CN108341089B

CN108341089B - Aseptic transmission device and packaging system under clean environment

Info

Publication number: CN108341089B
Application number: CN201710062702.6A
Authority: CN
Inventors: 龚燕斌; 卫晓峰
Original assignee: Suzhou Autocran Med Technology Co ltd
Current assignee: Suzhou Autocran Med Technology Co ltd
Priority date: 2017-01-24
Filing date: 2017-01-24
Publication date: 2021-10-01
Anticipated expiration: 2037-01-24
Also published as: CN108341089A

Abstract

The invention discloses an aseptic transmission device and a packaging system in a clean environment. The sterile butt joint valve is provided with a first valve and a second valve, and the first valve is arranged in the through hole of the first frame working table; the lifting mechanism and the rotating mechanism are used for driving the second valve to move towards or away from the first valve respectively and driving the second valve to rotate by a preset angle, and the rotating mechanism comprises a rotating body and a first driving assembly for driving the rotating body to rotate; the lifting mechanism is fixed on the rotating body. The packaging system includes an aseptic transfer device. Under the action of the lifting mechanism, the second valve is embedded into the first valve or taken out of the first valve; under the action of the rotating mechanism, the second valve is rotated by a required angle, and the second valve and the first valve are automatically butted or separated, so that the transmission efficiency of the transmission device is improved, and the biological tissues or organs in the second valve are always in a clean environment in the whole transmission process.

Description

Aseptic transmission device and packaging system under clean environment

Technical Field

The invention belongs to the technical field of transmission of biological tissues or organs, and particularly relates to an aseptic transmission device and a packaging system in a clean environment.

Background

With the continuous development of the fields of medical technology, biotechnology and the like, the demands for in vitro sterile transmission and packaging of biological tissues or organs in a clean environment are generated, a full-chain closed technical support needs to be provided for the sterile transmission and packaging of the biological tissues or organs in the clean environment through devices and equipment, and the technical support needs to be an intelligent automation and information whole-process traceable solution. For example, in order to treat the cause of disease during surgery, the organ needs to be stored in a clean environment outside the body for a period of time before replanting or transplanting, or the organ needs to be cultured outside the body in a laboratory in the field of genetic engineering, and then the organ enters an operating room for transplantation, and the like.

At present, when a human tissue or organ is transported aseptically or packaged in a clean environment, it is necessary to use an aseptic butt valve for transporting the biological tissue or organ, and most of the existing aseptic butt valves have a structure like the butt valve disclosed in chinese patent document CN203158274U, including a main valve, a slave valve, a safety plug, and a safety cap. The main valve comprises a main valve body and a main valve plate, and the main valve comprises a slave valve body and a slave valve plate. The main valve plate is arranged at the feed inlet of the main valve body, the slave valve plate is arranged at the discharge outlet of the slave valve body, and biological tissues or organs are placed in the inner cavity of the slave valve body. After the butt joint valve is locked, the main valve plate and the slave valve plate are tightly attached together, and after the butt joint valve is opened, the main valve plate and the slave valve plate synchronously rotate and open the top opening of the slave valve body.

In the use process of the butt joint valve with the structure, the initial main valve and the slave valve are mutually independent, the slave valve is arranged in the main valve in a manual mode, the main valve is tightly butted with the slave valve, the locking handle of the slave valve is rotated, the main valve plate and the slave valve plate rotate together, the main valve plate and the slave valve plate are integrally opened from the discharge hole of the slave valve body, then the slave valve body cavity is communicated with a clean environment, the biological tissue or organ and the box body are taken out from the slave valve cavity and put into the clean environment, after the transfer of the biological tissue or organ is completed, the slave valve is required to be taken out from the main valve, and the main valve plate and the slave valve plate are closed by the operating handle, so that the slave valve plate is horizontally sealed on the discharge hole of the slave valve body; the slave valve body is rotated in the reverse direction to disengage the slave valve from the master valve, and the slave valve is manually removed from the master valve to bring the master valve and the slave valve into the initial independent state.

Therefore, the main valve and the slave valve are butted or separated in a manual mode, so that the whole transmission device cannot realize automatic operation and has low working efficiency; meanwhile, when the manual mode is improper, the valve inner cavity is easily communicated with the outside, so that biological tissues or organs are polluted, and the storage period of the packaged biological tissues or organs is influenced.

Disclosure of Invention

Therefore, the technical problem to be solved by the present invention is that the first valve and the second valve of the docking valve in the prior art sterile transfer device cannot realize automatic docking or separation, resulting in low transfer efficiency and short storage period of biological tissues or organs.

To this end, the invention provides an aseptic transfer device comprising

A first frame having a work table;

a sterile docking valve having a first valve and a second valve, the first valve sealingly nested within a through-hole mounted in the countertop;

the lifting mechanism and the rotating mechanism are arranged below the working table surface and are used for respectively driving the second valve to move towards or away from the first valve and driving the second valve to rotate relative to the first valve by a required preset angle so as to enable the second valve to be in sealed butt joint with or separated from the first valve;

the rotating mechanism comprises a rotating body positioned below the working table surface and a first driving assembly for driving the rotating body to rotate; the lifting mechanism is fixed on one side surface of the rotating body facing the working table.

Preferably, in the sterile transfer device, the first driving assembly includes a first cylinder, and a rack connected to a telescopic shaft of the first cylinder; the surface of the rotating body facing the side of the rack is provided with a tooth surface meshed with the rack.

Further preferably, in the above sterile transfer device, the rotating body is a rotating disc, and the number of the central angles of the tooth surfaces of the rotating disc is the preset angle.

Preferably, the sterile transfer device further comprises a support body fixed on the top of the lifting mechanism, and a first guide structure guiding and detachably mounting the second valve on the support body.

Preferably, in the sterile transfer device, the first guide structure comprises a first plug-in connector formed on the top surface of the support body; a first groove which is formed on the bottom surface of the second valve and is inwards concave, and a limiting groove which is outwards protruded and is suitable for being sleeved on the first plug connector is formed in the first groove; the second valve can slide towards or away from the first plug connector, so that the limiting groove is sleeved on the first plug connector or separated from the first plug connector.

Further preferably, in the sterile transmission device, the first connector clip is a T-shaped plate, and correspondingly, the limiting groove is a T-shaped groove; the T-shaped groove is sleeved on the horizontal part of the T-shaped plate through the opening of the T-shaped groove.

Preferably, in the sterile transfer device, the first frame further includes a support table located below the working table, and at least two baffles connecting and opposing the support table and the working table; the support table surface is provided with a passage for the support body to pass through, and at least two baffles, the support table surface and the working table surface form a pick-and-place space for the second valve to slide into or out of the support body.

Further preferably, in the sterile transfer device, the first guide structure further includes at least one slide rail disposed on the support platform for sliding the second valve, and the slide rail extends along the length direction of the baffle plate from one end of the support platform to the edge of the channel; and/or

The support table is further provided with an arc limiting block, the arc surface of the arc limiting block is suitable for the outer wall surface of the second valve to abut against, and the position of the second valve sliding into the support body is limited.

Preferably, the sterile transfer device further comprises two sets of second guide structures arranged on the rotating body relatively, and the two sets of second guide structures are used for guiding the lifting mechanism to drive the second valve to make linear motion.

Further preferably, in the above sterile transfer device, each set of the second guiding structure comprises

The vertical plate is vertically arranged on the rotating body, is positioned on the same side as the lifting mechanism and is provided with a first through hole extending vertically;

the upright post is fixed on the bottom of the support body and extends towards the rotating body along the length direction of the first through hole;

and one end of the first guide piece is horizontally fixed on the upright post, and the other end of the first guide piece extends into the first through hole.

Preferably, the sterile transmission device further comprises a limiting mechanism arranged on the upright post and used for limiting the lifting height of the lifting mechanism.

Further preferably, in the above sterile transfer device, the limiting mechanism comprises

The limiting plate is fixed on the top of the vertical plate, and a first notch or a through hole for the upright post to pass through is formed in the limiting plate;

the fixing plate is fixed on the upright post and is positioned below the limiting plate;

the adjusting piece avoids the upright post from being installed on the fixed plate along the length direction of the first through hole, and the top of the adjusting piece is opposite to the bottom surface of the limiting plate.

