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CN108144199A - Device, method and system are motivated by ultrasound - Google Patents

Device, method and system are motivated by ultrasound Download PDF

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Publication number
CN108144199A
CN108144199A CN201711401737.4A CN201711401737A CN108144199A CN 108144199 A CN108144199 A CN 108144199A CN 201711401737 A CN201711401737 A CN 201711401737A CN 108144199 A CN108144199 A CN 108144199A
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ultrasonic
signal
excitation
waveform
parameters
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邱维宝
孙武
周娟
言文斌
李锦成
郑海荣
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Shenzhen Institute of Advanced Technology of CAS
University of Chinese Academy of Sciences
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Shenzhen Institute of Advanced Technology of CAS
University of Chinese Academy of Sciences
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Priority to CN201711401737.4A priority Critical patent/CN108144199A/en
Priority to PCT/CN2017/120162 priority patent/WO2019119519A1/en
Publication of CN108144199A publication Critical patent/CN108144199A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88Sonar systems specially adapted for specific applications
    • G01S15/89Sonar systems specially adapted for specific applications for mapping or imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0004Applications of ultrasound therapy
    • A61N2007/0021Neural system treatment
    • A61N2007/0026Stimulation of nerve tissue

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  • Engineering & Computer Science (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Remote Sensing (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Surgical Instruments (AREA)

Abstract

The embodiment of the present invention provides a kind of ultrasonic action device, method and system.Device is motivated by ultrasound and includes waveform generator, power amplifier and ultrasound transducer array.After waveform generator is used for the ultrasonic action parameter for obtaining each channel, the waveform stimulus signal of each channel is generated according to ultrasonic action parameter.Power amplifier is electrically connected with waveform generator, for waveform stimulus signal to be carried out power amplification, is generated high-voltage driven signal and is inputed to ultrasound transducer array.Ultrasound transducer array is used to generate ultrasonic wave in corresponding array element according to high-voltage driven signal, and ultrasound transducer array includes multiple array elements, and each array element corresponds to a channel.Thus, it is possible to give full play to the performance of ultrasonic transducer, more preferably ultrasonic mechanics effect and fuel factor are obtained.

Description

超声激励装置、方法及系统Ultrasonic excitation device, method and system

技术领域technical field

本发明涉及医疗器械技术领域,具体而言,涉及一种超声激励装置、方法及系统。The present invention relates to the technical field of medical devices, in particular to an ultrasonic excitation device, method and system.

背景技术Background technique

目前传统的神经调控方法一般采用单一频率单一波形激励,例如正弦波或者方波激励,但是单一频率的激励信号,不能充分发挥超声换能器的性能。并且,当前的设备硬件上多采用类似于直接数字式频率合成器的方法来生成激励信号,这种方法灵活性较差。At present, traditional neuromodulation methods generally use a single frequency and a single waveform excitation, such as sine wave or square wave excitation, but the excitation signal of a single frequency cannot give full play to the performance of the ultrasonic transducer. Moreover, current device hardware mostly adopts a method similar to a direct digital frequency synthesizer to generate an excitation signal, and this method is less flexible.

发明内容Contents of the invention

为了克服现有技术中的上述不足,本发明的目的在于提供一种超声激励装置、方法及系统,可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号,从而可以充分发挥超声换能器的性能,获得更佳的超声力学效应以及热效应。In order to overcome the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide an ultrasonic excitation device, method and system, which can flexibly configure the ultrasonic excitation parameters of each channel to generate excitation signals of arbitrary waveforms, so that the ultrasonic energy can be fully utilized. The performance of the instrument can obtain better ultrasonic mechanical effect and thermal effect.

为了实现上述目的,本发明较佳实施例采用的技术方案如下:In order to achieve the above object, the technical scheme adopted in the preferred embodiment of the present invention is as follows:

本发明较佳实施例提供一种超声激励装置,所述超声激励装置包括波形发生器、功率放大器以及超声换能器阵列。A preferred embodiment of the present invention provides an ultrasonic excitation device, which includes a waveform generator, a power amplifier, and an array of ultrasonic transducers.

所述波形发生器用于获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号。The waveform generator is used to generate the waveform excitation signal of each channel according to the ultrasonic excitation parameters after obtaining the ultrasonic excitation parameters of each channel.

所述功率放大器与所述波形发生器电性连接,用于将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列。The power amplifier is electrically connected to the waveform generator, and is used to amplify the power of the waveform excitation signal to generate a high-voltage driving signal and input it to the ultrasonic transducer array.

所述超声换能器阵列用于根据所述高压驱动信号在相应的阵元上产生超声波,其中,所述超声换能器阵列包括有多个阵元,每个阵元对应一个通道。The ultrasonic transducer array is used to generate ultrasonic waves on corresponding array elements according to the high-voltage driving signal, wherein the ultrasonic transducer array includes a plurality of array elements, and each array element corresponds to a channel.

在本发明较佳实施例中,其中,所述超声激励参数包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率。In a preferred embodiment of the present invention, the ultrasonic excitation parameters include at least one of waveform shape, signal frequency, signal amplitude, and focusing parameters, and the signal frequency includes single frequency waveform frequency or complex frequency waveform frequency.

在本发明较佳实施例中,上述波形发生器包括通讯接口、信号处理器以及数模转换器阵列。In a preferred embodiment of the present invention, the waveform generator includes a communication interface, a signal processor, and a digital-to-analog converter array.

所述信号处理器分别与所述通讯接口和所述数模转换器阵列电性连接,用于控制所述通讯接口接收每个通道的超声激励参数,并根据所述超声激励参数生成对应的通道的波形激励信号,再将所述波形激励信号写入所述数模转换器阵列中对应的数模转换器中,以通过所述数模转换器将所述波形激励信号转换为模拟信号并输出至所述功率放大器。The signal processor is electrically connected to the communication interface and the digital-to-analog converter array respectively, and is used to control the communication interface to receive ultrasonic excitation parameters of each channel, and generate corresponding channels according to the ultrasonic excitation parameters The waveform excitation signal, and then write the waveform excitation signal into the corresponding digital-to-analog converter in the digital-to-analog converter array, so that the waveform excitation signal is converted into an analog signal by the digital-to-analog converter and output to the power amplifier.

在本发明较佳实施例中,上述信号处理器还用于控制所述通讯接口接收控制参数,并根据所述控制参数控制所述数模转换器阵列以及所述功率放大器的工作状态,其中,所述控制参数包括功率放大倍数、脉冲重复频率、发射控制参数、回波接收控制参数中的至少一种或者多种组合。In a preferred embodiment of the present invention, the above-mentioned signal processor is also used to control the communication interface to receive control parameters, and control the working states of the digital-to-analog converter array and the power amplifier according to the control parameters, wherein, The control parameters include at least one or a combination of multiples of power amplification, pulse repetition frequency, transmission control parameters, and echo reception control parameters.

