CN108285441A - A kind of nicotine-mandelate compound crystal, preparation method and the tobacco product comprising it - Google Patents

Abstract

The invention discloses a nicotine-mandelate complex crystal, the crystal molecular formula is: C ₂₆ H ₃₀ N ₂ O ₆ ; the crystal belongs to the orthorhombic crystal system, the space group is P212121, and the unit cell parameters are: α=β=γ=90.00°. The invention also discloses a preparation method thereof, comprising: a. measuring nicotine and mandelic acid, dissolving mandelic acid in a solvent to obtain a saturated solution, placing the saturated solution of mandelic acid in a water bath environment, stirring and adding nicotine dropwise; b. The reaction liquid in step a is transferred to a light-proof container, subjected to ultrasonic treatment, and then the reaction product is kept away from light at room temperature, and the solvent is volatilized to obtain nicotine mandelate crystals. The complex crystal exhibits obvious slow-release effect in artificial simulated saliva. The invention also discloses a tobacco product containing nicotine-mandelate complex crystal, and the tobacco product is gum-based chewing tobacco, bagged snus, electronic cigarette liquid or heat-not-burn cigarette.

Description

A kind of nicotine-mandelate compound crystal, its preparation method and the cigarette containing it grass products

technical field

The invention belongs to the field of organic crystals, in particular to a nicotine-mandelate complex crystal and a preparation method thereof.

Background technique

Nicotine is the main chemical component of natural alkaloids in tobacco leaves. The molecular structure is composed of two nitrogen heterocycles, the pyrrole ring pKa=7.87, and the pyridine ring pKa=3.15. Due to the influence of aromatization, the nitrogen atom in the pyridine ring has a weak basicity, which is similar to that of aromatic amines. The nitrogen atom in the pyrrolidine ring belongs to a tertiary amine. Since the ring is not aromatic, its basicity is similar to that of an aliphatic tertiary amine, so nicotine is easy to chemically react with an acid. Rose, J.E., et al., Pulmonary delivery of nicotine pyruvate: Sensory and pharmacokinetic characteristics. Experimental and Clinical Psychopharmacology, 2010.18(5): 385-394 reported nicotine pyruvate, and conducted related pharmacokinetic studies. Hwa Jung, B., et al., Different pharmacokinetics of nicotine following intravenous administration of nicotine base and nicotinehydrogen tartarate in rats. Journal of Controlled Release, 2001.77 (3): 183-190 reported the pharmacokinetics of nicotine tartrate in rats Kinetics, but in this study, the nicotine-tartrate solid product and crystal structure were not obtained. Using the unique chemical properties of nicotine, rationally select small organic or inorganic acid molecules, and synthesize nicotine salt complexes through acid-base reactions. Although nicotine exists in another chemical form, it does not affect the smoking effect of nicotine. On the contrary, it can improve the taste to a certain extent. By forming salt, nicotine can be solidified, which can also improve the slow-release effect of nicotine and reduce the Irritating to the digestive tract. Therefore, the nicotine compound shows potential application value in the tobacco industry.

At present, in addition to traditional end-lit cigarettes, there are also gum-based chewing tobacco, pouched snus, electronic cigarettes, heat-not-burn cigarettes, etc. on the market, which are usually new tobacco products. These new tobacco products either use tobacco as the direct raw material, or add nicotine directly, which will cause the nicotine to be released too fast and too violently when the product is consumed, and some products with high nicotine content may even cause certain oral and gastrointestinal symptoms. Or respiratory irritation, causing physical discomfort.

Therefore, it is necessary to improve the intake mode of nicotine.

Contents of the invention

The first aspect of the present invention provides a nicotine-mandelate complex crystal, which is used in various forms of tobacco products, such as traditional cigarettes, cigars, electronic cigarettes, heat-not-burn cigarettes and smokeless tobacco products Nicotine infusion forms offer more.

The purpose of the present invention is achieved through the following technical solutions:

A nicotine-mandelate complex crystal, the crystal molecular formula is: C ₂₆ H ₃₀ N ₂ O ₆ .

