CN108283533A - A kind of surface of a wound cells in situ transplanting culture apparatus - Google Patents
A kind of surface of a wound cells in situ transplanting culture apparatus Download PDFInfo
- Publication number
- CN108283533A CN108283533A CN201711499800.2A CN201711499800A CN108283533A CN 108283533 A CN108283533 A CN 108283533A CN 201711499800 A CN201711499800 A CN 201711499800A CN 108283533 A CN108283533 A CN 108283533A
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- China
- Prior art keywords
- wound
- material layer
- organization bracket
- cells
- situ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
- A61F13/0209—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings comprising superabsorbent material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00157—Wound bandages for burns or skin transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present invention provides a kind of surface of a wound cells in situ to transplant culture apparatus, including organization bracket, and imbibition material layer is equipped on the organization bracket, medical pad pasting is equipped on the imbibition material layer.The microenvironment that the device provides is conducive to culture and the wound repairing of transplanted cells, and surface of a wound during wound repair can be avoided using the device because endogenous or exogenous infection risk.
Description
Technical field
The present invention relates to a kind of surface of a wound cells in situ to transplant culture apparatus.
Background technology
Skin has the function of to keep moisture, breathe freely and prevent bacteria attack etc. as human organ.When skin is by outer
The damages such as wound, burn, inflammation, especially when the skin of large area is severely damaged, wound should be protected immediately.
If being only that the shallow-layer of skin or small area are damaged, new skin can be regenerated self.If the large area skin of deep layer by
To wound, skin cannot realize selfreparing, must usually carry out auto-skin grafting, such as stamp skin-grafting, mesh graft, transfer skin
The methods of valve, or use artificial skin products.There is skin inducing self-body skin group in the artificial skin product of the prior art
Repair ability deficiency is knitted, and there are the surface of a wound during wound repair because of endogenous or exogenous hydrops or the risk of infection.
The human body surface of a wound is self or homogeneous variant cell, the sprinkling transplanting regeneration of stem cells wound surface surface are that presently relevant technology is ground
One of emphasis and hot spot for studying carefully, but the suitable microenvironment that local regeneration induction how is provided for transplanted cells is extremely important.
Invention content
The object of the present invention is to provide a kind of surface of a wound cells in situ to transplant culture apparatus.
To achieve the above object, the technical solution used in the present invention：A kind of surface of a wound cells in situ transplanting culture apparatus,
It is characterized in that, including organization bracket, imbibition material layer is equipped on the organization bracket, doctor is equipped on the imbibition material layer
Use pad pasting.The medical pad pasting coats the organization bracket and the imbibition material layer.
As the preferred embodiment of the present invention, the organization bracket be acellular matrix, collagen matrices rack or
Collagen gel sponge.
As the preferred embodiment of the present invention, the length of the imbibition material layer is greater than or equal to the organization bracket
Length.
As the preferred embodiment of the present invention, the length of the medical pad pasting is more than the length of the imbibition material layer,
The width of the medical pad pasting is more than the width of the imbibition material layer；The length of the medical pad pasting is more than the organization bracket
Length, the width of the medical pad pasting is more than the width of the organization bracket.
The present invention provides a kind of wound repair devices, including surface of a wound cells in situ described above to transplant culture apparatus,
Further include repair cell layer, the organization bracket is between the repair cell layer and the imbibition material layer.
As the preferred embodiment of the present invention, the repair cell layer includes that the human body surface of a wound is self or homogeneous variant cell
Layer or layer.
The beneficial effects of the present invention are：The present invention provides a kind of surface of a wound cells in situ transplanting culture apparatus, the device group
It is that acellular matrix, collagen matrices rack or collagen gel sponge are constituted to knit shelf layer, provides transplanted cells and gradually climbs
What row was grown into is similar to the same organization bracket of human epidermal cellular matrix, is more conducive to inducing transplantation cell, stem cell life
Long, organization bracket layer is in three-dimensional network spline structure, and mesh size fluid molecule can pass through, but cell size substance can not lead to
It crosses；Organization bracket is placed in the human body surface of a wound, and the effect of wound comprehensive factor is completely dissolved in general 1 to 2 week.Imbibition material layer is persistently inhaled
The extra sepage of the surface of a wound is received, the suitable local growth humidity of transplanted cells is kept, be conducive to the culture of transplanted cells and repairs wound
Face, medical foil layer stick in surface of a wound surrounding normal skin by surface of a wound transplanted cells be equal to ambient enviroment it is completely isolated, can keep away
Exempt from the risk for the cross-infection that the surface of a wound is exogenous during wound repair.Because the cell transplantation wound repair time is longer, this
The medical foil layer of device and imbibition material layer can be replaced at any time, and also avoid that surface of a wound part hydrops forms local infection can
Energy.
