CN108355257B - Beam shaping body for neutron capture therapy - Google Patents
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- CN108355257B CN108355257B CN201810275965.XA CN201810275965A CN108355257B CN 108355257 B CN108355257 B CN 108355257B CN 201810275965 A CN201810275965 A CN 201810275965A CN 108355257 B CN108355257 B CN 108355257B
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Abstract
A beam shaper for neutron capture therapy, the beam shaper comprising a beam inlet, a target, a retarder adjacent to the target, a reflector surrounding the retarder, and a beam outlet, the retarder being replaceable to adjust the retardance of the retarder to neutrons. The beam shaping body for neutron capture treatment only needs to select the retarders made of different materials according to actual requirements of indexes such as tumor on neutron energy regions and neutron beam flux to adjust the retardance of neutrons, so that the same medical equipment can be used for treating different patients, and the neutron shaping body is simple in structure and high in applicability.
Description
This application is a divisional application of the CN106552323A application with the filing date of the parent application being 2015, 9, 30 and application number Z L201510643065.2, entitled beam shaper for neutron capture therapy.
Technical Field
The present invention relates to a beam shaper, in particular a beam shaper for neutron capture therapy.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linacs, electron beams, etc. has become one of the main means of cancer treatment. However, the traditional photon or electron therapy is limited by the physical conditions of the radiation, and can kill tumor cells and damage a large amount of normal tissues in the beam path; in addition, due to the difference in the sensitivity of tumor cells to radiation, conventional radiotherapy is often ineffective in treating malignant tumors with relatively high radiation resistance, such as multiple glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma).
In order to reduce the radiation damage of normal tissues around tumor, the target therapy concept in chemotherapy (chemotherapy) is applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high Relative Biological Effect (RBE) are also actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. Wherein, the neutron capture treatment combines the two concepts, such as boron neutron capture treatment, and provides better cancer treatment selection than the traditional radioactive rays by the specific accumulation of boron-containing drugs in tumor cells and the precise neutron beam regulation.
Boron Neutron Capture Therapy (BNCT) utilizes Boron-containing (B: (B-N-C-B-N-C-10B) Drug to thermal neutronHaving a high trapping cross-section, by10B(n,α)7L i neutron capture and fission reaction generation4He and7l i two heavily charged particles referring to figures 1 and 2, there are shown schematic diagrams of boron neutron capture reactions and10B(n,α)7l i neutron capture nuclear reaction equation, the average energy of two charged particles is about 2.33MeV, with high linear transfer (L initial energy transfer, &lTtTtransfer = L "&gTtL &lTt/T &gTtET), short range characteristics, and the linear energy transfer and range of α particles are 150keV/μm, 8 μm respectively, and7l i heavy-load particles are 175 keV/mum and 5μm, the total range of the two particles is about equal to one cell size, so the radiation damage to organism can be limited at cell level, when boron-containing medicine selectively gathers in tumor cells, matching with proper neutron source, the purpose of local killing tumor cells can be achieved without causing too much damage to normal tissue.
The effect of boron neutron capture therapy is also called binary cancer therapy (binary cancer therapy) because the effect depends on the boron-containing drug concentration and the quantity of thermal neutrons at the tumor cell position; it is known that, in addition to the development of boron-containing drugs, the improvement of neutron source flux and quality plays an important role in the research of boron neutron capture therapy.
However, most of the beam shaping bodies in the prior art for boron neutron capture therapy are designed to be of an integral fixed structure, the quality of the neutron beam output by such a beam shaping body is often fixed, but the requirement on the quality of the neutron beam is not uniform in the actual therapy process. The position, depth and type of the tumor may vary from patient to patient, which results in different requirements for the quality of the neutron beam during the treatment process, and the beam shaping body of the integral fixed structure in the prior art cannot adjust the quality of the neutron beam according to the specific condition of the tumor of the patient to match the actual condition of the patient for treatment.
Therefore, there is a need to provide a new technical solution to solve the above problems.
Disclosure of Invention
In order to solve the above problems, the present invention provides a beam shaper for neutron capture therapy, the beam shaper comprising a beam inlet, a target, a retarder adjacent to the target, a reflector surrounding the retarder, and a beam outlet, the retarder being replaceable to adjust the retardance of the retarder to neutrons.
