CN108142936A - A kind of marine organism type special medicine purposes formula food for tumor patient - Google Patents

Abstract

The invention belongs to the field of formula food for special medical use, and relates to a marine biological formula food for special medical purpose suitable for tumor patients and a preparation method thereof. In particular, lugworm is used as a protein source of enteral nutrition preparations. The mode of use can be directly administered through the gastrointestinal tract, and can also be taken orally. The marine organism type special medical formula food for tumor patients provided by the present invention is composed of the following nutritional components in percentage by weight: 20-30% protein, 5-10% fat, 70-75% carbohydrate, and 0.090 choline ～0.100%, inositol 15～20%, taurine 0.035～0.06%, and the balance is multivitamins and mineral elements with a mass ratio of 1:20～30; the 20‑60% protein comes from clam worms pink. Compared with the glutamine + arginine protein-sourced formula food group for special medical purposes, the clam worm formula food group provided by the present invention has a better nutritional support effect, and the clam worm protein accounts for 60% of the total protein of the preparation %, the nutritional efficacy is most significant.

Description

A marine biological special medical formula food for tumor patients

technical field

The invention belongs to the field of formula food for special medical use, and relates to a marine biological formula food for special medical purpose suitable for tumor patients and a preparation method thereof. In particular, lugworm is used as a protein source of enteral nutrition preparations. The mode of use can be directly administered through the gastrointestinal tract, and can also be taken orally.

Background technique

Malignant tumor is a common clinical disease, and it is also the main cause of threatening human health and causing death at present and for a long time to come. Cancer patients suffer from various degrees of malnutrition due to abnormal tumor growth and metabolism, pain, and obstruction. Based on the close relationship between immunity and nutrition, using reasonable nutritional support to improve the immune function of tumor patients has become the frontier direction of food research. At the same time, more and more attention has been paid to the application of enteral nutrition support in the adjuvant treatment of cancer and critically ill patients.

Studies have shown that enteral nutrition (Enteral nutrition, EN) can improve intestinal function, reduce endotoxin into the blood and release of inflammatory mediators in the body. Tumor-type enteral nutrition preparations are mainly used in critically ill patients before and after surgery and during radiotherapy and chemotherapy. At present, my country's enteral nutrition preparations are mainly imported from Europe. The raw materials used in the domestic marketed EN preparations are mainly terrestrial animals and plants and their extracts, and the protein sources are mainly soybean protein, milk protein, egg protein or hydrolyzed vegetable protein. and its derivatives. The development of safe and effective enteral nutrition preparations with new protein sources is also an important research content in the field of clinical EN preparations or formula foods for special medical purposes.

Nereist worm is a marine organism with the same source of medicine and food, and it is also a natural feed for fish and shrimp. The double-toothed clamworm has the effects of nourishing the spleen and stomach, nourishing blood and nourishing blood, promoting water and reducing swelling. It is rich in nutrients, the amino acid content accounts for 67.43% of the dry weight, the fatty acid content accounts for 14.24% of the dry weight, of which the EPA content is 6.53%, and it also contains Cu, Sn, Se, Hg, As, I, Zn and Cd, etc. trace elements. Active ingredients such as superoxide dismutase, fibrinolytic enzyme, plasminogen activator, and collagenase contained in clamworm have excellent anti-aging, anti-tumor, anti-inflammation, prevention of high blood pressure, and elimination of arteriosclerosis. The high proportion of arginine and glutamine in nereis protein can support the homeostasis of the immune system in critically ill patients by maintaining the functional integrity of immune cells. The omega-3 fatty acids contained in clamworm can effectively delay the inflammatory response and prevent free radical damage. We found in the research that the essential amino acid content of clamworms accounts for 47.21% of the total amino acids, and the ratio of essential amino acids to non-essential amino acids is 89%. The mode of content, the amino acid composition of protein with better quality is about 40% of essential amino acids/total amino acids, and more than 60% of essential amino acids/non-essential amino acids. The double-toothed clamworm is a high-quality raw material with broad development prospects.

In recent years, the indispensability of nutritional support in clinical tumor work has been increasingly recognized by professionals. Currently, the enteral nutrition preparations on the market are purely complete nutrients, and one or several "medicine and food homologous" ingredients added are only used as nutritional functional components. , a series of side effects such as reduced immunity, gastrointestinal dysfunction, bone marrow suppression, nausea, vomiting, hair loss, and mucosal damage caused by chemotherapy. The ratio is not entirely suitable for our residents. Therefore, it is of great significance to develop formula foods for special medical purposes used in cancer patients.

