CN108272903A - A kind of prescription for losing weight and its application process - Google Patents

Abstract

The invention belongs to the technical field of health products, and relates to a slimming formula and an application method thereof. The weight loss formula comprises the following components in mass percentage: 0.1-80% of capsaicinate; 1-80% of menthol; 1-60% of L-carnitine; 1-80% of conjugated linoleic acid. The application method is as follows: each component is weighed according to the mass percentage of the formula, capsaicin ester and menthol are dissolved in an oily solvent, and applied to a living body, then L-carnitine and conjugated linoleic acid are dissolved in water, and continue applied to living organisms.

Description

A kind of weight loss formula and its application method

technical field

The invention belongs to the technical field of health products, and relates to a slimming formula and an application method thereof.

Background technique

Obesity is a chronic metabolic disease in which energy intake exceeds energy expenditure, resulting in excessive accumulation of body fat, which has reached a harmful level. With the abundance of materials and the improvement of living standards, obesity has increasingly become a problem that people are paying more and more attention to and headaches, and has increasingly become a chronic disease that threatens human health in modern society. The so-called obesity is the source of all diseases. In addition to affecting physical and mental health, obesity can also affect the function of the digestive system, endocrine system, increase the risk of cancer and the risk of cardiovascular disease, etc. Many people lose weight by reducing food intake. Although the short-term effect is good, it will have adverse consequences on human health and affect normal life and work. Once the normal diet is restored, it is easy to rebound. Therefore appear a dazzling array of weight-loss products on the market now, comprise weight-loss medicine and weight-loss health food, although the weight-loss effect of weight-loss medicine is more obvious, ubiquitous side effect is big, the shortcoming of strong drug dependence. And although the side effects and dependence of weight-loss health food are small, the effect of weight loss is not obvious. Therefore, it is of great significance to develop new drugs or health foods for the treatment and prevention of obesity.

Contents of the invention

Aiming at the problems in the prior art, the present invention provides a formula using capsaicin, menthol, L-carnitine and conjugated linoleic acid as active ingredients for weight loss. The formula has significant weight loss effect and no side effects.

An object of the present invention can be achieved through the following technical solutions: a weight loss formula, said formula comprising the following components in mass percent: capsaicin ester 0.1-80%; menthol 1-80%; L-carnitine 1-60% %; Conjugated linoleic acid 1-80%.

Capsaicin ester is a natural compound derived from peppers, which can enhance the secretion of adrenal catecholamines by activating the transient receptor potential ion channels TRPV1 and TRPA1 in the body. It has the characteristics of promoting energy metabolism, inhibiting obesity, and non-toxicity. It is clinically used in weight loss has great advantages. Menthol is a commonly used condiment and additive, and it is also a natural agonist of TRPM8 and TRPA1, which can activate TRPM8 and TRPA1, and affect the expression of the thermogenic protein UCP1 and its related molecules through changes in intracellular [Ca ²⁺ ]. Both capsaicinate and menthol can activate the thermogenic function of brown fat in the body and promote the browning of white fat, increase the heat production of mitochondrial aerobic respiration, lead to an increase in the body's metabolic heat production, and consume fat to resist obesity.

L-carnitine, also known as L-carnitine or vitamin BT, is an amino acid that promotes the conversion of fat into energy. The main physiological function of L-carnitine is to assist fatty acids to enter the mitochondria and participate in aerobic respiration, thereby increasing the proportion of fat in the raw materials consumed by aerobic respiration, and promoting the conversion of fat into energy. Taking L-carnitine can reduce body fat and weight without reducing water and muscle. In 2003, L-carnitine was recognized by the International Obesity Health Organization as the safest weight loss nutritional supplement without side effects. Conjugated linoleic acid is a type of linoleic acid isomers containing conjugated double bonds, which are commonly found in ruminant foods, such as milk, cheese, beef, mutton and fat. Conjugated linoleic acid can improve fat metabolism, change body composition and improve health by reducing body fat accumulation and promoting lean muscle growth. It also has a very significant positive effect on obesity prevention.

