CN108157352A - Multiple organ one perfusion equipment - Google Patents

Abstract

The present invention relates to a kind of multiple organ one perfusion equipments, and including mainframe, control system and multiple pipeline circulatory systems, multiple pipeline circulatory systems communicate to connect control device respectively, and each pipeline circulatory system includes：Centrifugal blood pump is communicatively coupled to control system；Oxygenator, the arrival end pipeline of oxygenator are connected to the port of export of centrifugal blood pump；Filter, the arrival end pipeline of filter are connected to the port of export of oxygenator；Multiple organs place containers, and each organ places the arrival end of container, and pipeline is connected to the port of export of filter respectively, and each organ places the port of export of container, and pipeline is connected to the arrival end of centrifugal blood pump respectively；Organ, which is placed, is equipped with flow control valve between container and filter.Above-mentioned multiple organ one perfusion equipment since control system can control multiple pipeline circulatory systems simultaneously, can be in different working condition according to devices such as the centrifugal blood pumps needed to control in the different pipeline circulatory systems of different isolated organs.

Description

Multi-organ perfusion equipment

technical field

The invention relates to the field of organ preservation devices, in particular to a multi-organ integrated filling device.

Background technique

Organ transplantation is a procedure in which a healthy organ is transplanted into another human body to rapidly restore its function, with the purpose of replacing the corresponding organ of the recipient that has lost function due to a fatal disease. Commonly used transplant organs include heart, liver, kidney, lung, cornea, pancreas and small intestine. There are many factors affecting the function of grafts after operation, and organ preservation is one of the three pillars of organ transplantation. An ideal preservation method can provide a suitable microenvironment for isolated organs and maximize the preservation time of organs. Research hotspots in the field of transplantation.

At present, low-temperature static storage is more common. Low-temperature static storage reduces energy consumption of organs through low temperature, thereby prolonging the preservation time of organs. It has the advantages of simplicity, safety, and low price. However, low-temperature static storage may also cause tissue cell damage and organ ischemia-reperfusion. damage etc. Compared with low-temperature static preservation, mechanical perfusion is a new type of organ preservation and transport. After the organ is harvested, the mechanical perfusion system of the organ is connected to the blood vessels of the organ through the pipeline, and the perfusate continues to perfuse the isolated organ during the organ preservation and transport stages, and at the same time supplies the isolated organ with oxygen, nutrients, etc. Thrombosis or related foreign bodies are used to maintain the patency of the blood vessels of the organ, thereby improving the success rate of organ transplantation and increasing the utilization rate of donor-side organs. However, the current organ mechanical filling system can only provide a single filling method for organs, and cannot meet the different preservation needs of different organs.

Contents of the invention

Based on this, it is necessary to provide a multi-organ integrated filling device that can preserve different organs in view of the problem that organ mechanical perfusion systems cannot meet the different preservation requirements of different organs.

A multi-organ integrated perfusion device, including a main frame, a control system installed on the main frame, and a plurality of pipeline circulation systems installed on the main frame, and the plurality of pipeline circulation systems are connected to the system through communication. system, each of said pipeline circulation systems comprising:

a centrifugal blood pump installed on the main frame, and the centrifugal blood pump is connected to the control system by communication;

An oxygenator installed on the main frame, the inlet port of the oxygenator is connected to the outlet port of the centrifugal blood pump;

A filter is installed on the main frame, and the inlet port of the filter is connected to the outlet port of the oxygenator; and

A plurality of organ storage containers are installed on the main frame, the inlet port of each organ storage container is connected to the outlet port of the filter respectively, and the outlet port of each organ storage container is connected to the filter port respectively. The inlet end of the centrifugal blood pump; a flow control valve is arranged between the organ placement container and the filter.

In the above-mentioned multi-organ integrated perfusion equipment, the centrifugal blood pump, under the control of the control system, sequentially transports the perfusate to the oxygenator that provides oxygen and the filter that filters the perfusate, and finally reaches the organ placement container respectively, so that the perfusate placed in the organ Place the isolated organ in the container for perfusion, supply oxygen and nutrients to the organ, and remove thrombus or related foreign matter in the isolated organ at the same time to maintain the patency of the blood vessels of the isolated organ and improve the success rate of transplantation. Moreover, since the control system can control multiple pipeline circulation systems at the same time, it can control devices such as centrifugal blood pumps in different pipeline circulation systems to be in different working states according to the needs of different isolated organs.