在本发明较佳实施例中,上述信号处理器包括现场可编程门阵列或者数字信号处理器。In a preferred embodiment of the present invention, the signal processor includes a field programmable gate array or a digital signal processor.

在本发明较佳实施例中,上述信号处理器包括:In a preferred embodiment of the present invention, the above-mentioned signal processor includes:

用于控制所述通讯接口的通讯处理单元;a communication processing unit for controlling the communication interface;

用于根据所述超声激励参数生成各个通道的波形激励信号,并将所述波形激励信号写入所述数模转换器阵列的逻辑处理单元;以及A logic processing unit for generating a waveform excitation signal of each channel according to the ultrasonic excitation parameters, and writing the waveform excitation signal into the digital-to-analog converter array; and

用于根据聚焦参数将产生的波形激励信号进行相位延时的波束合成单元。A beamforming unit for phase-delaying the generated waveform excitation signal according to the focusing parameters.

在本发明较佳实施例中,上述超声激励装置还包括回波采集模块和回波成像模块;In a preferred embodiment of the present invention, the above-mentioned ultrasonic excitation device further includes an echo acquisition module and an echo imaging module;

所述回波采集模块,用于在采集到经由所述超声换能器阵列探测到的超声回波信号后进行信号处理,并将处理后的超声回波信号转换为数字信号;The echo collection module is configured to perform signal processing after collecting the ultrasonic echo signals detected by the ultrasonic transducer array, and convert the processed ultrasonic echo signals into digital signals;

所述回波成像模块与所述回波采集模块电性连接,用于根据波束合成参数对所述数字信号进行信号处理,得到对应的超声回波数据,并将所述超声回波数据传输给计算机设备进行超声成像。The echo imaging module is electrically connected to the echo acquisition module, and is used to perform signal processing on the digital signal according to beamforming parameters to obtain corresponding ultrasonic echo data, and transmit the ultrasonic echo data to Computer equipment for ultrasound imaging.

在本发明较佳实施例中,上述回波采集模块包括超声模拟前端放大单元和模拟信号采集单元;In a preferred embodiment of the present invention, the above-mentioned echo acquisition module includes an ultrasonic analog front-end amplification unit and an analog signal acquisition unit;

所述超声模拟前端放大单元与所述模拟信号采集单元电性连接,用于对所述超声回波信号经过前置放大、滤波、压控放大后发送给所述模拟信号采集单元进行模数转换后,输出数字信号。The ultrasonic analog front-end amplification unit is electrically connected to the analog signal acquisition unit, and is used to send the ultrasonic echo signal to the analog signal acquisition unit for analog-to-digital conversion after pre-amplification, filtering, and voltage-controlled amplification After that, a digital signal is output.

在本发明较佳实施例中,上述超声换能器阵列包括激励探头和成像探头;In a preferred embodiment of the present invention, the above-mentioned ultrasonic transducer array includes an excitation probe and an imaging probe;

所述激励探头用于根据高压驱动信号产生超声波;The excitation probe is used to generate ultrasonic waves according to the high-voltage driving signal;

所述成像探头用于在探测超声回波以用于成像监测。The imaging probe is used to detect ultrasonic echoes for imaging monitoring.

本发明较佳实施例还提供一种超声激励方法,应用于上述的超声激励装置,所述方法包括:A preferred embodiment of the present invention also provides an ultrasonic excitation method, which is applied to the above-mentioned ultrasonic excitation device, and the method includes:

所述波形发生器获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号,其中,所述超声激励参数包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率;After the waveform generator obtains the ultrasonic excitation parameters of each channel, it generates the waveform excitation signal of each channel according to the ultrasonic excitation parameters, wherein the ultrasonic excitation parameters include waveform shape, signal frequency, signal amplitude, and focusing parameters. At least one of, the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency;

所述功率放大器将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列;The power amplifier amplifies the power of the waveform excitation signal to generate a high-voltage driving signal and input it to the ultrasonic transducer array;

所述超声换能器阵列根据所述高压驱动信号在相应的阵元上产生超声波,其中,所述超声换能器阵列包括有多个阵元,每个阵元对应一个通道。The ultrasonic transducer array generates ultrasonic waves on corresponding array elements according to the high-voltage driving signal, wherein the ultrasonic transducer array includes a plurality of array elements, and each array element corresponds to a channel.

本发明较佳实施例还提供一种超声激励系统,所述超声激励系统包括计算机设备以及上述的超声激励装置;A preferred embodiment of the present invention also provides an ultrasonic excitation system, which includes computer equipment and the above-mentioned ultrasonic excitation device;

所述计算机设备与所述超声激励装置通信连接,用于向所述超声激励装置发送各个通道的超声激励参数;The computer equipment is communicatively connected with the ultrasonic excitation device, and is used to send ultrasonic excitation parameters of each channel to the ultrasonic excitation device;

所述超声激励装置基于所述超声激励参数产生对应的超声波,并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备;The ultrasonic excitation device generates corresponding ultrasonic waves based on the ultrasonic excitation parameters, and sends the ultrasonic echo data to the computer equipment after collecting the ultrasonic echo data;

所述计算机设备根据所述超声回波数据进行超声成像后输出可视化图像。The computer device performs ultrasound imaging according to the ultrasound echo data and outputs a visualized image.

相对于现有技术而言,本发明具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:

本发明实施例提供一种超声激励装置、方法及系统,通过波形发生器获得各个通道的超声激励参数后生成每个通道的波形激励信号,功率放大器将波形激励信号进行功率放大,生成高压驱动信号并输入给超声换能器阵列,超声换能器阵列根据高压驱动信号在相应的阵元上产生超声波。由此,可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号,对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制,从而可以充分发挥超声换能器的性能,获得更佳的超声力学效应以及热效应。Embodiments of the present invention provide an ultrasonic excitation device, method, and system. After obtaining the ultrasonic excitation parameters of each channel through a waveform generator, a waveform excitation signal for each channel is generated. The power amplifier amplifies the power of the waveform excitation signal to generate a high-voltage drive signal. And input to the ultrasonic transducer array, the ultrasonic transducer array generates ultrasonic waves on the corresponding array elements according to the high-voltage driving signal. Therefore, the ultrasonic excitation parameters of each channel can be flexibly configured to generate an arbitrary waveform excitation signal, and the excitation signal of each array element in the ultrasonic transducer array can be independently controlled, so that the performance of the ultrasonic transducer can be fully utilized , to obtain better ultrasonic mechanical effect and thermal effect.

附图说明Description of drawings

为了更清楚地说明本发明实施例的技术方案,下面将对实施例中所需要使用的附图作简单地介绍,应当理解,以下附图仅示出了本发明的某些实施例,因此不应被看作是对范围的限定,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其它相关的附图。In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention, and thus It should be regarded as a limitation on the scope, and those skilled in the art can also obtain other related drawings based on these drawings without creative work.

