CN108577863A - A kind of full-automatic whole blood acquisition piece-rate system - Google Patents
A kind of full-automatic whole blood acquisition piece-rate system Download PDFInfo
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- 239000008280 blood Substances 0.000 title claims abstract description 193
- 210000004369 blood Anatomy 0.000 title claims abstract description 189
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 76
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 76
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 60
- 239000002699 waste material Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 210000002381 plasma Anatomy 0.000 claims description 44
- 239000000725 suspension Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 239000012267 brine Substances 0.000 claims 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims 5
- 239000003755 preservative agent Substances 0.000 claims 4
- 230000002335 preservative effect Effects 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 1
- 230000000721 bacterilogical effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000009955 starching Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 abstract description 31
- 239000011780 sodium chloride Substances 0.000 abstract description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 11
- 238000012423 maintenance Methods 0.000 abstract description 11
- 210000000601 blood cell Anatomy 0.000 abstract description 10
- 230000001580 bacterial effect Effects 0.000 abstract description 8
- 210000000265 leukocyte Anatomy 0.000 abstract description 8
- 238000005070 sampling Methods 0.000 abstract description 6
- 239000000701 coagulant Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 12
- 239000012503 blood component Substances 0.000 description 10
- 239000000306 component Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 239000006285 cell suspension Substances 0.000 description 3
- 239000003761 preservation solution Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004555 blood preservation Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000005495 cold plasma Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000004023 fresh frozen plasma Substances 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
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Abstract
本发明涉及一种全自动全血采集分离系统，包括全血采集分离机和一次性使用全血采集分离装置，所述一次性全血采集分离装置包括采血器、采样袋、细菌过滤器、抗凝剂管路、抗凝剂穿刺器、红细胞保养液穿刺器、盐水穿刺器、悬浮红细胞袋、白细胞过滤器、去白悬浮红细胞袋、压力探测器接头、血泵管路、离心杯、血浆袋、冷沉淀备用袋和废液袋，所述全血采集分离机包括抗凝剂泵、血泵、离心机、血细胞探测器、管路压力探测器、抗凝剂空气探测器、血液空气探测器、血浆秤和控制器；本发明自动采集全血并分离制备成新鲜血浆和悬浮红细胞(或洗涤红细胞)，操作过程一次完成，无需将采集和分离制备分两步完成，成本较低且保证全血离体后的血浆质量。
The invention relates to a fully automatic whole blood collection and separation system, which includes a whole blood collection and separation machine and a disposable whole blood collection and separation device, the disposable whole blood collection and separation device includes a blood collection device, a sampling bag, a bacterial filter, an antibacterial Coagulant pipeline, anticoagulant puncture device, red blood cell maintenance solution puncture device, saline puncture device, suspended red blood cell bag, white blood cell filter, leukocyte-removed suspended red blood cell bag, pressure detector connector, blood pump line, centrifugal cup, plasma bag , cryoprecipitate spare bag and waste liquid bag, the whole blood collection and separation machine includes anticoagulant pump, blood pump, centrifuge, blood cell detector, pipeline pressure detector, anticoagulant air detector, blood air detector , plasma scale and controller; the present invention automatically collects whole blood and separates and prepares fresh plasma and suspended red blood cells (or washed red blood cells). Plasma quality after blood isolation.
Description
技术领域technical field
本发明涉及一种血液采集分离装置，具体来说是涉及一种全自动全血采集分离系统。The invention relates to a blood collection and separation device, in particular to an automatic whole blood collection and separation system.
背景技术Background technique
成分输血是随着医学科学和医学技术的进步，在近二十多年发展起来的输血新概念。成分输血的出现和发展是现代输血学进步的一个里程碑。成分输血明显优于全血输注。当今世界先进国家已很少直接使用全血，成分输血已是当今世界输血事业发展的方向。把全血作为制备各种血液成分的原料血，分离和制备成各种成分血，再用于临床病人；新鲜血浆、悬浮红细胞(或洗涤红细胞)和冷沉淀是其中的三种成分血。Component blood transfusion is a new concept of blood transfusion developed in the past 20 years with the advancement of medical science and medical technology. The emergence and development of component blood transfusion is a milestone in the progress of modern blood transfusion. Component blood transfusion is significantly better than whole blood transfusion. Advanced countries in the world seldom use whole blood directly, and component blood transfusion has become the development direction of blood transfusion in the world today. Whole blood is used as raw blood for preparing various blood components, separated and prepared into various blood components, and then used in clinical patients; fresh plasma, suspended red blood cells (or washed red blood cells) and cryoprecipitate are the three blood components.
