CN108245657A - A kind of anti-corona fragrant spray and preparation method thereof - Google Patents
A kind of anti-corona fragrant spray and preparation method thereof Download PDFInfo
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- CN108245657A CN108245657A CN201810145979.XA CN201810145979A CN108245657A CN 108245657 A CN108245657 A CN 108245657A CN 201810145979 A CN201810145979 A CN 201810145979A CN 108245657 A CN108245657 A CN 108245657A
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- 239000007921 spray Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 48
- 241000208296 Datura Species 0.000 claims abstract description 35
- 239000000341 volatile oil Substances 0.000 claims abstract description 31
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims abstract description 30
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims abstract description 30
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims abstract description 30
- 229960002646 scopolamine Drugs 0.000 claims abstract description 30
- 239000010668 rosemary oil Substances 0.000 claims abstract description 29
- 229940058206 rosemary oil Drugs 0.000 claims abstract description 29
- 239000002904 solvent Substances 0.000 claims abstract description 28
- 235000019441 ethanol Nutrition 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims description 21
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 8
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 8
- 235000008397 ginger Nutrition 0.000 claims description 8
- 238000002137 ultrasound extraction Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 238000001256 steam distillation Methods 0.000 claims description 3
- 244000273928 Zingiber officinale Species 0.000 claims 2
- 239000008141 laxative Substances 0.000 claims 1
- 230000002475 laxative effect Effects 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 238000005507 spraying Methods 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract 1
- 241000234314 Zingiber Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 201000003152 motion sickness Diseases 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 229930003347 Atropine Natural products 0.000 description 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
- 229960000396 atropine Drugs 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 description 1
- 208000006550 Mydriasis Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003457 anti-vomiting effect Effects 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000035603 choleresis Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 235000019617 piquancy Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 210000001034 respiratory center Anatomy 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Fats And Perfumes (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Abstract
The invention discloses a kind of anti-corona fragrant spray and preparation method thereof, the anti-corona fragrant spray formulations are as follows：Hyoscine 8 10%, Rosemary Oil 6 10%, solubilizer 0.8 1.2%, ethyl alcohol 18 22%, surplus are pure water in Rhizoma Zingiberis Recens volatile oil 5 8%, datura flower, and each raw material total amount is 100%.The anti-corona fragrant spray of the present invention can be used the mode for inhaling and smelling and spraying and use, and significant effect plays anti-corona effect of refreshing oneself, and safety is without side-effects, while environment can be kept pure and fresh.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of anti-corona fragrant spray and preparation method.
Background technology
" carsick, airsick, seasick " is three kinds of cardinal symptoms of motion sickness.It is the vibration due to the vehicles, makes human body certainly
Nervous disorder is restrained, the Lymphatic Circulation of inner ear is affected, and leads to para-equlibrium, patient is in ride-on vehicles/aircraft/ship
The different degrees of symptom such as dizziness, nausea, cold perspiration, vomiting can be generated in the process, and patient's journey safety and physical and mental health are made
Influence big Cheng Dangxiang.
Have very much, such as acupoint massage for the control method of motion sickness, but due to understanding of the people to human acupoint
It is and few, it is difficult to accurately hold, so acupoint massage is not easy to promote.
Drug preventing and controlling method, it is long-distance by bus when, can take medicine prevents the generation of cinetosis symptom, but can be complete there is presently no drug
This disease is effected a radical cure entirely, has certain mitigation, but use slowly effect to carsickness there are also drug, and often have certain
Side effect.
Invention content
The purpose of the present invention is to provide a kind of significant effect, safety anti-corona fragrant spray without side-effects and its preparation sides
Method.
To achieve the above object, the present invention uses following technical scheme：
A kind of anti-corona fragrant spray, is made of the raw material of following weight percent：
Rhizoma Zingiberis Recens volatile oil 5-8%；
Hyoscine 8-10% in datura flower；
Rosemary Oil 6-10%；
Solubilizer 0.8-1.2%；
Ethyl alcohol 18-22%；
Surplus is pure water, and each raw material total amount is 100%.
