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CN108186503A - A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof - Google Patents

A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof Download PDF

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Publication number
CN108186503A
CN108186503A CN201810249927.7A CN201810249927A CN108186503A CN 108186503 A CN108186503 A CN 108186503A CN 201810249927 A CN201810249927 A CN 201810249927A CN 108186503 A CN108186503 A CN 108186503A
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China
Prior art keywords
extract
parts
component
magnolia binodii
whitening
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Pending
Application number
CN201810249927.7A
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Chinese (zh)
Inventor
解勇
刘裕娇
罗财通
王雅琴
杨悬
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Cosmetics Co Ltd Guangdong Sheng Mei
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Cosmetics Co Ltd Guangdong Sheng Mei
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Priority to CN201810249927.7A priority Critical patent/CN108186503A/en
Publication of CN108186503A publication Critical patent/CN108186503A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/614Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
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    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
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    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82Preparation or application process involves sonication or ultrasonication

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Abstract

The present invention discloses a kind of whitening emulsion of extract containing Magnolia binodii, including component A, B component, component C;The preparation method of the lotion includes the component A for 1) weighing formula ratio, puts into water phase pot, is heated with stirring to 80 85 DEG C, makes its dissolving complete, spare;2) B component of formula ratio is weighed, is put into oil phase pot, is heated with stirring to 65 75 DEG C, makes its dissolving complete, it is spare;3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made in oil phase material sucking emulsifying kettle, and 1 5min of homogeneous continues stirring cooling;4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;5) when temperature is dropped to below 40 DEG C, filtering and discharging.Whitening emulsion of the present invention can meet the needs of people are to natural, skin whitening, healthy skin care item.Invention also provides the preparation methods of the whitening emulsion.

Description

A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof
Technical field
Whitening emulsion the present invention relates to a kind of extract containing Magnolia binodii and preparation method thereof belongs to cosmetic art neck Domain.
Background technology
East aesthetic conceptions are with Bai Weimei, and from ancient times to the present, people never stopped the pursuit of pale skin, whitening flesh Skin, which is always woman, to be continually striving to and perfect primary standard.The quickening of particularly present live and work rhythm, Hen Duoshang Race of class against computer and mobile phone, causes daily life system disorderly, skin will it is easy to appear dark yellow dark and gloomy situation, maids everyday People, which looks at, to be old for one's age much, and beauty is allowed to have a greatly reduced quality.For a long time, have a significant impact to the self-confidence of women, as people consume The maturation of idea, consumer is not only both effectiveness at its to skin-lightening cosmetic focal point, while more focuses on its safety, plant The natural whitening agent in source has many advantages, such as safe, mild, lasting, efficient.
Flos micheliae Albae also known as Magnolia binodii, the dry flower also known as the flower bud of lily magnolia of the plant Magnolia binodii of Magnoliaceae have for China more than 2000 The traditional flowers and Chinese medicine of year history, bright in colour, bud is compact, and palea is neat, and fragrance is strong.The flower bud of lily magnolia has the work(of dispersing wind and cold Effect, for controlling rhinitis, blood pressure lowering etc..Zhang Huajian etc. studies 10 taste Chinese medicines involved in " the seven white cream " in different documents Shi Faxian, the flower bud of lily magnolia are the most it will be evident that can reduce melanin simultaneously in these medicinal materials to melanocyte proliferation inhibiting effect Generation, also has effects that oxidation resistant.
At present, Chinese patent " a kind of whitening emulsion and preparation method thereof " (publication number CN107184528A), is related to one kind Whitening emulsion and preparation method thereof;The whitening emulsion is made of following raw material:Licorice, snake woman extract, rose Rare water, royal jelly, olive oil and deionized water;A kind of preparation method of whitening emulsion, includes the following steps:1) licorice Preparation;2) preparation of snake woman extract;3) raw material mixes.By Radix Glycyrrhizae and snake woman, both have skin the present invention There is the compatibility between whitening and the Chinese herbal medicine of maintenance function, enhance respective effect so that whitening effect enhances;Raw material is day The ingredient so having no stimulation, can reach skin whitening, moisturizing effect and, can be used for a long time.
