete the test: For highly automated hematology analyzers and biochemical analyzers, the samples are not compatible. Hematology analyzers use whole blood, while biochemical analyzers use serum. Clinical testing requires two tubes of blood samples from patients to be tested separately, which increases the suffering of patients. The results cannot be issued at the same time. Routine testing is faster than biochemical testing, which increases the waiting time for reports; 2. Complete the test with one tube of blood sample: take a tube of blood from the patient, use an automatic blood analyzer to detect blood routine, and use a semi-automatic special protein analyzer or test strips for special protein quantification Or semi-quantitative detection, manual processing, increased labor costs and uncertainty caused by manual operations.

In recent years, in order to meet the clinical needs for the diagnosis and detection of inflammatory infections in patients, some manufacturers of blood cell analyzers have launched five-differentiation blood analyzers and C-reactive protein all-in-one machines for clinical blood sample detection of bacterial infections. Doctors can use a tube of blood , one instrument, one measurement to obtain blood routine test and C-reactive protein test results, and to diagnose bacterial infection through white blood cell count, neutrophil ratio and C-reactive protein concentration value. This new blood analysis instrument is widely used in clinical applications. It is generally welcomed, but it is far from meeting the needs; the main problem is that the patient's infection may be bacterial or viral, and white blood cells, neutrophils, and C-reactive protein have good specificity for bacterial infections, and for viral infections, they are There is no obvious specificity, so it is necessary to broaden the scope of blood routine and special protein detection, and provide more detection indicators.

Contents of the invention

The object of the present invention is to solve the above-mentioned disadvantages in the prior art.

To achieve the above object, the present invention provides a blood analyzer, comprising a sample suction and dispensing module, a reagent dispensing module, a fluid power and waste liquid treatment module, a red blood cell and platelet measurement module, a white blood cell classification measurement module, and a biochemical measurement module; The sample dispensing module draws blood samples outside the machine, and distributes the blood samples to the white blood cell classification measurement module and biochemical measurement module; the reagent dispensing module dispenses the quantitative detection reagents required by the red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module according to the time requirements Distributed to the red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module; the fluid power and waste liquid treatment module discharges the waste liquid generated by the sample suction and dispensation module, red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module Outside the machine, at the same time provide the required sheath fluid for the red blood cell and platelet measurement module; the red blood cell and platelet measurement module is used to detect the number and size of red blood cells, as well as the number and size of platelets; the white blood cell classification measurement module is used for white blood cell classification; the biochemical measurement module is used For the reaction measurement of biochemical projects, the biochemical measurement module includes: colorimetric device, reagent chamber, cleaning station and colorimetric detection block, wherein the colorimetric device includes a colorimetric disk and N cuvettes located on the colorimetric disk. The absorbance of each sample reaction solution in the cuvette, wherein, N is a positive integer, and N is greater than or equal to 2; the colorimetric detection block includes a light-emitting diode array, a light guide tube, a collimating lens and a photodiode, and N cuvettes Arranged in a circle on the cuvette, the cuvette rotates to drive the cuvette to pass between the collimating lens and the photodiode.

Preferably, the sample aspirating and dispensing module includes a sample aspirating needle, a cleaning swab, a first solenoid valve and a second solenoid valve.

Preferably, the reagent dispensing module includes: a reagent injection pump, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve and a sixth solenoid valve.

Preferably, the fluid power and waste liquid treatment module includes: a first diaphragm pump, a second diaphragm pump, a third diaphragm pump, a positive pressure pool, a sheath liquid pool, a seventh solenoid valve, an eighth solenoid valve, a ninth solenoid valve, The tenth solenoid valve, the eleventh solenoid valve, the twelfth solenoid valve, the thirteenth solenoid valve, the fourteenth solenoid valve, and the fifteenth solenoid valve.

Preferably, the red blood cell and platelet measurement module includes a counting tank, a sheath fluid isolation tank, a waste liquid isolation tank, an impedance sample injection pump, a sixteenth solenoid valve, a seventeenth solenoid valve, an eighteenth solenoid valve, and a nineteenth solenoid valve , The twentieth solenoid valve, the twenty-first solenoid valve.