Preferably, in the sterile transfer device, the first valve has a fixed valve body and a first movable valve cover, the fixed valve body has an annular inner cavity communicated with the outside, and the first movable valve cover is hermetically embedded in the annular inner cavity; the fixed valve body is embedded in the through hole of the working table top;

the second valve is provided with a movable valve body and a second movable valve cover, the movable valve body is provided with a top opening and a second inner cavity, and the second movable valve cover is hermetically embedded and installed in the top opening of the movable valve body;

the rotating mechanism drives the movable valve body to rotate by a preset angle, so that the movable valve body is separated from or matched with the second movable valve cover and is respectively matched with or separated from the fixed valve body and the first movable valve cover.

Further preferably, in the sterile transfer device, the sterile docking valve further includes an automatic cover opening mechanism disposed on the fixed valve body, and the automatic cover opening mechanism is configured to drive the first movable valve cover to perform a turning motion to open or close the second movable valve cover when the first movable valve cover is matched with the second movable valve cover;

the cover opening mechanism comprises a second driving assembly and a transition piece driven by the second driving assembly, wherein the transition piece is back to one end of the second driving assembly and is connected with the first movable valve cover, and the second driving assembly drives the transition piece to rotate so as to drive the first movable valve cover to perform turnover motion.

Preferably, in the sterile transfer device, the sterile docking valve further comprises an adjusting mechanism for lifting or restraining the end of the first movable valve cover away from the second driving assembly from or in the annular inner cavity.

Further preferably, in the above sterile transfer device, the adjusting mechanism comprises

The limiting assembly is movably arranged on the fixed valve body;

one end of the second plug connector is fixed on the first movable valve cover;

under the action of the limiting component, the other end of the second plug connector can be inserted into the limiting component to be limited or separated from the limiting component and is lapped on the limiting component.

More preferably, in the above sterile transfer device, the position limiting component comprises

The sliding body is arranged on the fixed valve body in a sliding manner along the radial direction of the annular inner cavity, and a second concave groove which is inwards sunken is formed in the surface of one side, facing the annular inner cavity, of the sliding body;

the elastic piece is arranged at one end of the sliding body, which is back to the second plug connector, and applies acting force towards the direction of the second plug connector to the sliding body;

the driving piece is arranged on the fixed valve body in a sliding mode, the sliding direction of the driving piece is perpendicular to the sliding direction of the sliding body, one end of the driving piece can be inserted into or withdrawn from the sliding body in a sliding mode, the space between the sliding body and the second plug connector forces the sliding body to move towards and away from the direction of the second plug connector and enables the other end of the second plug connector to be in lap joint with the sliding body.

Preferably, the sterile transfer device further comprises a second guide member fixed on the fixed valve body and extending outward in the radial direction of the annular cavity, the second guide member is embedded in the sliding body, and the sliding body can slide linearly on the second guide member.

The invention also provides a packaging system under clean environment, which comprises

The second rack is provided with a horizontal table top and partition plates arranged on the periphery of the horizontal table top, an installation cavity with an opening at the top is formed by the partition plates and the top surface of the horizontal table top in a surrounding mode, and a clean environment is formed in the installation cavity;

the sterile transfer device is hermetically installed at one end of the installation cavity, the working table is flush with the horizontal table, and the first frame is located in a space enclosed between the second frame and the bottom surface of the horizontal table and used for conveying biological tissues or organs placed in the second valve into the installation cavity;

at least one heat sealing mechanism arranged on the horizontal table top and used for heat sealing a first cover body made of a required material on the top opening of the box body for containing the biological tissues or organs;

and the finished product output device is arranged on the horizontal table top at the other end of the second rack and is used for outputting the packaged finished product from the clean installation cavity.

Preferably, the packaging system in a clean environment further comprises a packaging mechanism arranged on the horizontal table and located between the heat sealing mechanism and the finished product output device, and the packaging mechanism is used for packaging an outer bag made of a required material outside the box body.

Further preferably, in the packaging system under clean environment, the mounting cavity is U-shaped;

the sterile transmission device and the finished product output device are respectively positioned at two ends of the U shape.

The technical scheme provided by the invention has the following advantages:

1. the invention provides an aseptic transmission device which comprises a first machine frame, an aseptic butt joint valve, a lifting mechanism and a rotating mechanism. Wherein, the first frame is provided with a working table; the sterile docking valve is provided with a first valve and a second valve, and the first valve is embedded in the through hole of the working table in a sealing mode; the lifting mechanism and the rotating mechanism are arranged below the working table surface and are used for respectively driving the second valve to move towards or away from the first valve and driving the second valve to rotate relative to the first valve by a required preset angle so as to enable the second valve to be in sealed butt joint with or separated from the first valve; the rotating mechanism comprises a rotating body positioned below the working table surface and a first driving assembly for driving the rotating body to rotate; the lifting mechanism is fixed on one side surface of the rotating body facing the working table.

The sterile transmission device with the structure has the advantages that the first valve and the second valve are initially in an independent state, and when the biological tissues or organs in the second valve need to be transferred into the clean environment of the packaging system, the second valve is driven by the lifting mechanism to move towards the first valve, so that the second valve is embedded into the first valve; under the drive of the rotating mechanism, the second valve rotates by a required angle relative to the first valve, so that the automatic butt joint process of the second valve and the first valve is realized; when the second valve needs to be taken out of the first valve, the rotating mechanism drives the second valve to rotate reversely, so that the second valve is separated from the first valve, the second valve moves towards the direction far away from the first valve under the driving of the lifting mechanism, the automatic separation process of the second valve and the first valve is realized, the second valve is taken out of the first valve and then returns to the initial independent state, the transmission efficiency of the transmission device is improved, and the biological tissues or organs in the second valve are always in a clean environment in the whole transmission process.

2. The sterile transfer device further comprises a support body fixed on the top of the lifting mechanism, and a first guide structure guiding and detachably mounting the second valve on the support body. The provision of the first guide formation facilitates quick location and mounting of the second valve on the support body.

3. The sterile transmission device further comprises two sets of second guide structures which are oppositely arranged on the rotating body and used for guiding the lifting mechanism to drive the second valve to do linear motion, and guiding the second valve to be embedded into the first valve or withdrawn from the first valve in a right-facing mode, so that the second valve and the first valve can be conveniently butted or separated. .

4. The sterile transmission device provided by the invention is characterized in that the sterile butt joint valve further comprises an automatic cover opening mechanism arranged on the fixed valve body, and the automatic cover opening mechanism is used for driving the first movable valve cover to turn over to open or close the second movable valve cover when the first movable valve cover is matched with the second movable valve cover; the cover opening mechanism comprises a second driving assembly and a transition piece driven by the second driving assembly, wherein the transition piece is back to one end of the second driving assembly and is connected with the first movable valve cover, and the second driving assembly drives the transition piece to rotate so as to drive the first movable valve cover to perform turnover motion. The automatic mechanism that uncaps sets up, first valve and second butt joint back for synchronous upset motion is done with second movable valve lid to first movable valve lid, realizes opening or closing of the automation of second movable valve lid, thereby makes transmission device's whole transportation process realize automaticly, ensures that biological tissue or organ in the second valve are in clean environment always in the transfer process, can not be polluted by external environment, and then prolongs the off-the-shelf storage cycle of biological tissue or organ packing back.

5. The sterile transfer device provided by the invention is characterized in that the sterile docking valve further comprises an adjusting mechanism for lifting or limiting one end of the first movable valve cover, which is far away from the second driving assembly, from or in the annular inner cavity. When the second movable valve cover needs to be opened, the adjusting mechanism firstly relieves the limitation on the first movable valve cover and lifts one end of the first movable valve cover, which is far away from the driving assembly, so that the annular inner cavity is communicated with a clean environment in a packaging system, the force required by the driving piece for driving the transition piece to rotate is reduced, and the second movable valve cover is convenient to open; when the second movable valve cover needs to be closed, the first movable valve cover and the second movable valve cover both rotate reversely to be embedded into the annular inner cavity, and then the first movable valve cover and the second movable valve cover are limited by the adjusting mechanism, so that the first movable valve cover and the second movable valve cover are ensured to be located in the annular inner cavity.