图1为本发明较佳实施例提供的超声激励系统的一种结构框图;Fig. 1 is a kind of block diagram of the ultrasonic excitation system that the preferred embodiment of the present invention provides;

图2为一种实施方式中激励信号的一种波形图;Fig. 2 is a kind of waveform diagram of excitation signal in an embodiment;

图3为本发明较佳实施例提供的超声激励系统的另一种结构框图;Fig. 3 is another structural block diagram of the ultrasonic excitation system provided by the preferred embodiment of the present invention;

图4为本发明较佳实施例提供的超声激励系统的另一种结构框图;Fig. 4 is another structural block diagram of the ultrasonic excitation system provided by the preferred embodiment of the present invention;

图5为本发明较佳实施例提供的超声激励系统的另一种结构框图;Fig. 5 is another structural block diagram of the ultrasonic excitation system provided by the preferred embodiment of the present invention;

图6为本发明较佳实施例提供的超声激励方法的一种流程示意图。Fig. 6 is a schematic flowchart of an ultrasonic excitation method provided by a preferred embodiment of the present invention.

图标:10-超声激励系统;100-超声激励装置;110-波形发生器;112-通讯接口;114-信号处理器;1142-通讯处理单元;1144-逻辑处理单元;1146-波束合成单元;116-数模转换器阵列;120-功率放大器;130-超声换能器阵列;140-回波采集模块;142-超声模拟前端放大单元;144-模拟信号采集单元;150-回波成像模块;200-计算机设备。Icons: 10-ultrasonic excitation system; 100-ultrasonic excitation device; 110-waveform generator; 112-communication interface; 114-signal processor; 1142-communication processing unit; 1144-logic processing unit; 1146-beam forming unit; 116 -Digital-to-analog converter array; 120-power amplifier; 130-ultrasonic transducer array; 140-echo acquisition module; 142-ultrasonic analog front-end amplification unit; 144-analog signal acquisition unit; 150-echo imaging module; 200 -Computer equipment.

具体实施方式Detailed ways

目前,医学超声技术已经广泛应用于临床诊断与治疗。超声诊断主要是利用超声回波获取组织的影像学信息,为临床医生提供必要的诊断参考。超声治疗则是利用了超声波的力学效应、热效应以及空化效应,用于疾病的治疗。具体而言,又可以分为高剂量的超声热消融技术和低剂量的超声波调控技术。高强度聚焦超声(HIFU)就是一种典型的超声热消融技术,HIFU可以穿透组织,到达设定的目标区域,用来破坏体内的肿瘤,最后通过机体自身的免疫系统吸收掉被破坏的肿瘤,达到无创治疗的功效。低剂量超声治疗主要应用有:超声血管溶栓、基于超声波的血脑屏障开启以及超声神经调控。所谓的超声血管溶栓,即利用超声波来破坏、疏通血斑,以达到治疗的目的。血脑屏障是指在血管和脑之间有选择性地阻止某些物质由血液进入脑的屏障,通常这对于机体的保护,是有益的。但是,同样会削弱药物对病人的治疗效果。而聚焦超声波可以暂时解除血脑屏障,令药物可以穿过屏障到达脑部,有效提高药物治疗的效果。超声神经调控,即通过超声刺激神经,引起神经系统兴奋或抑制,调节生物体的神经活动,改变神经环路的响应,从而有助于神经性精神疾病的治疗。超声神经调控,通过人为干预生物活体的神经环路,进而开展大脑机能(如认知、感受等)的研究,而成为一种有效的手段。At present, medical ultrasound technology has been widely used in clinical diagnosis and treatment. Ultrasound diagnosis mainly uses ultrasound echoes to obtain imaging information of tissues, and provides necessary diagnostic references for clinicians. Ultrasound therapy uses the mechanical effect, thermal effect and cavitation effect of ultrasound to treat diseases. Specifically, it can be divided into high-dose ultrasonic thermal ablation technology and low-dose ultrasonic regulation technology. High Intensity Focused Ultrasound (HIFU) is a typical ultrasonic thermal ablation technology. HIFU can penetrate tissues and reach the set target area to destroy tumors in the body, and finally absorb the destroyed tumors through the body's own immune system , to achieve the effect of non-invasive treatment. The main applications of low-dose ultrasound therapy are: ultrasound vascular thrombolysis, ultrasound-based opening of the blood-brain barrier, and ultrasound neuromodulation. The so-called ultrasonic vascular thrombolysis, that is, the use of ultrasound to destroy and dredge blood spots, in order to achieve the purpose of treatment. The blood-brain barrier refers to the barrier between the blood vessels and the brain that selectively prevents certain substances from entering the brain from the blood, which is generally beneficial to the protection of the body. But, equally can weaken the therapeutic effect of medicine to patient. Focused ultrasound can temporarily release the blood-brain barrier, allowing drugs to pass through the barrier to reach the brain, effectively improving the effect of drug treatment. Ultrasound neuromodulation is to stimulate nerves through ultrasound to cause excitation or inhibition of the nervous system, regulate the neural activity of organisms, and change the response of neural circuits, thereby contributing to the treatment of neuropsychiatric diseases. Ultrasonic neuromodulation has become an effective method to carry out research on brain functions (such as cognition, feeling, etc.) by artificially intervening in the neural circuits of living organisms.

目前,经本申请发明人研究发现,常用的方案是基于单阵元自聚焦换能器的超声系统,该方案的优势是系统复杂度低,便于实施。但是缺点也很明显,如超声聚焦模式单一,刺激靶点定位不准确等问题。为了解决焦点移动、定位困难的问题,基于阵列式超声换能器的超声系统被提出,这种方案,采用电子扫描的方式,可以灵活的改变相控阵超声换能器的焦点位置,较好地解决了前者的缺陷。At present, the inventors of the present application have found that the commonly used solution is an ultrasound system based on a single-element self-focusing transducer. The advantage of this solution is that the system has low complexity and is easy to implement. However, the disadvantages are also obvious, such as the single ultrasonic focusing mode and inaccurate positioning of stimulation targets. In order to solve the problem of focal point movement and difficult positioning, an ultrasonic system based on array ultrasonic transducers was proposed. This solution, using electronic scanning, can flexibly change the focal position of the phased array ultrasonic transducer, which is better. address the shortcomings of the former.

而实际上,发明人在研究过程中发现超声换能器都有一定的带宽,在该带宽范围内的激励信号都有着较高电声转化效率。经发明人长期研究,发现如果采用两种或多种频率接近的激励信号同时激励超声换能器,形成新型的激励序列,在诸如血脑屏障的打开、聚焦区域的热消融等应用中可以获得更好的效果。但是在当前的现有技术中,多是利用单一的正弦波或者方波激励超声换能器,很难取得这样的效果。并且,当前现有的设备硬件上多采用类似于直接数字式频率合成器的方法来生成激励信号,很难通过软件算法来补偿这一缺陷。In fact, during the research process, the inventors found that ultrasonic transducers all have a certain bandwidth, and excitation signals within this bandwidth range have relatively high electroacoustic conversion efficiency. After long-term research by the inventor, it is found that if two or more excitation signals with similar frequencies are used to simultaneously excite the ultrasonic transducer to form a new excitation sequence, it can be obtained in applications such as the opening of the blood-brain barrier and thermal ablation of the focal region. better effect. However, in the current prior art, a single sine wave or square wave is mostly used to excite the ultrasonic transducer, and it is difficult to achieve such an effect. Moreover, the current existing equipment hardware mostly uses methods similar to direct digital frequency synthesizers to generate excitation signals, and it is difficult to compensate for this defect through software algorithms.

