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CN108478731A - Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease - Google Patents

Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease Download PDF

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Publication number
CN108478731A
CN108478731A CN201810661787.4A CN201810661787A CN108478731A CN 108478731 A CN108478731 A CN 108478731A CN 201810661787 A CN201810661787 A CN 201810661787A CN 108478731 A CN108478731 A CN 108478731A
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Prior art keywords
parts
radix
chinese medicine
heart disease
coronary heart
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CN201810661787.4A
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Chinese (zh)
Inventor
石国剑
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Jiangsu Hundred Sword Pharmaceutical Technology Co Ltd
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Jiangsu Hundred Sword Pharmaceutical Technology Co Ltd
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Priority to CN201810661787.4A priority Critical patent/CN108478731A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/233Bupleurum
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract

The present invention relates to a kind of Chinese medicine preparations for treating cardiovascular stasis coronary heart disease, it is made of Radix Salviae Miltiorrhizae, ginkgo leaf, corydalis tuber, Rhizoma Chuanxiong, malt, moutan bark, hawthorn, ginseng, peach kernel, safflower, radix paeoniae rubra, Caulis Spatholobi, Fructus Aurantii, dried orange peel, Artemisia anomala, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Rehmanniae, radix bupleuri, dalbergia wood, Radix Paeoniae Alba, Longstamen Onion Bulb, campanulaceae, the stem pith of the rice-paper plant, excrementum pteropi, cassia twig, radix polygonati officinalis, Radix Notoginseng, storax and borneol according to the mass fraction.Has the effects that promoting blood circulation and removing blood stasis, coronary circulation-promoting pain-relieving, cure rate is 90% or more.Meanwhile the hypertension that can induce cardiovascular stasis coronary heart disease, hyperlipidemia can be alleviated or be cured to the Chinese medicine preparation.

Description

Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease
Technical field
The present invention relates to the Chinese patent drugs for the treatment of coronary heart disease, and the Chinese medicine for more particularly, to treating cardiovascular stasis coronary heart disease is matched Side.In addition the invention further relates to using Chinese medicinal capsule, Chinese medicinal pill made of the Chinese medicine preparation.It finds particular application to painstaking effort Blood stasis blocking type coronary disease and angina pectoris also has certain curative effect for myocardial infarction and heart failure etc..
Background technology
Although coronary heart disease is all coronary artery pathological changes, according to the difference of clinical manifestation, angina pectoris, cardiac muscle can be divided into Infarct, heart failure and arrhythmia cordis etc., wherein angina pectoris is most commonly seen.Before middle medical drugs treatment coronary heart disease, first to divide Type is dialectical, and difference is dialectical to be needed to combine using different pharmaceutical.The stagnation of the heart blood is a kind of common type of coronary disease and angina pectoris.It is existing Patent document disclose it is multiple treatment cardiovascular stasis coronary heart diseases (angina pectoris) Chinese patent drugs.
96115634.1 being related to a kind of traditional Chinese medicine oral liquid for treating coronary heart diseases and angina pectoris.The case shows, Radix Salviae Miltiorrhizae and moutan bark Be conducive to the obstruction of qi in the chest caused by treating the stagnation of the heart blood.
99102847.3 are related to a kind of rhodiola rosea injection for treating coronary disease and angina pectoris, which extracts from rhodiola root and control The active ingredient of coronary disease and angina pectoris is treated, which there are obvious curative effects to coronary disease and angina pectoris caused by the stagnation of the heart blood.
02146248.8 (1186069C) is related to a kind of with promoting blood circulation and removing blood stasis, the Chinese medicine preparation of regulating qi-flowing for relieving pain effect, at this In case, radix bupleuri can soothing liver-qi stagnation, Fructus Aurantii can promoting the circulation of qi go it is stagnant.
200610173375.3 (100546639C) disclose a kind of Chinese herbal medicine pill for treating coronary heart disease, which illustrates Effect of the borneol in treating heart blood silt.
200710133059.8 treatment palpitation and uneasiness, the Chinese medicine of shortness of breath uncomfortable in chest discloses Radix Rehmanniae, Radix Curcumae and peach kernel has Conducive to the alleviation stagnation of the heart blood.
200910023341.X or 200910023338.8 disclose treatment coronary heart diseases and angina pectoris medicine pill, text Offering the middle a small amount of borneol of display can have effect.
200910064559.X is related to a kind of thrombolysis decoction for treating angiocardiopathy, in the case, ginseng, Snakegourd Fruit and Radix Curcumae Effect in treating type of obstruction of heart-blood angiocardiopathy can be included in term of reference.
200910086871.9 treatment coronary disease and angina pectoris Chinese medicine preparation scheme it is simple, do not repeat.
201110273370.9 (102302550B) discloses the drug for the treatment of coronary heart disease comprising:Ginkgo leaf 20-30 Part, 15-25 parts of Radix Salviae Miltiorrhizae, 10-15 parts of Rhizoma Chuanxiong, 10-15 parts of safflower, 10-15 parts of pseudo-ginseng.This application is using ginkgo leaf as monarch drug in a prescription.
201110267629.9 (102302741B) disclose a kind of Chinese medicinal preparation method for treating the type of obstruction of heart-blood obstruction of qi in the chest, The component of the Chinese medicine is more, wherein the effect in treating the stagnation of the heart blood such as Artemisia anomala, Caulis Spatholobi, Longstamen Onion Bulb and rhizoma cyperi can be with The prior art as the application.In addition it is also possible to the Chinese medicine of the treatment type of obstruction of heart-blood palpitaition referring to 201110267624.6 Preparation method.
