CN108434346A - It is a kind of for adjust, the herbal cuisine composition and preparation method thereof of auxiliary hyperglycemic - Google Patents
It is a kind of for adjust, the herbal cuisine composition and preparation method thereof of auxiliary hyperglycemic Download PDFInfo
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Abstract
The present invention provides a kind of for adjusting, the herbal cuisine composition of auxiliary hyperglycemic, its material composition includes compound for reducing blood suger, conditioning composition and toxin expelling composition, each component accounts for the proportion in total raw material, compound for reducing blood suger is 40% 60%, conditioning composition is 30% 50%, and toxin expelling composition is 1% 20%；Wherein, compound for reducing blood suger includes balsam pear, mulberry leaf, pueraria lobata and L arabinoses, balsam pear：(mulberry leaf+pueraria lobata)：Arabinose=2 L：2.2：1.1；Conditioning composition includes mulberry fruit, Radix Astragali, ginseng, Poria cocos and sealwort, mulberry fruit：(Radix Astragali+Poria cocos+sealwort)：Ginseng=1：5：1.6；Toxin expelling composition includes corn stigma.The present invention also provides the preparation methods of the herbal cuisine composition.Each component rationally compounds in the present invention, and collaboration reduces blood glucose, improves function of reducing blood sugar and filling liver kidney, invigorating the blood various aspects adjust body, improve immunity, the cure rate for improving diabetes is up to 98%.
Description
Technical field
The present invention relates to Chinese medicine and field of health care food more particularly to it is a kind of for adjust, the herbal cuisine group of auxiliary hyperglycemic
Close object and preparation method thereof.
Background technology
Diabetes are a kind of chronic diseases, and there are about 1,500,000 people directly to die of this disease in total within 2012, wherein 80% or more
Death be happened at low income and middle income country.It is predicted according to World Health Organization, to the year two thousand thirty, diabetes will become the 7th
Item major causes of death.There are two types of principal modes for diabetes.Type 1 diabetes patient generally can not oneself excreting insulin, therefore
Insulin injection is needed to sustain life.Diabetes B accounts for 90% or so of diabetes cases sum, and patient usually oneself can
Insulin is generated, but enough insulin cannot be generated or can not properly be utilized.
Currently, the hypoglycemic market in China accounts for about the 73.68% of whole market share based on synthetic drug；But long-term clothes
Drug resistance, drug resistance, lesions of liver and kidney for being easily caused with synthetic drug etc..And in about 26% natural drug market, selection
Natural drug formula is most not reasonable, and cannot reduce blood glucose from many aspects.
Invention content
The purpose of the present invention is to provide a kind of for adjusting, the herbal cuisine composition of auxiliary hyperglycemic, on the one hand has control
Human body processed absorbs the conversion of sugar the effect with enhancing insulin, can cooperate with reduction blood glucose, and improve immunity of organisms；It is another
Aspect, prescription select the simple raw material of ingredient, are easy to absorb, and do not allow to be also easy to produce dependence.
Another object of the present invention is to provide a kind of for adjusting, the preparation side of the herbal cuisine composition of auxiliary hyperglycemic
Method combines zymotechnique with extraction process, and the intermediate material of macromolecular, decomposition and inversion, which becomes, directly to be absorbed
Effective small-molecule substance, thoroughly release drug detrimental toxicities, and eliminate the defect of traditional Chinese medicine decoction " bitter to the taste ", features good taste
Turn, patient can take for a long time.Therefore, curative effect is fast, definite effect, realizes Chinese Herbs speed-raising, attenuation synergistic, improves mouth
Sense, the preparation method technological process is short, can ferment under room temperature, is not required to stringent process conditions, and operability is strong, is conducive to industry
Metaplasia is produced.
The present invention solves its technical problem using following technical scheme to realize：
The present invention provide it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, material composition include hypoglycemic combination
Object, conditioning composition and toxin expelling composition, each component account for the proportion in total raw material, and the compound for reducing blood suger is 40%-60%, is adjusted
Reason composition is 30%-50%, and toxin expelling composition is 1%-20%；
Wherein, the compound for reducing blood suger includes balsam pear, mulberry leaf, pueraria lobata and L-arabinose, balsam pear：(mulberry leaf+pueraria lobata)：L-
Arabinose=2：2.2：1.1；
The conditioning composition includes mulberry fruit, Radix Astragali, ginseng, Poria cocos, sealwort, mulberry fruit：(Radix Astragali+Poria cocos+sealwort)：Ginseng
=1：5：1.6；
The toxin expelling composition includes corn stigma.
The present invention also provides it is a kind of it is described for adjusting, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic, including
Following steps：
Step 1 weighs the raw material such as the number, and in addition to mulberry leaf, corn stigma and L-arabinose, other raw material mixings add
Enter in culture medium, access strain, ferment 20-30 days at normal temperatures, repeat fermentation three times, obtains herb fermenting object；
Step 2 mixes mulberry leaf with corn stigma, after adding water to cook, is extracted with water, and obtains Chinese medical extract；
It step 3, the Chinese medicine extract for taking step (2) to prepare and is carried out to mixing in Chinese medicine fermented liquid in step (1) even
After matter, L-arabinose is added and forms Chinese medicine composition；
Step 4 sterilizes after the Chinese medicine composition of gained in step 3 is packed or bottled.