Further preferably, the counting cell includes a counting cell rear cell, a counting cell front cell, a gemstone hole sealing gasket, a gemstone hole, a sample needle seat, a sample needle, a front cell electrode tube, a rear cell drain port, and a rear cell electrode; wherein, the counting cell The back pool of the pool is connected to the negative pole through the electrode tube of the front pool, and the front pool of the counting pool is connected to the positive pole through the electrode of the back pool.

Preferably, the leukocyte classification measurement module includes: a reaction cell, a flow chamber, a sample injection pump, a sheath fluid injection pump, a waste liquid pool, a twenty-second solenoid valve, a twenty-third solenoid valve, a twenty-fourth solenoid valve, a Twenty-five solenoid valves, twenty-sixth solenoid valves, and twenty-seventh solenoid valves.

Preferably, the cuvette comprises a cuvette heating block, a cuvette support, a cuvette rotating shaft, a cuvette motor, and a cuvette heating film, wherein the middle part of the cuvette support is fixed on the cuvette rotating shaft , the top of the cuvette is suspended on the edge of the cuvette holder, the cuvette heating block includes a bottom plate part and two hollow cylindrical parts with the same height and concentricity, the two hollow cylindrical parts and the bottom plate part are integrally formed, and the two hollow cylinders The part and the bottom plate part form a circular groove, the cup body of the cuvette is located in the circular groove, the cuvette heating film is used to heat the cuvette heating block, and then heat the air in the circular groove .

The present invention has the following beneficial effects: (1) Integrating five-class blood routine testing and biochemical testing into one, one instrument, one tube of blood, and one test can simultaneously detect blood routine testing, C-reactive protein, SAA and other inflammatory indicators, saving clinical use costs and Labor costs. (2) The system is simple in structure, low in maintenance and manufacturing costs, and high in reliability: compared with conventional hematology analyzers, only the colorimetric disc, reagent chamber and photoelectric detection module are added, and the photoelectric detection module adopts multi-channel monochromatic light source compound analysis. The real-time detection method has multiple monochromatic light-emitting diodes forming an array to achieve colorimetric detection of different wavelengths. (3) The system is flexible and convenient to expand. In addition to blood routine, it can support multiple biochemical detection items, covering commonly used clinical inflammatory indicators.

Description of drawings

Fig. 1 is a schematic structural view of a blood analyzer provided by the present invention;

Fig. 2 is a schematic structural diagram of a counting pool provided by an embodiment of the present invention;

Fig. 3 is a kind of Coulter schematic diagram provided by the embodiment of the present invention;

FIG. 4 is a sample pulse diagram of sheath current impedance provided by an embodiment of the present invention;

Fig. 5 is a schematic diagram of a biochemical measurement principle provided by an embodiment of the present invention;

Fig. 6 is a schematic structural diagram of a colorimetric disc provided by an embodiment of the present invention.

Detailed ways

The technical solutions of the present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments.

As shown in Figures 1-6, the blood analyzer provided by the embodiment of the present invention includes a sample suction and dispensing module 1, a reagent dispensing module 2, a fluid power and waste liquid treatment module 3, a red blood cell and platelet measurement module 4, and a white blood cell classification measurement module 5 and biochemical measurement module 6.

As shown in Figure 1, the sample suction and dispensing module 1: realize the suction of blood samples outside the machine, and distribute them to the reaction pools in the white blood cell classification measurement module and the colorimetric cells in the biochemical measurement module; after completing the sample suction and dispensing, clean and enter the next measurement Standby state; its main components include: sampling needle 101 , cleaning swab 102 , first solenoid valve 103 and second solenoid valve 104 .

Reagent dispensing module 2: distribute the quantitative detection reagents required by each measurement module to the red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module according to time requirements; its main components include: reagent injection pump 201, third solenoid valve 202 , the fourth solenoid valve 203 , the fifth solenoid valve 204 , and the sixth solenoid valve 205 .

