CN108434002A - A kind of anti-oxidant serum microcapsules and preparation method thereof - Google Patents
A kind of anti-oxidant serum microcapsules and preparation method thereof Download PDFInfo
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- CN108434002A CN108434002A CN201810530344.1A CN201810530344A CN108434002A CN 108434002 A CN108434002 A CN 108434002A CN 201810530344 A CN201810530344 A CN 201810530344A CN 108434002 A CN108434002 A CN 108434002A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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Abstract
The invention discloses a kind of anti-oxidant serum microcapsules and preparation method thereof, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 1~2:1, a diameter of 1~5mm of microcapsules；By weight, the anti-oxidant serum includes：12~25 parts of astaxanthin, 11~21 parts of tocopherol, 8~16 parts of tocopheryl succinate, 3~11 parts of ascorbyl stearate, 1~8 part of ascorbyl palmitate, 2~8 parts of Jojoba Oil, 2~8 parts of retinol, 1~7 part of propionic acid retinol ester, 1~6 part of glycerine, 2~6 parts of D-sorbite.(1) such environmental effects such as anti-oxidant serum microcapsules light of the present invention, heat are small, are not easily decomposed, and property is stablized；(2) anti-oxidant serum microcapsule granule of the present invention is regular spherical shape, and wall thickness is uniform, has stable intensity and elasticity, it is ensured that capsule-core embeds effect.
Description
Technical field
The invention belongs to cosmetic technical fields, are related to a kind of anti-oxidant serum, specially a kind of anti-oxidant serum
Microcapsules and preparation method thereof.
Background technology
Human senility or aging are the inexorable laws in biological life growth course, are the physiology mistakes of a generally existing
Journey.Internationally recognized aging theory is free-radical theory can prove to cause aging by a large amount of in vitro and in vivo experiments
The key reason that degeneration changes in journey, is the free radical generated in cell normal metabolic processes.Free radical is eubolism
Intermediate product, respond is very strong, and many kinds of substance in cell can be made to aoxidize, and damages biomembrane, and then make skin
Structure and hypofunction, adaptability and resistance decline.And for most of people seeking beauties, possessing perfect skin is
The pursuit in all one's life, on the basis of having realized that skin aging true cause, people begin to use effective anti-aging to make up
Product remove delaying skin aging.
Existing anti-aging substance, general properties are unstable, are easily illuminated by the light, the influence of the environmental factors such as temperature, if will
These anti-aging substances are not added with protection, are directly appended in cosmetics, it is easy to by photodegradation；And the distinctive pH value of cosmetics,
Also certain negative effect can be caused to these anti-aging substances.
Microcapsules technology is exactly by micro solid, liquid or gas entrapment, seals up for safekeeping in thin polymer film, becomes a kind of
The technology of solia particle product.Microcapsules technology can significantly protect the stability of capsule-core substance, prevent between various components
It interferes with each other.Hydrogel microcapsule, for main cyst material, has good embedding rate, and outside hydrogel microcapsule with hydrogel
Table is translucent, increases the aesthetics of microcapsules, has splendid visual effect.If with hydrogel microcapsule skill
Anti-aging substance is embedded in effect microcapsule wall by art, reduces the harmful effects of the factors to anti-aging substance such as light, heat, will
Obtain good stablizing effect and aesthetics.
Invention content
Present invention solves the technical problem that：In order to overcome the deficiencies of existing technologies, a kind of good anti-oxidant of stability is obtained
Essence, the present invention provides a kind of anti-oxidant serum microcapsules and preparation method thereof.
Technical solution：A kind of anti-oxidant serum microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid,
In, cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 1~2:1, microcapsules
A diameter of 1~5mm；By weight, the anti-oxidant serum includes：12~25 parts of astaxanthin, 11~21 parts of tocopherol, amber
8~16 parts of amber acid tocopherol, 3~11 parts of ascorbyl stearate, 1~8 part of ascorbyl palmitate, Jojoba Oil 2~8
Part, 2~8 parts of retinol, 1~7 part of propionic acid retinol ester, 1~6 part of glycerine, 2~6 parts of D-sorbite.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For anti-oxidant serum, the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 1mm of microcapsules；By weight, the antioxygen
Changing essence includes：12 parts of astaxanthin, 11 parts of tocopherol, 8 parts of tocopheryl succinate, 3 parts of ascorbyl stearate, Vitamin C
1 part of sour palmitate, 2 parts of Jojoba Oil, 2 parts of retinol, 1 part of propionic acid retinol ester, 1 part of glycerine, 2 parts of D-sorbite.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For anti-oxidant serum, the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 3mm of microcapsules；By weight, the antioxygen
Changing essence includes：It is 20 parts of astaxanthin, 16 parts of tocopherol, 12 parts of tocopheryl succinate, 7 parts of ascorbyl stearate, anti-bad
4 parts of hematic acid palmitate, 4 parts of Jojoba Oil, 5 parts of retinol, 3 parts of propionic acid retinol ester, 3 parts of glycerine, 4 parts of D-sorbite.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For anti-oxidant serum, the mass ratio of cyst wall and capsule-core is 2:1, a diameter of 5mm of microcapsules；By weight, the antioxygen
Changing essence includes：It is 25 parts of astaxanthin, 21 parts of tocopherol, 16 parts of tocopheryl succinate, 11 parts of ascorbyl stearate, anti-bad
8 parts of hematic acid palmitate, 8 parts of Jojoba Oil, 8 parts of retinol, 7 parts of propionic acid retinol ester, 6 parts of glycerine, 6 parts of D-sorbite.