Contents of the invention

In view of the deficiency of the existing formula food for special medical use of tumor patients, one of the purposes of the present invention is to design and provide a kind of food that can improve the quality of life of tumor patients and supplement tumor The nutrition of patients, marine biological special medical nutritional formula food for patients with liver precancerous lesions that prolongs the survival time of tumor patients.

1. Determination of Nutrients in Nereis worm

To configure formula food for special medical purposes that meets the requirements of patients with precancerous liver lesions, the content of various substances in clam worms needs to be determined through experiments. The detection methods and experimental results are shown in Tables 1 and 2 below.

Table 1 Detection methods and standards of nutritional components of P. didentensis

Table 2 Analysis of nutritional components of P.

2. Proportion basis of substances in clam worm formula food for special medical purpose

The patented formula of the present invention is calculated strictly according to the requirements of full-nutrition formula food applicable to people over 10 years old in GB29922-2013 "General Rules for Formula Foods for Special Medical Purposes", as well as the special instructions on full-nutrition formula food for tumor patients in the appendix and relevant literature. See Table 3, Table 4 and Table 5 for details.

Table 3 Vitamin and mineral indicators (people over 10 years old)

Table 4 Optional component indicators (group over 10 years old)

Table 5 Complete nutritional formula food for cancer patients

3. Principles for determining the amount of main substances added to clam worm formula food for special medical purposes: calories ≧ 295KJ (70kcal)/100g

Protein≧0.8g/100KJ (3.5g/100kcal)

Energy supply ratio of linoleic acid≧2.0%

Special function ratio of tumor patients: protein: 15-20%; carbohydrate: 60-65%; fat: 15-20%.

formula:

(Total energy) KJ/100g=((carbohydrate) g×17KJ/g+(protein)g×17KJ/g+(fat)g×37KJ/g/100g=1816.85KJ

(Protein) g=(1816.85KJ×20%)/17KJ/g

(Fat) g=(1816.85KJ×14.54%)/37KJ/g

(carbohydrate) g=(1816.85KJ×65.45%)/17KJ/g

Calculate the content of each substance in the formula according to the above formula principles and formulas.

4. Determination of carbohydrates in clam worm formula food for special medical purposes

Carbohydrates were initially determined during the tableting process. Wu Zhiwei corn starch, maltodextrin, glucose, sucrose and microcrystalline cellulose were added, but after tableting experiments, many problems were found, such as the tablet was too soft to form, and the tablet was easily affected by moisture. , or the tablet is too hard, etc., but after several adjustments to determine the added substances and amounts of carbohydrates, and after adjustments and tablet compression experiments, it was finally determined that the added substances of carbohydrates in the formula are: maltodextrin, lactose , low substituted hydroxypropyl cellulose and microcrystalline cellulose. Among them, maltodextrin and lactose act as binders in the formula, low-substituted hydroxypropyl cellulose and microcrystalline cellulose act as disintegrating agents, and an appropriate amount of magnesium stearate is added as the formula Lubricant, finally pressed in addition to forming the clamworm special medical purpose formula food tablet.

In order to solve the above technical problems, the technical solution provided by the present invention is a marine biological special medical formula food for tumor patients, which is composed of the following nutritional ingredients in percentage by weight: protein 20-30%, fat 5-10% , 70-75% carbohydrates, 0.090-0.100% choline, 15-20% inositol, 0.035-0.06% taurine, and the balance is multivitamins and mineral elements with a mass ratio of 1:20-30; The above-mentioned 20-60% protein is derived from clam worm meal. Preferably, 60% of the protein comes from clam worm meal.

Wherein, the clam worm powder is prepared by the following method:

(A) clam worms washed with water are cleaned with aqueous citric acid solution;

(B) placing the clamworm in 10% saline solution for 2 hours;

(C) remove the lugworm of the coelenterate content and then move into the aqueous solution for cleaning;

(D) The clam worm after desalination is heated and dried at 60° C. for 30 minutes;

(E) Crushing the dried clamworm into clamworm powder. The pulverization method can be to use air separation type superfine pulverizer.