Description of the drawings
Fig. 1 is the structural schematic diagram that surface of a wound cells in situ of the present invention transplants culture apparatus；
Fig. 2 is the structural schematic diagram for the imbibition material layer that surface of a wound cells in situ of the present invention transplants culture apparatus；
Fig. 3 is the state diagram using surface of a wound region after surface of a wound cells in situ of the present invention transplanting culture apparatus；
Fig. 4 is that surface of a wound cells in situ of the present invention transplants the state diagram after culture apparatus use；
1, organization bracket wherein in figure, 2, imbibition material layer, 3, medical pad pasting, 4, transplanted cells, 5, the surface of a wound, 6, corium
Layer, 7, hydrone.
Specific implementation mode
Embodiment 1
A kind of embodiment of surface of a wound cells in situ transplanting culture apparatus of the present invention, as shown in Figure 1, include organization bracket 1,
The organization bracket 1 is equipped with imbibition material layer 2, and the structure of imbibition material layer 2 is as shown in Fig. 2, on the imbibition material layer 2
Equipped with medical pad pasting 3.The length of the medical pad pasting 3 is more than the length of the imbibition material layer 2, the width of the medical pad pasting 3
Width of the degree more than the imbibition material layer 2；The length of the medical pad pasting 3 is more than the length of the organization bracket 1, the doctor
It is more than the width of the organization bracket 1 with the width of pad pasting 3.Organization bracket layer is in three-dimensional network spline structure, mesh size liquid
Molecule can pass through, but cell size substance can not pass through；Organization bracket is placed in the human body surface of a wound, and wound comprehensive factor acts on, and one
As be completely dissolved in 1 to 2 week.The extra sepage of the imbibition material layer constant absorption surface of a wound keeps the suitable local growth of transplanted cells dry
Humidity, is conducive to culture and the wound repairing of transplanted cells, and medical foil layer sticks in surface of a wound surrounding normal skin and moves the surface of a wound
It is completely isolated equal to ambient enviroment to plant cell, the wind for the cross-infection that the surface of a wound is exogenous during wound repair can be avoided
Danger.Because the cell transplantation wound repair time is longer, the medical foil layer of the present apparatus and imbibition material layer can be replaced at any time, also keep away
The possibility that surface of a wound part hydrops forms local infection is exempted from.
Further, the length of the imbibition material layer 2 could be provided as the length more than the organization bracket 1.
Further, the organization bracket 2 can be acellular matrix, collagen matrices rack or collagen gel sea
It is continuous.Provide transplanted cells gradually creep grow into be similar to the same organization bracket of human epidermal cellular matrix, advantageously
In inducing transplantation cell, stem cell growth.
Wound repair device of the present invention, as shown in Figure 1, culture apparatus is transplanted including surface of a wound cells in situ described above,
Further include transplanted cells layer, the organization bracket is between the transplanted cells layer and the imbibition material layer.
Further, the repair cell layer includes the self human body surface of a wound or homogeneous variant cell layer or layer.
The application method of surface of a wound cells in situ transplanting culture apparatus of the present invention：
Transplanted cells 4 are inoculated in the surface of a wound 5 first, the surface of a wound after inoculation transplanted cells 4 are then covered with organization bracket, then
Imbibition material layer 2 is covered on organization bracket 1, is finally fixed organization bracket 1 and the closing of imbibition material layer 2 with medical pad pasting 3
Get up, during wound repairing 5, the cell of the surface of a wound 5 cannot penetrate organization bracket, and the hydrone 7 of the surface of a wound 5 penetrates organization bracket
1 is absorbed by imbibition material layer 2, as shown in figure 3, imbibition material layer 2 absorbs volume expansion after hydrone, as shown in figure 4, causing to cure
Increased with the closed spatial volume of pad pasting 3, gas pressure declines, in the enclosure space between 1 material of the surface of a wound 5 and organization bracket
Tiny structure is generated, which is conducive to cell culture and reparation of the transplanted cells 4 in the surface of a wound 5.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than is protected to the present invention
The limitation of range is protected, although being explained in detail to the present invention with reference to preferred embodiment, those skilled in the art should
Understand, technical scheme of the present invention can be modified or replaced equivalently, without departing from the essence of technical solution of the present invention
And range.
