CN108125803A - A kind of whitening spot-eliminating composition - Google Patents

Abstract

The invention discloses a whitening and freckle-removing composition, which is made of the following raw materials in percentage by weight: 0.1-1.2% of fullerene, 1-5% of emulsifier, 3-9% of skin conditioning agent, and 1-20% of moisturizing agent , the balance of water, the composition can completely solve the problem of spots, repair the anti-damage ability of cells, fundamentally solve the problem of long spots, and cure without recurrence, especially the pigmentation caused by inflammation.

Description

Composition for whitening and removing freckles

technical field

The invention relates to the field of whitening and freckle removal, in particular to a product formula of a whitening and freckle removing composition containing fullerene.

Background technique

For a long time, whitening and freckle removal has been a hot topic of concern. Orientals hope to obtain fair and smooth skin through the use of whitening care products, while European and American consumers mainly use functional whitening cosmetics to reduce pigmentation such as age spots and chloasma. With the development of biochemical technology, people's understanding of the biological mechanism of melanin synthesis is deepening, and more and more researchers tend to look for safe and efficient whitening and anti-freckle active substances from natural plants.

The color of human skin mainly depends on the content and distribution of melanin, and the structure, function and quantity of melanocytes directly affect the content of melanin in the skin, and are the decisive factors for the production of melanin. Melanocytes are glandular cells, which contain melanin-forming organelles called melanosomes. Melanocytes have dendritic processes through which they form an epidermal melanin unit with keratinocytes. In the epidermal melanin unit, melanocytes and keratinocytes interact with each other, especially keratinocytes can contact and secrete basic fibroblast growth factor (hFGF), endothelin (ET-1), nerve cell growth factor (NGF), interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor (TNF), etc. have obvious effects on the morphology, structure and function of melanocytes. The dendrites of melanocytes are actually a pipe, through which the melanin produced in melanocytes is transported to keratinocytes, part of which is degraded by lysosomes in keratinocytes, and part of which is carried along with the metabolism of the cells. into the stratum corneum, and finally shed with the keratinocytes. But when melanin grows too fast and distributes unevenly, it will cause local skin to be too dark and pigmentation. There must be three substances involved in the synthesis of melanin: ① tyrosine is the main raw material for producing melanin; ② tyrosinase is the main rate-limiting enzyme for the conversion of tyrosine into melanin; ③ tyrosine is activated by tyrosinase Melanin is produced, and this action is an oxidation process, which must be combined with oxygen to be converted into melanin. The synthesis of melanin in melanocytes is a set of quite complicated processes. The currently recognized melanin synthesis pathway is: tyrosine-dopa-dopaquinone-dopachrome-5,6-dihydroxyindole-5 , 6-indole quinone - melanin, the synthetic melanin is called eumelanin, and the pigment of the skin is mainly composed of it.

Pigmentation is a representative of melanin that is easy to see on the face, including freckles, age spots, post-inflammatory hyperpigmentation, etc. Melanin is not necessarily all black, depending on the degree of melaninization, its color can be yellow, red, brown, black and other colors. The color of human skin and hair depends not on the number of melanocytes, but on the number, size, distribution and degree of melaninization of melanosomes. The number of melanocytes in the skin of people of different races is basically the same, but the number of melanocytes in the keratinocytes of black people is large, the shape is large, the degree of melanization is deep, the distribution is single, and the degradation is slow, while the keratinocytes of white people The number of melanosomes is small, the shape is small, the degree of melanization is light, and they are more aggregated and distributed in phagolysosomes, which are easy to degrade.