The above complex crystal molecule is composed of a hydrogenated nicotine cation (monovalent), a mandelic acid ion (monovalent) and a mandelic acid molecule.

The above-mentioned crystals are confirmed by single crystal X-ray diffraction experiments and crystal structure calculations. The crystals belong to the orthorhombic crystal system, space group P212121, unit cell parameters: unit cell parameters: α=β=γ=90.00°.

The unit cell volume of the above-mentioned crystal The number of asymmetric units in the unit cell is Z=4, R ₁ =0.0608, wR ₂ =0.0949, and its crystal structure is shown in FIG. 2 .

The above-mentioned crystal density is 1.255g/cm ³ , and the relative molecular mass is 466.52.

A second aspect of the present invention provides a method for preparing nicotine-mandelate complex crystals, comprising the following preparation steps:

a. Measure nicotine and mandelic acid, dissolve mandelic acid with a solvent to obtain a saturated solution, place the saturated solution of mandelic acid in a water bath environment, stir and add nicotine dropwise;

b. The reaction liquid in step a is transferred to a light-proof container, ultrasonicated, and then the reaction product is kept away from light at room temperature, and the solvent is volatilized to obtain nicotine mandelate crystals.

Wherein, the mandelic acid is selected from one or more of D-mandelic acid, L-mandelic acid and DL-mandelic acid.

Preferably, the solvent in step a is selected from one or more of water, acetone, ethyl acetate, ether, methanol, ethanol, isopropanol, butanol, methylene chloride, chloroform, dimethyl sulfoxide .

Preferably, the molar ratio of nicotine to mandelic acid in step a is 1:2, the ambient temperature of the mandelic acid water bath is 15°C-50°C, and the pH of the reaction solution is <7.0.

Preferably, the ultrasonic temperature in step b is 15°C-50°C; the ultrasonic frequency is 20KHz-120KHz; and the ultrasonic time is 1-10h.

The third aspect of the present invention relates to a tobacco product comprising the nicotine-mandelate complex crystal described in the first aspect of the present invention, wherein the tobacco product is gum-based chewing tobacco, snus in pouches, electronic cigarette liquid or Heat-not-burn cigarettes.

Wherein, when the tobacco product is gum-based chewing tobacco, it also includes gum base, sweetener, acid-base regulator, flavoring agent, food coloring, humectant; wherein the gum base includes rubber, esters One or more of paraffin, hardened oil, and its weight percentage is 10-30%; the sweetener includes one or more of monosaccharides, disaccharides, trisaccharides, polysaccharides, polyalcohols, sweeteners Various, its weight percentage is 20～70%; The described acid-base regulator is selected as one or both in sodium bicarbonate, sodium carbonate, and its weight percentage is 1～10%; The described flavoring agent is selected from lemon , mint, coffee, strawberry, blueberry, pineapple, peach, apple, orange, watermelon, red date, ebony, Yunnan olive extract flavoring agent or spices, the percentage by weight is 1-10%; the edible The pigment is selected from one or more of red yeast rice, chlorophyll, curcumin, carotene, amaranth, and sugar color, and its weight percentage is 0.1% to 10%; the humectant is one of propylene glycol and glycerin Or two, the weight percentage is 1-10%, and the weight percentage of the nicotine-mandelate complex crystal is 1-10%.

When the tobacco product is bagged snus, it also includes cellulose, water, sodium chloride, flavoring agent, acid-base regulator, flavoring agent, humectant and antioxidant; wherein, the cellulose One or more selected from natural fibers, microcrystalline cellulose, and cellulose derivatives, the percentage by weight is 45-60%; the percentage by weight of the water is 10-30%; the weight percentage of the sodium chloride Percentage is 3～5%; Described fragrance agent is selected from one or more in lemon, mint, coffee, strawberry, blueberry, pineapple, peach, apple, orange, watermelon, red date, ebony, olive flavor essence and fragrance, its The weight percentage is 5-20%; the acid-base regulator is selected from one or both of sodium bicarbonate and sodium carbonate, and its weight percentage is 1-5%; the corrective agent is selected from monosaccharide, di One or more of sugars, trisaccharides, polysaccharides, polyols, and sweeteners, the percentage by weight is 1 to 15%; the humectant is selected from one or both of propylene glycol and glycerin, Its weight percentage is 1-5%; the antioxidant is selected from one or more of vitamin A, vitamin C, vitamin E, and tea polyphenols, and its weight percentage is 1-5%; the nicotine-mandelic acid The weight percentage of the salt complex crystal is 1-20%.

