CN108465163A - Pencil beam Response characteristics based on density transform - Google Patents
Pencil beam Response characteristics based on density transform Download PDFInfo
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- CN108465163A CN108465163A CN201810260086.XA CN201810260086A CN108465163A CN 108465163 A CN108465163 A CN 108465163A CN 201810260086 A CN201810260086 A CN 201810260086A CN 108465163 A CN108465163 A CN 108465163A
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- 230000004044 response Effects 0.000 title claims abstract description 13
- 238000009826 distribution Methods 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002715 modification method Methods 0.000 claims abstract description 7
- 239000004744 fabric Substances 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 238000004364 calculation method Methods 0.000 abstract description 7
- 238000001959 radiotherapy Methods 0.000 abstract description 7
- 230000003247 decreasing effect Effects 0.000 abstract description 2
- 238000004980 dosimetry Methods 0.000 abstract description 2
- 238000003672 processing method Methods 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Measurement Of Radiation (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a kind of pencil beam Response characteristics based on density transform, arbitrary ource-skin Distance is amplified to standard ource-skin Distance by geometric dimension, density inverse proportion scales, to be changed into the dosage distribution for being irradiated to other density die bodys under standard ource-skin Distance, the dosage for finally being distributed to obtain arbitrary radiographic source and arbitrary density die body from standard water mould dosage using heterogeneity modification method is distributed.Using O ' Connor theorems, by pencil beam, the dosage distribution shifts under different ource-skin Distances are that the dosage under identical ource-skin Distance different densities is distributed to the present invention, then the relationship between dosage distribution is obtained using density revision, this method makes Rapid Dose Calculation without preparing multiple cores, the error for decreasing interpolation simultaneously solves common Pencil beam algorithm in Radiotherapy dosimetry calculating and needs to handle the dosage distribution problem of pencil beam under different ource-skin Distances.
Description
Technical field
The present invention relates to the Rapid Dose Calculation fields in tumour radiotherapy, more particularly to a kind of pen based on density transform
Pencil of forms Response characteristics.
Background technology
Rapid Dose Calculation is that the basis in radiotherapy is crucial, and beam of radiation can accurately be calculated in people by formulating radiotherapy planning needs
Dosage distribution in body, to reasonably formulate radiotherapy planning.Clinically a main method of Rapid Dose Calculation is that pencil beam is calculated
Radiotherapy is decomposed into the pencil beam of multiple very littles by method, the algorithm with beam, calculates separately the dosage distribution of each pencil beam, then
It is overlapped to obtain total dosage distribution.Vertically enter so crucially calculating very much single pencil beam in pencil beam Response characteristics
Penetrate dosage distribution in water, referred to as core.The form of core includes analytical form and tables of data, and the latter, which can pass through, covers snap gauge
Intend or is obtained according to the methods of measurement data deconvolution.But whether being the core of which kind of form, not homologous skin will be considered
Influence away from (distance on the die body surface that i.e. radioactive source to pencil beam irradiates).Identical pencil beam is under different ource-skin Distances, radiation
Significant difference is distributed in dosage, but the dosage distribution between different ource-skin Distances is not associated with simply, it is difficult to from a standard source
Dosage of the skin away under is distributed to obtain the distribution of the dosage under any ource-skin Distance.If respectively obtaining the core dosage under each ource-skin Distance
Distribution, and is made as database, and for Rapid Dose Calculation using the database into if row interpolation, the data volume needed is excessive and excessively numerous
It is trivial, and interpolation method cannot be fitted actual distribution well in the bigger place of dosage distribution gradient.
Therefore it is urgent to provide a kind of novel pencil beam Response characteristics to solve the above problems.
Invention content
Technical problem to be solved by the invention is to provide a kind of pencil beam Response characteristics based on density transform, can make
Rapid Dose Calculation decreases the error of interpolation without preparing multiple cores.