201210200040.1 are related to treating the safflower traditional Chinese herbal decoction of palpitaition and preparation method comprising safflower 100-140 Part, 200-280 parts of Radix Salviae Miltiorrhizae, 150-210 parts of ganoderma lucidum, 150-210 parts of radix paeoniae rubra, 100-140 parts of Rhizoma Chuanxiong, 150-210 parts of corydalis tuber.The heart Blood stasis resistance type palpitaition belongs to a kind of performance of angiocardiopathy, can be as reference.In addition, the 201110278139.9 treatment heart Blood stasis hinders the Chinese medicine preparation for causing palpitaition, also similar with this application.
In addition to above patent document, the drugs such as yufeng ningxin tablets, yufeng ningxin pian, ginkgo-leaf oral liquor and perhexiline injection are certain Coronary disease and angina pectoris caused by the stagnation of the heart blood can be treated in degree, but similar to existing patented technology, cure rate and curative effect Have much room for improvement.
Invention content
To solve problem of the prior art, the present invention provides a kind of treat in coronary disease and angina pectoris caused by the stagnation of the heart blood Medicine composition.The Chinese medicine preparation is according to the anginal feature of cardiovascular stasis coronary heart disease, reasonable compatibility ginkgo leaf, ginseng and excrementum pteropi Etc. components, reach and without adverse affects treat coronary disease and angina pectoris.
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease, which is characterized in that according to the mass fraction, by following At being grouped as:200~210 parts of Radix Salviae Miltiorrhizae, 180~210 parts of ginkgo leaf, 135~145 parts of corydalis tuber, 135~145 parts of Rhizoma Chuanxiong, malt 120~129 parts, 120~129 parts of moutan bark, 120~129 parts of hawthorn, 105~110 parts of ginseng, 105~110 parts of peach kernel, safranine Spend 105~110 parts, 105~110 parts of radix paeoniae rubra, 105~110 parts of Caulis Spatholobi, 90~110 parts of Fructus Aurantii, 86~110 parts of dried orange peel, Liu posts 86~89 parts of slave, 86~89 parts of Radix Glycyrrhizae, 86~89 parts of Radix Angelicae Sinensis, 86~89 parts of Radix Rehmanniae, 86~89 parts of radix bupleuri, 80~110 parts of dalbergia wood, 80~90 parts of Radix Paeoniae Alba, 80~85 parts of Longstamen Onion Bulb, 80~85 parts of campanulaceae, 55~70 parts of the stem pith of the rice-paper plant, 58~60 parts of excrementum pteropi, cassia twig 55~60 Part, 55~60 parts of radix polygonati officinalis, 55~60 parts of Radix Notoginseng, 40~50 parts of storax, 8~10 parts of borneol.
As preferred:210 parts of Radix Salviae Miltiorrhizae, 180 parts of ginkgo leaf, 145 parts of corydalis tuber, 145 parts of Rhizoma Chuanxiong, 129 parts of malt, moutan bark 129 parts, 129 parts of hawthorn, 110 parts of ginseng, 110 parts of peach kernel, 110 parts of safflower, 110 parts of radix paeoniae rubra, 110 parts of Caulis Spatholobi, Fructus Aurantii 90 Part, 86 parts of dried orange peel, 86 parts of Artemisia anomala, 86 parts of Radix Glycyrrhizae, 86 parts of Radix Angelicae Sinensis, 86 parts of Radix Rehmanniae, 86 parts of radix bupleuri, 80 parts of dalbergia wood, 80 parts of Radix Paeoniae Alba, 80 parts of Longstamen Onion Bulb, 80 parts of campanulaceae, 70 parts of the stem pith of the rice-paper plant, 60 parts of excrementum pteropi, 60 parts of cassia twig, 60 parts of radix polygonati officinalis, 60 parts of Radix Notoginseng, 50 parts of storax, 8 parts of borneol.
As preferred:200 parts of Radix Salviae Miltiorrhizae, 210 parts of ginkgo leaf, 135 parts of corydalis tuber, 145 parts of Rhizoma Chuanxiong, 120 parts of malt, moutan bark 120 parts, 120 parts of hawthorn, 105 parts of ginseng, 105 parts of peach kernel, 105 parts of safflower, 105 parts of radix paeoniae rubra, Caulis Spatholobi 105, Fructus Aurantii 110 Part, 110 parts of dried orange peel, 89 parts of Artemisia anomala, 89 parts of Radix Glycyrrhizae, 89 parts of Radix Angelicae Sinensis, 89 parts of Radix Rehmanniae, 89 parts of radix bupleuri, 110 parts of dalbergia wood, Radix Paeoniae Alba 90 Part, 85 parts of Longstamen Onion Bulb, 85 parts of campanulaceae, 55 parts of the stem pith of the rice-paper plant, 58 parts of excrementum pteropi, 55 parts of cassia twig, 55 parts of radix polygonati officinalis, 55 parts of Radix Notoginseng, storax 40 Part, 10 parts of borneol.
