CN108420464B - Biopsy sampling device - Google Patents
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- CN108420464B CN108420464B CN201810254540.0A CN201810254540A CN108420464B CN 108420464 B CN108420464 B CN 108420464B CN 201810254540 A CN201810254540 A CN 201810254540A CN 108420464 B CN108420464 B CN 108420464B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
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- Engineering & Computer Science (AREA)
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- Surgical Instruments (AREA)
Abstract
The invention discloses a biopsy sampling device. The biopsy sampling device is particularly suitable for biopsy sampling of small-volume tumors such as bone and soft tissue tumors and/or tissues adjacent to important blood vessels, nerves and the like around the tumors, and can solve the problems of small puncture operation space range and biopsy requiring accurate positioning. Wherein the guide needle can be connected with the injector through the needle seat to perform local anesthesia and perspective positioning work, so that the operation steps of the operation can be reduced, and the pain of a patient can be relieved; and because the guide needle only plays a role in guiding or injecting, the diameter can be very small, thereby the operable space around the tumor can be increased, the operation difficulty of repeated puncture can be reduced, the damage to tissues can be reduced, and under the guidance of the needle head tube, the outer sleeve and the sampling inner core can effectively avoid peripheral important tissue organs when being inserted into the body, and the risk of puncture can be reduced. The biopsy sampling device combines minimally invasive guidance and anesthesia guidance, which is beneficial to shortening the operation process.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a biopsy sampling device.
Background
Bone and soft tissue tumors play an important role in orthopedics, and diagnosis and treatment of which have been a difficult problem in orthopedics. Clinically, bone tissue biopsy is an important means for diagnosing various bone diseases, and a biopsy needle is an instrument necessary in the bone tissue biopsy process, but the currently applied biopsy needle can only meet the requirements of clinical routine bone tissue puncture, and is difficult to meet the use requirements of special occasions, such as biopsy sampling occasions of some bone and soft tissue tumors.
Some bone and soft tissue tumors are small in size (the maximum diameter of the tumor is only 2-5 cm) and difficult to locate, and tissue organs such as important blood vessels, nerves and spinal cords are often adjacent to the periphery of the tumor tissues, and even if the related imaging navigation assistance is used, repeated puncture is needed due to limited operable space around the tumor. The traditional bone tissue puncture needle has the specification of 8-15G (the inner diameter is larger than 1.3 mm), repeated puncture is easy to cause the operation time to be prolonged, and the peripheral tissue injury can cause unnecessary pain to a patient, and the medical complications such as peripheral vascular injury, nerve injury, spinal cord injury and the like can be caused when the injury is serious.
There are also some improved biopsy needles in the traditional art, such as improvement on the problem that bone and soft tissue tumors are difficult to take out, and improvement on the positioning problem during biopsy, etc., but the traditional biopsy needle still has the problems of low positioning accuracy of puncture and easy tissue damage.
Disclosure of Invention
Accordingly, it is desirable to provide a biopsy sampling device that can improve positioning accuracy and reduce tissue damage problems.
A biopsy sampling device, comprising:
The guide needle comprises a needle seat and a needle head pipe connected with the needle seat, the needle seat and the needle head pipe can be separated, and the needle head pipe is used for puncturing to a target tissue part;
the outer sleeve comprises an outer sleeve fixing part and a cutting sleeve part, the outer sleeve fixing part is connected to one end of the cutting sleeve part, the outer sleeve fixing part is used for being left outside the body, the other end of the cutting sleeve part is provided with a cutting head, and the cutting sleeve part can be sleeved on the needle head pipe and can be cut into the target tissue part along the needle head pipe through the cutting head; and
The sampling inner core comprises a sampling fixing part and a sampling sleeve part, the sampling fixing part is connected to one end of the sampling sleeve part, the sampling fixing part can be in limit fit with the outer sleeve fixing part, the other end of the sampling sleeve part is provided with a sampling head, and the sampling sleeve part is used for being inserted into the cutting sleeve part and can be inserted into a sampling part along the cutting sleeve part and/or the needle head pipe;
The length of the needle tube is longer than that of the outer sleeve.