In order to solve the above technical problems, one aspect of the present invention is：It provides a kind of based on density transform
Arbitrary ource-skin Distance is amplified to standard ource-skin Distance, density inverse proportion scaling, to change by pencil beam Response characteristics by geometric dimension
To be irradiated to the dosage distribution of other density die bodys under standard ource-skin Distance, finally utilize heterogeneity modification method from standard water mould
The dosage that dosage is distributed to obtain arbitrary radiographic source and arbitrary density die body is distributed.
In a preferred embodiment of the present invention, the pencil beam Response characteristics based on density transform, including walk as follows
Suddenly：
If there are one the pencil beam of given size, radiographic source is gauged distance SSD, pencil beam irradiation with die body distance
For dosage distribution F (d, x, y) on Water ball it is known that wherein d indicates to calculate the depth of point, x, y indicate to calculate point apart from pen shape
Shown in the distance of beam center axis such as Fig. 1 (c).It needs to calculate identical pencil beam, the dosage point of radiographic source and the situation of die body distance h
Cloth remembers that the dosage is distributed as G (d, x, y) as shown in Fig. 1 (a).
Dosage distribution under radiation scene any first, if its geometric dimension and density inverse ratio were scaled, and ray would be strong
Degree is also scaled with the inverse ratio of geometric dimension square, then dosage distribution is constant.So radiographic source and the agent in the case of die body distance h
Amount distribution is equivalent to pencil beam and is radiated at density at gauged distanceDie body under dosage distribution, as shown in Fig. 1 (b),
Remember that the dosage is distributed as S (d, x, y), then
S (d, x, y) is obtained from F (d, x, y) using heterogeneity processing method, because Fig. 1 (b) and (c) two kinds of situations are only
There is density different, it is possible to by the heterogeneities such as equivalent path or Batho methods modification method from pencil beam in water mould
Dosage is distributed to obtainDosage distribution under density die body, utilizes the density relationship apart from invertendo and two kinds of situations
It can obtain
Arbitrary radiographic source is obtained using the relationship of above-mentioned G (d, x, y) and S (d, x, y) to be distributed with the dosage under die body distance h
G(d,x,y)。
The beneficial effects of the invention are as follows：Using O ' Connor theorems, by pencil beam, the dosage under different ource-skin Distances divides the present invention
Cloth is changed into the distribution of the dosage under identical ource-skin Distance different densities, then obtains the pass between dosage distribution using density revision
System, this method makes Rapid Dose Calculation without preparing multiple cores, while decreasing the error of interpolation, solves Radiotherapy dosimetry calculating
In common Pencil beam algorithm need to handle the dosage distribution problem of pencil beam under different ource-skin Distances.
Description of the drawings
Fig. 1 is the process schematic of one preferred embodiment of pencil beam Response characteristics the present invention is based on density transform.
Specific implementation mode
The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, so that advantages and features of the invention energy
It is easier to be readily appreciated by one skilled in the art, so as to make a clearer definition of the protection scope of the present invention.
Referring to Fig. 1, by taking rectangle pencil beam, Batho heterogeneity modification methods as an example, illustrate how existing standard
The non-standard pen shape beam dose distribution under of pencil beam dose distributions computation under.
Pencil beam in the case of known standard ource-skin Distance is radiated at dosage distribution when Water ball, is denoted as F (d, x, y), d tables
Show that the depth for calculating point, x, y indicate to calculate distance of the point apart from pencil beam central shaft.Under the known pencil beam field size most
Big tissue air ratio (Tissue Maximum Ratio, TMR), is denoted as TMR (A, d), and wherein A indicates field size.
Onesize pencil beam being irradiated in the case of the die body of distance sources h, dosage distribution is denoted as G (d, x, y),
Radiographic source is equivalent to pencil beam with the dosage distribution in the case of die body distance h and is radiated at gauged distance SDD first
Locating density isDie body under dosage distribution, remember that the dosage is distributed as S (d, x, y), then
S (d, x, y) can be obtained from F (d, x, y) by carrying out heterogeneity processing method using Batho modification methods,
It can be obtained by above-mentioned relation
Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair
Equivalent structure or equivalent flow shift made by bright specification and accompanying drawing content is applied directly or indirectly in other relevant skills
Art field, is included within the scope of the present invention.