鉴于上述问题,经本申请发明人长期研究探索,提出下述实施例,用于提高超声治疗的效果,可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号,对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制,从而可以充分发挥超声换能器的性能,获得更佳的超声力学效应以及热效应,在此基础上,相关人员可以设计新型的激励波形与激励序列,从而实现更多元化的激励波形以及聚焦方式,为超声治疗提供更好的设备基础。下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。通常在此处附图中描述和示出的本发明实施例的组件可以以各种不同的配置来布置和设计。In view of the above problems, after long-term research and exploration by the inventors of the present application, the following embodiments are proposed to improve the effect of ultrasonic therapy, and the ultrasonic excitation parameters of each channel can be flexibly configured to generate excitation signals of arbitrary waveforms. For ultrasonic transducer arrays The excitation signal of each element in the array can be independently controlled, so that the performance of the ultrasonic transducer can be fully utilized, and better ultrasonic mechanical effects and thermal effects can be obtained. On this basis, relevant personnel can design new excitation waveforms and excitation sequence, so as to achieve more diversified excitation waveforms and focusing methods, and provide a better equipment basis for ultrasound therapy. The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some of the embodiments of the present invention, but not all of them. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

因此,以下对在附图中提供的本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围,而是仅仅表示本发明的选定实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例,都属于本发明保护的范围。Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

应注意到:相似的标号和字母在下面的附图中表示类似项,因此,一旦某一项在一个附图中被定义,则在随后的附图中不需要对其进行进一步定义和解释。It should be noted that like numerals and letters denote similar items in the following figures, therefore, once an item is defined in one figure, it does not require further definition and explanation in subsequent figures.

请参阅图1,为本发明较佳实施例提供的超声激励系统10的一种结构框图。本实施例中,所述超声激励系统10可包括计算机设备200以及超声激励装置100。所述计算机设备200与所述超声激励装置100通信连接,用于向所述超声激励装置100发送各个通道的超声激励参数。所述超声激励装置100基于所述超声激励参数产生对应的超声波,并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备200。所述计算机设备200根据所述超声回波数据进行超声成像后输出可视化图像。Please refer to FIG. 1 , which is a structural block diagram of an ultrasonic excitation system 10 provided by a preferred embodiment of the present invention. In this embodiment, the ultrasonic excitation system 10 may include a computer device 200 and an ultrasonic excitation device 100 . The computer equipment 200 is communicatively connected with the ultrasonic excitation device 100 for sending ultrasonic excitation parameters of each channel to the ultrasonic excitation device 100 . The ultrasonic excitation device 100 generates corresponding ultrasonic waves based on the ultrasonic excitation parameters, and sends the ultrasonic echo data to the computer device 200 after collecting the ultrasonic echo data. The computer device 200 performs ultrasound imaging according to the ultrasound echo data and outputs a visualized image.

本实施例中,所述计算机设备200可以是包括硬体、软体或内嵌逻辑元件或者两个或多个此类元件的组合的电子装置,并能够执行由计算机设备200实施或支援的合适的功能。所述计算机设备200可以是一种具有无线收发功能的设备,包括室内或室外、手持、穿戴或车载设备。例如,所述计算机设备200可以是手机(Mobile Phone)、平板电脑(Pad)、个人电脑(Personal Computer,PC)、带无线收发功能的电脑、虚拟现实(Virtual Reality,VR)终端、增强现实(Augmented Reality,AR)终端、工业控制(Industrial Control)中的无线终端、无人驾驶(Self Driving)中的无线终端、远程医疗(Remote Medical)中的无线终端、智能电网(Smart Grid)中的无线终端、运输安全(Transportation Safety)中的无线终端、智慧城市(Smart City)中的无线终端、智慧家庭(Smart Home)中的无线终端等等。本实施例对应用场景不做限定。In this embodiment, the computer device 200 may be an electronic device including hardware, software, or embedded logic elements or a combination of two or more such elements, and is capable of executing suitable programs implemented or supported by the computer device 200 Function. The computer device 200 may be a device with a wireless transceiver function, including indoor or outdoor, handheld, wearable or vehicle-mounted devices. For example, the computer device 200 may be a mobile phone (Mobile Phone), a tablet computer (Pad), a personal computer (Personal Computer, PC), a computer with a wireless transceiver function, a virtual reality (Virtual Reality, VR) terminal, an augmented reality ( Augmented Reality, AR) terminals, wireless terminals in Industrial Control, wireless terminals in Self Driving, wireless terminals in Remote Medical, wireless in Smart Grid Terminals, wireless terminals in Transportation Safety, wireless terminals in Smart City, wireless terminals in Smart Home, etc. This embodiment does not limit the application scenario.

具体地,所述计算机设备200可作为上位机,提供用于配置各个通道的超声激励参数的交互界面,用户可以根据实际情况需要在该交互界面配置各个通道的超声激励参数,以生成相关的控制指令发送至所述超声激励装置100,所述超声激励装置100可基于各个通道的超声激励参数在相应的阵元上产生超声波。Specifically, the computer device 200 can be used as a host computer to provide an interactive interface for configuring the ultrasonic excitation parameters of each channel, and the user can configure the ultrasonic excitation parameters of each channel on the interactive interface according to actual needs to generate related control parameters. The instruction is sent to the ultrasonic excitation device 100, and the ultrasonic excitation device 100 can generate ultrasonic waves on corresponding array elements based on the ultrasonic excitation parameters of each channel.

值得说明的是,所述超声激励装置100也可以不仅限于上述方式获得各个通道的超声激励参数,也可通过超声激励装置100本身提供的配置按键获得,或者通过远程服务器获得,本实施例对超声激励装置100获得超声激励参数的方式不作详细限制。It is worth noting that the ultrasonic excitation device 100 can also obtain the ultrasonic excitation parameters of each channel not only in the above-mentioned manner, but can also be obtained through the configuration buttons provided by the ultrasonic excitation device 100 itself, or obtained through a remote server. The manner in which the excitation device 100 obtains the ultrasonic excitation parameters is not limited in detail.