Activity is as follows the effect of each primary raw material medicine in the present invention：
1, balsam pear：With significant hypoglycemic effect.Wherein, the substance with hypoglycemic activity is polypeptide in balsam pear
Matter, glycoside substance and Flavonoid substances, polypeptide moiety especially therein more have " plant pancreas islet because its blood sugar reducing function is notable
The title of element ", the main mechanism of balsam pear hypoglycemic are：Bitter gourd polypeptide enhances INSULIN A chain and B chains by distinctive space structure
Between two disulfide bond stability, induce the insulin of low activity to reply its activity space structure, to activate insulin, enhancing
Its compatibility to insulin receptor α subunits and β subunits on cell membrane, stimulating activity β cells secrete insulins and para-insulin
Effect, insulin can promote uptake and utilization of the body tissue to glucose, and inhibit decomposition and the gluconeogenesis of glycogen, because
This, pancreas islet is known as the effect for reducing blood glucose.
2, mulberry leaf：1-Deoxynojirimycin, alkaloid, polysaccharide hypoglycemic in mulberry leaf is most strong, and the hypoglycemic effect of mulberry leaf is logical
Cross what two approach were realized：First, decomposing enzymatic activity to disaccharides by alkaloid DNJ (1-DNJ) generates inhibition
Effect reduces the peak value (Kimura, 1995) of blood glucose after food to inhibit absorption of the small intestine to disaccharide；Second is that passing through mulberry leaf
Alkaloid fagomine and mulberry leaf polysaccharide promote β cells point must insulin, and insulin can promote utilization of the cell to sugar, liver
Glycogen synthesis and improvement glycometabolism, are finally reached hypoglycemic effect (Chen Fujun etc., 1996).
3, pueraria lobata：Main function is to consolidate, antipyretic anti-inflammatory, reduces blood glucose.Puerarin in pueraria lobata can inhibit α-grape
Decomposition of the glycosidase to substrate 4- nitrophenol-α-D- glucopyranosides, i.e. Puerarin can be mutual with alpha-glucosidase
Effect, to inhibit its activity, wherein alpha-glucosidase that can cut α-Isosorbide-5-Nitrae glucosides from the non-reducing end of oligosaccharides substrate
Key releases glucose.Puerarin reduces the activity of alpha-glucosidase, prolongs as the potential inhibitor of alpha-glucosidase
The release of slow glucose, reduces level of postprandial blood sugar.
4, L-arabinose, main physiological action be block sucrose decomposition, in small intestine disaccharide-hydrolysing enzymes class with sugarcane
Sugar digests the strong selective depression of relevant enzyme, it is suppressed that the carbohydrate breakdown of intake is the speed of glucose and fructose
Degree and efficiency, to reduce absorption of the small intestine to glucose and fructose, L-arabinose, which has, promotes small intestine site to calcium
Absorption, and high calcium intake can reduce absorption and the lipid-metabolism of intestinal fat, reduce the same of adipocyte Ca2+ influx
When may also inhibit Ca2+ influx in liver cell, the synthesis of very low density lipoprotein (V-LDL) is reduced, to reducing by its conversion
The low-density lipoprotein (LDL) come.In the present invention, the L- Arab pool is alternatively arranged as sweetener.
5, Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial
Effect.Belong to warm nature, is common Chinese medicine simply.Its main pharmacological is " invigorating qi for consolidating superficies ", and invigorating the blood is to push qi and blood
Operation, can " Li Shui ", can also " promoting pus discharge and tissue regeneration ".Radix Astragali have invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema it
Effect.For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back,
Blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..Radix Astragali invigorating middle warmer and replenishing QI, raw solid table torr sore.
6, mulberries have immunologic enhancement.Mulberry fruit has effect of gain to spleen, has humidification to hemolytic reaction,
Human body artery hardening, skeletal joint hardening can be prevented, is boosted metabolism.It can promote the growth of erythrocyte, prevent white
Leukopenia, and have effects that auxiliary to illnesss such as treatment diabetes, anaemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia.
Mulberry fruit has the effects that promote the production of body fluid to quench thirst, promotes digestion, helps defecation, proper amount of edible that can promote gastric secretion, stimulate enterocinesia and
It releases scorching.Motherland's medicine thinks that mulberry fruit is sweet in flavor and cold in property, has liver-kidney tonifying, ease constipation of promoting the production of body fluid, UFA eyesight and other effects.
7, Poria cocos：Enhance body's immunity, contained pachymic acid has strengthen immunity, antitumor and calm, drop blood
The effect of sugar etc., pachymaran have apparent antitumor and liver protecting effect, and can relax gastrointestinal smooth muscle, gastric acid inhibitory point
It secretes, prevents necrosis of liver cells, antibacterial and other effects.Poria cocos is sweet in flavor, light, mild-natured, is used as medicine with clearing damp and promoting diuresis, beneficial spleen and stomach, calming heart
The function of tranquilizing the mind.
8, sealwort：Resisting pathogenic microbes, antiviral effect；Huang jing extract is excessively high to blood glucose caused by adrenaline to be manifested
Write inhibiting effect；Has the function of antifatigue, anti-oxidant, anti-aging.It is used as medicine with rhizome, there is boosting qi and nourishing yin, invigorating the spleen, profit
Lung, kidney benefiting functions.It is weakness of the spleen and the stomach for treating, fatigue and asthenia, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, Heat Diabetes etc.
Disease.
9, ginseng：As the conditioning agent of body function, stem and leaf of Radix Ginseng saponin and root saponin to it is physical (cold, overheat,
Aggravating activities, radioactive ray), (foreign serum, bacterium, the transplantation tumor) of biology, chemically (poisonous substance, arcotic, swash
Element, anticarcinogen etc.) stress reaction caused by various stimulations has protective effect, and disorderly functional recovery can be made normal, there is person
It is to adapt to immunogenic substance (a kind of substance of enhancing human body non-specificity resistivity), and ginseng saponin Rh 2 is that ginseng moderate resistance is swollen
The best ingredient of tumor effect is usually used in more afterwards restoring, enhances muscle power, adjusts hormone, reducing blood glucose and control blood pressure, control liver
Index and liver function health care etc..
