CN108132355B - Medical instrument, reagent needle scheduling method and device - Google Patents
Medical instrument, reagent needle scheduling method and device Download PDFInfo
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- CN108132355B CN108132355B CN201711392842.6A CN201711392842A CN108132355B CN 108132355 B CN108132355 B CN 108132355B CN 201711392842 A CN201711392842 A CN 201711392842A CN 108132355 B CN108132355 B CN 108132355B
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 187
- 238000000034 method Methods 0.000 title claims abstract description 51
- 239000000523 sample Substances 0.000 claims abstract description 175
- 238000006243 chemical reaction Methods 0.000 claims abstract description 91
- 239000012470 diluted sample Substances 0.000 claims abstract description 20
- 239000012895 dilution Substances 0.000 claims abstract description 18
- 238000010790 dilution Methods 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 238000000926 separation method Methods 0.000 claims abstract description 3
- 238000005070 sampling Methods 0.000 claims description 31
- 239000003085 diluting agent Substances 0.000 claims description 14
- 238000007865 diluting Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- 239000012898 sample dilution Substances 0.000 claims description 4
- 238000003018 immunoassay Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 abstract description 10
- 230000004907 flux Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 description 26
- 230000008569 process Effects 0.000 description 22
- 238000010586 diagram Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010517 secondary reaction Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
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- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to a reagent needle scheduling method, which comprises the following steps: 1) judging whether a sample needs to be added into the reaction bin, if so, entering the step 2), otherwise, judging whether the sample needs to be diluted, if so, entering the step 3), otherwise, judging whether the sample needs to be diluted in a cup, and if so, entering the step 4); 2) adding the reagent sucked by the reagent needle into the corresponding sample, and returning to the step 1); 3) the reagent needle absorbs the dilution liquid and uniformly mixes the dilution liquid with the corresponding sample, and the step 1) is returned; 4) and (4) the reagent needle performs cup separation on the diluted sample, and the step 1) is returned. According to the optimized reagent needle scheduling method, the time for the sample to wait for the secondary reagent adding is obviously shortened, and the sample testing efficiency and the instrument flux are obviously improved. The invention also relates to a reagent needle scheduling device and a medical instrument.
Description
Technical Field
The invention relates to the technical field of detection, in particular to a medical instrument, a reagent needle scheduling method and a reagent needle scheduling device.
Background
The automatic analyzer has wide application in the medical and chemical fields, has a great variety, and can automatically perform qualitative or quantitative detection on various components of a sample.
In the process of detecting a sample by using an automatic analyzer, it is generally necessary to add a first reagent, a second reagent, and the like in sequence after the sample is added until all the required reagents are added. However, some special samples have too high concentration, so the amount of reagent added in the reaction process is relatively large, which increases the consumption of the reagent for detection and has no practical value.
At present, the general method is to dilute a high-concentration sample, firstly dilute the sample in a certain proportion, and then normally test the diluted sample, so that the accuracy of the result is ensured, and the consumption of the reagent is reduced to a great extent.
In the current sample dilution process, a series of processes of adding samples, adding a diluent, diluting samples, dividing cups, diluting samples and adding reagents are classified into a sample processing process, wherein the sample processing process is mainly completed by a reagent needle, and once the sample processing process is started, the whole sample processing process needs to be completed. However, in the actual testing process, the diluting liquid and the diluted sample are both relatively time-consuming instrument actions, a "sample processing" process takes approximately 20 seconds, in this relatively long time, the reagent needle is completely occupied by the "sample processing" process, in this period of "sample processing" time, once a reaction sample needing to be subjected to secondary reagent adding occurs, there is a possibility that a secondary reaction reagent cannot be obtained for a long time, the testing progress of the sample is delayed, the throughput of the whole instrument equipment is greatly influenced, and this is more prominent in the medical instrument with a single reagent needle.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides a reagent needle scheduling method, so as to optimize the actions of a reagent needle, reduce the time for a sample to wait for a second reagent addition, and improve the sample testing efficiency and the sample testing throughput of a testing apparatus.
A second aspect of the present invention is to provide a reagent needle scheduling apparatus capable of implementing the reagent needle scheduling method;
a third aspect of the present invention is to provide a medical instrument capable of performing the above reagent needle scheduling method.