Also Chinese patent " a kind of cosmetics whitening emulsion and preparation method thereof " (application number 201610172347.3), should Whitening emulsion includes following component by mass percentage:Glycyrrhiza glabra root extract 0.0015~0.2, niacinamide 0.1~ 10, moutan root bark extract 0.1~5, pale flag root extract 0.1~10;Other cosmetic emulsions often use matrix components 60%~80%.
Chinese patent " a kind of whitening emulsion and preparation method thereof " (application number 201410514648.0), whitening emulsion includes The component of following parts by weight:10-20 parts of olive oil, 4-10 parts of hexadecanol, 5-10 parts of vaseline, 5-10 parts of propylene glycol, saualane 10-20 parts, 2-10 parts of ursin, 10-20 parts of xanthic acid number glue, 4-10 parts of beeswax, 4-6 parts of essence, 1-2 parts of preservative and distillation 100-200 parts of water.
Current whitening emulsion, it is impossible to effectively meet the needs of people are to natural, skin whitening, healthy skin care item.
Invention content
In view of the above existing problems in the prior art, the present invention provides a kind of whitening emulsion of extract containing Magnolia binodii, can Meets the needs of people are to natural, skin whitening, healthy skin care item.Invention also provides the preparation sides of the whitening emulsion Method.
To achieve these goals, the whitening emulsion of a kind of extract containing Magnolia binodii that the present invention uses, by weight, Specifically include following components,
Component A:1-5 parts of emulsifier, 5-15 parts of grease, 0.1-5 parts of preservative;
B component:5-20 parts of polyalcohol, 0.01-0.5 parts of allantoin, 0.1-2 parts of thickener, 40-65 parts of deionized water;
Component C:0.01-5 parts of Magnolia binodii extract, 0.01-1 parts of tranexamic acid, 0.1-1 parts of amino acid whitening agent, ubiquinone 0.01-0.5 parts, 0.01-0.1 parts of Sodium Hyaluronate, 0.01-0.1 parts of beta glucan, -51 0.01-1 parts of polyquaternium, nerve 3 0.01-1 parts of amide, 0.5-5 parts of hazel extract, 0.01-1 parts of cynara scolymus leaf extract, 0.01-1 parts of gorgonian extract, 0.01-1 parts of orange peel extract hydrolyzes European 0.01-1 parts of Lee, 0.01-1 parts of greater plantain seed extract, acrophyta extraction 0.01-1 parts of object, 0.01-1 parts of vapour bar jail, double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae -0.01-1 parts of dicarboxylic ester, three ethyl alcohol 0-0.6 parts of amine, 0.001-1 parts of didextrose base gallate, 0.01-0.1 parts of essence.
The emulsifier is hard using cetostearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, glycerine One or more mixing in resin acid ester, sucrose stearate, PEG-40 stearates, ceteareth -20.
The grease is dimethyl silicone polymer, phytosterol isostearate, isohexadecane, tridecanol trimellitic acid Ester, isopropyl myristate, caprylic/capric triglyceride, Nexbase 2004, Butyrospermum parkii fruit fat, cyclopentasiloxane, fructus rosae One or more mixing of oil, isononyl isononanoate.
The preservative is 1,2- hexylene glycols, parahydroxyacet-ophenone, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea, iodine One or more mixing in propilolic alcohol butyl mephenesin Carbamate, Sensiva SC50, methyl hydroxybenzoate or Nipasol.
The polyalcohol is glycerine, one or more mixing in butanediol, 1,3- propylene glycol.
The thickener for hydroxyethyl cellulose, xanthans, carbomer, one kind in acrylic acid (ester) analog copolymer sodium or A variety of mixing.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than for (1-3):The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating Extraction, 45-50 DEG C of bath temperature, ultrasonic time 1-2 hours is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.