现行的全血采集和分离制备技术分别在两个场所完成。The current whole blood collection and separation preparation technology is completed in two places respectively.
第一场所，采血室：全血采集，技术人员将采血器穿刺针刺入献血者手臂的静脉中，使全血经导管流入存储袋中，存储袋中含有一定量的抗凝剂血液保存液，以防止收集的血液凝结。从献血者收集固定体积的全血(例如，400ml、300ml或200ml)后，将全血放置2-6℃冰箱保存。技术人员重复上述过程，采集多名献血者的血液，等采集工作完成后，移交成分分离制备场所。The first place, blood collection room: for whole blood collection, technicians will puncture the puncture needle of the blood collection device into the vein of the blood donor's arm, so that the whole blood flows into the storage bag through the catheter, and the storage bag contains a certain amount of anticoagulant blood preservation solution , to prevent the collected blood from clotting. After collecting a fixed volume of whole blood (for example, 400ml, 300ml or 200ml) from a blood donor, the whole blood is stored in a refrigerator at 2-6°C. The technicians repeat the above process to collect the blood of several blood donors, and after the collection work is completed, hand over to the site for component separation and preparation.
第二场所，成分分离制备室：技术人员将全血袋放入大容量离心机中，其高速旋转离心，将全血在袋内分离成上层的血浆和下层的红细胞等血液组分。然后将血袋从离心机中轻轻取出，并且将全血袋转移至分浆夹或血液成分分离机等装置中，将血袋中上层的血浆挤出，分离到血浆收集袋，红细胞留在原血袋中，再将红细胞保存液注入红细胞中，制备成悬浮红细胞。待上述一些处理后，然后将血浆和红细胞悬液等单独的血液成分分开存储在不同温度中。The second place, component separation and preparation room: technicians put the whole blood bag into a large-capacity centrifuge, which rotates and centrifuges at high speed, and separates the whole blood in the bag into blood components such as upper plasma and lower red blood cells. Then gently take the blood bag out of the centrifuge, and transfer the whole blood bag to a device such as a plasma separator or a blood component separator, squeeze out the upper plasma in the blood bag, and separate it into a plasma collection bag, leaving the red blood cells in the original In the blood bag, the red blood cell preservation solution is injected into the red blood cells to prepare suspended red blood cells. After some of the above treatments, individual blood components such as plasma and red blood cell suspension are then stored separately at different temperatures.
现行技术的方法，如以上所述：需多场所(采血和分离制备两个场所)、多人工(全血采集人员和血液分离制备人员)、多设备(采血仪、大容量离心机、血液成分分离机或分浆夹)，同时，全血从采血室运送至血液分离制备室，进行分离制备之前，全血必须存储长达几小时，影响血液成分的质量，甚至超出制备新鲜冰冻血浆和冷沉淀的时机。The method of prior art, as described above: need many places (two places of blood collection and separation preparation), many labors (whole blood collection personnel and blood separation preparation personnel), multi-equipment (blood collection instrument, large-capacity centrifuge, blood component At the same time, the whole blood is transported from the blood collection room to the blood separation preparation room. Before the separation and preparation, the whole blood must be stored for several hours, which affects the quality of the blood components, even beyond the preparation of fresh frozen plasma and cold plasma. The timing of precipitation.
发明内容Contents of the invention
本发明的目的是为了解决上述所存在的缺陷，提供一种可保证全血离开人体后，以最快速度分离出新鲜血浆和悬浮红细胞(或洗涤红细胞)，提高血浆质量，为制备冷沉淀提供条件的全自动全血采集分离系统。The purpose of the present invention is to solve the above existing defects, to provide a method that can ensure that fresh plasma and suspended erythrocytes (or washed erythrocytes) are separated at the fastest speed after the whole blood leaves the human body, so as to improve the quality of plasma and provide a solution for the preparation of cryoprecipitate. Fully automatic whole blood collection and separation system.