The reagent needle scheduling method disclosed by the invention comprises the following steps:
1) judging whether a sample needs to be added into the reaction bin, if so, entering the step 2), otherwise, judging whether the sample needs to be diluted, if so, entering the step 3), otherwise, judging whether the sample needs to be diluted in a cup, and if so, entering the step 4);
2) adding the reagent sucked by the reagent needle into the corresponding sample, and returning to the step 1);
3) the reagent needle absorbs the dilution liquid and uniformly mixes the dilution liquid with the corresponding sample, and the step 1) is returned;
4) and (4) the reagent needle performs cup separation on the diluted sample, and the step 1) is returned.
Preferably, the step 4) specifically includes: the reaction bin prepares clean reaction cups according to the quantity of the required cups, and the reagent needle sucks and dilutes the sample and distributes the sample into the reaction cups.
Preferably, the reagent needle scheduling method further includes, before the step 1):
B) preparing a clean reaction cup in the reaction bin;
C) and (3) sucking a sample at the sampling position by using the reagent needle, adding the sample into the reaction cup in the reaction bin, and then entering the step 1).
Preferably, the reagent needle scheduling method further includes, before the step B):
A) and C, judging whether the sampling position has a sample to be detected, if so, entering the step B), and if not, ending the step.
Preferably, in the reagent needle scheduling method, in the step 1), when the sample is not diluted for dispensing, the procedure returns to the step a).
The reagent needle scheduling apparatus disclosed in the present invention includes:
the first judgment module is used for judging whether a sample in the reaction bin needs to be added with a reagent;
the reagent adding control module is used for controlling a reagent needle to suck a reagent to add the reagent into a corresponding sample when the sample in the reaction bin needs to be added with the reagent;
the sample dilution control module is used for controlling a reagent needle to absorb diluent and uniformly mix the diluent into a corresponding sample when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement;
and the cup dividing control module controls the reagent needle to divide the diluted sample into cups when the sample in the reaction bin has no reagent adding and diluting requirements and the diluted sample has the cup dividing requirement.
Preferably, the reagent needle scheduling device further includes:
the second judgment module is used for judging whether the sampling position has a sample to be detected or not;
and the sample adding module controls the reaction bin to prepare a clean reaction cup when a sample to be detected exists in the sampling position, controls the reagent needle to absorb the sample at the sampling position, and adds the sample into the reaction cup in the reaction bin.
The medical instrument disclosed by the invention comprises a reaction bin, a reagent needle and a reagent needle scheduling device for controlling the action of the reagent needle, wherein if a sample in the reaction bin has a requirement for adding a reagent, the reagent needle scheduling device controls the reagent needle to suck the reagent and add the reagent into the corresponding sample; when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement, the reagent needle scheduling device controls the reagent needle to absorb the dilution liquid and uniformly mix the dilution liquid into the corresponding sample; when the sample in the reaction bin has no reagent adding and diluting requirements and the diluted sample needs to be separated, the reagent needle scheduling device controls the reagent needle to separate the diluted sample.
Preferably, the medical apparatus further comprises a sampling position, when a sample is to be measured at the sampling position, the reaction chamber is prepared with a clean reaction cup, and the reagent needle scheduling control device controls the reagent needle to suck the sample at the sampling position and add the sample into the reaction cup in the reaction chamber.
Preferably, the medical instrument is a chemiluminescent immunoassay analyzer.
It can be seen that in the reagent needle scheduling method disclosed in the present invention, the steps of the "sample processing" process in the prior art are decomposed, before the "sample processing" is performed, it is first determined whether a sample needs to be added to the reaction chamber, if so, the reagent is added in time, so that the sample reaction is performed in time; if the sample in the reaction chamber does not need to be added with the reagent, the process of 'sample processing' is started, and even if the process of 'sample processing' is in the process of 'sample processing', whether the sample in the reaction chamber needs to be added with the reagent is judged before the next flow, so that the waiting time of adding the reagent into the sample is shortened. By adopting the optimized reagent needle scheduling method, the time for the sample to wait for the secondary reagent addition is obviously shortened, and the sample testing efficiency and the instrument flux are obviously improved.