Further, the anti-corona fragrant spray is made of the raw material of following weight ratio percentage：
Rhizoma Zingiberis Recens volatile oil 5%；
Hyoscine 10% in datura flower；
Rosemary Oil 8%；
Solubilizer 1%；
Ethyl alcohol 20%；
Surplus is pure water, and each raw material total amount is 100%.
The solubilizer is solubilizer SE3.
The Rhizoma Zingiberis Recens volatile oil is prepared by following methods：Ginger is dried in the shade, is crushed, according to solid-to-liquid ratio 1g: 8-
12ml adds in ethyl alcohol, and 80-100 min are extracted under the conditions of 50-60 DEG C, and filtering removal filter residue obtains Rhizoma Zingiberis Recens volatile oil, yield is
7-8%。
The volume fraction of the ethyl alcohol is 75-80%.
Hyoscine is prepared by following methods in the datura flower：Datura flower fresh flower is dried in the shade, is crushed, according to solid
Liquor ratio 1g: 8-12ml adds in the hydrochloric acid solution ultrasonic extraction 25-35min of concentration 1.5-2mol/L, is then shaken with chloroform
Extraction, recycling design, according to mass ratio 1: 250-300, by residue water dissolution, obtain hyoscine in datura flower, obtain to doing
Rate is 0.33-0.40%.
The ultrasonic extraction conditions are：Power 240-260W, frequency 35-45kHz.
The Rosemary Oil is prepared by following method：It by rosemary, dries in the shade, cuts off, according to solid-to-liquid ratio 1g: 8-
12ml adds in solvent, and 3.5-4.5h is extracted using steam distillation, collects volatile matter, as Rosemary Oil, yield for 2.0~
3.0%。
The preparation method of the anti-corona fragrant spray of the present invention is as follows：By hyoscine, rosemary in Rhizoma Zingiberis Recens volatile oil, datura flower
Essential oil, solubilizer, ethyl alcohol and pure water are placed in container, are stirred evenly, then filling, obtain the anti-corona fragrant spray, should
Spray is a kind of colourless transparent liquid, has apparent strong characteristic aromatic odor.
Appliance device used is both needed to disinfection processing in fragrant spray preparation process.
The present invention is main using hyoscine, Rosemary Oil in Rhizoma Zingiberis Recens volatile oil, datura flower using above technical scheme
Raw material prepares anti-corona fragrant spray, and raw material has safety, odor type can by gained is screened in traditional Chinese medicine medicinal herbs most in use
The features such as acceptance.
Wherein, Rhizoma Zingiberis Recens volatile oil is shogaol extract, the piquancy component in ginger alcohol extract play stimulation temperature, adjust by
The effect of body, effect of stimulation influence gastric juice and choleresis by reflex, further excite stomach intestines liver the internal organs such as pancreas
Hyperfunction, this alcohol extract can enhance the defence capability of stomach lining, play by adjusting nervous centralis and autonomic nervous function
Anti-vomiting effect.
Hyoscine in datura flower, effect is similar to atropine, and atropine is compared in mydriasis and inhibition glandular secretion effect
By force, have excitation to respiratory center, but have apparent inhibiting effect to cerebral cortex, in addition with expansion capillary, change
The effects that kind microcirculation and carsick anti-blooming ship.
Rosemary Oil stimulates smell to achieve the purpose that strengthen physiology and mental functioning, rosemary be normal by essential oil
The aromatic and inducing resuscitation substance seen is contacted with the hippocampus of Schistosomiasis control memory, participates in adjusting ability of learning and memory, stimulation smell can carry
The ability of learning and memory of high normal subjects.
Anti-corona fragrant spray provided by the invention, can be used the mode for inhaling and smelling and spraying and uses, significant effect is played and refreshed oneself
Anti-corona effect, safety is without side-effects, while environment space can be kept pure and fresh, has the characteristics that safety, odor type are acceptable,
Use easy to spread.