In recent years, new topical whitening agents have been developed rapidly, and the main mechanism of action is to achieve whitening effect by inhibiting tyrosinase. The mechanism of action against tyrosinase can be divided into inhibiting the activity of tyrosinase, reducing the production and synthesis of tyrosinase, inhibiting the glycation of tyrosinase, and accelerating the decomposition of tyrosinase. In addition, some whitening agents can act on other links of melanin formation and the transport and metabolism of melanin. According to different mechanisms of action, the currently developed whitening active ingredients mainly include: ingredients that inhibit tyrosinase activity, such as kojic acid and its derivatives, licorice flavonoids, mulberry extract, etc.; ingredients that reduce the production or synthesis of tyrosinase Ingredients, such as azelaic acid, placenta, lempuyang (Zinginer aromaticum), etc.; inhibit the glycosylation of tyrosinase, so that tyrosinase cannot be transported from the endoplasmic reticulum to the melanin body, and has the activity of this effect Components such as glucosamine, cartilage glycosaminoglycans, elastin, etc.; components that accelerate the decomposition of tyrosinase, such as linoleic acid and sublinolenic acid, etc.; components that reduce melanin and inhibit melanin synthesis, such as vitamin C and its derivatives substances, arbutin, etc.; components that inhibit the transfer of melanin granules to keratinocytes, such as nicotinamide, green tea extract, soybean extract, RWJ-50353, glycostatin, etc.; components that inhibit the combination of endothelin and melanocyte receptors , such as Western chamomile Matricacia, German chamomile, etc.; ingredients that soften the cuticle and accelerate the exfoliation of the cuticle (accelerate the excretion of melanin), such as if acid. In addition, some anti-ultraviolet ingredients will be added to whitening cosmetics to reduce the negative effects of ultraviolet rays and oxygen free radicals on the physiological process of melanin formation. However, in the existing freckle-removing products, the freckle-removing effect is not obvious, or new spots are produced after freckle-removing in a short period of time.

The large π-bonded conjugated system composed of multiple P orbitals of fullerene makes it have a strong ability to accept electrons. Because of its unique structure and physical and chemical properties, it has excellent free radical scavenging performance, known as The "free radical sponge" also exhibits excellent antioxidant properties. It has been widely concerned in cosmetic materials, biomedicine and other aspects.

By embedding C60 into surfactants, C60 can still eliminate reactive oxygen species in cells, inhibit mitochondrial depolarization, activation of cysteine proteases, exposure of phosphatidylserine on cell membranes, and DNA cleavage, and C60 exhibits Protect cells from oxidative apoptosis. C60 liposome complex plays an anti-oxidant role by defending against UVA damage to skin structure, cell nucleus and collagen fibers, and penetrating into human skin tissue. It is 172 times that of vitamin C and can affinity free radicals.

Professor Fathi Moussa has been engaged in the research on the properties of C60 for a long time. As the first person to study dissolving fullerene in olive oil, they fed mice 10-17 months every two weeks (feeding 4 mg richerene per kg body weight) Fullerene), the mice in the control group died within 17-38 months, while the life span of the experimental group was extended to 59-66 months. It was found that fullerene has a longevity health care function. During the period, regardless of body weight, there was no abnormality in physiological performance, and no toxicity or biological heredity of C60 was found. On the contrary, a certain amount of C60 has the ability to scavenge free radicals, thereby protecting animals from the harm of excessive free radicals. Patent 2004800222529 discloses a cosmetic composition containing fullerene clusters. The composition contains fullerene clusters and carriers to prevent or delay the oxidation process of free radicals in the skin. The technical content in this patent does not form protection on the skin surface layer, just to properly repair the skin. CN201510074653.9 discloses a cosmetic containing fullerene derivatives, which includes fullerene, vitamins, polypeptides, sodium hyaluronate, collagen, oat polysaccharide, hyaluronic acid, niacinamide, glycerin, 1,3 - Propylene Glycol, Phenylethyl Resorcinol, Astaxanthin etc. It has anti-aging, restores skin vitality, can effectively reduce melanin production, promote collagen synthesis, and also has anti-inflammatory and anti-acne effects. But this patent freckle effect is relatively poor, especially the pigmentation caused by inflammation.

Contents of the invention

In order to solve the above technical problems, the present invention provides a composition that can completely solve the problem of spots, repair the anti-injury ability of cells, cure without recurrence, and fundamentally solve the problem of spots, especially the pigmentation caused by inflammation.

The present invention realizes through following technical scheme:

A whitening and spot-removing composition, characterized in that it is made of the following raw materials in weight percentage: 0.1-1.2% of fullerene, 1-5% of emulsifier, 3-9% of skin conditioning agent, and 1-20% of moisturizing agent , the balance of water.

More preferably, a whitening and freckle-removing composition is characterized in that it is made of the following raw materials in percentage by weight: 0.4-1% of fullerene, 2-4% of emulsifier, 5-8% of skin conditioning agent, and 8% of moisturizing agent -15%, balance water.

More preferably, a whitening and freckle-removing composition is characterized in that it comprises the following raw materials in weight percentage: preferably 0.6% of fullerene, 3.25% of emulsifier, 6.4% of skin conditioner, 12% of moisturizing agent, and the balance water.