Further, the retarder comprises a base part positioned behind the target and an expansion part arranged separately from the base part, and the expansion part can be replaced independently to adjust the retarding capacity of the retarder.
Further, the base portion is adjacent to the rear of the target and fixed to the target, and the extension portion is attached to the rear of the base portion and adjacent to the base portion.
Further, the extension part at least comprises a first extension part and a second extension part, the first extension part is arranged behind the base part and is adjacent to the base part, the second extension part is arranged behind the first extension part and is adjacent to the first extension part, and the first extension part and the second extension part can be replaced independently.
Furthermore, the reflector is provided with a guide groove corresponding to the expansion part and extending to the rear of the base part, the guide groove is provided with a slide rail, and the expansion part is arranged in the guide groove and then moves to the rear of the base part through the slide rail and is adjacent to the base part; the guide grooves at least comprise a first guide groove corresponding to the first expansion part and a second guide groove corresponding to the second expansion part; when the first expansion part and the second expansion part have the same structure size and are made of different materials, the first expansion part and the second expansion part can be respectively installed in the first guide groove or the second guide groove; when the first expansion part and the second expansion part are different in structural size and different in material, the first expansion part is installed in the first guide groove, and the second expansion part is installed in the second guide groove.
When the extension part is arranged at the rear of the base part through the slide rail, the supplementary reflector and the reflector surrounding the base part reflect scattered neutrons together.
Furthermore, the reflector is provided with a rotating shaft, the rotating shaft is provided with a turntable which is positioned behind the base part and can rotate relative to the base part, and the expansion part is arranged in the turntable, rotates along with the turntable to move to the rear part of the base part and is adjacent to the base part; the rotating discs at least comprise a first rotating disc corresponding to the first expansion part and a second rotating disc corresponding to the second expansion part; when the first expansion part and the second expansion part have the same structure size and are made of different materials, the first expansion part and the second expansion part can be installed in the first rotary disc or the second rotary disc respectively; when the first expansion part and the second expansion part are different in structural size and different in material, the first expansion part is installed in the first rotary disc, and the second expansion part is installed in the second rotary disc.
Further, the reflector further includes a supplementary reflector provided on an outer periphery of the extension portion, and when the extension portion is rotatably attached to a rear side of the base portion about the rotation axis, the supplementary reflector reflects the scattered neutrons together with the reflector surrounding the outside of the base portion.
Further, the base portion, the first extension portion and the second extension portion may be made of Al, Pb, Ti, Bi, C, D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3Any one or more of them.
Further, the reflector is made of at least one of Pb or Ni, and a material of the supplementary reflector is the same as a material of the reflector.
Compared with the prior art, the method has the following beneficial effects: the utility model provides a beam integer for neutron capture treatment designs into basilar part and extension portion with the retarder, set up the extension portion into two parts that can change, at the actual treatment in-process, the extension portion that combines the specific state of an illness of patient (the depth of patient's tumour) to select different materials is changed, thereby make the retarder carry out the retardance to the neutron beam, thereby obtain the neutron beam quality that is fit for the patient at the treatment in-process actual need, moreover, the steam generator is simple in structure, and the application is flexible.
Drawings
FIG. 1 is a schematic diagram of the structure of a beam shaper for neutron capture therapy according to the present application;
FIG. 2 is a schematic diagram of a boron neutron capture reaction;
FIG. 3 is a schematic structural diagram illustrating an extension installed using a guide slot according to an embodiment of the present disclosure;
fig. 4 is a schematic structural diagram of an extension installed by using a turntable according to a second embodiment of the present application.
