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CN108220161B - Laboratory layout scheme for multi-cell preparation - Google Patents

Laboratory layout scheme for multi-cell preparation Download PDF

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CN108220161B
CN108220161B CN201810065997.7A CN201810065997A CN108220161B CN 108220161 B CN108220161 B CN 108220161B CN 201810065997 A CN201810065997 A CN 201810065997A CN 108220161 B CN108220161 B CN 108220161B
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曹毓琳
赵斌
时兆田
白志惠
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Beijing Tangyihuikang Biomedical Technology Co ltd
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Abstract

The invention discloses a layout scheme of a multicellular preparation laboratory, which comprises a core preparation area, wherein a quality control area, a special sample preparation area, a third visiting corridor and a cargo area are respectively arranged on the periphery of the core preparation area; a first visiting corridor is arranged between the core preparation area and the quality control area, and a second visiting corridor is arranged between the core preparation area and the special sample preparation area; the third visiting corridor is communicated with the first visiting corridor and the second visiting corridor respectively; the cargo area is located between the first and second viewing corridors; a multifunctional display hall is arranged on one side of the cargo area opposite to the core preparation area; the multifunctional exhibition hall is adjacent to the special sample preparation area, the second visit corridor, the first visit corridor and the quality control area; the relative both sides in multi-functional show room are equipped with the stair.

Description

一种多细胞制备实验室布局方案A multi-cell preparation laboratory layout scheme

技术领域technical field

本发明属于建筑设计领域;具体涉及一种多细胞制备实验室布局方案。The invention belongs to the field of architectural design, and particularly relates to a layout scheme of a multi-cell preparation laboratory.

背景技术Background technique

随着我国科技的提高,细胞制备技术也随之提高,细胞制备用于广泛的领域;如药物研究开发,如新药筛选,疫苗、基因工程药物、细胞工程药物研究与开发、单克隆抗体制备等;基础研究,如药物作用机理、基因功能、疾病发生机理等研究;生物制药,如疫苗生产:如病毒性疫苗(肝炎病毒疫苗、艾滋病疫苗等),多肽疫苗肿瘤疫苗)等;基因工程药物生产:如EPO等;抗体药物、基因治疗药物生产;细胞工程药物生产:生物细胞内的一些生物活性多肽,生物活性物质等;利用细胞法体外测定生物活性物质的活性;并预测其在体内的药效和替代体内法检测其成品的生物活性;然而细胞制备实验室需要很高的要求,细胞制备实验室,有主实验室、辅助房间、隔离装置组成,其主实验室也称核心区的环境要求:洁净级别、换气次数、相对大气的最小压差、与室外方向上相邻相通房间的最小压差Pa、温湿度、噪声、平均照度、围护结构的严密性,国家标准(GB50346-2011)均有明确标准要求;这些房间和隔离装置需要合理的布局,才能提高工作效率;现有技术的布局杂乱无章,各功能房间与隔离装置之间的相对位置随意布局,无法满足微细胞实验的工作流程和环境要求。With the improvement of science and technology in China, the cell preparation technology has also improved, and cell preparation is used in a wide range of fields; such as drug research and development, such as new drug screening, vaccines, genetic engineering drugs, cell engineering drug research and development, monoclonal antibody preparation, etc. ;Basic research, such as drug action mechanism, gene function, disease mechanism, etc.; biopharmaceuticals, such as vaccine production: such as viral vaccines (hepatitis virus vaccine, AIDS vaccine, etc.), polypeptide vaccine tumor vaccine), etc.; genetic engineering drug production : such as EPO, etc.; production of antibody drugs and gene therapy drugs; production of cell engineering drugs: some biologically active polypeptides, biologically active substances in biological cells, etc.; using cell method to measure the activity of biologically active substances in vitro; However, the cell preparation laboratory requires high requirements. The cell preparation laboratory consists of the main laboratory, auxiliary rooms, and isolation devices. The main laboratory is also called the environment of the core area. Requirements: cleanliness level, number of air changes, minimum pressure difference relative to the atmosphere, minimum pressure difference Pa between adjacent rooms in the outdoor direction, temperature and humidity, noise, average illuminance, tightness of the enclosure, national standard (GB50346- 2011) have clear standard requirements; these rooms and isolation devices need a reasonable layout to improve work efficiency; the layout of the existing technology is disorganized, and the relative positions between each functional room and the isolation device are randomly arranged, which cannot meet the requirements of microcell experiments. Workflow and environmental requirements.

发明内容SUMMARY OF THE INVENTION

为了解决现有技术中存在的问题,本发明提供一种多细胞制备实验室布局方案。In order to solve the problems existing in the prior art, the present invention provides a multi-cell preparation laboratory layout scheme.

本发明具体技术方案如下:The specific technical scheme of the present invention is as follows:

一种多细胞制备实验室布局方案,包括核心制备区,所述核心制备区四周分别设有质量控制区、特殊样本制备区、第三参观走廊和货物区;所述核心制备区与所述质量控制区之间设有第一参观走廊,所述核心制备区与所述特殊样本制备区之间设有第二参观走廊;所述第三参观走廊分别与所述第一参观走廊和第二参观走廊连通;所述货物区位于所述第一参观走廊和所述第二参观走廊之间;所述货物区与所述核心制备区相对的一侧设有多功能展示厅;所述多功能展示厅与所述特殊样本制备区、所述第二参观走廊、所述第一参观走廊和质量控制区均相邻;所述多功能展示厅相对两侧设有楼梯。A layout plan for a multi-cell preparation laboratory, including a core preparation area surrounded by a quality control area, a special sample preparation area, a third visit corridor and a cargo area; the core preparation area and the quality A first visiting corridor is set between the control areas, a second visiting corridor is set between the core preparation area and the special sample preparation area; the third visiting corridor is respectively connected with the first visiting corridor and the second visiting corridor The corridor is connected; the cargo area is located between the first visiting corridor and the second visiting corridor; a multi-functional exhibition hall is arranged on the opposite side of the cargo area and the core preparation area; the multi-functional exhibition The hall is adjacent to the special sample preparation area, the second visiting corridor, the first visiting corridor and the quality control area; stairs are provided on opposite sides of the multi-functional exhibition hall.

优化的,所述核心制备区包括一侧与所述第三参观走廊相邻的第一制备区、第二制备区和第三制备区;所述第一制备区相对另一侧设有第一洁净走廊;所述第二制备区和第三制备区的相对另一侧均设有第二洁净走廊;所述第一制备区与所述第二制备区之间设有与所述第一洁净走廊连通的第三洁净走廊,所述第二制备区与所述第三制备区之间设有与所述第二洁净走廊连通的第四洁净走廊;所述第一洁净走廊与所述第二洁净走廊相邻。Preferably, the core preparation area includes a first preparation area, a second preparation area and a third preparation area adjacent to the third visiting corridor on one side; the first preparation area is provided with a first preparation area on the opposite side. A clean corridor; the opposite sides of the second preparation area and the third preparation area are provided with a second clean corridor; between the first preparation area and the second preparation area a third clean corridor connected by a corridor, a fourth clean corridor connected with the second clean corridor is arranged between the second preparation area and the third preparation area; the first clean corridor is connected to the second clean corridor Clean corridors are adjacent.

