CN108186966A

CN108186966A - A kind of composition for preventing or improving senile dementia and its application

Info

Publication number: CN108186966A
Application number: CN201810252992.5A
Authority: CN
Inventors: 叶学敏
Original assignee: Hengqin En Health Biotechnology Co Ltd
Current assignee: Hengqin En Health Biotechnology Co Ltd
Priority date: 2018-03-26
Filing date: 2018-03-26
Publication date: 2018-06-22

Abstract

The invention discloses a kind of composition for preventing or improving senile dementia and its applications, belong to Halth-care composition technical field.The composition includes following raw material by weight：25 parts of ginseng pulverate, 25 parts of Radix Notoginseng powder, 2 20 parts of hawthorn powder, 15 parts of wolfberry fruit powder, 15 parts of yam flour, 15 parts of Fructus Schisandrae Chinensis powder, 15 parts of Radix Polygalae powder, 0.2 4.0 parts of sorosis powder, 0.05 1.1 parts of gingko powder, 0.1 2.5 parts of kudzu-vine root powder, 0.1 2.5 parts of rhizoma alismatis powder, 0.1 2.5 parts of walnut powder, 0.2 1.6 parts of rhodiola root powder, 13 parts of astragalus membranaceus powder, 13 parts of raspberry powder, 13 parts of fructus alpiniae oxyphyllae powder, 5 15 parts of red date powder.The composition compatibility is scientific and reasonable, effectively prevent infringement of the free radical to human body, has prevention and improvement result well to senile dementia, and preparation method is simple, and production cost is low, carries convenient, sweet and sour taste.

Description

A kind of composition for preventing or improving senile dementia and its application

Technical field

The present invention relates to Halth-care composition technical fields, and in particular to a kind of combination prevented or improve senile dementia Object and its application.

Background technology

Senile dementia or senile Alzheimer disease (Alzheimer ' s disease, AD) are worldwide old age The common disease of people accounts for the 4th of human death's reason, is increasingly subject to the attention of society and national governments.AD is a kind of diffusivity Nervous centralis degenerative disease, characterized by progressive cognitive disorder, intelelectual deterioration and personality change, with Cerebral Amyloid egg White A β 1-42 depositions, neurofibrillary tangles, neuron loss and slow inflammatory pathologies.The cause of disease and pathogenesis of AD is still Not fully aware of, there are many theory at present about senile dementia mechanism study, have acetylcholine shortage theory, proteins toxic to sink Product theory, harmful free radicals damage theory etc..Clinically can behave as progressive impaired memory function, cognitive function it is disorderly and Behavioral aspect changes.Especially AD lacks objective efficiency index before death.The drug for the treatment of senile dementia on the market does not have also at present Reach highly satisfactory result.The drug for the treatment of AD mainly has (1) acetylcholine enzyme inhibitor (Acetyl at present cholinesterase inhibitors,AChEIs)；(2) nmda antagonist；(3) other Semagacestat (LY450139), ACC-001, rush metabolic drug, non-steroidal anti-inflammatory drugs, antioxidant, neural blood vessel conditioning agent, estrin treatment Deng.The effect of more than drug, sees generally.

Research work has made intensive studies the structure of Chinese medicine and pharmacodynamics etc. in recent years, finds many Chinese medicines and its carries Take object, such as polysaccharides, astragalus polyose, ginsenoside that all there is good immunoregulation effect, the mechanism of action is substantially By being carried to the adjusting of mononuclear macrophage, NK cells, T cell, B cell, cell factor and neuro-endocrine-immune network High body resistance against diseases, achieve the purpose that prevent and cure diseases (Sun Wei wide etc., 2001).Chinese patent CN105561108A, CN101797351A and CN97117052.5A etc. discloses the pharmaceutical composition of different several treatment senile dementias, these The composition of composition is to include rhodiola root, akebi, the fleece-flower root, Herba Epimedii, ginseng, grass-leaved sweetflag, pueraria lobata, Rhizoma Chuanxiong etc., is made each Kind peroral dosage form.Chinese patent CN200510002971.0A discloses a kind of Chinese medicine preparation for treating senile dementia, including Following Chinese medicine material：Prepared fleece flower root is processed into clear cream by prepared fleece flower root, lotus leaf, Herba Cistanches, earthworm, Radix Rhapontici seu Radix Echinopsis；Lotus leaf, Herba Cistanches, Radix Rhapontici seu Radix Echinopsis decocts extraction and clear cream is made；Dry cream is made in merging, and earthworm processing is made dry cream and merges again with aforementioned dry cream, and finished product is made. Chinese patent CN02112711.5A discloses a kind of composition of prevention senile dementia being made of Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis. The Chinese herbal product of above-mentioned treatment senile dementia is focused on adjusting too much, and relative reduction plays the drug proportion of therapeutic effect, Pharmic function performance is affected, so effect is slow, the course for the treatment of is long, and effect is less preferable.Chinese medicine is due to being mostly the decoction or ball boiled Agent takes difficulty compared with Western medicine, has also greatly affected the popularization of Chinese medicine.