As preferred:205 parts of Radix Salviae Miltiorrhizae, 200 parts of ginkgo leaf, 140 parts of corydalis tuber, 138 parts of Rhizoma Chuanxiong, 125 parts of malt, moutan bark 125 parts, 125 parts of hawthorn, 100 parts of ginseng, 100 parts of peach kernel, 100 parts of safflower, 100 parts of radix paeoniae rubra, 100 parts of Caulis Spatholobi, Fructus Aurantii 100 Part, 100 parts of dried orange peel, 88 parts of Artemisia anomala, 86 parts of Radix Glycyrrhizae, 86 parts of Radix Angelicae Sinensis, 88 parts of Radix Rehmanniae, 86 parts of radix bupleuri, 90 parts of dalbergia wood, Radix Paeoniae Alba 85 Part, 82 parts of Longstamen Onion Bulb, 82 parts of campanulaceae, 65 parts of the stem pith of the rice-paper plant, 59 parts of excrementum pteropi, 58 parts of cassia twig, 58 parts of radix polygonati officinalis, 58 parts of Radix Notoginseng, storax 45 Part, 9 parts of borneol.
As preferred:200 parts of Radix Salviae Miltiorrhizae, 200 parts of ginkgo leaf, 140 parts of corydalis tuber, 140 parts of Rhizoma Chuanxiong, 125 parts of malt, moutan bark 125 parts, 125 parts of hawthorn, 100 parts of ginseng, 100 parts of peach kernel, 100 parts of safflower, 100 parts of radix paeoniae rubra, 100 parts of Caulis Spatholobi, Fructus Aurantii 100 Part, 100 parts of dried orange peel, 90 parts of Artemisia anomala, 90 parts of Radix Glycyrrhizae, 90 parts of Radix Angelicae Sinensis, 90 parts of Radix Rehmanniae, 90 parts of radix bupleuri, 100 parts of dalbergia wood, Radix Paeoniae Alba 80 Part, 80 parts of Longstamen Onion Bulb, 80 parts of campanulaceae, 60 parts of the stem pith of the rice-paper plant, 60 parts of excrementum pteropi, 60 parts of cassia twig, 60 parts of radix polygonati officinalis, 60 parts of Radix Notoginseng, storax 40 Part, 10 parts of borneol.
A kind of Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease, which is characterized in that including the Chinese medicine preparation.
It is a kind of for treating the Chinese medicinal pill of cardiovascular stasis coronary heart disease, which is characterized in that including the Chinese medicine preparation and Honey, mass ratio 1:0.5~1.5.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.
In the Chinese medicine preparation, the solvent is rice wine, and by mass percentage, the proportioning with Chinese medicine preparation is 1:8 ~10.
In the Chinese medicine preparation, the solvent is yellow rice wine, and by mass percentage, the proportioning with Chinese medicine preparation is 1:5 ~10.
In the Chinese medicine preparation, the solvent is ethyl alcohol, and by mass percentage, the proportioning with Chinese medicine preparation is 1:1 ~6.
The Chinese medicine preparation of this treatment cardiovascular stasis coronary heart disease of the present invention has the works such as promoting blood circulation and removing blood stasis, coronary circulation-promoting pain-relieving With curing mainly the stagnation of the heart blood, cure rate is 90% or more.The Chinese medicine preparation optimizes on the basis of considering each constituent content The proportioning of ginseng and excrementum pteropi improves effect promoting blood circulation and removing blood stasis.Although the Chinese medicine preparation is formed by several kinds of Chinese medicinal materials compatibility, It, which is cured mainly, defines, and has no toxic side effect.Meanwhile the height that can induce cardiovascular stasis coronary heart disease can be alleviated or be cured to the Chinese medicine preparation Blood pressure, hyperlipidemia.
Specific implementation mode
For the apparent present invention that illustrates, some that the prior art provides are summarized first and treat anginal scheme.The back of the body Scape technology segment has explained, and is no longer described in detail.Patent, patent application and other documents that the application directly quotes, are included in As reference, other do not make the part expressed, with reference to known technology for this case.
Existing patent document discloses multiple documents for treating coronary heart disease.
201110048251.3 (102119971B) are related to a kind of Chinese medicine for treating coronary heart disease comprising 1-3 parts of peach branch turns over 0.5-1 parts of white 1-3 parts of grass, 0.5-1 parts of Moschus, 2-5 parts of Pemisetum flaccidum Griseb, 1-3 parts of Asiatic plantain and illiciumverum.Coronary heart disease differentiation of symptoms and signs for classification of syndrome is multiple Miscellaneous, same component is not easy to treat all types of coronary heart disease.
201310342311.1 are related to a kind of drug for treating coronary heart diseases and angina pectoris, the white 20-60g of safflower 20-60g, a round bamboo basket, Campanulaceae 10-30g, grass-leaved sweetflag 5-15g, cassia twig 10-30g, corydalis tuber 10-20g, Snakegourd Fruit 30-100g, potentilla discolor 10-30g, Moschus 10-30g, root of Aucklandia lappa Decne 10-30g, seed of Oriental arborvitae 20-60g, Caulis Spatholobi 10-30g, Radix Ophiopogonis 10-30g, Asiatic plantain 20-60g, pueraria lobata 10- 30g, thizoma curculiginis 10-20g, excrementum pteropi 10-30g, peach kernel 10-20g, Radix Polygalae 20-60g, lepidium seed 10-30g, big gun first 5-15g, melia toosendan Sub- 5-15g, rhizoma zingiberis 5-15g, toast grass 10-30g.
201210541518.7 being related to a kind of Chinese medicine preparation for coronary disease and angina pectoris, by the Chinese medicine of following weight proportion Formula material medicine is prepared:220-260 parts of corydalis tuber, 4-12 parts of Moschus, 4-12 parts of storax, 100-140 parts of Rhizoma Chuanxiong, ginseng 100-140 parts, 6-18 parts of borneol.The borneol thoughts of returning home, liver can control blood stasis.Borneol is toxic, should limit its intake.