Fluid power and waste liquid treatment module 3: discharge the waste liquid produced by other modules processing samples outside the machine, and at the same time provide the required sheath fluid for the red blood cell and platelet measurement module; its main components include the first diaphragm pump 301, the second diaphragm Pump 302, third diaphragm pump 303, positive pressure pool 304, sheath fluid pool 305, seventh solenoid valve 306, eighth solenoid valve 307, ninth solenoid valve 308, tenth solenoid valve 309, eleventh solenoid valve 310, The twelfth solenoid valve 311 , the thirteenth solenoid valve 312 , the fourteenth solenoid valve 313 , and the fifteenth solenoid valve 314 .

Red blood cell and platelet measurement module 4: use the sheath flow impedance method to detect the number and size of red blood cells and platelets, and complete cell measurement and sensor cleaning in each measurement process; its main components include: counting pool 401, sheath fluid isolation pool 402, waste Liquid isolation tank 403, impedance sample injection pump 404, sixteenth solenoid valve 405, seventeenth solenoid valve 406, eighteenth solenoid valve 407, nineteenth solenoid valve 408, twentieth solenoid valve 409, twenty-first solenoid valve Solenoid valve 410.

Leukocyte classification measurement module 5: Detect the number of white blood cells by optical scattering method and perform white blood cell classification according to the scattered light signal. Among them, white blood cell counting and classification are two measurement processes, and the samples treated by different reagents in the reaction pool in the module are detected by time-sharing Achieve the purpose of counting and sorting; its main components include: reaction pool 501, flow chamber 502, sample injection pump 503, sheath fluid injection pump 504, waste liquid pool 505, twenty-second solenoid valve 506, twenty-third solenoid valve 507 , the twenty-fourth solenoid valve 508 , the twenty-fifth solenoid valve 509 , the twenty-sixth solenoid valve 510 , the twenty-seventh solenoid valve 511 , and the twenty-eighth solenoid valve 512 .

Biochemical measurement module 6: Detect the absorbance of each sample reaction solution in the cuvette by optical colorimetry, and calculate the sample concentration from the change of absorbance. The module includes a reagent refrigeration structure and a cuvette structure, and the cuvette is set with multiple ratios. The color cup and the LED of a specific wavelength and the light-receiving detection component, the colorimetric disc rotating cuvette obtains the change of absorbance through the LED and the light-receiving detection component; its main components include: the colorimetric device 601 installed on the bottom plate, the reagent chamber 602, the cleaning station 603, the colorimetric detection block 604, wherein the colorimetric device includes no less than 2 cuvettes, here taking 4 cuvettes as an example, the reaction measurement of 4 biochemical items can be performed at the same time.

The implementation method of the blood analyzer will be described below.

The specific workflow of the blood analyzer system includes sample aspiration and reagent dispensing, incubation reaction, and sample detection.

The sample aspirating and dispensing and reagent dispensing specifically include: the sample injection pump 503 draws a quantitative sample into the sample needle 101 through the second electromagnetic valve 104 and the pipeline, for example, a 20ul blood sample, and the sheath fluid injection pump 504 passes through the first electromagnetic valve 103 cleans the outer wall of the sample needle 101, and at the same time, the first diaphragm pump 301 and the eleventh solenoid valve 310 extract and clean the waste liquid on the outer wall; after completion, according to the test item, the sample drawn by the sample needle 101 is quantitatively added to the reaction pool 501 and the ratio In the cuvette of the colorimetric device 601, the reagents required by each channel are quantitatively added to the reaction pool 501 and the colorimetric device 601 by the reagent injection pump 201 through the fourth electromagnetic valve 203, the fifth electromagnetic valve 204 and the sixth electromagnetic valve 205. in the cuvette; the reagent in the reagent injection pump 201 is provided by the reagent outside the machine; Four solenoid valves 508 add quantitatively, and the diluent required in the cuvette 6012 in the colorimetric device 601 is quantitatively added by the reagent injection pump 201 through the third solenoid valve 202; liquid; after the sample needle 101 is loaded, the inner wall of the sample needle 101 is cleaned by the sheath liquid injection pump 504 through the second solenoid valve 104 and the twenty-fifth solenoid valve 509, and the mechanism drives the cleaning swab 102 to move along the outer wall of the sample needle 101, and at the same time The negative pressure generated by the first diaphragm pump 301 and the eleventh solenoid valve 310 is used to extract the cleaning waste liquid.

