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CN108492874A - The critical value diagnosis and therapy system of intelligence - Google Patents

The critical value diagnosis and therapy system of intelligence Download PDF

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Publication number
CN108492874A
CN108492874A CN201810404112.1A CN201810404112A CN108492874A CN 108492874 A CN108492874 A CN 108492874A CN 201810404112 A CN201810404112 A CN 201810404112A CN 108492874 A CN108492874 A CN 108492874A
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critical value
library
positive
data
negative
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文耀锋
包勇
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Jiangsu Medical Image Information Technology Co Ltd
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Jiangsu Medical Image Information Technology Co Ltd
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F40/00Handling natural language data
    • G06F40/20Natural language analysis
    • G06F40/279Recognition of textual entities
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V40/00Recognition of biometric, human-related or animal-related patterns in image or video data
    • G06V40/10Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands

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  • Computational Linguistics (AREA)
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Abstract

The present invention provides a kind of critical value diagnosis and therapy systems of intelligence, including critical value screening module and critical value transfer module, wherein:Critical value screening module establishes critical Value Data library, and the critical Value Data library is trained and is verified, and obtains critical value-based algorithm;Critical Value Data library is divided into critical value positive data library and the negative database of critical value by critical value screening module, and critical value positive data library is randomly divided into positive training library and positive verification library by a certain percentage, the negative database of critical value is randomly divided into negative training library and negative verification library by a certain percentage, critical value-based algorithm is trained using positive training library and negative training library, critical value-based algorithm is verified using positive verification library and negative verification library;It checks whether the data of radiology image and radiology report have critical illness by the critical value-based algorithm, if having critical illness, and starts warning device after being verified, and clinician is sent to by the critical value transfer module.

Description

The critical value diagnosis and therapy system of intelligence
Technical field
The present invention relates to field of artificial intelligence, more particularly to a kind of critical value diagnosis and therapy system of intelligence.
Background technology
Country, which defends, requires emergency treatment report time to be accurate to point in planning commission tertiary hospitals evaluation detailed rules and regulations, Chinese doctors'associations patient Security target is to strengthen clinical critical value reporting system, and certification joint committee of International Medical health organ requires to establish effective Critical value reporting system.It can be that the quality time is won in medical act that critical value, which effectively finds and transmits, in medical image, reduce The death rate and disability rate.The screening of critical value relies on doctor's judgement in medical image at present, and the transmission of critical value is by artificial Phone and record.
The diagnoses and treatment as early as possible of critical disease can obviously reduce the death rate, improve prognosis.Pulmonary embolism, aorta clamp The critical disease such as layer, pressure pneumothorax can rapid contribution cardio-pulmonary function and lethality is high, dept. of radiology check in these three medicals diagnosis on disease In play a key effect.Pulmonary embolism is one of clinical common acute disease, and incidence may be up to 70/,100,000, nearly 25% it is acute Pulmonary embolism can die suddenly, and the pulmonary embolism death rate of untreated is up to 60%, if can be diagnosed in time and correct Treatment case fatality rate can drop to 2-8%.Dissection of aorta annual morbidity about 2.6-3.5/10 ten thousand, the death rate reaches in 24 hours 25%, the death rate is up to 50% in one week;Early diagnosis, which is intervened, can obviously reduce the death rate.The incidence of spontaneous pneumothorax is in 2.5- 18/100000, pneumothorax or pressure pneumothorax are formed in original underlying lung diseases such as pulmonary emphysema, general symptom is heavier, influences the heart Lung function is apparent, endangers larger, the death rate about 4.7%.These three critical sick diverse clinical manifestations, lack specificity, radiation It is the most important evidence diagnosed that section, which checks, and diagnosis as early as possible can be that treatment gain time.