Detailed Description
Neutron capture therapy has been increasingly used in recent years as an effective means of treating cancer, with boron neutron capture therapy being the most common, the neutrons that supply boron neutron capture therapy being supplied by nuclear reactors or accelerators. In the embodiments of the present application, the basic components of accelerator boron neutron capture therapy are generally composed of an accelerator for accelerating charged particles (such as protons, deuterons, etc.), a target and heat removal system, and a beam shaper, wherein the accelerated charged particles react with a metal target to generate neutrons, and the appropriate nuclear reactions are selected according to the desired neutron yield and energy, the available energy and current of the accelerated charged particles, the physical properties of the metal target, and the like, and the nuclear reactions in question are commonly referred to as7Li(p,n)7Be and9Be(p,n)9the energy thresholds for the two nuclear reactions are 1.881MeV and 2.055MeV, respectively, since the ideal neutron source for boron neutron capture therapy is epithermal neutrons at keV energy levels, theoretically if a metallic lithium target is bombarded with protons with energy only slightly above the threshold, relatively low-energy neutrons can Be produced, without much moderation treatment, and can Be used clinically, however, the interaction cross-section of the protons of lithium metal (L i) and beryllium metal (Be) with the threshold energy is not high, and to produce a sufficiently large neutron flux, the protons of higher energy are usually selected to initiate the nuclear reaction.
The ideal target material should have the characteristics of high neutron yield, neutron energy distribution close to the super-thermal neutron energy region, no generation of too much intense penetrating radiation, safety, cheapness, easy operation, high temperature resistance and the like, but actually, a nuclear reaction meeting all requirements cannot be found, and the target material made of lithium metal is adopted in the embodiment of the invention. It is well known to those skilled in the art that the material of the target may be made of other metallic materials than those mentioned above.
The requirements for the heat removal system vary depending on the nuclear reaction chosen, e.g.7Li(p,n)7Be has a higher requirement for a heat removal system due to the difference between the melting point and the thermal conductivity of the metal target (lithium metal)9Be(p,n)9B is high. In the embodiment of the invention7Li(p,n)7Nuclear reaction of Be.
In addition, in the actual treatment process using the neutron capture treatment technology, the specific conditions (the position and depth of the tumor and the type of the tumor) of the tumors of different patients may be different, so the specific requirements (the specific range of the neutron energy region, the neutron beam flux, even the forward nature of the neutron beam, and the like) on the quality of the neutron beam generated after the proton and the target material have nuclear reaction may be different. In order to make the neutron capture therapy more flexible and more accurate to be applied to the actual therapy process of tumor patients, even to a wider variety of tumor therapies, the present application proposes an improvement to the beam shaper for neutron capture therapy. As one preference, is directed to improvements in beam shapers for accelerator boron neutron capture therapy.
Fig. 1 shows a beam shaper 10 for neutron capture therapy according to the present application, the beam shaper 10 comprising a beam inlet 11, a target 12, a retarder 13 adjacent to the target 12, a reflector 14 enclosed outside the retarder 13, and a beam outlet 17. Accelerator boron neutron capture therapy accelerates a proton beam with an accelerator to an energy sufficient to overcome the nuclear forces of the target material, with which the target material 12 is exposed7Li(p,n)7The Be nuclei react to produce neutrons (see fig. 2), the produced neutrons are decelerated by the retarder 13, and the scattered neutrons are reflected by the reflector 14 back onto the beam axis and exit the beam exit 17.
The manufacturing materials of the retarder 13 can be various, and the materials of the retarder 13 have great influence on the indexes of a neutron energy area, neutron beam flux and even neutron beam forward property, so that the retarder 13 can be replaced to solve the problem that different tumor conditions (including depth and type of position) cannot use the same medical equipment for neutron capture treatment.
The retarder 13 includes a base portion 131 and an extension portion 132, and the base portion 131 and the extension portion 132 are of a split structure. The split structure is such that the base portion 131 is located behind the target 12, and the extension portion 132 is attached behind the base portion 131. The base portion 131 may be replaceable or fixed. When the base portion 131 is replaceable, the base portion 131 and the extension portion 132 can be replaced, respectively; when the base portion 131 is fixed, only the extension portion 132 is replaced. Of course, the base portion 131 and the extension portion 132 may be integrally provided, and the entire retarder 13 may be replaced with another one to change the retarding capability of the retarder 13 for different tumor cases.