Invention content

For overcome the deficiencies in the prior art, prevent or improve senile dementia the purpose of the present invention is to provide a kind of Composition and its application, the composition compatibility is scientific and reasonable, effectively prevent infringement of the free radical to human body, has to senile dementia There are prevention and improvement result well, preparation method is simple, and production cost is low, carries convenient, sweet and sour taste.

To solve the above problems, the technical solution adopted in the present invention is as follows：

A kind of composition prevented or improve senile dementia, including following raw material by weight：Ginseng pulverate 2-5 Part, 2-5 parts of Radix Notoginseng powder, 2-20 parts of hawthorn powder, 1-5 parts of wolfberry fruit powder, 1-5 parts of yam flour, 1-5 parts of Fructus Schisandrae Chinensis powder, Radix Polygalae powder 1-5 Part, 0.2-4.0 parts of sorosis powder, 0.05-1.1 parts of gingko powder, 0.1-2.5 parts of kudzu-vine root powder, 0.1-2.5 parts of rhizoma alismatis powder, walnut powder 0.1-2.5 parts, 0.2-1.6 parts of rhodiola root powder, 1-3 parts of astragalus membranaceus powder, 1-3 parts of raspberry powder, 1-3 parts of fructus alpiniae oxyphyllae powder, red date powder 5- 15 parts.

As the preferred embodiment of the present invention, composition of the invention includes following raw material by weight：Ginseng 2-4 parts of powder, 2-3 parts of Radix Notoginseng powder, 3-16 parts of hawthorn powder, 2-5 parts of wolfberry fruit powder, 2-5 parts of yam flour, 2-5 parts of Fructus Schisandrae Chinensis powder, Radix Polygalae powder 2-5 parts, 0.4-3.0 parts of sorosis powder, 0.05-1.5 parts of gingko powder, 0.1-2.4 parts of kudzu-vine root powder, 0.1-2.4 parts of rhizoma alismatis powder, walnut powder 0.1-2.4 parts, it is 0.2-1.5 parts of rhodiola root powder, 1-2.5 parts of astragalus membranaceus powder, 1-2.5 parts of raspberry powder, 1-2.5 parts of fructus alpiniae oxyphyllae powder, red 5-10 parts of date powder.

As the preferred embodiment of the present invention, composition of the invention includes following raw material：Ginseng pulverate 2g, Radix Notoginseng powder 2g, hawthorn powder 8g, wolfberry fruit powder 5g, yam flour 3g, Fructus Schisandrae Chinensis powder 4g, Radix Polygalae powder 2g, sorosis powder 0.5g, gingko powder 0.06g, pueraria lobata Powder 0.2g, rhizoma alismatis powder 0.4g, walnut powder 0.4g, rhodiola root powder 0.5g, astragalus membranaceus powder 1g, raspberry powder 1g, fructus alpiniae oxyphyllae powder 1g, jujube Powder 9g.

In above-mentioned formula, the ginseng pulverate is wild ginseng, artificial growth ginseng, Korean ginseng or American Ginseng powder or its Extract.

As the preferred embodiment of the present invention, composition of the invention further includes trace element, and the trace element is Magnesium, zinc, selenium are respectively in the content of composition：0.01~0.5mg/g of magnesium, 0.01~0.2mg/g of zinc, selenium 0.01~ 0.5mg/g。

It is further preferred that the magnesium is magnesium stearate, the zinc is zinc sulfate, zinc citrate, zinc lactate, glycine zine Or one kind in zinc gluconate；The one kind of the selenium in sodium selenite, selenoprotein or Se-enriched yeast.

The present invention also provides the medicines that composition as described above has the function of to prevent or improve senile dementia in preparation Application in product, health products, food.