优化的,所述第一制备区内部从第三参观走廊到第一洁净走廊的方向依次设有与所述第二参观走廊相邻的第一免疫细胞培养室、第三免疫细胞制备室、第二免疫细胞培养室、第四免疫细胞制备室、第一更衣室、第二更衣室和免疫细胞样本接受室;所述第一免疫细胞培养室远离所述第二参观走廊的一侧设有与所述第三免疫细胞制备室相邻的第一免疫细胞离心室;所述第二免疫细胞制备室远离所述第二参观走廊的一侧设有与所述第三免疫细胞制备室和所述第四免疫细胞制备室均相邻的第二免疫细胞离心室;所述第一更衣室远离所述第二参观走廊的一侧依次设有第一缓冲区和第二缓冲区,所述第一缓冲区与所述第四免疫细胞制备室相邻,所述第二缓冲区与第二更衣室相邻;所述免疫细胞样本接受室远离所述第二参观走廊的一侧设有与所述第二更衣室和所述第一洁净走廊均相邻的第一退更室。Preferably, the first preparation area is provided with a first immune cell culture room, a third immune cell preparation room, a third immune cell preparation room adjacent to the second visit corridor in order from the third visiting corridor to the first clean corridor. Two immune cell culture rooms, a fourth immune cell preparation room, a first dressing room, a second dressing room and an immune cell sample receiving room; the side of the first immune cell culture room away from the second visiting corridor is provided with The third immune cell preparation room is adjacent to the first immune cell centrifuge room; the side of the second immune cell preparation room away from the second visiting corridor is provided with the third immune cell preparation room and the The fourth immune cell preparation chambers are adjacent to the second immune cell centrifuge chamber; the side of the first dressing room away from the second visiting corridor is sequentially provided with a first buffer zone and a second buffer zone. The buffer area is adjacent to the fourth immune cell preparation room, and the second buffer area is adjacent to the second dressing room; the immune cell sample receiving room is provided with the The second changing room and the first changing room are adjacent to the first clean corridor.

优化的,所述第二制备区内部从第三参观走廊到第二洁净走廊的方向依次设有与所述第三洁净走廊相邻的第一废弃物出口、第一气瓶间、程控降温室、干细胞培养及制剂发放室、干细胞培养室、脐带干细胞制备室和脐带血细胞制备室;所述第一废弃物出口远离所述第三洁净走廊一侧设有第二废弃物出口;所述第一气瓶间远离所述第三洁净走廊一侧设有第二气瓶间;所述第二气瓶间两侧分别与所述第二废弃物出口和所述程控降温室相邻;所述干细胞培养室远离所述第三洁净走廊一侧设有与其相邻的干细胞离心室;所述干细胞离心室两侧分别与所述干细胞培养及制剂发放室和所述脐带干细胞制备室相邻;所述第一废弃物出口和所述第一气瓶间之间设有短走廊,所述短走廊另一侧与所述第二废弃物出口和所述第二气瓶间相邻。Preferably, the second preparation area is provided with a first waste outlet, a first gas cylinder room, and a program-controlled cooling room adjacent to the third clean corridor in the direction from the third visit corridor to the second clean corridor. , stem cell culture and preparation distribution room, stem cell culture room, umbilical cord stem cell preparation room and umbilical cord blood cell preparation room; the first waste outlet is provided with a second waste outlet on the side away from the third clean corridor; the first waste outlet A second gas cylinder room is arranged between the gas cylinders on the side away from the third clean corridor; the two sides of the second gas cylinder room are respectively adjacent to the second waste outlet and the program-controlled cooling chamber; the stem cells A stem cell centrifuge room adjacent to the culture room is provided on one side away from the third clean corridor; the two sides of the stem cell centrifuge room are respectively adjacent to the stem cell culture and preparation distribution room and the umbilical cord stem cell preparation room; the A short corridor is arranged between the first waste outlet and the first gas cylinder, and the other side of the short corridor is adjacent between the second waste outlet and the second gas cylinder.

优化的,所述第三制备区内部从第三参观走廊到第二洁净走廊的方向依次设有与所述第四洁净走廊相邻的胎盘血细胞制备室、离心室、成人脂肪干细胞制备室、培养室、第三缓冲区、第四缓冲区、第三更衣室、第二退更室;所述第三缓冲区远离所述第四洁净走廊的一侧设有与所述第三缓冲区和第四缓冲区均相邻的第四更衣室,所述第四更衣室两侧分别与所述培养室和所述第三更衣室均相邻;所述第二退更室远离所述第四洁净走廊的一侧设有与其相邻的干细胞样本接收室;所述干细胞样本接收室两侧分别与所述第三更衣室和第二洁净走廊相邻。Optimized, inside the third preparation area, there are placental blood cell preparation room, centrifuge room, adult adipose stem cell preparation room, culture room adjacent to the fourth clean corridor in order from the third visiting corridor to the second clean corridor. room, a third buffer zone, a fourth buffer zone, a third dressing room, and a second retreat room; the side of the third buffer zone away from the fourth clean corridor is provided with the third buffer zone and the third buffer zone. A fourth changing room with four buffer zones adjacent to each other, the fourth changing room is adjacent to the culture room and the third changing room on both sides respectively; the second changing room is far away from the fourth clean room One side of the corridor is provided with a stem cell sample receiving room adjacent thereto; two sides of the stem cell sample receiving room are respectively adjacent to the third changing room and the second clean corridor.

优化的,所述特殊样本制备区延所述第二参观走廊长度方向依次设有相邻的工作细胞库、第五更衣室、第六更衣室、第五洁净走廊、阳性离心室、阳性制备培养室、第三废弃物出口、第一过度室、第二过度室、样本总接收室和收样外室;所述第五更衣室远离所述第二参观走廊一侧设有与其相邻的第三退更室,所述第三退更室与所述工作细胞库相邻;所述第六更衣室远离所述第二参观走廊一侧依次设有与其相邻的第五缓冲室和第六缓冲室;所述第一过度室远离所述第二参观走廊一侧设有与所述第一过度室和所述第二过度室均相邻的第一洁净物料库;所述收样外室远离所述第二参观走廊一侧依次设有与其相邻的废弃物暂存室;所述第三退更室与所述第一洁净物料库之间设有第五洁净走廊,所述第五洁净走廊与所述第五缓冲室、第六缓冲室、阳性离心室和阳性制备培养室均相邻;所述第五洁净走廊设有两个分支走廊,其一所述分支走廊处于所述第六更衣室和阳性离心室之间;另一所述分支走廊处于所述阳性制备培养室和所述第一洁净物料库之间且与所述第三废弃物出口相邻;所述第三废弃物出口与所述阳性制备培养室相邻处设有双扉传递窗。Optimized, the special sample preparation area is provided with adjacent working cell banks, fifth dressing room, sixth dressing room, fifth clean corridor, positive centrifuge room, and positive preparation culture in sequence along the length of the second visiting corridor. room, the third waste outlet, the first transition room, the second transition room, the total sample receiving room, and the outer sample receiving room; the fifth changing room is provided with a No. 1 adjacent to it on the side away from the second visiting corridor. Three changing rooms, the third changing room is adjacent to the working cell bank; the sixth changing room is provided with a fifth buffer room and a sixth changing room adjacent to the sixth changing room on the side away from the second visiting corridor. a buffer room; a first clean material warehouse adjacent to both the first transition room and the second transition room is provided on the side of the first transition room away from the second visiting corridor; the sample collection outer room A waste temporary storage room adjacent to the second visiting corridor is arranged in sequence; a fifth clean corridor is arranged between the third change room and the first clean material warehouse, and the fifth The clean corridor is adjacent to the fifth buffer room, the sixth buffer room, the positive centrifuge room and the positive preparation culture room; the fifth clean corridor is provided with two branch corridors, one of the branch corridors is located in the first Six between the dressing room and the positive centrifuge room; the other branch corridor is between the positive preparation culture room and the first clean material warehouse and adjacent to the third waste outlet; the third waste There is a double-doored transfer window adjacent to the material outlet and the positive preparation culture chamber.