为实现上述目的，本发明的技术方案如下：To achieve the above object, the technical scheme of the present invention is as follows:
一种全自动全血采集分离系统，其特征在于，包括全血采集分离机和一次性使用全血采集分离装置，A fully automatic whole blood collection and separation system, characterized in that it includes a whole blood collection and separation machine and a disposable whole blood collection and separation device,
其中，所述一次性全血采集分离装置包括采血器、采样袋、细菌过滤器、抗凝剂管路、抗凝剂穿刺器、红细胞保养液穿刺器、盐水穿刺器、悬浮红细胞袋、白细胞过滤器、去白悬浮红细胞袋、压力探测器接头、血泵管路、离心杯、血浆袋、冷沉淀备用袋和废液袋，所述采血器、细菌过滤器、抗凝剂管路和抗凝剂穿刺器依次通过输血管线连接，所述采血器与细菌过滤器之间依次接有三通一和三通二，所述三通一的下端口接设采样袋，所述抗凝剂穿刺器与抗凝剂管路之间依次接有三通三，所述三通三的侧端口通过输血管线分两路分别与红细胞保养液穿刺器和盐水穿刺器连接，所述三通二的上端口通过输血管线依次接有血泵管路、离心杯和血浆袋，所述三通二与血泵管路之间的输血管线上依次接有三通四和三通五，所述三通四的侧端口通过输血管线与悬浮红细胞袋的一端口连通，所述悬浮红细胞袋的另一端口通过输血管线与去白悬浮红细胞袋连通，在所述悬浮红细胞袋与去白悬浮红细胞袋之间接设白细胞过滤器，所述压力探测器接头与三通五的侧端口连接，所述血浆袋与离心杯之间的输血管线上接设三通六，所述三通六的侧端口通过输血管线与废液袋连通，所述血浆袋的一端通过输血管线与冷沉淀备用袋连通；Wherein, the disposable whole blood collection and separation device includes blood collection device, sampling bag, bacterial filter, anticoagulant pipeline, anticoagulant puncture device, red blood cell maintenance solution puncture device, saline puncture device, suspended red blood cell bag, white blood cell filter Blood collection device, white suspended red blood cell bag, pressure detector connector, blood pump line, centrifuge cup, plasma bag, cryoprecipitate backup bag and waste liquid bag, said blood collection device, bacterial filter, anticoagulant line and anticoagulant The anticoagulant puncturer is sequentially connected through the blood transfusion line, the blood collection device and the bacterial filter are connected with a three-way one and a three-way two in turn, the lower port of the three-way one is connected with a sampling bag, and the anticoagulant puncturer is connected with the bacterial filter. The anticoagulant pipelines are sequentially connected with a tee three, the side port of the three-way three is connected to the red blood cell maintenance solution puncturer and the saline puncturer respectively through the blood transfusion line, and the upper port of the three-way two is connected through the blood transfusion line. The pipeline is sequentially connected with a blood pump pipeline, a centrifugal cup and a plasma bag, and the blood transfusion line between the three-way two and the blood pump pipeline is connected with a three-way four and a three-way five in sequence, and the side port of the three-way four passes through The blood transfusion line communicates with one port of the suspended red blood cell bag, and the other port of the suspended red blood cell bag communicates with the white-removed suspended red blood cell bag through the blood-transfusion line, and a white blood cell filter is connected between the suspended red blood cell bag and the white-removed suspended red blood cell bag. The pressure detector connector is connected to the side port of the tee five, the blood transfusion line between the plasma bag and the centrifuge cup is connected with the tee six, and the side port of the three joint six is communicated with the waste liquid bag through the blood transfusion line , one end of the plasma bag communicates with the cryoprecipitate backup bag through the blood transfusion line;