In one embodiment, the needle cannula has an inner diameter of 0.06mm to 0.16mm.
In one embodiment, the length of the needle cannula is greater than the length of the sampling core and the length of the sampling cannula portion is greater than the length of the cutting cannula portion.
In one embodiment, the needle seat is provided with an annular, single-wing or double-wing pintle.
In one embodiment, the needle hub is connected with the needle tube through a threaded connecting tube, an inserted sleeve tube, a pre-broken connecting tube or a shearable connecting tube.
In one embodiment, the sampling core further comprises a handle portion, the handle portion being connected to the sampling fixation portion.
In one embodiment, the outer sleeve fixing portion is provided with a stepped limiting hole communicated with the cutting sleeve portion, and the sampling fixing portion is of an annular stepped structure matched with the limiting hole.
In one embodiment, the cutting head has a sharp edge ring formed by a plurality of semicircular cutting edges in a ring or a plurality of cutting edges arranged in a worm shape;
The sampling head is in the shape of an inclined tip, a strip-shaped head, a polygonal prism-shaped tip, a hook-shaped tip or a worm-shaped tip.
In one embodiment, the needle cannula, the cutting cannula portion and the sampling cannula portion are provided with graduation marks.
In one embodiment, the biopsy sampling device further comprises a needle fixing device, the needle fixing device comprises a cross beam, needle locking screws, supporting rods, supporting casters and caster locking screws, the cross beam is provided with fixing holes through which needle tubes can pass, one ends of the needle locking screws can be screwed into the fixing holes to be in contact with the needle tubes so as to fix the needle tubes in the fixing holes in a locking mode, tooth openings are formed in two sides of the fixing holes respectively of the cross beam, the two supporting rods are two, the supporting rods can respectively pass through the two tooth openings to be meshed with the cross beam, the distance between the two supporting rods is adjustable, the supporting casters are oval, one sides of the supporting casters are provided with rubber surfaces, the supporting casters are arranged at two ends of the supporting rods, and the caster locking screws are used for locking and fixing the supporting casters at the end portions of the supporting rods.
The biopsy sampling device is particularly suitable for biopsy sampling of small-volume tumors such as bone and soft tissue tumors and/or tissues adjacent to important blood vessels, nerves and the like around the tumors, and can solve the problems of small puncture operation space range and biopsy requiring accurate positioning. In general, the biopsy sampling device of the present invention has at least the following advantages:
1. After the guide needle is inserted into the target tissue part, the guide needle can be connected with the injector through the needle seat to perform local anesthesia and perspective positioning work, other invasive anesthesia operations are not needed, operation steps can be reduced, and pain of a patient is relieved;
2. The guide needle only plays a role in guiding or injecting, so that the diameter is very small, the operable space around the tumor can be increased, the operation difficulty of repeated puncture is reduced, particularly when repeated positioning operation is needed, the diameter of the guide needle can be far smaller than that of a traditional bone tissue puncture needle, the pain of a patient in the operation process can be reduced, the damage to surrounding tissues is small, and the postoperative repair of the patient is facilitated;
3. The needle seat of the guide needle can be separated from the needle tube, so that after the needle seat is separated from the needle tube inserted into the target tissue part, the outer sleeve and/or the sampling inner core can be directly guided by the needle tube to directly reach the target tissue part for sampling, and under the guidance of the needle tube, the peripheral important tissue organs can be effectively avoided when the outer sleeve and the sampling inner core are inserted into the body, and the risk of puncture is reduced;
4. The biopsy sampling device integrates the advantages, is safe in sampling process and convenient to operate, can improve the success probability of biopsy on the whole, can finish puncture operation once, and avoids repeated puncture;
5. the biopsy sampling device combines minimally invasive guidance and anesthesia guidance, is beneficial to shortening the operation process and reducing the damage of radiation generated by perspective or CT positioning to patients and medical staff.