Specifically, the drug is one kind in capsule, tablet, pulvis, granule or pill；The health products are solid One kind in body beverage, tea bag, oral liquid or health liquor；The food is cake, biscuit, candy, Yoghourt, hawthorn item, jelly Or one kind in mixed congee.

In above-mentioned formula, ginseng is the traditional rare Chinese medicine in China, belongs to Araliaceae herbaceous plant, has a variety of neural medicines Reason activity such as changes brain alkaloid, the learning ability promoting learning and memory ability, promote fatigue recovery, improving humans and animals, Enhance immunity of organisms.Water extracts from Ginseng has significant protective effect to the SH-SY5Y Apoptosis that amyloid beta induces, Ginsenoside can be obviously prolonged animal lifespan and cell survival, and can remove the free radical for causing aging in vivo and biomembrane is protected to exempt from It is damaged by free radical；Senile rat cardiac muscle, brain and liver tissues lipofuscin content are can obviously reduce, significantly reduces serum peroxidating Lipid, and the activity of superoxide dismutase can be improved.

Radix Notoginseng, sweet and slightly bitter taste is warm-natured, return liver warp, stomach, the heart channel of Hang-Shaoyin, lung channel, large intestine channel.Radix Notoginseng can promote blood circulation, It is often edible to reduce blood cholesterol and triglyceride, and hyperlipemia hypertension, apoplexy, angiocarpy etc. can be prevented Disease.The active constituent of Radix Notoginseng be the total soap of Radix Notoginseng, there is dissipate stasis of blood hemostasis, detumescence ding-tong, it can also be used to treat hemoptysis, It spits blood, have blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, falling swelling and pain etc..With the development for medical research, it is found that Radix Notoginseng not only has There are good hemostasis, promoting blood circulation and removing blood stasis, active two-way pharmacological action of promoting blood circulation, also with apparent blood tonification effect, can promote in blood All kinds of blood cell merisis such as red blood cell, leucocyte, blood platelet increase number, keep the effect of normal level, have simultaneously Have antithrombotic, protection cardiac muscle and prevent brain tissue impairment and expand blood vessel, increase brain and coronary blood flow, by blood fat, blood pressure lowering, The multiple pharmacological effects such as analgesia, anti-inflammatory, elimination free radical.

Hawthorn, warm-natured, acid sweet in flavor, Return liver, spleen, stomach, promoting digestion and removing indigestion, promoting blood circulation to remove blood stasis, for meat stagnation, abdominal pain is let out It rushes down, postpartum stasis, hernia pain, there is coronary artery dilator, vasodilator, blood fat-reducing blood pressure-decreasing cardiac stimulant.

Matrimony vine contains abundant polysaccharides, fat, protein, free amino acid, taurine, glycine betaine, vitamin B1, B2, E, C, particularly carotenoid content are very high；Additionally contain a large amount of mineral element.Matrimony vine has enriching yin and nourishing kidney, Brain tonic blood-nourishing, improving eyesight benefit god, anti-aging and other effects, are widely used in and adjust blood fat, resist oxygen lack, anti-oxidant, immunological regulation, benefit Blood, anti-aging, improves stomach function, antifatigue, enhancing development, improves eyesight etc. the protection of chemical damage.

Chinese yam, mild-natured, sweet in flavor, returns spleen, lung, kidney channel, tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying, for spleen eating less, Endless diarrhea, the deficiency syndrome of the lung are breathed with cough, emission due to the kidney deficiency, and under band, frequent micturition, abnormal heat is quenched one's thirst.Chinese yam contains the objects such as amylase, polyphenol oxidase Matter is conducive to taste digestion and absorption function；Chinese yam contains a large amount of mucus albumen, electrolytes and minerals, can effectively prevent Blood fat has effects that beneficial will calms the nerves, promotes longevity in the precipitation of vascular wall and reduction blood glucose, prevention cardiovascular diseases.

Schisandra chinensis, it is sour warm-natured, enter lung channel, kidney channel, the heart channel of Hang-Shaoyin, for chronic cough and dyspnea of deficiency type, injury thirst, spontaneous sweating, kidney deficiency Seminal emission, spleen kidney deficiency are rushed down, palpitation and insomnia.Schisandra chinensis is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis, Fruit contains schizandrin and vitamin C, resin, tannin and a small amount of carbohydrate；With astringe the lung to stop cough, nourish it is puckery essence, antidiarrheal hidroschesis it Effect.