201110453345.9 disclose a kind of Chinese medicine preparation for treating coronary disease and angina pectoris, by Radix Codonopsis, Radix Astragali, mulberry Shen, Rhizoma Chuanxiong, Radix Curcumae, excrementum pteropi, rose, semen litchi and agalloch eaglewood.Radix Codonopsis, Radix Astragali, mulberries, Rhizoma Chuanxiong, Radix Curcumae, excrementum pteropi are equal To treat the good medicine of qi stagnation and blood stasis type coronary heart disease.
201110174824.7 are related to a kind of drug for treating coronary heart disease, optimize American ginseng total saponins and corydalis tuber second The proportioning of element.
201110155727.3 are related to treating the Chinese medicine of coronary heart disease comprising 25~50 parts of radix rehmanniae preparata, 10~25 parts of Fructus Corni, 15~30 parts of Herba Cistanches, 5~20 parts of gun additioner, 5~15 parts of ginseng, 15~25 parts of Radix Ophiopogonis, 2.5~10 parts of Schisandra chinensis, cassia twig 5~ 15 parts, 5~10 parts of Radix Glycyrrhizae, 10~25 parts of Radix Angelicae Sinensis, 15~50 parts of Radix Astragali, 15~50 parts of Radix Salviae Miltiorrhizae, 1.5~5 parts of santal, fructus amomi 5~ 10 parts, 5~15 parts of Rhizoma Chuanxiong, 10~20 parts of hawthorn, 15~25 parts of honeysuckle flower, 15~25 parts of radix scrophulariae, 15~50 parts of Radix Rehmanniae.The case is with same One component treats all types of coronary heart disease.
Although ancient Chinese medicine has the saying of " ginseng fear excrementum pteropi ", modern TCM is studies have shown that reasonably matching Or under rational solvent action, people, which participates in excrementum pteropi compatibility, can treat a variety of diseases.For example,《Ginseng, excrementum pteropi compatibility pair The experimental study of A549 human lung adenocarcinoma cell lines effect》(Traditional Chinese Medicinal College of Liaoning Wang Jin),《Ginseng fears the chemical substance of excrementum pteropi Basic research》(when treasure's traditional Chinese medical science traditional Chinese medicines howl ring D etc.),《Ginseng is simply analysed with excrementum pteropi " mutual restraint between two drugs "》Liu Yuchun etc.,《Ginseng, five spirits The modern study of fat compatibility is in progress》(Chinese traditional Chinese medicine magazine Li Lian Jun etc.) has all made this careful research.Certainly, ginseng Influence of other compositions in prescription, such as Radix Salviae Miltiorrhizae, Radix Astragali etc. are had to take into account that with the proportion compatibility of excrementum pteropi.Existing patent text Offer the patent formula for also disclosing that some ginseng compatibility's excrementum pteropis.In view of other components in prescription, in this application, ginseng: Excrementum pteropi is 120~125:74~76.
01131203.3 (1124153B) discloses a kind of medicinal composition for restoring cardiac collaterals, for treating coronary disease and angina pectoris. It includes the clinically ginseng of Rational Dosage, Radix Codonopsis, radix pseudostellariae, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Chinese yam one of which or several;Water Leech, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, safflower, radix paeoniae rubra, dalbergia wood, Radix Notoginseng, Radix Curcumae, peach kernel, corydalis tuber, ground bettle, frankincense, dragon's blood, myrrh, chicken blood Rattan, agalloch eaglewood, curcuma zedoary, trigone, motherwort, excrementum pteropi, the root of bidentate achyranthes, melon wither, the tuber of pinellia, longstamen onion bulb and the almonds, Fructus Aurantii, the dried immature fruit of citron orange, santal, rhizoma cyperi, It is root of Aucklandia lappa Decne, dried orange peel, campanulaceae, corydalis tuber, the fleece-flower root, Radix Angelicae Sinensis, prepared rehmannia root, Radix Paeoniae Alba, Radix Ophiopogonis, sealwort, borneol, grass-leaved sweetflag, spina date seed, remote Will, amber, asarum, monkshood, cassia twig, Herba Epimedii, Schisandra chinensis, hawthorn, pueraria lobata, Poria cocos, the root of Dahurain angelica, radix bupleuri, earthworm, Rhizoma Gastrodiae wherein one Kind or several and scorpio, cicada slough, centipede one of which or several combination preparations.The specific embodiment of the case is more, each group Point play the role of promoting blood circulation and removing blood stasis, but is whether to be used equally for treatment coronary disease and angina pectoris, needs positive research.
200810127216.9 are related to a kind of medicinal liquor for treating coronary heart disease comprising Radix Salviae Miltiorrhizae, corydalis tuber, hawthorn, ginseng, meat Osmanthus, Radix Angelicae Sinensis, cordyceps sinensis, safflower, Rhizoma Chuanxiong, tangerine pith, lanatechead saussurea herb with flower, Radix Notoginseng, excrementum pteropi and glutinous rice wine.In the case, people participates in five Clever fat equivalent.
200810127966.6 disclose a kind of method for the treatment of swine coronary diseases with traditional Chinese medicines, Radix Salviae Miltiorrhizae, corydalis tuber, hawthorn, ginseng, Chinese cassia tree, Radix Angelicae Sinensis, cordyceps sinensis, safflower, Rhizoma Chuanxiong, tangerine pith, lanatechead saussurea herb with flower, Radix Notoginseng, excrementum pteropi.In the case, ginseng is less than excrementum pteropi.According to Claim, which can be used for treating swine coronary diseases.