Wherein, the protein is provided in the form of clamworm protein, whey protein, arginine, L-glutamine, and L-leucine; the fat is provided in the form of clamworm fat, docosahexaenoic acid, eicosapenta Provided in the form of enoic acid, α-linolenic acid, and n-6 linoleic acid; provided in the form of nereistose, carbohydrates, lactose, maltodextrin, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose.

Wherein, the protein includes 4.0% to 12.5% of clamworm protein, 7.2% to 10.7% of whey protein, 0.42% to 2.9% of arginine, 0.42% to 2.9% of arginine, L-glutamine Amide 0.33% to 2.6%, L-leucine 0.27% to 0.58%.

Wherein, in percentage by weight of the total amount of the formula food, the fat includes 0.3% to 1.4% of nereis fat, 0.009% to 0.02% of docosahexaenoic acid, and 2.0% to 2.0% of eicosapentaenoic acid. 2.5%, α-linolenic acid 0.45% to 1.0%, n-6 linoleic acid 3.1% to 4.2%.

Wherein, the carbohydrates include 0.009% to 6.5% of nereisose, 10.7% to 17.2% of lactose, 4.2% to 14.3% of maltodextrin, microcrystalline cellulose 30.3%-32.5%, lentinan 0.0%-14.0%, low-substituted hydroxypropyl cellulose 6.17%-6.54%.

Wherein, in percentage by weight of the total amount of the formula food, the multivitamins include 0.14-1.0% of vitamin A, 0.0035-0.004‰ of vitamin B1, 0.0035-0.004‰ of vitamin B2, 0.0035-0.004‰ of vitamin B6, 0.0035-0.004‰ of vitamin C 0.095～0.0348‰, vitamin D 0.0000034～0.0000135‰, vitamin E 0.035～0.04‰, vitamin K 0.0001847～0.0001966‰, niacinamide 0.0088mg～0.01‰, folic acid 0.00093～0.00120‰0, pantothenic acid 0.08‰0‰0 and biotin 0.0123～0.04‰0 ~0.0001‰.

Wherein, the mineral elements include sodium 0.35-0.8%, potassium 0.47-1.0%, magnesium 0.03g-0.2%, molybdenum 0.00022-0.0022‰, zinc 0.0211-0.15‰ , manganese 2.10～0.0286‰, calcium 0.14～0.9%, copper 0.0025mg～0.0267‰, phosphorus 0.35～0.8% and chlorine 1.03～2.9%;

Wherein, the sodium mainly exists in the form of sodium chloride; the amount of the selected compound needs to be converted into the content of potassium element;

The potassium exists in the form of potassium chloride and potassium dihydrogen phosphate, and the amount of the selected compound needs to be converted into the content of potassium element;

The calcium exists in the form of calcium carbonate and calcium chloride, and the amount of the selected compound needs to be converted into the content of calcium element;

The phosphorus exists in the form of potassium dihydrogen phosphate, and the amount of the selected compound needs to be converted into the content of phosphorus element;

The magnesium exists in the form of magnesium chloride and magnesium stearate, and the amount of the selected compound needs to be converted into the content of magnesium element;

The zinc exists in the form of zinc lactate, and the amount of the selected compound needs to be converted into the content of zinc element;

The copper exists in the form of copper sulfate pentahydrate, and the amount of the selected compound needs to be converted into the content of copper element;

Described manganese exists in the form of manganese carbonate;

Described chloride exists in the form of sodium chloride, potassium chloride and calcium chloride;

The molybdenum exists in the form of sodium molybdate dihydrate;

The vitamin A is β-carotene.

Wherein, the special medical nutritional formula food for tumor patients is powder or granule.

The above, including the following steps:

(1) The raw materials are weighed and pulverized;

(2) Evenly mix clamworm powder with docosahexaenoic acid, eicosapentaenoic acid, α-linolenic acid, and linoleic acid, pass through a 40-mesh sieve, and set aside;

(3) Evenly mix lactose, maltodextrin, microcrystalline cellulose, lentinan, and low-substituted hydroxypropyl cellulose, pass through a 40-mesh sieve, and set aside;

(4) The remaining vitamins, amino acids, taurine and inorganic salts are evenly mixed, and cross a 40-mesh sieve.

spare;

(5) uniformly mixing the materials obtained in the above steps (2), (3) and (4);

(6) The materials obtained in step (5) are inspected and qualified, and then directly filled into cans, or compressed into tablets, and finally irradiated and sterilized for preservation.