The active ingredient in the freckle-removing and whitening composition of the present invention is fullerene, which has a freckle-removing and whitening effect, especially for post-inflammatory pigmentation. After the oxidative stress received by the human skin, some inflammatory factors will be produced, and the inflammatory factors will activate some receptors, and the receptors activate melanocytes to produce excess melanin. The fullerene in the composition of the present invention has the function of anti-oxidation and inhibition of inflammatory factors, inhibits the activity of oxygen free radicals, controls the oxidation of tyrosinase, and can inhibit the production of tyrosinase by melanocytes to form more melanin.

In the above freckle removing composition, the fullerene is one or more of hollow fullerenes, metal fullerenes, heterocyclic fullerenes and embedded fullerenes. Including but not limited to fullerenes C _2n , M@C _2n , M ₂ @C _2n , MA@C _2n , M ₃ N@C _2n , M ₂ C ₂ @C _2n , M ₂ S@C _2n , M ₂ Any of O@C _2n and M _x A _3-x N@C _2n , wherein M and A are metal elements, and the M and A are all selected from any of Sc, Y and lanthanide metal elements a; 30≤n≤60; 0≤x≤3.

It is further preferred that the fullerene is selected from C ₆₀ , C ₇₀ , C ₇₆ , C ₈₄ , Gd@C82 and a mixture of one or more derivatives thereof.

The skin conditioner of the present invention is composed of the active ingredient fullerene complex, water-soluble oily ester, synthetic oily ester, polymer according to weight ratio (0.05-0.5):(1-5):(1 -5): (0.1-0.5) composition.

Further preferably, the skin conditioning agent is composed of active fullerene complex components, water-soluble oily esters, synthetic oily esters, and polymers in a weight ratio of 0.1:3:3:0.3.

The complex ingredients of the active substances in the above skin conditioners include but are not limited to dipotassium glycyrrhizinate, arbutin, niacinamide, ascorbyl tetraisopalmitate, tranexamic acid, linoleic acid, VC, kojic acid, white Rucinol, ellagic acid, coumaric acid, etc., preferably dipotassium glycyrrhizinate, nicotinamide, coumaric acid, more preferably dipotassium glycyrrhizinate. The dipotassium glycyrrhizinate prevents the release of histamine in the composition of the present invention, can accelerate melanin metabolism, and can inhibit the migration rate of melanin from the mechanism layer to the epidermis. Fullerene can inhibit the inflammatory factors that induce melanin production, and the combination of the two synergistically produces the effect of whitening and freckle removal without recurrence for a long time. The nicotinamide can accelerate melanin metabolism, can inhibit the migration rate of melanin from the mechanism layer to the epidermis layer, has the same effect as dipotassium glycyrrhizinate, and has a good compounding effect with fullerene.

The synthetic oil esters mentioned in the above skin conditioners include but are not limited to liquid paraffin, liquid petrolatum, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, unsaturated fatty acids such as palmitate oleate One or more of stearic acid, behenic acid, linoleic acid, and 16/18 alcohol. More preferably, the synthetic fat is 16/18 alcohol. The 16/18 alcohol described in the present invention acts as an emollient, has good touch substances, and makes the skin appear smooth, soft and lubricated after being applied.

Water-soluble oil esters mentioned in the above skin conditioners such as water-soluble olive oil ester, rice bran oil ester, water-soluble sunflower seed oil, water-soluble palm oil ester, water-soluble soybean oil, water-soluble sesame oil, water-soluble peach kernel oil, water-soluble corn oil Oily esters, water-soluble jojoba oil esters, water-soluble hemp seed oil esters, water-soluble cottonseed oil esters, water-soluble coconut oil, water-soluble babassu oil esters, water-soluble almond oil or a mixture of several. More preferably, water-soluble olive oil esters, water-soluble jojoba oil esters, water-soluble sunflower oil esters, water-soluble avocado oil esters, and water-soluble wheat germ oil esters. The water-soluble oil selected in the present invention has a good touch substance, which makes the skin feel smooth, soft and lubricated after being applied.

