CN108498065B - A kind of lacrimal duct tear pump drainage function detector and detection method thereof - Google Patents
A kind of lacrimal duct tear pump drainage function detector and detection method thereof Download PDFInfo
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- 238000001514 detection method Methods 0.000 title abstract description 7
- 239000013307 optical fiber Substances 0.000 claims abstract description 46
- 238000004458 analytical method Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 230000003287 optical effect Effects 0.000 claims abstract description 7
- 239000011521 glass Substances 0.000 claims description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 17
- 239000000741 silica gel Substances 0.000 claims description 17
- 229910002027 silica gel Inorganic materials 0.000 claims description 17
- 239000013078 crystal Substances 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 4
- 230000010363 phase shift Effects 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 2
- 230000010287 polarization Effects 0.000 claims 1
- 238000010998 test method Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 abstract description 7
- 238000013461 design Methods 0.000 description 4
- 241000909851 Epiphora Species 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000016747 lacrimal apparatus disease Diseases 0.000 description 3
- 238000005259 measurement Methods 0.000 description 2
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 241000083513 Punctum Species 0.000 description 1
- 230000007488 abnormal function Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
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- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/22—Ergometry; Measuring muscular strength or the force of a muscular blow
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Abstract
本发明涉及一种泪道泪液泵引流功能检测仪及其检测方法，包括有光纤压力传感器、光纤压力传感解调器，由光纤压力传感器将检测的信号传送给光纤压力传感解调器；选取面阵CCD中心一行作为水平维度低相干干涉信号，采用空间频域分析法对水平维度上的干涉信号进行解调；根据初步结果对应像元所在列的干涉信号进行提取，采用相移法与包络峰值相结合的方法对垂直维度上精细采样信号进行解调；将解调器得出的光学数据转化为压力值，并随时间的推移转化为压力变化曲线。采用上述技术方案，本发明提供了一种泪道泪液泵引流功能检测仪及其检测方法，其可以通过检测泪小管、泪囊内随眼睑启闭的压力变化曲线值，通过后台程序分析泪道泪液泵引流功能。
The invention relates to a lacrimal duct tear pump drainage function detector and a detection method thereof, comprising an optical fiber pressure sensor and an optical fiber pressure sensing demodulator, and the optical fiber pressure sensor transmits the detected signal to the optical fiber pressure sensing demodulator; Select the center row of the area array CCD as the low-coherence interference signal in the horizontal dimension, and use the spatial frequency domain analysis method to demodulate the interference signal in the horizontal dimension; The combined method of envelope peaking demodulates a finely sampled signal in the vertical dimension; converts the optical data from the demodulator into pressure values and into a pressure curve over time. By adopting the above technical solutions, the present invention provides a lacrimal duct tear pump drainage function detector and a detection method thereof, which can analyze the lacrimal duct through a background program by detecting the pressure change curve value in the lacrimal canaliculus and lacrimal sac with the opening and closing of the eyelid. Tear pump drainage function.
Description
Technical Field
The invention relates to a lacrimal passage tear pump drainage function detector and a detection method thereof.
Background
Lacrimation is a common symptom of ophthalmology, and is caused by organic obstruction of the lacrimal passage and abnormal function of the tear pump. Therefore, a disease called 'functional epiphora' often appears clinically, which is usually a smooth lacrimal passage and abnormal lacrimal drainage function, and then the epiphora phenomenon appears. The realization of the lacrimal drainage function requires that the pressure of each section of lacrimal passage is orderly changed along with the opening and closing of the eyelid, namely a lacrimal canaliculus pump mechanism. When the eyelids are closed, the lacrimal canaliculus is contracted, the lacrimal punctum is closed and moves to the nasal side, positive pressure is formed in the lacrimal canaliculus, and tears enter the lacrimal sac; when the eyelid is opened, the opening of the lacrimal canaliculus is closed instantaneously, negative pressure is formed in the lacrimal canaliculus, and tears are sucked into the lacrimal canaliculus to enter the next circulation. Therefore, the functional patients with epiphora cannot form negative pressure or insufficient negative pressure in the lacrimal canaliculus during the eyelid opening, or the positive pressure is insufficient during the eyelid closing, which leads to abnormal tear drainage. Dynamic monitoring of lacrimal canaliculus pressure is therefore a key to diagnosing abnormalities in tear drainage function.
Disclosure of Invention
The purpose of the invention is as follows: in order to overcome the defects of the prior art, the invention provides a lacrimal passage tear pump drainage function detector which can analyze the drainage function of the lacrimal passage tear pump through a background program by detecting the pressure change curve values of the lacrimal canaliculus and the lacrimal sac along with the opening and closing of the eyelids.