优化的,所述质量控制区延所述第一参观走廊长度方向依次设有相邻的理化室、流式细胞室、微生物培养室、第七缓冲室、样本接收室、第八缓冲室、样本接收室、清洁室和洗消室;所述样本接收室远离所述第一参观走廊一侧设有与其相邻的冷冻室;所述第七缓冲室处于所述微生物培养室拐角处且与所述第一参观走廊和所述样本接收室均相邻;所述第八缓冲室处于所述样本接收室拐角处且与所述第一参观走廊和所述样本接收室均相邻。Preferably, the quality control area is provided with adjacent physical and chemical chambers, flow cytometry chambers, microorganism culture chambers, seventh buffer chambers, sample receiving chambers, eighth buffer chambers, samples in sequence along the length of the first visiting corridor A receiving room, a cleaning room and a decontamination room; the sample receiving room is provided with a freezing room adjacent to it on the side away from the first visiting corridor; the seventh buffer room is located at the corner of the microorganism culture room and is connected to the The first visiting corridor and the sample receiving chamber are adjacent; the eighth buffer chamber is located at the corner of the sample receiving chamber and is adjacent to both the first visiting corridor and the sample receiving chamber.

优化的,所述货物区内部从所述第一洁净走廊到所述第二洁净走廊的方向依次设有与所述多功能展示厅相邻的第一物料入口、第二洁净物料库、第三洁净物料库和第二物料入口;所述第一物料入口与所述第一洁净走廊和所述第二洁净物料库相邻处均设有双扉传递窗;所述第二物料入口与所述第二洁净走廊和所述第三洁净物料库相邻处均设有双扉传递窗。Preferably, a first material entrance, a second clean material warehouse, a third A clean material storehouse and a second material entrance; the first material entrance and the first clean corridor and the second clean material storehouse are provided with double-doored transfer windows; the second material entrance is connected to the The second clean corridor and the adjacent part of the third clean material storehouse are provided with double-leaf transfer windows.

优化的,所述第一洁净走廊与所述第二洁净走廊相邻处设有紧急疏散逃离窗;所述第一洁净走廊与所述第二参观走廊相邻处设有紧急疏散逃离窗;所述第二洁净走廊与所述第一参观走廊相邻处设有紧急疏散逃离窗;所述第三洁净走廊与所述第三参观走廊相邻且相邻处设有紧急疏散观察窗;所述第四洁净走廊与所述第三参观走廊相邻且相邻处设有紧急疏散观察窗。Preferably, an emergency evacuation escape window is provided adjacent to the first clean corridor and the second clean corridor; an emergency evacuation escape window is provided adjacent to the first clean corridor and the second visiting corridor; There is an emergency evacuation escape window adjacent to the second clean corridor and the first visiting corridor; the third clean corridor is adjacent to the third visiting corridor and is provided with an emergency evacuation observation window; the The fourth clean corridor is adjacent to the third visiting corridor, and an emergency evacuation observation window is arranged adjacent thereto.

优化的,所述多功能展示厅远离所述货物区一侧的两端设有进出楼梯。Preferably, two ends of the multi-functional exhibition hall on the side away from the cargo area are provided with access stairs.

本发明的有益效果如下:本发明提供的一种多细胞制备实验室布局方案具有人流、物流、污物流清晰,安全性能好,物流合理,生产作业更方便,设计符合标准、规范,可满足临床、诊断、参观教学和研究的实验室,安全可靠、节能减排,对生物实验室工程建设,具有一定的指导意义。The beneficial effects of the present invention are as follows: the multi-cell preparation laboratory layout scheme provided by the present invention has the advantages of clear flow of people, logistics, and waste, good safety performance, reasonable logistics, more convenient production operations, and the design conforms to standards and specifications, and can meet clinical needs. It is safe, reliable, energy saving and emission reduction, which has certain guiding significance for the construction of biological laboratory engineering.

附图说明Description of drawings

图1为本发明提供的一种多细胞制备实验室布局方案的整体图;1 is an overall diagram of a multi-cell preparation laboratory layout scheme provided by the present invention;

图2为本发明提供的一种多细胞制备实验室布局方案的核心制备区布局图;2 is a layout diagram of a core preparation area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图3为本发明提供的一种多细胞制备实验室布局方案的第一制备区布局图;3 is a layout diagram of a first preparation area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图4为本发明提供的一种多细胞制备实验室布局方案的第二制备区布局图;4 is a layout diagram of a second preparation area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图5为本发明提供的一种多细胞制备实验室布局方案的第三制备区布局图;5 is a layout diagram of a third preparation area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图6为本发明提供的一种多细胞制备实验室布局方案的特殊样本制备区布局图;6 is a layout diagram of a special sample preparation area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图7为本发明提供的一种多细胞制备实验室布局方案的质量控制区布局图;7 is a layout diagram of a quality control area of a multi-cell preparation laboratory layout scheme provided by the present invention;

图8为本发明提供的一种多细胞制备实验室布局方案的货物区布局图。FIG. 8 is a layout diagram of the cargo area of a multi-cell preparation laboratory layout scheme provided by the present invention.

具体实施方式Detailed ways

下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

实施例1Example 1

请参阅图1所示,本发明提供一种多细胞制备实验室布局方案,包括核心制备区7,所述核心制备区7四周分别设有质量控制区5、特殊样本制备区8、第三参观走廊6和货物区3;所述核心制备区7与所述质量控制区5之间设有第一参观走廊4,所述核心制备区7与所述特殊样本制备区8之间设有第二参观走廊2;所述第三参观走廊6分别与所述第一参观走廊4和第二参观走廊2连通;所述货物区3位于所述第一参观走廊4和所述第二参观走廊2之间;所述货物区3与所述核心制备区7相对的一侧设有多功能展示厅1;所述多功能展示厅1与所述特殊样本制备区8、所述第二参观走廊2、所述第一参观走廊4和质量控制区5均相邻;所述多功能展示厅1相对两侧设有楼梯。Please refer to FIG. 1 , the present invention provides a multi-cell preparation laboratory layout plan, including a core preparation area 7, and the core preparation area 7 is provided with a quality control area 5, a special sample preparation area 8, and a third visit area around the core preparation area 7 respectively. Corridor 6 and cargo area 3; between the core preparation area 7 and the quality control area 5 there is a first visit corridor 4, between the core preparation area 7 and the special sample preparation area 8 there is a second Visiting corridor 2; the third visiting corridor 6 communicates with the first visiting corridor 4 and the second visiting corridor 2 respectively; the cargo area 3 is located between the first visiting corridor 4 and the second visiting corridor 2 There is a multi-functional exhibition hall 1 on the opposite side of the cargo area 3 and the core preparation area 7; the multi-functional exhibition hall 1 and the special sample preparation area 8, the second visiting corridor 2, The first visiting corridor 4 and the quality control area 5 are adjacent to each other; there are stairs on opposite sides of the multi-functional exhibition hall 1 .