It is the gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Notogineng Extract, wild rose extract, red The mixed proportion of peony extract is 3:3:2:2:2:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 80-85 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, puts into oil phase pot, is heated with stirring to 65-75 DEG C, makes its dissolving complete, it is standby With;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 1-5min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Compared with prior art, the beneficial effects of the invention are as follows:
1) whitening emulsion of the invention uses acrophyta extract, using the herbaceous plant of Yunnan high mountain as raw material, according to The prescription thought of Traditional Chinese Medicine " monarch minister, helps, makes " is allocated meticulously.Wherein, monarch pitches the stem of noble dendrobium with gold, and nourishing Yin and promoting production of body fluid grows water moisturizing; Minister is with Radix Angelicae Sinensis, nourshing blood and promoting blood circulation;Assistant is with Verbena officinalis, promoting blood circulation to remove blood stasis;Make with Radix Notoginseng, nourshing blood and promoting blood circulation, wild rose heat clearing and blood circulation promoting dissipates the stasis of blood, red Chinese herbaceous peony promoting blood circulation to remove blood stasis promotes metabolism.High mountain, which plants extraction skin-protecting factor, to be had good antioxidant activity and inhibits tyrosinase activity, And the effect of skin microcirculation is can effectively improve, the good raising colour of skin can be played, improve the effect of skin glossiness.
2) whitening emulsion of the invention is other than acrophyta skin-protecting factor, the cooperation Chinese tradition Chinese herbal medicine flower bud of lily magnolia, that is, lily magnolia Bud/flower extract of section's plant Magnolia binodii is as whitening agent, by ultrasonic extraction by the effective active in Magnolia binodii bud/spend Ingredient extracts at a lower temperature, avoids destroying its active whitening composition under high temperature, whitening effect is more notable.
3) whitening emulsion of the invention is other than containing Magnolia binodii bud/flower extract, reasonably combined hazel extract, The functional components such as cynara scolymus leaf extract, gorgonian extract, orange peel extract, European Lee of hydrolysis, greater plantain seed extract, Energy effective activation nourishes skin, delaying skin aging while whitening.
4) whitening emulsion of the invention is using Magnolia binodii extract, and Magnolia binodii is rich in flavones, volatile oil and lignanoid, In, total flavonoids substance has antioxidant activity, has good Scavenging activity to hydroxyl radical free radical and DPPH free radicals, with general Shandong Scholar's indigo plant photometry also indicates that it with stronger reducing power, Magnolia binodii extract can by inhibiting the activity of tyrosinase, from And with apparent whitening function, the effect of the good raising colour of skin can be played, improve skin glossiness, while can significantly it subtract Few free radical s, effectively inhibits tyrosinase activity, and prevent melanin transfer.
Specific embodiment
Understand to make the object, technical solutions and advantages of the present invention clearer, below by embodiment, to the present invention into Row is further described.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, and do not have to In limiting the scope of the invention.
Unless otherwise defined, all technical terms and scientific terms used herein are led with belonging to the technology of the present invention The normally understood meaning of technical staff in domain is identical, and used term is intended merely to retouch in the description of the invention herein State the purpose of specific embodiment, it is not intended that in the limitation present invention.
A kind of whitening emulsion of extract containing Magnolia binodii, by weight, specifically includes following components,
Component A:1-5 parts of emulsifier, 5-15 parts of grease, 0.1-5 parts of preservative;
B component:5-20 parts of polyalcohol, 0.01-0.5 parts of allantoin, 0.1-2 parts of thickener, 40-65 parts of deionized water;
Component C:0.01-5 parts of Magnolia binodii extract, 0.01-1 parts of tranexamic acid, 0.1-1 parts of amino acid whitening agent, ubiquinone 0.01-0.5 parts, 0.01-0.1 parts of Sodium Hyaluronate, 0.01-0.1 parts of beta glucan, -51 0.01-1 parts of polyquaternium, nerve 3 0.01-1 parts of amide, 0.5-5 parts of hazel extract, 0.01-1 parts of cynara scolymus leaf extract, 0.01-1 parts of gorgonian extract, 0.01-1 parts of orange peel extract hydrolyzes European 0.01-1 parts of Lee, 0.01-1 parts of greater plantain seed extract, acrophyta extraction 0.01-1 parts of object, 0.01-1 parts of vapour bar jail, double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae -0.01-1 parts of dicarboxylic ester, three ethyl alcohol 0-0.6 parts of amine, 0.001-1 parts of didextrose base gallate, 0.01-0.1 parts of essence.
Wherein, beta glucan can help to update and repair nervous skin, effectively reduce wrinkle of skin and red blood silk, enhance Cutaneous immunisation power promotes the healing and regeneration of scar, improves the moisture retention of skin and the smoothness that compacts.