6. The invention provides an aseptic transmission device, wherein an adjusting mechanism comprises a limiting component and a second plug connector, and the limiting component is movably arranged on a fixed valve body; one end of the second plug connector is fixed on the first movable valve cover; under the action of the limiting component, the other end of the second plug connector can be inserted into the limiting component to be limited or separated from the limiting component and is lapped on the limiting component. Through the slip of spacing subassembly, change the position of spacing subassembly for the second plug connector, realize that the other end of second plug connector inserts in the spacing subassembly or breaks away from spacing subassembly to the effect of realization to first movable valve gap restriction or raising is raised and is convenient for open first movable valve gap, releases the vacuum of the sealed department of first movable valve gap and second movable valve gap.

7. The sterile transmission device further comprises a second guide piece which is fixed on the fixed valve body and extends outwards along the radial direction of the annular inner cavity, the second guide piece is embedded into the sliding body, and the sliding body can slide linearly on the second guide piece. The setting of second guide, the guide sliding body is the straight line and slides on the second guide, and when the sliding body motion of being convenient for, in inserting the sliding body with the other end of second plug connector, perhaps from the roll-off in the sliding body, the dislocation phenomenon prevents to appear.

8. The packaging system in a clean environment comprises a second machine frame, the sterile transmission device, at least one heat sealing mechanism and a finished product output device. The second rack is provided with a horizontal table top and partition plates arranged on the periphery of the horizontal table top, an installation cavity with an opening at the top is formed by the partition plates and the top surface of the horizontal table top in a surrounding mode, and a clean environment is formed in the installation cavity; the sterile transmission device is hermetically installed at one end of the installation cavity, the working table top is flush with the horizontal table top, and the first rack is located in a space enclosed between the second rack and the bottom surface of the horizontal table top and used for conveying biological tissues or organs placed in the second valve into the installation cavity; at least one heat sealing mechanism is arranged on the horizontal table top and used for heat sealing a first cover body made of required materials on the top opening of the box body for containing the biological tissues or organs; and the finished product output device is arranged on the horizontal table top at the other end of the second rack and is used for outputting the packaged finished product from the clean installation cavity.

The packaging system with the structure adopts the sterile transmission device, and the sterile transmission device realizes the automatic butt joint or separation process of the second valve and the first valve in the butt joint valve under the coordination of the lifting mechanism and the rotating mechanism, so that the feeding efficiency of the packaging system is improved, the biological tissues or organs in the second valve are always in a clean environment in the transmission process, and the storage period of finished products formed in the subsequent packaging process of the biological tissues or organs is long.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

Fig. 1 is a first schematic structural diagram of an aseptic transfer device provided in embodiment 1 of the present invention;

fig. 2 is a schematic structural diagram ii of the sterile transfer device provided in embodiment 1 of the present invention;

fig. 3 is a schematic structural view of the sterile transfer device provided in embodiment 1 of the present invention, with the first valve, the second valve, the lid opening mechanism, the adjustment mechanism, and the buffer assembly removed;

fig. 4 is an assembly view of the rotating mechanism, the first driving assembly, the second guiding structure and the lifting mechanism in the sterile transmission device provided in embodiment 1 of the present invention;

fig. 5 is a schematic view of an assembly of a stop mechanism and a column of a second guide structure in the sterile transmission device provided in embodiment 1 of the present invention;

fig. 6 is a schematic assembly view of the first valve, the second valve, the cap opening mechanism, the adjusting mechanism and the buffer assembly in the sterile transfer device provided in embodiment 1 of the present invention;

FIG. 7 is an exploded schematic view of the adjustment mechanism of FIG. 6;

FIG. 8 is a schematic view of the second connector of the adjustment mechanism of FIG. 7;

FIG. 9 is an exploded view of the damper assembly of FIG. 6;

fig. 10 is a schematic structural view of the sterile transfer device provided in embodiment 1 of the present invention after the first valve and the second valve are assembled (the second movable valve cover is in a closed state);

FIG. 11 is a schematic view of the first valve of FIG. 10;

FIG. 12 is a schematic structural view of the second valve of FIG. 10;

FIG. 13 is a schematic illustration of the fixed valve body of the first valve of FIG. 11;

FIG. 14 is a schematic illustration of the construction of the first movable valve cover of the first valve of FIG. 11;

FIG. 15 is a schematic view of the movable valve body of the second valve of FIG. 12;

FIG. 16 is a schematic illustration of the construction of the second movable valve cover of the second valve of FIG. 12;

description of reference numerals:

1-a first valve; 11-fixing the valve body; 111-a first outer edge; 112-a first recessed region; 113-an annular lumen; 12-a first movable valve cover; 121-a sixth outer edge;

2-a second valve; 21-a movable valve body; 211-a second outer edge; 212-a third outer edge; 213-a second recessed region; 214-a first groove; 215-a limiting groove; 22-a second movable valve cover; 221-fourth outer edge; 222-a fifth outer edge; 223-a third recessed region; 224-a flange;

3-a cover opening mechanism; 31-a second drive assembly; 311, a motor; 312 — a first gear; 32-a transition piece;

41-a first support; 42-connecting blocks;

5-an adjusting mechanism; 51-a limit component; 511-a sliding body; 5111-a second groove; 5112-second chamfer; 512-an elastic member; 513 — a driving member;

52-a second plug connector; 521-a first chamfer angle; 522-boss; 523-first horizontal section; 524-a second horizontal section;

6, fixing blocks;

7-a second guide;

8-a buffer component; 81-a second support; 811-a chute; 82-a fixed seat; 83-a spacing pin;

9-a lifting mechanism;

10-a rotating mechanism; 101-a rotating body; 102-a first cylinder; 103-a rack; 104-a transition gear;

13-a support; 141-a first plug-in unit; 15-a second guiding structure; 151-vertical plate; 1511-first via; 152-upright column; 153-a first guide; 161-limiting plate; 162-a fixed plate; 163-bolt assembly; 17-a work table; 181-supporting a table top; 182-a mounting seat; 183-support column; 184-a slide bar; 185-baffle.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

Example 1

The present embodiment provides an aseptic transfer device, as shown in fig. 1 to 16, including a first frame, an aseptic butt valve, a lifting mechanism 9, a rotating mechanism 10, a supporting body 13, a first guiding structure, two sets of second guiding structures 15, and a limiting mechanism.

As shown in fig. 1-3, the first frame includes a work table 17, a support table 181, two baffles 185, a mounting seat 182, and a support post 183. The supporting table 181 is arranged below the working table 17, the mounting seat 182 is arranged below the supporting table 181, the two baffles 185 are arranged between the working table 17 and the supporting table 181 and connect the working table 17 with the supporting table 181, and the supporting column 183 connects the mounting seat 182 with the supporting table 181. Wherein, a channel for the support body 13 to pass through is opened on the support table 181, and a pick-and-place space for the second valve 2 to slide into the support body 13 (mentioned below) or slide out from the support body 13 is enclosed between the two baffles 185, the support table 181 and the working table 17.

As shown in fig. 10, 11, 13 and 14, the aseptic docking valve includes a first valve 1 and a second valve 2. Wherein the first valve 1 has a fixed valve body 11, the fixed valve body 11 has an annular inner cavity 113 communicating with the outside, and a first movable valve cover 12 fitted in the annular inner cavity 113. As shown in fig. 12, 15 and 16, the second valve 2 has a movable valve body 21, the movable valve body 21 having a top opening and a second inner cavity, and a second movable valve cover 22 sealingly mounted in the top opening of the movable valve body 21. Wherein, the fixed valve body 11 is embedded in the through hole of the working table 17 in a sealing way, and a required gap is reserved between the supporting body 13 and the fixed valve body 11.

The lifting mechanism 9 and the rotating mechanism 10 are used for respectively driving the second valve 2 to do telescopic motion towards or away from the annular inner cavity 113, so that the second valve 2 is hermetically embedded and installed in the annular inner cavity 113 and is positioned below the first movable valve cover 12; and the movable valve body is driven to rotate by a required preset angle, so that the movable valve body 21 is separated from or matched with the second movable valve cover 22 and is respectively matched with or separated from the fixed valve body 11 and the first movable valve cover 12, and automatic butt joint or separation of the second valve 2 and the first valve 1 is realized.