需要说明的是每个室均设有进出的门,若干相邻实验室相邻处设有传递窗;使用时可根据自身情况选择进入哪个实验室,如选择进入质量控制区,可选择靠近质量控制区较近的楼梯进入,第一参观走廊、第二参观走廊和第三参观走廊用于参观学习;设有的多条通道方便达到快速进入目标工作区域的作用。It should be noted that each room has an entrance and exit door, and several adjacent laboratories have transfer windows adjacent to each other; when using, you can choose which laboratory to enter according to your own situation. If you choose to enter the quality control area, you can choose to be close to the quality The stairs near the control area are used to enter, and the first visiting corridor, the second visiting corridor and the third visiting corridor are used for visiting and learning; there are multiple passages to facilitate the rapid entry into the target work area.

实施例2Example 2

进一步的,请参阅图2所示,所述核心制备区7包括一侧与所述第三参观走廊6相邻的第一制备区71、第二制备区72和第三制备区73;所述第一制备区71相对另一侧设有第一洁净走廊74;所述第二制备区72和第三制备区73的相对另一侧均设有第二洁净走廊76;所述第一制备区71与所述第二制备区72之间设有与所述第一洁净走廊74连通的第三洁净走廊75,所述第二制备区72与所述第三制备区73之间设有与所述第二洁净走廊76连通的第四洁净走廊77;所述第一洁净走廊74与所述第二洁净走廊76相邻。Further, as shown in FIG. 2 , the core preparation area 7 includes a first preparation area 71 , a second preparation area 72 and a third preparation area 73 adjacent to the third visiting corridor 6 on one side; the The opposite side of the first preparation area 71 is provided with a first clean corridor 74; the opposite sides of the second preparation area 72 and the third preparation area 73 are provided with a second clean corridor 76; the first preparation area 71 and the second preparation area 72 is provided with a third clean corridor 75 communicating with the first clean corridor 74, and between the second preparation area 72 and the third preparation area 73 The second clean corridor 76 is connected to a fourth clean corridor 77 ; the first clean corridor 74 is adjacent to the second clean corridor 76 .

使用时可根据自身情况选择进入哪个实验室,如选择核心制备区的第一制备区,可选择靠近第一制备区的楼梯进入到多功能展示厅,通过多功能展示厅后进入第二参观走廊,可通过第二参观走廊进入第一制备区内部。When using, you can choose which laboratory to enter according to your own situation. For example, if you choose the first preparation area of the core preparation area, you can choose the stairs close to the first preparation area to enter the multi-functional exhibition hall, and enter the second visiting corridor after passing through the multi-functional exhibition hall. , you can enter the interior of the first preparation area through the second visiting corridor.

实施例3Example 3

进一步的,请参阅图3所示,所述第一制备区71内部从第三参观走廊6到第一洁净走廊74的方向依次设有与所述第二参观走廊2相邻的第一免疫细胞培养室711、第三免疫细胞制备室712、第二免疫细胞培养室713、第四免疫细胞制备室714、第一更衣室715、第二更衣室718和免疫细胞样本接受室716;所述第一免疫细胞培养室711远离所述第二参观走廊2的一侧设有与所述第三免疫细胞制备室712相邻的第一免疫细胞离心室7112;所述第二免疫细胞制备室713远离所述第二参观走廊2的一侧设有与所述第三免疫细胞制备室712和所述第四免疫细胞制备室714均相邻的第二免疫细胞离心室7111;所述第一更衣室715远离所述第二参观走廊2的一侧依次设有第一缓冲区7110和第二缓冲区719,所述第一缓冲区7110与所述第四免疫细胞制备室714相邻,所述第二缓冲区719与第二更衣室718相邻;所述免疫细胞样本接受室716远离所述第二参观走廊2的一侧设有与所述第二更衣室718和所述第一洁净走廊74均相邻的第一退更室717。Further, please refer to FIG. 3 , the first preparation area 71 is sequentially provided with first immune cells adjacent to the second visiting corridor 2 in the direction from the third visiting corridor 6 to the first cleaning corridor 74 A culture room 711, a third immune cell preparation room 712, a second immune cell culture room 713, a fourth immune cell preparation room 714, a first dressing room 715, a second dressing room 718, and an immune cell sample receiving room 716; An immune cell culture chamber 711 is provided with a first immune cell centrifuge chamber 7112 adjacent to the third immune cell preparation chamber 712 on the side away from the second visiting corridor 2; the second immune cell preparation chamber 713 is far away from the A second immune cell centrifuge chamber 7111 adjacent to the third immune cell preparation chamber 712 and the fourth immune cell preparation chamber 714 is provided on one side of the second visiting corridor 2; the first dressing room 715 A first buffer zone 7110 and a second buffer zone 719 are arranged on the side away from the second visiting corridor 2 in sequence, and the first buffer zone 7110 is adjacent to the fourth immune cell preparation room 714. The second buffer area 719 is adjacent to the second dressing room 718; the side of the immune cell sample receiving room 716 away from the second visiting corridor 2 is provided with the second dressing room 718 and the first clean corridor 74 The first retreat chambers 717 are adjacent to each other.

使用时,首先进入第二更衣室,更换衣服、鞋子等,经过第二更衣室后进入第二缓冲区,经过第二缓冲区进入第一更衣室,进入第一更衣室,更换洁净衣物、并对手进行消毒等,经过第一更衣室进入第一缓冲区,经过第一缓冲区进入第三洁净走廊,经过第三洁净走廊进入第一制备区内的各个实验室进行工作;实验结束后经过第三洁净走廊进入第一退更室,进入退更室脱去实验服,经过退更室后从第二更衣室退出第一制备区。When using, first enter the second dressing room, change clothes, shoes, etc., enter the second buffer zone after passing through the second dressing room, enter the first dressing room through the second buffer zone, enter the first dressing room, change clean clothes, and Hands are disinfected, etc., enter the first buffer zone through the first dressing room, enter the third clean corridor through the first buffer zone, and enter each laboratory in the first preparation area through the third clean corridor for work; The three clean corridors enter the first locker room, enter the locker room to take off the lab coat, and exit the first preparation area from the second locker room after passing through the locker room.