In the present embodiment, the base portion 131 and the extension portion 132 are used in a split design, and the base portion 131 is fixed. The base portion 131 of the retarder 13 is disposed behind the target 12 and fixed adjacent to the target 12, and the extension portion 132 is attached behind the base portion 131 and adjacent to the base portion 131. In the present embodiment, the extension portion 132 includes at least a first extension portion 133 and a second extension portion 134. The first expansion part 133 is adjacent to the rear of the base part 131, and the second expansion part 134 is adjacent to the rear of the first expansion part 133, so that the expansion part 132 forms a two-structure stacked type, and the first expansion part 133 and the second expansion part 134 can be replaced independently. It should be noted that, because there are many materials for making the retardation body 13, the extension portion 132 can be arranged in a stacked manner with more than two (three, four, five or more) structures, so as to change the retardation capability of the retardation body more finely, and achieve the requirement of more precise quality of the neutron beam, thereby improving the treatment effect for different tumors.
The following describes in detail how the extension portion 132 of the retarder 13 is replaced.
Fig. 3 is a schematic structural diagram of a first embodiment of the present application. The reflector 14 is provided with a guide groove 141, a slide rail 142 is provided in the guide groove 141, and the extension 13 is mounted in the guide groove 141, moved to the rear of the base 131 by the slide of the slide rail 142, and fixed adjacent to the base 131. The guide grooves 141 include at least a first guide groove 143 corresponding to the first expansion 133 and a second guide groove 144 corresponding to the second expansion 134. When the entire structure of the retarder 13 is a cylinder and the first extension 133 and the second extension 134 have the same structural size, the first extension 133 and the second extension 134, which are made of different materials, may be installed in the first guide groove 143 or the second guide groove 144 according to the quality requirement of the neutron beam to be obtained. That is, in this case, since the first extension 133 and the second extension 134 have the same size, there is no limitation on whether the first extension 133 or the second extension 134 is installed in the first guide groove 143 and the second guide groove 144, as long as the material of the extension 132 installed in the first guide groove 143 and the second guide groove 144 enables the quality of the neutron beam obtained after passing through the retarder 13 to meet the desired requirements. When the overall structure of the retarder 13 is a cylinder, or a cone, or a combination of a cylinder and a cone, and the first extension 133 and the second extension 134 have different structural sizes, the first extension 133 and the second extension 134, which are made of different materials, are selected according to the quality requirement of the neutron beam to be obtained, the first extension 133 can only be correspondingly installed in the first guide groove 143, and the second extension 134 can only be correspondingly installed in the second guide groove 144.
The reflector 14 further includes supplementary reflectors 145 disposed at both outer sides of the extension 132 and installed in the guide grooves 141. The supplementary reflector 145 may be integrally formed with the extension portion 132 and installed in the guide groove 141, or may be separately installed in the guide groove 141 after the extension portion 132 is installed in the guide groove 141. When the extension portion 132 is attached to the rear of the base portion 131 by the slide rail 142, the complementary reflector 145 and the reflector 14 surrounding the base portion 131 together reflect the scattered neutrons so that the scattered neutrons are reflected back to the neutron beam main axis, thereby increasing the beam intensity of the epithermal neutrons.
Fig. 4 is a schematic structural diagram of a second embodiment of the present application. The reflector 14 is provided with a rotating shaft 15 parallel to the center line of the base portion 131 of the retarder 13, and the rotating shaft 15 is provided with a dial 146 positioned behind the base portion 131 and rotatable relative to the base portion 131. The extension portion 132 is attached to the turntable 146, rotates around the rotation shaft 15 about the rotation axis to the rear of the base portion 131, and is fixed adjacent to the base portion 131. The dial 146 includes at least a first dial 147 corresponding to the first extension 133 and a second dial 148 corresponding to the second extension 134. When the overall structure of the retarder 13 is a cylinder and the first extension 133 and the second extension 134 have the same structural size, the first extension 133 and the second extension 134, which are made of different materials, may be mounted in the first rotating disk 147 or the second rotating disk 148 according to the quality requirement of the neutron beam to be obtained. In this case, since the first extension 133 and the second extension 134 have the same size, it is not required whether the first extension 133 or the second extension 134 is installed in the first rotating disk 147 and the second rotating disk 148 as long as the material of the extension 132 installed in the first rotating disk 147 and the second rotating disk 148 can make the quality of the neutron beam obtained after passing through the retarder 13 meet the desired requirements. When the overall structure of the retarder 13 is a cylinder, or a cone, or a combination of a cylinder and a cone, and the structural sizes of the first extension 133 and the second extension 134 are different, the first extension 133 and the second extension 134 made of different materials are selected according to the quality requirement of the neutron beam to be obtained, the first extension 133 can only be correspondingly installed in the first rotary table 147, and the second extension 134 can only be correspondingly installed in the second rotary table 148.