The preparation method of any description above anti-oxidant serum microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion Han 220~260mmol/L adjusts pH to 6~7, after lasting stirring
It is placed in 28~37 DEG C of insulating box and reacts；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 28~37 DEG C of insulating box, reacts 4~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
Preferably, the mass percent concentration of sericin solution is 2~8%.
Preferably, the metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
Preferably, the molecular weight of the sericin is 10000~80000Da.
Advantageous effect：(1) such environmental effects such as anti-oxidant serum microcapsules light of the present invention, heat are small, are not easy
It decomposes, property is stablized；(2) anti-oxidant serum microcapsule granule of the present invention is regular spherical shape, and wall thickness is uniform, tool
There are stable intensity and elasticity, it is ensured that capsule-core embeds effect；(3) the microcapsule embedded effect of anti-oxidant serum of the present invention
Good, embedding rate effectively keeps apart active constituent and extraneous oxygen, dust etc. up to 95% or more.
Specific implementation mode
Embodiment 1
A kind of anti-oxidant serum microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is silk
Glue protein shell membrane, capsule-core are anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 1mm of microcapsules；By weight
Part meter is measured, the anti-oxidant serum includes：12 parts of astaxanthin, 11 parts of tocopherol, 8 parts of tocopheryl succinate, ascorbic acid are hard
3 parts of resin acid ester, 1 part of ascorbyl palmitate, 2 parts of Jojoba Oil, 2 parts of retinol, 1 part of propionic acid retinol ester, 1 part of glycerine,
2 parts of D-sorbite.
The preparation method of the anti-oxidant serum microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 220mmol/L, adjusts pH to 6, and lasting stirring is placed on 28 DEG C
Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 28 DEG C of insulating box, reacts 4 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 2%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 2
A kind of anti-oxidant serum microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is silk
Glue protein shell membrane, capsule-core are anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 3mm of microcapsules；By weight
Part meter is measured, the anti-oxidant serum includes：20 parts of astaxanthin, 16 parts of tocopherol, 12 parts of tocopheryl succinate, ascorbic acid are hard
7 parts of resin acid ester, 4 parts of ascorbyl palmitate, 4 parts of Jojoba Oil, 5 parts of retinol, 3 parts of propionic acid retinol ester, 3 parts of glycerine,
4 parts of D-sorbite.
The preparation method of the anti-oxidant serum microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 240mmol/L, adjusts pH to 6.5, and lasting stirring is placed on 32
DEG C insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 32 DEG C of insulating box, reacts 8 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 4%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 3
A kind of anti-oxidant serum microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is silk
Glue protein shell membrane, capsule-core are anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 2:1, a diameter of 5mm of microcapsules；By weight
Part meter is measured, the anti-oxidant serum includes：25 parts of astaxanthin, 21 parts of tocopherol, 16 parts of tocopheryl succinate, ascorbic acid are hard
11 parts of resin acid ester, 8 parts of ascorbyl palmitate, 8 parts of Jojoba Oil, 8 parts of retinol, 7 parts of propionic acid retinol ester, 6 parts of glycerine,
6 parts of D-sorbite.
The preparation method of the anti-oxidant serum microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 260mmol/L, adjusts pH to 7, and lasting stirring is placed on 37 DEG C
Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 37 DEG C of insulating box, reacts 12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 8%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
The anti-oxidant serum microcapsules that Examples 1 to 3 prepares are detected, the results are shown in table below：
Claims (8)
1. a kind of anti-oxidant serum microcapsules, which is characterized in that microcapsules are the transparent sphere soft capsule of nucleocapsid,
In, cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, and the mass ratio of cyst wall and capsule-core is 1~2:1, microcapsules
A diameter of 1~5mm；By weight, the anti-oxidant serum includes：12~25 parts of astaxanthin, 11~21 parts of tocopherol, amber
8~16 parts of amber acid tocopherol, 3~11 parts of ascorbyl stearate, 1~8 part of ascorbyl palmitate, Jojoba Oil 2~8
Part, 2~8 parts of retinol, 1~7 part of propionic acid retinol ester, 1~6 part of glycerine, 2~6 parts of D-sorbite.