The technical scheme of the invention is as follows: the utility model provides a lacrimal passage tear pump drainage function detector which characterized in that: the device comprises an optical fiber pressure sensor and an optical fiber pressure sensing demodulator, wherein the optical fiber pressure sensor is connected with the optical fiber pressure sensing demodulator; the optical fiber pressure sensor comprises glass, wherein a concave cavity is formed in one end of the glass, a collimator is arranged at the other end of the glass, the concave cavity is opened, a diaphragm is arranged on the glass corresponding to the opening of the concave cavity, and the periphery of the diaphragm is connected with the glass on two sides of the concave cavity; the optical fiber pressure sensing demodulator comprises a collimating lens, a polarizer, a birefringent crystal, an analyzer and an area array CCD which are sequentially arranged at intervals.
By adopting the technical scheme, the external pressure acts on the diaphragm, the external pressure is sensed by utilizing the length change of the concave cavity caused by the elastic deformation of the diaphragm, then the demodulation is carried out by the optical fiber pressure sensing demodulator, finally, the optical analysis data obtained by the high-precision optical fiber pressure sensing demodulator can be converted into the pressure value by utilizing the data analyzer, the pressure value is converted into the pressure change curve taking the time as the horizontal axis along with the time, and then the feasibility analysis of the abnormal pressure of the lacrimal passage is obtained by comparing the pressure change curve with the normal data.
The invention further comprises the following steps: and a silica gel sleeve is also coated outside the optical fiber pressure sensor.
Adopt above-mentioned further setting, coupling efficiency and stability that light signal can be guaranteed to the silica gel cover.
The invention further provides that: the length of the silica gel sleeve is 9-11cm, wherein the length of the silica gel sleeve corresponding to the position of the collimator is 3.5-4.5 cm.
By adopting the above further arrangement, the optical fiber pressure sensor can be implanted into the lacrimal passage, and can be conveniently held by hands during implantation, and the operation is convenient.
Still further arrangements of the invention are: the thickness of the silica gel sleeve corresponding to the collimator is 0.08-0.12mm, and the thickness of the silica gel sleeve corresponding to the glass is 0.28-0.32 mm.
By adopting the above further arrangement, the thickness and the volume of the optical fiber coupler can be reduced as much as possible while the coupling efficiency and the stability of the optical signal are ensured.
Still further arrangements of the invention are: and a boss is arranged in the middle of one side of the membrane facing the concave cavity.
By adopting the above further arrangement, in order to realize high-sensitivity sensing of lacrimal canaliculus pressure, the diaphragm needs to generate larger deformation in the pressure measurement range, and the arranged boss can avoid the influence of the intensity change when the reflected light beam at the diaphragm end is coupled back to the optical fiber to the contrast of the interference signal generated by the sensor.
Still further arrangements of the invention are: the double-refraction crystal is a hexahedron and comprises a front vertical surface, a rear vertical surface, an upper horizontal surface, a lower horizontal surface, a left vertical surface and a right inclined surface, wherein the right inclined surface is obliquely arranged with the front vertical surface and the rear vertical surface, and the right inclined surface is close to one side of the analyzer.
By adopting the above further arrangement, the right inclined plane can enlarge the measurement range through large-angle design in the horizontal dimension, and realize hyperfine acquisition of local signals through small-angle design in the vertical dimension.
The invention also provides a detection method of the lacrimal passage tear fluid pump drainage function detector, which can obtain feasibility analysis of lacrimal passage pressure abnormity by detecting the pressure change of lacrimal canaliculus, and comprises the following steps:
(1) the optical fiber pressure sensor transmits the detected signal to the optical fiber pressure sensing demodulator;
(2) during demodulation, selecting one line of the center of the area array CCD as a horizontal dimension low-coherence interference signal, and demodulating the interference signal on the horizontal dimension by adopting a space frequency domain analysis method after noise reduction processing to obtain a preliminary demodulation result;
(3) extracting interference signals of a row where pixels corresponding to the preliminary result are located, denoising the interference signals, and demodulating fine sampling signals in a vertical dimension by adopting a method of combining a phase shift method and an envelope peak value to obtain a high-precision demodulation result;
(4) and converting the optical analysis data obtained by the high-precision optical fiber pressure sensing demodulator into a pressure value by using a data analyzer, and converting the pressure value into a pressure change curve taking time as a horizontal axis along with the time.