The allantoin can effectively cure damage and stasis of blood trace, accelerate cytothesis, have anti-inflammatory, antiallergic, moisturizing, soft flesh The effect of skin.The Sodium Hyaluronate can effectively moisturizing skin, repair skin, penetrate into skin epidermis, promote skin The supply of nutrition.
The essence uses daily chemical essence, increases product pleasure degree.
The emulsifier is hard using cetostearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, glycerine One or more mixing in resin acid ester, sucrose stearate, PEG-40 stearates, ceteareth -20.
The grease is dimethyl silicone polymer, phytosterol isostearate, isohexadecane, tridecanol trimellitic acid Ester, isopropyl myristate, caprylic/capric triglyceride, Nexbase 2004, Butyrospermum parkii fruit fat, cyclopentasiloxane, fructus rosae One or more mixing of oil, isononyl isononanoate.
The preservative is 1,2- hexylene glycols, parahydroxyacet-ophenone, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea, iodine One or more mixing in propilolic alcohol butyl mephenesin Carbamate, Sensiva SC50, methyl hydroxybenzoate or Nipasol.
The polyalcohol is glycerine, one or more mixing in butanediol, 1,3- propylene glycol.
The thickener for hydroxyethyl cellulose, xanthans, carbomer, one kind in acrylic acid (ester) analog copolymer sodium or A variety of mixing.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than for (1-3):The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating Extraction, 45-50 DEG C of bath temperature, ultrasonic time 1-2 hours is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.
It is the gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Notogineng Extract, wild rose extract, red The mixed proportion of peony extract is 3:3:2:2:2:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 80-85 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, puts into oil phase pot, is heated with stirring to 65-75 DEG C, makes its dissolving complete, it is standby With;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 1-5min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Embodiment 1
A kind of whitening emulsion of extract containing Magnolia binodii, by weight, specifically includes following components,
Component A:1 part of emulsifier, 5 parts of grease, 0.1 part of preservative;
B component:5 parts of polyalcohol, 0.01 part of allantoin, 0.1 part of thickener, 40 parts of deionized water;
Component C:0.01 part of Magnolia binodii extract, 0.01 part of tranexamic acid, 0.1 part of amino acid whitening agent, 0.01 part of ubiquinone, thoroughly Bright 0.01 part of matter acid sodium, 0.01 part of beta glucan, 0.01 part of polyquaternium -51,0.01 part of Cer NP, witch hazel extraction 0.5 part of liquid, 0.01 part of cynara scolymus leaf extract, 0.01 part of gorgonian extract, 0.01 part of orange peel extract hydrolyze European Lee 0.01 part, 0.01 part of greater plantain seed extract, 0.01 part of acrophyta extract, 0.01 part of vapour bar jail, double-diethoxy two is sweet Alcohol hexamethylene Isosorbide-5-Nitrae -0.01 part of dicarboxylic ester, 0.1 part of triethanolamine, 0.001 part of didextrose base gallate, 0.01 part of essence.
The emulsifier uses cetostearyl alcohol.The grease is dimethyl silicone polymer.
The preservative is 1,2- hexylene glycols, parahydroxyacet-ophenone is according to 1:1 mixing.
The polyalcohol is glycerine.The thickener is hydroxyethyl cellulose.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than being 1:The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating and carries It takes, 45 DEG C of bath temperature, ultrasonic time 1 hour is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.The gold fork Herba Dendrobii extract, angelica extract, Verbena officinalis extraction Object, Notogineng Extract, wild rose extract, radix paeoniae rubrathe medicament extract mixed proportion be 3:3:2:2:2:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 80 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, is put into oil phase pot, is heated with stirring to 65 DEG C, makes its dissolving complete, it is spare;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 1min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Embodiment 2
A kind of whitening emulsion of extract containing Magnolia binodii, by weight, specifically includes following components,
Component A:5 parts of emulsifier, 15 parts of grease, 5 parts of preservative;
B component:20 parts of polyalcohol, 0.5 part of allantoin, 2 parts of thickener, 65 parts of deionized water;
Component C:5 parts of Magnolia binodii extract, 1 part of tranexamic acid, 1 part of amino acid whitening agent, 0.5 part of ubiquinone, Sodium Hyaluronate 0.1 part, 0.1 part of beta glucan, 1 part of polyquaternium -51,1 part of Cer NP, 5 parts of hazel extract, the extraction of cynara scolymus leaf 1 part of object, 1 part of gorgonian extract, 1 part of orange peel extract hydrolyze European 1 part of Lee, 1 part of greater plantain seed extract, high mountain 1 part of plant extracts, 1 part of vapour bar jail, double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae -1 part of dicarboxylic ester, 0.6 part of triethanolamine, 1 part of didextrose base gallate, 0.1 part of essence.
