CN108187132A - A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof - Google Patents
A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof Download PDFInfo
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- CN108187132A CN108187132A CN201810012624.3A CN201810012624A CN108187132A CN 108187132 A CN108187132 A CN 108187132A CN 201810012624 A CN201810012624 A CN 201810012624A CN 108187132 A CN108187132 A CN 108187132A
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- povidone iodine
- iodine
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 229920000153 Povidone-iodine Polymers 0.000 title claims abstract description 97
- 229960001621 povidone-iodine Drugs 0.000 title claims abstract description 97
- 239000000017 hydrogel Substances 0.000 title claims abstract description 68
- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 78
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 57
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229920001661 Chitosan Polymers 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000011187 glycerol Nutrition 0.000 claims abstract description 19
- 229960000502 poloxamer Drugs 0.000 claims abstract description 19
- 229920001983 poloxamer Polymers 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 7
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 37
- 239000011630 iodine Substances 0.000 claims description 34
- 229910052740 iodine Inorganic materials 0.000 claims description 34
- 230000001954 sterilising effect Effects 0.000 claims description 22
- 238000004659 sterilization and disinfection Methods 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 21
- 230000000844 anti-bacterial effect Effects 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000012456 homogeneous solution Substances 0.000 claims description 7
- 230000005855 radiation Effects 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 3
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 22
- 208000027418 Wounds and injury Diseases 0.000 abstract description 22
- 230000029663 wound healing Effects 0.000 abstract description 13
- 231100000241 scar Toxicity 0.000 abstract description 10
- 230000000845 anti-microbial effect Effects 0.000 abstract description 7
- 230000000857 drug effect Effects 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 230000036560 skin regeneration Effects 0.000 abstract description 3
- 230000007812 deficiency Effects 0.000 abstract description 2
- 230000006641 stabilisation Effects 0.000 abstract description 2
- 238000011105 stabilization Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 22
- 230000000694 effects Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 11
- 239000011260 aqueous acid Substances 0.000 description 6
- 230000006196 deacetylation Effects 0.000 description 6
- 238000003381 deacetylation reaction Methods 0.000 description 6
- 239000000052 vinegar Substances 0.000 description 6
- 235000021419 vinegar Nutrition 0.000 description 6
- 230000001408 fungistatic effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000004964 aerogel Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000002632 myometrial effect Effects 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of povidone iodine hydrogel antiseptic dressings and preparation method thereof, belong to field of medicaments.In view of the deficiencies of the prior art, the object of the invention provides a kind of povidone iodine hydrogel antiseptic dressing, is made by the raw material of following weight parts：0.25~1 part of chitosan, 0.5~3 part of povidone iodine, 0.5~2 part of propylene glycol, 2~6 parts of glycerine, 10~20 parts of poloxamer, 2~4 parts of acetic acid, 100~120 parts of purified water.The antiseptic dressing can make wound be in an environment moistened and alleviate the drug effect release of povidone iodine, extend the duration of drug effect, it is and good antimicrobial effect, stabilization, applied widely, also there is good therapeutic effect to wound healing, promote skin regeneration, reduce scar and formed.
Description
Technical field
The present invention relates to a kind of povidone iodine hydrogel antiseptic dressings and preparation method thereof, belong to field of medicaments.
Background technology
Povidon iodine (PVP-I2 is commonly called as povidone iodine, Povidone-Iodine Solution) is a kind of external sterilizing preservative, be by
A kind of amorphous compound to be formed is complexed with iodine in high-molecular compound polyvinylpyrrolidone.Its solution contact sterilizing face or wound
Depolymerization releases iodine behind the affected parts such as face, so as to have the function that antibacterial anti-inflammatory.Povidone iodine has wide spectrum, efficient sterilization spy
Point, it has also become widely applied efficient sterilization disinfectant.
The sterilisation quality of povidone iodine depends on the stability of available iodine content, although overcoming iodine dissolving to a certain extent
The shortcomings of spending low, unstable, easy generation allergic reaction, but still there is larger skin irritation, slow release effect is also poor.In recent years
Come, chitosan starts to attract people's attention in the application of technical field of biological material, and chitosan is a kind of excellent height of biological property
Molecular compound, after adsorbing iodine, the thermal stability of iodine greatly improves.Chitosan iodine is a kind of efficient, wide spectrum, nontoxic macromolecule
Medical disinfecting sterilization material.It gradually can release iodine and play antibacterial action, mechanism of action be make bacterium protein denaturation,
Death, it is effective and small to tissue irritation to bacterium, fungi, virus.