所述全血采集分离机包括抗凝剂泵、血泵、离心机、血细胞探测器、管路压力探测器、抗凝剂空气探测器、血液空气探测器、血浆秤和控制器，所述抗凝剂管路接在抗凝剂泵上，所述血泵管路接在血泵上，所述离心杯安装在离心机中，所述血细胞探测器接在离心杯与血浆袋之间的输血管线上，所述压力探测器接头安装在管路压力探测器上，所述抗凝剂空气探测器接在抗凝剂泵管路与三通三之间的输血管线上，所述血液空气探测器接在三通五与离心杯之间的输血管线上，所述血浆袋安装在血浆秤上，所述血细胞探测器、管路压力探测器、抗凝剂空气探测器、血液空气探测器和血浆秤的信号输出端分别与控制器的信号输入端连接，所述控制器的信号输出端分别与抗凝剂泵、血泵和离心机的信号输入端连接。The whole blood collection and separation machine includes an anticoagulant pump, a blood pump, a centrifuge, a blood cell detector, a line pressure detector, an anticoagulant air detector, a blood air detector, a plasma scale and a controller. The coagulant pipeline is connected to the anticoagulant pump, the blood pump pipeline is connected to the blood pump, the centrifuge cup is installed in the centrifuge, and the blood cell detector is connected to the blood transfusion between the centrifuge cup and the plasma bag On the pipeline, the pressure detector connector is installed on the pipeline pressure detector, the anticoagulant air detector is connected to the blood transfusion line between the anticoagulant pump pipeline and the tee, and the blood air detector The device is connected to the blood transfusion line between the tee five and the centrifuge cup, the plasma bag is installed on the plasma scale, the blood cell detector, pipeline pressure detector, anticoagulant air detector, blood air detector and The signal output terminals of the plasma scale are respectively connected with the signal input terminals of the controller, and the signal output terminals of the controller are respectively connected with the signal input terminals of the anticoagulant pump, the blood pump and the centrifuge.
作为优选的技术方案，还包括安装在输血管线上的控制阀，所述控制阀包括阀一、阀二、阀三、阀四、阀五、阀六和阀七，所述三通一和三通二之间的输血管线上接设阀一，所述抗凝剂穿刺器、红细胞保养液穿刺器和盐水穿刺器与输血管线的连接端分别接设阀二、阀三和阀四，所述三通六与血浆袋之间的输血管线上接设阀五，所述三通六与废液袋之间的输血管线上接设阀六，所述三通四与悬浮红细胞袋之间的输血管线上接设阀七，所述控制阀的信号输入端分别与控制器的信号输出端连接。As a preferred technical solution, it also includes a control valve installed on the blood transfusion line, the control valve includes valve one, valve two, valve three, valve four, valve five, valve six and valve seven, the three-way one and three-way Valve 1 is connected to the blood transfusion line between the two, and the connection ends of the anticoagulant puncture device, red blood cell maintenance solution puncture device and saline puncture device and the blood transfusion line are connected with valve 2, valve 3 and valve 4 respectively. The blood transfusion line between the three-way six and the plasma bag is connected with the valve five, the blood transfusion line between the three-way six and the waste liquid bag is connected with the valve six, and the blood transfusion between the three-way four and the suspended red blood cell bag A valve seven is connected to the pipeline, and the signal input ends of the control valves are respectively connected with the signal output ends of the controller.
作为优选的技术方案，所述抗凝剂穿刺器、红细胞保养液穿刺器和盐水穿刺器分别用以向输血管线内输入抗凝剂、红细胞保养液和盐水，其中，抗凝剂通过外设抗凝剂袋存储，抗凝剂袋安装在抗凝剂秤上。As a preferred technical solution, the anticoagulant puncture device, erythrocyte maintenance solution puncture device and saline puncture device are respectively used to input anticoagulant, erythrocyte maintenance solution and saline into the blood transfusion line, wherein the anticoagulant is passed through an external anticoagulant The coagulant bag is stored, and the anticoagulant bag is installed on the anticoagulant scale.
作为优选的技术方案，所述离心杯的容积大小设定采集献血者目标全血的体积为400ml、300ml和200ml。As a preferred technical solution, the volume of the centrifuge cup is set to be 400ml, 300ml and 200ml for the volume of the target whole blood collected from the blood donor.