Specifically, as shown in fig. 3 and 4, the lifting mechanism 9 and the rotating mechanism 10 are both disposed below the work table 17, the rotating mechanism 10 is fixed on the mounting seat 182, the lifting mechanism is preferably a second air cylinder, and the rotating mechanism 10 includes a rotating body 101, such as a turntable, located below the work table 17 and a first driving assembly for driving the rotating body 101 to rotate; the second cylinder is provided on a side surface of the rotating body 101 facing the table surface 17. As shown in fig. 2, the first driving assembly includes a first cylinder 102, a rack 103 connected to an expansion shaft of the first cylinder 102; the surface of the turntable facing the rack 103 has a tooth surface that engages with the rack 103, and the tooth surface has a central angle of a predetermined degree.

For example, the preset angle is 60 degrees, and the preset angle is an angle that the movable valve body 21 rotates when the movable valve body 21 is engaged with the fixed valve body 11. When the movable valve body 21 rotates, the movable valve body 21 rotates to another angle smaller than the preset angle, for example, 45 degrees, at this time, the movable valve body 21 is separated from the second movable valve cover 22, the second movable valve cover 22 is just matched with the first movable valve cover 12, but the movable valve body 21 is not matched with the fixed valve body 11. Further, a transition gear 104 is arranged between the rack 103 and the turntable.

As shown in fig. 1 to 3, a support body 13 is provided on top of the lifting mechanism 9, and a first guide structure is used to guide and detachably mount the second valve 2 on the support body 13.

As shown in fig. 2 and 6, the first guiding structure includes a first plug 141 and a limiting groove 215, the first plug 141 is a T-shaped plate formed on the top surface of the supporting body 13, and the vertical portion of the T-shaped plate is fixed on the supporting body 13; the bottom surface of the movable valve body 21 is formed with an inward sunken first groove 214, the limiting groove 215 is a T-shaped groove which is formed in the first groove 214 and protrudes outwards, the T-shaped groove is sleeved on the horizontal part of a T-shaped plate through the opening of the T-shaped groove, so that the movable valve body 21 in the second valve 2 is installed on the support body 13, and the T-shaped structure is designed to facilitate the whole second valve 2 to slide in and be quickly positioned and installed on the support body 13 or be taken down from the support body 13.

As shown in fig. 4, the two sets of second guide structures 15 are oppositely arranged on the turntable, the lifting mechanism 9 is located between the two sets of second guide structures 15, each set of second guide structure 15 includes a vertical plate 151 arranged on the turntable, and a first through hole 1511 extending vertically is formed in the vertical plate 151; fix on the bottom of support body 13 and along the stand 152 that first through-hole 1511 length direction extends towards the rotator to and one end level is fixed on stand 152, the other end stretches into first guide part 153 in first through-hole 1511, for example the connecting rod, one of the end of stretching into in first through-hole 1511 of connecting rod is provided with spacing gyro wheel, when elevating system 9 drive support body 13 was elevating movement, do linear motion in first through-hole 1511 through the guide first guide part 153, make support body 13 drive the second valve 2 of installing on it do linear elevating movement, be convenient for just to imbed in the annular inner chamber 113 of first valve 1 with second valve 2. The arrangement of the two sets of second guiding structures 15 enables the supporting body 13 to do linear lifting movement more stably.

As shown in fig. 4 and 5, the limiting mechanism includes a limiting plate 161 fixed on the top of the vertical plate 151, and the limiting plate 161 is provided with a first gap or through hole for the upright 152 to pass through; a fixing plate 162 fixed on the column 152 and located below the limit plate 161, and an adjusting member 163 mounted on the fixing plate 162 along the length direction of the first through hole 1511, preferably, the adjusting member 163 is a bolt assembly in which a nut is located below the bottom of the fixing plate 162, the length of the bolt located above the top of the fixing plate 162 is adjusted by changing the locking position of the nut on the bolt, and when the bolt assembly moves upward along with the column 152, when the top of the bolt abuts against the limit plate 161, the height of the support body 13 rising is limited. The limiting mechanisms correspond to the second guiding structures 15 one by one, and further the supporting body 13 can do stable linear motion.

As shown in fig. 3, the first guiding structure further includes two sliding rails, such as sliding bars 184, disposed on the supporting table 181, the sliding bars 184 extend from one end of the supporting table 181 to the edge of the channel on the supporting body 13 along the length direction of the baffle 185, the two sliding bars 184 correspond to the first groove 214 on the bottom of the movable valve body 21, and when the movable valve body 21 slides on the two sliding bars 184, the limiting groove 215 is located just between the two sliding bars 184, so that the limiting groove 215 on the bottom of the movable valve body 21 is better slid into and sleeved on the first plug 141.

Simultaneously, still be provided with the arc stopper on supporting mesa 181, the cambered surface of arc stopper is suitable for the outer wall of movable valve body 21 to lean on, and when being convenient for movable valve body 21 slided into on supporter 13 through draw runner 184, it is spacing to the position that movable valve body 21 slided into on supporter 13, further realizes installing movable valve body 21 on first plug connector 141 fast.

As shown in fig. 6, the aseptic docking valve is further provided with a cap opening mechanism 3 and an adjusting mechanism 5, wherein the cap opening mechanism 3 is used for driving the second movable valve cap 22 to perform a turning motion to open or close the second movable valve cap 22 when the first movable valve cap 12 is matched with the second movable valve cap 22.

Specifically, as shown in fig. 6, the lid opening mechanism 3 includes a second driving assembly 31 and a transition piece 32, wherein the second driving assembly 31 includes a motor 311, a first gear 312 fixedly sleeved on a power output shaft of the motor 311; the transition piece 32 is a second gear, such as a sector gear, which is engaged with the first gear 312, one end of the sector gear is hinged to the fixed valve body 11 through a fixing component, and one end face with teeth is engaged with the first gear 312, when the rotating motor 311 drives the first gear 312 to rotate, the first gear 312 drives the sector gear to rotate and drives the first movable valve cover 12 and the second movable valve cover 22 to integrally perform a turning motion, so as to open or close the second movable valve cover 22 on the top opening of the movable valve body 21.

As shown in fig. 6, the fixing assembly includes a support fixed on the fixed valve body 11, and a connecting block 42, a rotating shaft disposed between two plates of the support, one end of the sector gear is hinged on the rotating shaft, one end of the connecting block 42 is connected to the sector gear, and the other end is connected to the first movable valve cover 12.

As shown in fig. 6, the adjusting mechanism 5 and the lid opening mechanism 3 are symmetrically distributed on the circumference of the fixed valve body 11, and the adjusting mechanism 5 includes a limit component 51 and a second plug 52. As shown in fig. 7 and 8, the second connector 52 is preferably a zigzag-shaped first plate, a zigzag-shaped lower first horizontal portion 523 is fixed to the first movable valve cover 12, and an upper second horizontal portion 524 is inserted into a second groove 5111 (mentioned below) of the sliding body 511. The second horizontal portion 524 has a first boss 522 protruding downward on a bottom surface thereof, and an end surface of the first boss 522 facing the driving member 513 has a first chamfer 521; the first chamfer 521 is an inwardly sloping surface.

As shown in fig. 7, the position limiting assembly 51 includes a sliding body 511, a driving member 513 and an elastic member 512. The elastic member 512 is preferably a first spring, the sliding body 511 is preferably a second plate, and the driving member 513 is preferably a third plate. The second plate is slidably disposed on the fixed valve body 11 along the radial direction of the annular inner cavity 113, and a side surface of the second plate facing the annular inner cavity 113 is provided with a second groove 5111 which is recessed inwards, an end surface of the second plate facing the driving member 513 is provided with a second chamfer 5112 which is inclined inwards, and an open end surface of the second groove 5111 of the second plate abuts against an end surface of the first boss 522, so that a space for the driving member 513 to be inserted is defined between the first chamfer 521 and the second chamfer 5112. The second panel slides in a direction perpendicular to the sliding direction of the third panel, the second panel sliding radially toward or away from the plug 52.