By adopting the technical scheme, the feasibility analysis of the lacrimal passage pressure abnormity can be obtained only by comparing the obtained pressure change curve with normal data.
Still further arrangements of the invention are: and (3) introducing a dispersion compensation optical fiber in the steps (2) and (3).
By adopting the further setting, the influence of chromatic dispersion on demodulation can be avoided, and the accuracy of the demodulation data is ensured.
Drawings
FIG. 1 is a schematic block diagram of a specific embodiment of the present invention;
FIG. 2 is a block diagram of an optical fiber pressure sensor in an embodiment of the present invention;
fig. 3 is a structural diagram of an optical fiber pressure sensing demodulator according to an embodiment of the present invention.
Detailed Description
As shown in fig. 1-3, a lacrimal passage tear pump drainage function detector comprises an optical fiber pressure sensor 1 and an optical fiber pressure sensing demodulator 2, wherein the optical fiber pressure sensor 1 is connected with the optical fiber pressure sensing demodulator 2 through an optical fiber; the optical fiber pressure sensor 1 comprises glass 11, a cavity 111 is arranged at one end of the glass 11, a collimator 12 is arranged at the other end of the glass 11, the cavity 111 is provided with an opening, a diaphragm 13 is arranged on the glass 11 corresponding to the opening of the cavity 111, and the periphery of the diaphragm 13 is fixedly connected with the glass on two sides of the cavity 111; the optical fiber pressure sensing demodulator 2 comprises a collimating lens 21, a polarizer 22, a birefringent crystal 23, an analyzer 24 and an area array CCD25 which are sequentially arranged at intervals, wherein the birefringent crystal 23 is hexahedron and comprises a front vertical surface 231, a rear vertical surface 232, an upper horizontal surface 233, a lower horizontal surface 234, a left vertical surface 235 and a right inclined surface 236, the right inclined surface 236 is obliquely arranged with the front vertical surface 231 and the rear vertical surface 232, the right inclined surface 236 is close to one side of the analyzer 24, the right inclined surface can enlarge the measurement range through large-angle design in the horizontal dimension, and hyperfine collection of local signals is realized through small-angle design in the vertical dimension.
In the specific embodiment of the invention, the optical fiber pressure sensor 1 is further coated with a disposable silica gel sleeve 14, and the silica gel sleeve 14 can ensure the coupling efficiency and stability of optical signals; the length of the silica gel sleeve 14 is 9-11cm, wherein the length of the position of the silica gel sleeve 14 corresponding to the collimator 12 is 3.5-4.5 cm; the thickness of the silica gel sleeve 14 corresponding to the collimator 12 is 0.08-0.12mm, and the thickness of the silica gel sleeve 14 corresponding to the glass 11 is 0.28-0.32 mm.
In addition, the middle of the diaphragm 13 facing the cavity is provided with a boss 131. Because the high sensitivity sensing of the lacrimal canaliculus pressure needs to be realized, the diaphragm generates a larger deformation amount in the pressure measuring range, and the arranged boss 131 can avoid the intensity change when the reflected light beam at the diaphragm end is coupled back to the optical fiber, so that the contrast of the interference signal generated by the sensor is influenced.
The detection method of the lacrimal passage tear pump drainage function detector comprises the following steps:
(1) the optical fiber pressure sensor transmits the detected optical fiber signal to the optical fiber pressure sensing demodulator;
(2) during demodulation, selecting one line of the center of the area array CCD as a horizontal dimension low-coherence interference signal, and demodulating the interference signal on the horizontal dimension by adopting a space frequency domain analysis method after noise reduction processing to obtain a preliminary demodulation result;
(3) extracting interference signals of a row where pixels corresponding to the preliminary result are located, denoising the interference signals, and demodulating fine sampling signals in a vertical dimension by adopting a method of combining a phase shift method and an envelope peak value to obtain a high-precision demodulation result;
(4) the optical analysis data obtained by the high-precision optical fiber pressure sensing demodulator is converted into a pressure value by using a data analyzer, the pressure value is converted into a pressure change curve taking time as a horizontal axis along with the time, and the obtained pressure change curve is compared with normal data, so that the feasibility analysis of the lacrimal passage pressure abnormity can be obtained.
In addition, the dispersion compensation fiber is introduced in the steps (2) and (3), so that the influence of dispersion on demodulation can be avoided, and the accuracy of the demodulated data is ensured.