Compared with the prior art, the present invention has the following beneficial effects:

1) This product contains the five major nutrients needed by the human body, and is rich in choline, inositol, and taurine, making the nutrition more balanced.

2) L-glutamine, arginine and L-leucine are added as special nutrients to this kind of formula food for special medical purposes. By giving nutrients that can regulate immunity, the nutritional status of the body can be improved and the body can be enhanced. The role of the body's immune function.

3) Add omega-3 fatty acids (essential fatty acids), in which docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can inhibit tumor occurrence, growth and metastasis speed; The activity of inflammatory factors can improve human innate immunity and enhance the oxidation activity of low-density lipoprotein in vivo, which plays a certain role in preventing inflammation and autoimmunity.

4) Pioneering the use of clam worms as one of the sources of protein, fat, and carbohydrates. As a high-quality protein source, the application of clam worm protein in marine biological special medical formula food suitable for tumor patients not only broadens the utilization rate of marine resources, but also provides a new source of additives for clam worm or other marine organisms in the future. The use of special food for enteral nutrition in special populations provides valuable reference value.

5) Strictly adjust the composition and ratio according to the nutritional and metabolic needs of tumor patients, and optimize the three major nutrients to the best ratio, which is more targeted and more effective.

6) The above-mentioned marine biological special medical formula food suitable for cancer patients uses marine biological food ingredients as one of the sources of complete nutritional formula, synergizes among the components, reasonably supplements comprehensive nutrition and sufficient energy, and can Improve the nutritional metabolism of mice with precancerous lesions of the liver, inhibit liver damage, reduce inflammatory reactions, improve therapeutic effects, and enhance body immunity, and when the protein of C. It filled the blank of domestic marine biological EN preparations. It has very important social value, its preparation method is simple, and it is suitable for the application of large-scale industrial production.

Description of drawings

The body weight change (g) in January before and after the injection of each group of mice in Fig. 1; Figure A represents embodiment 1, B represents embodiment 2, C represents embodiment 3, D represents positive control group, E blank group, F control group.

Figure 2 Morphological slices of liver tissue in mice with precancerous liver lesions in each group, the black circle area indicates obvious inflammatory infiltration.

Detailed ways

The following part is a specific implementation to further explain the present invention, but the following implementation is only a further explanation of the present invention, and does not mean that the protection scope of the present invention is limited to this, and all equivalent replacements based on the ideas of the present invention are included in this document. protection scope of the invention.

Example 1

This example relates to marine biological special medical formula food for cancer patients, the specific formula is shown in Table 1 below; wherein, the protein contains 12.36g of nereis protein, 7.21g of whey protein, 0.44g of arginine, L- Glutamine 0.32g and L-leucine 0.26g, fat contains nereis fat 1.24g, α-linolenic acid 0.53g and linoleic acid 3.15g, docosahexaenoic acid (DHA) 0.009g and di Eicosapentaenoic acid (EPA) 2.29g, carbohydrates include 1.80g claripolysaccharide, 6.21g low-substituted hydroxypropyl cellulose, 15.14g lactose, 13.20g maltodextrin and 30.81g microcrystalline cellulose.

During preparation, solid raw materials: clam worm powder, arginine, L-glutamine, L-leucine, whey protein, α-linolenic acid, docosahexaenoic acid (DHA), eicosa Pentaenoic acid (EPA), linoleic acid, low-substituted hydroxypropyl cellulose, lactose, maltodextrin, microcrystalline cellulose, complex minerals, and multivitamins are weighed in proportion, and mixed in a dry mixer for 1 hour Sieve until the particle size is about 0.8mm. Filling is performed under aseptic conditions.

Table 1

unit per 100g unit per 100g protein gram 20.59 minerals Fat gram 7.22 sodium gram 0.35 carbohydrate gram 67.16 Potassium gram 0.75 Vitamin A gram 0.0148 magnesium gram 0.078 Vitamin D mg 0.013 molybdenum mg 0.026 Vitamin C gram 0.3482 zinc mg 1.52 Vitamin K mg 0.0185 manganese mg 2.11 Vitamin E mg 3.52 calcium gram 0.229 Vitamin B1 mg 0.35 copper mg 2.46 Vitamin B2 mg 0.35 phosphorus mg 0.229 Vitamin B6 mg 0.35 chlorine gram 0.125 folic acid mg 0.0933 pantothenic acid mg 1.232 biotin mg 0.0088 Nicotinamide mg 0.88 choline mg 93.31 Inositol mg 17.61 taurine mg 44.01