下面以所述超声激励装置100通过作为上位机的计算机设备200获得超声激励参数为例,对所述超声激励装置100的结构进行详述。如图1所示,所述超声激励装置100可以包括波形发生器110、功率放大器120以及超声换能器阵列130。所述波形发生器110用于获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号。所述功率放大器120与所述波形发生器110电性连接,用于将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列130。所述超声换能器阵列130用于根据所述高压驱动信号在相应的阵元上产生超声波。The structure of the ultrasonic excitation device 100 will be described in detail below by taking the ultrasonic excitation device 100 obtaining ultrasonic excitation parameters through the computer device 200 as a host computer as an example. As shown in FIG. 1 , the ultrasonic excitation device 100 may include a waveform generator 110 , a power amplifier 120 and an ultrasonic transducer array 130 . The waveform generator 110 is configured to generate a waveform excitation signal of each channel according to the ultrasonic excitation parameters after obtaining the ultrasonic excitation parameters of each channel. The power amplifier 120 is electrically connected to the waveform generator 110 , and is used to amplify the power of the waveform excitation signal to generate a high voltage driving signal and input it to the ultrasonic transducer array 130 . The ultrasonic transducer array 130 is used to generate ultrasonic waves on corresponding array elements according to the high-voltage driving signal.

详细地,所述超声激励参数可包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率。所述超声换能器阵列130可包括多个阵元,每个阵元对应一个通道。在本实施例中,所述超声激励参数可以由相关用户灵活配置,从而可以根据用户需要产生任意波形的激励信号,因此对于超声换能器阵列130中的每一个阵元的激励信号都可以进行独立控制,例如可为同频率波形,也可为不同频率波形,同一阵元也可以用含有多个频率的波形进行激励,每通道波形按照一定规则进行时序排列,所述激励信号还可以采用连续波、短脉冲波以及长脉冲波。如此,充分发挥了超声换能器的性能,获得更佳的超声力学效应以及热效应,使得在诸如血脑屏障打开、超声热消融等应用中可以获得更佳的效果。在此基础上,相关人员可以设计新型的激励波形与激励序列,从而实现更多元化的激励波形以及聚焦方式,为超声治疗提供更好的设备基础。In detail, the ultrasonic excitation parameters may include at least one of waveform shape, signal frequency, signal amplitude, and focusing parameters, and the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency. The ultrasonic transducer array 130 may include multiple array elements, and each array element corresponds to a channel. In this embodiment, the ultrasonic excitation parameters can be flexibly configured by relevant users, so that excitation signals of arbitrary waveforms can be generated according to user needs, so the excitation signals of each array element in the ultrasonic transducer array 130 can be Independent control, for example, it can be the same frequency waveform or different frequency waveforms. The same array element can also be excited by waveforms containing multiple frequencies. The waveforms of each channel are arranged in time sequence according to certain rules. waves, short pulse waves, and long pulse waves. In this way, the performance of the ultrasonic transducer is fully utilized to obtain better ultrasonic mechanical effects and thermal effects, so that better effects can be obtained in applications such as opening of the blood-brain barrier and ultrasonic thermal ablation. On this basis, relevant personnel can design new excitation waveforms and excitation sequences, so as to realize more diversified excitation waveforms and focusing methods, and provide a better equipment basis for ultrasound therapy.

其中,所述波形形状可以是指正弦波、方波以及多种频率正弦合成后的波形,所述信号频率可以是指该波形信号的信号变化周期,当采用多种正弦复合后的波形时可包含多种频率。另外,如果采用脉冲波激励还需要配置脉冲的重复频率。所述信号幅度可以是指指信号电压上下波动的范围。所述聚焦参数可以是指信号的聚焦方式。Wherein, the waveform shape may refer to a sine wave, a square wave, and a sinusoidally synthesized waveform of various frequencies, and the signal frequency may refer to the signal change period of the waveform signal. When multiple sinusoidal composite waveforms are used, it may Contains multiple frequencies. In addition, if pulse wave excitation is used, the pulse repetition frequency needs to be configured. The signal amplitude may refer to the range in which the signal voltage fluctuates up and down. The focus parameter may refer to a signal focus mode.

例如,在图2所示的波形图中,列举了三种典型的不同激励波形,分别是单频率正弦波信号、单频率正弦波与载波调制后的信号以及双频率正弦波的合成信号,当采用多种正弦复合后的波形时,此时该双频率正弦波的合成信号种包含多种频率。在实际应用中,仍然可以根据实际情况设计其它激励信号,只需要对设计的激励信号进行采样,计算出对应采样点处的激励参数和其它控制参数(例如,放大倍数、脉冲重复频率等)下发到波形发生器110即可合成出所设计的激励信号。由此,可以避免传统方法只能产生单一波形激励信号的缺陷,更好地利用超声换能器的带宽,能够在不同的应用中获得更好的超声力学效应以及热效应。而在实际应用场景中,通过采用图2中所示的调制波或者双频正弦波激励所述超声换能器给目标组织加热时,温度上升更快,加热时间减短,在诸如血脑屏障打开、超声热消融等应用中可以获得更佳的效果。For example, in the waveform diagram shown in Figure 2, three typical different excitation waveforms are listed, which are single-frequency sine wave signal, signal modulated by single-frequency sine wave and carrier wave, and composite signal of dual-frequency sine wave. When multiple sinusoidal composite waveforms are used, the composite signal of the dual-frequency sinusoidal wave includes multiple frequencies. In practical applications, other excitation signals can still be designed according to the actual situation. It is only necessary to sample the designed excitation signal and calculate the excitation parameters at the corresponding sampling points and other control parameters (such as amplification factor, pulse repetition frequency, etc.) The designed excitation signal can be synthesized by sending it to the waveform generator 110 . Therefore, the defect that the traditional method can only generate a single waveform excitation signal can be avoided, the bandwidth of the ultrasonic transducer can be better utilized, and better ultrasonic mechanical effects and thermal effects can be obtained in different applications. However, in practical application scenarios, when the ultrasonic transducer is excited by the modulated wave or dual-frequency sine wave shown in Figure 2 to heat the target tissue, the temperature rises faster and the heating time is shortened. Better results can be obtained in applications such as opening and ultrasonic thermal ablation.

下面对所述波形发生器110的结构进行说明,请参阅图3,所述波形发生器110可包括通讯接口112、信号处理器114以及数模转换器阵列116。详细地,所述信号处理器114分别与所述通讯接口112和所述数模转换器阵列116电性连接,用于控制所述通讯接口112接收每个通道的超声激励参数,并根据所述超声激励参数生成对应的通道的波形激励信号,接着再将所述波形激励信号写入所述数模转换器阵列116中对应的数模转换器中。所述数模转换器可将所述波形激励信号转换为模拟信号并输出至所述功率放大器120。由此,可以实现对所述每个通道的超声激励参数的接收、波形激励信号的生成以及波形激励信号的数模转换。The structure of the waveform generator 110 will be described below. Please refer to FIG. 3 . The waveform generator 110 may include a communication interface 112 , a signal processor 114 and a digital-to-analog converter array 116 . In detail, the signal processor 114 is electrically connected to the communication interface 112 and the digital-to-analog converter array 116 respectively, and is used to control the communication interface 112 to receive the ultrasonic excitation parameters of each channel, and according to the The ultrasonic excitation parameters generate waveform excitation signals of corresponding channels, and then write the waveform excitation signals into corresponding digital-to-analog converters in the digital-to-analog converter array 116 . The digital-to-analog converter can convert the waveform excitation signal into an analog signal and output it to the power amplifier 120 . In this way, the reception of the ultrasonic excitation parameters of each channel, the generation of the waveform excitation signal, and the digital-to-analog conversion of the waveform excitation signal can be realized.