Drawings
FIG. 1 is a schematic view of a biopsy sampling device according to an embodiment of the present invention;
FIGS. 2a, 2b and 2c are schematic views of the structure of the guide needle of the annular pintle, the single-winged pintle and the double-winged pintle, respectively;
FIGS. 3a, 3b and 3c are schematic views showing the connection between the needle hub and the needle cannula through the pre-broken connection tube, the plug-in type connection tube and the threaded connection tube, respectively;
FIG. 4 is a schematic view of the outer sleeve of FIG. 1;
FIGS. 5a and 5b are front and side views, respectively, of a cutting head of an outer sleeve formed of a plurality of semicircular cutting edges in a ring, and FIG. 5c is a schematic structural view of a cutting head formed of a plurality of cutting edges arranged in a worm-gear shape;
FIG. 6 is a schematic view of the sampling core of FIG. 1;
FIGS. 7a, 7b, 7c, 7d and 7e are schematic structural views of a sampling head having an oblique tip shape, an elongated head shape, a polygonal column tip shape, a hook tip shape and a worm wheel tip shape of a sampling core, respectively;
FIG. 8 is a schematic view illustrating the cooperation between the guide pin and the outer sleeve of FIG. 1;
FIG. 9 is a schematic illustration of the mating of the outer sleeve of FIG. 1 with a sampling inner core;
FIG. 10 is a schematic view of the mating of the introducer needle, outer cannula and needle mount of FIG. 1;
FIGS. 11a, 11b, 11c and 11d are a top view, a schematic view of the support casters, a top view of the cross beam and a side view of the cross beam, respectively, of the needle mount of FIG. 10;
fig. 12 is a photograph of an image of a bone tumor volunteer in example 1.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
As shown in FIG. 1, one embodiment of a biopsy sampling device 10 includes an introducer needle 100, an outer cannula 200, and a sampling core 300. The introducer needle 100 is used primarily for drug injection and as a guide when the outer cannula 200 and/or the sampling core 300 are inserted. The outer cannula 200 is used in conjunction with the sampling core 300 to cut into a target tissue site for sampling.
Specifically, referring to fig. 2a, the guide needle 100 has a hollow structure including a needle holder 110 and a needle tube 120 connected to the needle holder 110. Hub 110 is separable from needle cannula 120, and needle cannula 120 is adapted to pierce to a target tissue site.
In the present embodiment, the needle holder 110 has a pintle 112a for mating with an external injection device such as a syringe. The pintle 112a of the introducer needle 100 shown in FIG. 2a is annular in shape. In other embodiments, the pintle 112b shown in FIG. 2b and the pintle 112c shown in FIG. 2c are single-winged and double-winged, respectively. Single-winged and double-winged needle pegs facilitate handling, such as insertion of introducer needle 100, attachment of a syringe, repeated penetration and detachment from needle cannula 120, while also being easily secured, and reduce patient deflection due to slight shock such as twitches (biopsy is typically local anesthesia). The pintle on the hub 110 is preferably a single-winged pintle.
The needle holder 110 and the needle tube 120 of the present embodiment are detachably connected. Specifically, as shown in fig. 3a, 3b and 3c, the hub 110 and the needle tube 120 may be connected by a pre-broken connection tube, a plug-in connection tube, a screw connection tube, or the like. Wherein, the pre-folded connecting pipe, namely the connecting pipe is provided with a pre-fold which is convenient to break; the plug-in ferrule, i.e., hub 110, may be inserted into needle cannula 120 or needle cannula 120 may be inserted into hub 110; the threaded connection tube, i.e., the hub 110, is in threaded connection with the needle cannula 120 at the end, for example, external threads may be provided on the hub 110, internal threads may be provided on the needle cannula 120, or internal threads may be provided on the hub 110, external threads may be provided on the needle cannula 120, etc. The material of the connecting tube between the needle seat 110 and the needle tube 120 may be stainless steel, aluminum alloy, magnesium alloy, etc., and in other embodiments, the needle seat 110 and the needle tube 120 may be connected by a shearable connecting tube, for example, may be made of plastic materials such as medical polyvinyl chloride (PVC), polyurethane (PU), polypropylene (PP), polyethylene (PE), etc., so as to facilitate shearing.