The correct processing of surgical wound is the key that one of surgical operation therapy success or failure, and the good healing of the surface of a wound is wound
The premise of body function rehabilitation afterwards, therefore, the research for accelerating wound healing are extremely important, wherein being to grind to the development of Wound dressing
One of hot spot studied carefully.To wound healing research shows that, using the purpose of dressing, not just flap coverage, dressing should also have
Promote the effect of wound healing.
People have found that speed of wound healing ratio is exposed to air drying wound under closed moist environment in zoopery
Face is more fast again.The aerogel dressing based on this thought is widely developed as a result,.But existing method and product are being controlled
It is often unsatisfactory in therapeutic effect.Still have in view of the above problems, preparing a kind of povidone-iodine antibacterial aerogel dressing drug
There is important actual application value.
Invention content
In view of the deficiencies of the prior art, the object of the invention provides a kind of povidone iodine hydrogel antiseptic dressing, which applies
Material can make wound be in an environment moistened and alleviate the drug effect release of povidone iodine, extend the duration of drug effect,
And it is good antimicrobial effect, stabilization, applied widely, also there is good therapeutic effect to wound healing, promote skin regeneration, reduce
Scar is formed.
The purpose of the present invention is achieved through the following technical solutions：
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：0.25~1 part of chitosan, 0.5~3 part of povidone iodine, 0.5~2 part of propylene glycol, 2~6 parts of glycerine, poloxamer
10~20 parts, 2~4 parts of acetic acid, 100~120 parts of purified water.
The deacetylation of the chitosan is more than 90%, and the molecular weight ranges of the chitosan are 4000~10000.
The povidone iodine is the complex compound of iodine and polyvinylpyrrolidone, and the effective content of iodine is 9~12%.
Preferably, the povidone iodine hydrogel antiseptic dressing is made by the raw material of following weight parts：Chitosan 0.5~
0.8 part, 1~2.5 part of povidone iodine, 1~1.5 part of propylene glycol, 3~5 parts of glycerine, 13~17 parts of poloxamer, acetic acid 2.5~
3.5 parts, 105~115 parts of purified water.
It is furthermore preferred that the povidone iodine hydrogel antiseptic dressing is made by the raw material of following weight parts：Chitosan 0.6
Part, 1.8 parts of povidone iodine, 1.2 parts of propylene glycol, 4 parts of glycerine, 15 parts of poloxamer, 3 parts of acetic acid, 110 parts of purified water.
It is a further object of the present invention to provide a kind of preparation method of povidone iodine hydrogel antiseptic dressing, including following step
Suddenly：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It is stood at 2~10 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 2~12h after sterilization treatment to get poly- dimension
Ketone iodine anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Application of the above-mentioned povidone iodine hydrogel antiseptic dressing in antibacterial medicines are prepared is also claimed in the present invention.
Povidone iodine hydrogel antiseptic dressing of the present invention has following technical advantage：
1) hydrogel antimicrobial dressing produced by the present invention combines the advantage of both chitosan, povidone iodine, bio-compatible
Property high, the antibiotic property both enhanced, reduce the biostimulation of povidone iodine, Medical dressing, antibacterial can be used as
Membrane material etc. has wide practical use in fields such as food, medicine, textile industries.
2) hydrogel antimicrobial dressing of the invention, Zhi Xu local applications just can reach therapeutic purposes, avoid systemic administration and
Unnecessary side effect is brought, is that there is superior sterilization, repair difunctional antiseptic.
3) hydrogel antimicrobial dressing produced by the present invention can slow release free-iodine, maintain persistently kill bacterium, fungi, disease
The effect of poison, effectively prevent the infection of wound.
4) hydrogel antimicrobial dressing is in direct contact with the surface of a wound, plays the role of antibacterial, can keep the permanent antibacterial of the surface of a wound, also
The absorbable extra sepage of the surface of a wound and the moist environment for keeping wound, make wound be chronically at stable moist state, are conducive to promote
Into skin regeneration, accelerating wound healing, reduction forms scar.
Specific embodiment
With reference to embodiment, the claim of the present invention is described in further detail, but do not formed pair
Any restrictions of the present invention.
Embodiment 1
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：0.25 part of chitosan, 0.5 part of povidone iodine, 0.5 part of propylene glycol, 2 parts of glycerine, 10 parts of poloxamer, 2 parts of acetic acid,
100 parts of purified water.The deacetylation of the chitosan is 91%, and the molecular weight of the chitosan is 4000.The povidone iodine
It is the complex compound of iodine and polyvinylpyrrolidone, the effective content of iodine is 9%.