Drawings
FIG. 1 is a schematic flow chart illustrating a reagent needle scheduling method according to an embodiment of the present invention;
FIG. 2 is a timing diagram illustrating sample processing according to the prior art;
FIG. 3 is a timing diagram illustrating sample processing according to an embodiment of the present invention.
Detailed Description
The scheme disclosed by the invention is particularly suitable for the case that the reagent needle is used in a medical instrument for sucking a reagent and a sample, namely the reagent needle and the sample needle are shared. Prior to the present invention, technicians have found that once "sample processing" is required, the reagent needle is fully occupied by the "sample processing" process for that period of time, and other samples, if added, can only wait for the "sample processing" process to be completed, and for this reason, the technician has tried to replace the stepper motor with a faster response speed in order to bring the reagent arm and the reagent needle into motion more quickly, which is not only costly, but also not practical.
The inventor skillfully optimizes the scheduling mode of the reagent taking needle, so that the waiting time for adding the reagent for the second time to the sample is greatly shortened on the premise of not increasing the equipment parts and the equipment cost basically, and the sample detection efficiency is obviously improved.
The reagent needle scheduling method disclosed in the present invention will be described in detail below with reference to the accompanying drawings.
Referring to fig. 1, a reaction chamber is a region where a sample is added with a reagent or "sample processing" is performed, and in the reagent needle scheduling method disclosed in the present invention, when a reagent needle is located in the reaction chamber, the following steps are performed:
s1) judging whether the reaction bin has a sample needing to be added with the reagent, if so, entering the step S2), and if not, entering the step S11);
s11) judging whether the reaction bin has a sample needing to be diluted, if so, entering the step S3), and if not, entering the step S12);
s12): judging whether the reaction bin has a diluted sample needing to be separated, and if so, entering the step S4);
s2) the reagent needle adds a reagent to the sample, the reagent needle aspirates the reagent and adds it to the corresponding sample, and then returns to step S1);
s3) adding a reagent needle to the sample, sucking the diluent liquid (diluent) by the reagent needle, uniformly mixing the diluent liquid (diluent) into the corresponding sample, and returning to the step S1);
s4) the reagent needle cups the diluted sample, and returns to step S1).
In step S4), the diluted sample is a sample to which a diluent has been added.
It can be seen that, in the reagent needle scheduling method disclosed in the above embodiment, the steps of the "sample processing" process in the prior art are decomposed, before the "sample processing" is performed, it is first determined whether a sample needs to be added to the reaction chamber, and if so, the reagent is added in time, so that the sample reaction is performed in time; if the sample in the reaction chamber does not need to be added with the reagent, the process of 'sample processing' is started, and even if the process of 'sample processing' is in the process of 'sample processing', whether the sample in the reaction chamber needs to be added with the reagent is judged before the next flow, so that the waiting time of adding the reagent into the sample is shortened. By adopting the optimized reagent needle scheduling method, the time for the sample to wait for the secondary reagent addition is obviously shortened, and the sample testing efficiency and the instrument flux are obviously improved.
More specifically, please refer to fig. 2 and fig. 3 at the same time, fig. 2 is a schematic timing diagram of a sample processing in the prior art, and fig. 3 is a schematic timing diagram of a sample processing in the embodiment of the present invention, in both of the two schematic diagrams, the sample B needs to be "sample processed", and the rest of the samples do not need to be "sample processed", and it can be seen from comparison of the schematic timing diagrams that, in the sample requiring secondary reagent addition after optimization, the waiting time of the secondary reagent addition is greatly shortened, and the sample processing efficiency is significantly improved.
As shown in fig. 1, step S4) is to cup the diluted sample through the reagent needle, and the specific process is as follows: the reaction bin prepares clean reaction cups according to the number of the required cups, and then the reagent needle sucks the sample which is diluted completely and distributes the sample into each clean reaction cup.
In general, a sampling position is further provided in the medical instrument, the sampling position may be located on the track, of course, a sample bin may also be added, the sampling position is designed in the sample bin, after the sample to be tested enters the sampling position, the medical instrument may automatically sample and place the sample in a reaction cup in the reaction bin, in this embodiment, the sampling process also adopts an automatic manner, and specifically, before step S1), the method further includes the steps of:
s6) preparing a clean reaction cup in the reaction bin;
s7) sucking a sample into the reaction cup by the reagent needle, sucking the sample at the sampling position by the reagent needle, adding the sample into the prepared reaction cup in the reaction bin by moving the reagent arm, and then entering the step 1).