In this embodiment, the inner diameter of the needle tube 120 used as a guide can be made very small, for example, the inner diameter can be 0.16mm to 0.06mm (30G to 34G), so that compared with the conventional bone tissue puncture needle with the specification of 8G to 15G, the damage to tissues can be reduced during the puncture, pain of a patient can be reduced, even if repeated puncture is needed, the damage to tissues can be reduced as much as possible due to repeated puncture, and the damage to tissues around the sampled tissues can be effectively avoided due to the smaller specification.
As shown in fig. 4, the outer sleeve 200 includes a sleeve fixing portion 210 and a cutting sleeve portion 220. The outer fixing portion 210 is connected to one end of the cutting cannula portion 220, and the outer fixing portion 210 is adapted to remain outside the body. The cutting cannula portion 220 is hollow tubular in configuration with a cutting head 222 at the other end. As shown in fig. 8, a cutting cannula portion 220 can be fitted over the needle cannula 120 and cut along the needle cannula 120 by a cutting head 222 into a target tissue site.
The cutting head 222 has a sharp edge ring. As shown in fig. 5a, 5b and 5c, the sharp edge ring is formed by a plurality of semicircular cutting edges in a ring shape or by a plurality of cutting edges arranged in a worm shape. The cutting head 222 may cut tissue through the sharp edge ring and into the target tissue site.
As shown in fig. 6, the sampling core 300 includes a sampling fixing portion 310 and a sampling sleeve portion 320. The sampling fixing portion 310 is connected to one end of the sampling sleeve portion 320, and the sampling fixing portion 310 can be in limit fit with the outer sleeve fixing portion 210. The sampling sleeve portion 320 is a hollow tubular structure. The other end of the sampling cannula portion 320 has a sampling head 322, and the sampling cannula portion 320 is adapted to be inserted into the cutting cannula portion 220 and is capable of being inserted into a sampling site along the cutting cannula portion 220 and/or the needle cannula 120.
As shown in fig. 7a, 7b, 7c, 7d and 7e, the sampling head 322 may be in various shapes, preferably an elongated head, such as an oblique tip, an elongated head, a polygonal column tip, a hook tip or a worm-shaped tip, which facilitate penetration and sampling.
Referring to fig. 4, 6 and 9, in the present embodiment, the sleeve fixing portion 210 is provided with a stepped stopper hole 212 communicating with the cutting sleeve portion 220. The sampling fixing portion 310 has an annular stepped structure adapted to the limiting hole 212. Further, in the present embodiment, the limiting hole 212 is a three-stage stepped hole, and gradually decreases in inner diameter from an end distant from the cutting sleeve part 220 to an end communicating with the cutting sleeve part 220 until it coincides with the inner diameter of the cutting sleeve part 220; the sampling fixing portion 310 has a two-stage annular step structure, and can be adapted to the front two-stage hole phase of the three-stage step hole. By providing the outer fixing portion 210 and the sampling fixing portion 310 matched with the outer fixing portion, the sampling inner core 300 can be fixed when a tissue sample is obtained, the deep penetration of the sampling sleeve portion 320 is avoided, meanwhile, due to the fact that local anesthesia is usually carried out during biopsy, the outer fixing portion 210 and the sampling fixing portion 310 matched with the outer fixing portion can be used for avoiding the sampling sleeve portion 320 from shifting due to slight vibration of a patient such as twitch and the like, and sampling deviation is caused.
Further, referring to fig. 6, the sampling core 300 of the present embodiment further includes a handle 330. The handle portion 330 is connected to the sampling fixing portion 310. By providing the handle portion 330, the sampling cannula portion 320 can be conveniently rotated, and the sampling cannula portion 320 can be conveniently removed or pierced, thereby facilitating repeated retrieval of tissue samples.
