[go: up one dir, main page]

CN108404095A - 一种活血通络用于乳腺增生治疗的中药透皮贴剂 - Google Patents

一种活血通络用于乳腺增生治疗的中药透皮贴剂 Download PDF

Info

Publication number
CN108404095A
CN108404095A CN201810508504.2A CN201810508504A CN108404095A CN 108404095 A CN108404095 A CN 108404095A CN 201810508504 A CN201810508504 A CN 201810508504A CN 108404095 A CN108404095 A CN 108404095A
Authority
CN
China
Prior art keywords
parts
layer
medicine
film layer
transdermal patch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810508504.2A
Other languages
English (en)
Inventor
许汉珍
许建儿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuzhou Xinmeiyuan Biological Medicine Engineering Co Ltd
Original Assignee
Fuzhou Xinmeiyuan Biological Medicine Engineering Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuzhou Xinmeiyuan Biological Medicine Engineering Co Ltd filed Critical Fuzhou Xinmeiyuan Biological Medicine Engineering Co Ltd
Priority to CN201810508504.2A priority Critical patent/CN108404095A/zh
Publication of CN108404095A publication Critical patent/CN108404095A/zh
Priority to PCT/CN2018/109988 priority patent/WO2019223218A1/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/008—Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)

Abstract

本发明公开了一种活血通络用于乳腺增生治疗的中药透皮贴剂，包括粘胶层、能量层、磁化层、药膜层及背衬层，能量层由位于其上表面的背衬层和位于其下表面的不透气膜包覆，不透气膜的内侧设有永磁体和药膜层，永磁体位于不透气膜和药膜层之间；粘胶层外侧设有背衬层；药膜层由中药组分和高分子材料复合制得，高分子材料为PLA和PHB复合而成。本发明将中药组分包覆于由PLA和PHB复合制得的高分子材料内，能量层中的发热物质与氧气接触而自发产生热量作用于药膜层，能够促进药效迅速释放，对乳腺增生引起的疼痛、肿胀起到很好缓解和消散作用，此外对颈椎病、腰腿痛、慢性劳损、脊椎痛、风湿性关节炎、骨关节炎等慢性病也有很好的疗效。