10, Cordyceps militaris：Also known as cordyceps sinensis, have the function of to adjust whole body, improves immunocompetence, enhances gulping down for macrophage
The formation bitten function, promote antibody mainly has the nourishing the liver of guarantor's lung kidney-nourishing, relieving cough and asthma eliminating the phlegm, the wrinkle resistant anti-aging of moisturizing, antibacterial anti-
It is scorching, calm, expansion blood vessel, reduce blood pressure, reduce blood glucose, is antifatigue, resist oxygen lack the effects that.Chinese medicine thinks that it acts work of strengthening the body resistance to consolidate the constitution
With, there is significant curative effect to chronic senile bronchitis, cor pulmonale, liver detoxification ability can be improved, plays liver protection effect,
Improve that body is antiviral and capability of resistance to radiation.Cordyceps sinensis enters lung kidney two warp, can tonifying lung is cloudy and kidney-replenishing, cure mainly kidney deficiency, impotence
Seminal emission, soreness of waist and knee joint, eak after being ill, chronic cough are weak, phthisical cough phlegm blood, spontaneous sweating etc., are that unique a kind of can balance, adjust simultaneously
Save the Chinese medicine of negative and positive.
11, corn stigma：Have the function of diuresis, the herbal cuisine for treating diabetes, reducing blood lipid.It is sweet in flavor, light, it is mild-natured；Return kidney,
Liver, gallbladder channel；It is light to ooze drop.With inducing diuresis to remove edema, the effect of calm the liver and benefit the lungs.Cure mainly oedema, dribbling urination, jaundice, cholecystitis, courage
Calculus, high blood pressure, diabetes, alactation.Saponins in corn stigma have played blood sugar reducing function, in addition in corn stigma
Also contain chromium, chromium is the component part of the sugar tolerance factor, can reinforce insulin function, the content of Flavonoid substances in corn stigma
It is 15 times of niblet, the generation of free radical can be reduced and remove free radical that there is good oxidation resistance, and corn
The ability that palpus water extract removes free radical is higher than isoflavones, can prevent diabetic complication.
The invention has the advantages that：
1, the raw material in the present invention belongs to the row of " integration of drinking and medicinal herbs " 88 products of health ministry promulgation, and has one
Fixed similar effect can generate the effect of plant general character, and common compatibility, which gets up to drink, can enhance food therapy effect；Chinese medicine formula is said
The principle for studying carefully monarch, minister, helping, making, the present invention have the characteristics that cold, heat, temperature, cool four attribute according to plant, according to it is cold, cool, warm,
The hot principle being collocated with each other has carried out the collocation of relative equilibrium according to attributes of vegetation to herbaceous plant：Balsam pear slice, mulberry leaf and Pueraria lobota
Root belongs to cold plant；Radix Astragali, mulberries, Panax warm nature plant play temperature compensation and the cold plant of reconciliation in formula, beautiful
Rice palpus, Poria cocos, sealwort belong to levelling plant, and the plant that reconciles in formula is cold, temperature attribute, auxiliary hyperglycemic, and such collocation makes
It is excessively not cold or hot to obtain hypoglycemic plant composition of the invention, side effect will not be caused to body, embody attributes of vegetation
Relative equilibrium, having reached in drop has benefit, bowl spares to have dietotherapy effect of drop, single plant composition compared with the prior art and
The herbal cuisine plant composition of speech, treatment diabetes of the invention can allow each plant to play balanced benefiting action, have better
Hypoglycemic, stabilizing blood sugar effect；
2, of the invention for adjusting, in the compound for reducing blood suger in the herbal cuisine composition of auxiliary hyperglycemic, why will be bitter
Melon, (mulberry leaf+pueraria lobata), L-arabinose distinguish, and are the hypoglycemic mechanism differences because of them,
The first, pueraria lobata extraction flavonoid substances are combined to form a kind of novel substance with mulberry-leaf extract 1-Deoxynojirimycin ---
It is plain (cics) to wash the clear sugar of pancreas, has the effects that hypoglycemic, blood fat, anti-inflammatory, wash pancreas element sugared clearly can will deposit in blood it is " malicious
Sugar " resolves into particulate, is allowed to penetrate into cell interior and is converted into energy, bidirectional modulation blood glucose (can reduce blood glucose also to increase
Blood glucose), restore itself to change sugared instinct, not only rests on the stage of desaccharification poison, but sugared poison is directly converted into saccharogenesis energy, it plays
Blood glucose as the various cell activities of human body must " energy source " real effect, release diabetes patient's " one side blood glucose
Occupy height does not drop, on the other hand, body energy lack " double predicament.Simple hypoglycemic is avoided only to engage in tokenism, it can not be from root
The ultimate of carbohydrate metabolism disturbance is solved the problems, such as in sheet, make blood glucose balance it is more natural, it is healthier, deeper into, quickly repair be damaged β it is thin
Born of the same parents make pancreatic cell regeneration, nutrition pancreas enhance human immunity；
The second, balsam pear main mechanism is that stimulating activity β cells secrete insulins and para-insulin act on, and insulin can promote
Uptake and utilization of the body tissue to glucose, and inhibit decomposition and the gluconeogenesis of glycogen；
Third, L-arabinose block sucrose decomposition, it is suppressed that the carbohydrate breakdown of intake is glucose and fructose
Speed and efficiency, to reduce absorption of the small intestine to glucose and fructose.