In one of the embodiments, the pipeline circulation system includes a pressure sensor communicatively connected with the control system, and the pressure sensor is installed on the pipeline connecting the flow control valve and the organ placement container.

In one of the embodiments, the pipeline circulation system includes a flow sensor communicated with the control system, and the flow sensor is installed on the pipeline connecting the flow control valve and the organ placement container.

In one of the embodiments, the pipeline circulation system further includes a temperature control device communicatively connected with the control system, the temperature control device includes a circulating water tank, and the circulating water tank is provided with a water outlet and a return port. The oxygenator includes a water inlet and a water outlet, the water outlet is connected to the water inlet pipe, and the water outlet is connected to the return pipe.

In one of the embodiments, the multi-organ perfusion equipment further includes an oxygen supply device, and the oxygen supply device is placed on the main frame.

In one of the embodiments, the multi-organ integrated perfusion device further includes a blood gas analysis device, and the blood gas analysis device is movably placed on the main frame.

In one of the embodiments, the multi-organ integrated perfusion equipment further includes an image acquisition device, the image acquisition device includes a lifting bracket and a camera, the installation bracket is detachably installed on the main frame, and the camera can It is rotatably installed on the lifting bracket.

In one embodiment, the control system includes a first control device and a second control device, the first control device communicates with the centrifugal blood pump to control the working state of the centrifugal blood pump, and the first control device communicates with the centrifugal blood pump to control the working state of the centrifugal blood pump. The second control device is connected in communication with the first controller.

In one of the embodiments, the main frame includes an installation frame and a main box, the installation frame includes a first storage space and a second storage space, the main box is located in the first storage space, and the organ storage container Located in the second receiving space, the first control device is located in the main box, and the second control device is installed on an end of the installation frame away from the main box.

In one of the embodiments, the second control device includes a display screen, and the display screen is movably installed on the main frame.

Description of drawings

Fig. 1 is the front view of the multi-organ integrated perfusion device of the embodiment;

Fig. 2 is a control schematic diagram of the multi-organ integrated perfusion device shown in Fig. 1

Fig. 3 is a rear view of the multi-organ integrated perfusion device shown in Fig. 1;

Fig. 4 is a side view of the multi-organ integrated perfusion device shown in Fig. 1;

Fig. 5 is a top view of the multi-organ integrated perfusion device shown in Fig. 1 .

Detailed ways

In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

It should be noted that when an element is referred to as being “fixed” to another element, it can be directly on the other element or there can also be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and similar expressions are used herein for purposes of illustration only.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

As shown in FIGS. 1 to 3 , a multi-organ integrated perfusion device 100 according to this preferred embodiment includes a main frame 20 , a control system 40 installed on the main frame 20 and a plurality of pipeline circuits installed on the main frame 20 . system, multiple pipeline circulation systems are respectively connected to the control system 40 through communication, and the control system 40 can respectively control multiple pipeline circulation systems to simultaneously perfuse multiple groups of isolated organs with perfusion fluid (such as blood).

Specifically, each pipeline circulation system includes a centrifugal blood pump 61 , an oxygenator 62 , a filter 64 and a plurality of organ placement containers 65 respectively installed on the main frame 20 .

Wherein, the centrifugal blood pump 61 is communicatively connected to the control system 40 , and the centrifugal blood pump 61 delivers the perfusate to the oxygenator 62 under the control of the control system 40 . The inlet port of the oxygenator 62 is connected to the outlet port of the centrifugal blood pump 61 , and the perfusate is mixed with oxygen in the oxygenator 62 . The inlet port of the filter 64 is connected to the outlet port of the oxygenator 62 through a pipe to filter the perfusate output from the oxygenator 62 to remove air bubbles and other impurities in the perfusate. The inlet end of each organ placement container 65 is connected to the outlet end of the filter 64 through pipelines, and the outlet end of each organ placement container 65 is connected to the inlet end of the centrifugal blood pump 61 through pipelines. In this way, the perfusate output from the filter 64 enters the organ placement container 65 to perfuse the isolated organs in the organ placement container 65 . The perfusate output from the organ returns to the centrifugal blood pump 61 for the next cycle. A flow control valve 66 is provided between the organ placement container 65 and the filter 64 to control the flow of perfusate flowing into each organ placement container 65 according to the different needs of each isolated organ.