200910234765.0 are related to a kind of Chinese medicine for treating swine coronary diseases, by 40 grams of cassia seed, 50 grams of Radix Salviae Miltiorrhizae, rhizoma anemarrhenae 20 Gram, 30 grams of hawthorn, 10 grams of ginseng, 20 grams of radix paeoniae rubra, 20 grams of Radix Angelicae Sinensis, 20 grams of cordyceps sinensis, 20 grams of safflower, 20 grams of Rhizoma Chuanxiong, peach kernel 20 Gram, 20 grams of lanatechead saussurea herb with flower, 40 grams of motherwort, 50 grams of Radix Notoginseng, 20 grams of excrementum pteropi composition.In the case, the quantity of ginseng is less than excrementum pteropi.
200910019636.X is related to a kind of Chinese medicine preparation and preparation method thereof for treating palace blood comprising ginseng, Radix Astragali, Cortex Phellodendri, tortoiseshell, scutellaria, the fruit of Cherokee rose, Radix Paeoniae Alba, RADIX POLYGONI MULTIFLORI PREPARATA, moxibustion Radix Glycyrrhizae, Radix Angelicae Sinensis, rhizoma cyperi, gun ginger, radix rehmanniae preparata, Chinese mugwort charcoal, Rhizoma Atractylodis Macrocephalae and Cyrtomium rhizome charcoal.Ginseng, Radix Astragali, Radix Glycyrrhizae and Radix Angelicae Sinensis etc. are the good medicine for treating qi depression to blood stasis.
201010263713.9 disclose a kind of drug and preparation method thereof for treating coronary heart disease, and people participates in five spirits in the case The proportioning of fat is 1~20:1~20.Excrementum pteropi contains the ingredient for reducing ginseng effect, and people participates in excrementum pteropi and matches in big ratio range 5, it may be decreased effect or generate side effect.
201210537333.9 a kind of Chinese medicine preparation for treating menorrhalgia is made of each raw material of following parts by weight:Ginseng 20~40 parts, 20~40 parts of Radix Astragali, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 3~9 parts of honey-fried licorice root, 3~9 parts of cimicifugae foetidae, 5~15 parts of donkey-hide gelatin, Radix Rehmanniae 10 ~20 parts, 8~15 parts of cattail pollen, 10~30 parts of motherwort, 5~15 parts of excrementum pteropi, 3~9 parts of Radix Notoginseng, 3~9 parts of madder.The Chinese medicine In component, ginseng is about two to four times of excrementum pteropi.
201010288583.4 a kind of Chinese medicine preparation for treating caput femoris necrosis is disclosed, including:Prepared fleece flower root 10-20 Part, 10-20 parts of prepared rehmannia root, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of donkey-hide gelatin, 10-20 parts of Radix Paeoniae Alba, 5-10 parts of ginseng, 10-20 parts of Radix Codonopsis, 10-20 parts of radix pseudostellariae, 10-20 parts of Radix Astragali, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Chinese yam, 10-15 parts of frankincense, 10-15 parts of myrrh prolong 10-15 parts of Hu rope, 10-15 parts of excrementum pteropi.The case treats caput femoris necrosis in a manner of promoting blood circulation and removing blood stasis, nourishing liver and kidney.
201310468625.6, which disclose a kind of ginseng, activates blood circulation and disperses blood clots the formula of wine, including 20-35 parts of ginseng, corydalis tuber 10-30 parts, 10-30 parts of blood clam, 10-30 parts of madder, 10-30 parts of kelp, 10-30 parts of radish seed, art 10-30 parts wide, Exocarpium Citri Rubrum 10-30 parts, 10-30 parts of excrementum pteropi, 10-30 parts of Herba Lycopi, 10-30 parts of trigone, 10-30 parts of bush, 10-30 parts of leech, root of bidentate achyranthes 10- 30 parts, 10-30 parts of turmeric, 10-30 parts of ivy, 10-30 parts of China rose.The content of ginseng is slightly larger than excrementum pteropi in the case.
The present invention's is this for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, according to the mass fraction, by below at It is grouped as:200~210 parts of Radix Salviae Miltiorrhizae, 180~210 parts of ginkgo leaf, 135~145 parts of corydalis tuber, 135~145 parts of Rhizoma Chuanxiong, malt 120~129 parts, 120~129 parts of moutan bark, 120~129 parts of hawthorn, 105~110 parts of ginseng, 105~110 parts of peach kernel, safranine Spend 105~110 parts, 105~110 parts of radix paeoniae rubra, 105~110 parts of Caulis Spatholobi, 90~110 parts of Fructus Aurantii, 86~110 parts of dried orange peel, Liu posts 86~89 parts of slave, 86~89 parts of Radix Glycyrrhizae, 86~89 parts of Radix Angelicae Sinensis, 86~89 parts of Radix Rehmanniae, 86~89 parts of radix bupleuri, 80~110 parts of dalbergia wood, 80~90 parts of Radix Paeoniae Alba, 80~85 parts of Longstamen Onion Bulb, 80~85 parts of campanulaceae, 55~70 parts of the stem pith of the rice-paper plant, 58~60 parts of excrementum pteropi, cassia twig 55~60 Part, 55~60 parts of radix polygonati officinalis, 55~60 parts of Radix Notoginseng, 40~50 parts of storax, 8~10 parts of borneol.