When the tobacco product is an electronic cigarette liquid, it also includes propylene glycol, glycerin, humectants and flavors and fragrances; wherein, the weight percentage of the propylene glycol and glycerin is 65% to 95%; the moisturizing The agent is selected from one or more of butanediol, polyethylene glycol, triethylene glycol, glyceryl triacetate, and glycerin diacetate, and its weight percentage is 1-20%; the weight percentage of the flavor fragrance is 0.1 ～10%; the weight percentage of the nicotine-mandelate complex crystal is 1～10%.

When the tobacco product is a heat-not-burn cigarette, it also includes fibers, smokers, non-combustible inorganic fillers, binders, combustion enhancers and flavors and fragrances; wherein, the fibers are selected from plant fibers, artificial One or more of fiber, synthetic fiber and mineral fiber, the percentage by weight is 30-70%; the smoke-generating agent is selected from polyol, propylene glycol, glycerol, triethylene glycol, sorbitol, xylitol , ethylene glycol, ester, alkane, and its percentage by weight is 10-30%; the non-combustible inorganic filler is selected from calcium carbonate, magnesium oxide, magnesium sulfate, silicon dioxide, chalk, perlite , diatomite, non-combustible inorganic filler or one or more, its weight percentage is 10-50%; the binder is one or both of organic binder, non-combustible inorganic binder , its weight percentage is 5-20%; the described combustion enhancer is a potassium salt, its weight percentage is 1-3%; One or more of solanone, licorice, coffee, β-damascenone, and tobacco extract, the percentage by weight is 1-20%; the percentage by weight of the nicotine-mandelate complex crystal is 1-20% %.

Beneficial effects of the present invention:

The present invention combines nicotine and mandelic acid by forming a salt and forms a single crystal by finely controlling crystallization conditions for the first time. The crystal shows obvious slow-release effect in artificial simulated saliva, so that the solid product can be applied to various forms of tobacco Products such as traditional cigarettes, cigars, e-cigarettes, heat-not-burn cigarettes, and smokeless tobacco products provide more possibilities for the introduction of nicotine in the formulation design and quality control research. In the experiment, it was found that the use of nicotine mandelate compound crystals significantly reduced the irritation to the mouth, stomach and respiratory tract of smokers.

In addition, by introducing the nicotine-mandelate complex crystal of the present invention into tobacco products, mandelic acid can also be delivered to users. Mandelic acid can help cell renewal, make skin smooth and delicate, and has certain health care functions.

Description of drawings

Fig. 1 is the crystal structure figure of nicotine-mandelate complex;

Fig. 2 is nicotine-mandelate complex crystal hydrogen bond figure;

Fig. 3 is a nicotine-mandelate complex crystal structure stacking diagram;

Fig. 4 is a physical picture of nicotine-mandelate complex crystals.

Figure 5 shows the results of gum-based chewing tobacco containing nicotine-mandelate complex crystals (product 3), gum-based chewing tobacco containing pure nicotine (product 1) and gum-based chewing tobacco containing shredded tobacco (product 2) Comparison chart of nicotine dissolution in vitro.

Fig. 6 shows the pictures of snus in pouches containing nicotine-mandelate complex crystals (product 3A), snus in pouches containing pure nicotine (product 1A) and snus in pouches containing shredded tobacco (product 2A). Comparison chart of nicotine dissolution in vitro.

Detailed ways

The following examples are intended to illustrate the content of the present invention, rather than to further limit the protection scope of the present invention.