在一种实施方式中,所述信号处理器114可以包括现场可编程门阵列或者数字信号处理器114。In one embodiment, the signal processor 114 may include a field programmable gate array or a digital signal processor 114 .

在一种实施方式中,所述信号处理器114包括通讯处理单元1142、逻辑处理单元1144以及波束合成单元1146。所述通讯处理单元1142用于控制所述通讯接口112,所述逻辑处理单元1144用于根据所述超声激励参数生成各个通道的波形激励信号,并将所述波形激励信号写入所述数模转换器阵列116,所述波束合成单元1146用于根据聚焦参数将产生的波形激励信号进行相位延时,以合成特定声场,提高实际应用效果。In one implementation manner, the signal processor 114 includes a communication processing unit 1142 , a logic processing unit 1144 and a beam forming unit 1146 . The communication processing unit 1142 is used to control the communication interface 112, and the logic processing unit 1144 is used to generate waveform excitation signals of each channel according to the ultrasonic excitation parameters, and write the waveform excitation signals into the digital-analog The converter array 116, the beam synthesis unit 1146 is used to phase-delay the generated waveform excitation signal according to the focusing parameters, so as to synthesize a specific sound field and improve the actual application effect.

在一种实施方式中,所述信号处理器114还用于控制所述通讯接口112接收控制参数,并根据所述控制参数控制所述数模转换器阵列116以及所述功率放大器120的工作状态。所述控制参数可以包括功率放大倍数、脉冲重复频率、发射控制参数、回波接收控制参数中的至少一种或者多种组合。所述功率放大倍数可以是指所述功率放大器120放大激励信号的倍数,同时,当采用脉冲波激励需要配置脉冲重复频率。发射控制参数、回波接收控制参数可以是指在发射激励信号时和接收回波信号的控制参数。In one embodiment, the signal processor 114 is also used to control the communication interface 112 to receive control parameters, and control the working states of the digital-to-analog converter array 116 and the power amplifier 120 according to the control parameters . The control parameters may include at least one or a combination of multiples of power amplification, pulse repetition frequency, transmission control parameters, and echo reception control parameters. The power amplification factor may refer to the multiple of the excitation signal amplified by the power amplifier 120, and at the same time, when pulse wave excitation is used, a pulse repetition frequency needs to be configured. The transmission control parameter and the echo reception control parameter may refer to control parameters when the excitation signal is transmitted and the echo signal is received.

在一种实施方式中,所述超声换能器阵列130可以为多阵元的相控阵换能器,可以为平面型也可以为弧面型,超声换能器阵元可以是有规则的分布也可以是随机分布。此外,超声换能器阵元可以采用超声刺激、成像双模换能器。双模换能器可以实现实时成像监测超声刺激靶点的功能,为移动超声聚焦焦点提供更精准的支持。在这一情形下,所述超声换能器包括激励探头和成像探头,所述激励探头用于根据高压驱动信号产生超声波,所述成像探头用于在探测超声回波以用于成像监测。In one embodiment, the ultrasonic transducer array 130 can be a multi-element phased array transducer, which can be planar or curved, and the ultrasonic transducer arrays can be regular The distribution can also be a random distribution. In addition, the ultrasonic transducer array element can adopt ultrasonic stimulation and imaging dual-mode transducers. The dual-mode transducer can realize the function of real-time imaging and monitoring of ultrasound stimulation targets, and provide more precise support for moving the focus of ultrasound. In this case, the ultrasonic transducer includes an excitation probe for generating ultrasonic waves according to a high-voltage driving signal, and an imaging probe for detecting ultrasonic echoes for imaging monitoring.

进一步地,在探测到超声回波的基础上,请参阅图4,所述超声激励装置100还可以包括回波采集模块140和回波成像模块150。具体地,所述回波采集模块140,用于在采集到经由所述超声换能器阵列130探测到的超声回波信号后进行信号处理,并将处理后的超声回波信号转换为数字信号。所述回波成像模块150与所述回波采集模块140电性连接,用于根据波束合成参数对所述数字信号进行信号处理,得到对应的超声回波数据,并将所述超声回波数据传输给计算机设备200进行超声成像,从而为用户决策提供支持。Further, on the basis of detecting the ultrasonic echo, please refer to FIG. 4 , the ultrasonic excitation device 100 may further include an echo acquisition module 140 and an echo imaging module 150 . Specifically, the echo collection module 140 is configured to perform signal processing after collecting the ultrasonic echo signals detected by the ultrasonic transducer array 130, and convert the processed ultrasonic echo signals into digital signals . The echo imaging module 150 is electrically connected to the echo acquisition module 140, and is used to perform signal processing on the digital signal according to beamforming parameters to obtain corresponding ultrasonic echo data, and convert the ultrasonic echo data to It is transmitted to the computer device 200 for ultrasound imaging, thereby providing support for user decision-making.

更为具体地,请参阅图5,所述回波采集模块140可包括超声模拟前端放大单元142和模拟信号采集单元144。所述超声模拟前端放大单元142与所述模拟信号采集单元144电性连接,用于对所述超声回波信号经过前置放大、滤波、压控放大后发送给所述模拟信号采集单元144进行模数转换后,输出数字信号。由此,通过超声激励与回波成像一体化,集成度更好,能够实现超声图像自引导治疗。More specifically, referring to FIG. 5 , the echo acquisition module 140 may include an ultrasonic analog front-end amplification unit 142 and an analog signal acquisition unit 144 . The ultrasonic analog front-end amplification unit 142 is electrically connected to the analog signal acquisition unit 144, and is used to send the ultrasonic echo signal to the analog signal acquisition unit 144 after pre-amplification, filtering, and voltage-controlled amplification. After analog-to-digital conversion, a digital signal is output. Therefore, through the integration of ultrasound excitation and echo imaging, the degree of integration is better, and ultrasound image self-guided therapy can be realized.

进一步地,请参阅图6,本发明较佳实施例还提供一种超声激励方法,可以理解的是,接下来要描述的超声激励方法中涉及的步骤在上面实施例中已经描述过,具体各个步骤的详尽内容可参照上面的实施例描述,下面仅对超声激励方法执行步骤进行简要说明。所述方法可以包括:Further, please refer to FIG. 6 , the preferred embodiment of the present invention also provides an ultrasonic excitation method. It can be understood that the steps involved in the ultrasonic excitation method to be described next have been described in the above embodiments, and each The detailed content of the steps can be described with reference to the above embodiments, and only the steps of the ultrasonic excitation method will be briefly described below. The method can include:

步骤S110,所述波形发生器110获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号。Step S110, after the waveform generator 110 obtains the ultrasonic excitation parameters of each channel, generates a waveform excitation signal of each channel according to the ultrasonic excitation parameters.