Radix Polygalae, slightly warm in nature, bitter, acrid flavour enter the heart channel of Hang-Shaoyin, lung channel, kidney channel, have the function of tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence, For insomnia of palpitating with fear, dreaminess is forgetful, coma epilepsy, coughing with a lot of sputum, swollen ulcer drug.

Sorosis, it is sweet in flavor and cold in property, there is liver-kidney tonifying, ease constipation of promoting the production of body fluid, UFA eyesight and other effects, contain sugar, protein, fat Fat, malic acid, malic acid and vitamin A, vitamin B1, vitamin B2, vitamin C, iron, sodium, calcium, magnesium, phosphorus, potassium, carrotene and Anthocyanidin.The aliphatic acid of Fructus Mori oil is mainly made of linoleic acid and a small amount of stearic acid, oleic acid etc..Mulberries have improvement skin blood Supply, nutrition skin make skin delicate and the effects that black hair, and can slow down aging.In addition, mulberries have effect of gain to spleen, There is humidification to hemolytic reaction, human body artery hardening, skeletal joint hardening can be prevented, boost metabolism, promote blood red The growth of cell prevents Neuroleptic Leukocytopenia, and to treatment diabetes, anaemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia etc. Illness has effects that auxiliary.

Gingko, also known as ginkgo, it is sweet in flavor, bitter, puckery, it is mild-natured, it is slightly poisonous.Distributed in lung channel, kidney channel.Function：Astringing lung for relieving asthma, stop-band contracting Urine；It cures mainly：Asthma phlegm is coughed, leukorrhea, gonorrhoea, seminal emission, frequent micturition, nameless sores or boils, Zha nose, tinea sore.Flavonoid glycoside in gingko benevolence and Amarolide also has the diseases such as cerebral thrombus, senile dementia, hypertension, hyperlipidemia, coronary heart disease, artery sclerosis, Aging There is special prevention and treatment effect.

Pueraria lobata, cool in nature, acrid-sweet flavor, returns spleen stomach.Principal solution flesh is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.Research shows that pueraria lobata There is apparent therapeutic effect to learning memory disorder, available for treating the illnesss such as senile dementia, dysnoesia, poor memory. Kudzu-vine root powder contains 12% flavone compound, such as Puerarin, daizeol glycosides, peanut element nutritional ingredient, also protein, ammonia The minerals such as base acid, sugared and iron needed by human, calcium, copper, selenium.

Rhizoma alismatis, it is sweet in flavor, it is cold in nature, return kidney, bladder warp, have effects that clearing damp and promoting diuresis, expel the heat-evil it is treating stranguria.

Walnut, it is sweet in flavor, it is warm-natured, return kidney, lung, large intestine channel, there is replenishing kidney, strengthening waist, warm lung Dingchuan, relax bowel, use In pain in the back flaccidity of lower limbs, long void syndrome characterized by dyspnea, dry constipation of intestines.

Rhodiola root, mild-natured, sweet in flavor, bitter, distributed in lung channel, the heart channel of Hang-Shaoyin has effects that qi and activate blood circulation, promotes blood circulation and relievings asthma, for the deficiency of vital energy Blood stasis, chest impediment and cardialgia, hemiplegia, burnout asthma.

Radix Astragali, sweet in flavor, tepor, returns spleen, lung channel, have invigorating qi for consolidating superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration, inducing diuresis for removing edema work( Effect, for treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, from juice night sweat, blood deficiency chlorosis, cloudy subcutaneous ulcer overflows swollen, deficiency of vital energy water It is swollen, Heat Diabetes.

Raspberry, it is sweet in flavor, sour, it is warm-natured, return liver and kidney channel, there is astringent sperm contracting urine, kidney-nourishing nourishing the liver, for passing out semen, urine Frequently, the enuresis, impotence.

Fructus alpiniae oxyphyllae, acrid flavour is warm-natured, returns spleen, kidney channel, has effects that warming spleen and stopping diarrha, warm kidney astringent sperm contracting urine, is spat for abdominal pain It rushes down, the more salivas of deficiency of food, the enuresis of passing out semen.

Jujube, sweet in flavor nontoxic, main heart perverse trend support spleen in peace, and flat stomach gas leads to nine orifices, help 12 warps, embellish lung, and cough-relieving is mended The five internal organs, governance wasting, except stomach addiction gas.Jujube contain protein, a variety of amino acid, carrotene, vitamin A, B2, C, P, irony, Calcareous, phosphorus matter etc. is beneficial to liver.