Example 1

1. Preparation of nicotine-mandelate complex crystals

Accurately measure nicotine (purity ≥ 99%) and mandelic acid (purity ≥ 98%) with a molar ratio of 1:2. Dissolve mandelic acid with an appropriate amount of ethanol to prepare a saturated solution, place the saturated mandelic acid solution in a water bath environment at 30°C, stir well and slowly add nicotine dropwise to control the pH=5.5. After the dropwise addition, the reaction liquid was transferred to a light-proof container, and ultrasonicated at a frequency of 80KHz for 5h in an environment of 30°C. The reaction product is kept away from light at room temperature, the solvent is slowly evaporated, and nicotine-mandelic acid complex crystals can be obtained after 20 days.

2. Characterization of nicotine-mandelate complex crystal single crystal structure

The flaky crystals of suitable size obtained by culturing at room temperature were selected, and X-ray single crystal diffraction test was carried out by Xcalibur Eos diffractometer.

The test conditions are: MoK _α radiation, λ=0.71073, 293K, θ scan range 3.13-26.37°, Olex2-1.1 (SHELX-97) software package for structure analysis and refinement.

X-ray single crystal diffraction (SXRD) structural analysis shows that the nicotine-mandelic acid complex crystal is composed of a nicotine cation (monovalent) and a mandelic acid ion (monovalent) and a mandelic acid molecule. The crystal structure is shown in Figure 2 . The stoichiometric formula of the complex is C ₂₆ H ₃₀ N ₂ O ₆ , the relative molecular weight of a single molecule is 466.52, and the calculated crystal density is 1.255 g/cm ³ . At the same time, SXRD results show that the complex belongs to the orthorhombic crystal system, space group P212121. The unit cell parameters are: α=β=γ=90.00°, Z=4, the analysis results R1=0.0608, wR2=0.0949.

In addition to the close combination of nicotine-mandelate complex crystals by electrostatic interaction (ionic bonds), hydrogen bonds also play an important role in the formation of its spatial structure. The hydrogen bond interaction in the nicotine-mandelic acid complex crystal is shown in Figure 3, and the hydrogen bond data are listed in Table 1.

Table 1 Hydrogen bond data of nicotine-mandelate complex crystals

The nitrogen (N ₂ ) on the pyrrole ring of the nicotine molecule combined with the mandelic acid carboxyl group (-CO ₄ O ₅ H) provided H ⁺ to become -NH+-, and -O5H lost H+ to become O5-, so O5- has a larger charge Negative, through the N2-H2···O5 and O6-H6A···O5 hydrogen bonds, it is connected to the nicotine ion and another neutral mandelic acid molecule in the lattice. In addition, the mandelic acid ion containing O5- is also connected by another nicotine ion of C6-H6···O3 and C8-H8B···O3, and itself is also connected by intramolecular hydrogen bond O3-H3A···O4 Form the S(5) ring planar structure. The neutral mandelic acid molecules in the complex are mainly bound in the crystal lattice by hydrogen bonding forces, as described above, the molecule is connected to a mandelate ion by O6-H6A...O5 hydrogen bonds, and also by O8-H8... · N1 and C9-H9A · · · O6 link two different nicotine ions. From the stacking diagram of the crystal structure, as shown in Figure 3, it can be clearly seen that nicotine ions and mandelic acid ions are closely combined in pairs and form a diamond-shaped grid structure as a whole, and a neutral mandelic acid molecule is inserted in each diamond-shaped lattice .

Example 2

1. Preparation of nicotine-mandelate complex crystal gum-based chewing tobacco

a, get styrene-butadiene rubber 30%, cyclamate 56%, propylene glycol 1%, glycerin 2%, coffee fragrance 1%, Yunnan olive extract fragrance 4%, sodium carbonate 2%, Carotene 1%, nicotine-mandelate complex 3%;

b. Baking the gum base first, mixing the materials evenly, stirring at 60°C for 60 minutes, forming, extruding, roller rolling, cutting, aging, and subpackaging is the finished product.

2. Nicotine dissolution test in vitro

The product prepared in step 1, the gum-based chewing tobacco containing pure nicotine, and the gum-based chewing tobacco containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

The present invention utilizes an oral cavity simulated chewing instrument to perform in vitro dissolution tests of nicotine on the above three gum-based chewing tobacco products.

