CN108578787A - A kind of absorbable bone anchoring device and preparation method thereof - Google Patents
A kind of absorbable bone anchoring device and preparation method thereof Download PDFInfo
- Publication number
- CN108578787A CN108578787A CN201810888658.9A CN201810888658A CN108578787A CN 108578787 A CN108578787 A CN 108578787A CN 201810888658 A CN201810888658 A CN 201810888658A CN 108578787 A CN108578787 A CN 108578787A
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- Prior art keywords
- anchoring device
- bone anchoring
- matrix
- ceramic
- bone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/026—Ceramic or ceramic-like structures, e.g. glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of absorbable bone anchoring device and preparation method thereof, feature is the matrix for including material for polyester polymer, and cavity is provided in matrix, Ca-P ceramic is filled in cavity；Advantage is to fill Ca-P ceramic composition in polyester polymer with physical method, so that the weight ratio of Ca-P ceramic composition reaches as high as 80% or so in bone anchoring device, this aspect can keep the microstructure of polymer, can reach high intensity using a small amount of polymer；On the other hand, promoting the additive amount of the Ca-P ceramic of bone uptake can be added according to actual needs.And after the bone anchoring device enters in vivo, material neutralizes for the acid alkaline Ca-P ceramic that can be filled formed after the matrix degradation of polyester polymer, to prevent inflammatory reaction, Ca-P ceramic therein can also play the function of induction osteocyte/bone growth simultaneously, accelerate the reparation and healing of bone, avoid formation empty in Regenerated Bone, it is ensured that the intensity of Regenerated Bone.
Description
Technical field
The present invention relates to used in clinical treatment bone fixation instrument more particularly to a kind of absorbable bone anchoring device
And preparation method thereof.
Background technology
Adsorbable bone fixing device based on polylactic acid is more and more widely used in clinical treatment.It is bone, soft
Polylactic acid-based absorbable fixed instrument is used extensively in the connection and fixation of bone, tendon, ligament etc..Polylactic acid is in vivo in environment
Lactic acid can be degraded to：D-lactic acid can be metabolized as carbon dioxide and water in human body by tricarboxylic acid cycle, and body is finally discharged
Outside；L-lactic acid can be excluded through kidney.Polylactic acid-based bone fixation medical instrument alternative metals class instrument can remove patient experience from
Second operation takes out pain and the financial burden of metal.But the bone anchoring devices such as pure made nail of polylactic acid material make
With finding that there are still problems in the process：（1）, polylactic acid catabolite in acidity, easily cause caused by acidity in vivo
Inflammatory reaction hinders symphysis and reparation；（2）, polylactic acid catabolite habitat be due to osteocyte/bone tissue can not be grown into
Cavity is formed, and then reduces the intensity of new bone, there are the risks of second fracture；（3）, poly-lactic acid material mechanical property to heat it is non-
Often sensitive, on the one hand the melting injection molding method routinely used accelerates the thermal degradation of polylactic acid ontology, substantially reduce its molecule
Amount, on the other hand, because polylactic acid crystallization rate itself is slow, conventional injection molding cooling allows it that can not form effective crystallization（Crystallinity
It is directly proportional to product strength）, the intensity that the factor of these two aspects results in polylactic acid-based bone anchoring device is low, cannot meet orthopaedics
Demand.
Invention content
Technical problem to be solved by the invention is to provide inflammatory reaction caused by a kind of acidity of avoidable catabolite,
The reparation and healing for accelerating bone prevent cavity in bone, and are greatly improved the absorbable bone anchoring device of device intensity
And preparation method thereof.
Technical solution is used by the present invention solves above-mentioned technical problem：A kind of absorbable bone anchoring device, including
Material is the matrix of polyester polymer, and cavity is provided in the matrix, Ca-P ceramic is filled in the cavity.
Further, the shape of the matrix is round bar shape or plate.
Further, the outer surface of the matrix of the round bar shape is provided with external screw thread.
Further, the polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyethanol
At least one of acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000.
Further, the Ca-P ceramic is at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
A kind of preparation method of absorbable bone anchoring device, including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix；
（2）, on matrix trepanning to form inner cavity；
（3）, fill Ca-P ceramic in the lumen, obtain bone anchoring device.
Further, the step（1）In, screw thread is processed in the outer surface of the matrix of round bar shape, forms screw.
Further, the polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyethanol
At least one of acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000.
Further, the Ca-P ceramic is at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
Compared with prior art, it is an advantage of the invention that：
（1）, due to material be polyester polymer matrix cavity in fill Ca-P ceramic, with physical method in polyesters
Ca-P ceramic composition is filled in polymer so that the weight ratio of Ca-P ceramic composition reaches as high as 80% or so in bone anchoring device,
This aspect can keep the microstructure of polymer, can reach high intensity using a small amount of polymer；On the other hand, promote bone life
The additive amount of long Ca-P ceramic can be added according to actual needs.