4th, each ingredient in compound for reducing blood suger complements each other：Balsam pear extracts flavonoid substances and mulberry-leaf extract deoxidation
Nojirimycin combines and forms a kind of novel substance --- the plain hypoglycemic effect of the clear sugar of pancreas is washed more preferably, by improving histiocytic insulin
Utilization rate and promotion sugar operating, while the secretion of insulin can be maintained, fasting blood-glucose is reduced, postprandial blood sugar can also be lowered,
And pancreas function can be protected；Pueraria lobata, which has the function of consolidating, to reinforce the kidney and hypoglycemic, L-arabinose and balsam pear, mulberry leaf, Pueraria lobota
Root can not only control human body and be absorbed to the conversion of sugar, moreover it is possible to increase secretion pancreas islet with the use of that can play the role of collaboration hypoglycemic
Element promotes glucose by histiocytic utilization.Therefore each group subassembly acts on significantly together and each component supplements and complements each other.
3, it is of the invention for adjusting, the conditioning composition in the herbal cuisine composition of auxiliary hyperglycemic, mulberry fruit, Radix Astragali, Fu
Siberian cocklebur, sealwort and ginseng have regulatory function, enhance body's immunity, why by mulberry fruit：(Radix Astragali+Poria cocos+sealwort)：(people
Ginseng+Cordyceps militaris)=1：5：3.2 distinguish in this way, because sealwort and Poria cocos belong to the alkalinity food of levelling (than negative and positive, than Yang Yin)
Object, it can improve acidic constitution to maintain the acid-base balance of human body, to enhance muscle power and disease resistance.In addition to neutralizing soda acid
Balance, moreover it is possible to increase satiety, food-intake can be reduced before meals by eating, and achieve the purpose that hypoglycemic；The basic effect of sealwort is nourishing
The moon of liver kidney, sealwort play the role of air making-up and spleen enlivening again, and sealwort and Radix Astragali can treat the deficiency of vital energy to a certain extent；Radix Astragali, Poria cocos one
Rise eat can tonifying Qi dehumidifying；The basic effect of mulberries is nourishing liver and kidney the moon, and mulberries are enriched blood again, mulberries tonifying liver
Kidney, nourishing yin and supplementing blood, fluid dryness, runchang detoxification.Ginseng mainly reinforces vital energy, prevent prolapse and engender liquid, calms the nerves；Cordyceps militaris can be mended
Lung yin, and energy kidney-replenishing are a kind of unique Chinese medicine that can balance, adjust negative and positive simultaneously.
4, of the invention for adjusting, in the herbal cuisine composition of auxiliary hyperglycemic, compound for reducing blood suger primary efficacy is to drop
Blood glucose, wherein each group subassembly number of ways carry out hypoglycemic；Conditioning composition, nourishing liver and kidney the moon, invigorating the blood, various aspects
It is to have good taste to human body to adjust body, improve immunity if being effectively combined conditioning composition and compound for reducing blood suger
Benefit acts on, and not only improves the function of reducing blood sugar of compound for reducing blood suger, moreover it is possible to improve the immunity of the human body；Corn in the toxin expelling composition
Must have effects that diuresis, blood pressure lowering, hypoglycemic, toxin expelling, additionally since hyperglycemic patients are typically the middle-aged and the old, constitution is natively
More cold and cool, most of expellant medicaments are all relatively colder, and corn stigma is mild-natured, and cold and cool burden will not be caused to human body；Pass through research
If causing to be easy to cause hypoglycemia, increasing blood pressure, influence human body to plant society it was found that the dosage of each component crosses conference
The problems such as absorption of object, if dosage is too small and formula can be made to lose attribute balance, temperature compensation effect is not achieved and can also weaken plant
Dietotherapy effect of compositions, just creatively propose the present invention for adjust, each group in the herbal cuisine composition of auxiliary hyperglycemic
The dosage divided, the selection collocation of this dosage makes the herbal cuisine herbal compositions for the treatment of diabetes can be right with long-term drinking
The dual food therapy effect that diabetic has stabilizing blood sugar, reduces blood glucose, can effectively prevent diabetic syndrome, have profession
Property and science, each component compounding it is synergistic, the rational compounding of each component can greatly improve the cure rate of diabetes,
Up to 98% or more；
5, it is of the invention for adjusting, the herbal cuisine composition of auxiliary hyperglycemic has been combined zymotechnique with extraction process
Come：The microorganism based on Chinese medicine and lactic acid bacteria is fermented with tank in Chinese medicine fermented liquid, predigestion is carried out to Chinese medicine, decomposes and turns
Change, the intermediate material of macromolecular, decomposition and inversion becomes the effective small-molecule substance that can be directly absorbed, and herb fermenting passes through
Predigestion and conversion are crossed, thoroughly releases drug detrimental toxicities, and eliminate the defect of traditional Chinese medicine decoction " bitter to the taste ", features good taste
Turn, patient can take for a long time.Therefore, curative effect is fast, definite effect, realizes Chinese Herbs speed-raising, attenuation synergistic, improves mouth
Sense, through Long-term clinical and it was verified that herb fermenting compare traditional Chinese medicine drug effect absorptivity raising 4-28 times；In the present invention
In medicament extracting solution, corn stigma and mulberry-leaf extract can inhibit the activity of Glucose Synthetase, can significantly reduce rat fasting blood-glucose,
Triglycerides, cholesterol, low-density lipoprotein and free fatty acid levels, increasing high density fatty acid levels.
Specific implementation mode
Embodiment 1
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：21 portions of balsam pears, 14.1 parts of mulberry leaf, 9 parts of pueraria lobatas, 11.55 parts of L-arabinoses；
Conditioning composition：5.5 parts of mulberries, 12 parts of Radix Astragalis, 7 parts of Poria cocos, 8.5 parts of sealworts, 8.8 parts of ginsengs；
Toxin expelling composition：2.55 part corn stigma.