Description

一种活血通络用于乳腺增生治疗的中药透皮贴剂
技术领域
本发明属于中药贴剂技术领域，具体涉及一种活血通络、临床上用于治疗乳腺增生的中药透皮给药贴剂。
背景技术
乳腺增生病是以腺泡上皮、导管上皮及纤维结缔组织一种或多种组织增生为主要病理改变的乳房疾病，是非肿瘤、非炎症性的乳腺上皮增生性疾患，属于中医“乳癖”范畴。发病年龄集中于20～50岁，50岁以后发病率急骤下降。其发病率占育龄妇女的40％左右，占全部乳房病的75％，是最常见的乳房疾病。一般认为黄体素不足，使月经周期中乳腺增生和复旧不全，日久形成本病。
现代中医认为乳腺增生病的发生由肝郁气滞，或肝肾虚损，冲任失调，或痰凝血淤而成。中医治疗乳腺增生病，历史悠久，疗效确切且无明显毒副反应，复发率低。中医以整体观念对本病辨证论治，辨证与辨病相结合，整体与局部相结合，内治与外治相结合，长期治疗与短期治疗相结合，通过疏肝理气、活血化瘀、散结，从多方面、多角度起到调整内分泌，标本兼治的作用。尤其是中医外治法针对乳腺增生病患者以局部症状和体征为主的特点，采用集成外治治疗能直达病所，是治疗乳腺增生病的重要途径之一。
本发明的中药透皮给药制剂是集药疗、温炙、磁疗、热疗于一体的新型多功能治疗贴，以其药疗、温炙、磁疗、热疗等直接作用于乳腺病变部位，可通过对丰富的乳腺血管和经络或穴位的刺激，改善乳腺病变部位局部的微循环，起到疏通经络，活血化瘀、软坚散结作用，达到减轻症状，缓解乳腺小叶增生引起的疼痛，对乳腺增生病有辅助治疗作用。
目前市面上用于乳腺增生的药剂贴中的药物成分，往往是将中药材直接粉碎后装包使用，这样有效成份不易释放，皮肤吸收甚微，药物的生物效价下降，而且药效损耗大，影响临床效果。因此，发明一种新型的活血通络的多功能中药制剂是非常必要的。
发明内容
本发明的目的在于提供一种活血通络的中药透皮贴剂，其能够有效改善女性乳腺增生引起的乳房疼痛、乳房肿块、乳头溢液等症状。由于该药物具有活血通络功能，对颈椎病、腰腿痛、慢性劳损、脊椎痛、风湿性关节炎、骨关节炎等慢性病也有很好的疗效。
为实现上述目的，本发明采用如下技术方案：
一种活血通络的中药透皮贴剂，包括粘胶层、能量层、永磁体（磁化层）、药膜层及背衬层，所述能量层由位于其上表面的胶粘层和位于其下表面的不透气膜包覆，所述不透气膜的内侧设有永磁体和药膜层，永磁体位于不透气膜和药膜层之间；所述粘胶层的外侧设有背衬层；所述药膜层的下表面还设有一层离型纸覆盖在药膜层和粘胶层上。使用时，撕去药膜层下方的离型纸，将中药透皮制剂贴于患处，使药膜层直接与患处皮肤接触。上述的不透气膜的内侧是指靠近人体皮肤的一侧，粘胶层的外侧是指远离人体皮肤的一侧。
进一步的，所述背衬层采用透气的无纺布制成。
进一步的，所述能量层内含发热物质。
进一步的，所述不透气膜由不透气材料制成，所述不透气材料包括不透气塑胶、不透气布料。
进一步的，所述药膜层由中药组分和高分子材料复合制得。本发明将中药组分包覆于由聚乳酸和聚3-羟基丁酸酯复合制得的高分子材料内，配制成药膜层。药膜层中的中药组分由以下重量份的药材原料制成：鹿衔草5~7份、 蚤休6~10份、桃仁3~5份、红花2~4份、乳香3~5份、没药3~5份、茜草3~5份、葵蓬菜8-10份、柴胡3~5份、枳壳2~4份、蒲公英4~8份、三棱3~5份、莪术3~5份、漏芦2~4份、山慈菇2~4份、大黄3~5份、干姜2~4份、蜈蜙3~5份、青皮1~3份、全蝎4~6份、水蛭4~6份、雪上一枝蒿1~3份、秦艽1~3份、阿魏2~4份和血竭4~8份；所述高分子材料为聚乳酸（PLA）和聚3-羟基丁酸酯（PHB）。