The reflector 14 further includes a supplementary reflector 145 'provided on the outer circumference of the extension 132, and the supplementary reflector 145' may be integrally formed with the extension 132 and then installed in the turntable 146, or may be separately installed in the turntable 146 after the extension 132 is installed in the turntable 146. When the extension portion 132 is rotatably mounted behind the base portion 131 around the rotation axis, the complementary reflector 145' reflects the scattered neutrons together with the reflector 14 surrounding the outside of the base portion 131 so that the scattered neutrons are reflected back to the main axis of the neutron beam, thereby increasing the beam intensity of the epithermal neutrons.
The retarder 13 is made of a material having a large fast neutron action section and a small epithermal neutron action section, and preferably, the retarder 13 is made of Al, Pb, Ti, Bi、C、D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3At least one of Al, Pb, Ti, Bi, C, and D, and the base 131 of the retarder 13 is made of2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3At least one or more of the first and second extensions 133 and 134 are made of Al, Pb, Ti, Bi, C, and D20、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3At least one or more of them. That is, in the present application, the materials of the first extension 133, the second extension 134, and the base portion 131 may be identical to each other or may be different from each other. The reflector 14 is made of a material having a strong neutron reflecting ability, and as a preferred embodiment, the reflector 14 is made of at least one of Pb or Ni.
The front end of the retarder 13 may be covered with a fast neutron filter (not shown), and the rear end of the retarder 13 may be provided with a thermal neutron absorber (not shown). A gap channel 18 is arranged between the retarder 13 and the reflector 14, an air channel 19 is arranged between the thermal neutron absorber and the beam outlet 17, and a radiation shield 16 capable of reducing the normal tissue dose in the non-irradiated area is arranged in the reflector 14. The gap channel 18 refers to an empty area easily passed by the neutron beam, which is not covered with a solid material, and the gap channel 18 may be configured as an air channel or a vacuum channel. The gap channel 18 is arranged to increase the flux of epithermal neutrons, and the air channel 19 is arranged to continuously guide neutrons deviated from the main axis of the neutron beam back to the main axis to increase the intensity of the epithermal neutron beam. The radiation shield 16 includes a photon shield 161 to shield the neutron beam from leaky photons and a neutron shield 162 to shield the neutron beam from leaky neutrons. The photon shield 161 may be integral or non-integral with the reflector 14 and the neutron shield 162 may be positioned adjacent the beam exit 17.
A proton beam enters from a beam inlet 11 and carries out nuclear reaction with a target material 12 to generate neutrons, the neutrons form a neutron beam, the neutron beam defines a beam main shaft, and the formed neutron beam firstly passes through a fast neutron filter to filter fast neutrons in the neutron beam so as to decelerate more fast neutrons; the neutron beam after passing through the fast neutron filter decelerates neutrons to a hyperthermic neutron energy region through the retarder 13, the thermal neutron absorber absorbs thermal neutrons in the neutron beam to avoid excessive dosage with shallow normal tissues during treatment, and the reflector 14 guides neutrons deviating from the beam main axis to improve the intensity of the hyperthermic neutron beam, so that the beam quality which best meets the treatment of the patient is obtained.
The fast neutron filter body is made of a material with a large fast neutron acting cross section, preferably, the fast neutron filter body is made of Fe, the thermal neutron absorber 15 is made of a material with a large thermal neutron acting cross section, and as a preferred embodiment, the thermal neutron absorber is made of 6L i, as a preferred material, the photon shield 161 is made of lead (Pb), and the neutron shield is made of Polyethylene (PE).
The beam integer 10 of this application neutron capture treatment only needs to select the retardance body of different materials to adjust the retardance ability of neutron according to the actual requirement of indexes such as tumour to beam neutron energy district, neutron beam flux, just can use same medical equipment to treat different patients, simple structure, and the suitability is strong.