However, the application of capsaicinoid or menthol alone has a limited effect on fat consumption because it does not affect the proportion of glucose and fat consumed by mitochondria; while the application of L-carnitine alone can increase the proportion of mitochondrial fat consumption, but it does not increase The total amount of energy consumption, so its weight loss effect is usually not good, often need compound aerobic exercise and other factors that increase energy consumption to achieve. Therefore, the present invention uses capsaicin ester and menthol to increase the energy consumption of the body, supplemented with L-carnitine and conjugated linoleic acid to increase the proportion of fat consumption, and promote muscle growth, so as to achieve the effect of reducing fat and increasing muscle .

Preferably, the formula includes the following components in mass percentage: 0.1-40% capsaicinate; 10-50% menthol; 10-50% L-carnitine; 15-55% conjugated linoleic acid.

Preferably, the formula includes the following components in mass percentage: 0.1-10% capsaicinate; 15-20% menthol; 30-40% L-carnitine; 30-40% conjugated linoleic acid.

Preferably, the formula includes the following components in mass percentage: 0.3-0.5% capsaicinate; 19-20% menthol; 39-40% L-carnitine; 39-40% conjugated linoleic acid. The weight loss formula formed with the above mass percentage components is the optimal solution of the present invention, and has the best weight loss effect.

Another object of the present invention can be achieved through the following technical solutions: a method of application of weight loss formula, said application method is: take each component according to formula mass percentage, capsaicinoid and menthol are dissolved in oily solvent , applied to the living body, and then L-carnitine and conjugated linoleic acid were dissolved in water and continued to be applied to the living body.

Due to the different solubility of capsaicin, menthol, L-carnitine, and conjugated linoleic acid, dissolving in the same solvent will inevitably cause uneven dissolution of individual components, thereby affecting the formula effect. In the invention, firstly, capsaicin ester and menthol are dissolved in an oily solvent, and prepared into a certain proportion solution, which is taken orally into the living body, and then L-carnitine and conjugated linoleic acid are dissolved in water to enter the living body. Wherein said oily solvent can be soybean oil, peanut oil, corn oil etc. The capsaicinoid is administered to the living body according to 0.1-10mg/kg body weight, and the specific value is selected according to the weight loss effect that the living body needs to achieve, and the dosage of the remaining three components is determined according to the dosage of the capsaicinoid.

The present invention takes into account the different solubility properties of various components, uses different solvents to dissolve, and applies them to the living body respectively. In addition, various components of the weight loss formula can also be dissolved in the oily formula at the same time through special treatment processes, such as emulsification and microencapsulation. Solvent or water, form a uniform solution and apply it to living organisms.

The weight loss formula provided by the invention can accelerate the decomposition of fat in the body and convert it into energy through the synergistic promotion effect of capsaicin ester, menthol, L-carnitine and conjugated linoleic acid, and at the same time inhibit the body's reaction to fat and carbohydrates. Absorption, so as to achieve the purpose of weight control and weight loss. In addition, the slimming formula provided by the invention has a long-lasting effect, has no toxic and side effects on the human body, does not rebound, and can effectively promote the health of dieters.

Detailed ways

The following are specific examples of the present invention to further describe the technical solutions of the present invention, but the present invention is not limited to these examples. Unless otherwise specified, the raw materials used in the examples of the present invention are commonly used raw materials in the art, and the methods used in the examples are conventional methods in the art.

Example 1

The slimming formula of this embodiment is capsaicin ester 600 mg; menthol 150 mg; L-carnitine 150 mg; conjugated linoleic acid 100 mg. Weigh each component according to formula quality, dissolve capsaicinoid ester and menthol in 600ml soybean oil, stand-by, then dissolve L-carnitine and conjugated linoleic acid in 600ml water, stand-by.