（2）, after the bone anchoring device enters in vivo, material be polyester polymer matrix degradation after the acidity that is formed can
The alkaline Ca-P ceramic that is filled neutralizes, to prevent inflammatory reaction, while Ca-P ceramic therein can also play induction osteocyte/
The function of bone growth accelerates the reparation and healing of bone, avoids formation empty in Regenerated Bone, it is ensured that Regenerated Bone it is strong
Degree.
Description of the drawings
Fig. 1 is the structural diagram of the present invention.
Specific implementation mode
Below in conjunction with attached drawing embodiment, present invention is further described in detail.
As shown, a kind of absorbable bone anchoring device, including matrix 1 that material is polyester polymer, in matrix 1
It is provided with cavity, Ca-P ceramic 2 is filled in cavity.
In above-described embodiment, the shape of matrix can be round bar shape or plate, also can be in the outer surface of the matrix of round bar shape
External screw thread is set, it is made to be used as nail；In addition, polyester polymer is poly-epsilon-caprolactone, Poly L-lactic acid, poly- racemization breast
At least one of acid, polyglycolic acid, wherein：The molecular weight of poly-epsilon-caprolactone>80000；Ca-P ceramic is tricalcium phosphate, hydroxyl
At least one of apatite, bio-vitric.
The preparation method of above-mentioned absorbable bone anchoring device, including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix 1；
（2）, on matrix 1 trepanning to form inner cavity；
（3）, in the lumen fill Ca-P ceramic 2, obtain bone anchoring device.
When needing using bone anchoring device as nail in use, in step（1）In, in the outer surface of the matrix 1 of round bar shape
Process screw thread.
Claims (9)
1. a kind of absorbable bone anchoring device, it is characterised in that including the matrix that material is polyester polymer, the base
It is provided with cavity in vivo, Ca-P ceramic is filled in the cavity.
2. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The shape of the matrix is circle
Stick or plate.
3. a kind of absorbable bone anchoring device as claimed in claim 2, it is characterised in that：The matrix of the round bar shape
Outer surface is provided with external screw thread.
4. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The polyester polymer is
At least one of poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, polyglycolic acid, wherein：The molecular weight of poly-epsilon-caprolactone
>80000。
5. a kind of absorbable bone anchoring device as described in claim 1, it is characterised in that：The Ca-P ceramic is phosphoric acid
At least one of tricalcium, hydroxyapatite, bio-vitric.
6. a kind of preparation method of absorbable bone anchoring device, it is characterised in that including step in detail below：
（1）, take solid polyester polymer to be processed into round bar shape or plate, as matrix；
（2）, on matrix trepanning to form inner cavity；
（3）, fill Ca-P ceramic in the lumen, obtain bone anchoring device.
7. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The step
（1）In, screw thread is processed in the outer surface of the matrix of round bar shape, forms screw.
8. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The polyester
Type of Collective object is poly-epsilon-caprolactone, Poly L-lactic acid, ploy DL lactic caid, at least one of polyglycolic acid, wherein：Poly- ε-is in oneself
The molecular weight of ester>80000.
9. a kind of preparation method of absorbable bone anchoring device as claimed in claim 6, it is characterised in that：The calcium phosphorus
Ceramics are at least one of tricalcium phosphate, hydroxyapatite, bio-vitric.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810888658.9A CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
| PCT/CN2018/121388 WO2020029502A1 (en) | 2018-08-07 | 2019-01-30 | Absorbable bone fixation device and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810888658.9A CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108578787A true CN108578787A (en) | 2018-09-28 |
Family
ID=63623084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810888658.9A Pending CN108578787A (en) | 2018-08-07 | 2018-08-07 | A kind of absorbable bone anchoring device and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108578787A (en) |
| WO (1) | WO2020029502A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020029502A1 (en) * | 2018-08-07 | 2020-02-13 | 宁波宝亭生物科技有限公司 | Absorbable bone fixation device and preparation method thereof |
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2019
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| WO1996019248A2 (en) * | 1994-12-21 | 1996-06-27 | Board Of Regents, The University Of Texas System | METHOD OF CONTROLLING pH IN THE VICINITY OF BIODEGRADABLE IMPLANTS, AND METHOD OF INCREASING SURFACE POROSITY |
| EP1433489A1 (en) * | 2002-12-23 | 2004-06-30 | Degradable Solutions AG | Biodegradable porous bone implant with a barrier membrane sealed thereto |
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| Publication number | Publication date |
|---|---|
| WO2020029502A1 (en) | 2020-02-13 |
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