In this embodiment, the length of the needle cannula 120 needs to be longer than the length of the outer cannula 200, and preferably also longer than the length of the sampling core 300, as in one example, the length of the needle cannula 120 may be 8cm to 40cm. It is further preferred that the length of the sampling sleeve portion 320 is greater than the length of the cutting sleeve portion 220, such as in one embodiment, the length of the entire sampling core 300 is 8cm to 18cm.
Still further, in this embodiment, the needle cannula 120, the cutting cannula portion 220 and the sampling cannula portion 320 are provided with scale marks, which is beneficial for an operator to know the penetration depth in time during penetration, and is convenient for penetration and positioning of sampling.
In addition, as shown in FIGS. 10 and 11 a-11 d, in this embodiment, the biopsy sampling device 10 further includes a needle mount 400. Needle mount 400 includes cross beam 410, needle locking screw 420, support bar 430, support caster 440, and caster locking screw 450. The cross member 410 is provided with a fixing hole 412 through which the needle tube 120 passes. One end of the needle locking screw 420 can be screwed into the fixing hole 412 to contact the needle tube 120 to lock and fix the needle tube 120 in the fixing hole 412. The cross member 410 has tooth openings 414 at both sides of the fixing hole 412, respectively. The support bar 430 is arcuate with a pattern of teeth thereon. The number of the support rods 430 is two, the two support rods 430 can respectively pass through the two tooth openings 414 to be meshed with the cross beam 410, and the distance between the two support rods 430 is adjustable. The supporting casters 440 are oval-shaped and have a rubber surface on one side for placement on a support. Support casters 440 are provided at both ends of the support bar 430. The caster locking screw 450 is used to lock and fix the support caster 440 to the support bar 430.
The biopsy sampling device 10 of the present embodiment is particularly suitable for biopsy sampling of small-volume tumors such as bone and soft tissue tumors and/or tissues adjacent to important blood vessels, nerves and the like around the tumors, and can solve the problems of small puncture operation space range and the need of accurate positioning for biopsy. After the guide needle 100 is inserted into a target tissue part, the guide needle can be connected with a syringe through the needle seat 110 to perform local anesthesia and perspective positioning work, other invasive anesthesia operations are not needed, operation steps can be reduced, and pain of a patient is relieved; in addition, since the guide needle 100 only plays a role of guiding or injecting, the guide needle 100 is not used for sampling, the diameter can be very small, so that the operable space around the tumor can be increased, the operation difficulty of repeated puncture can be reduced, and particularly when repeated positioning operation is required, the diameter of the guide needle 100 can be far smaller than that of a traditional bone tissue puncture needle, the pain of a patient in the operation process can be reduced, the damage to surrounding tissues is small, and the postoperative repair of the patient is facilitated; after the needle tube 120 of the guide needle 100 is separated from the needle seat 110, the outer sleeve 200 and/or the sampling inner core 300 can be directly guided by the needle tube 120 until reaching the target tissue site for sampling, and under the guidance of the needle tube 120, the peripheral important tissue organs can be effectively avoided when the outer sleeve 200 and the sampling inner core 300 are inserted into the body, so that the risk of puncture is reduced.
The structure and method of use of the biopsy sampling device of the present invention will be described in further detail with reference to two specific examples.
Example 1
The biopsy sampling device for bone and soft tissue tumors of the embodiment comprises a guide needle, a sampling inner core and an outer sleeve. The guide needle consists of a needle tube and a needle seat, the model of the needle tube is 32G (the inner diameter is 0.11 mm), the length is 35cm, the needle seat uses a needle seat of a single wing-shaped needle bolt, and the needle tube is connected with the needle seat by a plastic adapter tube. The head of the sampling sleeve part of the sampling inner core is in a strip shape, the length is 12cm, and the model is 27G (the inner diameter is 0.21 mm). The length of the cutting sleeve portion of the outer sleeve was 10cm, and the model was 20G (inner diameter: 0.60 mm).