Example 2

This example relates to marine biological special medical formula food for cancer patients. The specific formula is shown in Table 1 below; wherein, the protein contains 8.24g of nereis protein, 7.25g of whey protein, 2.11g of arginine, L- Glutamine 2.46g and L-leucine 0.53g, fat contains nereis fat 0.83g, α-linolenic acid 0.53g and linoleic acid 3.57g, docosahexaenoic acid (DHA) 0.018g and di Eicosapentaenoic acid (EPA) 2.27g, carbohydrates containing clam polysaccharide 1.2g, low-substituted hydroxypropyl cellulose 6.21g, lactose 15.40g, maltodextrin 13.54g and microcrystalline cellulose 30.81g.

During preparation, the solid raw materials: clam worm powder, arginine, L-glutamine, L-leucine, whey protein, α-linolenic acid, docosahexaenoic acid (DHA), eicosa Pentaenoic acid (EPA), linoleic acid, low-substituted hydroxypropyl cellulose, lactose, maltodextrin, microcrystalline cellulose, complex minerals, and multivitamins are weighed in proportion, and mixed in a dry mixer for 1 hour Sieve until the particle size is about 0.8mm. Filling is performed under aseptic conditions.

Table 2

unit per 100g unit per 100g protein gram 20.06 minerals Fat gram 7.22 sodium gram 0.35 carbohydrate gram 67.16 Potassium gram 0.75 Vitamin A gram 0.0148 magnesium gram 0.078 Vitamin D mg 0.013 molybdenum mg 0.026 Vitamin C gram 0.3482 zinc mg 1.52 Vitamin K mg 0.0185 manganese mg 2.11 Vitamin E mg 3.52 calcium gram 0.229 Vitamin B1 mg 0.35 copper mg 2.46 Vitamin B2 mg 0.35 phosphorus mg 0.229 Vitamin B6 mg 0.35 chlorine gram 0.125 folic acid mg 0.0933 pantothenic acid mg 1.232 biotin mg 0.0088 Nicotinamide mg 0.88 choline mg 93.31 Inositol mg 17.61 taurine mg 44.01

Example 3

This example relates to marine biological special medical formula food for cancer patients. The specific formula is shown in Table 1 below; wherein, the protein contains 4.12g of clamworm protein, 10.12g of whey protein, 2.73g of arginine, L- Glutamine 3.08g and L-leucine 0.55g, fat contains nereis fat 0.41g, α-linolenic acid 0.53g and linoleic acid 3.99g, docosahexaenoic acid (DHA) 0.026g and di Eicosapentaenoic acid (EPA) 2.26g, carbohydrates containing clam polysaccharide 0.60g, low-substituted hydroxypropyl cellulose 6.22g, lactose 16.29g, maltodextrin 13.26g and microcrystalline cellulose 30.81g.

During preparation, the solid raw materials: clam worm powder, arginine, L-glutamine, L-leucine, whey protein, α-linolenic acid, docosahexaenoic acid (DHA), eicosa Pentaenoic acid (EPA), linoleic acid, low-substituted hydroxypropyl cellulose, lactose, maltodextrin, microcrystalline cellulose, complex minerals, and multivitamins are weighed in proportion, and mixed in a dry mixer for 1 hour Sieve until the particle size is about 0.8mm. Filling is performed under aseptic conditions.

table 3

unit per 100g unit per 100g protein gram 20.60 minerals Fat gram 7.22 sodium gram 0.35 carbohydrate gram 67.18 Potassium gram 0.75 Vitamin A gram 0.0148 magnesium gram 0.078 Vitamin D mg 0.013 molybdenum mg 0.026 Vitamin C gram 0.3482 zinc mg 1.52 Vitamin K mg 0.0185 manganese mg 2.11 Vitamin E mg 3.52 calcium gram 0.229 Vitamin B1 mg 0.35 copper mg 2.46 Vitamin B2 mg 0.35 phosphorus mg 0.229 Vitamin B6 mg 0.35 chlorine gram 0.125 folic acid mg 0.0933 pantothenic acid mg 1.232 biotin mg 0.0088 Nicotinamide mg 0.88 choline mg 93.31 Inositol mg 17.61 taurine mg 44.01