The incubation reaction specifically includes: in the reaction tank 501, the sample and the two reagents are reacted at a certain temperature for a certain period of time. During the reaction process, the third diaphragm pump 303 generates a certain positive pressure in the positive pressure tank 304, and briefly opens the tenth solenoid valve. 309 generates air bubbles to mix the samples and reagents in the reaction pool 501; at the same time, the samples and reagents in each cuvette 6012 in the colorimetric device 601 are mixed and reacted. Station 603, a cleaning needle and an air bubble needle are installed on the cleaning station 603, a certain positive pressure is generated in the positive pressure pool 304 by the third diaphragm pump 303, and the ninth solenoid valve 308 is briefly opened to generate air bubbles, and at the same time, the cleaning station 603 inserts the air bubble needle into the corresponding Air bubbles are blown out from the cuvette, and the sample mixture in each cuvette of the colorimetric device 601 is mixed; the samples in the reaction cell 501 and each cuvette in the colorimetric device 601 are mixed and left to stand for testing;

In one example, the temperature of the reaction cell 501 is 35°C.

The sample detection and cleaning specifically include: the sample detection is performed by the red blood cell and platelet measurement module 4 to complete the measurement of the number and size of red blood cells and platelets, the white blood cell classification measurement module 5 completes the white blood cell count and classification measurement, and the biochemical measurement module 6 completes biochemical tests such as C-reactive protein. Project measurement.

The red blood cell and platelet measurement steps are as follows: the sheath fluid injection pump 504 draws a certain amount of sample into the pipeline connected to the counting tank 401 through the sixteenth solenoid valve 405, the seventeenth solenoid valve 406 and the twenty-second solenoid valve 506, and simultaneously , the positive pressure tank 304 generates a certain positive pressure, such as 40KPa, by opening the eighth solenoid valve 307 to load the sheath fluid in the sheath fluid pool 305, and the impedance sample syringe pump 404 pushes the sample in the pipeline into the counting tank 401, and at the same time the tenth Nine solenoid valve 408 opens and pushes the sheath liquid into the counting tank 401, forming a sheath flow passing through the detection area of the counting tank 401, and begins to detect red blood cells and platelets. A constant current electric field is added to the detection area, and each red blood cell and platelet will generate a volume corresponding to its own volume when passing through the detection area. Related electrical pulses, collecting electrical pulse signals to form the number and size information of the tested samples; in order to prevent the detected cells from flowing back into the detection area, open the twenty-first solenoid valve 410 at the same time to access the sheath fluid through the sheath fluid isolation pool 402 to the pool behind the counting pool 401; after detection for a certain period of time, the impedance sample syringe pump 404 finishes pushing the sample, and the eighteenth solenoid valve 407 is opened to clean the sample pipeline and the counting pool 401, and the waste liquid generated by detection and cleaning is discharged from the waste liquid isolation pool into the waste liquid pool 505; in order to prevent air bubbles from remaining in the counting pool 401, the twentieth solenoid valve 409 is opened in the cleaning process to discharge the air bubbles in the counting pool 401 into the waste liquid pool 505.

The white blood cell counting and classification measurement steps are as follows: the sheath fluid injection pump 504 sucks the white blood cell test solution reacted in the reaction pool 501 into the pipeline of the flow chamber 502 through the twenty-second solenoid valve 506 and the twenty-fourth solenoid valve 508, Close the twenty-second solenoid valve 506 and the twenty-fourth solenoid valve 508, open the twenty-third solenoid valve 507 and the twenty-seventh solenoid valve 511, and push the sample in the pipeline into the flow chamber 502 by the sample injection pump 503, At the same time, the sheath liquid injection pump 504 pushes the sheath liquid into the flow chamber 502 through the twenty-sixth electromagnetic valve 510 and the twenty-seventh electromagnetic valve 511, and the sample and the sheath liquid form a sheath flow in the flow chamber 502 and pass through the detection area, and the flow chamber 502 The detection area is coupled with the laser, and the cells entering the detection area are irradiated by the laser to generate scattered light signals, and the scattered light signals are collected to form the number, size and classification information of the measured samples; the measured samples flow into the waste liquid through the twenty-eighth solenoid valve 512 pool 505, when there is a lot of waste liquid in the waste liquid pool 505, the waste liquid is discharged out of the machine by the second diaphragm pump 302 through the thirteenth electromagnetic valve 312.