所述超声激励参数包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率。The ultrasonic excitation parameters include at least one of waveform shape, signal frequency, signal amplitude, and focusing parameters, and the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency.

步骤S120,所述功率放大器120将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列130。Step S120 , the power amplifier 120 amplifies the power of the waveform excitation signal to generate a high voltage driving signal and input it to the ultrasonic transducer array 130 .

步骤S130,所述超声换能器阵列130根据所述高压驱动信号在相应的阵元上产生超声波。Step S130, the ultrasonic transducer array 130 generates ultrasonic waves on corresponding array elements according to the high-voltage driving signal.

所述超声换能器阵列130包括有多个阵元,每个阵元对应一个通道。The ultrasonic transducer array 130 includes a plurality of array elements, and each array element corresponds to a channel.

综上所述,本发明实施例提供一种超声激励装置、方法及系统,通过波形发生器获得各个通道的超声激励参数后生成每个通道的波形激励信号,功率放大器将波形激励信号进行功率放大,生成高压驱动信号并输入给超声换能器阵列,超声换能器阵列根据高压驱动信号在相应的阵元上产生超声波。由此,可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号,对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制,从而可以充分发挥超声换能器的性能,获得更佳的超声力学效应以及热效应。In summary, the embodiments of the present invention provide an ultrasonic excitation device, method, and system. After obtaining the ultrasonic excitation parameters of each channel through a waveform generator, a waveform excitation signal for each channel is generated, and the power amplifier amplifies the power of the waveform excitation signal. , generate a high-voltage driving signal and input it to the ultrasonic transducer array, and the ultrasonic transducer array generates ultrasonic waves on corresponding array elements according to the high-voltage driving signal. Therefore, the ultrasonic excitation parameters of each channel can be flexibly configured to generate an arbitrary waveform excitation signal, and the excitation signal of each array element in the ultrasonic transducer array can be independently controlled, so that the performance of the ultrasonic transducer can be fully utilized , to obtain better ultrasonic mechanical effect and thermal effect.

需要说明的是,在本文中,术语"包括"、"包含"或者其任何其它变体意在涵盖非排它性的包含,从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素,而且还包括没有明确列出的其它要素,或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下,由语句"包括一个……"限定的要素,并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。It should be noted that, in this document, the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or device comprising a series of elements includes not only those elements, but also other elements not expressly listed, or elements inherent in the process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising a..." does not preclude the presence of additional identical elements in the process, method, article or apparatus comprising said element.

对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其它的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。It will be apparent to those skilled in the art that the invention is not limited to the details of the above-described exemplary embodiments, but that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Accordingly, the embodiments should be regarded in all points of view as exemplary and not restrictive, the scope of the invention being defined by the appended claims rather than the foregoing description, and it is therefore intended that the scope of the invention be defined by the appended claims rather than by the foregoing description. All changes within the meaning and range of equivalents of the elements are embraced in the present invention. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (10)