Test method: Add the artificial saliva prepared according to Table 2 into the liquid storage bottle, and place it in a constant temperature water bath to keep the temperature at 37°C. Turn on the machine, set the temperature at 37°C, set the parameters of the simulated dissolution device according to Table 3, take the gum-based chewing tobacco sample and put it into the solution dish, and the chewing manipulator and the left and right opening and closing rotating components in the simulated oral cavity will start under the drive of the motor. Work, after reaching the number of chewing times set by the system, the motor stops working, and then the liquid is discharged, the peristaltic pump pumps out the extract in the solution dish, and the nicotine content in the extract is measured. The obtained results are shown in Figure 5.

Table 2 Artificial saliva formula

Table 3 simulated chewing parameters

The results show that using nicotine-mandelate complex crystals as the form of nicotine introduction (product 3) can significantly slow down the release rate of nicotine in the product and achieve the effect of slow release, especially in the first 10 minutes before consumption, the release rate is slow and peaceful, far lower than For direct added nicotine (Product 1) and products with added tobacco material (Product 2). After evaluation by relevant personnel, the product added with nicotine-mandelate complex can provide a continuous taste and satisfaction, and the irritation to the digestive tract is significantly lower than the other two products.

Example 3

1. Preparation of pouched snus containing nicotine-mandelate complex crystals

a. Take 45% of microcrystalline cellulose, 5% of lemon essence, 5% of propylene glycol, and 15% of nicotine-mandelate complex;

b. After mixing and sieving the materials, take the powder with a particle size of 20 mesh and mix evenly. After baking and heat treatment in a pasteurizer, add 15% of water, 3% of sodium chloride, and 2% of sodium carbonate. Evenly, refrigerated for 12 hours, sprayed with 4% honey, 4% glucose, 1% aspartame, and 1% vitamin E, sealed and refrigerated for 24 hours, sterilized by ultraviolet light for 3 hours, and divided into finished products.

2. Nicotine dissolution test in vitro

The product prepared in step 1, the bagged snus containing pure nicotine, and the bagged snus containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

The present invention utilizes an oral cavity simulated chewing instrument to perform in vitro dissolution tests of nicotine on the above three bagged snus products.

Test method: Add the artificial saliva prepared according to Table 4 into the liquid storage bottle, and place it in a constant temperature water bath to keep the temperature at 37°C. Turn on the machine, set the temperature at 37°C, set the parameters of the simulated dissolution device according to Table 5, take the gum-based chewing tobacco sample and put it into the solution dish, and the chewing manipulator and the left and right opening and closing rotating components in the simulated oral cavity will start under the drive of the motor. Work, after reaching the number of chewing times set by the system, the motor stops working, and then the liquid is discharged, the peristaltic pump pumps out the extract in the solution dish, and the nicotine content in the extract is measured. The obtained results are shown in Figure 1.

Table 4 Artificial saliva formula

Table 5 simulated chewing parameters

The results show that using nicotine-mandelate complex crystals as the form of nicotine introduction (product 3) can significantly slow down the release rate of nicotine in the product and achieve the effect of slow release, especially in the first 10 minutes before consumption, the release rate is slow and peaceful, far lower than For direct added nicotine (Product 1) and products with added tobacco material (Product 2). After evaluation by relevant personnel, the product added with nicotine-mandelate complex can provide a continuous taste and satisfaction, and the irritation to the digestive tract is significantly lower than the other two products

Example 4

An electronic cigarette liquid containing nicotine-mandelate complex crystals, which is composed of the following components in weight percentage: 25% propylene glycol, 55% glycerin, 1.5% vanilla flavor, 0.5% coffee flavor, nicotine-mandelic acid Salt Complex 5%, Polyethylene Glycol 6%, Cocoa Flavor 1%, Cookie Flavor 1%, Tobacco Extract Flavor 5%.

Comparative example 4

An ordinary conventional e-cigarette liquid consists of the following components by weight percentage: 25% propylene glycol, 55% glycerin, 1.5% vanilla flavor, 0.5% coffee flavor, 5% nicotine, 1% cocoa flavor, polyethylene Glycol 6%, Cookie Flavor 1%, Tobacco Extract Flavor 5%.