所述药膜层的制备方法具体包括以下步骤：
1）按重量份数计，将鹿衔草5~7份、蚤休6~10份、桃仁3~5份、红花2~4份、乳香3~5份、没药3~5份、茜草3~5份、葵蓬菜8-10份、柴胡3~5份、枳壳2~4份、蒲公英4~8份、三棱3~5份、莪术3~5份、漏芦2~4份、山慈菇2~4份、大黄3~5份、干姜2~4份、蜈蜙3~5份、青皮1~3份、全蝎4~6份、水蛭4~6份、雪上一枝蒿1~3份、秦艽1~3份、阿魏2~4份和血竭4~8份粉碎后，加入其重量3-5倍85wt%的乙醇回流提取2次，每次1小时，合并两次提取液，过滤并回收乙醇；将所得提取液减压浓缩并干燥后，过80-100目筛，得到中药组分；
2）用乙酸乙酯分别溶解PLA和PHB，分别配制成8~10wt%的溶液，室温下将两种溶液混合，制得PLA/ PHB共混物，备用；
3）取步骤1）制得的中药组分溶于乙醇中，得到中药液，将所得中药液加入到步骤2）制得的PLA/PHB共混物中，磁力搅拌6h，浇铸成膜，室温下真空干燥48h以除去溶剂，制得所述药膜层。
进一步的，步骤2）中，PLA和PHB的质量比为(1~5):5。
进一步的，所述中药组分的质量与PLA和PHB总质量的比值为1:9。
本发明的显著优点在于：
（1）本发明将中药组分包覆于由聚乳酸和聚3-羟基丁酸酯复合制得的高分子材料内，能量层中含有的发热物质与氧气接触而自发产生热量作用于药膜层，能够使得药物快速释放，并且由于高分子材料的包覆，使得药效作用持续时间延长，维持稳定、持久的血药浓度，同时降低药物的毒性和副作用；对人体的乳房、子宫或关节部位的痛症能够起到很好的治疗效果；且随着能量层的温度提高，可促进药膜层中各药效成分的挥发、渗透，从而进一步达到良好的活血通络，行气止痛的效果；
（2）本发明在中药透皮贴剂中加入永磁体，一方面是利用其磁力线的穿透作用，达到舒经活络、调理气血的效果，另一方面，磁石吸收能量层所释放的热量后，通过热磁场效应增强，能够激发药膜层中所含的挥发油等药效成分，使其分解成更小的分子，从而有助于促进药效成分的透皮吸收；
（3）本发明中药透皮贴剂集药疗、温灸、热疗、磁疗于一体，能够有效改善女性乳腺增生引起的乳房疼痛、乳房肿块、乳头溢液等症状；对颈椎病、腰腿痛、慢性劳损、脊椎痛、风湿性关节炎、骨关节炎等慢性病也有很好的疗效。
附图说明
图1为本发明中药透皮贴剂的结构示意图；其中，1-粘胶层，2-能量层（内含发热物质），3-永磁体（磁化层），4-药膜层，5-背衬层，6-不透气膜，7-离型纸；
图2为本发明图1的仰视图。
具体实施方式
实施例
如图1、2所示，本发明的中药透皮贴剂，包括粘胶层1、能量层2（内含发热物质）、永磁体（磁化层）3、药膜层4和背衬层5；能量层2由位于其上表面的的粘胶层1和位于其下表面的不透气膜6包覆，不透气膜6的内侧设有永磁体3和药膜层4，所述永磁体3位于不透气膜6和药膜层2之间；所述粘胶层1的外侧设有背衬层5。
进一步的，所述背衬层5采用无纺布制成。
进一步的，所述不透气膜6由不透气材料制成，所述不透气材料包括不透气塑胶、不透气布料。
进一步的，所述药膜层4的下表面还设有一层离型纸7覆盖在药膜层4和粘胶层1上。
使用时，将该中药透皮贴剂从密封袋中取出，掀去覆盖在粘胶层及药物层上的离型纸，然后贴于乳房的疼痛部位或是关节患处。此时，空气通过背衬层进入能量层，引起发热物质发热，达到热疗的效果，并使药膜层和永磁体的温度提高，促进药物释放，以进一步达到药疗和磁疗的效果。
为了使本发明所述的内容更加便于理解，下面结合具体实施方式对本发明所述的技术方案做进一步的说明，但是本发明不仅限于此。