Claims (5)
1. The utility model provides a lacrimal passage tear pump drainage function detector which characterized in that: the device comprises an optical fiber pressure sensor and an optical fiber pressure sensing demodulator, wherein the optical fiber pressure sensor is connected with the optical fiber pressure sensing demodulator; the optical fiber pressure sensor comprises glass, wherein a concave cavity is formed in one end of the glass, a collimator is arranged at the other end of the glass, the concave cavity is opened, a diaphragm is arranged on the glass corresponding to the opening of the concave cavity, and the periphery of the diaphragm is connected with the glass on two sides of the concave cavity; the optical fiber pressure sensing demodulator comprises a collimating lens, a polarizer, a birefringent crystal, a polarization analyzer and an area array CCD which are sequentially arranged at intervals, wherein the optical fiber pressure sensor is further coated with a silica gel sleeve, the length of the silica gel sleeve is 9-11cm, the length of the silica gel sleeve corresponding to the position of the collimator is 3.5-4.5cm, the thickness of the silica gel sleeve corresponding to the position of the collimator is 0.08-0.12mm, and the thickness of the silica gel sleeve corresponding to the position of the glass is 0.28-0.32 mm.
2. The lacrimal passage tear fluid pump drainage function detector of claim 1, wherein: and a boss is arranged in the middle of one side of the membrane facing the concave cavity.
3. The lacrimal passage tear pump drainage function detector of claim 2, wherein: the double-refraction crystal is a hexahedron and comprises a front vertical surface, a rear vertical surface, an upper horizontal surface, a lower horizontal surface, a left vertical surface and a right inclined surface, wherein the right inclined surface is obliquely arranged with the front vertical surface and the rear vertical surface, and the right inclined surface is close to one side of the analyzer.
4. A method of testing using the lacrimal passage tear fluid pump drainage function test instrument of claim 1, comprising the steps of:
(1) the optical fiber pressure sensor transmits the detected signal to the optical fiber pressure sensing demodulator;
(2) during demodulation, selecting one line of the center of the area array CCD as a horizontal dimension low-coherence interference signal, and demodulating the interference signal on the horizontal dimension by adopting a space frequency domain analysis method after noise reduction processing to obtain a preliminary demodulation result;
(3) extracting interference signals of a row where pixels corresponding to the preliminary result are located, denoising the interference signals, and demodulating fine sampling signals in a vertical dimension by adopting a method of combining a phase shift method and an envelope peak value to obtain a high-precision demodulation result;
(4) and converting the optical analysis data obtained by the high-precision optical fiber pressure sensing demodulator into a pressure value by using a data analyzer, and converting the pressure value into a pressure change curve taking time as a horizontal axis along with the time.
5. The method of claim 4, wherein the method comprises the steps of: and (3) introducing a dispersion compensation optical fiber in the steps (2) and (3).
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103528735A (en) * | 2013-10-31 | 2014-01-22 | 南京信息工程大学 | Miniature optical fiber Fabry-Perot pressure sensor and manufacturing method thereof |
| CN105466621A (en) * | 2015-12-28 | 2016-04-06 | 天津大学 | High resolution polarization low-coherence interferometry pressure measurement device and method |
| CN106323515A (en) * | 2015-07-10 | 2017-01-11 | 成都凯天电子股份有限公司 | Optical fiber F-P cavity stress relief pressure sensor |
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| US7689071B2 (en) * | 2004-12-22 | 2010-03-30 | Opsens Inc. | Fiber optic pressure sensor for catheter use |
| GB2500256B (en) * | 2012-03-16 | 2016-12-21 | Oxsensis Ltd | Optical pressure sensor |
| CN205607568U (en) * | 2016-02-23 | 2016-09-28 | 成都凯天电子股份有限公司 | Integral type optic fibre F -P chamber pressure sensor |
| US9839749B2 (en) * | 2016-04-27 | 2017-12-12 | Novartis Ag | Intraocular pressure sensing systems, devices, and methods |
| CN106338352A (en) * | 2016-09-19 | 2017-01-18 | 电子科技大学 | Optical fiber pressure sensor of inaction contact angle measurement error |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103528735A (en) * | 2013-10-31 | 2014-01-22 | 南京信息工程大学 | Miniature optical fiber Fabry-Perot pressure sensor and manufacturing method thereof |
| CN106323515A (en) * | 2015-07-10 | 2017-01-11 | 成都凯天电子股份有限公司 | Optical fiber F-P cavity stress relief pressure sensor |
| CN105466621A (en) * | 2015-12-28 | 2016-04-06 | 天津大学 | High resolution polarization low-coherence interferometry pressure measurement device and method |
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