In the mentioned component of the present invention, pueraria lobata and gingko can be by influencing the level of interior free yl and with excellent Anti-free radical effects, and wolfberry fruit powder, red date powder and mulberries powder clear up free radical, slow down aging the effect of on kudzu-vine root powder There is synergistic effect with gingko powder；This five tastes ingredient of gingko powder, mulberries powder, kudzu-vine root powder, yam flour, astragalus membranaceus powder is improving painstaking effort Pipe enhances immune, promotion memory use with synergistic enhancing effect.In addition, gingko powder can influence Radical Metabolism, it is right Gently, moderate dementia patient has significant effect；Schisanhenol has significantly brain synaptosome big caused by oxygen radical and mitochondria Protective effect, available for slowing down aging, preventing senile dementia；Rhodiola essence can significantly improve the learning and memory barrier of dementia rats Hinder, suppress denaturation and the apoptosis of hippocampal neuron, be conducive to radicals scavenging system and prevent AD.

Compared with prior art, the beneficial effects of the present invention are：

The present invention is that applicant is established in the mechanism of Chinese tradition integration of drinking and medicinal herbs and Central nervous system senile dementia It is pathogenetic study for a long period of time on the basis of, with reference to a large amount of achievement in research of modern Chinese medicine pharmacy drug pharmacology both at home and abroad and Documents and materials have consulted and can be used for the plant Chinese herbal medicine of food or vegetables and fruits class from the integration of drinking and medicinal herbs that tens kinds of Ministry of Public Health announce Essence dry powder data is therefrom filtered out to removing free radical effectively with raising body immunity, the plant that can promote longevity By the multiple Experimental comparison repeatedly of applicant research team, it is good to find out mouthfeel for class Chinese herbal medicine or vegetables and fruits class essence dry powder type Delicious formula produces the composition that the suitable middle-aged and the old eats by the production method of industrialized standard, to prevention or Improve senile dementia and obtain certain effect.

The composition of the present invention can restrain injury of the free radical to cell, safeguard the normal operation of human body various functions, increase Strong muscle power, Eradicates disease health cares retain youthful vitality, and can keep fit and healthy, prevent old brain tonic, kidney tonifying enriching yin, adjust hormonal secretion, change The function of kind the elderly's physiological metabolism, enhances memory of elderly person brain function, has prevention well to senile dementia and improves and makees With, and convenient, sweet and sour taste is carried, meet the eating habit of the elderly.

Specific embodiment

The present invention is described in further detail With reference to embodiment.

Wherein, ginseng pulverate is the powder or its extract of wild ginseng, artificial growth ginseng, Korean ginseng or American Ginseng.This The composition of invention further includes trace element, and the trace element is magnesium, zinc, selenium, is respectively in the content of composition：Magnesium 0.01~0.5mg/g, 0.01~0.2mg/g of zinc, 0.01~0.5mg/g of selenium.Magnesium is magnesium stearate, and zinc is zinc sulfate, citric acid One kind in zinc, zinc lactate, glycine zine or zinc gluconate；Selenium in sodium selenite, selenoprotein or Se-enriched yeast one Kind.

Table 1 is applicant in the optimization formula obtained after repetitious experiment.

The component and its dosage that table 1 is respectively formulated

Composition	It is formulated a dosage (g)	It is formulated two dosages (g)	It is formulated three dosages (g)
				Ginseng pulverate	2	1.5	1.2
Radix Notoginseng powder	2	1.5	1.2
				Hawthorn powder	8	6	5
Wolfberry fruit powder	5	5	4
				Yam flour	3	3	2
Fructus Schisandrae Chinensis powder	4	3	3
				Radix Polygalae powder	2	2	3
Sorosis powder	0.5	1.5	3
				Gingko powder	0.06	0.6	1
Kudzu-vine root powder	0.2	1.2	2
				Rhizoma alismatis powder	0.4	1.4	2
Walnut powder	0.4	1.4	2
				Rhodiola root powder	0.5	1	1.5
Astragalus membranaceus powder	1	2	1.5
				Raspberry powder	1	2	1.5
Fructus alpiniae oxyphyllae powder	1	2	1.5
				Red date powder	9	4	6
Altogether	39.66	39.1	39.9

Embodiment 1:

By in table 1 formula one formula rate be configured to 100 kilograms of mixing powders, after mixing add in trace element after Then medicinal preparation for oral administration is conventionally made in continuous mixing, dry sterilization, such as capsule, tablet, pulvis, particle, pill, Gu Body beverage, tea bag.