实施例4Example 4

进一步的,请参阅图4所示,所述第二制备区72内部从第三参观走廊6到第二洁净走廊76的方向依次设有与所述第三洁净走廊75相邻的第一废弃物出口726、第一气瓶间725、程控降温室724、干细胞培养及制剂发放室728、干细胞培养室723、脐带干细胞制备室722和脐带血细胞制备室721;所述第一废弃物出口726远离所述第三洁净走廊75一侧设有第二废弃物出口7210;所述第一气瓶间725远离所述第三洁净走廊75一侧设有第二气瓶间729;所述第二气瓶间729两侧分别与所述第二废弃物出口7210和所述程控降温室724相邻;所述干细胞培养室723远离所述第三洁净走廊75一侧设有与其相邻的干细胞离心室727;所述干细胞离心室727两侧分别与所述干细胞培养及制剂发放室728和所述脐带干细胞制备室722相邻;所述第一废弃物出口726和所述第一气瓶间725之间设有短走廊,所述短走廊另一侧与所述第二废弃物出口726和所述第二气瓶间729相邻。Further, please refer to FIG. 4 , the second preparation area 72 is sequentially provided with first wastes adjacent to the third clean corridor 75 in the direction from the third visiting corridor 6 to the second clean corridor 76 . Exit 726, first gas cylinder room 725, program-controlled cooling room 724, stem cell culture and preparation distribution room 728, stem cell culture room 723, umbilical cord stem cell preparation room 722, and cord blood cell preparation room 721; the first waste outlet 726 is far away from the A second waste outlet 7210 is provided on one side of the third clean corridor 75; a second gas cylinder room 729 is provided on the side of the first gas cylinder 725 away from the third clean corridor 75; the second gas cylinder The two sides of the room 729 are respectively adjacent to the second waste outlet 7210 and the program-controlled cooling chamber 724; the stem cell culture chamber 723 is provided with an adjacent stem cell centrifuge chamber 727 on the side away from the third clean corridor 75. The stem cell centrifuge chamber 727 is adjacent to the stem cell culture and preparation distribution chamber 728 and the umbilical cord stem cell preparation chamber 722 on both sides respectively; between the first waste outlet 726 and the first gas cylinder 725 A short corridor is provided, and the other side of the short corridor is adjacent to the second waste outlet 726 and the second gas cylinder room 729 .

使用时可根据自身情况选择进入哪个实验室,如选择核心制备区的第二制备区;选择合适的楼梯进入到多功能展示厅,经过多功能展示厅后进入第一参观走廊,经过第一参观走廊进入第三制备区,通过第三制备区进入第四洁净走廊,经过第四洁净走廊分别进入第二制备区的各个实验室进行工作;在第二制备区产生的废弃物可通过第四洁净走廊运输到第二废弃物出口处进行处理;实验结束后,经过第四洁净走廊进入第二洁净走廊,经过第二洁净走廊进入第三制备区,经过第三制备区退出核心制备区;第一制备区产生的废弃物可通过第三洁净走廊运输到第一废弃物出口处理。When using, you can choose which laboratory to enter according to your own situation, such as choosing the second preparation area of the core preparation area; choose the appropriate stairs to enter the multi-functional exhibition hall, enter the first visiting corridor after passing through the multi-functional exhibition hall, and pass the first visit The corridor enters the third preparation area, enters the fourth clean corridor through the third preparation area, and enters each laboratory in the second preparation area through the fourth clean corridor for work; the waste generated in the second preparation area can pass through the fourth clean corridor. The corridor is transported to the second waste exit for processing; after the experiment is over, enter the second clean corridor through the fourth clean corridor, enter the third preparation area through the second clean corridor, and exit the core preparation area through the third preparation area; the first The waste generated in the preparation area can be transported to the first waste outlet for processing through the third clean corridor.

实施例5Example 5

进一步的,请参阅图5所示,所述第三制备区73内部从第三参观走廊6到第二洁净走廊76的方向依次设有与所述第四洁净走廊77相邻的胎盘血细胞制备室731、离心室732、成人脂肪干细胞制备室733、培养室734、第三缓冲区7310、第四缓冲区739、第三更衣室737、第二退更室738;所述第三缓冲区7310远离所述第四洁净走廊77的一侧设有与所述第三缓冲区7310和第四缓冲区739均相邻的第四更衣室735,所述第四更衣室735两侧分别与所述培养室734和所述第三更衣室737均相邻;所述第二退更室738远离所述第四洁净走廊77的一侧设有与其相邻的干细胞样本接收室736;所述干细胞样本接收室736两侧分别与所述第三更衣室737和第二洁净走廊76相邻。Further, as shown in FIG. 5 , a placental blood cell preparation room adjacent to the fourth clean corridor 77 is arranged in the third preparation area 73 from the third visiting corridor 6 to the second clean corridor 76 in sequence. 731, centrifugation chamber 732, adult adipose stem cell preparation chamber 733, culture chamber 734, third buffer zone 7310, fourth buffer zone 739, third changing room 737, second changing room 738; the third buffer zone 7310 is far away One side of the fourth clean corridor 77 is provided with a fourth dressing room 735 adjacent to both the third buffer zone 7310 and the fourth buffer zone 739, and two sides of the fourth dressing room 735 are respectively connected to the culture The room 734 and the third changing room 737 are adjacent to each other; the side of the second retreat room 738 away from the fourth clean corridor 77 is provided with a stem cell sample receiving room 736 adjacent to it; the stem cell sample receiving room 736 is adjacent to it; Two sides of the room 736 are adjacent to the third changing room 737 and the second clean corridor 76 respectively.

使用时,从楼梯进入到多功能展示厅,经过多功能展示厅后进入第一参观走廊,通过第一参观走廊依次进入第三更衣室、第四缓冲区、第四更衣室和第三缓冲区,然后通过第四洁净走廊进入需要进行试验的目标实验室;实验完成后,通过第四洁净走廊进入第二洁净走廊,经过第二洁净走廊进入第二退更室脱去实验服,经过退更室进入第三更衣室,经过第三更衣室进入第一参观走廊。When in use, enter the multi-functional exhibition hall from the stairs, enter the first visiting corridor after passing through the multi-functional exhibition hall, and enter the third dressing room, the fourth buffer zone, the fourth dressing room and the third buffer zone in sequence through the first visiting corridor. , and then enter the target laboratory that needs to be tested through the fourth clean corridor; after the experiment is completed, enter the second clean corridor through the fourth clean corridor, and enter the second change room through the second clean corridor. The room enters the third dressing room, and passes through the third dressing room to enter the first visiting corridor.