Further, in this embodiment, before the step S6), the method further includes the steps of:
s5) judging whether the sampling position has a sample to be tested, if so, entering the step S6), otherwise, ending.
As shown in fig. 1, after the addition of step S5), ineffective aspiration by the reagent needle can be effectively prevented.
It is easily understood by those skilled in the art that if there is no sample in the reaction chamber to add reagent and no sample to be processed, it means that it needs to be re-tested whether there is a new sample to be processed, for this reason, in step S12), when there is no diluted sample to be separated, it returns to step S5), when there is a new sample to be processed, it goes to step S6), and if there is no new sample to be processed, it ends.
In addition, the present invention also discloses a reagent needle scheduling device, comprising:
the first judgment module is used for judging whether a sample in the reaction bin needs to be added with a reagent;
the reagent adding control module is used for controlling a reagent needle to suck a reagent and add the reagent into a corresponding sample when the sample of the reaction bin needs to be added with the reagent;
the sample dilution control module is used for controlling a reagent needle to absorb diluent and uniformly mix the diluent into a corresponding sample when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement;
the cup separating control module is used for controlling the reagent needle to separate the diluted sample when the sample in the reaction bin does not have the additive reagent and the dilution requirement and the diluted sample has the cup separating requirement.
It is easy to find that the reagent needle scheduling device can control the reagent needle to operate the reagent needle scheduling method disclosed in the above embodiment, thereby achieving the purpose of shortening the time for the sample to wait for the second reagent addition and improving the sample detection efficiency.
Further, in order to detect whether a sample to be detected exists at the sampling position and realize automatic sample adding under the condition that the sample to be detected exists, the reagent needle scheduling device disclosed in this embodiment further includes a second judgment module and a sample adding module, wherein the second judgment module is used for judging whether the sample to be detected exists at the sampling position; when a sample to be detected exists in the sampling position, the reaction bin prepares a clean reaction cup, the sample adding module controls the reagent needle to absorb the sample positioned in the sampling position, and the sample is added into the reaction cup in the reaction bin.
The embodiment of the invention also discloses a medical instrument which comprises a reaction bin, a reagent needle and a reagent needle scheduling device for controlling the action of the reagent needle, wherein if a sample in the reaction bin has a requirement for adding a reagent, the reagent needle scheduling device controls the reagent needle to suck the reagent and add the reagent into the corresponding sample; when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement, the reagent needle scheduling device controls the reagent needle to absorb the diluent and uniformly mix the diluent into the corresponding sample; when the sample in the reaction bin has no reagent added or dilution requirement and has the requirement of diluting the sample cup, the reagent needle scheduling device controls the reagent needle to dilute the sample cup.
The medical instrument comprises but is not limited to a chemiluminescence immunoassay analyzer commonly used in the medical field, and the medical instrument further comprises a sampling position, when a sample is to be measured at the sampling position, a reaction chamber is prepared into a clean reaction cup, a reagent needle scheduling device controls a reagent needle to suck the sample at the sampling position, and the sample is added into the reaction cup in the reaction chamber, so that the sampling process is completed.
The reagent needle in the medical instrument adopts the optimized reagent needle scheduling method in the embodiment, so that the medical instrument has the advantage of high testing efficiency, and the method is not repeated herein.
The medical instrument, the reagent needle scheduling method and the reagent needle scheduling apparatus disclosed in the present invention are described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (7)
1. A reagent needle scheduling method, comprising:
A) judging whether the sampling position has a sample to be detected, if so, entering the step B), and if not, ending;
B) preparing a clean reaction cup in the reaction bin;
C) sucking a sample at a sampling position by a reagent needle, adding the sample into the reaction cup in the reaction bin, and then entering the step 1);
1) judging whether a sample needs to be added into the reaction bin, if so, entering the step 2), otherwise, judging whether the sample needs to be diluted, if so, entering the step 3), otherwise, judging whether the sample needs to be diluted in a cup, if so, entering the step 4), otherwise, returning to the step A);
2) adding the reagent sucked by the reagent needle into the corresponding sample, and returning to the step 1);
3) the reagent needle absorbs the dilution liquid and uniformly mixes the dilution liquid with the corresponding sample, and the step 1) is returned;
4) and (4) the reagent needle performs cup separation on the diluted sample, and the step 1) is returned.