2, it is described for adjusting, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic, include the following steps：
Step 1 weighs the raw material such as the number, and in addition to mulberry leaf, corn stigma and L-arabinose, other raw material mixings add
Enter in culture medium, access strain, ferment 20-30 days at normal temperatures, repeat fermentation three times, obtains herb fermenting object；
Step 2 mixes mulberry leaf with corn stigma, after adding water to cook, is extracted with water, and obtains Chinese medical extract；
It step 3, the Chinese medicine extract for taking step (2) to prepare and is carried out to mixing in Chinese medicine fermented liquid in step (1) even
After matter, L-arabinose is added and forms Chinese medicine composition；
Step 4 sterilizes after the Chinese medicine composition of gained in step 3 is packed or bottled.
Embodiment 2
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：20 portions of balsam pears, 13 parts of mulberry leaf, 9 parts of pueraria lobatas, 11 parts of L-arabinoses；
Conditioning composition：4 parts of mulberries, 8 parts of Radix Astragalis, 4 parts of Poria cocos, 8 parts of sealworts, 6.6 parts of ginsengs, 6.6 parts of Cordyceps militaris；
Toxin expelling composition：9.8 parts of corn stigmas.
2, it is described for adjusting, the preparation method is the same as that of Example 1 for the herbal cuisine composition of auxiliary hyperglycemic.
Embodiment 3
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：18 portions of balsam pears, 13 parts of mulberry leaf, 6.8 parts of pueraria lobatas, 9.9 parts of L-arabinoses；
Conditioning composition：4 parts of mulberries, 8 parts of Radix Astragalis, 3 parts of Poria cocos, 9 parts of sealworts, 6.4 parts of ginsengs, 6.4 parts of Cordyceps militaris；
Toxin expelling composition：15.5 part corn stigma.
2, it is described for adjusting, the preparation method is the same as that of Example 1 for the herbal cuisine composition of auxiliary hyperglycemic.
Embodiment 4
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：22 portions of balsam pears, 17 parts of mulberry leaf, 7.2 parts of pueraria lobatas, 12.1 parts of L-arabinoses；
Conditioning composition：5 parts of mulberries, 11 parts of Radix Astragalis, 6 parts of Poria cocos, 8 parts of sealworts, 8 parts of ginsengs；
Toxin expelling composition：3.7 parts of corn stigmas.
2, it is described for adjusting, the preparation method is the same as that of Example 1 for the herbal cuisine composition of auxiliary hyperglycemic.
Embodiment 5
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：18 portions of balsam pears, 13 parts of mulberry leaf, 6.8 parts of pueraria lobatas, 9.9 parts of L-arabinoses；
Conditioning composition：6.2 parts of mulberries, 12 parts of Radix Astragalis, 7 parts of Poria cocos, 12 parts of sealworts, 9.92 parts of ginsengs；
Toxin expelling composition：5.18 part corn stigma.
2, it is described for adjusting, the preparation method is the same as that of Example 1 for the herbal cuisine composition of auxiliary hyperglycemic.
Embodiment 6
1, it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, wherein material composition include compound for reducing blood suger, conditioning
Composition and toxin expelling composition, each component score meter by weight,
Compound for reducing blood suger：18 portions of balsam pears, 13 parts of mulberry leaf, 6.8 parts of pueraria lobatas, 9.9 parts of L-arabinoses；
Conditioning composition：5 parts of mulberries, 9 parts of Radix Astragalis, 7 parts of Poria cocos, 9 parts of sealworts, 8 parts of ginsengs, 8 parts of Cordyceps militaris；
Toxin expelling composition：6.3 parts of corn stigmas.
2, it is described for adjusting, the preparation method is the same as that of Example 1 for the herbal cuisine composition of auxiliary hyperglycemic.
1 zoopery of experimental example
1, experimental animal
Purebred health adult male rabbit, weight 2.0kg or so, 40.
2, modeling and administration
By adult male rabbit 64,8 groups are randomly divided into, experimental group 1- experimental groups 6 correspond to corresponding embodiment 1- embodiments 6 respectively,
Remaining two groups are respectively model control group and blank control group, every group 8.Experimental group 1-6 and the high sugar of model control group feeding are high
Fat feed (10% lard, 37% white sucrose mix 53% basal feed), blank control group is fed with normal diet.
It is converted according to equivalent dose between animals and human beings, the rabbit of experimental group 1~6 takes orally 0.5g/kg daily.And it is above-mentioned each
Group divides equally 2 morning, gavages in afternoon, continuous gavage 1 month.Model control group and blank control group take orally the distillation of same volume
Water.
3, observation index
1. experimental animal is continuously fed 2 months, empty stomach 12h, each administration group according to dosage (give oral drugs respectively by each experimental group
With in embodiment 1-6 for adjusting, the herbal cuisine composition of auxiliary hyperglycemic) afterwards 2h start sugar tolerance detection, take orally sugarcane respectively
Sugar (pressing 4.2g/kg dosage) 0,0.5,2h survey rabbit auricular vein blood glucose value, using strong blood sugar monitoring instrument and test strips, through tail vein
Blood is taken to survey fasting blood sugar.It the results are shown in Table 2.It is handled using SPSS16.0 statistical softwares.Each index determining result is tested with Mean
Scholar SD is indicated.Mean compares using one-way analysis of variance and paired t-test, P between group<0.05 is statistically significant.
2. after experimental animal is continuously fed 2 months, administration group, which is according to dosage given (by 4.2g/kg dosage), to be administered orally (respectively
Experimental group give respectively in embodiment 1-6 for adjust, the herbal cuisine composition of auxiliary hyperglycemic).Before experiment, modeling
Each group rabbit weight is weighed when afterwards and administration intervenes 1 month, the results are shown in Table 3.