Critical disease delays the diagnosis and treatment as physician-patient relationship tense major reason.The first sentence in 2013 of Beijing municipal court conclude 1044 In part case, emergency department accounts for 8.3%, occupies the 4th.China of Beijing material evidence evaluating center was from January, 2010 to 2014 10 Accept Medical Dispute Appraisal 500 moon altogether, orthopaedics case section office occurred frequently are the first, wherein because pulmonary artery occur in fracture or fracture surgery Embolism and death large percentage.It is counted in being summarized according to one of New England Journal of Medicine:Emergency department and essence in United States Hospital Refreshing ward is the place that occurs most frequently of violence wound doctor, and Nurses of Emergency Department is abused in the interviewed prior year 100%, 82.1% by Personal attack, about 1/4 emergency department doctor become the target of workplace violence in last year.Report delay has been the U.S. The main reason for dept. of radiology is by lawsuit, single case are judged to claimable amount up to 1,900,000 U.S. dollars.To the critical value in dept. of radiology's picture and text Detection will reduce medical-risk.
In order to protect patient safety and improve quality of medical care, the clinical procedure guide of domestic and international associated mechanisms, which has, clearly to be radiated The requirement of the critical value reporting system of section.Certification joint committee of International Medical health organ determines danger in patient safety target The report validity being suddenly worth.Certification joint committee of synthesis International Medical health organ of Univ Massachusetts Medical, the U.S. are put The specification for penetrating association, Massachusetts malpractice prevention alliance, has formulated the critical value reporting system of dept. of radiology, has been divided into three-level:(1) red Alarm, it is necessary to be reported in 1 hour, including airway obstruction, new pneumothorax, the unexpected free gas in abdominal cavity for occurring or being obviously in progress Pipeline position is supported in body, aneurysm rupture, artery dissection, acute spinal compressing, intestinal obstruction, pulmonary embolism, medical treatment detection Abnormal, ectopic pregnancy;(2) Amber Alert need to be reported in 8 hours, including doubtful child abuse, unexpected lump, new life Three degree of hydrocephalus of youngster, doubtful active tuberculosis;(3) warning yellow needs to report in 24 hours, including preoperative planning finds lung knot Section, single-shot kidney lump.European Society of Radiology proposes guide to the effective communication of the critical value of dept. of radiology, from Systematic and implementation Level gives feasible method;They emphasize that the clinical supervisor that is sent to that dept. of radiology has a responsibility for ensuring to report promptly and accurately cures It is raw.The tertiary hospitals of China's health and Family Planning Committee are evaluated detailed rules for the implementation (2011 editions) traditional Chinese medicine Image Management and are continued Improving in chapters and sections requires the timely specification of Medical imaging diagnostic reports, emergency treatment report time to be accurate to minute.Chinese Hospital Association Target six is to strengthen clinical critical value reporting system, specification inspection, image, electrocardiogram in patient safety target 2014-2015 editions In critical value effectively report.Each mechanism especially emphasizes the timeliness and validity of critical value report executing, but for radiation The method that University of Science and Technology's data deficiency science embodies, it is difficult to meet the state of an illness demand of individual.
Traditional natural language processing techniques use syntactic analysis and phrase structure rule.American-European countries researcher is to dept. of radiology The research that report carries out natural language processing is more, but there is not yet the correlative study that Chinese natural language is handled.The scholars such as Ewoud Summarize five big applications of the natural language processing in medical image report analysis:Diagnostic monitoring, epidemiological study queue are built Vertical, case return visit, quality control, clinical information support etc..Diagnostic result in report is monitored in real time, is conducive in time Clinical supervisor doctor is reminded to carry out clinical decision.Current diagnosis monitoring concentrates on monitoring appendicitis, acute lung injury, pneumonia, blood Bolt embolism class diseases, malignant tumour etc., which part monitor for critical value.Lakhani research teams using it is rule-based from Image report of the right language processing techniques to 9 kinds of critical illness such as pneumothorax, acute pulmonary embolism, acute appendicitis, ectopic pregnancy It accuses text to be detected, accuracy is in 81%-100%.And it carries out natural language processing using deep learning and is based on corpus Construction and statistical theory application, will further improve accuracy.Nearly 10 years with the continuous propulsion of medical information, radiation Section's data volume constantly increases, and providing data for the computer-aided diagnosis system based on deep learning supports.The accumulation of data, The support of hardware, the breakthrough of algorithm provide sufficient and necessary condition for critical value intelligent information excavation in dept. of radiology's picture and text.