Pharmacology:Radix Salviae Miltiorrhizae can promoting blood circulation, it is inducing meastruation to relieve menalgia.Ginkgo leaf promoting blood circulation and stopping pain, for treating hyperlipidemia, hypertension, hat Angina pectoris.Corydalis tuber can invigorate blood circulation, promoting the circulation of qi, analgesic.Rhizoma Chuanxiong can blood-activating and qi-promoting, wind-expelling pain-stopping.Malt is with radix bupleuri etc., with controlling liver The obstruction of the circulation of vital energy is stagnant, Ben Fangzhong, it is preferred to use coloured malt.The moutan bark thoughts of returning home, liver and kidney channel, clearing heat and cooling blood, promoting blood circulation.Hawthorn can pass through Qi and blood has the work(of promoting blood circulation analgesic.Ginseng can reinforce vital energy, under certain condition can compatibility excrementum pteropi.Peach kernel enters conscience blood Point, kind to let out stasis, dissolving stasis power is strong, also known as stasis-breaking drug, to treat the common medicine of a variety of stagnation of blood stasis diseases.Safflower can blood-breaking, Promoting circulation of blood and blood adjust blood, strength to be better than safflower.Radix paeoniae rubra return liver warp, can clearing heat and cooling blood, removing blood stasis and analgesics can match radix bupleuri, moutan bark etc. It is medicinal.Caulis Spatholobi returns liver and kidney channel, can blood circulation promoting and enriching, menstruction regulating and pain relieving, Chang Peiwu qi and activate blood circulation dredging collateral medicines.Fructus Aurantii nature and flavor, channel tropism, Function is same with the dried immature fruit of citron orange, but acts on and relatively mitigating.Dried orange peel has pungent row temperature logical, there is the work(of promoting qi circulation and relieving pain, invigorating spleen.Artemisia anomala is good at going It dissipates, energy blood-breaking promoting menstruation, removing blood stasis and analgesics can match peach kernel, Radix Angelicae Sinensis, Rhizoma Chuanxiong etc..Radix Glycyrrhizae can coordinating the drug actions of a prescription, with the medicine of invigorating the spleen and benefiting qi such as ginseng Compatibility is used for the card of deficiency-weakness of spleen-QI.Radix Angelicae Sinensis can replenishing and activating blood, menstruction regulating and pain relieving, be used for arthralgia pain due to rheumatism.Radix Rehmanniae clearing heat and cooling blood, yin-nourishing It promotes the production of body fluid, controls consumption of YIN caused by febrile disease, radix polygonati officinalis can be matched.Radix polygonati officinalis can nourishing yin to moisten dryness, promote the production of body fluid to quench thirst.The moon is held back in Radix Paeoniae Alba blood-nourishing, and soft liver analgesic can match bavin Recklessly, Radix Angelicae Sinensis.The pungent row hardship of radix bupleuri is let out, and property is apt to item and reaches irritability, and soothing liver-qi stagnation, can control can control stagnation of QI due to depression of the liver.Longstamen Onion Bulb is with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae 5, control the card of the obstruction of qi in the chest.Campanulaceae facilitaing lung, eliminating the phlegm are distributed in lung channel.Dalbergia wood, which can dissipate, to manage it, can stagnation resolvation regulating qi-flowing for relieving pain, can be with controlling stagnation of QI and blood Chest side of body trusted subordinate pain, be equal with excrementum pteropi, Rhizoma Chuanxiong and use.Excrementum pteropi can promoting blood circulation and stopping pain, removing blood stasis and hemostasis specially enters Liver Channel blood system, is good at Promoting blood circulation, removing blood stasis and relieving pain, often with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae with use.Cassia twig controls heart arteries and veins stasis blocking, chest impediment and cardialgia.Radix Notoginseng can dissipate stasis of blood hemostasis, detumescence it is fixed Bitterly, with using, then the work(for analgesic therapy of invigorating blood circulation more writes compatibility blood-activating and qi-moving medicinal.The stem pith of the rice-paper plant attaches to the lung and stomach meridians, inducing diuresis for treating strangurtia, associates with Radix Glycyrrhizae etc.. Storax controls the diseases such as the turbid, blood stasis of phlegm, is often equal with borneol and uses.The borneol thoughts of returning home, spleen, lung channel, inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
The above pharmacology is abided by《Chinese Pharmacopoeia》(version in 2010) and《Chinese pharmacology》(New Century higher institutions of Chinese medicine is taught Material) herbal medicine efficacy and combination principle.But herbal pharmacology is profound, the summary of the above pharmacology and non-present invention whole pharmacology.We It is formed by a variety of compatibility of drugs, collective effect, Radix Salviae Miltiorrhizae, ginkgo leaf are monarch drug in a prescription, may also differentiate between monarch.
Embodiment one
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 21g, ginkgo leaf 18g, corydalis tuber 14.5g, Rhizoma Chuanxiong 14.5g, malt 12.9g, moutan bark 12.9g, hawthorn 12.9g, ginseng 11g, peach kernel 11g, safflower 11g, radix paeoniae rubra 11g, Caulis Spatholobi 11g, Fructus Aurantii 9g, dried orange peel 8.6g, Artemisia anomala 8.6g, Radix Glycyrrhizae 8.6g, Radix Angelicae Sinensis 8.6g, Radix Rehmanniae 8.6g, radix bupleuri 8.6g, dalbergia wood 8g, Radix Paeoniae Alba 8g, Longstamen Onion Bulb 8g, campanulaceae 8g, stem pith of the rice-paper plant 7g, excrementum pteropi 6g, cassia twig 6g, radix polygonati officinalis 6g, Radix Notoginseng 6g, storax 5g, borneol 0.8g.