实施例6Example 6

进一步的,请参阅图6所示,所述特殊样本制备区8延所述第二参观走廊2长度方向依次设有相邻的工作细胞库81、第五更衣室88、第六更衣室811、第五洁净走廊83、阳性离心室812、阳性制备培养室813、第三废弃物出口817、第一过度室816、第二过度室815、样本总接收室85和收样外室814;所述第五更衣室88远离所述第二参观走廊2一侧设有与其相邻的第三退更室82,所述第三退更室82与所述工作细胞库81相邻;所述第六更衣室811远离所述第二参观走廊2一侧依次设有与其相邻的第五缓冲室89和第六缓冲室810;所述第一过度室816远离所述第二参观走廊2一侧设有与所述第一过度室816和所述第二过度室815均相邻的第一洁净物料库84;所述收样外室814远离所述第二参观走廊2一侧依次设有与其相邻的废弃物暂存室86;所述第三退更室82与所述第一洁净物料库84之间设有第五洁净走廊83,所述第五洁净走廊83与所述第五缓冲室89、第六缓冲室810、阳性离心室812和阳性制备培养室813均相邻;所述第五洁净走廊83设有两个分支走廊,其一所述分支走廊处于所述第六更衣室811和阳性离心室812之间;另一所述分支走廊处于所述阳性制备培养室813和所述第一洁净物料库84之间且与所述第三废弃物出口817相邻;所述第三废弃物出口817与所述阳性制备培养室813相邻处设有双扉传递窗。Further, please refer to FIG. 6 , the special sample preparation area 8 is provided with adjacent working cell banks 81 , a fifth dressing room 88 , a sixth dressing room 811 , a working cell bank 81 , a fifth dressing room 88 , a sixth dressing room 811 , The fifth clean corridor 83, the positive centrifuge room 812, the positive preparation culture room 813, the third waste outlet 817, the first transition room 816, the second transition room 815, the general sample receiving room 85, and the outer sample receiving room 814; the A third changing room 82 adjacent to the fifth changing room 88 is arranged on the side away from the second visiting corridor 2, and the third changing room 82 is adjacent to the working cell bank 81; the sixth changing room 82 is adjacent to the working cell bank 81; The dressing room 811 is provided with a fifth buffer room 89 and a sixth buffer room 810 on the side away from the second visiting corridor 2 in sequence; There is a first clean material warehouse 84 adjacent to both the first transition room 816 and the second transition room 815 ; the sample collection outer room 814 is provided with a side of the sample collection outer room 814 away from the second visiting corridor 2 in turn. The adjacent waste temporary storage room 86; a fifth clean corridor 83 is arranged between the third change room 82 and the first clean material warehouse 84, the fifth clean corridor 83 and the fifth buffer room 89. The sixth buffer chamber 810 , the positive centrifuge chamber 812 and the positive preparation culture chamber 813 are all adjacent to each other; the fifth clean corridor 83 is provided with two branch corridors, one of which is located in the sixth dressing room 811 and the positive centrifuge chamber 812; the other branch corridor is located between the positive preparation and cultivation chamber 813 and the first clean material storehouse 84 and is adjacent to the third waste outlet 817; the third The waste outlet 817 is provided with a double-leafed transfer window adjacent to the positive preparation incubation chamber 813 .

需要说明的是每个室均设有进出的门使用时可根据自身情况选择进入哪个实验室,如需要制备培养阳性细胞,可从多功能展厅靠近特殊样本制备区的楼梯口进入到多功能展厅内,经过多功能展厅后进入第二参观走廊,从第二参观走廊进入第五更衣室,经过第五更衣室后在进入第五缓冲室,经过第五缓冲室后在进入第六更衣室,经过第六更衣室后在进入第六缓冲室,经过第六缓冲室在进入第五洁净走廊,从第五洁净走廊可分别进入阳性离心室、阳性制备培养室和洁净物料库;在阳性制备培养室中工作时产生的废弃物可从两者相邻处之间设有的双扉传递窗送入第三废弃物出口内,然后有工作人员从第二参观走廊到第三参观走廊将第一废弃物出口、第二费废弃物出口,第三废弃物出口的废弃物经过多功能展示厅运输到废弃物暂存处;取物料时工作人员可从第五洁净走廊进入第一洁净物料库直接提取,物料通过第一过度间与分支走廊相邻处的双扉传递窗进行输送;收样外室收到的样本可通过样本总接收室与收样外室之间设置的推拉窗进行输送。It should be noted that each room is equipped with an entrance and exit door. When using, you can choose which laboratory to enter according to your own situation. If you need to prepare culture-positive cells, you can enter the multi-functional exhibition hall from the stair entrance of the multi-functional exhibition hall near the special sample preparation area. Inside, enter the second visiting corridor after passing through the multi-functional exhibition hall, enter the fifth dressing room from the second visiting corridor, enter the fifth buffer room after passing through the fifth dressing room, enter the sixth dressing room after passing through the fifth buffer room, After passing through the sixth dressing room, enter the sixth buffer room, and after passing through the sixth buffer room, enter the fifth clean corridor. From the fifth clean corridor, you can enter the positive centrifuge room, the positive preparation culture room and the clean material warehouse respectively; in the positive preparation culture The waste generated when working in the room can be sent into the third waste outlet from the double-doored transfer window provided between the two adjacent ones, and then a staff will take the first one from the second visiting corridor to the third visiting corridor. Waste exit, second fee waste exit, and third waste exit waste are transported to the temporary waste storage area through the multi-functional exhibition hall; when picking up materials, staff can enter the first clean material warehouse directly from the fifth clean corridor. For extraction, the materials are transported through the double-leafed transfer window adjacent to the first transition room and the branch corridor; the samples received in the outer sample receiving room can be transported through the sliding window set between the general sample receiving room and the outer sample receiving room.

实施例7Example 7

进一步的,请参阅图7所示,所述质量控制区5延所述第一参观走廊4长度方向依次设有相邻的理化室51、流式细胞室52、微生物培养室53、第七缓冲室54、样本接收室510、第八缓冲室59、样本接收室58、清洁室56和洗消室55;所述样本接收室58远离所述第一参观走廊4一侧设有与其相邻的冷冻室57;所述第七缓冲室54处于所述微生物培养室53拐角处且与所述第一参观走廊4和所述样本接收室510均相邻;所述第八缓冲室59处于所述样本接收室510拐角处且与所述第一参观走廊4和所述样本接收室58均相邻。Further, please refer to FIG. 7 , the quality control area 5 is provided with adjacent physical and chemical chambers 51, flow cytometry chambers 52, microorganism culture chambers 53, and seventh buffers in sequence along the length of the first visiting corridor 4. The chamber 54, the sample receiving chamber 510, the eighth buffer chamber 59, the sample receiving chamber 58, the cleaning chamber 56 and the decontamination chamber 55; the sample receiving chamber 58 is provided with a side adjacent to the sample receiving chamber 58 away from the first visiting corridor 4. Freezing chamber 57; the seventh buffer chamber 54 is located at the corner of the microorganism culture chamber 53 and adjacent to the first visiting corridor 4 and the sample receiving chamber 510; the eighth buffer chamber 59 is located in the The sample receiving room 510 is at the corner and adjacent to both the first visiting corridor 4 and the sample receiving room 58 .

使用时,从楼梯进入到多功能展示厅,经过多功能展示厅后进入第一参观走廊,通过第一参观走廊依次进入质量控制区中的各个实验室。When in use, enter the multi-functional exhibition hall from the stairs, enter the first visiting corridor after passing through the multi-functional exhibition hall, and enter each laboratory in the quality control area in turn through the first visiting corridor.