The measurement steps of biochemical items are as follows: the colorimetric disc 6011 drives each cuvette to rotate, then passes through the colorimetric detection block 604 in turn, and a plurality of light sources with different wavelengths and a light receiver are set on the colorimetric detection block 604, and each cuvette is passed through the colorimetric detection block 604. When detecting block 604, stay for no less than 1 second. According to the detected item, the specified wavelength light source in the colorimetric detection block 604 is lit, and the reaction solution in the cuvette is irradiated in time-sharing, for example, C-reactive protein in the cuvette During the project, the light sources that are lit are 375nm and 850nm wavelengths. By collecting the absorbance of these two wavelengths, the sample concentration of the measured project is calculated; after the measurement is completed, the cleaning needle is driven by the cleaning station 603 into the cuvette 6012, and the second diaphragm pump 302 and the fourteenth solenoid valve 313 are turned on to absorb the reaction solution in the cuvette 6012, and then the reagent injection pump 201 passes the third solenoid valve 202 to inject the diluent into the cuvette 6012 through the cleaning needle of the cleaning station for cleaning. Color cup 6012 until no sample remains.

In one example, as shown in Figure 2, the counting cell 401 is a sheath flow impedance counting cell combined with flow cytometry and the "Coulter" principle. Hole sealing gasket 4013, jewel hole 4014, sample needle seat 4015, sample needle 4016, front cell electrode tube 4017, rear cell drain port 4018, rear cell electrode 4019; among them, the counting cell rear cell 4011 is connected to the front cell electrode tube 4017 The front cell 4012 of the counting cell is connected to the positive electrode through the rear cell electrode 4019, thereby forming a constant current electric field in the jewel hole; in order to prevent the ionization and oxidation of the positive electrode, the rear cell electrode 4019 is made of platinum material. When the sample is injected from the sample needle 4016, the sheath fluid is injected from the sheath fluid inlet of the forebay, and the sample cells are wrapped by the sheath fluid. When passing through the jewel hole 4014, the sheath fluid is replaced, which causes the internal resistance of the jewel hole 4014 to rise and generate electrical pulses. The size of the cell is determined by the sheath fluid. The pulse amplitude and the number of cells determine the number of pulses; after the cells flow out of the jewel hole 4014, in order to prevent the cells from flowing back into the electric field and causing signal interference, the sheath fluid is injected into the pool 4011 behind the counting pool at the same time, thereby forming a double sheath flow to escort the measured The cells directly flow into the drain port 4018 of the rear pool and flow into the waste liquid; because the sample cells are wrapped by the sheath fluid, the cells are easily arranged one by one and pass through the jewel hole 4014, so as to avoid cells overlapping due to the high sample concentration, resulting in missing cells Happening.

As shown in Fig. 3 and Fig. 4, among them, Fig. 3 is the "M" shaped pulse caused by overlapping cells when the traditional "Coulter" principle detects high-concentration cell samples, and Fig. 4 is the detection of high concentration by the sheath flow impedance counting cell in this embodiment In the case of cell pulses in cell samples, the probability of "M"-shaped pulses is greatly reduced.

In one example, the biochemical measurement module includes: a colorimetric device, a reagent chamber, a cleaning station, and a colorimetric detection block, wherein the colorimetric device includes a colorimetric disc and N cuvettes positioned on the cuvette, and the cuvettes are detected The absorbance of each sample reaction solution in the sample, wherein, N is a positive integer, and N is greater than or equal to 2; the colorimetric detection block includes a light-emitting diode array, a light guide tube, a collimating lens and a photodiode, and N cuvettes are compared The color discs are arranged in a circle, and the color comparison disc rotates to drive the color comparison cups to pass between the collimation lens and the photodiode.