The emulsifier is using stearine, sucrose stearate according to 1:1 mixing.
The grease is phytosterol isostearate, isohexadecane, tridecanol trimellitate are according to 2:1:1 is mixed It closes.
The preservative is Bis(hydroxymethyl)imidazolidinyl urea.The polyalcohol is glycerine, butanediol is according to 1:1 mixing.
The thickener is carbomer.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than being 3:The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating and carries It takes, 50 DEG C of bath temperature, ultrasonic time 2 hours is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.The gold fork Herba Dendrobii extract, angelica extract, Verbena officinalis extraction Object, Notogineng Extract, wild rose extract, radix paeoniae rubrathe medicament extract mixed proportion be 3:3:2:2:2:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 85 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, is put into oil phase pot, is heated with stirring to 75 DEG C, makes its dissolving complete, it is spare;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 5min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Embodiment 3
A kind of whitening emulsion of extract containing Magnolia binodii, by weight, specifically includes following components,
Component A:2 parts of cetostearyl alcohol olive oleate, 1.6 parts of the smooth olive oleate of sorb, 0.2 part of methyl hydroxybenzoate, hydroxyl 0.1 part of phenylpropyl alcohol ester, 0.3 part of Phenoxyethanol, 1 part of dimethyl silicone polymer, 0.5 part of phytosterol isostearate, tridecanol 2 parts of trimellitate, 3 parts of isopropyl myristate, 3 parts of caprylic/capric triglyceride, 2 parts of Nexbase 2004, Butyrospermum parkii fruit 1 part of fat, 1 part of isononyl isononanoate;
B component:10 parts of polyalcohol, 0.4 part of thickener, 0.1 part of allantoin, 68 parts of deionized water;
Component C:Magnolia binodii bud/1 part of flower extract, 0.2 part of tranexamic acid, 0.2 part of amino acid whitening agent, ubiquinone 0.01 Part, 0.06 part of Sodium Hyaluronate, 0.03 part of beta glucan, 0.01 part of polyquaternium -51,0.6 part of Cer NP, witch hazel 5 parts of extracting solution, 0.2 part of cynara scolymus leaf extract, 0.1 part of gorgonian extract, 0.1 part of orange peel extract hydrolyze European Lee 0.2 part, 0.1 part of greater plantain seed extract, 0.8 part of acrophyta extract, 0.02 part of vapour bar jail, double-diethoxy diethylene glycol (DEG) Hexamethylene Isosorbide-5-Nitrae -0.03 part of dicarboxylic ester, triethanolamine 0.02,0.01 part of didextrose base gallate, 0.02 part of essence.
The polyalcohol is glycerine, 1,3- propylene glycol is according to 2:1 mixing.
The thickener is the mixing of xanthans, carbomer.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than being 2.5:The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating and carries It takes, 45 DEG C of bath temperature, ultrasonic time 2 hours is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.The gold fork Herba Dendrobii extract, angelica extract, Verbena officinalis extraction Object, Notogineng Extract, wild rose extract, radix paeoniae rubrathe medicament extract mixed proportion be 3:3:2:2:2:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 82 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, is put into oil phase pot, is heated with stirring to 70 DEG C, makes its dissolving complete, it is spare;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 4min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Embodiment 4
A kind of whitening emulsion of extract containing Magnolia binodii, by weight, specifically includes following components,
Component A:3 parts of emulsifier, 10 parts of grease, 2.5 parts of preservative;
B component:10 parts of polyalcohol, 0.2 part of allantoin, 0.8 part of thickener, 50 parts of deionized water;
Component C:3 parts of Magnolia binodii extract, 0.5 part of tranexamic acid, 0.5 part of amino acid whitening agent, 0.2 part of ubiquinone, hyalomitome Sour 0.04 part of sodium, 0.06 part of beta glucan, 0.5 part of polyquaternium -51,0.4 part of Cer NP, hazel extract 2.5 Part, 0.45 part of cynara scolymus leaf extract, 0.6 part of gorgonian extract, 0.4 part of orange peel extract, European 0.5 part of Lee of hydrolysis, 0.6 part of greater plantain seed extract, 0.2 part of acrophyta extract, 0.4 part of vapour bar jail, double-diethoxy diethylene glycol (DEG) hexamethylene 1, 0.35 part of 4- dicarboxylic esters, 0.4 part of triethanolamine, 0.05 part of didextrose base gallate, 0.06 part of essence.