Claims (3)
1. a kind of pencil beam Response characteristics based on density transform, which is characterized in that amplify arbitrary ource-skin Distance by geometric dimension
To standard ource-skin Distance, density inverse proportion scaling, to be changed into the dosage point for being irradiated to other density die bodys under standard ource-skin Distance
Cloth is finally distributed to obtain the agent of arbitrary radiographic source and arbitrary density die body from standard water mould dosage using heterogeneity modification method
Amount distribution.
2. the pencil beam Response characteristics according to claim 1 based on density transform, which is characterized in that including walking as follows
Suddenly：
If there are one the pencil beam of known dimensions, radiographic source is gauged distance SSD with die body distance, which is radiated at water
For dosage distribution F (d, x, y) on die body it is known that wherein d indicates to calculate the depth of point, x, y indicate to calculate point in pencil beam
The distance of mandrel；
For identical pencil beam, radiographic source is denoted as G (d, x, y) with the dosage distribution under die body distance h situations；Radiographic source and die body
Dosage distribution under distance h situations is equivalent to pencil beam and is radiated at density at gauged distanceDie body under dosage point
Cloth remembers that the dosage is distributed as S (d, x, y), then
S (d, x, y) is obtained from F (d, x, y) using heterogeneity modification method, using apart from invertendo and identical standard source skin
Relationship away from two kinds of density situations can obtain
Obtained using the relationship of above-mentioned G (d, x, y) and S (d, x, y) under arbitrary radiographic source and die body distance h dosage distribution G (d,
x,y)。
3. the pencil beam Response characteristics according to claim 1 based on density transform, which is characterized in that any radiation scene
Under dosage distribution, if its geometric dimension and density inverse ratio scaling, and transmitted intensity with geometric dimension square inverse ratio scale, then
Dosage distribution is constant.
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| CN201810260086.XA CN108465163B (en) | 2018-03-27 | 2018-03-27 | Pencil beam dose algorithm based on density transformation |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5291404A (en) * | 1990-04-18 | 1994-03-01 | Mitsubishi Denki Kabushiki Kaisha | Radiotherapy treatment planning system |
| CN101120871A (en) * | 2006-12-29 | 2008-02-13 | 成都川大奇林科技有限责任公司 | Precise radiotherapy planning system |
| CN103083820A (en) * | 2013-01-13 | 2013-05-08 | 中国科学院合肥物质科学研究院 | Dosage leading and accurately emitting treatment system |
| CN106714906A (en) * | 2015-03-31 | 2017-05-24 | 光线搜索实验室公司 | Method, computer program and system for dose calculation in radiotherapy |
-
2018
- 2018-03-27 CN CN201810260086.XA patent/CN108465163B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5291404A (en) * | 1990-04-18 | 1994-03-01 | Mitsubishi Denki Kabushiki Kaisha | Radiotherapy treatment planning system |
| CN101120871A (en) * | 2006-12-29 | 2008-02-13 | 成都川大奇林科技有限责任公司 | Precise radiotherapy planning system |
| CN103083820A (en) * | 2013-01-13 | 2013-05-08 | 中国科学院合肥物质科学研究院 | Dosage leading and accurately emitting treatment system |
| CN106714906A (en) * | 2015-03-31 | 2017-05-24 | 光线搜索实验室公司 | Method, computer program and system for dose calculation in radiotherapy |
Non-Patent Citations (2)
| Title |
|---|
| 宋钢 等: "基于混合Batho修正的RBM剂量计算方法在仿真头模实验中的剂量学验证", 《原子核物理评论》 * |
| 张鹏程: "精确放射治疗剂量计算及方案优化方法研究", 《万方--中国学位论文全文数据库》 * |
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