The beam shaper for neutron capture therapy disclosed in the present application is not limited to the configurations described in the above embodiments and shown in the drawings. Obvious changes, substitutions or alterations of the materials, shapes and positions of the components in the invention are all within the scope of the invention as claimed.
Claims (9)
1. A beam shaper for neutron capture therapy, characterized by: the beam shaping body comprises a beam inlet, a target material, a retarder adjacent to the target material, a reflector and a beam outlet, the retarder is enclosed outside the retarder, a proton beam enters from the beam inlet and reacts with the target material to generate neutrons, the neutrons form a neutron beam, the neutrons are decelerated by the retarder, the reflector reflects scattered neutrons to a beam axis and then emits the neutrons from the beam outlet, the retarder can be replaced to adjust the retarding capacity of the retarder to the neutrons, the retarder comprises a base part positioned behind the target material and an expansion part positioned behind the base part and separated from the base part, the expansion part can be replaced by different materials according to the quality of the neutron beam required to be achieved, the expansion part at least comprises a first expansion part and a second expansion part, the first expansion part and the second expansion part can be replaced independently, and the base part, the first expansion part and the second expansion part can be made of Al, Pb, Ti, Bi, C, D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3Any one or more of them.
2. The beam shaper for neutron capture therapy of claim 1, wherein: the extensions can be individually replaced without changing the overall size of the beam shaper.
3. The beam shaper for neutron capture therapy of claim 1, wherein: the first expansion part is arranged behind the base part and is adjacent to the base part, and the second expansion part is arranged behind the first expansion part and is adjacent to the first expansion part.
4. The beam shaper for neutron capture therapy of claim 1, wherein: the first extension part and/or the second extension part made of different materials are/is replaced according to the quality of the neutron beam to be achieved.
5. The beam shaper for neutron capture therapy of claim 1, wherein: the base portion is adjacent to the rear of the target and fixed with the target, and the expansion portion is mounted on the rear of the base portion and adjacent to the base portion.
6. The beam shaper for neutron capture therapy of claim 4, wherein: the reflector further includes a supplementary reflector provided outside or on the outer periphery of the extension portion, and the supplementary reflector and the reflector surrounding the base portion reflect scattered neutrons together.
7. The beam shaper for neutron capture therapy of claim 6, wherein: the reflector is provided with a guide groove corresponding to the expansion part and extending to the rear part of the base part, the guide groove is provided with a slide rail, and the expansion part is arranged in the guide groove, moves to the rear part of the base part through the slide rail and is adjacent to the base part; the guide grooves at least comprise a first guide groove corresponding to the first expansion part and a second guide groove opposite to the second expansion part; when the first expansion part and the second expansion part have the same structure size and are made of different materials, the first expansion part and the second expansion part can be respectively installed in the first guide groove or the second guide groove; when the first extension part and the second extension part are different in structural size and different in material, the first extension part is installed in the first guide groove, the second extension part is installed in the second guide groove, the supplementary reflector is installed in the guide groove, and when the extension part is installed at the rear of the base part through the slide rail, the supplementary reflector surrounds the outer side of the extension part and reflects scattered neutrons together with the reflector surrounding the outer periphery of the base part.
8. The beam shaper for neutron capture therapy of claim 6, wherein: the reflector is provided with a rotating shaft, the rotating shaft is provided with a turntable which is positioned behind the base part and can rotate relative to the base part, and the expansion part is arranged in the turntable, rotates along with the turntable to move to the rear part of the base part and is adjacent to the base part; the rotating discs at least comprise a first rotating disc corresponding to the first expansion part and a second rotating disc corresponding to the second expansion part; when the first expansion part and the second expansion part have the same structure size and are made of different materials, the first expansion part and the second expansion part can be installed in the first rotary disc or the second rotary disc respectively; when the first extension part and the second extension part are different in structural size and different in material, the first extension part is installed in the first rotary table, the second extension part is installed in the second rotary table, the supplementary reflector is installed in the rotary table on the periphery of the extension part, and when the extension part is installed behind the base part in a rotating mode around the rotating shaft, the supplementary reflector surrounds the periphery of the extension part and reflects scattered neutrons together with the reflector surrounding the periphery of the base part.