实施例1
中药透皮贴剂中的药物层由中药组分和高分子材料复合制得；所述药物层的制备方法具体包括以下步骤：
1）按重量份数计，将鹿衔草5份、蚤休6份、桃仁3份、红花2份、乳香3份、没药3份、茜草3份、葵蓬菜8份、柴胡3份、枳壳2份、蒲公英4份、三棱3份、莪术3份、漏芦2份、山慈菇2份、大黄3份、干姜2份、蜈蜙3份、青皮1份、全蝎4份、水蛭4份、雪上一枝蒿1份、秦艽1份、阿魏2份和血竭4份粉碎后，加入其重量3倍85wt%的乙醇回流提取2次，每次1小时，合并两次提取液，过滤并回收乙醇；将所得提取液减压浓缩并干燥后，过80目筛，得到中药组分；
2）用乙酸乙酯分别溶解PLA和PHB（其中PLA和PHB的质量比为1:5），分别配制成8wt%的溶液，室温下将两种溶液混合，制得PLA/ PHB共混物，备用；
3）取步骤1）制得的中药组分溶于乙醇中，得到中药液，将所得中药液加入到步骤2）制得的PLA/PHB共混物中，磁力搅拌6h，浇铸成膜，室温下真空干燥48h以除去溶剂，制得所述药物层；所述中药组分的质量与PLA和PHB总质量的比值为1:9。
实施例2
中药透皮贴剂中的药物层由中药组分和高分子材料复合制得；所述药物层的制备方法具体包括以下步骤：
1）按重量份数计，将鹿衔草7份、蚤休10份、桃仁5份、红花4份、乳香5份、没药5份、茜草5份、葵蓬菜9份、柴胡5份、枳壳4份、蒲公英8份、三棱5份、莪术5份、漏芦4份、山慈菇4份、大黄5份、干姜4份、蜈蜙5份、青皮3份、全蝎6份、水蛭6份、雪上一枝蒿3份、秦艽3份、阿魏4份和血竭8份粉碎后，加入其重量5倍85wt%的乙醇回流提取2次，每次1小时，合并两次提取液，过滤并回收乙醇；将所得提取液减压浓缩并干燥后，过80目筛，得到中药组分；
2）用乙酸乙酯分别溶解PLA和PHB（其中PLA和PHB的质量比为1:1），分别配制成10wt%的溶液，室温下将两种溶液混合，制得PLA/ PHB共混物，备用；
3）取步骤1）制得的中药组分溶于乙醇中，得到中药液，将所得中药液加入到步骤2）制得的PLA/PHB共混物中，磁力搅拌6h，浇铸成膜，室温下真空干燥48h以除去溶剂，制得所述药物层；所述中药组分的质量与PLA和PHB总质量的比值为1:9。
实施例3
中药透皮贴剂中的药物层由中药组分和高分子材料复合制得；所述药物层的制备方法具体包括以下步骤：
1）按重量份数计，将鹿衔草6份、蚤休8份、桃仁4份、红花3份、乳香4份、没药4份、茜草4份、葵蓬菜10份、柴胡4份、枳壳3份、蒲公英6份、三棱4份、莪术4份、漏芦3份、山慈菇3份、大黄4份、干姜3份、蜈蜙4份、青皮2份、全蝎5份、水蛭5份、雪上一枝蒿2份、秦艽2份、阿魏3份和血竭6份粉碎后，加入其重量4倍85wt%的乙醇回流提取2次，每次1小时，合并两次提取液，过滤并回收乙醇；将所得提取液减压浓缩并干燥后，过100目筛，得到中药组分；
2）用乙酸乙酯分别溶解PLA和PHB（其中PLA和PHB的质量比为3:5），分别配制成9wt%的溶液，室温下将两种溶液混合，制得PLA/ PHB共混物，备用；
3）取步骤1）制得的中药组分溶于乙醇中，得到中药液，将所得中药液加入到步骤2）制得的PLA/PHB共混物中，磁力搅拌6h，浇铸成膜，室温下真空干燥48h以除去溶剂，制得所述药物层；所述中药组分的质量与PLA和PHB总质量的比值为1:9。
以上所述仅为本发明的较佳实施例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。