Invention content
The purpose of the present invention is to provide a kind of critical value diagnosis and therapy systems of intelligence, are transmitted with solving the critical value of existing disease The busy problem of speed.
In order to solve the above technical problems, the present invention provides a kind of critical value diagnosis and therapy system of intelligence, the critical value of intelligence is examined Treatment system includes critical value screening module and critical value transfer module, wherein:
The critical value screening module establishes critical Value Data library, and the critical Value Data library is trained and is tested Card, obtains critical value-based algorithm;
Critical Value Data library is divided into critical value positive data library and the negative data of critical value by the critical value screening module Library, and critical value positive data library is randomly divided into positive training library and positive verification library by a certain percentage, by a certain percentage will The negative database of critical value is randomly divided into negative training library and negative verification library, is trained using positive training library and negative training library Critical value-based algorithm verifies critical value-based algorithm using positive verification library and negative verification library;
Check whether the data of radiology image and radiology report have critical illness by the critical value-based algorithm, if With critical illness, then and after being verified start warning device, and clinic is sent to by the critical value transfer module Doctor.
Optionally, in the critical value diagnosis and therapy system of intelligence, the critical value includes the critical value of pulmonary embolism, master The critical value of artery dissection and the critical value of pneumothorax.
Optionally, in the critical value diagnosis and therapy system of intelligence, the critical value screening module includes deep learning figure As identification module and natural language processing module, wherein:
The deep learning picture recognition module carries out the critical value information of image to radiology image and extracts, the nature language Say that processing module carries out the critical value information of word to radiology report and extracts;
The critical Value Data library is trained and is verified by the critical value information of image and the critical value information of word, is obtained To critical value-based algorithm.
Optionally, in the critical value diagnosis and therapy system of intelligence, before establishing critical Value Data library, the critical value sieve It looks into module and removes privacy information in radiology image and radiology report.
Optionally, in the critical value diagnosis and therapy system of intelligence, the critical value positive data library includes dynamic with lung The radiology image and radiology report of arteries and veins embolism, dissection of aorta and pneumothorax situation, the negative database of critical value include Radiology image and radiology report without pulmonary embolism, dissection of aorta and pneumothorax situation.
Optionally, in the critical value diagnosis and therapy system of intelligence, positive training library and negative training library training danger are utilized Before anxious value-based algorithm, the critical value-based algorithm is built using the positive training library and the negative training library.
Optionally, in the critical value diagnosis and therapy system of intelligence, the critical value screening module is by recycling nerve net Network and convolutional neural networks build the critical value-based algorithm.
Optionally, in the critical value diagnosis and therapy system of intelligence, the positive verification library and the negative verification are utilized Before the critical value-based algorithm is examined in library, the data that doctor verifies in the positive verification library and the negative verification library are correct 's.
Optionally, in the critical value diagnosis and therapy system of intelligence, the ratio is 9:1.
It optionally, can to the highest feature progress of the critical value-based algorithm in the critical value diagnosis and therapy system of intelligence It is handled depending on change, to carry out visualization processing to the critical value of the radiology image.
Optionally, in the critical value diagnosis and therapy system of intelligence, critical value positive data library and critical value the moon are being established Property database before, the data in critical Value Data library are manually marked, positive data and negative data are divided into, will be negative Data are put into the negative database of critical value, and the illness of positive data is further carried out automatic marking, and by manual verification come Confirm whether automatic marking is correct, and positive data is then put into critical value positive data library.