Embodiment 2:

By in table 1 formula one formula rate be configured to 100 kilograms of mixing powders, after mixing add in trace element after Then oral liquid or health care wine liquid is conventionally made in continuous mixing, dry sterilization.

Embodiment 3:

100kg mixing powders are configured in the ratio of formula two in table 1, trace element is added in after mixing and continues to mix It is even, it is packed after dry sterilization, every bag of 150g, takes above-mentioned 1 bag of 150g mixed powder, be uniformly mixed with 1500g Self- raising flour, with suitable Amount egg, milk, baking powder, sugar are made with the cake for preventing or improving senile dementia effect.

Embodiment 4:

100kg mixing powders are configured in the ratio of formula two in table 1, along with the Poria cocos of equivalent, Gorgon fruit, hyacinth bean, the heart of a lotus seed Rice, lotus-seed kernel, glutinous rice, polished rice are ground into fine powder, add in trace element after mixing and continue mixing, pack, make after dry sterilization Into health care powder or solid beverage, eaten for the middle-aged and the old.

Embodiment 5:

100kg mixing powders are configured in the ratio of formula three in table 1, along with the hawthorn powder of equivalent, mix, cook, Mashing, molding, drying, packaging, are made with the hawthorn item for preventing or improving senile dementia effect.

Compliance test result：

By using the composition of the present invention as experimental group, it is of the invention to just using brain rehabilitation piece as positive controls research Normal mouse and SAMP8 presenility mouse Jumping test, the Y types water maze and influence for growing survival period, specific experiment process are as follows：

Positive drug：Piracetam Tablet (piracetam, manufacturer：Hubei Huahzong Medicine Co., Ltd, lot number： 20060812,0.4g/ pieces, people's dosage are 4.8g/kg/d)

Experimental animal：SAMP8 presenility mouse, SAMR1 normal mouses, half male and half female, 18-22g, 7 monthly ages.

Laboratory apparatus：Electronic balance (model：AL104, Mettler-Toledo Instrument (Shanghai) Co., Ltd.)；Crude drug Object isolates and purifies device (BUCHI Syncore)；Mouse diving tower instrument (XZC-5Q types, Shandong Academy of Medical Sciences's maintenance of equipment supply It stands)；Y type water mazes.

Data statistics：The data of each group are represented with X ± SD, are analyzed using single factor test variance test；It is examined between two groups with t It tests and is analyzed.

Contrast experiment one：Influence of the present invention to normal mouse and SAMP8 presenility mouse Jumping tests

The mixing powder 2g being prepared in inventive formulation one to three is respectively taken, 20 times are separately added into each mixing powder Distilled water be made into stoste 1, stoste 2, stoste 3.

50 mouse are taken, are randomly divided into 5 groups, (10 SAMR1 mouse are just for every group of 10 animals, respectively Normal group Normal physiological saline 40ml/kg gavages), positive drug control group (0.72g/kg gavages), control group (SAMP8 mouse normal physiologicals Brine 40ml/kg gavages), experimental group 1 (stoste 1), experimental group 2 (stoste 2), experimental group 3 (stoste 3), with oral administration gavage in morning Mode to mouse successive administration 20 days, the dosage gavage of 40ml/kg, once a day, the 20th day starts to train.The 1h before training Give drug.Every batch of experiment each group has 1 mouse to be administered, operation repetitive, and so on.By first 5 mouse during training It being respectively put into 5 grid of diving tower instrument, first adapts to environment 3min, be then electrified to, after mouse is shocked by electricity, majority jumps onto diving tower, Escape electric shock.Copper grid are contacted to get an electric shock using mouse biped simultaneously when animal majority jumps off platform again, are considered as wrong reaction, training 5min, and electric shock number in 5min is recorded, it retests afterwards for 24 hours, is recorded and tested as observation index using incubation period and electric shock number Achievement.

2 Jumping test result of table

Group	Training achievement (errors number)	Incubation period (second)	Performance of the test (errors number)
				Normal group (SAMR1)	4.3±2.7**	221.3±111.6**	2.3±1.9**
Positive drug control	8.9±3.5	189.4±100.9*	4.5±1.2**
				Experimental group 1	9.6±2.6	178.3±110.8*	3.6±2.5*
Experimental group 2	10.5±3.5	169.6±120.6*	3.9±2.4*
				Experimental group 3	9.3±3.6	178.6±110.5*	4.9±2.1*
Control group	12.5±3.7	150.6±120.3	10.9±3.8

* P compared with the control group<0.05, * * P compared with the control group<0.01

Experiment conclusion：

The experimental results showed that the Jumping test knot of positive drug control group, experimental group 1 (stoste 1) to experimental group 3 (stoste 3) Fruit is than control group there were significant differences (P<0.05) ability of learning and memory for, illustrating to take mouse after the present composition improves. The Jumping test result of experimental group 1 (stoste 1) is than positive drug control group, experimental group 2 (stoste 2), experimental group 3 (stoste 3) It is good.