9. The beam shaper for neutron capture therapy of claim 6, wherein: the reflector is made of at least one of Pb or Ni, and the supplementary reflector is made of the same material as the reflector.
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| CN201810275965.XA CN108355257B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
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| CN201510643065.2A CN106552323B (en) | 2015-09-30 | 2015-09-30 | Beam-shaping body for neutron capture treatment |
| CN201810275965.XA CN108355257B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
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| CN201810275069.3A Active CN108543233B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275965.XA Active CN108355257B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
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| CN109173083B (en) * | 2018-09-13 | 2023-09-15 | 国科中子医疗科技有限公司 | Neutron capture treatment system |
| ES2894548A1 (en) * | 2020-08-09 | 2022-02-14 | Univ Granada | Production device, moderation and forming of neutron beams for neutron capture therapy (Machine-translation by Google Translate, not legally binding) |
| CN112885498A (en) * | 2021-01-30 | 2021-06-01 | 散裂中子源科学中心 | Collimator used for BNCT and convenient for changing shape and size of neutron extraction pore channel |
| CN113724908A (en) * | 2021-08-11 | 2021-11-30 | 散裂中子源科学中心 | Thermal neutron beam shaping device |
| CN117877781A (en) * | 2022-10-10 | 2024-04-12 | 中硼(厦门)医疗器械有限公司 | Beam shaping body and neutron capture treatment system |
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| JP2008022920A (en) * | 2006-07-18 | 2008-02-07 | Hitachi Ltd | Medical device for boron neutron capture therapy |
| JP2014115122A (en) * | 2012-12-06 | 2014-06-26 | Mitsubishi Heavy Industries Mechatronics Systems Ltd | Neutron speed adjusting device and neutron generator |
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| NL7402505A (en) * | 1974-02-25 | 1975-08-27 | Philips Nv | NEUTRON THERAPY DEVICE. |
| US7394082B2 (en) * | 2006-05-01 | 2008-07-01 | Hitachi, Ltd. | Ion beam delivery equipment and an ion beam delivery method |
| CN200998534Y (en) * | 2006-05-18 | 2008-01-02 | 深圳市华科核医疗技术有限公司 | Irradiation device for medical application |
| WO2012090614A1 (en) * | 2010-12-27 | 2012-07-05 | 住友重機械工業株式会社 | Energy degrader and charged-particle irradiation system provided with same |
| JP5726644B2 (en) * | 2011-06-06 | 2015-06-03 | 住友重機械工業株式会社 | Energy degrader and charged particle beam irradiation system including the same |
| JP2013062193A (en) * | 2011-09-14 | 2013-04-04 | Sumitomo Heavy Ind Ltd | Neutron beam irradiation device |
| JP5996470B2 (en) * | 2013-03-29 | 2016-09-21 | 住友重機械工業株式会社 | Neutron capture therapy device |
| JP6042269B2 (en) * | 2013-05-22 | 2016-12-14 | 住友重機械工業株式会社 | Neutron capture therapy device and neutron beam measurement method |
| TWI532056B (en) * | 2013-10-15 | 2016-05-01 | 財團法人工業技術研究院 | Filter and neutron beam source including the same |
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| JP2008022920A (en) * | 2006-07-18 | 2008-02-07 | Hitachi Ltd | Medical device for boron neutron capture therapy |
| JP2014115122A (en) * | 2012-12-06 | 2014-06-26 | Mitsubishi Heavy Industries Mechatronics Systems Ltd | Neutron speed adjusting device and neutron generator |
Also Published As
| Publication number | Publication date |
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| CN108355257A (en) | 2018-08-03 |
| CN106552323A (en) | 2017-04-05 |
| CN108325095A (en) | 2018-07-27 |
| CN108325095B (en) | 2020-08-07 |
| CN108543233A (en) | 2018-09-18 |
| CN106552323B (en) | 2018-05-15 |
| CN108543233B (en) | 2020-08-07 |
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Application publication date: 20180803 Assignee: China Boron (Xiamen) Medical Devices Co., Ltd. Assignor: NEUBORON MEDTECH LTD. Contract record no.: X2019320000054 Denomination of invention: Beam shaping body for neutron capture therapy License type: Common License Record date: 20190910 |
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