4, result and analysis
Influence (x ± s, mmol/L) of 4.1 oral drugs to rabbit fasting blood-glucose, such as table 2, P<0.05 has statistics meaning
Justice.
Table 2
| 0h | 0.5h | 2h | |
| Embodiment 1 | 6.86±0.26 | 6.24±0.21 | 3.85±0.18 |
| Embodiment 2 | 6.82±0.28 | 6.62±0.16 | 3.81±0.26 |
| Embodiment 3 | 6.84±0.26 | 6.58±0.28 | 4.28±0.21 |
| Embodiment 4 | 6.76±0.31 | 6.65±0.26 | 4.25±0.36 |
| Embodiment 5 | 6.78±0.25 | 6.61±0.23 | 4.38±0.32 |
| Embodiment 6 | 6.81±0.28 | 6.56±0.22 | 4.21±0.22 |
| Model control group | 6.81±0.33 | 6.24±0.31 | 7.91±0.32 |
| Blank control group | 5.87±0.28 | 6.16±0.33 | 5.92±0.36 |
It can be obtained according to table 2：After embodiment 1-6, model control group and the corresponding rabbit fasting blood-glucose 0.5h of blank control group
Difference is little, and after 2h, compared to model control group and blank control group, the corresponding rabbit fasting blood-glucoses of embodiment 1-6 are apparent
Hypoglycemic degree is big.Illustrate that the present embodiment 1-6 blood sugar reducing functions are notable.
4.2 be influence (x ± s, kg) of the oral drugs to rabbit weight, such as table 3, P<0.05 is statistically significant.
Table 3
| Initial weight | After modeling | After intervention | |
| Embodiment 1 | 2.01±0.14 | 3.14±0.21 | 3.25±0.28 |
| Embodiment 2 | 2.02±0.12 | 3.02±0.16 | 3.21±0.26 |
| Embodiment 3 | 2.00±0.15 | 2.88±0.18 | 3.28±0.31 |
| Embodiment 4 | 2.03±0.21 | 3.15±0.16 | 3.25±0.36 |
| Embodiment 5 | 1.99±0.15 | 3.11±0.13 | 3.38±0.32 |
| Embodiment 6 | 1.98±0.18 | 3.16±0.22 | 3.24±0.22 |
| Model control group | 2.01±0.16 | 3.14±0.19 | 3.98±0.22 |
| Blank control group | 2.02±0.18 | 2.56±0.13 | 2.92±0.26 |
It can be obtained according to table 3：The corresponding rabbit drugs of embodiment 1-6 are respectively after modeling compared with after pharmaceutical intervention, weight differences
Smaller, compared to model control group, the weight of the corresponding rabbits of embodiment 1-6 decreases, but the degree reduced is not very big.
2 clinical test of test example
1, case is selected
Patient totally 300 is chosen, is randomly divided into 6 groups, respectively corresponding embodiment 1-6, every group each 50.Above-mentioned all trouble
The equal ＞ 7.2mmol/L of person's fasting blood sugar amount FPG, and ＜ 14.9mmol/L.The course of disease of above-mentioned patient between 8 months~3 years,
And hypoglycemic drug is not taken in the recent period.Each group patient is equal in age, gender, the state of an illness, the course of disease, symptom and weight etc.
Difference (p ＞ 0.05) without conspicuousness, therefore be comparable.
2, dosage
It is of the present invention for adjust, the instructions of taking of the herbal cuisine composition of auxiliary hyperglycemic is：Adult each taking
10-15g, daily 1-3 times；Dose also can suitably be adjusted according to weight and conditions of patients.Continuous 2-3 months.
3, the standard of curative effect evaluation
It is formulated according to the relevant criterion of therapeutical effect of World Health Organization's diabetes as follows：
(1) effective：Fasting blood-glucose (FPG) ＜ 6.6mmol/L, oral glucose tolerance test 2h blood glucose levels (2h PBG) ＜
8.2mmol/L, associated clinical symptoms disappear substantially.
(2) effectively：Fasting blood-glucose (FPG) ＜ 8.5mmol/L, oral glucose tolerance test 2h blood glucose levels (2h PBG) ＜
10.8mmol/L, clinical symptoms are obviously improved.
(3) invalid：Fasting blood-glucose (FPG) ＞ 8.5mmol/L, oral glucose tolerance test 2h blood glucose levels (2h PBG) ＞
10.8mmol/L, clinical symptoms do not change significantly, and the results are shown in Table 4.
4, result and analysis
4 clinical efficacy of table
| It is effective | Effectively | In vain | Total effective rate | |
| Embodiment 1 | 47 | 2 | 1 | 94% |
| Embodiment 2 | 48 | 1 | 1 | 98% |
| Embodiment 3 | 45 | 1 | 4 | 92% |
| Embodiment 4 | 44 | 0 | 6 | 88% |
| Embodiment 5 | 44 | 1 | 6 | 90% |
| Embodiment 6 | 45 | 0 | 5 | 90% |
It can be obtained according to table 4, the herbal cuisine provided by the invention for treating diabetes total effective rate in treatment diabetes is up to
To 98%, while after above-mentioned patient drug withdrawal, blood glucose can maintain essentially in normal level.