Contrast experiment two:Influence of the present invention to normal mouse and SAMP8 mouse aging Y type water maze laboratories

50 mouse are taken, are randomly divided into 5 groups, (10 SAMR1 mouse are just for every group of 10 animals, respectively Normal group Normal physiological saline 40ml/kg gavages), drug-positive control group (0.72g/kg gavages), control group (SAMP8 mouse normal physiologicals Brine 40ml/kg gavages), experimental group 1 (stoste 1), experimental group 2 (stoste 2), experimental group 3 (stoste 3), with oral administration gavage in morning Mode to mouse successive administration 20 days, the dosage gavage of 40ml/kg, once a day, the 20th day starts to train.It was administered in 20 days 1h proceeds by Y type water maze trainings afterwards.Mouse be placed on 27 ± 2 DEG C of water temperature, depth of water 10cm Y type water mazes in, side has flat Platform arrived at platform as correct response using mouse in 15 seconds, rests 10 seconds after arrival platform and repeats training, every mouse is instructed altogether Practice 10 times, calculate its correct response rate, it is tested after 24 hours and remembers holding situation, its memory consolidation feelings is tested after 48 hours Condition.Using the average value of the correct response rate of 10 mouse in same group as the final result of the group, 3 are the results are shown in Table.

Table 3Y type water maze laboratory results

Group	First day correct response rate	Second day correct response rate	Third day correct response rate
				Normal group (SAMR1)	94%**	92%**	95%**
Drug-positive compares	90%*	91%**	92%**
				Experimental group 1	87%*	84%*	88%*
Experimental group 2	89%*	87%*	89%*
				Experimental group 3	82%*	86%*	85%*
Control group	61%	65%	68%

Experiment conclusion：The experimental results showed that drug-positive control group, the Y of experimental group 1 (stoste 1) to experimental group 3 (stoste 3) Type water maze laboratory result is than control group there were significant differences (P<0.05), illustrate to take the study note of mouse after the present composition The ability of recalling improves.The Y type water maze laboratories result of experimental group 2 (stoste 2) slightly than drug-positive control group difference but compares experimental group 1,3 (stostes 1,3) are good.

Contrast experiment three:Influence of the present invention to normal mouse and SAMP8 mouse aging survival periods

The mixing powder 2g being prepared in inventive formulation one to three is respectively taken, 20 times are separately added into the drug Distilled water is made into stoste 1, stoste 2, stoste 3.

50 mouse are taken, are randomly divided into 5 groups, (10 SAMR1 mouse are just for every group of 10 animals, respectively Normal group Normal physiological saline 40ml/kg gavages), drug-positive control group (0.72g/kg gavages), control group (SAMP8 mouse normal physiologicals Brine 40ml/kg gavages), experimental group 1 (stoste 1), experimental group 2 (stoste 2), experimental group 3 (stoste 3), with the side of oral administration gavage Formula is observed after mouse is discontinued to mouse successive administration 20 days, the dosage gavage of 40ml/kg and grows to death, record every later The growth survival period of mouse, using the average value of the growth survival period of 10 mouse in same group as the final result of the group.

Table 4 grows survival period experimental result

Group	Growth survival period (my god)
		Normal group (SAMR1)	98
Positive drug control group	68*
		Experimental group 1	62**
Experimental group 2	58**
		Experimental group 3	65**
Control group	49

Experiment conclusion：The experimental results showed that positive drug control group, experimental group 1 (stoste 1) are to experimental group 3 (stoste 3) Survival period experimental result is grown than control group there were significant differences (P<0.05), illustrating to take can be effective after the composition of the present invention Extend the growth survival period of the mouse with senile dementia.The growth survival period experimental result of experimental group 3 (stoste 3) is than positive Drug control group is slightly worse, but better than experimental group 1,2 (stoste 1,2).