The using method comprises the following steps: in the existing bone tumor volunteer, the tumor tissue is shown in fig. 12, and is characterized by being positioned in the cervical 2 vertebral body (high cervical vertebra), small in tumor volume, only 3cm x 2cm, and the lesion position is close to important tissue organs such as cervical marrow, vertebral artery, esophagus and the like. When a conventional puncture needle is inserted, in order to avoid damaging cervical marrow, vertebral artery, esophagus and the like, the operable space is extremely small, and even if puncture is performed, the puncture angle needs to be adjusted according to perspective or CT images every 3cm, the puncture time is long, and the result of great injury to surrounding tissues caused by repeated puncture can be caused. When the biopsy sampling device of the embodiment is used for biopsy, the biopsy sampling device is positioned under the perspective of the guide needle, and after the biopsy sampling device is acutely penetrated into pathological bone tissue, the biopsy sampling device is connected with a syringe for local infiltration anesthesia. After the anesthesia part of the patient has no touch, the plastic transfer tube is sheared off. The needle tube of the guide needle is sleeved into the cutting sleeve part. In order to prevent the friction force between the cutting sleeve part and the needle tube from causing the position deviation of the needle tube when the cutting sleeve part enters a human body, the needle tube of the guide needle is fixed by using the needle fixing device, and the method comprises the following specific steps: unscrewing the needle locking screw, sleeving the tail part of the needle tube into the fixing hole, and screwing the needle locking screw; inserting a supporting rod into a tooth opening of the cross beam, adjusting the position and the interval of the supporting rod, and fixing the supporting rod; and unscrewing the castor locking screw, adjusting the position of the oval supporting castor (with a rubber friction surface), and screwing the castor locking screw after the whole needle fixing device is stable. The needle head tube of the guide needle is used as a guide, the sharp blade ring of the cutting sleeve part cuts into the tumor part, the needle head tube of the guide needle is withdrawn, and the needle head fixing device is removed. And inserting the sampling inner core until the sampling fixing part is matched with the outer sleeve fixing part, rotating the handle part of the sampling inner core by 360 degrees, and pulling out the sampling inner core after the tumor tissue is completely separated, so as to complete the biopsy operation of the bone tumor.
Example 2
The biopsy sampling device for bone and soft tissue tumors of the embodiment comprises a guide needle, a sampling inner core and an outer sleeve. The guide needle consists of a needle tube and a needle seat, the model of the needle tube is 34G (the inner diameter is 0.06 mm), the length is 15cm, the needle seat uses a needle seat of a double-wing needle bolt, and the needle tube and the needle seat are connected by a stainless steel pre-broken connecting tube. The head of the sampling sleeve part of the sampling inner core is an inclined tip, the length is 14cm, and the model is 32G (the inner diameter is 0.11 mm). The cutting cannula portion of the outer cannula was 10cm in length and was 18G (inner diameter 0.84 mm).