In conclusion provided by the present invention for adjusting, the herbal cuisine composition of auxiliary hyperglycemic, the main work(of compound for reducing blood suger
Effect be it is hypoglycemic, wherein each group subassembly number of ways carry out it is hypoglycemic；Conditioning composition, nourishing liver and kidney the moon are enriched blood
Gas, improves immunity at many-sided adjusting body, is tool to human body if conditioning composition and compound for reducing blood suger are effectively combined
There is good tonic effect, not only improves the function of reducing blood sugar of compound for reducing blood suger, moreover it is possible to improve the immunity of the human body；The toxin expelling combination
Corn stigma in object has effects that diuresis hypoglycemic claps poison；If finding that the dosage of each component is crossed conference and caused by research
It is be easy to cause hypoglycemia, blood pressure is increased, influences the problems such as absorption of the human body to plant composition, if dosage is too small and can make to match
Dietotherapy effect that side loses attribute balance, temperature compensation effect is not achieved and can also weaken plant composition, just creatively proposes this
Invention for adjusting, the dosage of each component in the herbal cuisine composition of auxiliary hyperglycemic, the selection collocation of this dosage makes treatment
The herbal cuisine herbal compositions of diabetes can have stabilizing blood sugar to diabetic, reduce the double of blood glucose with long-term drinking
Weight food therapy effect, can effectively prevent diabetic syndrome, have professional and scientific, each component compounding synergy, each group
The rational compounding divided, can greatly improve the cure rate of diabetes, up to 98% or more.
Model case is enumerated
Some typical cases are chosen in this part, and patient is mainly the middle-aged and the old, also there is small part young man.Due to usual
In the case of type 1 diabetes age of onset it is light, mostly<It 30 years old, is applied alone oral medicine invalid, insulin therapy need to be used.And the present invention
Another big feature be in clinical test case, find the present invention for adjust, the herbal cuisine composition of auxiliary hyperglycemic not only
It can be used for treating diabetes B, and significant effect；Treatment type 1 diabetes are can be also used for, and with preferably effect.Sugar
The sick complication of urine is numerous, can be divided into acute complications and chronic complicating diseases.Acute complications include mainly in Diabetic ketosis acid
Poison and the hypertonic nonketotic coma of diabetes (being more common in diabetes B)；Chronic complicating diseases accumulate each histoorgan of whole body, mainly
Including big blood vessel (such as angiocarpy, the cerebrovascular, Renal vascular and the big blood vessel of four limbs), (such as diabetic nephropathy and diabetes regard capilary
Retinopathy) and neuropathy (such as autonomic nerve and somatic nerves) etc..
(1) model case 1
Zhao so-and-so, man, 26 years old, company's white collar, type-1 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, it is thirsty, it is more drink, it is more
Urine, more food and it is weak become thin, the symptoms such as weight drastically declines are fairly obvious.The combination of the offer of embodiment 1 is provided from 2015
Object, three times per day, a 15g, 30 minutes before meals oral.After 3 months, blood glucose is normal, takes secondary a, 10g daily later,
30 minutes before meals oral, and blood glucose is normal so far, and more foods, diuresis, weak symptom are obviously improved.
(2) model case 2
Wu so-and-so, man, 25 years old, millworker, type-1 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, it is thirsty, it is more drink, it is more
Urine, more foods and weak, weight loss, there is ketoacidosis when starting, the combination of the offer of embodiment 1 is taken from 2015
Object, three times per day, a 15g, 30 minutes before meals oral.After 3 months, blood glucose is normal, takes secondary a, 10g daily later,
30 minutes before meals oral, and blood glucose is normal so far, and more foods, diuresis, weak symptom are obviously improved.
(3) model case 3
Chen, female, 65 years old, retired worker, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, hand often occur
Foot is ice-cold, weakness of limbs, the inability that can feel hungry suddenly, shake, dizzy, heartbeat quickly, body largely emit cold sweat always.2015
Year acts the composition for taking the offer of embodiment 1, and two times a day, a 10g, 30 minutes before meals oral.After 2 months, blood glucose is normal,
Take secondary a, 5g daily later, 30 minutes before meals oral, and blood glucose is normal so far, hunger, weak sense and dizziness
It is substantially reduced.
(4) model case 4
It is bright so-and-so, female, 60 years old, retired worker, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, often occurred hungry
Starve sense, constipation, pruitus, fatiguability.The composition of the offer of embodiment 1 is taken from 2015, two times a day, once
10g, 30 minutes before meals oral.After 2 months, blood glucose is normal, takes secondary a, 5g daily later, and 30 minutes before meals are oral, until
Modern blood glucose is normal, and hunger, constipation phenomenon and skin itching symptom are substantially reduced.
(5) model case 5
Slowly so-and-so, female, 55 years old, high school teachers, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, and diuresis, skin are dry
Dry, thirsty, faint, breathing is slow and very deep, Nausea and vomiting situation.The combination of the offer of embodiment 1 is provided from 2015
Object, three times per day, a 15g, 30 minutes before meals oral.After 2 months, blood glucose is normal, takes secondary a, 10g daily later,
30 minutes before meals oral, and blood glucose is normal so far, and thirsty, faint symptom is obviously improved.
(6) model case 6
Mr. Wang, man, 66 years old, retired worker, type-2 diabetes mellitus, suffer from hyperglycemia, dysuria, visual impairment, often
It is dizzy.The composition of the offer of embodiment 1 is taken from 2015, two times a day, a 15g, 30 minutes before meals oral.After 2 months,
Blood glucose is normal, takes secondary a, 5g daily later, and 30 minutes before meals oral, and blood glucose is normal so far, dysuria and giddy disease
Shape is obviously improved.
(7) model case 7
Mr. Li, female, 62 years old, peasant, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, pruitus, made one difficult
To fall asleep, especially female private part itch is even more serious, dizzy sometimes, and the composition of the offer of embodiment 1 is taken from 2015,
Two times a day, a 10g, 30 minutes before meals oral.After 2 months, blood glucose is normal, takes secondary a, 5g daily later, before meals
30 minutes oral, and blood glucose is normal so far, skin itching symptom hardly occurs.