The above-mentioned components are combined in a specific ratio to synergize with each other, reasonably supplement comprehensive nutrition and sufficient energy, and relieve the symptoms of nutritional metabolism caused by anorexia, nutritional deficiency, and weight loss in patients with precancerous liver lesions. Specifically reflected in the following test experiments:

The formula food obtained in Examples 1-3 of the present invention was tested, and they were respectively set as Nereis worm treatment group 1 (A 60% bidentate pericymbin protein/total protein w/w), nereis treatment group 2 (B 40% bidentate Nereis protein/total protein w/w) and Nereis worm treatment group 3 (C 20% bidentate nereis protein/total protein w/w) were simultaneously set up as a positive control group (D glutamine + arginine protein source Formula food group for special medical purposes), blank group (E) and control group (F), the groups are shown in Table 4.

Table 4: Table of Treatment of Each Group

Note: a The weight of Neris bidenta EN preparation is 1.0 g per tablet; b The weight of Lishikang EN preparation is 1.1 g per tablet.

The mice in groups A, B, C, D, and E were intraperitoneally injected with 1% DEN solution at 0.1ml/10g, 1/w, for 4w consecutively, to establish mouse tumor models with early liver precancerous lesions.

12 hours from the first injection, groups A, B, and C were given enteral nutrition preparations (2 tablets/piece/d) with different degrees of substitution at 1320.06 kJ/kg/d, and group D was given the same caloric Glutamine + arginine protein source formula food group for special medical purposes (2 tablets/piece/d). Group E and Group F were given the same caloric feed.

Weigh the mice twice a week from the first day of injection and feeding, fast for 12 hours at the end of the fourth week, take the liver, make histopathological sections, and observe the morphology of the liver tissue under an optical microscope (10×40 times) Variety. Therefore, the effectiveness and feasibility of the marine biotype formula food as nutritional formula food for special medical purposes of tumor patients were evaluated.

The experimental results are shown in Figures 1 and 2. It can be seen that the nutritional formula food for special medical use for tumor patients described in Examples 1-3 can supplement the nutrition of patients with early liver precancerous lesions and increase the weight of mice. The results of histological sections showed that the degeneration and nuclear atypia of liver cells in the clam worm group were alleviated, and the infiltration of macrophages was reduced.

Based on all the above experimental results, we can generally see that the clam worm formula food for special medical purpose group has a better nutritional support effect than the glutamine + arginine protein source formula food for special medical purpose group, and both When the clam worm protein accounts for 60% of the total protein of the preparation, the nutritional effect is the most significant. Therefore, we have reason to prove that clamworm special medical purpose formula food is effective in nutritional support for patients with precancerous liver lesions.

In this experiment, nereist protein, nereist polysaccharide, and nereist fat were added in the form of nereist powder, and were not extracted and purchased independently.

Claims (10)

1. A kind of 1. marine organism type special medicine purposes formula food for tumor patient, which is characterized in that percentage by weight Than being made of following nutritional ingredient：Protein 20~30%, fat 5~10%, carbohydrate 70~75%, choline 0.090 ~0.100%, inositol 15~20%, taurine 0.035~0.06%, surplus is that mass ratio is 1:20~30 multi-vitamins And mineral matter element；The 20-60% protein derives from clam worm powder.
2. 2. formula food according to claim 1, which is characterized in that the clam worm powder is prepared by following methods：

   (A) clam worm being rinsed with water is cleaned with aqueous citric acid solution；

   (B) clam worm is placed in 10% common salt aqueous solution 2 hours；

   (C) clam worm for removing coelenteron content moves into aqueous cleaning again；

   (D) at 60 DEG C, the time is thermally dried the clam worm after desalination for 30min；