Under the control of the control system 40 in the multi-organ perfusion device 100 described above, the centrifugal blood pump 61 sequentially transports the perfusate to the oxygenator 62 for providing oxygen and the filter 64 for filtering the perfusate, and finally reaches the organ storage container 65 respectively. , to perfuse the isolated organ placed in the organ placement container 65, supply oxygen and nutrients to the organ, and remove thrombus or related foreign matter in the isolated organ at the same time to maintain the patency of the blood vessels of the isolated organ and improve the success rate of transplantation . Moreover, since the control system 40 can control multiple pipeline circulation systems at the same time, it can control devices such as the centrifugal blood pump 61 in different pipeline circulation systems to be in different working states according to the needs of different isolated organs.

Please continue to refer to FIGS. 1 to 3. Specifically, a plurality of isolated organs can be respectively placed in an organ placement container 65, and the shape of each organ placement container 65 matches the shape of the corresponding isolated organ, thereby having a higher specificity. The pipeline connected to the outlet end of the filter 64 is divided into a plurality of branches, and each branch passes through the top of the organ placement container 65 and enters into the corresponding blood vessel of the isolated organ. The pipeline connected to the inlet end of the centrifugal blood pump 61 is also divided into multiple branches, and the multiple branches respectively pass through the bottom of the organ placement container 65 to access corresponding blood vessels of the isolated organ. In this way, the perfusate output from the filter 64 enters the organ placement container 65 through a plurality of branch pipes to perfuse the isolated organ, and the perfusate flowing out of the isolated organ flows into the centrifuged blood after converging through a plurality of branch pipes. In the pump 61, the perfusion of the isolated organ and the recycling of the perfusate are completed. As shown in Figure 5, in this embodiment, a pipeline circulation system includes four organ placement containers 65, and the four organ placement containers 65 are arranged side by side along the length direction of the main frame 20, and the four organs can be respectively placed in corresponding The organ is placed in the container 65.

The flow control valve 66 is a manual regulating valve or an electric regulating valve communicatively connected with the control system 40 . During the perfusion process, the perfusate can be manually adjusted in real time, or the control system 40 can be used for automatic flow regulation.

In one embodiment, the organ placement container 65 is also provided with a secretion collection interface (not shown in the figure), when the organ placement container 65 is placed with isolated organs that need to recover secretions, it can be connected through the secretion collection interface. Recover tubing for collection of ex vivo secretions.

In one embodiment, the pipeline connecting the organ placement container 65 and the inlet port of the centrifugal blood pump 61 is also provided with a medicine injection port (not shown in the figure), so as to add medicine required for perfusion. It can be understood that the location of the drug injection port is not limited thereto, and it can also be provided on the pipeline connecting the outlet end of the filter 64 and the organ placement container 65 .

Please continue to refer to FIGS. 1 and 5 , the pipeline circulation system includes a pressure sensor 67 communicatively connected with the control system 40 , the pressure sensor 67 is installed in the pipeline connecting the flow control valve 66 and the organ placement container 65 , and is used to detect the connection flow control valve 66 The perfusion pressure of the perfusate in the pipeline with the organ placement container 65, and feed back the perfusion pressure value to the control system 40, so that the control system 40 can obtain the perfusion pressure in real time, and control the centrifugal blood pump 61 and flow control according to the perfusion pressure The working state of the valve 66.

The pipeline circulation system also includes a flow sensor 68 communicatively connected with the control system 40. The flow sensor 68 is installed in the pipeline connecting the flow control valve 66 and the organ placement container 65, and is used to detect the flow rate of the pipeline connecting the flow control valve 66 and the organ placement container 65. The flow rate of the perfusate in unit time, and the flow rate is fed back to the control system 40, so that the control system 40 can obtain the flow rate of the perfusate in real time, and control the centrifugal blood pump 61 and the flow control valve 66 according to the flow rate working status.