本发明的有益效果为：The beneficial effects of the present invention are:
1、主要解决现有全血采集到分离制备中，存在过程废时、费力，多场所，成本高；1. It mainly solves the problem of time-consuming, laborious, multi-site and high cost in the existing process of whole blood collection to separation preparation;
2、保证全血离体后，以最快速度分离出新鲜血浆和悬浮红细胞(或洗涤红细胞)，及时冷冻，尽可能降低血浆中的不稳定因子的衰减速度，提高血浆质量，为制备冷沉淀提供条件；2. After the whole blood is isolated from the body, fresh plasma and suspended red blood cells (or washed red blood cells) are separated at the fastest speed, and frozen in time to reduce the attenuation speed of unstable factors in the plasma as much as possible, improve the quality of plasma, and prepare cryoprecipitate provide conditions;
3、减少了分离制备环节中的场所，大容量离心机和血液成分分离机等大型设备、设施，节约成本。3. Reduce the space in the separation and preparation process, large-scale equipment and facilities such as large-capacity centrifuges and blood component separators, and save costs.
附图说明Description of drawings
图1为本发明一种全自动全血采集分离系统的结构框图；Fig. 1 is a block diagram of a fully automatic whole blood collection and separation system of the present invention;
图2为本发明一种全自动全血采集分离系统的结构示意图。Fig. 2 is a schematic structural diagram of an automatic whole blood collection and separation system of the present invention.
图中：1-采血器、2-采样袋、3-细菌过滤器、4-抗凝剂管路、5-抗凝剂穿刺器、6-红细胞保养液穿刺器、7-盐水穿刺器、8-悬浮红细胞袋、9-白细胞过滤器、10-去白悬浮红细胞袋、11-压力探测器接头、12-血泵管路、13-离心杯、14-血浆袋、15-冷沉淀备用袋、16-废液袋、17-三通一、18-三通二、19-三通三、20-三通四、21-三通五、22-三通六、23-抗凝剂泵、24-血泵、25-离心机、26-血细胞探测器、27-管路压力探测器、28-抗凝剂空气探测器、29-血液空气探测器、30-血浆秤、31-控制器、32-抗凝剂秤、33-阀一、34-阀二、35-阀三、36-阀四、37-阀五、38-阀六、39-阀七。In the figure: 1-blood collection device, 2-sampling bag, 3-bacteria filter, 4-anticoagulant pipeline, 5-anticoagulant puncture device, 6-red blood cell maintenance solution puncture device, 7-saline puncture device, 8 -suspension red blood cell bag, 9-white blood cell filter, 10-white blood cell suspension bag, 11-pressure detector connector, 12-blood pump pipeline, 13-centrifugal cup, 14-plasma bag, 15-cryoprecipitate spare bag, 16-Waste liquid bag, 17-Tee one, 18-Tee two, 19-Tee three, 20-Tee four, 21-Tee five, 22-Tee six, 23-Anticoagulant pump, 24 -blood pump, 25-centrifuge, 26-blood cell detector, 27-line pressure detector, 28-anticoagulant air detector, 29-blood air detector, 30-plasma scale, 31-controller, 32 -anticoagulant scale, 33-valve one, 34-valve two, 35-valve three, 36-valve four, 37-valve five, 38-valve six, 39-valve seven.