Claims (10)

1.一种活血通络的中药透皮贴剂，包括粘胶层、能量层、永磁体、药膜层及背衬层，其特征在于：所述能量层由位于其上表面的胶粘层和位于其下表面的不透气膜包覆，所述不透气膜的内侧设有永磁体和药膜层，所述永磁体位于不透气膜和药膜层之间；所述粘胶层的外侧设有背衬层；所述药膜层由中药组分和高分子材料复合制得。
2. 根据权利要求1所述的中药透皮贴剂，其特征在于：药膜层中的中药组分由以下重量份的药材原料制成：鹿衔草5~7份、 蚤休6~10份、桃仁3~5份、红花2~4份、乳香3~5份、没药3~5份、茜草3~5份、葵蓬菜8-10份、柴胡3~5份、枳壳2~4份、蒲公英4~8份、三棱3~5份、莪术3~5份、漏芦2~4份、山慈菇2~4份、大黄3~5份、干姜2~4份、蜈蜙3~5份、青皮1~3份、全蝎4~6份、水蛭4~6份、雪上一枝蒿1~3份、秦艽1~3份、阿魏2~4份和血竭4~8份。
3.根据权利要求2所述的中药透皮贴剂，其特征在于：所述药膜层中的中药组分的制备方法为：按重量份数计，将鹿衔草5~7份、蚤休6~10份、桃仁3~5份、红花2~4份、乳香3~5份、没药3~5份、茜草3~5份、葵蓬菜8-10份、柴胡3~5份、枳壳2~4份、蒲公英4~8份、三棱3~5份、莪术3~5份、漏芦2~4份、山慈菇2~4份、大黄3~5份、干姜2~4份、蜈蜙3~5份、青皮1~3份、全蝎4~6份、水蛭4~6份、雪上一枝蒿1~3份、秦艽1~3份、阿魏2~4份和血竭4~8份粉碎后，加入其重量3-5倍85wt%的乙醇回流提取2次，每次1小时，合并两次提取液，过滤并回收乙醇；将所得提取液减压浓缩并干燥后，过80-100目筛，得到中药组分。
4.根据权利要求1所述的中药透皮贴剂，其特征在于：所述高分子材料为聚乳酸和聚3-羟基丁酸酯。
5.根据权利要求1所述的中药透皮贴剂，其特征在于：所述药膜层的制备方法具体包括以下步骤：
1）用乙酸乙酯分别溶解聚乳酸和聚3-羟基丁酸酯，分别配制成8~10wt%的溶液，室温下将两种溶液混合，制得聚乳酸/聚3-羟基丁酸酯共混物，备用；
2）取中药组分溶于乙醇中，得到中药液，将所得中药液加入到步骤1）制得的聚乳酸/聚3-羟基丁酸酯共混物中，磁力搅拌6h，浇铸成膜，室温下真空干燥48h以除去溶剂，制得所述药膜层。
6.根据权利要求5所述的中药透皮贴剂，其特征在于：步骤1）中，聚乳酸和聚3-羟基丁酸酯的质量比为(1~5):5。
7.根据权利要求5所述的中药透皮贴剂，其特征在于：所述中药组分的质量与聚乳酸和聚3-羟基丁酸酯总质量的比值为1:9。
8.根据权利要求1所述的中药透皮贴剂，其特征在于：所述背衬层采用透气的无纺布制成。
9.根据权利要求1所述的中药透皮贴剂，其特征在于：所述能量层内含发热物质。
10.根据权利要求1所述的中药透皮贴剂，其特征在于：所述药膜层的下表面还设有一层离型纸覆盖在药膜层和粘胶层上。
CN201810508504.2A 2018-05-24 2018-05-24 一种活血通络用于乳腺增生治疗的中药透皮贴剂 Pending CN108404095A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201810508504.2A CN108404095A (zh) 2018-05-24 2018-05-24 一种活血通络用于乳腺增生治疗的中药透皮贴剂
PCT/CN2018/109988 WO2019223218A1 (zh) 2018-05-24 2018-10-12 一种活血通络用于乳腺增生治疗的中药透皮贴剂

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810508504.2A CN108404095A (zh) 2018-05-24 2018-05-24 一种活血通络用于乳腺增生治疗的中药透皮贴剂

Publications (1)

Publication Number Publication Date
CN108404095A true CN108404095A (zh) 2018-08-17

Family

ID=63140450

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810508504.2A Pending CN108404095A (zh) 2018-05-24 2018-05-24 一种活血通络用于乳腺增生治疗的中药透皮贴剂

Country Status (2)

Country Link
CN (1) CN108404095A (zh)
WO (1) WO2019223218A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110326827A (zh) * 2019-08-06 2019-10-15 江苏万鸿健康科技有限公司 一种防治乳腺增生的保健胸垫
WO2019223218A1 (zh) * 2018-05-24 2019-11-28 Xu Hanzhen 一种活血通络用于乳腺增生治疗的中药透皮贴剂