2. The reagent needle scheduling method according to claim 1, wherein the step 4) specifically includes: the reaction bin prepares clean reaction cups according to the quantity of the required cups, and the reagent needle sucks and dilutes the sample and distributes the sample into the reaction cups.
3. A reagent needle scheduling apparatus, comprising:
the first judgment module is used for judging whether a sample in the reaction bin needs to be added with a reagent;
the reagent adding control module is used for controlling a reagent needle to suck a reagent to add the reagent into a corresponding sample when the sample in the reaction bin needs to be added with the reagent;
the sample dilution control module is used for controlling a reagent needle to absorb diluent and uniformly mix the diluent into a corresponding sample when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement;
and the cup dividing control module controls the reagent needle to divide the diluted sample into cups when the sample in the reaction bin has no reagent adding and diluting requirements and the diluted sample has the cup dividing requirement.
4. The reagent needle scheduling device according to claim 3, further comprising:
the second judgment module is used for judging whether the sampling position has a sample to be detected or not;
and the sample adding module is used for preparing a clean reaction cup in the reaction bin when a sample to be detected exists in the sampling position, controlling the reagent needle to absorb the sample in the sampling position and adding the sample into the reaction cup in the reaction bin.
5. A medical instrument comprises a reaction chamber, a reagent needle and a reagent needle scheduling device for controlling the action of the reagent needle, and is characterized in that if a sample in the reaction chamber has a demand for adding a reagent, the reagent needle scheduling device controls the reagent needle to suck the reagent and add the reagent into the corresponding sample; when the sample in the reaction bin has no reagent adding requirement and has a dilution requirement, the reagent needle scheduling device controls the reagent needle to absorb the dilution liquid and uniformly mix the dilution liquid into the corresponding sample; when the sample in the reaction bin has no reagent adding and diluting requirements and the diluted sample needs to be separated, the reagent needle scheduling device controls the reagent needle to separate the diluted sample.
6. The medical instrument of claim 5, further comprising a sampling site, wherein when a sample is to be measured at the sampling site, the reaction chamber is prepared for a clean reaction cup, and the reagent needle scheduling device controls the reagent needle to suck the sample at the sampling site and add the sample to the reaction cup in the reaction chamber.
7. The medical instrument of claim 5, wherein the medical instrument is a chemiluminescent immunoassay analyzer.
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| CN111929450B (en) * | 2019-05-13 | 2023-04-07 | 深圳市帝迈生物技术有限公司 | Scheduling method for sample detection, sample detection device and storage medium |
| CN110456089B (en) * | 2019-08-28 | 2023-04-25 | 迈克医疗电子有限公司 | Full-automatic sample analyzer, reagent adding method and calculating device thereof |
| CN113049842B (en) * | 2019-12-27 | 2024-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis device, sample test pre-arrangement method, and storage medium |
| CN113125777A (en) * | 2019-12-31 | 2021-07-16 | 科美诊断技术股份有限公司 | Sample test item arrangement method and device |
| CN111735973B (en) * | 2020-06-30 | 2022-05-27 | 深圳市科曼医疗设备有限公司 | Sample analysis device and control method thereof |
| CN112014582B (en) * | 2020-08-31 | 2024-05-03 | 成都艾科斯伦医疗科技有限公司 | A fully automatic coagulation analyzer scheduling method |
| CN113125785B (en) * | 2021-03-29 | 2024-02-27 | 深圳市科曼医疗设备有限公司 | Method for detecting high-concentration sample and invoking time sequence |
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| CN102221626B (en) * | 2010-04-14 | 2015-04-22 | 深圳迈瑞生物医疗电子股份有限公司 | Automatic biochemistry analyzer and working method thereof |
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| US3193358A (en) * | 1962-07-02 | 1965-07-06 | Warner Lambert Pharmacentical | Automated analytical apparatus |
| CN1624484A (en) * | 2003-12-05 | 2005-06-08 | 株式会社日立高新技术 | Automatic analysis device and analysis method of automatic analysis device |
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