In the critical value diagnosis and therapy system of intelligence provided by the invention, critical value screening module generates in medical image and uploads clothes Screening is carried out to it at the first time after business device, finds suspicious critical value, responsibility dept. of radiology doctor is notified by Internet technology at once Teacher, radiologist notify responsibility clinician by development of Mobile Internet technology at once after confirming, realize the critical value of disease Quickly confirm and transmit, gains time for treatment.
In addition, the critical value-based algorithm excavated by establishing the critical value information of dept. of radiology's picture and text based on deep learning, real Now following effect:Pulmonary embolism, dissection of aorta, pneumothorax intelligent recognition accuracy rate 99.9% or so in radiology report, it is false Negative rate is less than 0.1%.For pulmonary embolism digital image recognition accuracy rate 93% or so, false negative rate is less than 3%.Aorta For interlayer digital image recognition accuracy rate 95% or so, false negative rate is less than 1%.Pneumothorax intelligent recognition accuracy rate is on 98% left side The right side, false negative rate are less than 1%.
Description of the drawings
Fig. 1 is one embodiment of the invention intelligently critical value diagnosis and therapy system schematic diagram.
Specific implementation mode
Make below in conjunction with the drawings and specific embodiments value diagnosis and therapy system critical to intelligence proposed by the present invention further detailed Explanation.According to following explanation and claims, advantages and features of the invention will become apparent from.It should be noted that attached drawing is adopted Use with very simplified form and non-accurate ratio, only to it is convenient, lucidly aid in illustrating the embodiment of the present invention Purpose.
Core of the invention thought is to provide a kind of critical value diagnosis and therapy system of intelligence, to solve the critical value of existing disease The busy problem of transmission speed.
To realize above-mentioned thought, the present invention provides a kind of critical value diagnosis and therapy system of intelligence, the critical value screening module Critical Value Data library is established, and the critical Value Data library is trained and is verified, obtains critical value-based algorithm;The critical value Critical Value Data library is divided into critical value positive data library and the negative database of critical value by screening module, and by a certain percentage will danger Anxious value positive data library is randomly divided into positive training library and positive verification library, by a certain percentage that the negative database of critical value is random It is divided into negative training library and negative verification library, trains critical value-based algorithm using positive training library and negative training library, utilize the positive Verification library and negative verification library verify critical value-based algorithm;Radiology image and radiology report are checked by the critical value-based algorithm Data whether there is critical illness, if having critical illness, and start warning device after being verified, and described in Critical value transfer module is sent to clinician.
The present embodiment provides a kind of critical value diagnosis and therapy systems of intelligence, as shown in Figure 1, the critical value diagnosis and therapy system packet of the intelligence Critical value screening module and critical value transfer module are included, wherein:The critical value screening module establishes critical Value Data library, and right The critical Value Data library is trained and verifies, and obtains critical value-based algorithm;The critical value screening module is by critical Value Data Library is divided into critical value positive data library and the negative database of critical value, and (ratio is 9 by a certain percentage:1) by critical value Positive data library is randomly divided into positive training library and positive verification library, and (ratio is 9 by a certain percentage:1) by critical value the moon Property database be randomly divided into negative training library and negative verification library, train critical value calculation using positive training library and negative training library Method verifies critical value-based algorithm using positive verification library and negative verification library;Radiology image is checked by the critical value-based algorithm Whether there is critical illness with the data of radiology report, if having critical illness, and starts alarm dress after being verified It sets, and clinician is sent to by the critical value transfer module.
The critical value diagnosis and therapy system of the intelligence can also include a critical value setup module, the critical value setup module For being arranged to identify the keyword of the critical value of medicine, it is high that the critical value of medicine refers to a certain or certain class medical inspection result Degree is abnormal, and patient may be in the rim condition being in peril of one's life, for example, the critical value include the critical value of pulmonary embolism, The critical value of dissection of aorta and the critical value of pneumothorax.Alternatively, when the critical value diagnosis and therapy system of intelligence is used for different department, different department The corresponding different keyword.