Relevant evaluation experts were organized to compare and evaluate Embodiment 4 and Comparative Example 4, and scored, and the scoring table is shown in the table below (the higher the score, the better the corresponding index). The e-cigarette liquid added with nicotine-mandelate complex crystals is better than the e-liquid directly added with nicotine in terms of coordination, stimulation and aftertaste, especially the aroma is significantly better than that of Comparative Example 4, and the overall continuous satisfaction Feel and taste are better.

Table 6 Original records of electronic cigarette sensory quality inspection

Example 5

A heat-not-burn cigarette stick containing nicotine-mandelate compound is composed of the following components in weight percentage: 60% of plant fiber, 5% of nicotine-mandelate compound, 20% of calcium carbonate, 2.5% of propylene glycol, Glycerin 2.5%, vanillin 1%, macrostigmatrienone 2%, potassium salt 1%, carboxymethyl cellulose 6%.

Comparative example 5

A heat-not-burn cigarette containing tobacco reconstituted tobacco leaves is composed of the following components in weight percent: 65% reconstituted tobacco leaves, 20% calcium carbonate, 2.5% propylene glycol, 2.5% glycerin, 1% potassium salt, and macrostigmatrienone 2%, vanillin 1%, carboxymethyl cellulose 6%.

Organizing relevant appraising and sucking experts, compared and appraised embodiment 5 and comparative example 5, and scored (the higher the score, the better the appraised and sucked effect), the scoring table is as shown in table 7. The heat-not-burn cigarettes with nicotine-mandelate complex are better in coordination, stimulation and taste than the heat-not-burn cigarettes with conventional reconstituted tobacco leaves, and the overall continuous satisfaction and taste are better it is good.

Table 7 Original records of sensory quality inspection of heat-not-burn cigarettes

Claims (10)

1. a kind of nicotine-mandelate compound crystal, which is characterized in that its crystal molecule formula is C₂₆H₃₀N₂O₆；The crystalline substance Body belongs to rhombic system, space group P212121, cell parameter： α=β=γ=90.00 °.

2. crystal according to claim 1, which is characterized in that the crystalline density is 1.255g/cm³, relative molecular mass It is 466.52.

3. crystal according to claim 1, which is characterized in that asymmetry unit number Z=4 in the structure cell of the crystal, it is brilliant Cell space accumulatesR₁=0.0608, wR₂=0.0949.

4. the preparation method of nicotine according to claim 1-mandelate compound crystal, which is characterized in that including Following preparation process：

A, nicotine and mandelic acid are measured, saturated solution is made with solvent dissolving mandelic acid, mandelic acid saturated solution is placed in water It bathes in environment, stirs and nicotine is added dropwise；

B, the reaction liquid in step a is transferred in light resistant container, is ultrasonically treated, then reaction product is protected from light and is placed in room temperature Under environment, solvent flashing, you can obtain nicotine mandelate crystal.

5. nicotine according to claim 4-mandelate compound crystal preparation method, which is characterized in that described flat Peach acid be selected from D- mandelic acids, L- mandelic acids, DL- mandelic acids it is one or more.

6. nicotine according to claim 4-mandelate compound crystal preparation method, which is characterized in that in step a Solvent be selected from water, acetone, ethyl acetate, ether, methanol, ethyl alcohol, isopropanol, butanol, dichloromethane, chloroform, diformazan It is one or more in sulfoxide.

7. nicotine according to claim 4-mandelate compound crystal preparation method, which is characterized in that in step a The molar ratio of the nicotine and mandelic acid is 1:2, the mandelic acid water bath temperature is 15 DEG C -50 DEG C, the reaction solution PH<7.0.

8. nicotine according to claim 1-mandelate compound crystal preparation method, which is characterized in that in step b The ultrasonic temperature is 15 DEG C -50 DEG C；The supersonic frequency is 20KHz-120KHz；The ultrasonic time is 1-10h.

9. including the tobacco product of nicotine described in claim 1-mandelate compound crystal, wherein the tobacco product For gum base type chewing tobacco, packed buccal cigarette, tobacco juice for electronic smoke or heat not burning type Cigarette.