Claims (6)
1. a kind of surface of a wound cells in situ transplants culture apparatus, which is characterized in that including organization bracket, set on the organization bracket
There is imbibition material layer, medical pad pasting is equipped on the imbibition material layer.
2. surface of a wound cells in situ according to claim 1 transplants culture apparatus, which is characterized in that the organization bracket is de-
Cellular matrix, collagen matrices rack or collagen gel sponge.
3. surface of a wound cells in situ according to claim 1 transplants culture apparatus, which is characterized in that the imbibition material layer
Length is greater than or equal to the length of the organization bracket.
4. surface of a wound cells in situ according to claim 1 transplants culture apparatus, which is characterized in that the length of the medical pad pasting
Degree is more than the length of the imbibition material layer, and the width of the medical pad pasting is more than the width of the imbibition material layer；The doctor
It is more than the length of the organization bracket with the length of pad pasting, the width of the medical pad pasting is more than the width of the organization bracket.
5. a kind of wound repair device, which is characterized in that include the surface of a wound cells in situ transplanting as described in claim 1-4 is any
Culture apparatus further includes transplanted cells layer, and the organization bracket is between the transplanted cells layer and the imbibition material layer.
6. wound repair device according to claim 5, which is characterized in that the repair cell layer include the human body surface of a wound from
Body or homogeneous variant cell layer or layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711499800.2A CN108283533A (en) | 2017-12-29 | 2017-12-29 | A kind of surface of a wound cells in situ transplanting culture apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711499800.2A CN108283533A (en) | 2017-12-29 | 2017-12-29 | A kind of surface of a wound cells in situ transplanting culture apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108283533A true CN108283533A (en) | 2018-07-17 |
Family
ID=62832608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711499800.2A Pending CN108283533A (en) | 2017-12-29 | 2017-12-29 | A kind of surface of a wound cells in situ transplanting culture apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108283533A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025660A1 (en) * | 1992-06-11 | 1993-12-23 | Brigham And Women's Hospital | System and method for transplantation of cells |
| CN104622645A (en) * | 2015-01-29 | 2015-05-20 | 上海市同仁医院 | Medical negative-pressure adsorption dressing and method for using medical negative-pressure adsorption dressing to heal wound surface |
| CN105617461A (en) * | 2016-01-27 | 2016-06-01 | 深圳爱生再生医学科技有限公司 | Skin patch for treating skin burn and preparation method of skin patch |
| CN206792707U (en) * | 2016-10-31 | 2017-12-26 | 广东泰宝医疗科技股份有限公司 | A kind of composite foam electret dermal matrix dressing |
| CN207944107U (en) * | 2017-12-29 | 2018-10-09 | 广东美捷威通生物科技有限公司 | A kind of surface of a wound cells in situ transplanting culture apparatus |
-
2017
- 2017-12-29 CN CN201711499800.2A patent/CN108283533A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025660A1 (en) * | 1992-06-11 | 1993-12-23 | Brigham And Women's Hospital | System and method for transplantation of cells |
| CN104622645A (en) * | 2015-01-29 | 2015-05-20 | 上海市同仁医院 | Medical negative-pressure adsorption dressing and method for using medical negative-pressure adsorption dressing to heal wound surface |
| CN105617461A (en) * | 2016-01-27 | 2016-06-01 | 深圳爱生再生医学科技有限公司 | Skin patch for treating skin burn and preparation method of skin patch |
| CN206792707U (en) * | 2016-10-31 | 2017-12-26 | 广东泰宝医疗科技股份有限公司 | A kind of composite foam electret dermal matrix dressing |
| CN207944107U (en) * | 2017-12-29 | 2018-10-09 | 广东美捷威通生物科技有限公司 | A kind of surface of a wound cells in situ transplanting culture apparatus |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20180717 |