具体实施方式Detailed ways
为使对本发明的结构特征及所达成的功效有更进一步的了解与认识，用以较佳的实施例及附图配合详细的说明，说明如下：In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings are used for a detailed description, as follows:
如图1～2所示，一种全自动全血采集分离系统，包括全血采集分离机和一次性使用全血采集分离装置，As shown in Figures 1-2, a fully automatic whole blood collection and separation system includes a whole blood collection and separation machine and a disposable whole blood collection and separation device,
其中，一次性全血采集分离装置包括采血器1、采样袋2、细菌过滤器3、抗凝剂管路4、抗凝剂穿刺器5、红细胞保养液穿刺器6、盐水穿刺器7、悬浮红细胞袋8、白细胞过滤器9、去白悬浮红细胞袋10、压力探测器接头11、血泵管路12、离心杯13、血浆袋14、冷沉淀备用袋15和废液袋16，采血器1、细菌过滤器3、抗凝剂管路4和抗凝剂穿刺器5依次通过输血管线连接，采血器1与细菌过滤器3之间依次接有三通一17和三通二18，三通一17的下端口接设采样袋2，抗凝剂穿刺器5与抗凝剂管路4之间依次接有三通三19，三通三19的侧端口通过输血管线分两路分别与红细胞保养液穿刺器6和盐水穿刺器7连接，三通二18的上端口通过输血管线依次接有血泵管路12、离心杯13和血浆袋14，三通二18与血泵管路12之间的输血管线上依次接有三通四20和三通五21，三通四20的侧端口通过输血管线与悬浮红细胞袋8的一端口连通，悬浮红细胞袋8的另一端口通过输血管线与去白悬浮红细胞袋10连通，在悬浮红细胞袋8与去白悬浮红细胞袋10之间接设白细胞过滤器9，压力探测器接头11与三通五21的侧端口连接，血浆袋14与离心杯13之间的输血管线上接设三通六22，三通六22的侧端口通过输血管线与废液袋16连通，血浆袋14的一端通过输血管线与冷沉淀备用袋15连通；Among them, the disposable whole blood collection and separation device includes a blood collection device 1, a sampling bag 2, a bacterial filter 3, an anticoagulant pipeline 4, an anticoagulant puncture device 5, a red blood cell maintenance solution puncture device 6, a saline puncture device 7, a suspension Red blood cell bag 8, white blood cell filter 9, white blood cell bag 10, pressure detector connector 11, blood pump line 12, centrifuge cup 13, plasma bag 14, cryoprecipitate backup bag 15 and waste liquid bag 16, blood collection device 1 , bacterial filter 3, anticoagulant pipeline 4 and anticoagulant puncturer 5 are connected through the blood transfusion line in turn, and there are three links one 17 and three links two 18 successively between the blood collection device 1 and the bacterial filter 3, three links one The lower port of 17 is connected with a sampling bag 2, the anticoagulant puncturer 5 and the anticoagulant pipeline 4 are connected with a three-way three 19 in turn, and the side port of the three-way three 19 is divided into two ways through the blood transfusion line to be connected with the red blood cell maintenance solution respectively. The puncturer 6 is connected with the saline puncturer 7, and the upper port of the tee 2 18 is sequentially connected with the blood pump line 12, the centrifugal cup 13 and the plasma bag 14 through the blood transfusion line, and the connection between the tee 2 18 and the blood pump line 12 The blood transfusion line is sequentially connected with a three-way four 20 and a three-way five 21. The side port of the three-way four 20 is connected with one port of the suspended red blood cell bag 8 through the blood transfusion line, and the other port of the suspended red blood cell bag 8 is connected with the white suspension through the blood transfusion line. The red blood cell bag 10 is connected, and the leukocyte filter 9 is directly set between the suspended red blood cell bag 8 and the white-removed suspended red blood cell bag 10. The pressure detector joint 11 is connected to the side port of the tee five 21. The blood transfusion line is connected with a tee 6 22, and the side port of the tee 22 is communicated with the waste liquid bag 16 through the blood transfusion line, and one end of the plasma bag 14 is communicated with the cryoprecipitate standby bag 15 through the blood transfusion line;