2. a kind of anti-oxidant serum microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid
Transparent sphere soft capsule, wherein cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, the mass ratio of cyst wall and capsule-core
It is 1:1, a diameter of 1mm of microcapsules；By weight, the anti-oxidant serum includes：12 parts of astaxanthin, tocopherol 11
Part, 8 parts of tocopheryl succinate, 3 parts of ascorbyl stearate, 1 part of ascorbyl palmitate, 2 parts of Jojoba Oil, retinol
2 parts, 1 part of propionic acid retinol ester, 1 part of glycerine, 2 parts of D-sorbite.
3. a kind of anti-oxidant serum microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid
Transparent sphere soft capsule, wherein cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, the mass ratio of cyst wall and capsule-core
It is 1:1, a diameter of 3mm of microcapsules；By weight, the anti-oxidant serum includes：20 parts of astaxanthin, tocopherol 16
Part, regards Huang at 12 parts of tocopheryl succinate, 7 parts of ascorbyl stearate, 4 parts of ascorbyl palmitate, 4 parts of Jojoba Oil
5 parts of alcohol, 3 parts of propionic acid retinol ester, 3 parts of glycerine, 4 parts of D-sorbite.
4. a kind of anti-oxidant serum microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid
Transparent sphere soft capsule, wherein cyst wall is sericin shell membrane, and capsule-core is anti-oxidant serum, the mass ratio of cyst wall and capsule-core
It is 2:1, a diameter of 5mm of microcapsules；By weight, the anti-oxidant serum includes：25 parts of astaxanthin, tocopherol 21
Part, regards Huang at 16 parts of tocopheryl succinate, 11 parts of ascorbyl stearate, 8 parts of ascorbyl palmitate, 8 parts of Jojoba Oil
8 parts of alcohol, 7 parts of propionic acid retinol ester, 6 parts of glycerine, 6 parts of D-sorbite.
5. the preparation method of any anti-oxidant serum microcapsules of Claims 1 to 4, which is characterized in that the method packet
Include following steps：
(1) the sericin solution for preparing the metal ion Han 220~260mmol/L, adjusts pH to 6~7, and lasting stirring is placed on
It is reacted in 28~37 DEG C of insulating box；
(2) solution after reacting step (1) centrifuges precipitation, is washed with deionized and removes extra metal ion, so
The each component of capsule-core is added afterwards, lasting stirring, which is placed in 28~37 DEG C of insulating box, reacts 4~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
6. the preparation method of anti-oxidant serum microcapsules according to claim 5, which is characterized in that sericin solution
Mass percent concentration be 2~8%.
7. the preparation method of anti-oxidant serum microcapsules according to claim 5, which is characterized in that the metal ion
For any one in calcium ion, magnesium ion, copper ion, zinc ion.
8. the preparation method of anti-oxidant serum microcapsules according to claim 5, which is characterized in that the sericin
Molecular weight be 10000~80000Da.
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| CN201810530344.1A CN108434002A (en) | 2018-05-29 | 2018-05-29 | A kind of anti-oxidant serum microcapsules and preparation method thereof |
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| CN201810530344.1A CN108434002A (en) | 2018-05-29 | 2018-05-29 | A kind of anti-oxidant serum microcapsules and preparation method thereof |
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| CN108434002A true CN108434002A (en) | 2018-08-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440467A (en) * | 2021-06-02 | 2021-09-28 | 东阿阿胶股份有限公司 | Repairing and moistening hydrogel microcapsule containing donkey-hide gelatin as well as preparation method and application of repairing and moistening hydrogel microcapsule |
-
2018
- 2018-05-29 CN CN201810530344.1A patent/CN108434002A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440467A (en) * | 2021-06-02 | 2021-09-28 | 东阿阿胶股份有限公司 | Repairing and moistening hydrogel microcapsule containing donkey-hide gelatin as well as preparation method and application of repairing and moistening hydrogel microcapsule |
| CN113440467B (en) * | 2021-06-02 | 2022-07-05 | 东阿阿胶股份有限公司 | Repairing and moistening hydrogel microcapsule containing donkey-hide gelatin as well as preparation method and application of repairing and moistening hydrogel microcapsule |
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Application publication date: 20180824 |