The pipeline circulation system also includes a temperature control device 63 communicatively connected with the control system 40 , the temperature control device 63 can adjust the temperature of the perfusate passing through the oxygenator 62 under the control of the control system 40 . Specifically, the temperature control device 63 includes a circulating water tank, which is provided with a water outlet and a return port, and the oxygenator 62 includes a heat exchange structure (not shown) with a water inlet and a water outlet. The water outlet is connected to the water inlet pipe, and the water outlet is connected to the return pipe. In this way, the circulating water in the circulating water tank flows out through the water outlet and enters the oxygenator 62 through the water inlet, where it exchanges heat with the perfusate To adjust the temperature of the perfusate, the circulating water after the heat exchange flows out from the drain port, and then flows into the circulating water tank through the return port. Specifically, in this embodiment, the temperature range of the heat exchange liquid in the circulating water tank is 0-40° C., so that the perfusion temperature can be adjusted within this range according to different needs of isolated organs.

In one embodiment, the multi-organ perfusion device 100 further includes an oxygen supply device 69 filled with oxygen, the oxygen supply device 69 is placed on the main frame 20, and is used to connect the oxygenator 62 to provide the oxygenator 62 with oxygen at different concentrations. oxygen. Specifically, in this embodiment, the oxygen supply device 69 includes three oxygen cylinders with different oxygen concentrations, so that different oxygen cylinders can be selected to provide oxygen for the perfusate according to the actual perfusion requirements of the isolated organ.

In one embodiment, the multi-organ integrated perfusion device 100 further includes a blood gas analysis device 80 , which is removably placed on the main frame 20 . The operator can take the blood gas analysis device 80 at any time to detect the pH, partial pressure of carbon dioxide, partial pressure of oxygen and other related indicators of the isolated organ located in the organ storage container 65, so as to monitor the real-time status of the isolated organ. Specifically, in this embodiment, the main frame 20 is provided with a drawer structure, and the blood gas analysis device 80 is stored in the drawer structure for easy access.

In an embodiment, as shown in FIG. 1 and FIG. 4 , the multi-organ integrated perfusion device 100 further includes an image acquisition device 90 for acquiring images or videos. The image acquisition device 90 includes a lifting bracket 94 and a camera 92. The lifting bracket 94 is installed on the main frame 20, and the camera 92 is rotatably installed on the lifting bracket 94 so as to adjust the shooting angle of the camera, thereby clearly and accurately recording the isolated organs in real time. Perfused continuous condition.

Please continue to refer to FIGS. 1 to 3. The control system 40 includes a first control device 42 and a second control device 44. The first control device 42 communicates with the centrifugal blood pump 61, flow control valve 66 and other devices to control the centrifugal blood pump 61. , flow control valve 66 and other devices, and connect with pressure sensor 67, flow sensor 68 and other devices to obtain the pressure value and flow value of the perfusate. The second control device 44 is communicatively connected with the first control device 42, and the first control device 42 can send data such as pressure value and flow value obtained by it to the second control device 44, and the second control device 44 can send control according to the data. The signal is sent to the first control device 42, and the first control device 42 can control the working status of the centrifugal blood pump 61, flow control valve 66 and other devices according to the control signal, so as to adjust the perfusion situation in real time according to the pressure value and flow value of the perfusate , to meet the different needs of isolated organs in different states.

The main frame 20 includes an installation frame 22 and a main box 24. The installation frame 22 includes a first storage space and a second storage space above the first storage space. The main box 24 is located in the first storage space, and the organ placement container 65 is located in the second storage space. space. The first control device 42 is located in the main box 24 to isolate from the external environment and avoid being damaged or polluted. The second control device 44 is installed on the installation frame 22 away from the end of the main box 24, so that the operator can easily carry out the second control device 44. operate. In this embodiment, the installation frame 22 is further provided with rotatable moving wheels 222 , so as to facilitate the movement of the multi-organ integration perfusion device 100 .

Further, the second control device 44 also includes a display screen 442 , and the display screen 442 is movably installed on the main frame 20 . In this way, the data such as pressure value and flow value obtained by the second control device 44 through the first control device 42 can be displayed on the display screen 442, and the operator can directly obtain the working status of the multi-organ integrated perfusion device 100 through the display screen 442, to adjust it in time. Specifically, in this embodiment, the second control device 44 includes two display screens 442 , and the two display screens 442 are movably installed at both ends of the main frame 20 in the length direction through mounting brackets. The two display screens 442 can display the same data at the same time, and can also display the data of different organ storage containers 65 respectively, and the positions of the two display screens can be adjusted through the mounting brackets respectively, so they have high flexibility and operability.