The using method comprises the following steps: the existing fibrosarcoma volunteer has tumor tissue located in the left upper arm, and is characterized by small tumor volume, 3cm x 2cm x 4cm in size, and unclear boundary, and peripheral adjacent nerves and blood vessels. In addition to the deficiencies described in example 1, conventional needles also have a large diameter, which pulls the surrounding soft tissue to slip during access, causing pain to the patient and making itself difficult to secure. When the biopsy sampling device of the embodiment is used for biopsy, the biopsy sampling device is positioned under the CT of the guide needle, and then the biopsy sampling device is connected with the injector for local infiltration anesthesia after acutely penetrating into diseased bone tissues. After the anesthesia part of the patient has no touch, the anesthesia part is sheared off from the pre-crease of the pre-broken connecting pipe. After the sampling fixing part is anastomosed with the outer sleeve fixing part, the needle head pipe of the guide needle is used as guide, the tip of the sampling sleeve part drives the outer sleeve and the sampling inner core to penetrate into the tumor part, the traction to peripheral tissues can be reduced, the guide needle is pulled out, the handle part of the sampling inner core is rotated by 360 degrees, after the tumor tissues are completely separated, the sampling inner core is pulled out, and the tumor tissues are repeatedly obtained until enough tumor tissue samples are obtained.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (7)
1.A biopsy sampling device, comprising:
the guide needle comprises a needle seat and a needle head pipe connected with the needle seat, the needle seat and the needle head pipe are separable, the needle head pipe is used for puncturing to a target tissue position, after the needle head pipe is inserted into the target tissue position, the guide needle can be connected with a syringe through the needle seat, the inner diameter of the needle head pipe is 0.06-0.16 mm, and the specification of the needle head pipe is 30-34G;
The outer sleeve comprises an outer sleeve fixing part and a cutting sleeve part, the outer sleeve fixing part is connected to one end of the cutting sleeve part, the outer sleeve fixing part is used for being left outside the body, the other end of the cutting sleeve part is provided with a cutting head, and the cutting sleeve part can be sleeved on the needle head pipe and can be cut into the target tissue part along the needle head pipe through the cutting head;
The sampling inner core comprises a sampling fixing part and a sampling sleeve part, the sampling fixing part is connected to one end of the sampling sleeve part, the sampling fixing part can be in limit fit with the outer sleeve fixing part, the other end of the sampling sleeve part is provided with a sampling head, and the sampling sleeve part is used for being inserted into the cutting sleeve part and can be inserted into a sampling part along the cutting sleeve part and/or the needle head pipe;
The length of the needle head tube is longer than that of the outer sleeve;
the outer sleeve fixing part is provided with a stepped limiting hole communicated with the cutting sleeve part, and the sampling fixing part is of an annular stepped structure matched with the limiting hole;
The limiting hole is a three-stage stepped hole, and the inner diameter of the limiting hole gradually decreases from one end far away from the cutting sleeve part to one end communicated with the cutting sleeve part until the limiting hole is consistent with the inner diameter of the cutting sleeve part; the sampling fixing part is of a secondary annular stepped structure and can be matched with the front two-stage hole phases of the three-stage stepped hole;
The biopsy sampling device further comprises a needle fixing device, the needle fixing device comprises a cross beam, needle locking screws, supporting rods, supporting casters and caster locking screws, the cross beam is provided with fixing holes through which needle tubes can pass, one ends of the needle locking screws can be screwed into the fixing holes to be in contact with the needle tubes so as to fix the needle tubes in the fixing holes in a locking mode, the cross beam is provided with tooth openings on two sides of the fixing holes respectively, the two supporting rods can respectively pass through the two tooth openings to be meshed with the cross beam and the distance between the two supporting rods is adjustable, the supporting casters are oval and provided with rubber surfaces on one sides, the supporting casters are arranged at two ends of the supporting rods, and the caster locking screws are used for locking and fixing the supporting casters at the end portions of the supporting rods.
2. The biopsy sampling device of claim 1, wherein the needle cannula has a length greater than a length of the sampling core and the sampling cannula portion has a length greater than a length of the cutting cannula portion.
3. The biopsy sampling device of claim 1, wherein the hub is provided with a needle peg that is annular, single winged or double winged.
4. The biopsy sampling device of claim 1, wherein the hub is connected to the needle cannula by a threaded connection tube, a plug-in ferrule, a pre-break connection tube, or a shearable connection tube.
5. The biopsy sampling device of claim 1, wherein the sampling core further comprises a handle portion, the handle portion being coupled to the sampling securement portion.
6. The biopsy sampling device of claim 1, wherein the cutting head has a sharp edge ring formed by a plurality of semicircular edges in a ring or a plurality of edges arranged in a worm-gear pattern;
The sampling head is in the shape of an inclined tip, a strip-shaped head, a polygonal prism-shaped tip, a hook-shaped tip or a worm-shaped tip.