The longitudinal section of the driving member 513 is preferably an L-shaped plate, one end of a third plate is disposed on the cylinder, and the other end of the third plate can be slidably inserted into a gap defined between the first chamfer 521 and the second chamfer 5112 under the driving of the cylinder, so as to apply an acting force to the second plate, which moves away from the first plate, to force the second plate to move away from the first plate, and to make the bottom surface of the second horizontal portion 524 overlap the third plate; or, the second plate retreats from the gap enclosed between the first tangent angle 521 and the second tangent angle 5112, and the acting force on the second plate is cancelled. The two chamfered corners facilitate the insertion of one end of the driving member 513 into the gap between the sliding member 511 and the second plug member 52.

As shown in fig. 7, the valve further includes a fixing block 6 fixed on the fixing valve body 11, a first spring is disposed between the second plate and the fixing block 6, and the first spring applies a force to the second plate in a direction toward the first plate to force the second horizontal portion 524 to be inserted into the second groove 5111. That is, the elastic element 512 cooperates with the driving element 513 to make the sliding body 511 perform a reciprocating motion, so that the second horizontal portion 524 of the second plug-in connector 52 is inserted into the second groove 5111, so as to limit the first movable valve cover 12 in the annular inner cavity 113, or withdraw from the second groove 5111 and overlap on a third plate, so as to lift the first movable valve cover 12, and facilitate the motor 311311 to drive the first movable valve cover 12 to perform a turning motion.

As shown in fig. 6, the fixed valve body 11 is further provided with an installation plate, the sliding body 511 is arranged on the installation plate, the second guiding element 7 is arranged on the installation plate along the radial direction of the annular inner cavity 113, and the bottom of the sliding body 511 is provided with a second notch suitable for the second guiding element 7 to be inserted; the fixing block 6 is also mounted on the mounting plate, and the bottom thereof also has a second notch adapted to be inserted by the second guiding element 7, so that the sliding body 511 performs a reciprocating linear motion on the second guiding element 7 under the action of the driving element 513 and the elastic element 512. Preferably, the second guide 7 has a trapezoidal longitudinal cross-sectional shape, the shorter side of the trapezoid being fixed to the mounting plate and the longer side of the trapezoid being embedded in the second notch.

As shown in fig. 9, the cushion assembly 8 includes a second seat 81 disposed on the fixed valve body 11, and a fixed seat 82 fixed on the first movable valve cover 12, wherein a sliding groove 811 facing the fixed seat 82 is formed on a top surface of the second seat 81, a blind hole extending vertically is formed in a bottom of the sliding groove 811, and a second spring is installed in the blind hole; correspondingly, a corresponding hole is formed in one side, facing the sliding groove 811, of the fixing seat 82, the limit pin 83 penetrates through the hole, one end of the limit pin 83 is located in the hole of the fixing seat 82, and the other end of the limit pin extends into the sliding groove 811 and presses the top of the second spring.

When the second movable valve cover 22 needs to be opened, the limiting pin 83 and the fixing seat 82 move along with the first movable valve cover 12, when the second movable valve cover 22 needs to be closed, the limiting pin 83 rotates along with the first movable valve cover 12 and is located in the sliding groove 811 and pressed on the second spring, the second spring exerts buffering acting force on the limiting pin 83, and the first movable valve cover 12 and the second movable valve cover 22 are prevented from impacting the fixed valve body 11 when rotating downwards integrally.

For the above-mentioned rotating mechanism to drive the movable valve cover to rotate by the required preset angle, so that the movable valve body 21 is disengaged or engaged with the second movable valve cover 22 and is engaged or disengaged with the fixed valve body 11 and the first movable valve cover 12, respectively.

As shown in fig. 10, 11 and 13, six first outer edges 111 are arranged on the circumferential inner wall surface of the fixed valve body 11 at intervals, a first recessed area 112 is formed between two adjacent first outer edges 111, and correspondingly, as shown in fig. 15, six second outer edges 211 are arranged on the circumferential outer wall surface of the movable valve body 21 at intervals and uniformly; the arc length of the second outer rim 211 is less than the arc length of the first recessed area 112.

The movable valve body 21 is installed in the annular inner cavity 113 of the fixed valve body 11 through the lifting mechanism 9, the second outer edge 211 of the movable valve body 21 is firstly lapped on the first outer edge 111 of the fixed valve body 11 in a one-to-one correspondence manner, when the lifting mechanism 9, the supporting body 13 and the movable valve body 21 are driven to rotate in the horizontal direction through the turntable, the second outer edge 211 is respectively embedded into a first recessed area 112, a first limiting hole is formed in the fixed valve body 11, the limiting part is inserted into the first limiting hole and extends into the first recessed area 112, the limiting part is matched with a limiting block arranged in a second recessed area of the fixed valve body 11 to limit the rotating angle of the movable valve body 21, for example, the rotating angle is 60 degrees, and the second outer edge 211 is limited in the first recessed area 112, so that the movable valve body 21 and the fixed valve body 11 are matched into a whole. When the movable valve body 21 rotates reversely, the second outer edge 211 can be disengaged from the first recessed area 112 again and is overlapped on the first outer edge 111, so that the matching relationship between the movable valve body 21 and the fixed valve body 11 is released.

Similarly, six third outer edges 212 are also distributed on the circumference of the inner wall surface of the movable valve body 21, a second recessed area 213 is formed between every two adjacent third outer edges 212, six fourth outer edges 221 are uniformly distributed on the circumferential outer side wall surface of the second movable valve cover 22, and the arc length of each fourth outer edge 221 is smaller than that of the second recessed area 213. Initially, the fourth outer rim 221 is located in the second recessed area 213, and the movable valve body 21 is in sealing engagement with the second movable valve cover 22 to ensure a clean environment inside the movable valve body 21, for example, by a sealing ring or sealant, or a sealing strip, etc.

Similarly, the top of the second movable valve cover 22 has a circumferential flange 224 extending upward, six fifth outer rims 222 are formed on the inner wall surface of the circumferential flange 224, and a third recessed area 223 is formed between two adjacent fifth outer rims 222. Correspondingly, six sixth outer edges 121 are formed on the circumferential outer side wall surface of the first movable valve cover 12, the arc length of the sixth outer edges 121 is smaller than that of the third recessed area 223, and when the second valve 22 is installed in the annular inner cavity 113 of the first valve 1, the sixth outer edges 121 are firstly overlapped on one fifth outer edge 222 respectively. When the second movable valve cover 22 rotates along with the movable valve body 21, when the second movable valve cover 22 rotates to a desired angle, for example, 45 °, at this time, the sixth outer edge 121 is just located in the third recessed area 223, the first movable valve cover 12 is provided with a second limiting hole, a limiting member is inserted into the second limiting hole, the bottom of the limiting member extends into the third recessed area 223, the second movable valve cover 22 is limited along with the rotation angle of the movable valve body 21, so that the second movable valve cover 22 is matched with the first movable valve cover 12, at this time, the movable valve body 21 continues to rotate, but the second movable valve cover 22 is separated from the movable valve body 21. Conversely, when the movable valve body 21 rotates in the reverse direction, the first movable valve cover 12 can be disengaged from the second movable valve cover 22 and can be engaged with the movable valve body 21 again.

In the sterile transfer device of this embodiment, the first valve 1 and the second valve 2 are initially in an independent state, the fourth outer edge of the second movable valve cover 22 in the second valve 2 is embedded in the second recessed area, and the flange overlaps the third outer edge.

When biological tissues or organs in the second valve 2 are required to be transferred to a clean environment in the packaging system, the first groove 214 at the bottom of the second valve 2 is placed on the two slide bars 184, and slides to enable the limiting groove 215 to be sleeved on the T-shaped plate, and when the outer wall surface of the movable valve body 21 abuts against the arc-shaped limiting block, the movable valve body 21 is exactly aligned with the first plug connector 141.