A kind of preparation method of povidone iodine hydrogel antiseptic dressing, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It is stood at 2 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 2h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Embodiment 2
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：1 part of chitosan, 3 parts of povidone iodine, 2 parts of propylene glycol, 6 parts of glycerine, 20 parts of poloxamer, 4 parts of acetic acid, purified water
120 parts.The deacetylation of the chitosan is 99%, and the molecular weight of the chitosan is 10000.The povidone iodine be iodine and
The complex compound of polyvinylpyrrolidone, the effective content of iodine is 12%.
A kind of preparation method of povidone iodine hydrogel antiseptic dressing, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It is stood at 10 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 12h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Embodiment 3
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：0.5 part of chitosan, 1 part of povidone iodine, 1 part of propylene glycol, 3 parts of glycerine, 13 parts of poloxamer, 2.5 parts of acetic acid are pure
Change 105 parts of water.The deacetylation of the chitosan is 93%, and the molecular weight of the chitosan is 6000.The povidone iodine is
The complex compound of iodine and polyvinylpyrrolidone, the effective content of iodine is 10%.
A kind of preparation method of povidone iodine hydrogel antiseptic dressing, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It stands at 5 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 5h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Embodiment 4
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：0.8 part of chitosan, 2.5 parts of povidone iodine, 1.5 parts of propylene glycol, 5 parts of glycerine, 17 parts of poloxamer, acetic acid 3.5
Part, 115 parts of purified water.The deacetylation of the chitosan is 97%, and the molecular weight of the chitosan is 8000.The povidone
Iodine is the complex compound of iodine and polyvinylpyrrolidone, and the effective content of iodine is 11%.
A kind of preparation method of povidone iodine hydrogel antiseptic dressing, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It is stood at 8 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 10h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Embodiment 5
A kind of povidone iodine hydrogel antiseptic dressing, the povidone iodine hydrogel antiseptic dressing is by following weight parts
Raw material is made：0.6 part of chitosan, 1.8 parts of povidone iodine, 1.2 parts of propylene glycol, 4 parts of glycerine, 15 parts of poloxamer, 3 parts of acetic acid,
110 parts of purified water.The deacetylation of the chitosan is 95%, and the molecular weight of the chitosan is 7000.The povidone iodine
It is the complex compound of iodine and polyvinylpyrrolidone, the effective content of iodine is 12%.
A kind of preparation method of povidone iodine hydrogel antiseptic dressing, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, stirs evenly while stirring
It is stood at 6 DEG C afterwards, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the vinegar for the surplus that step 1) prepares
In aqueous acid, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 8h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
The preparation method of the povidone iodine hydrogel antiseptic dressing, in step 4), sterilization treatment mode is gone out for radiation
Bacterium.
Test 1：The measure of amount of iodine
Povidone iodine hydrogel antiseptic dressing made from Examples 1 to 5 is applied to the surface of a wound, respectively at 8h, 16h, for 24 hours after
It takes off, measures remaining amount of iodine.The assay method of amount of iodine：Povidone iodine hydrogel antibacterial is added in 250mL iodine flasks to apply
Material adds in distilled water 50mL, seals and shake it is promoted fully to dissolve, molten with the 0.1molL-1 sodium thiosulfate demarcated
Drop is determined to completely disappear up to yellow, consumption volume is recorded, and calculate (0.1molL-1 used to available iodine content
Hypo solution 1mL is suitable with 12.69mg iodine), the results are shown in Table 1.
The remaining amount of iodine of table 1
| Group | 8h amount of iodine (g) | 16h amount of iodine (g) | Amount of iodine (g) for 24 hours |
| Embodiment 1 | 0.045 | 0.043 | 0.041 |
| Embodiment 2 | 0.039 | 0.037 | 0.034 |
| Embodiment 3 | 0.050 | 0.047 | 0.045 |
| Embodiment 4 | 0.048 | 0.045 | 0.042 |
| Embodiment 5 | 0.056 | 0.052 | 0.050 |
As seen from the above table, after for 24 hours, the amount of iodine of povidone iodine hydrogel antiseptic dressing produced by the present invention is not aobvious
It writes and declines, can continue to play sterilization drug effect.
Test 2：Fungistatic effect
According to document, staphylococcus aureus, Candida albicans, Escherichia coli are selected as experimental bacteria.According to GB2738-
Experimental method described in 2012 does bacteriostatic experiment to povidone iodine hydrogel antiseptic dressing made from embodiment 1-5.It is antibacterial：Using
Chemically or physically method inhibits or interferes the process of bacterial growth breeding and activity.