A kind of Chinese medicinal pill for treating cardiovascular stasis coronary heart disease, including the Chinese medicine preparation and honey, mass ratio It is 1:~1.5.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is rice wine, and by mass percentage, the proportioning with Chinese medicine preparation is 1:8.
Embodiment two
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 20g, ginkgo leaf 20g, corydalis tuber 14g, Rhizoma Chuanxiong 14g, malt 12.5g, moutan bark 12.5g, hawthorn 12.5g, ginseng 10g, peach Benevolence 10g, safflower 10g, radix paeoniae rubra 10g, Caulis Spatholobi 10g, Fructus Aurantii 10g, dried orange peel 10g, Artemisia anomala 9g, Radix Glycyrrhizae 9g, Radix Angelicae Sinensis 9g, Radix Rehmanniae 9g, radix bupleuri 9g, dalbergia wood 10g, Radix Paeoniae Alba 8g, Longstamen Onion Bulb 8g, campanulaceae 8g, stem pith of the rice-paper plant 6g, excrementum pteropi 6g, cassia twig 6g, radix polygonati officinalis 6g, Radix Notoginseng 6g, Storax 4g, borneol 1g.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is ethyl alcohol, and by mass percentage, the proportioning with Chinese medicine preparation is 1:3.
Embodiment three
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 20.5g, ginkgo leaf 20g, corydalis tuber 14g, Rhizoma Chuanxiong 13.8g, malt 12.5g, moutan bark 12.5g, hawthorn 12.5g, ginseng 10g, peach kernel 10g, safflower 10g, radix paeoniae rubra 10g, Caulis Spatholobi 10g, Fructus Aurantii 10g, dried orange peel 10g, Artemisia anomala 8.8g, Radix Glycyrrhizae 8.6g, Radix Angelicae Sinensis 8.6g, Radix Rehmanniae 8.8g, radix bupleuri 8.6g, dalbergia wood 9g, Radix Paeoniae Alba 8.5g, Longstamen Onion Bulb 8.2g, campanulaceae 8.2g, stem pith of the rice-paper plant 6.5g, excrementum pteropi 5.9g, cassia twig 5.8g, radix polygonati officinalis 5.8g, Radix Notoginseng 5.8g, storax 4.5g, borneol 0.9g.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is ethyl alcohol, and by mass percentage, the proportioning with Chinese medicine preparation is 1:6.
Example IV
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 20g, ginkgo leaf 21g, corydalis tuber 13.5g, Rhizoma Chuanxiong 14.5g, malt 12g, moutan bark 12g, hawthorn 12g, ginseng 10.5g, peach Benevolence 10.5g, safflower 10.5g, radix paeoniae rubra 10.5g, Caulis Spatholobi 10.5, Fructus Aurantii 11g, dried orange peel 11g, Artemisia anomala 8.9g, Radix Glycyrrhizae 8.9g, Radix Angelicae Sinensis 8.9g, Radix Rehmanniae 8.9g, radix bupleuri 8.9g, dalbergia wood 11g, Radix Paeoniae Alba 9g, Longstamen Onion Bulb 8.5g, campanulaceae 8.5g, stem pith of the rice-paper plant 5.5g, excrementum pteropi 5.8g, cassia twig 5.5g, radix polygonati officinalis 5.5g, Radix Notoginseng 5.5g, storax 4g, borneol 1g.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is ethyl alcohol, and by mass percentage, the proportioning with Chinese medicine preparation is 1:1.
Embodiment five
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 21g, ginkgo leaf 21g, corydalis tuber 15g, Rhizoma Chuanxiong 15g, malt 12g, moutan bark 12g, hawthorn 12g, ginseng 10g, peach kernel 10g, Safflower 10g, radix paeoniae rubra 10g, Caulis Spatholobi 10g, Fructus Aurantii 10g, dried orange peel 10g, Artemisia anomala 9g, Radix Glycyrrhizae 9g, Radix Angelicae Sinensis 9g, Radix Rehmanniae 9g, bavin Hu 9g, dalbergia wood 10g, Radix Paeoniae Alba 8g, Longstamen Onion Bulb 8g, campanulaceae 8g, stem pith of the rice-paper plant 6g, excrementum pteropi 6g, cassia twig 6g, radix polygonati officinalis 6g, Radix Notoginseng 6g, storax 4g, borneol 2g.
It is a kind of for treating the Chinese medicinal pill of cardiovascular stasis coronary heart disease, which is characterized in that including the Chinese medicine preparation and Honey, mass ratio 1:1.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is yellow rice wine, and by mass percentage, the proportioning with Chinese medicine preparation is 1:10.
Embodiment six
A kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease consists of the following compositions according to the mass fraction:It is red Join 21g, ginkgo leaf 21g, corydalis tuber 13g, Rhizoma Chuanxiong 13g, malt 12g, moutan bark 12g, hawthorn 12g, ginseng 10g, peach kernel 10g, Safflower 10g, radix paeoniae rubra 10g, Caulis Spatholobi 10g, Fructus Aurantii 10g, dried orange peel 10g, Artemisia anomala 9g, Radix Glycyrrhizae 9g, Radix Angelicae Sinensis 9g, Radix Rehmanniae 9g, bavin Hu 9g, dalbergia wood 10g, Radix Paeoniae Alba 8g, Longstamen Onion Bulb 8g, campanulaceae 8g, stem pith of the rice-paper plant 6g, excrementum pteropi 6g, cassia twig 6g, radix polygonati officinalis 6g, Radix Notoginseng 6g, storax 6g, borneol 2g.
It is a kind of for treating the Chinese medicinal pill of cardiovascular stasis coronary heart disease, which is characterized in that including the Chinese medicine preparation and Honey, mass ratio 1:0.5.