The rotating mechanism 10 is firstly opened and then the lifting mechanism 9 is opened, so that the second valve 2 is integrally embedded into the annular inner cavity 113 of the first valve 1, when the top of the bolt on the fixing plate 162 abuts against the limiting plate 161, the rising height of the second valve 2 just reaches the preset height, the lifting mechanism stops working, and the second outer edge of the outer wall surface of the movable valve body 21 is respectively overlapped on the first outer edge. The rotating mechanism 10 drives the movable valve body 21 to rotate again, at this time, the second valve 2 rotates in the annular inner cavity 113 integrally to rotate to a first required angle, for example, 45 degrees, at this time, the sixth outer edge of the first movable valve cover 12 is just located in the third recessed area of the second movable valve cover 22, the second movable valve cover 22 is prevented from rotating along with the movable valve body 21 by the limiting member on the second limiting hole, when the movable valve body 21 continues to rotate, the fourth outer edge is separated from the second recessed area, so that the second movable valve cover 22 is separated from the movable valve body 21, and the second movable valve cover 22 and the first movable valve cover 12 form a first matching body.

Secondly, the movable valve body 21 continues to rotate, for example, when the movable valve body 21 rotates by 60 degrees, the second outer edge of the movable valve body 21 is just located in the first recessed area, and the limiting member in the first limiting hole limits the rotation of the movable valve body 21, so that the movable valve body 21 is matched with the fixed valve body 11 to form a second matching body.

Then, the cylinder drives the third plate to move towards the gap between the second plate and the first plate, so that one end of the third plate is inserted into the gap and drives the second plate to move towards the direction far away from the first plate, and the third plate is abutted against the slope surface of the first plate to lift the first plate, and the annular inner cavity 113 is communicated with the external clean environment. And then the motor 311 is started, the motor 311 drives the first gear 312 to drive the sector gear to rotate, the sector gear drives the first matching body to upwards turn by taking the rotating shaft of the first support 41 as a fulcrum through driving the connecting block 42, so that the second movable valve cover 22 on the top opening of the movable valve body 21 is automatically opened, the human tissue or organ in the movable valve body 21 can be conveniently taken out, and the human tissue or organ can be placed in a clean environment.

When the second movable valve cover 22 needs to be automatically closed, the motor 311 rotates in the reverse direction to drive the sector gear to drive the first movable valve cover 12 and the second movable valve cover 22 to turn downward, i.e., rotate toward the annular inner cavity 113. In the downward rotation process, the limit pin on the fixing seat is abutted on the second spring, the second spring is compressed to play a buffering role, when the first movable valve cover 12 and the second movable valve cover 22 are both embedded into the annular inner cavity 113, the cylinder drives the third plate to do retraction movement, the acting force on the second plate is cancelled, under the reset acting force of the first spring, the second plate is driven to slide on the second guide part 7 and return to the initial state, the second horizontal part of the Z-shaped first plate is just inserted into the second groove 5111 of the second plate, the first movable valve cover 12 and the second movable valve cover 22 are limited, and therefore the automatic closing process of the second movable valve cover 22 is achieved.

At this time, the fourth outer edge of the second movable valve cover 22 is overlapped on the second outer edge of the movable valve body 21, along with the rotation of the movable valve body 21 (opposite to the direction of rotation in the uncovering process), the sixth outer edge of the first movable valve cover 12 is separated from the third depressed area, the second movable valve cover 22 is in a separated state from the first movable valve cover 12, the fourth outer edge of the second movable valve cover 22 is just positioned in the second depressed area of the movable valve body 21, and the flange is overlapped on the third outer edge, so that the second movable valve cover 22 is matched with the movable valve body 21 to form the first valve 1; and then, the movable valve body 21 is continuously rotated, when the movable valve body 21 is rotated to a required angle, the second outer edge of the movable valve body 21 is separated from the first depressed area of the fixed valve body 11, so that the movable valve body 21 is separated from the fixed valve body 11, at the moment, the fourth outer edge of the second movable valve cover 22 is just embedded into the second depressed area to form a whole, the first valve 1 is rotated and descended, the first valve 1 is separated from the annular inner cavity 113 of the fixed valve body 11, when the lifting mechanism 9 is reset to an initial state, the first valve 1 slides out from the first plug connector 141 of the support body 13, so that the first valve 1 is separated from the second valve 2, and the initial independent state is returned again. That is, the second valve 2 is inserted into or removed from the first valve 1 by the lifting mechanism 9; and then under the action of the rotating mechanism 10, the second valve 2 is rotated by a required angle, so that the second valve 2 and the first valve 3 are automatically butted or separated, the transmission efficiency of the transmission device is improved, and the biological tissues or organs in the second valve 2 are ensured to be always in a clean environment in the whole transmission process.

Meanwhile, in the process of opening or closing the cover, the rotating point of the sector gear is used as a fulcrum, the second driving component 31 and the first movable valve cover 12 are respectively positioned at two sides of the rotating point of the sector gear, so that a lever principle is formed, and the acting force required by the rotating motor 311 for directly driving the first movable valve cover 12 to rotate is reduced; in addition, the sector gear can also be used as a balancing weight to balance the balance weights on two sides of the fulcrum, so that the first movable valve cover 12 and the second movable valve cover 22 can be opened or closed conveniently.

As an alternative embodiment, the adjusting mechanism 5 and the second driving assembly 31 may also be distributed at other positions on the circumference of the fixed valve body 11, and only need to be arranged in a staggered manner.

As a variation, the buffering assembly may be of other structures, and only needs to be used for buffering the acting force applied when the first movable valve cover 12 is turned over, for example, a single suspension ring structure is provided. As a further variation, the cushioning component may not be provided.

As a modification, the longitudinal cross-sectional shape of the second guide 7 may also be rectangular, triangular or other shapes, and correspondingly, a rectangular, triangular or other shaped second notch is formed in the bottom of the sliding body, so that the sliding body can slide linearly on the second guide 7. As a modification of the second notch, a through hole corresponding to the shape of the second guide 7 may be formed, and the second guide 7 may be mounted on the mounting plate by using another structure. As a further variant, the second guide 7 may also be a sliding rail arranged on the mounting plate, on which the second guide 7 is slidingly arranged. As a modification, the slide body and the second guide 7 may be directly provided on the fixed valve body 11 without providing the mounting plate, and further, the second guide 7 may not be provided.

As a deformation, a boss may not be disposed below the second horizontal portion, and a second corner cut is not disposed on the second plate, and a space for inserting the third plate is defined between the second horizontal portion, the vertical portion in the zigzag shape, and the opening of the second groove 5111 of the second plate.

As a modification, the fixed block may not be provided, and the first spring may be provided at an end of the slider opposite to the second connector 52.

As a modification of the driving member, the driving member may have a straight-line shape or an E-shape, and only one end of the driving member is fixed to the cylinder, and the other end is inserted into or withdrawn from the space between the sliding body and the second connector 52 by sliding. As a variant, the cylinder may be replaced by a motor 311, which only needs to drive the driving member to perform the telescopic movement.

As a deformation of the sliding body, the sliding body may also be a block structure or other structures, and only needs to be slidably disposed on the fixed valve body 11 along the radial direction of the annular inner cavity 113, and a second concave groove 5111 that is recessed inward is formed on the surface of one side facing the annular inner cavity 113.

As a modification of the second connector 52, the second connector 52 may have a T-shaped longitudinal cross-section, an inverted L-shaped longitudinal cross-section, or the like, and it is only necessary that one end of the second connector 52 is fixed to the first movable valve cover 12 and the other end is inserted into the second groove 5111 of the slider.

As a further modification, the limiting component 51 may also have other structures, for example, a slide rail, a slider disposed on the slide rail, and a cylinder disposed below the slide rail, wherein one end surface of the slider facing the second connector 52 is provided with a second groove 5111 or a through hole or a blind hole, and the cylinder drives the slider to perform a lifting motion, so that the other end of the second connector can be inserted into the limiting component to be limited, or separated from the limiting component, and overlapped on the limiting component.

As a further variation, the adjusting mechanism 5 may also have other structures, such as a suction cup made of a magnetic material is disposed on the first movable valve cover 12, a magnet capable of attracting the first suction cup is disposed on the fixed valve body 11, the end of the first movable valve cover 12 away from the second driving component 31 is lifted from the annular inner cavity 113 by magnetic action, and a limiting member is separately disposed on the first movable valve cover 12 to limit the first movable valve cover 12 in the annular inner cavity 113. As a further modification, the above-described adjustment mechanism 5 may not be provided.

As a modification of the fixing member, the fixing member may be a rotary shaft mounted on the fixed valve body 11, and a sector gear is hinged to the rotary shaft, and the sector gear is fixedly connected to the first movable valve cover 12 through an existing connecting member.