In a more specific example, the cuvette includes a cuvette heating block, a cuvette support, a cuvette rotating shaft, a cuvette motor, and a cuvette heating film, wherein the middle part of the cuvette support is fixed on On the rotating shaft of the cuvette, the top of the cuvette hangs on the edge of the cuvette support. The heating block of the cuvette consists of a bottom plate part and two hollow cylindrical parts with the same height and concentricity. The two hollow cylindrical parts and the bottom plate part are integrally formed. , the two hollow cylindrical parts and the bottom plate part form a circular groove, the cup body of the cuvette is located in the circular groove, the cuvette heating film is used to heat the cuvette heating block, and then heat the circular Air in the groove.

In one example, as shown in Figure 5, the biochemical measurement module performs detection based on the principle of light absorption and colorimetry, and is characterized by multi-channel monochromatic light source composite time-sharing detection, and its structure mainly includes a cuvette 6011, a cuvette 6012, and a light-emitting diode. Array 6041, light pipe 6042, collimating lens 6043, photodiode 6044; wherein, at least N cuvettes 6012 are set on the cuvette 6011, where N is not less than 2, and in this embodiment, 4 cuvettes are set The cuvette 6012 and the cuvette 6011 drive the cuvette 6012 to rotate, passing through the optical path detection area composed of the light-emitting diode array 6041, the light guide 6042, the collimating lens 6043 and the photodiode 6044 in sequence, and each cuvette 6012 passes through the optical path detection The zone time stays for at least 1 second, and based on the item to be tested in the cuvette 6012, the system selects the designated LED array 6041 to irradiate the cuvette 6012 to be tested in time-sharing. In addition, for each item to be tested, the system selects at least two Two wavelengths are irradiated by light-emitting diode array 6041 for time-sharing colorimetry. For example, the item to be measured in cuvette 6012 is C-reactive protein (CRP). When the cup 6012 stays in the optical path detection area, the 340nm light source on the LED array 6041 is first irradiated for 0.5 seconds, and then the 850nm light source is irradiated for 0.5s. Optical signal, the system calculates the absorbance value of the test item according to the collected signal.

In one example, at least 4 light sources with different wavelengths are arranged in the present invention to combine into an LED array 6041, and a light guide tube 6042 that couples light emitted by multiple light sources is used to combine multiple monochromatic light sources into a light source with a diameter not greater than 5 mm. The detection light spot is collimated by the collimator lens 6043 and irradiated on the cuvette 6012 .

In one example, the interior of the cuvette 6012 in the present invention is 5×5mm, the optical path is 5mm, and the theoretical minimum measurable volume of each detection item is 125ul. The advantages of small reagent consumption and low cost.

In one example, as shown in Figure 6, the cuvette 6011 in the biochemical measurement module mainly includes a cuvette heating block 60111, a cuvette holder 60112, a cuvette rotating shaft 60113, a cuvette motor 60114, and a cuvette heating film Composed of 60115, wherein the cuvette heating block 60111 is made of aluminum, and the cuvette heating film 60115 is made of polyimide material, as shown in Figure 5, the cuvette 6011 adopts solid direct heating as a whole, through the colorimetric The disc heating film 60115 heats the colorimetric disc heating block 60111, and then heats the air in the colorimetric disc heating block 60111, and the cuvette 6012 is soaked in the hot air at 35°C to form an air bath effect, and the reaction solution in the cuvette is incubated and heated ; Wherein the colorimetric disc heating block 60111 is made of metal material, and the aluminum alloy material is selected in this embodiment, which has the characteristics of large heat capacity, good heat preservation effect and low cost.

The above specific implementation manners have further described the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific implementation modes of the present invention, and are not used to limit the protection scope of the present invention. Within the spirit and principles of the present invention, any modifications, equivalent replacements, improvements, etc., shall be included in the protection scope of the present invention.