实施例8Example 8

进一步的,请参阅图8所示,所述货物区3内部从所述第一洁净走廊74到所述第二洁净走廊76的方向依次设有与所述多功能展示厅1相邻的第一物料入口31、第二洁净物料库32、第三洁净物料库33和第二物料入口34;所述第一物料入口31与所述第一洁净走廊74和所述第二洁净物料库32相邻处均设有双扉传递窗;所述第二物料入口32与所述第二洁净走廊76和所述第三洁净物料库33相邻处均设有双扉传递窗。Further, as shown in FIG. 8 , the interior of the cargo area 3 is sequentially provided with a first clean corridor adjacent to the multifunctional exhibition hall 1 in the direction from the first clean corridor 74 to the second clean corridor 76 . Material inlet 31 , second clean material warehouse 32 , third clean material warehouse 33 and second material inlet 34 ; the first material inlet 31 is adjacent to the first clean corridor 74 and the second clean material warehouse 32 There are double-leaf transfer windows at all places; the second material inlet 32 and the second clean corridor 76 and the third clean material storehouse 33 are provided with double-leaf transfer windows adjacent to each other.

双扉传递窗作用于货物的传递。The double-leaf transfer window acts on the transfer of goods.

实施例9Example 9

进一步的,所述第一洁净走廊74与所述第二洁净走廊76相邻处设有紧急疏散逃离窗;所述第一洁净走廊74与所述第二参观走廊2相邻处设有紧急疏散逃离窗;所述第二洁净走廊74与所述第一参观走廊4相邻处设有紧急疏散逃离窗;所述第三洁净走廊75与所述第三参观走廊6相邻且相邻处设有紧急疏散观察窗;所述第四洁净走廊77与所述第三参观走廊6相邻且相邻处设有紧急疏散观察窗。Further, an emergency evacuation escape window is provided adjacent to the first clean corridor 74 and the second clean corridor 76; an emergency evacuation window is provided adjacent to the first clean corridor 74 and the second visiting corridor 2 Escape window; the second clean corridor 74 is provided with an emergency evacuation escape window adjacent to the first visiting corridor 4 ; the third clean corridor 75 is adjacent to the third visiting corridor 6 and adjacent to the There are emergency evacuation observation windows; the fourth clean corridor 77 is adjacent to the third visiting corridor 6 and an emergency evacuation observation window is provided adjacent thereto.

紧急疏散逃离窗作用于在发生紧急情况时能够及时避险逃生。The emergency evacuation escape window is used to escape in time in the event of an emergency.

进一步的,所述多功能展示厅1远离所述货物区3一侧的两端设有进出楼梯。Further, both ends of the multi-functional exhibition hall 1 on the side away from the cargo area 3 are provided with access stairs.

以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化;凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes; all within the spirit and principles of the present invention, Any modification, equivalent replacement, improvement, etc. made should be included within the protection scope of the present invention.

Claims (8)