1.一种超声激励装置,其特征在于,所述超声激励装置包括波形发生器、功率放大器以及超声换能器阵列;1. An ultrasonic excitation device, characterized in that, the ultrasonic excitation device comprises a waveform generator, a power amplifier and an array of ultrasonic transducers; 所述波形发生器用于获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号;After the waveform generator is used to obtain the ultrasonic excitation parameters of each channel, generate the waveform excitation signal of each channel according to the ultrasonic excitation parameters; 所述功率放大器与所述波形发生器电性连接,用于将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列;The power amplifier is electrically connected to the waveform generator, and is used to amplify the power of the waveform excitation signal, generate a high-voltage driving signal and input it to the ultrasonic transducer array; 所述超声换能器阵列用于根据所述高压驱动信号在相应的阵元上产生超声波,其中,所述超声换能器阵列包括有多个阵元,每个阵元对应一个通道。The ultrasonic transducer array is used to generate ultrasonic waves on corresponding array elements according to the high-voltage driving signal, wherein the ultrasonic transducer array includes a plurality of array elements, and each array element corresponds to a channel. 2.根据权利要求1所述的超声激励装置,其特征在于,其中,所述超声激励参数包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率。2. The ultrasonic excitation device according to claim 1, wherein the ultrasonic excitation parameters include at least one of waveform shape, signal frequency, signal amplitude, and focusing parameters, and the signal frequency includes a single frequency Waveform frequency or composite frequency waveform frequency. 3.根据权利要求1所述的超声激励装置,其特征在于,所述波形发生器包括通讯接口、信号处理器以及数模转换器阵列;3. The ultrasonic excitation device according to claim 1, wherein the waveform generator comprises a communication interface, a signal processor and a digital-to-analog converter array; 所述信号处理器分别与所述通讯接口和所述数模转换器阵列电性连接,用于控制所述通讯接口接收每个通道的超声激励参数,并根据所述超声激励参数生成对应的通道的波形激励信号,再将所述波形激励信号写入所述数模转换器阵列中对应的数模转换器中,以通过所述数模转换器将所述波形激励信号转换为模拟信号并输出至所述功率放大器。The signal processor is electrically connected to the communication interface and the digital-to-analog converter array respectively, and is used to control the communication interface to receive ultrasonic excitation parameters of each channel, and generate corresponding channels according to the ultrasonic excitation parameters The waveform excitation signal, and then write the waveform excitation signal into the corresponding digital-to-analog converter in the digital-to-analog converter array, so that the waveform excitation signal is converted into an analog signal by the digital-to-analog converter and output to the power amplifier. 4.根据权利要求3所述的超声激励装置,其特征在于,所述信号处理器还用于控制所述通讯接口接收控制参数,并根据所述控制参数控制所述数模转换器阵列以及所述功率放大器的工作状态,其中,所述控制参数包括功率放大倍数、脉冲重复频率、发射控制参数、回波接收控制参数中的至少一种或者多种组合。4. The ultrasonic excitation device according to claim 3, wherein the signal processor is also used to control the communication interface to receive control parameters, and control the digital-to-analog converter array and the The working state of the power amplifier, wherein the control parameters include at least one or a combination of power amplification factor, pulse repetition frequency, transmission control parameters, and echo reception control parameters. 5.根据权利要求3所述的超声激励装置,其特征在于,所述信号处理器包括:5. The ultrasonic excitation device according to claim 3, wherein the signal processor comprises: 用于控制所述通讯接口的通讯处理单元;a communication processing unit for controlling the communication interface; 用于根据所述超声激励参数生成各个通道的波形激励信号,并将所述波形激励信号写入所述数模转换器阵列的逻辑处理单元;以及A logic processing unit for generating a waveform excitation signal of each channel according to the ultrasonic excitation parameters, and writing the waveform excitation signal into the digital-to-analog converter array; and 用于根据聚焦参数将产生的波形激励信号进行相位延时的波束合成单元。A beamforming unit for phase-delaying the generated waveform excitation signal according to the focusing parameters. 6.根据权利要求1所述的超声激励装置,其特征在于,所述超声激励装置还包括回波采集模块和回波成像模块;6. The ultrasonic excitation device according to claim 1, wherein the ultrasonic excitation device further comprises an echo acquisition module and an echo imaging module; 所述回波采集模块,用于在采集到经由所述超声换能器阵列探测到的超声回波信号后进行信号处理,并将处理后的超声回波信号转换为数字信号;The echo collection module is configured to perform signal processing after collecting the ultrasonic echo signals detected by the ultrasonic transducer array, and convert the processed ultrasonic echo signals into digital signals; 所述回波成像模块与所述回波采集模块电性连接,用于根据波束合成参数对所述数字信号进行信号处理,得到对应的超声回波数据,并将所述超声回波数据传输给计算机设备进行超声成像。The echo imaging module is electrically connected to the echo acquisition module, and is used to perform signal processing on the digital signal according to beamforming parameters to obtain corresponding ultrasonic echo data, and transmit the ultrasonic echo data to Computer equipment for ultrasound imaging. 7.根据权利要求6所述的超声激励装置,其特征在于,所述回波采集模块包括超声模拟前端放大单元和模拟信号采集单元;7. The ultrasonic excitation device according to claim 6, wherein the echo acquisition module comprises an ultrasonic analog front-end amplification unit and an analog signal acquisition unit; 所述超声模拟前端放大单元与所述模拟信号采集单元电性连接,用于对所述超声回波信号经过前置放大、滤波、压控放大后发送给所述模拟信号采集单元进行模数转换后,输出数字信号。The ultrasonic analog front-end amplification unit is electrically connected to the analog signal acquisition unit, and is used to send the ultrasonic echo signal to the analog signal acquisition unit for analog-to-digital conversion after pre-amplification, filtering, and voltage-controlled amplification After that, a digital signal is output. 8.根据权利要求1所述的超声激励装置,其特征在于,所述超声换能器阵列包括激励探头和成像探头;8. The ultrasonic excitation device according to claim 1, wherein the ultrasonic transducer array comprises an excitation probe and an imaging probe; 所述激励探头用于根据高压驱动信号产生超声波;The excitation probe is used to generate ultrasonic waves according to the high-voltage driving signal; 所述成像探头用于在探测超声回波以用于成像监测。The imaging probe is used to detect ultrasonic echoes for imaging monitoring. 9.一种超声激励方法,应用于权利要求1-8中任意一项所述的超声激励装置,其特征在于,所述方法包括:9. An ultrasonic excitation method, applied to the ultrasonic excitation device described in any one of claims 1-8, characterized in that the method comprises: 所述波形发生器获得各个通道的超声激励参数后,根据所述超声激励参数生成每个通道的波形激励信号,其中,所述超声激励参数包括有波形形状、信号频率、信号幅度、聚焦参数中的至少一种,所述信号频率包括单频率波形频率或者复合频率波形频率;After the waveform generator obtains the ultrasonic excitation parameters of each channel, it generates the waveform excitation signal of each channel according to the ultrasonic excitation parameters, wherein the ultrasonic excitation parameters include waveform shape, signal frequency, signal amplitude, and focusing parameters. At least one of, the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency; 所述功率放大器将所述波形激励信号进行功率放大,生成高压驱动信号并输入给所述超声换能器阵列;The power amplifier amplifies the power of the waveform excitation signal to generate a high-voltage driving signal and input it to the ultrasonic transducer array; 所述超声换能器阵列根据所述高压驱动信号在相应的阵元上产生超声波,其中,所述超声换能器阵列包括有多个阵元,每个阵元对应一个通道。The ultrasonic transducer array generates ultrasonic waves on corresponding array elements according to the high-voltage driving signal, wherein the ultrasonic transducer array includes a plurality of array elements, and each array element corresponds to a channel. 10.一种超声激励系统,其特征在于,所述超声激励系统包括计算机设备以及权利要求1-8中任意一项所述的超声激励装置;10. An ultrasonic excitation system, characterized in that the ultrasonic excitation system comprises computer equipment and the ultrasonic excitation device according to any one of claims 1-8; 所述计算机设备与所述超声激励装置通信连接,用于向所述超声激励装置发送各个通道的超声激励参数;The computer equipment is communicatively connected with the ultrasonic excitation device, and is used to send ultrasonic excitation parameters of each channel to the ultrasonic excitation device; 所述超声激励装置基于所述超声激励参数产生对应的超声波,并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备;The ultrasonic excitation device generates corresponding ultrasonic waves based on the ultrasonic excitation parameters, and sends the ultrasonic echo data to the computer equipment after collecting the ultrasonic echo data; 所述计算机设备根据所述超声回波数据进行超声成像后输出可视化图像。The computer device performs ultrasound imaging according to the ultrasound echo data and outputs a visualized image.
CN201711401737.4A 2017-12-22 2017-12-22 Device, method and system are motivated by ultrasound Pending CN108144199A (en)

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CN113801787A (en) * 2021-08-06 2021-12-17 深圳大学 Ultrasonic integrated micro-droplet array detection platform and preparation method and application thereof
CN113970597A (en) * 2020-07-22 2022-01-25 上海宝信软件股份有限公司 Logic type ultrasonic probe array system and method based on comparison and gating
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CN112754604B (en) * 2019-11-05 2022-02-01 重庆迈科唯医疗科技有限公司 Ultrasonic knife host, ultrasonic knife system and automatic matching method for impedance of transducer of ultrasonic knife system
CN112754604A (en) * 2019-11-05 2021-05-07 重庆迈科唯医疗科技有限公司 Ultrasonic knife host, ultrasonic knife system and automatic matching method for impedance of transducer of ultrasonic knife system
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CN113970597A (en) * 2020-07-22 2022-01-25 上海宝信软件股份有限公司 Logic type ultrasonic probe array system and method based on comparison and gating
CN113768581A (en) * 2021-07-30 2021-12-10 费兴伟 Multi-frequency ultrasonic generation system used in urinary system ultrasonic equipment
CN113801787A (en) * 2021-08-06 2021-12-17 深圳大学 Ultrasonic integrated micro-droplet array detection platform and preparation method and application thereof
CN114717267B (en) * 2022-04-15 2023-10-31 深圳高性能医疗器械国家研究院有限公司 Gene transfection method and system
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CN116590142B (en) * 2023-04-18 2025-01-14 广东省智能科学与技术研究院 Ultrasonic excitation method, device, system and storage medium

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Application publication date: 20180612