Specific embodiment
A kind of anti-corona fragrant spray, is made of the raw material of following weight percent：
Hyoscine 8-10%, Rosemary Oil 6-10%, solubilizer SE30.8-1.2%, second in Rhizoma Zingiberis Recens volatile oil 5-8%, datura flower
Alcohol 18-22%, surplus are pure water, and each raw material total amount is 100%.
Further, the anti-corona fragrant spray is made of the raw material of following weight ratio percentage：Rhizoma Zingiberis Recens volatile oil 5%, ocean gold
It is pure water to spend middle hyoscine 10%, Rosemary Oil 8%, solubilizer SE31%, ethyl alcohol 20%, surplus, and each raw material total amount is
100%。
Wherein, Rhizoma Zingiberis Recens volatile oil is prepared by following methods：Ginger is dried in the shade, is crushed, according to solid-to-liquid ratio 1g: 8-
12ml adds in the ethyl alcohol of volume fraction 75-80%, and 80-100 min are extracted under the conditions of 50-60 DEG C, and filtering removal filter residue obtains
Rhizoma Zingiberis Recens volatile oil, yield 7-8%.
Hyoscine is prepared by following methods in datura flower：Datura flower fresh flower is dried in the shade, is crushed, according to solid-to-liquid ratio
1g: 8-12ml adds in the hydrochloric acid solution ultrasonic extraction 25-35min of concentration 1.5-2mol/L（Power 240-260W, frequency 35-
45kHz）, then with chloroform shaking out, recycling design is to dry, according to mass ratio 1: 250-300, by residue with water-soluble
Solution, obtains hyoscine in datura flower, yield 0.33-0.40%.
Rosemary Oil is prepared by following method：It by rosemary, dries in the shade, cuts off, add according to solid-to-liquid ratio 1g: 8-12ml
Enter solvent, 3.5-4.5h is extracted using steam distillation, collect volatile matter, as Rosemary Oil, yield is 2.0~3.0%.
The preparation method of anti-corona fragrance spray is as follows：By hyoscine in Rhizoma Zingiberis Recens volatile oil, datura flower, Rosemary Oil,
Solubilizer, ethyl alcohol and pure water are placed in container, are stirred evenly, then filling, obtain the anti-corona fragrant spray.
Embodiment 1
A kind of preparation method of anti-corona fragrant spray：
1）Prepare Rhizoma Zingiberis Recens volatile oil：Ginger is dried in the shade, is crushed, the ethyl alcohol of volume fraction 75% is added according to solid-to-liquid ratio 1g: 10ml,
90 min are extracted under the conditions of 55 DEG C, filtering removal filter residue obtains Rhizoma Zingiberis Recens volatile oil；
2）Prepare hyoscine in datura flower：Datura flower fresh flower is dried in the shade, is crushed, concentration is added according to solid-to-liquid ratio 1g: 10ml
The hydrochloric acid solution ultrasonic extraction 30min of 1.8mol/L（Power 250W, frequency 40kHz）, then with chloroform shaking out, return
Solvent is received to doing, according to mass ratio 1: 275, by residue water dissolution, obtains hyoscine in datura flower；
3）Prepare Rosemary Oil：It by rosemary, dries in the shade, cuts off, solvent is added according to solid-to-liquid ratio 1g: 10ml, using vapor
Distillation extraction 4h, collects volatile matter, as Rosemary Oil；
4）Prepare anti-corona fragrant spray：It stocks up according to following weight percent：Hyoscine in Rhizoma Zingiberis Recens volatile oil 5%, datura flower
10%th, Rosemary Oil 8%, solubilizer SE3 1%, ethyl alcohol 20%, surplus are pure water, and each raw material total amount is 100%；
Hyoscine, Rosemary Oil, solubilizer and ethyl alcohol and pure water in Rhizoma Zingiberis Recens volatile oil, datura flower are placed in container,
50 DEG C and fully mixing material are heated to, are cooled to room temperature, pure water is added in and stirs and evenly mixs, liquid to be mixed is cooled to room temperature, and is filled
Dress, sealing obtain the anti-corona fragrant spray.