2 fungistatic effect (the time of table：2.5h)
The experimental results showed that the fungistatic effect of embodiment 5 is best, and povidone iodine hydrogel antibacterial prepared by the present invention
Dressing respectively reaches 93%, 89%, more than 91% to the inhibiting rate of staphylococcus aureus, Candida albicans, Escherichia coli, suppression
Bacterium effect is good, and fungistatic effect is lasting.
Test 3：Hydrogel antimicrobial dressing sample skin irritation index (PII) measures
Closed sensitization test (STT) method is measured as defined in GB/T16886.10-2000, and testing result is referring to table 3.
Table 3
| Test event | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Skin irritation index | 0 | 0 | 0 | 0 | 0 |
| Sensitization of skin | Nothing | Nothing | Nothing | Nothing | Nothing |
From table 3 it can be seen that povidone iodine hydrogel antiseptic dressing produced by the present invention is caused without skin irritatin and skin
Quick reaction.
Test 4：Biocompatibility experiment
Povidone iodine hydrogel antiseptic dressing made from embodiment 1-5 is injected separately into white rabbit body, timing is observed, continuously
7 days weight, feed, body temperature, activity are without exception.It is good to illustrate that cationic Medical Living Creature Gum antiseptic dressing produced by the present invention has
Biocompatibility.
Test 5：Hemostasis effect
Test sample：Povidone iodine hydrogel antiseptic dressing made from embodiment 1-5.
Thrombotest：The teat glass of a diameter of 8mm is taken, often pipe is separately added into the above-mentioned antiseptic dressings of 0.05mg, 0.95ml
Deionized water adds calcium chloride solution 1ml；It shakes up after in each pipe while adding in anti-freezing blood plasma 1ml, jog, mixing are put into
It is observed in 37 degrees Celsius of water-bath, the timing since being added in anti-freezing blood plasma, until mixed liquor solidifies, timing stops, as a result
It is shown in Table 4.
Table 4
| Group | Normal coagulation | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Clotting time (min) | 9.34 | 4.82 | 5.21 | 4.02 | 4.36 | 3.62 |
From table 4, it can be seen that povidone iodine hydrogel antiseptic dressing produced by the present invention shows blood coagulation resisting function, and anti-
Coagulating effectiveness is preferable.
Test 6：Promote wound healing effect
Experimental animal uses SD male rats, every weight 250-270g, every group of 20 animals.In rat back vertebra one
Side cuts off white hair, is 1cm*1cm with scalpel incised wound face size under narcosis, the edge of a knife of depth 0.2cm.Respectively at wound
Afterwards 2,5,8,12,16d observations.The povidone iodine hydrogel antiseptic dressing obtained by embodiment 1-5 is coated on wound respectively, often
Each painting is primary sooner or later for it, is covered with paraffin degreasing gauze, then bandage, physiological saline is given through abdominal cavity after wound.In respectively taking
Sample time point calculates Wound healing rate.The area of the surface of a wound, calculating Wound healing rate=(control are measured using standard transparent grid film
Treat product behind the product-treatment of front)/treatment front product * 100%.
5 wound healing situation (%) of table
| Sample number of days | 2d | 5d | 8d | 12d | 16d |
| Embodiment 1 | 12.4±1.2 | 35.1±1.8 | 76.2±1.2 | 93.2±1.2 | 97.5±1.1 |
| Embodiment 2 | 11.8±0.8 | 34.5±1.4 | 75.3±1.6 | 91.4±1.5 | 96.8±1.6 |
| Embodiment 3 | 13.1±1.5 | 37.2±1.6 | 78.3±1.5 | 94.1±1.3 | 99.3±1.3 |
| Embodiment 4 | 13.5±1.4 | 36.5±1.1 | 78.9±1.7 | 93.8±1.6 | 98.5±1.5 |
| Embodiment 5 | 14.9±1.6 | 39.6±1.5 | 80.1±0.9 | 95.1±1.4 | 99.6±1.2 |
As shown in Table 5, after povidone iodine hydrogel antiseptic dressing of the invention application, the surface of a wound of each sample point averagely heals
Preferably, the surface of a wound healing rate that is averaged is more than 96% and at 16 days, illustrates that the povidone iodine hydrogel antiseptic dressing of the present invention promotes
Wound healing effect is very good.