全血采集分离机包括抗凝剂泵23、血泵24、离心机25、血细胞探测器26、管路压力探测器27、抗凝剂空气探测器28、血液空气探测器29、控制器31和血浆秤30，抗凝剂管路4接在抗凝剂泵23上，血泵管路12接在血泵24上，离心杯13安装在离心机25中，血细胞探测器26接在离心杯13与血浆袋14之间的输血管线上，压力探测器接头11安装在管路压力探测器27上，抗凝剂空气探测器28接在抗凝剂泵管路4与三通三19之间的输血管线上，血液空气探测器29接在三通五21与离心杯13之间的输血管线上，血浆袋14安装在血浆秤30上，血细胞探测器26、管路压力探测器27、抗凝剂空气探测器28、血液空气探测器29和血浆秤30的信号输出端分别与控制器31的信号输入端连接，控制器31的信号输出端分别与抗凝剂泵23、血泵24和离心机25的信号输入端连接。The whole blood collection and separation machine comprises an anticoagulant pump 23, a blood pump 24, a centrifuge 25, a blood cell detector 26, a pipeline pressure detector 27, an anticoagulant air detector 28, a blood air detector 29, a controller 31 and Plasma scale 30, the anticoagulant pipeline 4 is connected to the anticoagulant pump 23, the blood pump pipeline 12 is connected to the blood pump 24, the centrifuge cup 13 is installed in the centrifuge 25, and the blood cell detector 26 is connected to the centrifuge cup 13 On the blood transfusion line between the plasma bag 14, the pressure detector connector 11 is installed on the pipeline pressure detector 27, and the anticoagulant air detector 28 is connected to the anticoagulant pump pipeline 4 and the tee three 19. On the blood transfusion line, the blood air detector 29 is connected to the blood transfusion line between the tee five 21 and the centrifuge cup 13, the plasma bag 14 is installed on the plasma scale 30, the blood cell detector 26, the line pressure detector 27, the anticoagulant The signal output ends of the agent air detector 28, the blood air detector 29 and the plasma scale 30 are respectively connected with the signal input ends of the controller 31, and the signal output ends of the controller 31 are connected with the anticoagulant pump 23, the blood pump 24 and the centrifuge respectively. The signal input terminal of machine 25 is connected.
在本实施例中，还包括安装在输血管线上的控制阀，控制阀包括阀一33、阀二34、阀三35、阀四36、阀五37、阀六38和阀七39，三通一17和三通二18之间的输血管线上接设阀一33，抗凝剂穿刺器5、红细胞保养液穿刺器6和盐水穿刺器7与输血管线的连接端分别接设阀二34、阀三35和阀四36，三通六22与血浆袋14之间的输血管线上接设阀五37，三通六22与废液袋16之间的输血管线上接设阀六38，三通四20与悬浮红细胞袋8之间的输血管线上接设阀七39，控制阀的信号输入端分别与控制器31的信号输出端连接。In this embodiment, it also includes a control valve installed on the blood transfusion line. The control valve includes valve one 33, valve two 34, valve three 35, valve four 36, valve five 37, valve six 38 and valve seven 39, three-way Valve one 33 is connected to the blood transfusion line between one 17 and tee two 18, and valve two 34, Valve three 35 and valve four 36, valve five 37 are connected on the transfusion line between three-way six 22 and plasma bag 14, and valve six 38 and three-way are connected on the transfusion line between three-way six 22 and waste liquid bag 16. A valve 7 39 is connected to the blood transfusion line between the passage 4 20 and the suspended red blood cell bag 8 , and the signal input ends of the control valves are respectively connected with the signal output ends of the controller 31 .
在本实施例中，抗凝剂穿刺器5、红细胞保养液穿刺器6和盐水穿刺器7分别用以向输血管线内输入抗凝剂、红细胞保养液和盐水，其中，抗凝剂通过外设抗凝剂袋存储，抗凝剂袋安装在抗凝剂秤32上。In this embodiment, the anticoagulant puncture device 5, the erythrocyte maintenance solution puncture device 6 and the saline puncture device 7 are respectively used to input anticoagulant, red blood cell maintenance solution and saline into the blood transfusion line, wherein the anticoagulant passes through the peripheral The anticoagulant bag is stored, and the anticoagulant bag is installed on the anticoagulant scale 32 .
在本实施例中，离心杯13的容积大小设定采集献血者目标全血的体积为400ml、300ml和200ml。In this embodiment, the volume of the centrifuge cup 13 is set to be 400ml, 300ml and 200ml for the target whole blood collected from the blood donor.
