CN108524569A - 三七鲜提真空干燥粉末饮片 - Google Patents
三七鲜提真空干燥粉末饮片 Download PDFInfo
- Publication number
- CN108524569A CN108524569A CN201810733378.0A CN201810733378A CN108524569A CN 108524569 A CN108524569 A CN 108524569A CN 201810733378 A CN201810733378 A CN 201810733378A CN 108524569 A CN108524569 A CN 108524569A
- Authority
- CN
- China
- Prior art keywords
- decoction
- radix notoginseng
- fresh
- water
- vacuum drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 19
- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 title claims abstract description 9
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 13
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 claims description 3
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 229930189092 Notoginsenoside Natural products 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 description 2
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 description 2
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公布了一种“三七鲜提真空干燥粉末饮片”，其主要特征在于：在三七采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩成清膏后，再真空干燥至含水量少于10%，粉碎、过筛后真空包装。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、胶囊剂，利于携带，临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域，尤其属于三七饮片的加工领域。
背景技术
中药三七为五加科植物三七Panax notoginseng（Burk.）F.H.Chen的干燥根和根茎。秋季花开前采挖，具有散瘀止血，消肿定痛的功效。主要用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹刺痛，跌扑肿痛等的治疗，是中医临床上常见的一味中药。传统三七的加工方法为：将药材采挖后，洗净，分开主根、支根及根茎，干燥，打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。此类饮片体积大，卫生学标准差，易于受潮、长霉，不利于保管，储存和运输成本高。此外，这样的三七饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型三七饮片，势在必行。目前市场上的三七饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“三七鲜提真空干燥粉末饮片”，其主要特征在于：在三七采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏。将所得的清膏在60~80℃下真空干燥至含水量低于10%，粉碎，过60目筛，真空包装，即得成品。成品饮片含人参皂苷Rg1（C42H72O14）、人参皂苷Rb1（C54H92O23）及三七皂苷R1（C47H80O18）的总量不少于6.0%。本三七饮片临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统三七饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将三七药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.20的清膏。将所得的清膏于80℃下真空干燥至含水量为8%，粉碎，过60目筛，真空包装，即得成品。成品饮片含人参皂苷Rg1（C42H72O14）、人参皂苷Rb1（C54H92O23）及三七皂苷R1（C47H80O18）的总量为7.0%。
Claims (2)
1.一种三七鲜提真空干燥粉末饮片，其主要特征在于：在三七采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏；将所得的清膏在60~80℃下真空干燥至含水量低于10%，粉碎，过60目筛，真空包装，即得成品；成品饮片含人参皂苷Rg1（C42H72O14）、人参皂苷Rb1（C54H92O23）及三七皂苷R1（C47H80O18）的总量不少于6.0%。
2.根据权利要求1所述的三七鲜提真空干燥粉末饮片，其主要特征在于：临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733378.0A CN108524569A (zh) | 2018-07-06 | 2018-07-06 | 三七鲜提真空干燥粉末饮片 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733378.0A CN108524569A (zh) | 2018-07-06 | 2018-07-06 | 三七鲜提真空干燥粉末饮片 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108524569A true CN108524569A (zh) | 2018-09-14 |
Family
ID=63487663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733378.0A Pending CN108524569A (zh) | 2018-07-06 | 2018-07-06 | 三七鲜提真空干燥粉末饮片 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108524569A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110624645A (zh) * | 2018-09-21 | 2019-12-31 | 云南崔三七药业股份有限公司 | 一种三七皂苷的制备工艺 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362182A (zh) * | 2017-08-25 | 2017-11-21 | 徐漫 | 一种凤尾草鲜榨真空干燥粉末饮片的制备工艺 |
| CN107412303A (zh) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | 一种佩兰鲜榨真空干燥粉末饮片的制备工艺 |
| CN107432883A (zh) * | 2017-08-25 | 2017-12-05 | 徐漫 | 一种透骨草鲜榨真空干燥粉末饮片的制备工艺 |
| CN107582624A (zh) * | 2017-08-25 | 2018-01-16 | 徐自升 | 一种广藿香鲜榨真空干燥粉末饮片的制备工艺 |
| CN108186690A (zh) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | 一种中药材处理方法 |
-
2018
- 2018-07-06 CN CN201810733378.0A patent/CN108524569A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362182A (zh) * | 2017-08-25 | 2017-11-21 | 徐漫 | 一种凤尾草鲜榨真空干燥粉末饮片的制备工艺 |
| CN107412303A (zh) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | 一种佩兰鲜榨真空干燥粉末饮片的制备工艺 |
| CN107432883A (zh) * | 2017-08-25 | 2017-12-05 | 徐漫 | 一种透骨草鲜榨真空干燥粉末饮片的制备工艺 |
| CN107582624A (zh) * | 2017-08-25 | 2018-01-16 | 徐自升 | 一种广藿香鲜榨真空干燥粉末饮片的制备工艺 |
| CN108186690A (zh) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | 一种中药材处理方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110624645A (zh) * | 2018-09-21 | 2019-12-31 | 云南崔三七药业股份有限公司 | 一种三七皂苷的制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108524569A (zh) | 三七鲜提真空干燥粉末饮片 | |
| CN108619198A (zh) | 三七鲜提喷雾干燥粉末饮片 | |
| CN108635388A (zh) | 三七鲜提喷雾干燥颗粒饮片 | |
| CN108619209A (zh) | 板蓝根鲜提真空干燥粉末饮片 | |
| CN108553519A (zh) | 白芍鲜提冷冻干燥颗粒饮片 | |
| CN108671006A (zh) | 党参鲜提真空干燥粉末饮片 | |
| CN108619196A (zh) | 三七鲜提冷冻干燥粉末饮片 | |
| CN108567804A (zh) | 西洋参鲜提真空干燥粉末饮片 | |
| CN108619231A (zh) | 丹参鲜提喷雾干燥粉末饮片 | |
| CN108671023A (zh) | 丹参鲜提真空干燥粉末饮片 | |
| CN108619223A (zh) | 黄芪鲜提真空干燥粉末饮片 | |
| CN108619458A (zh) | 莪术鲜提真空干燥粉末饮片 | |
| CN108619189A (zh) | 川芎鲜提真空干燥粉末饮片 | |
| CN108671069A (zh) | 地黄鲜提真空干燥粉末饮片 | |
| CN108771748A (zh) | 莪术鲜提喷雾干燥粉末饮片 | |
| CN108619397A (zh) | 天麻鲜提真空干燥粉末饮片 | |
| CN108524657A (zh) | 地黄鲜提喷雾干燥粉末饮片 | |
| CN108619368A (zh) | 知母鲜提真空干燥粉末饮片 | |
| CN108771696A (zh) | 西洋参鲜提喷雾干燥粉末饮片 | |
| CN108619224A (zh) | 甘草鲜提真空干燥粉末饮片 | |
| CN108619194A (zh) | 西洋参鲜提冷冻干燥粉末饮片 | |
| CN108619222A (zh) | 黄芪鲜提冷冻干燥粉末饮片 | |
| CN108498567A (zh) | 黄芪鲜提冷冻干燥颗粒饮片 | |
| CN108671042A (zh) | 黄连鲜提真空干燥粉末饮片 | |
| CN108524559A (zh) | 牛膝鲜提真空干燥粉末饮片 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180914 |