Test 7：Reduce scar curative effect index
The patient of fresh surgical notch caused by surgical operation is selected, totally 100, wherein man 50, female 50 is average
40.5 years old age, every 20 people are divided into one group, every group average age relatively on no significant difference, be comparable, incision length
14-20cm, average 15.90cm.Patient is randomly divided into 5 groups of carry out clinical observations.Every group uses povidone iodine hydrogel antibacterial
Povidone iodine hydrogel antiseptic dressing obtained by embodiment 1-5 after myometrial suture, is coated on incision, coating by dressing respectively
Width is each 4~5mm in operative incision both sides.After this product is applied to operative incision, you can automatically form protective film, 3 times a day.It changes
During medicine, physiological saline or Iodophor are dipped with cotton balls, is wiped repeatedly 3-5 times, the surface of a wound is removed totally substantially, then by smearing this product.Hand
After art myometrial suture, postoperative 2nd day or dressing in the 3rd day it is primary.
Diagnose scar standard
(1) it is good：Refer to flat scar, trend is parallel with skin slope line, and color is identical with normal skin tone；
(2) it is slight：Scar slightly emblem is swelled, and color is a little deeper than normal skin tone；
(3) it is apparent：Refer to the exhausted trace of protuberance, it is darker, and can itch, pain, but the degree swelled does not exceed wound
Range, and a period of time after can flatten.
Table 6
Since cicatrization is according to the difference of individual physique and the notch surface of a wound, forms scar and also have nothing in common with each other；Therefore, to subtracting
Few scar curative effect can not be evaluated conclusively, and being only capable of can by the povidone iodine hydrogel antiseptic dressing of the description of test present invention
Scar is formed to reduce.
Claims (8)
1. a kind of povidone iodine hydrogel antiseptic dressing, which is characterized in that it is made by the raw material of following weight parts：Chitosan
0.25~1 part, 0.5~3 part of povidone iodine, 0.5~2 part of propylene glycol, 2~6 parts of glycerine, 10~20 parts of poloxamer, acetic acid 2~
4 parts, 100~120 parts of purified water.
2. povidone iodine hydrogel antiseptic dressing according to claim 1, which is characterized in that it is by following weight parts
Raw material is made：0.5~0.8 part of chitosan, 1~2.5 part of povidone iodine, 1~1.5 part of propylene glycol, 3~5 parts of glycerine, poloxamer
13~17 parts, 2.5~3.5 parts of acetic acid, 105~115 parts of purified water.
3. povidone iodine hydrogel antiseptic dressing according to claim 1, which is characterized in that it is by following weight parts
Raw material is made：0.6 part of chitosan, 1.8 parts of povidone iodine, 1.2 parts of propylene glycol, 4 parts of glycerine, 15 parts of poloxamer, 3 parts of acetic acid,
110 parts of purified water.
4. povidone iodine hydrogel antiseptic dressing according to claim 1, which is characterized in that the chitosan it is deacetylated
Degree is more than 90%, and the molecular weight ranges of the chitosan are 4000~10000.
5. povidone iodine hydrogel antiseptic dressing according to claim 1, which is characterized in that the povidone iodine be iodine and
The complex compound of polyvinylpyrrolidone, the effective content of iodine is 9~12%.
6. a kind of preparation method according to claim 1-3 any one of them povidone iodine hydrogel antiseptic dressings, feature
It is, includes the following steps：
1) acetic acid of formula ratio is added in the purified water of formula ratio, stirring is to being completely dissolved；
2) aqueous acetic acid that appropriate step 1) is taken to prepare adds in the poloxamer of formula ratio, 2 after stirring evenly while stirring
It is stood at~10 DEG C, it is made fully to be swollen to form homogeneous solution a；
3) the another chitosan for taking formula ratio, povidone iodine, propylene glycol and glycerine are dissolved in the acetic acid water for the surplus that step 1) prepares
In solution, it is evenly stirred until and is completely dissolved to obtain solution b；
4) solution a and solution b are mixed evenly, and at normal temperatures be aged 2~12h after sterilization treatment to get povidone iodine
Anti-bacterial hydrogel.
7. the preparation method of povidone iodine hydrogel antiseptic dressing according to claim 6, which is characterized in that step 4)
In, sterilization treatment mode is radiation sterilization.
8. the antiseptic dressing that a kind of method according to claim 6 is prepared is used to prepare the purposes of antibacterial medicines.
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| CN114209646A (en) * | 2021-12-29 | 2022-03-22 | 艾威药业(珠海)有限公司 | Povidone-iodine temperature-sensitive gel preparation |
| CN114209646B (en) * | 2021-12-29 | 2024-01-19 | 艾威药业(珠海)有限公司 | Povidone iodine temperature-sensitive gel preparation |
| CN114618012A (en) * | 2022-04-01 | 2022-06-14 | 上海医妃医药科技有限公司 | Liquid dressing with skin care effect |
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