Claims (8)

1. A blood analyzer, characterized in that it comprises a sample suction and dispensing module, a reagent dispensing module, a fluid power and waste liquid treatment module, a red blood cell and platelet measurement module, a white blood cell classification measurement module, and a biochemical measurement module; The sample suction and dispensing module sucks blood samples outside the machine, and distributes the blood samples to the white blood cell classification measurement module and the biochemical measurement module; The reagent dispensing module distributes the quantitative detection reagents required by the red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module to the red blood cell and platelet measurement module, white blood cell classification measurement module and biochemical measurement module according to time requirements; The fluid power and waste liquid treatment module discharges the waste liquid produced by the sample suction and dispensing module, the red blood cell and platelet measurement module, the white blood cell classification measurement module and the biochemical measurement module, and provides the required sheath for the red blood cell and platelet measurement module liquid; The red blood cell and platelet measurement module is used to detect the number and size of red blood cells, and the number and size of platelets; The leukocyte classification measurement module is used for leukocyte classification; The biochemical measurement module is used for the reaction measurement of biochemical items, and the biochemical measurement module includes: a colorimetric device, a reagent chamber, a cleaning station and a colorimetric detection block, wherein the colorimetric device includes a colorimetric disk and a colorimetric disk located on the colorimetric disk N cuvettes, detect the absorbance of each sample reaction solution in the cuvettes, where N is a positive integer, and N is greater than or equal to 2; The colorimetric detection block includes a light-emitting diode array, a light guide tube, a collimating lens and a photodiode, and the N cuvettes are arranged in a circle on the cuvette, and the cuvette rotates to drive the cuvette through between the collimating lens and the photodiode. 2 . The blood analyzer according to claim 1 , wherein the sample suction and dispensing module comprises a sample suction needle, a cleaning swab, a first electromagnetic valve and a second electromagnetic valve. 3. The blood analyzer according to claim 1, wherein the reagent dispensing module comprises: a reagent injection pump, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve and a sixth solenoid valve. 4. The blood analyzer according to claim 1, wherein the fluid power and waste liquid treatment module comprises: a first diaphragm pump, a second diaphragm pump, a third diaphragm pump, a positive pressure pool, and a sheath fluid pool , the seventh solenoid valve, the eighth solenoid valve, the ninth solenoid valve, the tenth solenoid valve, the eleventh solenoid valve, the twelfth solenoid valve, the thirteenth solenoid valve, the fourteenth solenoid valve, the fifteenth solenoid valve . 5. The blood analyzer according to claim 1, wherein the red blood cell and platelet measurement module comprises a counting tank, a sheath fluid isolation tank, a waste liquid isolation tank, an impedance sample syringe pump, a sixteenth solenoid valve, a sixth The seventeenth solenoid valve, the eighteenth solenoid valve, the nineteenth solenoid valve, the twenty solenoid valve, and the twenty-first solenoid valve. 6. The blood analyzer according to claim 1, wherein the leukocyte classification measurement module comprises: a reaction pool, a flow chamber, a sample injection pump, a sheath fluid injection pump, a waste liquid pool, and a twenty-second solenoid valve , The twenty-third solenoid valve, the twenty-fourth solenoid valve, the twenty-fifth solenoid valve, the twenty-sixth solenoid valve, and the twenty-seventh solenoid valve. 7. The blood analyzer according to claim 5, wherein the counting pool comprises a counting pool rear pool, a counting pool front pool, a jewel hole gasket, a jewel hole, a sample needle seat, a sample needle, and a front pool electrode tube, back pool drain port and back pool electrode; among them, the back pool of the counting pool is connected to the negative pole through the front pool electrode tube, and the front pool of the counting pool is connected to the positive pole through the back pool electrode. 8. The blood analyzer according to claim 1, wherein the colorimetric disk comprises a colorimetric disk heating block, a colorimetric disk support, a colorimetric disk rotating shaft, a colorimetric disk motor, and a colorimetric disk heating film, wherein , the middle part of the cuvette support is fixed on the cuvette shaft, the top of the cuvette is suspended on the edge of the cuvette support, and the cuvette heating block includes a bottom plate part and two concentric hollows of equal height The cylindrical part, two hollow cylindrical parts and the bottom plate part are integrally formed, the two hollow cylindrical parts and the bottom plate part form a circular groove, the cup body of the cuvette is located in the circular groove, and the cuvette heating film is used It is used to heat the heating block of the colorimetric disc, and then heat the air in the circular groove.