Embodiment 2
A kind of preparation method of anti-corona fragrant spray, is made of the raw material of following weight percent：
1）Prepare Rhizoma Zingiberis Recens volatile oil：Ginger is dried in the shade, is crushed, the ethyl alcohol of volume fraction 75% is added according to solid-to-liquid ratio 1g: 8ml,
100 min are extracted under the conditions of 50 DEG C, filtering removal filter residue obtains Rhizoma Zingiberis Recens volatile oil；
2）Prepare hyoscine in datura flower：Datura flower fresh flower is dried in the shade, is crushed, concentration is added according to solid-to-liquid ratio 1g: 8ml
The hydrochloric acid solution ultrasonic extraction 25-min of 1.5mol/L（Power 260W, frequency 45kHz）, then with chloroform shaking out,
Recycling design, according to mass ratio 1: 250, by residue water dissolution, obtains hyoscine in datura flower to doing；
3）Prepare Rosemary Oil：It by rosemary, dries in the shade, cuts off, add in solvent according to solid-to-liquid ratio 1g: 8ml, steamed using vapor
Extraction 3.5h is evaporated, collects volatile matter, as Rosemary Oil；
4）Prepare anti-corona fragrant spray：It stocks up according to following weight percent：Hyoscine in Rhizoma Zingiberis Recens volatile oil 5%, datura flower
10%th, Rosemary Oil 6%, solubilizer SE3 0.8%, ethyl alcohol 18%, surplus are pure water, and each raw material total amount is 100%；
Hyoscine, Rosemary Oil, solubilizer and ethyl alcohol and pure water in Rhizoma Zingiberis Recens volatile oil, datura flower are placed in container,
45 DEG C and fully mixing material are heated to, are cooled to room temperature, pure water is added in and stirs and evenly mixs, liquid to be mixed is cooled to room temperature, and is filled
Dress, sealing obtain the anti-corona fragrant spray.
Embodiment 3
A kind of preparation method of anti-corona fragrant spray, is made of the raw material of following weight percent：
1）Prepare Rhizoma Zingiberis Recens volatile oil：Ginger is dried in the shade, is crushed, the ethyl alcohol of volume fraction 80% is added according to solid-to-liquid ratio 1g: 12ml,
100 min are extracted under the conditions of 60 DEG C, filtering removal filter residue obtains Rhizoma Zingiberis Recens volatile oil；
2）Prepare hyoscine in datura flower：Datura flower fresh flower is dried in the shade, is crushed, concentration is added according to solid-to-liquid ratio 1g: 12ml
The hydrochloric acid solution ultrasonic extraction 35min of 2mol/L（Power 240W, frequency 35kHz）, then with chloroform shaking out, recycling
Solvent, according to mass ratio 1: 300, by residue water dissolution, obtains hyoscine in datura flower to doing；
3）Prepare Rosemary Oil：It by rosemary, dries in the shade, cuts off, solvent is added according to solid-to-liquid ratio 1g: 12ml, using vapor
Distillation extraction 4.5h, collects volatile matter, as Rosemary Oil；
4）Prepare anti-corona fragrant spray：It stocks up according to following weight percent：Hyoscine in Rhizoma Zingiberis Recens volatile oil 8%, datura flower
8%th, Rosemary Oil 10%, solubilizer SE31.2%, ethyl alcohol 22%, surplus are pure water, and each raw material total amount is 100%；
Hyoscine, Rosemary Oil, solubilizer and ethyl alcohol and pure water in Rhizoma Zingiberis Recens volatile oil, datura flower are placed in container,
55 DEG C and fully mixing material are heated to, are cooled to room temperature, pure water is added in and stirs and evenly mixs, liquid to be mixed is cooled to room temperature, and is filled
Dress, sealing obtain the anti-corona fragrant spray.