Example 2

The weight loss formula of this embodiment is capsaicin ester 500 mg; menthol 1.8 g; L-carnitine 3.2 g; conjugated linoleic acid 4.5 g. Weigh each component according to the formula quality, dissolve capsaicinoid ester and menthol in 500ml soybean oil, stand-by, then dissolve L-carnitine and conjugated linoleic acid in 500ml water, stand-by.

Example 3

The weight loss formula of this embodiment is 100 mg of capsaicin ester; 5 g of menthol; 10 g of L-carnitine; and 10 g of conjugated linoleic acid. Weigh each component according to the formula quality, dissolve capsaicinoid ester and menthol in 100ml soybean oil, and set aside, then dissolve L-carnitine and conjugated linoleic acid in 100ml water, set aside.

Example 4

The weight loss formula of this embodiment is 100 mg of capsaicin ester; 5 g of menthol; 10 g of L-carnitine; and 10 g of conjugated linoleic acid. Weigh each component according to formula quality, dissolve capsaicinoid ester and menthol in 200ml corn oil, stand-by, then dissolve L-carnitine and conjugated linoleic acid in 200ml water, stand-by.

Example 5

The weight loss formula of this embodiment is 100 mg of capsaicin ester; 5 g of menthol; 10 g of L-carnitine; and 10 g of conjugated linoleic acid. Weigh each component according to formula quality, dissolve capsaicinoid ester and menthol in 40ml corn oil, stand-by, then dissolve L-carnitine and conjugated linoleic acid in 40ml water, stand-by.

Comparative example 1

The difference between Comparative Example 1 and Example 4 is that the weight loss formula of Comparative Example 1 is 5.1 g of menthol; 10 g of L-carnitine; and 10 g of conjugated linoleic acid.

Comparative example 2

The difference between Comparative Example 2 and Example 4 is that the weight loss formula of Comparative Example 2 is 5.1 g of capsaicinoid; 10 g of L-carnitine; and 10 g of conjugated linoleic acid.

Comparative example 3

The difference between Comparative Example 3 and Example 4 is that the weight loss formula of Comparative Example 3 is 100 mg of capsaicinoid; 5 g of menthol; and 20 g of L-carnitine.

Comparative example 4

The difference between Comparative Example 4 and Example 4 is that the weight loss formula of Comparative Example 4 is 100 mg of capsaicin ester; 5 g of menthol; 20 g of conjugated linoleic acid

Comparative example 5

The weight-loss formula of Comparative Example 5 was 850 mg of capsaicin ester; 50 mg of menthol; 50 mg of L-carnitine; and 50 mg of conjugated linoleic acid. Weigh each component according to formula quality, dissolve capsaicinoid ester and menthol in 850ml soybean oil, stand-by, then dissolve L-carnitine and conjugated linoleic acid in 850ml water, stand-by.

The above-mentioned Examples 1-5 and Comparative Examples 1-5 were used to measure the weight loss function. The measurement method is as follows: In this method, high-calorie food is used to induce obesity in animals, and then the test samples are given to observe the changes in animal body weight and body fat content.

1. Experimental animals

Male SD rats with similar body weight were selected, 10 in each group.

2. High-calorie model feed

15% lard, 15% sucrose, 10% egg yolk powder, 1% whole milk powder, 1% mixed salt, 0.1% mixed vitamins, 57.9% basic feed.

3. Experimental steps

3.1 Adaptation period: 170 rats were fed with maintenance feed under the barrier system and observed for 7 days.

3.2 Modeling period:

After the adaptation period, they were randomly divided into two groups according to body weight, 10 rats were given maintenance feed as a blank control group, and 160 rats were given high-calorie model feed. The amount of food given, the amount of sprinkled food, and the amount of leftover food were recorded every week, and the body weight was weighed once.