As a variant, the second gear may also be a gear of another shape, for example a conical gear, the first movable valve cover 12 being connected to the side wall of the conical gear by means of a connecting element. As a variant, the rotating member may be a gear of another shape, for example a bevel gear, in addition to the first gear 312.

As a modification of the second driving assembly 31, the second driving assembly 31 may further include an air cylinder, a rack 103 driven by the air cylinder, and a gear engaged with the rack 103, and the gear is further engaged with the transition piece 32 to drive the transition piece 32 to rotate so as to drive the first movable valve cover 12 to perform the flipping motion.

In addition, in the matching relationship between the first valve 1 and the second valve 2, the above-mentioned aseptic butt valve may also be another butt valve structure in which the movable valve body 21 is separated from or engaged with the second movable valve cover 22 by a rotation method in the prior art, and is engaged with or disengaged from the fixed valve body 11 and the first movable valve cover 12, respectively. The lifting mechanism, the rotating mechanism, the cover opening mechanism, the adjusting mechanism and other structures are all suitable. As a further modification, the above-described lid opening mechanism and the adjusting mechanism 5 may not be provided.

As a modification of the adjusting member, the adjusting member may have other structures, such as a screw directly fixed on the fixing plate 162, a shaft, a spring, etc., and only the adjusting member can abut against the bottom of the limiting plate 161 when the adjusting member moves upward along with the lifting mechanism 9.

As a variation of the limiting mechanism, the limiting mechanism may further include a limiting plate 161 and a spring disposed on the bottom of the limiting plate 161, when the spring is compressed to the limit, the supporting body 13 cannot move upwards any more, so as to limit the lifting height of the lifting mechanism 9. As a further modification, the above-described stopper mechanism may not be provided.

As a modification of the second guiding structure 15, the second guiding structure 15 may be replaced by a linear slide rail, and an L-shaped slider is disposed on the bottom of the supporting body 13, and the slider is slidably disposed on the slide rail to guide the lifting mechanism 9 to drive the movable valve body 21 to move linearly. As a further modification, the second guide structure 15 described above may not be provided.

As a modification, the supporting platform 181 may not be provided with the slide rail or the arc-shaped limiting block, and as a further modification, the baffle 185 may also be three, four, five, or the like, or the mounting seat 182, the baffle 185, the supporting platform 181, and the supporting column 183 may also not be provided.

As a modification of the first plug 141, the first plug 141 may be a trapezoidal plate, the longer side of which is fixed to the support 13, and the corresponding stopper groove 215 is also a trapezoidal groove. Alternatively, the first plug 141 may be an L-shaped block or other shaped structure. When the movable valve body 21 moves towards or away from the first plug connector 141, the limiting groove 215 is sleeved on the first plug connector 141, or the first plug connector 141 is separated, so that the movable valve body 21 is installed on the supporting body 13, or the movable valve body is taken away from the supporting body 13.

As a variation of the first guiding structure, the first guiding structure may be another structure, such as a slide rail disposed on the supporting body 13, a slider disposed on the bottom of the movable valve body 21, and an existing locking mechanism disposed on the surface facing each other to achieve the mounting or dismounting of the two. As a further variant, it is also possible to dispense with the first guide structure and the support body 13, and to place the second valve 2 directly on top of the lifting mechanism 9 during use.

As a variation, the number of the central angles corresponding to the tooth surfaces of the rotating disk can be 60 degrees, 45 degrees, 70 degrees or the like, and the specific designed angle is determined according to the actual use condition.

As a variant, the dial may be replaced by a gear, for example a sector gear, the rack 103 directly driving the rotation of the gear, the angle of rotation being controlled according to the stroke of the cylinder movement. As a variant, the first drive assembly may also be another mechanism, for example directly driven by the rotary motor 311. As a modification of the elevating mechanism 9, the elevating mechanism 9 may be a linear vibration motor 311 or another conventional elevating mechanism.

The transmission device only comprises the first frame, the first valve 1, the second valve 2, the lifting mechanism 9 and the rotating mechanism 10, the first valve 1 is embedded in the through hole in the worktable 17 in a sealing mode, and the second valve 2 and the first valve 1 can be automatically in sealing butt joint or separation under the cooperation of the lifting mechanism and the rotating mechanism.

Example 2

This embodiment provides a packaging system under clean environment, which comprises a second frame, the sterile transferring device of embodiment 1, at least one heat-sealing mechanism, and a finished product output device. The second rack is provided with a horizontal table top and partition plates arranged on the periphery of the horizontal table top, a mounting cavity with an opening at the top is formed by the partition plates and the top surface of the horizontal table top in a surrounding mode, and a clean environment is formed in the mounting cavity; the sterile transmission device is hermetically arranged at one end of the second frame, and the working table surface 17 is superposed with the horizontal table surface and is used for conveying biological tissues or organs placed in the movable valve body into the installation cavity; the heat sealing mechanism is arranged on the horizontal table top and is used for heat sealing a first cover body made of a required material on the top opening of the box body for containing the biological tissues or organs; and the finished product output device is arranged on the horizontal table top at the other end of the second rack and is used for outputting the packaged finished product from the inside of the clean installation cavity to the outside.

The above-mentioned packaging system, adopt the aseptic transmission device provided in embodiment 1, under the cooperation of lifting mechanism 9 and rotary mechanism 10, realize the automatic butt joint or separation process with the first valve with the second valve, ensure that biological tissue or organ is in clean environmental condition all the time in the transmission process, can not be polluted by the external environment, get into the biological tissue or organ in the installation cavity, under the effect of heat-seal mechanism, on the top opening of the box body of placing biological tissue or organ the first lid of the required material of heat-seal, for example the lid of the super-strength material, accomplish the packing to biological tissue or organ, the finished product after the packing is in exporting the installation cavity through finished product output device, thus improve the work efficiency of the packaging system and lengthen the storage cycle of biological tissue or organ after packing.

Preferably, the heat sealing mechanism is two, one heat sealing mechanism heat-seals the first cover body on the top opening of the case body for placing the biological tissue or organ, then the outer case body is sleeved outside the case body, and the other heat sealing mechanism heat-seals the second cover body made of the required material, for example, the cover body made of aluminum foil, on the top opening of the outer case body, so as to form a double-layer packaging structure for the biological tissue or organ, further isolate the biological tissue or organ from the outside and prolong the storage period of the biological tissue or organ.

Preferably, the packaging system further includes a packaging mechanism disposed on the horizontal table and located between the heat sealing mechanism and the finished product output device, for packaging an outer bag made of a desired material on the exterior of the box body. The packaging mechanism is used for packaging the outer surface of the outer box with a layer of outer bag, such as a PE bag, so that the two layers of box bodies and the outer bag are packaged on the outer surface of the biological tissue or organ, the isolation of the biological tissue or organ from the outside is further ensured, and the storage period of the biological tissue or organ is further prolonged.

In a preferred embodiment, the mounting cavity is U-shaped, and the sterile transfer device and the finished product output device are respectively located at two ends of the U-shape. The installation cavity design of U-shaped for the shared space of whole frame is little, can also set up the dodge gate at the opening part of U-shaped, and for the clean environment in ensureing the installation cavity, set up required discernment lock at the dodge gate, personnel that have the authority could get into the space between two side wall cavities of U-shaped through the dodge gate in, maintain or operate the part in the U-shaped installation cavity, increase security level and clean environment's level.

In addition, before the packaging system in the clean environment is used, the second valve and the installation cavity in the sterile transmission device are pre-sterilized to serve as a basis for realizing a controllable clean environment subsequently.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims

1. An aseptic transfer device comprising

A first frame having a work table (17);

a sterile docking valve having a first valve (1) and a second valve (2), the first valve (1) being sealingly mounted in-line within a through-bore of the countertop (17); the method is characterized in that: the sterile transfer device further comprises:

the lifting mechanism (9) is used for driving the second valve (2) to move towards or away from the first valve (1);

the rotating mechanism (10) is used for driving the second valve (2) to rotate relative to the first valve (1) by a preset angle required for enabling the second valve (2) to be in sealing butt joint with or separated from the first valve (1);

the lifting mechanism (9) and the rotating mechanism (10) are both arranged below the working table surface (17);

the supporting body (13) is fixed at the top of the lifting mechanism (9);

the first guide structure is used for guiding and detachably mounting the second valve (2) on the supporting body (13) and comprises a first plug connector (141) formed on the top surface of the supporting body (13) and a first groove (214) formed on the bottom surface of the second valve (2) and recessed inwards, and a limiting groove (215) protruding outwards and suitable for being sleeved on the first plug connector (141) is formed in the first groove (214); the second valve (2) can slide towards or away from the first plug connector (141) so that the limiting groove (215) is sleeved on the first plug connector (141) or separated from the first plug connector (141).