It is a kind of for treating the Chinese medicine preparation of cardiovascular stasis coronary heart disease, it is characterised in that including the Chinese medicine preparation and molten Agent.In the Chinese medicine preparation, the solvent is rice wine, and by mass percentage, the proportioning with Chinese medicine preparation is 1:10.
The dosage of each traditional Chinese medicinal components of above example does not represent one dosage, in practical operation, it is general be divided to it is two daily. The application does not limit the preparation method of the Chinese medicine preparation, according to Chinese Pharmacopoeia, prepares, takes according to usual method.Certainly, According to experimental demonstration, ginseng and excrementum pteropi use aqueous solution or drinks of the concentration of alcohol 40% or more, are cooked by slow fire three hours, It is eaten with other components compatibility, it is better.
Typical case
1, sieve family in Nanchang City, Jiangxi Province collects sieve XX, and long-term pectoralgia enters Night Watch very, and with palpitation and uneasiness.Once in Jiangxi Province First Affiliated Hospital Of Nanchang University sees a doctor, and inspection result is treatment cardiovascular stasis coronary heart disease angina pectoris.Because of curative effect unobvious, chest Pain does not improve, and actively abandons curing.After our half a year, pectoralgia does not recur.
2, Jiangxi Duchang County Cai Ling town XXX, with hypertension and with long-term pectoralgia, Zeng Douchang county people's hospital treats, It is transferred to First Affiliated Hospital Of Nanchang University of Jiangxi Province after invalid.It determines in an attached institute and is twisted with the coronary heart disease heart caused by hypertension Bitterly, main dialectical type is type of obstruction of heart-blood.Due to many reasons, abandon treating.We are used the year before, by more than ten The long-term treatment of the moon, pectoralgia gradually slow down, have disappeared, and hypertension is alleviated.
Each traditional Chinese medicinal components of above example can be used for treating cardiovascular stasis coronary heart disease angina pectoris.It is to the painstaking effort stasis of blood The cure rate of coronary disease and angina pectoris based on resistance is about 90%, if coronary heart disease, caused by hypertension and hyperlipidemia, cure rate is about It is 92%.In addition, to causing the cure rate of anginal hypertension and hyperlipidemia to be about 76%.

Claims (4)

1. a kind of Chinese medicine for treating cardiovascular stasis coronary heart disease, which is characterized in that according to the mass fraction, by following component group At:210 parts of Radix Salviae Miltiorrhizae, 180 parts of ginkgo leaf, 145 parts of corydalis tuber, 145 parts of Rhizoma Chuanxiong, 129 parts of malt, 129 parts of moutan bark, hawthorn 129 Part, 110 parts of ginseng, 110 parts of peach kernel, 110 parts of safflower, 110 parts of radix paeoniae rubra, 110 parts of Caulis Spatholobi, 90 parts of Fructus Aurantii, 86 parts of dried orange peel, Liu Post 86 parts of slave, 86 parts of Radix Glycyrrhizae, 86 parts of Radix Angelicae Sinensis, 86 parts of Radix Rehmanniae, 86 parts of radix bupleuri, 80 parts of dalbergia wood, 80 parts of Radix Paeoniae Alba, 80 parts of Longstamen Onion Bulb, campanulaceae 80 parts, 70 parts of the stem pith of the rice-paper plant, 60 parts of excrementum pteropi, 60 parts of cassia twig, 60 parts of radix polygonati officinalis, 60 parts of Radix Notoginseng, 50 parts of storax, 8 parts of borneol, the wheat Bud is coloured malt.
2. a kind of Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease, which is characterized in that in as described in claim 1 Medicine.
3. a kind of Chinese medicinal pill for treating cardiovascular stasis coronary heart disease, which is characterized in that in as described in claim 1 Medicine and honey, mass ratio 1:0.5~1.5.
4. a kind of Chinese medicine preparation for treating cardiovascular stasis coronary heart disease, it is characterised in that in as described in claim 1 Medicine and solvent.
CN201810661787.4A 2018-06-25 2018-06-25 Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease Withdrawn CN108478731A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943901A (en) * 2016-05-10 2016-09-21 青岛市第三人民医院 Traditional Chinese medicinal preparation for treating chest congestion after heart bypass
CN110016397A (en) * 2019-05-14 2019-07-16 孙建德 The preparation method of the not bright heart-nourishing liquor of one seed sand
CN113750064A (en) * 2021-09-09 2021-12-07 牛鸿祥 A Chinese medicinal pill for treating cardiovascular diseases
CN115282229A (en) * 2022-07-05 2022-11-04 保定中药制药股份有限公司 Traditional Chinese medicine composition for treating coronary heart disease with syndrome of qi deficiency and blood stasis and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943901A (en) * 2016-05-10 2016-09-21 青岛市第三人民医院 Traditional Chinese medicinal preparation for treating chest congestion after heart bypass
CN110016397A (en) * 2019-05-14 2019-07-16 孙建德 The preparation method of the not bright heart-nourishing liquor of one seed sand
CN113750064A (en) * 2021-09-09 2021-12-07 牛鸿祥 A Chinese medicinal pill for treating cardiovascular diseases
CN115282229A (en) * 2022-07-05 2022-11-04 保定中药制药股份有限公司 Traditional Chinese medicine composition for treating coronary heart disease with syndrome of qi deficiency and blood stasis and preparation method thereof
CN115282229B (en) * 2022-07-05 2023-09-29 保定中药制药股份有限公司 Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof

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