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102335369A (zh) * 2010-07-22 2012-02-01 潘立芝 一种治疗乳腺增生的中药贴
CN102552818A (zh) * 2012-02-15 2012-07-11 李新民 治疗乳腺疾病的外用药物组合物及其制备方法
CN104826016A (zh) * 2015-05-14 2015-08-12 成都市康飞药业有限公司 一种治疗乳腺增生的药物组合物及其制备方法和用途
CN107617083A (zh) * 2017-09-14 2018-01-23 王风连 治疗乳腺增生的贴剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN204133878U (zh) * 2014-10-07 2015-02-04 胡海帆 用于治疗子宫肌瘤和慢性盆腔炎的药膏贴
CN205360237U (zh) * 2016-02-06 2016-07-06 绍兴易邦医用品有限公司 一种敷贴
CN107648530A (zh) * 2017-11-02 2018-02-02 青海喜玛拉雅药业有限公司 止痛贴
CN108404095A (zh) * 2018-05-24 2018-08-17 福州鑫美源生物医药工程有限公司 一种活血通络用于乳腺增生治疗的中药透皮贴剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102335369A (zh) * 2010-07-22 2012-02-01 潘立芝 一种治疗乳腺增生的中药贴
CN102552818A (zh) * 2012-02-15 2012-07-11 李新民 治疗乳腺疾病的外用药物组合物及其制备方法
CN104826016A (zh) * 2015-05-14 2015-08-12 成都市康飞药业有限公司 一种治疗乳腺增生的药物组合物及其制备方法和用途
CN107617083A (zh) * 2017-09-14 2018-01-23 王风连 治疗乳腺增生的贴剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘世任: "《药剂学知识新编》", 31 December 2016, 西安交通大学出版社 *
刘伟著: "《生物高分子材料及其应用研究》", 30 November 2017, 电子科技大学出版社 *
林玲等: "易至牌乳腺贴治疗61例乳腺增生的临床研究", 《中外健康文摘》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019223218A1 (zh) * 2018-05-24 2019-11-28 Xu Hanzhen 一种活血通络用于乳腺增生治疗的中药透皮贴剂
CN110326827A (zh) * 2019-08-06 2019-10-15 江苏万鸿健康科技有限公司 一种防治乳腺增生的保健胸垫

Also Published As

Publication number Publication date
WO2019223218A1 (zh) 2019-11-28

Similar Documents

Publication Publication Date Title
CN100531773C (zh) 一种治疗疼痛的膏药及其制作方法
CN101658331B (zh) 一种防治乳腺疾病的中草药粘贴胸衣
CN1500501A (zh) 治疗子宫肌瘤的中药复方制剂
CN104523969A (zh) 一种治疗肾阳虚痹证的药物
CN106074752A (zh) 一种治疗骨病的外用中药组合物
CN106110259B (zh) 治疗脾肾阳虚症状的中药巴布剂及其制备方法
CN102058673A (zh) 一种祛风除湿的中药组合物及其制备方法
CN1262299C (zh) 防治冠心病心绞痛的中药贴膜及其制备方法
CN108404095A (zh) 一种活血通络用于乳腺增生治疗的中药透皮贴剂
CN103623188A (zh) 一种治疗骨性膝关节炎的中药巴布膏及其制备方法
CN100493595C (zh) 红外止咳贴
CN1277566C (zh) 一种治疗痹症疼痛疾病药的制备方法
CN1232279C (zh) 一种降血脂的中药
CN105816832A (zh) 治疗风寒腰痛的中药凝胶膏帖及其制备方法
CN102580030B (zh) 具有降血糖功效的外用中药组合物、制剂及其制备方法
CN1709336A (zh) 红外鼻炎贴及制备方法
CN108355042A (zh) 一种消炎止痛药膏及其制备方法
CN102614464A (zh) 一种治疗糖尿病足的中药组合物
CN105031380A (zh) 一种用于孕妇口腔局部麻醉的药物及其制备方法
CN104001100A (zh) 一种治疗picc静脉血栓的中药组合物及其制备方法
CN102008527A (zh) 治疗痔疮的外敷中药粉剂及透气贴
CN109718334A (zh) 一种用于风湿骨病及颈肩腰腿痛的贴膏剂制作方法
CN105920189A (zh) 一种治疗肝肾亏虚型足跟痛的中药组合物及其制备方法
CN104971315A (zh) 一种治疗外伤创面感染的抗菌凝胶剂与及其制备方法
CN103977260A (zh) 一种用于治疗坐骨神经痛的药物及制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180817