Specifically, in the critical value diagnosis and therapy system of intelligence, the critical value screening module includes deep learning figure As identification module and natural language processing module, wherein:The deep learning picture recognition module carries out figure to radiology image As the extraction of critical value information, the natural language processing module carries out the critical value information of word to radiology report and extracts, to report The keyword occurred in announcement is identified, and recognition result is extracted;Pass through the critical value information of image and the critical value of word Information is trained and verifies to the critical Value Data library, obtains critical value-based algorithm.
In addition to the privacy of protection patient is establishing critical Value Data in the critical value diagnosis and therapy system of intelligence Before library, the critical value screening module removes the privacy information in radiology image and radiology report, such as patient's name, trouble Person's gender, patient age, application section office etc..
Further, in the critical value diagnosis and therapy system of intelligence, the critical value positive data library includes having lung The radiology image and radiology report of arterial embolism, dissection of aorta and pneumothorax situation, the negative database packet of critical value Include radiology image and radiology report without pulmonary embolism, dissection of aorta and pneumothorax situation.Utilize positive training Before critical value-based algorithm is trained in library and negative training library, built using the positive training library and the negative training library described critical Value-based algorithm.The critical value screening module builds the critical value-based algorithm by Recognition with Recurrent Neural Network and convolutional neural networks.Profit Before examining the critical value-based algorithm with the positive verification library and the negative verification library, doctor verify the positive verification library and Data in the feminine gender verification library are correct.
In addition, in the critical value diagnosis and therapy system of intelligence, the highest feature of the critical value-based algorithm is carried out visual Change is handled, to carry out visualization processing to the critical value of the radiology image.Establishing critical value positive data library and critical Before the negative database of value, the data in critical Value Data library are manually marked, are divided into positive data and negative data, it will Negative data are put into the negative database of critical value, the illness of positive data are further carried out automatic marking, and by manually testing It demonstrate,proves to confirm whether automatic marking is correct, positive data is then put into critical value positive data library.
In the critical value diagnosis and therapy system of intelligence provided by the invention, critical value screening module generates in medical image and uploads clothes Screening is carried out to it at the first time after business device, finds suspicious critical value, responsibility dept. of radiology doctor is notified by Internet technology at once Teacher, radiologist notify responsibility clinician by development of Mobile Internet technology at once after confirming, realize the critical value of disease Quickly confirm and transmit, gains time for treatment.
In addition, the critical value-based algorithm excavated by establishing the critical value information of dept. of radiology's picture and text based on deep learning, real Now following effect:Pulmonary embolism, dissection of aorta, pneumothorax intelligent recognition accuracy rate 99.9% or so in radiology report, it is false Negative rate is less than 0.1%.For pulmonary embolism digital image recognition accuracy rate 93% or so, false negative rate is less than 3%.Aorta For interlayer digital image recognition accuracy rate 95% or so, false negative rate is less than 1%.Pneumothorax intelligent recognition accuracy rate is on 98% left side The right side, false negative rate are less than 1%.
As shown in Figure 1, for the critical value diagnosis and therapy system of intelligence, some radiology images and report are obtained first, and Privacy information is removed, these images and report are put into newly-established critical Value Data library, doctor is by manual sort, by image It is divided into positive data and negative data with report, negative data is directly put into negative database, to positive data into advancing one The mark of step marks its specific illness, and is then marked automatically by manual verification again with critical value-based algorithm automatic marking again Whether note is accurate, to optimize critical value-based algorithm, optimizes illness mark completion of the verification up to all positive data repeatedly with this, will It is put into positive data library.The data in positive data library are divided into 10 equal portions, a data composition positive verification library, nine parts of data The data of negative database are divided into 10 equal portions, a negative verification library of data composition, nine parts of data groups by the positive training library of composition At feminine gender training library.The data in positive training library and negative training library are merged, are trained using the data in two trained libraries critical Value-based algorithm makes critical value-based algorithm carry out deep learning, until its own can judge critical value illness, at this time by positive verification library and The data of negative verification library merge, and whether the data mark of the artificial nuclear tests card database of doctor is correct, if correctly, it will verification Library data issue critical value-based algorithm, and make critical value-based algorithm that verification library data are carried out with the diagnosis of critical value illness, to judge to calculate Whether method reaches requirement, is advanced optimized if it cannot reach requirement, furthermore with visualization technique, by examining for critical value illness It is disconnected to carry out visualization processing, keep diagnostic result more very clear.