The emulsifier using cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, stearine according to 1:1:2 mixing.
The grease is phytosterol isostearate, isohexadecane, tridecanol trimellitate are according to 1:1:1 is mixed It closes.
The preservative is parahydroxyacet-ophenone, Phenoxyethanol is according to 2:1 mixing.
The polyalcohol is butanediol.The thickener is xanthans, carbomer is according to 1:2 mixing.
The Magnolia binodii extract is specially Magnolia binodii bud/flower extract, by ultrasonic wave extraction, specifically includes step Suddenly:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in presses volume by deionized water and ethyl alcohol Than being 2:The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating and carries It takes, 48 DEG C of bath temperature, ultrasonic time 1.5 hours is to get Magnolia binodii bud/flower extract.
The acrophyta extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubrathe medicament extract.The gold fork Herba Dendrobii extract, angelica extract, Verbena officinalis extraction Object, Notogineng Extract, wild rose extract, radix paeoniae rubrathe medicament extract mixed proportion be 4:1:3:2:1:1.
In addition, a kind of preparation method of the whitening emulsion the present invention also provides extract containing Magnolia binodii, specifically include with Lower step:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 82 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, is put into oil phase pot, is heated with stirring to 70 DEG C, makes its dissolving complete, it is spare;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and then step 2) is made In oil phase material sucking emulsifying kettle, homogeneous 3min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
Performance detection is carried out to whitening emulsion made from above-described embodiment, specific testing result is as shown in table 1 below.
The performance detection of 1 whitening emulsion of table
It is found that the whitening emulsion pH value of the present invention is 6.5-6.9 (standard 4.0-8.5), viscosity performance is analytical table 1 18659-20456 (standard 10000-30000cp), relative density are 0.985-1.015 (standard 0.98-1.02), in addition, Its appearance, odor type, cold-resistant and heat resistance are also qualified, and centrifugation is without exception.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention Any modification, equivalent replacement or improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of whitening emulsion of extract containing Magnolia binodii, which is characterized in that by weight, following components is specifically included,
Component A:1-5 parts of emulsifier, 5-15 parts of grease, 0.1-5 parts of preservative;
B component:5-20 parts of polyalcohol, 0.01-0.5 parts of allantoin, 0.1-2 parts of thickener, 40-65 parts of deionized water;
Component C:0.01-5 parts of Magnolia binodii extract, 0.01-1 parts of tranexamic acid, 0.1-1 parts of amino acid whitening agent, ubiquinone 0.01- 0.5 part, 0.01-0.1 parts of Sodium Hyaluronate, 0.01-0.1 parts of beta glucan, -51 0.01-1 parts of polyquaternium, Cer NP 0.01-1 parts, 0.5-5 parts of hazel extract, 0.01-1 parts of cynara scolymus leaf extract, 0.01-1 parts of gorgonian extract, citrus fruit 0.01-1 parts of bark extract hydrolyzes European 0.01-1 parts of Lee, 0.01-1 parts of greater plantain seed extract, acrophyta extract 0.01-1 parts, 0.01-1 parts of vapour bar jail, double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae -0.01-1 parts of dicarboxylic ester, triethanolamine 0-0.6 parts, 0.001-1 parts of didextrose base gallate, 0.01-0.1 parts of essence.
2. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the emulsifier is adopted With cetostearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, stearine, sucrose stearate, One or more mixing in PEG-40 stearates, ceteareth -20.
3. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the grease is poly- It is dimethyl siloxane, phytosterol isostearate, isohexadecane, tridecanol trimellitate, isopropyl myristate, pungent Acid/Triglyceride DDD, Nexbase 2004, Butyrospermum parkii fruit fat, cyclopentasiloxane, rose hip oil, isononyl isononanoate one Kind or a variety of mixing.
4. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the preservative is 1,2- hexylene glycols, parahydroxyacet-ophenone, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, second One or more mixing in base hexyl glycerine, methyl hydroxybenzoate or Nipasol.
5. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the polyalcohol is One or more mixing in glycerine, butanediol, 1,3- propylene glycol.
6. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the thickener is One or more mixing in hydroxyethyl cellulose, xanthans, carbomer, acrylic acid (ester) analog copolymer sodium.
7. the whitening emulsion of a kind of extract containing Magnolia binodii according to claim 1, which is characterized in that the Magnolia binodii carries It is specially Magnolia binodii bud/flower extract to take object, by ultrasonic wave extraction, specifically includes step:
First Magnolia binodii bud/flower is ground, according to 1:30 solid-liquid ratio is added in by deionized water and ethyl alcohol (1-3):The mixed liquor of 1 composition, then puts it into the container that inner wall is ceramic material, carries out ultrasound bath heating and carries It takes, 45-50 DEG C of bath temperature, ultrasonic time 1-2 hours is to get Magnolia binodii bud/flower extract.
A kind of 8. whitening emulsion of extract containing Magnolia binodii according to claim 1, which is characterized in that the acrophyta Extract includes gold fork Herba Dendrobii extract, angelica extract, Herba Verbenae, Notogineng Extract, wild rose extract, the radix paeoniae rubrathe The mixing of medicament extract.
A kind of 9. whitening emulsion of extract containing Magnolia binodii according to claim 8, which is characterized in that the gold fork stem of noble dendrobium Extract, angelica extract, Herba Verbenae, Notogineng Extract, wild rose extract, radix paeoniae rubrathe medicament extract mixed proportion It is 3:3:2:2:2:1.
10. the preparation method of the whitening emulsion of the extract containing Magnolia binodii, feature exist described in a kind of any one of claim 1-9 In specifically including following steps:
1) component A of formula ratio is weighed, puts into water phase pot, is heated with stirring to 80-85 DEG C, makes its dissolving complete, it is spare;
2) B component of formula ratio is weighed, puts into oil phase pot, is heated with stirring to 65-75 DEG C, makes its dissolving complete, it is spare;
3) in the water phase material sucking emulsifying kettle obtained step 1), stirring cools to 70 DEG C, and step 2) then is made oil phase In material sucking emulsifying kettle, homogeneous 1-5min continues stirring cooling;
4) when temperature drops to 45 DEG C, component C is added in, is stirred evenly;
5) when temperature is dropped to below 40 DEG C, filtering and discharging.
CN201810249927.7A 2018-03-26 2018-03-26 A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof Pending CN108186503A (en)

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CN111437231A (en) * 2020-04-18 2020-07-24 北温草生物科技(上海)有限公司 Chinese herbal medicine composition for resisting wrinkles and resisting aging
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CN117224448A (en) * 2023-11-01 2023-12-15 广州品域美妆创新科技有限公司 Anti-wrinkle and soothing composition as well as preparation method and application thereof

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CN110812265A (en) * 2018-08-10 2020-02-21 重庆戴贺李生物科技有限公司 Soothing, repairing and moisturizing essence emulsion
CN111714390A (en) * 2019-03-19 2020-09-29 西安博鸿生物技术有限公司 Whitening essence milk and preparation method thereof
CN109966231A (en) * 2019-04-11 2019-07-05 冯江 A kind of bright face skin beautifying cream and preparation method thereof
CN110974726A (en) * 2019-12-31 2020-04-10 福建省梦娇兰日用化学品有限公司 Infant skin cream based on ultrasonic assistance
CN111437231A (en) * 2020-04-18 2020-07-24 北温草生物科技(上海)有限公司 Chinese herbal medicine composition for resisting wrinkles and resisting aging
CN111991306A (en) * 2020-09-29 2020-11-27 珠海远大美业生物科技有限公司 Anti-aging repairing pure liquid, preparation method and application thereof
CN117224448A (en) * 2023-11-01 2023-12-15 广州品域美妆创新科技有限公司 Anti-wrinkle and soothing composition as well as preparation method and application thereof
CN117224448B (en) * 2023-11-01 2024-05-14 广州品域美妆创新科技有限公司 Anti-wrinkle and soothing composition as well as preparation method and application thereof

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Application publication date: 20180622