在本实施例中，本系统的工作原理为：采血器1上穿刺针穿刺献血者前臂静脉成功后，开启全血采集分离机，离心机25带动离心杯13开始运行，抗凝剂泵23和血泵24顺时针转动工作，与此同时，控制器31打开阀一33、阀二34、阀五37和阀六38，其余阀关闭；献血者的全血进入输血管线中，抗凝剂在三通二18处与抽取的全血液混合后形成抗凝全血，再通过三通四20和三通五21由血泵24送入离心杯13中进行离心分离，分离后的得到新鲜血浆进入血浆袋14中；根据血泵24的转数测定采集献血者定量全血和血浆秤30测定分离定量血浆完成之后，血液采集停止，抗凝剂泵23和血泵24停止运转，所有阀关闭，离心机25刹车；待离心机25停止，抗凝剂泵23顺时针转动，血泵24逆时针转动，阀七39、阀五37和阀二34打开，其余阀关闭，此时离心杯13中除血浆以外的其他血液成分和红细胞保存液，进入至悬浮红细胞袋8中，进而再通过白细胞过滤器9过滤至去白悬浮红细胞袋10中，制备成去白细胞悬浮红细胞；如需制备洗涤红细胞，则是在血液采集停止后，离心机25继续运行，抗凝剂泵23和血泵24顺时针转动，阀六38和阀四36打开，其余阀关闭，盐水通过抗凝剂泵23和血泵24进入离心杯13，置换出离心杯13中几乎所有血浆成分和部分非红细胞成分，并将其排放至废液袋中，然后重复上述悬浮红细胞制备过程，可制备成洗涤红细胞。In this embodiment, the working principle of this system is: after the puncture needle on the blood collection device 1 successfully punctures the blood donor's forearm vein, the whole blood collection and separator is turned on, the centrifuge 25 drives the centrifugal cup 13 to start running, and the anticoagulant pump 23 and The blood pump 24 rotates clockwise to work, at the same time, the controller 31 opens valve one 33, valve two 34, valve five 37 and valve six 38, and other valves are closed; the whole blood of the blood donor enters the transfusion line, and the anticoagulant is Three links 2 18 are mixed with the extracted whole blood to form anticoagulant whole blood, and then sent to the centrifuge cup 13 by blood pump 24 through three links 4 20 and 3 links 5 21 for centrifugation, and fresh plasma obtained after separation enters In the plasma bag 14; according to the number of revolutions of the blood pump 24, the quantitative whole blood of the blood donor is collected and the plasma scale 30 measures the separation and quantitative plasma. After the blood collection is completed, the blood collection stops, the anticoagulant pump 23 and the blood pump 24 stop running, and all valves are closed. The centrifuge 25 brakes; when the centrifuge 25 stops, the anticoagulant pump 23 rotates clockwise, the blood pump 24 rotates counterclockwise, valve seven 39, valve five 37 and valve two 34 are opened, and other valves are closed. Other blood components and red blood cell preservation solution except plasma enter into the suspended red blood cell bag 8, and then filter through the white blood cell filter 9 into the white blood cell suspension bag 10 to prepare leukocyte-free suspended red blood cells; if it is necessary to prepare washed red blood cells, After the blood collection is stopped, the centrifuge 25 continues to run, the anticoagulant pump 23 and the blood pump 24 rotate clockwise, the valve six 38 and the valve four 36 are opened, and the other valves are closed, and the saline passes through the anticoagulant pump 23 and the blood pump 24 enters the centrifuge cup 13, replaces almost all plasma components and some non-erythrocyte components in the centrifuge cup 13, and discharges them into the waste liquid bag, and then repeats the above-mentioned suspension erythrocyte preparation process, which can be prepared into washed erythrocytes.
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是本发明的原理，在不脱离本发明精神和范围的前提下本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明的范围内。本发明要求的保护范围由所附的权利要求书及其等同物界定。The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the art should understand that the present invention is not limited by the above-mentioned embodiments. What are described in the above-mentioned embodiments and the description are only the principles of the present invention. Variations and improvements, which fall within the scope of the claimed invention. The scope of protection required by the present invention is defined by the appended claims and their equivalents.
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| CN110215217A (en) * | 2019-06-05 | 2019-09-10 | 四川南格尔生物科技有限公司 | A kind of sampled plasma system and method |
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| CN111436955A (en) * | 2019-12-16 | 2020-07-24 | 成都市佳颖医用制品有限公司 | Blood collection and separation device and control system |
| CN111436949A (en) * | 2020-04-23 | 2020-07-24 | 青岛市中心血站 | Blood sampling station is with painless formula of drag reduction self-service blood collection device |
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