   (E) dried clam worm is ground into clam worm powder.
3. 3. formula food according to claim 1, which is characterized in that the protein include clam worm albumen, lactalbumin, Arginine, L-Glutamine, L-Leu form provide；Fat is with clam worm fat, docosahexaenoic acid, eicosapentaenoic Acid, alpha-linolenic acid, n-6 linoleic acid form provide；Clam worm sugar, carbohydrate are with clam worm, lactose, maltodextrin, microcrystalline cellulose Element, low-substituted hydroxypropyl cellulose form provide.
4. 4. formula food according to claim 1, which is characterized in that account for the weight percent of the formula food total amount Than, the protein include clam worm albumen 4.0%~12.5%, lactalbumin 7.2%~10.7%, arginine 0.42%~ 2.9%th, L-Glutamine 0.33%~2.6%, L-Leu 0.27%~0.58%.
5. 5. formula food according to claim 1, which is characterized in that account for the weight percent of the formula food total amount Than the fat includes clam worm fat 0.3%~1.4%, docosahexaenoic acid 0.009%~0.02%, 20 light dydrocarbons Olefin(e) acid 2.0%~2.5%, alpha-linolenic acid 0.45%~1.0%, n-6 linoleic acid 3.1%~4.2%.
6. 6. formula food according to claim 3, which is characterized in that account for the weight percent of the formula food total amount Than the carbohydrate includes clam worm sugar 0.009%~6.5%, lactose 10.7%~17.2%, maltodextrin 4.2% ~14.3%, microcrystalline cellulose 30.3%~32.5%, lentinan 0.0%~14.0%, low-substituted hydroxypropyl cellulose 6.17%~6.54%.
7. 7. formula food according to claim 1, which is characterized in that account for the weight percent of the formula food total amount Than the multi-vitamins include vitamin A 0.14~1.0%, vitamin B1 0.0035~0.004 ‰, vitamin B2 0.0035~0.004 ‰, vitamin B6 0.0035~0.004 ‰, vitamin C 0.095~0.0348 ‰, vitamin D 0.0000034~0.0000135 ‰, vitamin E 0.035~0.04 ‰, vitamin K 0.0001847~0.0001966 ‰, Niacinamide 0.0088mg~0.01 ‰, folic acid 0.00093~0.0012 ‰, pantothenic acid 0.0123~0.04 ‰ and biotin 0.0000880~0.0001 ‰.
8. 8. formula food according to claim 1, which is characterized in that account for the weight percent of the formula food total amount Than, the mineral matter element include sodium 0.35~0.8%, potassium 0.47~1.0%, magnesium 0.03g~0.2%, molybdenum 0.00022~ 0.0022 ‰, zinc 0.0211~0.15 ‰, manganese 2.10~0.0286 ‰, calcium 0.14~0.9%, copper 0.0025mg~ 0.0267 ‰, phosphorus 0.35~0.8% and chlorine 1.03~2.9%.
9. 9. formula food according to claim 8, it is characterised in that：The sodium mainly exists in the form of sodium chloride, The used in amounts of selected compounds is converted into the content of sodium element；

   The potassium is existed in the form of potassium chloride and potassium dihydrogen phosphate, and the used in amounts of selected compounds is converted into potassium element Content；

   The calcium is existed in the form of calcium carbonate and calcium chloride, and the used in amounts of selected compounds is converted into containing for calcium constituent Amount；

   The phosphorus is existed in the form of potassium dihydrogen phosphate, and the used in amounts of selected compounds is converted into the content of P elements；

   The magnesium is existed in the form of magnesium chloride and magnesium stearate, and the used in amounts of selected compounds is converted into containing for magnesium elements Amount；

   The zinc is existed in the form of zinc lactate, and the used in amounts of selected compounds is converted into the content of Zn-ef ficiency；

   The copper is existed in the form of cupric sulfate pentahydrate, and the used in amounts of selected compounds is converted into the content of copper；

   The manganese is existed in the form of manganese carbonate；

   The chloride is existed in the form of sodium chloride, potassium chloride and calcium chloride；

   The molybdenum is existed in the form of Sodium Molybdate Dihydrate；

   The vitamin A is beta carotene.
10. 10. the preparation method of formula food according to claim 9, which is characterized in that include the following steps：

    (1) raw material is weighed, and is crushed；

    (2) clam worm powder and docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, linoleic acid are uniformly mixed, crosses 40 mesh Sieve, it is spare；

    (3) lactose, maltodextrin, microcrystalline cellulose, lentinan, low-substituted hydroxypropyl cellulose are uniformly mixed, crosses 40 mesh Sieve, it is spare；

    (4) remaining vitamins, amino acid, taurine and inorganic salts are uniformly mixed, cross 40 mesh sieve,

    It is spare；

    (5) material that above-mentioned steps (2), (3) and (4) obtain uniformly is mixed；

    (6) material for obtaining step (5) direct tinning or progress tabletting after the assay was approved, last radiation sterilizing preservation.