2. The sterile transfer device according to claim 1, wherein the rotating mechanism (10) comprises a rotating body (101) located below the work table (17), and a first driving assembly for driving the rotating body (101) to rotate; the lifting mechanism (9) is fixed on one side surface of the rotating body (101) facing the working table top (17).

3. The sterile transfer device of claim 2, wherein: the first driving assembly comprises a first air cylinder (102) and a rack (103) connected with a telescopic shaft of the first air cylinder (102); the surface of the rotating body (101) facing the rack (103) has a tooth surface engaged with the rack (103).

4. The sterile transfer device of claim 2 or 3, wherein: the rotating body (101) is a rotating disc, and the degree of the central angle of the tooth surface of the rotating disc is the preset angle.

5. The sterile transfer device of claim 1, wherein: the first plug connector (141) is a T-shaped plate, and correspondingly, the limiting groove (215) is a T-shaped groove;

the T-shaped groove is sleeved on the horizontal part of the T-shaped plate through the opening of the T-shaped groove.

6. The sterile transfer device of any one of claims 1-3, wherein: the first frame also comprises a supporting table top (181) positioned below the working table top (17), and at least two baffles (185) which connect and oppositely arrange the supporting table top (181) and the working table top (17);

a channel for the supporting body (13) to pass through is formed in the supporting table top (181), and a taking and placing space for the second valve (2) to slide into the supporting body (13) or slide out of the supporting body (13) is defined by the at least two baffles (185), the supporting table top (181) and the working table top (17).

7. The sterile transfer device of claim 6, wherein:

the first guide structure further comprises at least one sliding rail arranged on the supporting table top (181) and used for sliding the second valve (2), and the sliding rail extends from one end of the supporting table top (181) to the edge of the channel along the length direction of the baffle (185); and/or

An arc limiting block is further arranged on the supporting table board (181), and the arc surface of the arc limiting block is suitable for the outer wall surface of the second valve (2) to abut against and is used for limiting the position of the second valve (2) sliding into the supporting body (13).

8. The sterile transfer device of claim 2 or 3, wherein: the lifting mechanism is characterized by further comprising two sets of second guide structures (15) which are oppositely arranged on the rotating body (101) and used for guiding the lifting mechanism (9) to drive the second valve (2) to do linear motion.

9. The sterile transfer device of claim 8, wherein: each set of said second guide structure (15) comprising:

the vertical plate (151) is vertically arranged on the rotating body (101), is positioned on the same side as the lifting mechanism (9), and is provided with a first through hole (1511) extending vertically;

a column (152) fixed to the bottom of the support body (13) and extending toward the rotating body (101) along the longitudinal direction of the first through hole (1511);

and one end of the first guide piece (153) is horizontally fixed on the upright post (152), and the other end of the first guide piece extends into the first through hole (1511).

10. The sterile transfer device of claim 9, wherein: the lifting mechanism further comprises a limiting mechanism arranged on the upright post (152) and used for limiting the lifting height of the lifting mechanism (9).

11. The sterile transfer device of claim 10, wherein: the stop gear includes:

the limiting plate (161) is fixed on the top of the vertical plate (151), and a first notch or a through hole for the upright post (152) to pass through is formed in the limiting plate;

the fixing plate (162) is fixed on the upright post (152) and is positioned below the limiting plate (161);

the adjusting piece avoids the upright post (152) along the length direction of the first through hole (1511) and is installed on the fixing plate (162), and the top of the adjusting piece is opposite to the bottom surface of the limiting plate (161).

12. The sterile transfer device of any one of claims 1-3, wherein: the first valve (1) is provided with a fixed valve body (11) and a first movable valve cover (12), the fixed valve body (11) is provided with an annular inner cavity (113) communicated with the outside, and the first movable valve cover (12) is installed in the annular inner cavity (113) in a sealing embedding mode; the fixed valve body (11) is embedded in the through hole of the working table top (17);

the second valve (2) is provided with a movable valve body (21) and a second movable valve cover (22), the movable valve body (21) is provided with a top opening and a second inner cavity, and the second movable valve cover (22) is installed in the top opening of the movable valve body (21) in a sealing embedding mode;

the rotating mechanism (10) drives the movable valve body (21) to rotate for a preset angle, so that the movable valve body (21) is separated from or matched with the second movable valve cover (22) and is respectively matched with or separated from the fixed valve body (11) and the first movable valve cover (12).

13. The sterile transfer device of claim 12, wherein: the sterile butt joint valve further comprises an automatic cover opening mechanism (3) arranged on the fixed valve body (11) and used for driving the first movable valve cover (12) to turn over when the first movable valve cover (12) is matched with the second movable valve cover (22) so as to open or close the second movable valve cover (22);

automatic mechanism (3) of uncapping includes second drive assembly (31), receives second drive assembly (31) driven transition piece (32), transition piece (32) are back to one end of second drive assembly (31) connect in first movable valve lid (12), second drive assembly (31) drive transition piece (32) rotate in order to drive first movable valve lid (12) are the upset motion.

14. The sterile transfer device of claim 13, wherein: the sterile docking valve further comprises an adjusting mechanism (5) for lifting or restraining the end of the first movable valve cover (12) remote from the second drive assembly (31) from the annular inner cavity (113) into the annular inner cavity (113).

15. The sterile transfer device of claim 14, wherein: the adjusting mechanism (5) comprises:

the limiting assembly (51) is movably arranged on the fixed valve body (11);

a second plug connector (52), one end of which is fixed on the first movable valve cover (12);

under the action of the limiting component, the other end of the second plug connector (52) can be inserted into the limiting component (51) to be limited or separated from the limiting component and is lapped on the limiting component.

16. The sterile transfer device of claim 15, wherein: the stop assembly (51) comprises:

the sliding body (511) is arranged on the fixed valve body (11) in a sliding manner along the radial direction of the annular inner cavity (113), and a second concave groove (5111) which is inwards concave is formed in the surface of one side, facing the annular inner cavity (113);

an elastic member (512) which is arranged on one end of the sliding body (511) opposite to the second plug connector (52) and applies acting force to the sliding body (511) towards the second plug connector (52);

the driving piece (513) is slidably arranged on the fixed valve body (11), the sliding direction of the driving piece is perpendicular to that of the sliding body (511), one end of the driving piece can be inserted into or withdrawn from the space between the sliding body (511) and the second plug connector (52) in a sliding mode, and the sliding body (511) is forced to move towards the direction far away from the second plug connector (52) and the other end of the second plug connector (52) is overlapped on the driving piece.

17. The sterile transfer device of any one of claims 16, wherein: the valve body is characterized by further comprising a second guide piece (7) which is fixed on the fixed valve body (11) and extends outwards along the radial direction of the annular inner cavity (113), the second guide piece (7) is embedded into the sliding body (511), and the sliding body (511) can slide linearly on the second guide piece (7).

18. A packaging system in a clean environment comprises

the sterile transfer device of any of claims 1-17 is sealingly mounted at one end of the mounting cavity, the work surface is flush with the horizontal table surface, and the first housing is located in a space enclosed between the second housing and a bottom surface of the horizontal table surface for transporting biological tissue or organs placed in the second valve (2) into the mounting cavity;

and the finished product output device is arranged on the horizontal table top at the other end of the second rack and is used for outputting the packaged finished product from the installation cavity.

19. The clean environment packaging system of claim 18, wherein: the packaging mechanism is arranged on the horizontal table board and positioned between the heat sealing mechanism and the finished product output device, and is used for packaging an outer bag made of required materials outside the box body.

20. A clean environment packaging system as claimed in claim 18 or 19, wherein: the mounting cavity is U-shaped;