To sum up, the various configuration of the critical value diagnosis and therapy system of intelligence is described in detail in above-described embodiment, certainly, this hair Cited configuration in bright including but not limited to above-mentioned implementation, it is any to be become on the basis of the configuration of above-described embodiment offer The content changed belongs to the range that the present invention is protected.Those skilled in the art can lift one according to the content of above-described embodiment Anti- three.
Foregoing description is only the description to present pre-ferred embodiments, not to any restriction of the scope of the invention, this hair Any change, the modification that the those of ordinary skill in bright field does according to the disclosure above content, belong to the protection of claims Range.

Claims (11)

1. a kind of critical value diagnosis and therapy system of intelligence, which is characterized in that the critical value diagnosis and therapy system of intelligence includes critical value screening Module and critical value transfer module, wherein:
The critical value screening module establishes critical Value Data library, and the critical Value Data library is trained and is verified, and obtains To critical value-based algorithm;
Critical Value Data library is divided into critical value positive data library and the negative database of critical value by the critical value screening module, and Critical value positive data library is randomly divided into positive training library and positive verification library by a certain percentage, by a certain percentage by critical value Negative database is randomly divided into negative training library and negative verification library, and critical value is trained using positive training library and negative training library Algorithm verifies critical value-based algorithm using positive verification library and negative verification library;
Check whether the data of radiology image and radiology report have critical illness by the critical value-based algorithm, if having Critical illness then and after being verified starts warning device, and is sent to clinician by the critical value transfer module.
2. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that the critical value includes pulmonary embolism The critical value of critical value, dissection of aorta and the critical value of pneumothorax.
3. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that the critical value screening module includes deep Degree study picture recognition module and natural language processing module, wherein:
The deep learning picture recognition module carries out the critical value information of image to radiology image and extracts, at the natural language It manages module and the critical value information extraction of word is carried out to radiology report;
The critical Value Data library is trained and is verified by the critical value information of image and the critical value information of word, is endangered Anxious value-based algorithm.
4. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that before establishing critical Value Data library, institute It states critical value screening module and removes privacy information in radiology image and radiology report.
5. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that the critical value positive data library includes Radiology image and radiology report with pulmonary embolism, dissection of aorta and pneumothorax situation, the negative number of critical value Include radiology image and radiology report without pulmonary embolism, dissection of aorta and pneumothorax situation according to library.
6. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that trained using positive training library and feminine gender Before critical value-based algorithm is trained in library, the critical value-based algorithm is built using the positive training library and the negative training library.
7. the critical value diagnosis and therapy system of intelligence as claimed in claim 6, which is characterized in that the critical value screening module is by following Ring neural network and convolutional neural networks build the critical value-based algorithm.
8. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that utilize the positive verification library and described Before negative verification library examines the critical value-based algorithm, doctor verifies the data in the positive verification library and the negative verification library It is correct.
9. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that the ratio is 9:1.
10. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that the highest of the critical value-based algorithm Feature carries out visualization processing, to carry out visualization processing to the critical value of the radiology image.
11. the critical value diagnosis and therapy system of intelligence as described in claim 1, which is characterized in that establishing critical value positive data library Before the negative database of critical value, the data in critical Value Data library are manually marked, positive data and feminine gender are divided into Negative data are put into the negative database of critical value, the illness of positive data are further carried out automatic marking, and pass through by data Manual verification confirms whether automatic marking is correct, then positive data is put into critical value positive data library.
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