7. The biopsy sampling device of claim 1, wherein the needle cannula, the cutting cannula portion, and the sampling cannula portion are provided with graduation markings.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810254540.0A CN108420464B (en) | 2018-03-26 | 2018-03-26 | Biopsy sampling device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810254540.0A CN108420464B (en) | 2018-03-26 | 2018-03-26 | Biopsy sampling device |
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| CN108420464B true CN108420464B (en) | 2024-05-28 |
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Families Citing this family (6)
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|---|---|---|---|---|
| CN209695247U (en) * | 2018-12-28 | 2019-11-29 | 南京畅丰生物科技有限公司 | A kind of anti-rotation biopsy needle |
| CN109820544A (en) * | 2019-03-29 | 2019-05-31 | 中国医学科学院北京协和医院 | A kind of spinal metastases tumor puncture channel and equipment |
| CN111067576A (en) * | 2019-12-30 | 2020-04-28 | 柳河 | Shovel needle and medical needle group |
| CN111839596B (en) * | 2020-06-12 | 2022-05-13 | 珠海市人民医院 | Clamping type conveniently-folded multi-section sampling rod |
| CN112336435A (en) * | 2020-11-12 | 2021-02-09 | 河北省胸科医院 | A positioning device for puncture sampling and using method thereof |
| CN113100887B (en) * | 2021-04-06 | 2022-05-06 | 首都医科大学宣武医院 | A tertiary puncture cannula assembly for trigeminal meniscus balloon compression |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5388589A (en) * | 1991-09-27 | 1995-02-14 | Dlp, Inc. | Core biopsy needle with spacer |
| CN101385883A (en) * | 2003-05-02 | 2009-03-18 | 贝克顿迪肯森公司 | Medical device having releasable retainer |
| CN203059860U (en) * | 2013-02-05 | 2013-07-17 | 李爱君 | Cannula split-type puncture needle for chest puncture and drainage |
| CN203988146U (en) * | 2014-07-17 | 2014-12-10 | 王松 | A kind of percutaneous vertebral body aspiration biopsy multi-point sampling tool kit |
| CN204133570U (en) * | 2014-10-17 | 2015-02-04 | 范晓希 | A kind of anhydrous alcohol needle guard part with positioning function |
| CN104667406A (en) * | 2015-02-15 | 2015-06-03 | 扬州市江洲医疗器械有限公司 | Double-tube jointed puncture needle |
| JP2016052451A (en) * | 2014-09-04 | 2016-04-14 | 株式会社八光 | Preoperative percutaneous marking equipment not requiring visceral pleura centesis in thoracoscopic surgery |
| CN208822829U (en) * | 2018-03-26 | 2019-05-07 | 中山大学附属第一医院 | biopsy sampling device |
-
2018
- 2018-03-26 CN CN201810254540.0A patent/CN108420464B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5388589A (en) * | 1991-09-27 | 1995-02-14 | Dlp, Inc. | Core biopsy needle with spacer |
| CN101385883A (en) * | 2003-05-02 | 2009-03-18 | 贝克顿迪肯森公司 | Medical device having releasable retainer |
| CN203059860U (en) * | 2013-02-05 | 2013-07-17 | 李爱君 | Cannula split-type puncture needle for chest puncture and drainage |
| CN203988146U (en) * | 2014-07-17 | 2014-12-10 | 王松 | A kind of percutaneous vertebral body aspiration biopsy multi-point sampling tool kit |
| JP2016052451A (en) * | 2014-09-04 | 2016-04-14 | 株式会社八光 | Preoperative percutaneous marking equipment not requiring visceral pleura centesis in thoracoscopic surgery |
| CN204133570U (en) * | 2014-10-17 | 2015-02-04 | 范晓希 | A kind of anhydrous alcohol needle guard part with positioning function |
| CN104667406A (en) * | 2015-02-15 | 2015-06-03 | 扬州市江洲医疗器械有限公司 | Double-tube jointed puncture needle |
| CN208822829U (en) * | 2018-03-26 | 2019-05-07 | 中山大学附属第一医院 | biopsy sampling device |
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| CN108420464A (en) | 2018-08-21 |
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