The multi-organ integrated perfusion device 100 mentioned above can remove thrombus and related foreign matter in the isolated organs located in the organ storage container 65 through the pipeline circulation system, realize simultaneous perfusion of multiple organs and independently detect each organ. Moreover, the control system 40 can be connected to multiple pipeline circulation systems, so multiple groups of isolated organs can be perfused simultaneously to meet the different needs of different organs and improve the success rate of organ transplantation. Moreover, the control system 40 can perform real-time display and timely feedback on the working conditions of the pipeline circulation system, and has excellent flexibility and maneuverability. Moreover, the installed temperature control device 63, oxygen supply device 69, blood gas analysis device 80, image acquisition device 90 and other structures can further meet the different requirements of the isolated organs, and monitor the isolated organs in real time to ensure that the blood vessels of the isolated organs unobstructed.

The technical features of the above-mentioned embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, should be considered as within the scope of this specification.

The above-mentioned embodiments only express several implementation modes of the present invention, and the descriptions thereof are relatively specific and detailed, but should not be construed as limiting the patent scope of the invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (10)

1. A multi-organ integrated perfusion device, characterized in that it includes a main frame, a control system installed on the main frame, and a plurality of pipeline circulation systems installed on the main frame, and a plurality of pipeline circulation systems The control systems are respectively connected by communication, and each pipeline circulation system includes: a centrifugal blood pump installed on the main frame, and the centrifugal blood pump is connected to the control system by communication; An oxygenator installed on the main frame, the inlet port of the oxygenator is connected to the outlet port of the centrifugal blood pump; A filter is installed on the main frame, and the inlet port of the filter is connected to the outlet port of the oxygenator; and A plurality of organ storage containers are installed on the main frame, the inlet port of each organ storage container is connected to the outlet port of the filter respectively, and the outlet port of each organ storage container is connected to the filter port respectively. The inlet end of the centrifugal blood pump; a flow control valve is arranged between the organ placement container and the filter. 2. The multi-organ integrated perfusion device according to claim 1, wherein the pipeline circulation system includes a pressure sensor connected in communication with the control system, and the pressure sensor is installed on the connection between the flow control valve and the control system. The conduit of the organ housing container. 3. The multi-organ integrated perfusion device according to claim 1, wherein the pipeline circulation system includes a flow sensor connected in communication with the control system, and the flow sensor is installed on the connection between the flow control valve and the control system. The conduit of the organ housing container. 4. The multi-organ integrated perfusion equipment according to claim 1, characterized in that, the pipeline circulation system further comprises a temperature control device communicatively connected with the control system, the temperature control device comprises a circulating water tank, the The circulating water tank is provided with a water outlet and a return port, and the oxygenator includes a water inlet and a water discharge port, the water outlet is connected to the water inlet pipe, and the water discharge port is connected to the return pipe. 5. The multi-organ integration perfusion device according to claim 1, characterized in that, the multi-organ integration perfusion device further comprises an oxygen supply device, and the oxygen supply device is placed on the main frame. 6. The multi-organ integrated perfusion device according to claim 1, characterized in that the multi-organ integrated perfusion device further comprises a blood gas analysis device, and the blood gas analysis device is movably placed on the main frame. 7. The multi-organ integrated perfusion equipment according to claim 1, characterized in that, the multi-organ integrated perfusion equipment also includes an image acquisition device, the image acquisition device includes a lifting bracket and a camera, and the installation bracket is detachable Installed on the main frame, the camera is rotatably installed on the lifting bracket. 8. The multi-organ integrated perfusion device according to any one of claims 1-7, wherein the control system includes a first control device and a second control device, and the first control device and the centrifuged blood The pump is connected in communication to control the working state of the centrifugal blood pump, and the second control device is connected in communication with the first controller. 9. The multi-organ integrated perfusion device according to claim 8, characterized in that, the main frame includes an installation frame and a main box, the installation frame includes a first storage space and a second storage space, and the main box is located at The first storage space, the organ storage container is located in the second storage space, the first control device is located in the main box, and the second control device is installed on the end of the installation frame away from the main box . 10. The perfusion equipment for multiple organs according to claim 9, wherein the second control device comprises a display screen, and the display screen is movably installed on the main frame.