Claims (9)
1. a kind of anti-corona fragrant spray, it is characterised in that：Its raw material by following weight percent forms：
Rhizoma Zingiberis Recens volatile oil 5-8%；
Hyoscine 8-10% in datura flower；
Rosemary Oil 6-10%；
Solubilizer 0.8-1.2%；
Ethyl alcohol 18-22%；
Surplus is pure water, and each raw material total amount is 100%.
2. the anti-corona fragrant spray of one kind according to claim 1, it is characterised in that：Its original by following weight ratio percentage
Material composition：
Rhizoma Zingiberis Recens volatile oil 5%；
Hyoscine 10% in datura flower；
Rosemary Oil 8%；
Solubilizer 1%；
Ethyl alcohol 20%；
Surplus is pure water, and each raw material total amount is 100%.
3. the anti-corona fragrant spray of one kind according to claim 1, it is characterised in that：The solubilizer is solubilizer SE3.
4. the anti-corona fragrant spray of one kind according to claim 1, it is characterised in that：The Rhizoma Zingiberis Recens volatile oil is by with lower section
Method is prepared：Ginger is dried in the shade, is crushed, ethyl alcohol is added according to solid-to-liquid ratio 1g: 8-12ml, 80-100 is extracted at 50-60 DEG C
Min, filtering removal filter residue, obtains Rhizoma Zingiberis Recens volatile oil.
5. the anti-corona fragrant spray of one kind according to claim 4, it is characterised in that：The volume fraction of the ethyl alcohol is 75-
80%。
6. the anti-corona fragrant spray of one kind according to claim 1, it is characterised in that：In the datura flower hyoscine be by
Following methods are prepared：Datura flower fresh flower is dried in the shade, is crushed, concentration 1.5-2mol/L is added according to solid-to-liquid ratio 1g: 8-12ml
Hydrochloric acid solution ultrasonic extraction 25-35min, then with chloroform shaking out, recycling design is to dry, according to mass ratio 1:
250-300 by residue water dissolution, obtains hyoscine in datura flower.
7. the anti-corona fragrant spray of one kind according to claim 6, it is characterised in that：The ultrasonic extraction conditions are：Power
240-260W, frequency 35-45kHz.
8. the anti-corona fragrant spray of one kind according to claim 1, it is characterised in that：The Rosemary Oil is by with laxative remedy
It is prepared：It by rosemary, dries in the shade, cuts off, add in solvent according to solid-to-liquid ratio 1g: 8-12ml, extracted using steam distillation
3.5-4.5h collects volatile matter, as Rosemary Oil.
9. a kind of preparation method of anti-corona fragrant spray as described in one of claim 1-8, it is characterised in that：Ginger is volatilized
Hyoscine, Rosemary Oil, solubilizer, ethyl alcohol and pure water are placed in container in oil, datura flower, are stirred evenly, are then filled
Dress obtains the anti-corona fragrant spray.
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| CN201810145979.XA CN108245657A (en) | 2018-02-12 | 2018-02-12 | A kind of anti-corona fragrant spray and preparation method thereof |
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| CN201810145979.XA CN108245657A (en) | 2018-02-12 | 2018-02-12 | A kind of anti-corona fragrant spray and preparation method thereof |
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| US20020100185A1 (en) * | 2000-09-24 | 2002-08-01 | Sitz Richard G. | Drying method for selectively removing volatile components from wet coatings |
| CN101780061A (en) * | 2010-03-24 | 2010-07-21 | 朱秀青 | Nasal spray |
| CN103585662A (en) * | 2013-11-13 | 2014-02-19 | 东莞市日友汽车用品有限公司 | Perfume and preparation method thereof |
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Application publication date: 20180706 |