10. tobacco product according to claim 9, it is characterised in that：

Further include matrix, sweetener, acid-base modifier, flavouring agent, edible color when the tobacco product is gum base type chewing tobacco Element, humectant；The wherein described matrix includes one or more in rubber, esters, paraffin, fixed oil, and weight percent is 10~30%；The sweetener includes one or more in monosaccharide, disaccharides, trisaccharide, polysaccharide, polyalcohol, sweetener, weight Percentage is 20~70%；The acid-base modifier is selected as one or both of sodium bicarbonate, sodium carbonate, weight percent It is 1~10%；The flavouring agent is selected from lemon, peppermint, coffee, strawberry, blueberry, pineapple, peach, apple, orange, watermelon, red One or more in jujube, dark plum, Yunnan olive extract flavouring agent fragrance, weight percent is 1~10%；The edible color Element is one or more in red yeast rice, chlorophyll, curcumin, carrotene, three-coloured amaranth, fried sugar, weight percent 0.1% ~10%；The humectant is one or both of propylene glycol, glycerine, and weight percent is 1~10%, and the Buddhist nun is ancient The weight percent of butyl- mandelate compound crystal is 1~10%；

When the tobacco product be packed buccal cigarette when, further include cellulose, water, sodium chloride, flavouring agent, acid-base modifier, Corrigent, humectant and antioxidant；Wherein, the cellulose is in natural fiber, microcrystalline cellulose, cellulose derivative It is one or more, weight percent be 45~60%；The weight percent of the water is 10~30%；The sodium chloride Weight percent is 3~5%；The flavouring agent is selected from lemon, peppermint, coffee, strawberry, blueberry, pineapple, peach, apple, tangerine One or more in son, watermelon, jujube, dark plum, olive taste essence and flavoring agent, weight percent is 5~20%；The soda acid Conditioning agent is selected from one or both of sodium bicarbonate, sodium carbonate, and weight percent is 1~5%；The corrigent is selected from single One or more in sugar, disaccharides, trisaccharide, polysaccharide, polyalcohol, sweetener, weight percent is 1~15%；The humectation Agent is selected from one or both of propylene glycol, glycerine, and weight percent is 1~5%；The antioxidant is selected from vitamin A, one or more in vitamin C, vitamin E, tea polyphenols, weight percent is 1~5%；Nicotine-the mandelic acid The weight percent of salt composite crystal is 1~20%；

Further include propylene glycol, glycerine, humectant and essence and flavoring agent when the tobacco product is tobacco juice for electronic smoke；Wherein, The weight percent of the propylene glycol and glycerine is 65~95%；The humectant is selected from butanediol, polyethylene glycol, three sweet One or more in alcohol, glyceryl triacetate, diacetine, weight percent is 1~20%；The essence and flavoring agent Weight percent 0.1~10%；The weight percent of the nicotine-mandelate compound crystal is 1~10%；

Further include fiber, smoke agent, noninflammability is inorganic fills out when the tobacco product is heating not burning type Cigarette Material, adhesive, combustion adjuvant and essence and flavoring agent；Wherein, it is fine to be selected from plant fiber, staple fibre, synthetic fibers, mineral for the fiber One or more in dimension, weight percent is 30~70%；The smoke agent is selected from polyalcohol, propylene glycol, glycerine, three One or more in glycol, sorbierite, xylitol, ethylene glycol, ester, alkane, weight percent is 10~30%；It is described not The inorganic filler of combustion property is selected from that calcium carbonate, magnesia, magnesium sulfate, silica, chalk, perlite, diatomite, noninflammability is inorganic fills out One or more in material, weight percent is 10~50%；Described adhesive is organic bond, noninflammability inorganic bond One or both of agent, weight percent are 5~20%；The combustion adjuvant is sylvite, and weight percent is 1~3%； The essence and flavoring agent is selected from licorice, coffee-extract, vanillic aldehyde, Megastigmatrienone, solanone, Radix Glycyrrhizae, coffee, the big horses of β- One or more in ketone, tobacco extract, weight percent is 1~20%；The nicotine-mandelate compound is brilliant The weight percent of body is 1~20%.