After feeding for 2 weeks, the 160 rats given high-calorie diet were sorted according to their body weight gain, and 50 obesity-resistant rats with lower body weight gain were eliminated. The 110 obesity-sensitive rats screened out were given high-calorie feed for another 6 weeks, and the blank control group was given maintenance feed at the same time.

3.3 Test sample administration:

After the modeling period ended, 110 obesity-sensitive rats were randomly divided into 11 groups according to body weight, which were respectively model control group, embodiment 1 group, embodiment 2 group, embodiment 3 group, embodiment 4 group, embodiment 5 group, Comparative Example 1 Group, Comparative Example 2 Group, Comparative Example 3 Group, Comparative Example 4 Group, and Comparative Example 5 Group. The amount of food given, the amount of sprinkled food, and the amount of leftover food were recorded every week, and the body weight was weighed once. The model control group, the example group and the comparative example group were given high-calorie model feed, and the blank control group was given maintenance feed. Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, Comparative example 1 group, Comparative example 2 group, Comparative example 3 group, Comparative example 4 group and Comparative example 5 groups first Gavage capsaicin ester and menthol solution to rats at 2ml/kg body weight of rats, and then give rats intragastric administration of L-carnitine and conjugated linoleic acid solution at 2ml/kg rat body weight, model control The same amount of water was given to the control group and the blank control group, and the test sample was given for 6 weeks.

After the experiment, weigh the body weight, anesthetize, dissect the fat around the kidney and the testis, and weigh them to calculate the fat mass.

4. Data processing and result determination

Analysis of variance plus Q test was used for statistics. The results of the weight loss experiment are shown in Table 1.

Table 1 Effects of different formulas on weight gain, body fat and food intake of rats

The body weight gain of the embodiment group is lower than that of the model control group, and the body fat weight is lower than that of the model control group. The difference is significant, but the food intake is not significantly lower than that of the model control group. It can be determined that the test sample animal weight loss function test results positive. Although the weight gain and body fat weight of the control group are lower than those of the model group, the values are higher than those of the example group, indicating that one of the four ingredients is missing, and although the formed formula can slightly control the weight gain, its effect is far greater than that of the example group. far less than the example group.

The embodiment here does not exhaust the midpoint value of the technical scope claimed by the present invention, and also falls within the scope of the present invention.

The specific embodiments described herein are merely illustrative of the spirit of the invention. Those skilled in the art to which the present invention pertains can make various modifications or supplements to the described specific embodiments or adopt similar methods to replace them, but they will not deviate from the spirit of the present invention or go beyond the scope defined in the appended claims.

Although the present invention has been described in detail and some specific examples have been cited, it will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the present invention.

Claims (5)

1. a kind of prescription for losing weight, which is characterized in that the formula includes the following components'mass percentage：Capsiate 0.1~ 80%；Menthol 1~80%；L-cn 1~60%；Conjugated linoleic acid 1~80%.

2. a kind of prescription for losing weight according to claim 1, which is characterized in that the formula includes following mass percent Component：Capsiate 0.1~40%；Menthol 10~50%；L-cn 10~50%；Conjugated linoleic acid 15~55%.

3. a kind of prescription for losing weight according to claim 1, which is characterized in that the formula includes following mass percent Component：Capsiate 0.1~10%；Menthol 15~20%；L-cn 30~40%；Conjugated linoleic acid 30~40%.

4. a kind of prescription for losing weight according to claim 1, which is characterized in that the formula includes following mass percent Component：Capsiate 0.3~0.5%；Menthol 19~20%；L-cn 39~40%；Conjugated linoleic acid 39~40%.

5. a kind of application process of prescription for losing weight as described in claim 1, which is characterized in that the application process is：According to Prescription quality percentage weighs each component, and capsiate and menthol are dissolved in oil-based solvent, is applied to life entity, then will L-cn and conjugated linoleic acid are soluble in water, continue to be applied to life entity.