(8) model case 8
River so-and-so, female, 67 years old, retired worker, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, often occurred hungry
Sense is starved, weak palpitaition numb in every limb, pain and burn feeling etc. occurs, will produce the feeling for such as stepping on cotton on foot sometimes.2015
Year acts the composition for taking the offer of embodiment 1, and two times a day, a 10g, 30 minutes before meals oral.After 2 months, blood glucose is normal,
Take secondary a, 5g daily later, 30 minutes before meals oral, and blood glucose is normal so far, and hunger and brothers' feeling of pain obviously subtract
Gently.
(9) model case 9
Zhang, man, 65 years old, retired worker, type-2 diabetes mellitus, preprandial glucose and postprandial blood sugar were high, often can be dizzy,
Hand and foot numbness is shaken, and crural paralysis, pain in the back are not desired to walk.The composition of the offer of embodiment 1 is provided from 2015, three times per day,
15g, 30 minutes before meals oral.After 2 months, blood glucose is normal, takes secondary a, 5g daily later, before meals 30 minutes mouths
Clothes, blood glucose is normal so far, and hand and foot numbness symptom of shaking substantially improves.
(10) model case 10
Mr. Li, female, 68 years old, retired worker, type-2 diabetes mellitus, preprandial glucose was high, obstinate diarrhea and constipation occurs,
Often dizzy, the composition of the offer of embodiment 1 is taken from 2015, two times a day, a 10g, 30 minutes before meals are oral.2
After month, blood glucose is normal, takes secondary a, 5g daily later, and 30 minutes before meals are oral, and blood glucose is normal so far, almost without it is dizzy,
Constipation and symptom of diarrhea.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (9)
1. it is a kind of for adjust, the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that its material composition include hypoglycemic combination
Object, conditioning composition and toxin expelling composition, each component account for the proportion in total raw material, and the compound for reducing blood suger is 40%-60%, is adjusted
Reason composition is 30%-50%, and toxin expelling composition is 1%-20%；
Wherein, the compound for reducing blood suger includes balsam pear, mulberry leaf, pueraria lobata and L-arabinose, and balsam pear：(mulberry leaf+pueraria lobata)：L- Ah
Draw uncle sugar=2：2.2：1.1；
The conditioning composition includes mulberry fruit, Radix Astragali, ginseng, Poria cocos, sealwort, and mulberry fruit：(Radix Astragali+Poria cocos+sealwort)：Ginseng=
1：5：1.6；
The toxin expelling composition includes corn stigma.
2. being used to adjust as described in claim 1, the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that the hypoglycemic group
The each component closed in object accounts for the proportion in total raw material, balsam pear 18-22%, mulberry leaf 13-17%, pueraria lobata 5-9%, L- I
Uncle's sugar is 9-13%.
3. being used to adjust as described in claim 1, the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that the conditioning group
It further includes Cordyceps militaris to close in object, and mulberry fruit：(Radix Astragali+Poria cocos+sealwort)：(ginseng+Cordyceps militaris)=1：5：3.2.
4. being used to adjust as claimed in claim 3, the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that the conditioning group
The each component closed in object accounts for the proportion in total raw material, mulberry fruit 4-7%, Radix Astragali 8-12%, Poria cocos 3-7%, sealwort 8-
12%, ginseng 6-10%, Cordyceps militaris 6-10%.
5. being used to adjust as described in claim 1, the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that the corn stigma
The proportion accounted in total raw material is 1-20%.
6. it is a kind of it is according to any one of claims 1 to 5 for adjust, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic,
It is characterized in that, includes the following steps：
Step 1, the raw material for weighing the number as described in claim 1-5, in addition to mulberry leaf, corn stigma and L-arabinose, other are former
Expect that mixing is added in culture medium, access strain, ferment 20-30 days at normal temperatures, repeat fermentation three times, obtains herb fermenting object；
Step 2 mixes mulberry leaf with corn stigma, after adding water to cook, is extracted with water, and obtains Chinese medical extract；
Step 3, the Chinese medicine extract for taking step (2) to prepare and to mixing in Chinese medicine fermented liquid in step (1) carry out it is homogeneous after,
L-arabinose is added and forms Chinese medicine composition；
Step 4 sterilizes after the Chinese medicine composition of gained in step 3 is packed or bottled.
7. being used to adjust as claimed in claim 6, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that
In the step 1,2 × 10 are pressed in the fermentation medium7The inoculum concentration of cfu/mL accesses strain.
8. being used to adjust as claimed in claim 6, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that
In the step 2, after being extracted with water, the upper macroporous resin column of extracting solution concentration is eluted with water to sample discharge and reduces, then uses
95% ethanol elution collects eluent and carries out that acquisition Chinese medical extract is concentrated under reduced pressure.
9. being used to adjust as claimed in claim 6, the preparation method of the herbal cuisine composition of auxiliary hyperglycemic, which is characterized in that
In the step 4, the sterilizing is ozone sterilization or high-temperature sterilization.
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| CN111728214A (en) * | 2020-08-13 | 2020-10-02 | 珠海市天顺保健食品有限公司 | Medicinal and edible composition for assisting in reversing diabetes |
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| CN110367422A (en) * | 2019-09-08 | 2019-10-25 | 李丽 | A kind of rhizoma polygonati mulberry leaf compound solid beverage and preparation method thereof |
| CN111728214A (en) * | 2020-08-13 | 2020-10-02 | 珠海市天顺保健食品有限公司 | Medicinal and edible composition for assisting in reversing diabetes |
| CN113521186A (en) * | 2021-07-24 | 2021-10-22 | 陕西秦岭七药协同创新中心有限公司 | Hypoglycemic drug and preparation method and application thereof |
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Application publication date: 20180824 |