By test above and its result it is found that the present invention composition can significantly improve the mouse with senile dementia Learning and memory function, extend senile dementia mouse survival period, illustrate the present invention composition can restrain free radical pair The normal operation of human body various functions, enhancing muscle power are safeguarded in the injury of cell, and Eradicates disease health cares retain youthful vitality, and energy salubrity is good for Body, the function preventing old brain tonic, kidney tonifying enriching yin, adjust hormonal secretion, improving the elderly's physiological metabolism, enhance memory of elderly person Brain function has senile dementia prevention and improvement result well,

The above embodiment is only the preferred embodiment of the present invention, it is impossible to the scope of protection of the invention is limited with this, The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention Claimed range.

Claims

1. a kind of composition prevented or improve senile dementia, it is characterised in that：Including following raw material by weight：People Join 2-5 parts of powder, 2-5 parts of Radix Notoginseng powder, 2-20 parts of hawthorn powder, 1-5 parts of wolfberry fruit powder, 1-5 parts of yam flour, 1-5 parts of Fructus Schisandrae Chinensis powder, Radix Polygalae 1-5 parts of powder, 0.2-4.0 parts of sorosis powder, 0.05-1.1 parts of gingko powder, 0.1-2.5 parts of kudzu-vine root powder, 0.1-2.5 parts of rhizoma alismatis powder, walnut 0.1-2.5 parts of powder, 0.2-1.6 parts of rhodiola root powder, 1-3 parts of astragalus membranaceus powder, 1-3 parts of raspberry powder, 1-3 parts of fructus alpiniae oxyphyllae powder, red date powder 5-15 parts.

2. prevention according to claim 1 or the composition of improvement senile dementia, it is characterised in that：Including below by weight Measure the raw material of part meter：2-4 parts of ginseng pulverate, 2-3 parts of Radix Notoginseng powder, 3-16 parts of hawthorn powder, 2-5 parts of wolfberry fruit powder, 2-5 parts of yam flour, five 2-5 parts of taste powder, 2-5 parts of Radix Polygalae powder, 0.4-3.0 parts of sorosis powder, 0.05-1.5 parts of gingko powder, 0.1-2.4 parts of kudzu-vine root powder, rhizoma alismatis 0.1-2.4 parts of powder, 0.1-2.4 parts of walnut powder, 0.2-1.5 parts of rhodiola root powder, 1-2.5 parts of astragalus membranaceus powder, 1-2.5 parts of raspberry powder, 1-2.5 parts of fructus alpiniae oxyphyllae powder, 5-10 parts of red date powder.

3. prevention according to claim 1 or the composition of improvement senile dementia, it is characterised in that：Including following original Material：Ginseng pulverate 2g, Radix Notoginseng powder 2g, hawthorn powder 8g, wolfberry fruit powder 5g, yam flour 3g, Fructus Schisandrae Chinensis powder 4g, Radix Polygalae powder 2g, sorosis powder 0.5g, gingko powder 0.06g, kudzu-vine root powder 0.2g, rhizoma alismatis powder 0.4g, walnut powder 0.4g, rhodiola root powder 0.5g, astragalus membranaceus powder 1g, basin is covered Sub- powder 1g, fructus alpiniae oxyphyllae powder 1g, red date powder 9g.

4. prevention described in any one of claim 1 to 3 or the composition of improvement senile dementia, it is characterised in that： The ginseng pulverate is the powder or its extract of wild ginseng, artificial growth ginseng, Korean ginseng or American Ginseng.

5. prevention described in any one of claim 1 to 3 or the composition of improvement senile dementia, it is characterised in that： Trace element is further included, the trace element is magnesium, zinc, selenium, is respectively in the content of composition：0.01~0.5mg/g of magnesium, 0.01~0.2mg/g of zinc, 0.01~0.5mg/g of selenium.

6. prevention according to claim 5 or the composition of improvement senile dementia, it is characterised in that：The magnesium is tristearin Sour magnesium, the zinc are one kind in zinc sulfate, zinc citrate, zinc lactate, glycine zine or zinc gluconate；The selenium is selected from One kind in sodium selenite, selenoprotein or Se-enriched yeast.

7. the medicine that composition according to any one of claims 1 to 3 has the function of to prevent or improve senile dementia in preparation Application in product, health products, food.

8. application according to claim 7, it is characterised in that：The drug for capsule, tablet, pulvis, granule or One kind in pill；The health products are one kind in solid beverage, tea bag, oral liquid or health liquor；The food for cake, One kind in biscuit, candy, Yoghourt, hawthorn item, jelly or mixed congee.