1. A multi-cell preparation laboratory comprising a core preparation area (7), characterized in that: a quality control area (5), a special sample preparation area (8), a third visiting corridor (6) and a goods area (3) are respectively arranged on the periphery of the core preparation area (7); a first visiting corridor (4) is arranged between the core preparation area (7) and the quality control area (5), and a second visiting corridor (2) is arranged between the core preparation area (7) and the special sample preparation area (8); the third visit corridor (6) is respectively communicated with the first visit corridor (4) and the second visit corridor (2); -the cargo area (3) is located between the first and second corridor of visits (4, 2); a multifunctional exhibition hall (1) is arranged on one side of the cargo area (3) opposite to the core preparation area (7); the multifunctional exhibition hall (1) is adjacent to the special sample preparation area (8), the second visit corridor (2), the first visit corridor (4) and the quality control area (5); stairs are arranged on two opposite sides of the multifunctional display hall (1);
the core preparation area (7) comprises a first preparation area (71), a second preparation area (72) and a third preparation area (73) adjacent to the third corridor of observation (6) on one side; a first clean corridor (74) is arranged on the other side, opposite to the first preparation area (71); the opposite sides of the second preparation area (72) and the third preparation area (73) are provided with a second clean corridor (76); a third clean corridor (75) communicated with the first clean corridor (74) is arranged between the first preparation area (71) and the second preparation area (72), and a fourth clean corridor (77) communicated with the second clean corridor (76) is arranged between the second preparation area (72) and the third preparation area (73); the first clean corridor (74) is adjacent to the second clean corridor (76);
a first waste outlet (726), a first gas cylinder room (725), a program-controlled cooling room (724), a stem cell culture and preparation issuing room (728), a stem cell culture room (723), an umbilical cord stem cell preparation room (722) and an umbilical cord blood cell preparation room (721) which are adjacent to the third clean corridor (75) are sequentially arranged in the second preparation area (72) from the third visit corridor (6) to the second clean corridor (76); a second waste outlet (7210) is arranged on the side, away from the third clean corridor (75), of the first waste outlet (726); a second gas cylinder room (729) is arranged on one side, away from the third clean corridor (75), of the first gas cylinder room (725); two sides of the second gas cylinder chamber (729) are respectively adjacent to the second waste outlet (7210) and the program-controlled cooling chamber (724); a stem cell centrifugal chamber (727) adjacent to the stem cell culture chamber (723) is arranged on one side, away from the third clean corridor (75); the two sides of the stem cell centrifugal chamber (727) are respectively adjacent to the stem cell culture and preparation dispensing chamber (728) and the umbilical cord stem cell preparation chamber (722); a short corridor is provided between the first waste outlet (726) and the first cylinder room (725), the other side of the short corridor being adjacent to the second waste outlet (7210) and the second cylinder room (729).
2. The multi-cell preparation laboratory according to claim 1, wherein a first immune cell culture chamber (711), a third immune cell preparation chamber (712), a second immune cell culture chamber (713), a fourth immune cell preparation chamber (714), a first dressing chamber (715), a second dressing chamber (718) and an immune cell sample receiving chamber (716) are sequentially disposed inside the first preparation area (71) from the third corridor (6) to the first clean corridor (74) adjacent to the second corridor (2); a first immune cell centrifugal chamber (7112) adjacent to the third immune cell preparation chamber (712) is arranged on one side of the first immune cell culture chamber (711) far away from the second observation corridor (2); a second immune cell centrifugal chamber (7111) which is adjacent to the third immune cell preparation chamber (712) and the fourth immune cell preparation chamber (714) is arranged on one side, away from the second observation corridor (2), of the second immune cell culture chamber (713); a first buffer area (7110) and a second buffer area (719) are sequentially arranged on one side, away from the second visiting corridor (2), of the first dressing room (715), the first buffer area (7110) is adjacent to the fourth immune cell preparation room (714), and the second buffer area (719) is adjacent to the second dressing room (718); the side of the immune cell sample receiving chamber (716) far away from the second visit corridor (2) is provided with a first retreat chamber (717) adjacent to the second dressing chamber (718) and the first clean corridor (74).
3. The multi-cell preparation laboratory according to claim 1, wherein a placental blood cell preparation chamber (731), a centrifugal chamber (732), an adult adipose stem cell preparation chamber (733), a culture chamber (734), a third buffer region (7310), a fourth buffer region (739), a third dressing chamber (737), a second retreat chamber (738) are sequentially disposed inside the third preparation region (73) from the third observation corridor (6) to the second clean corridor (76) adjacent to the fourth clean corridor (77); a fourth dressing room (735) adjacent to the third buffer area (7310) and the fourth buffer area (739) is arranged on one side of the third buffer area (7310) far away from the fourth clean corridor (77), and two sides of the fourth dressing room (735) are respectively adjacent to the culture room (734) and the third dressing room (737); a stem cell sample receiving chamber (736) adjacent to the second retreating chamber (738) is arranged on one side of the second retreating chamber (738) far away from the fourth clean corridor (77); the stem cell sample receiving chamber (736) is flanked by the third dressing chamber (737) and a second clean corridor (76), respectively.
4. The multi-cell preparation laboratory according to claim 1, wherein said special sample preparation area (8) is provided with a working cell bank (81), a fifth dressing room (88), a sixth dressing room (811), a fifth clean corridor (83), a positive centrifugal room (812), a positive preparation culture room (813), a third waste outlet (817), a first transition room (816), a second transition room (815), a total sample receiving room (85) and an outer sample collecting room (814) which are adjacent to each other along the length direction of said second observation corridor (2); a third retreating and changing chamber (82) adjacent to the fifth changing room (88) is arranged on one side of the fifth changing room (88) far away from the second visiting corridor (2), and the third retreating and changing chamber (82) is adjacent to the working cell bank (81); a fifth buffer chamber (89) and a sixth buffer chamber (810) which are adjacent to the sixth dressing chamber (811) are sequentially arranged on one side, away from the second visiting corridor (2), of the sixth dressing chamber; a first clean material storage (84) adjacent to both the first transition chamber (816) and the second transition chamber (815) is arranged on one side of the first transition chamber (816) far away from the second observation corridor (2); a waste temporary storage chamber (86) adjacent to the sample collection outer chamber (814) is sequentially arranged on one side of the sample collection outer chamber, which is far away from the second visiting corridor (2); a fifth clean corridor (83) is arranged between the third returning and replacing chamber (82) and the first clean material storage (84), and the fifth clean corridor (83) is adjacent to the fifth buffer chamber (89), the sixth buffer chamber (810), the positive centrifugal chamber (812) and the positive preparation culture chamber (813); said fifth clean corridor (83) is provided with two branching corridors, one of which is located between said sixth changing room (811) and a positive centrifugal chamber (812); another said branched corridor being between said positive preparation culture chamber (813) and said first clean material store (84) and adjacent to said third waste outlet (817); a double-door transfer window is arranged at the position of the third waste outlet (817) adjacent to the positive preparation culture chamber (813).
5. A multi-cell preparation laboratory according to claim 1, wherein said quality control area (5) is provided with a physicochemical chamber (51), a flow cell chamber (52), a microorganism culture chamber (53), a seventh buffer chamber (54), a first sample receiving chamber, an eighth buffer chamber (59), a second sample receiving chamber, a clean chamber (56) and a wash and sterilize chamber (55) which are adjacent in sequence along the length of said first observation corridor (4); the second sample receiving chamber is provided with a freezing chamber (57) adjacent to the second sample receiving chamber on the side far away from the first access corridor (4); said seventh buffer chamber (54) being at a corner of said microbiological culture chamber (53) and adjacent to both said first observation corridor (4) and said first sample receiving chamber; the eighth buffer chamber (59) is at a corner of the first sample-receiving chamber and adjacent to both the first viewing corridor (4) and the second sample-receiving chamber.
6. A multi-cell preparation laboratory according to claim 1, characterized in that a first material inlet (31), a second clean material store (32), a third clean material store (33) and a second material inlet (34) are provided inside the cargo area (3) in sequence from the first clean corridor (74) to the second clean corridor (76) adjacent to the multi-functional showroom (1); double-leaf delivery windows are arranged at the positions of the first material inlet (31), which are adjacent to the first clean corridor (74) and the second clean material warehouse (32); and double-leaf transfer windows are arranged at the positions of the second material inlet (34), which are adjacent to the second clean corridor (76) and the third clean material storage (33).
7. A multi-cell preparation laboratory according to claim 1, wherein said first clean corridor (74) is provided with an emergency evacuation escape window adjacent to said second clean corridor (76); an emergency evacuation escape window is arranged at the position, adjacent to the second visit corridor (2), of the first clean corridor (74); an emergency evacuation escape window is arranged at the position, adjacent to the first visit corridor (4), of the second clean corridor (76); the third clean corridor (75) is adjacent to the third visiting corridor (6), and an emergency evacuation observation window is arranged at the adjacent position; and the fourth clean corridor (77) is adjacent to the third visiting corridor (6) and an emergency evacuation observation window is arranged at the adjacent position.
8. A multi-cell preparation laboratory according to claim 7, wherein said multifunctional showroom (1) is provided with access stairs at both ends of the side away from said cargo area (3).
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006094754A (en) * 2004-09-29 2006-04-13 Sanyo Electric Co Ltd Cell culture facility
CN101619285A (en) * 2009-07-15 2010-01-06 闫铭杰 Production platform system of human body fluid and tissue cells
CN101974484A (en) * 2010-11-03 2011-02-16 江苏省北科生物科技有限公司 Method for preparing human umbilical cord mesenchymal stem cells
CN104204193A (en) * 2012-02-13 2014-12-10 加米达细胞有限公司 Culturing of mesenchymal stem cells
CN104847139A (en) * 2015-04-13 2015-08-19 上海安集协康生物技术有限公司 Clean cell production workshop
EP3070159A1 (en) * 2013-11-12 2016-09-21 Tokyo Electron Limited Method and facility for culturing pluripotent stem cells
CN206368171U (en) * 2016-12-28 2017-08-01 上海源培生物科技股份有限公司 A kind of cell culture room

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006094754A (en) * 2004-09-29 2006-04-13 Sanyo Electric Co Ltd Cell culture facility
CN101619285A (en) * 2009-07-15 2010-01-06 闫铭杰 Production platform system of human body fluid and tissue cells
CN101974484A (en) * 2010-11-03 2011-02-16 江苏省北科生物科技有限公司 Method for preparing human umbilical cord mesenchymal stem cells
CN104204193A (en) * 2012-02-13 2014-12-10 加米达细胞有限公司 Culturing of mesenchymal stem cells
EP3070159A1 (en) * 2013-11-12 2016-09-21 Tokyo Electron Limited Method and facility for culturing pluripotent stem cells
CN104847139A (en) * 2015-04-13 2015-08-19 上海安集协康生物技术有限公司 Clean cell production workshop
CN206368171U (en) * 2016-12-28 2017-08-01 上海源培生物科技股份有限公司 A kind of cell culture room

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act;Manabu Mizutani等;《Regenerative Therapy》;20160716;第5卷;第26页第2.1节,图1 *
Manabu Mizutani等.Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act.《Regenerative Therapy》.2016,第5卷第26页第2.1节,图1. *
The Minnesota Molecular and Cellular Therapeutics Facility:;David H McKenna等;《Transfusion Medicine Reviews》;20050707;第19卷(第3期);全文 *
临床细胞治疗技术平台设计探讨;杨润宇;《化工与医药工程》;20151015;第36卷(第5期);第33页第2.2.1节,第34页图3 *

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