The high molecular polymer described in the above skin conditioner is polyquaternium, most preferably polyquaternium-10. Polyquaternium-10 (PQ400), Chinese alias: chloride-2-hydroxy-3-(trimethylamino)propyl polyethylene oxide cellulose ether, CAS number: 68610-92-4. The polyquaternium-10 solution volatilizes with the water, and the polyquaternium-10 forms a network structure due to intermolecular interactions, forming a film that can retain a certain amount of water, and at the same time absorbs quickly due to the film-forming property. Polyquaternium-10 is used for skin with excellent after-use feeling, improves skin's anti-ultraviolet ability, excellent moisturizing performance, and has anti-washing ability.

Further preferred skin conditioners include dipotassium glycyrrhizinate or niacinamide, 16/18 alcohol, water soluble olive oil ester, polyquaternium-10 in weight ratio (0.05-0.5):(1-5):(1-5 ): (0.1-0.5) composition. More preferably, the skin conditioner is composed of dipotassium glycyrrhizinate, 16/18 alcohol, water-soluble olive oil ester, and polyquaternium-10 in a weight ratio of 0.1:3:3:0.3. The selection and proportioning of the skin conditioning agent of the present invention can well cooperate with the whitening and freckle-removing effect of the fullerene active ingredient, especially the elimination and improvement of freckles caused by inflammation, the freckles are quickly removed without rebound, and the skin is lubricated and delicate. It has excellent spreadability, lubricity, moisturization, moisture retention and air permeability.

Moisturizing agent of the present invention is glycerin, butylene glycol, polyethylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol, isopropyl palmitate, vaseline, polydimethyloxysilane 1 or more of sodium hyaluronate.

Further preferably, the moisturizing agent is glycerin, vaseline, isopropyl palmitate, and polydimethylsiloxane according to the weight ratio (2-10):(2-5):(1-5):(1-5) compound.

Further preferably, the moisturizing agent is glycerin, vaseline, isopropyl palmitate, and polydimethylsiloxane according to the weight ratio (4-6):(2-4):(1-3):(1-3) compound.

More preferably, the moisturizing agent is compounded with glycerin, vaseline, isopropyl palmitate, and polydimethylsiloxane in a weight ratio of 5:3:2:2.

For the moisturizer of the present invention, the inventors found that small molecule moisturizers such as glycerin, propylene glycol, butanediol, etc. are commonly used in large quantities. They have hydroxyl groups in their molecules. After being used on the skin, they rely on hydrogen bonds to capture the moisture in skin care products. Lives and stays on skin. This kind of small molecule moisturizer has small molecular weight, strong permeability, and is easy to enter the gap of keratinocytes. However, when the amount of this kind of small molecule moisturizer exceeds 8%, it will cause irritation, especially when cosmetics contain oils, emulsifiers, etc. In order to enhance the moisturizing properties of the ingredients, a large amount of small molecular components such as glycerin need to be added, but the irritation increases accordingly. In order to avoid strong irritation, isopropyl palmitate is added in the moisturizer combination of the present invention, which plays the role of moisturizing and moisturizing the skin. The skin has better absorption of this product and can effectively interact with hair follicles in the cortex. Contact, penetrate deep into the skin layer, and bring in the active ingredients in the cosmetics to give full play to the effect of the active ingredients. Vaseline and Dimethicone both smooth the skin. The selection of the moisturizing agent of the present invention and the film-forming property of the polyquaternium salt in the skin conditioning agent can better coordinate the moisturizing effect.

The emulsifier of the present invention is preferably cetyltrimethylammonium chloride (1631), behenyl alcohol and arachidyl glucoside (CS200), polyethylene glycol (100) stearate and glyceryl stearate (E165), stearic acid, sorbitan sesquioleate, macrogol-30, cetyltrimethylammonium chloride, dipolyhydroxystearate, lecithin, stearic acid One or more of magnesium. Further preferred cetyl trimethyl ammonium chloride, behenyl alcohol and arachidyl glucoside, polyethylene glycol (100) stearate and glyceryl stearate according to weight ratio (0.1-1): (1- 5): (0.5-2) Compounding. It is further preferred to compound cetyltrimethylammonium chloride, behenyl alcohol and arachidyl glucoside, polyethylene glycol (100) stearate and glyceryl stearate in a weight ratio of 0.25:2:1. The compounding of the emulsifier can make the paste delicate and beautiful, and the use effect is the best. Among them, cetyltrimethylammonium chloride has good stability and is a deflocculant.

As components that can be blended, preservatives, fragrances, and the like can also be added to the composition of the present invention.

The preservative is preferably added to the composition in an amount of 0.2-1%, preferably 0.5-0.8%. The preservatives include water-soluble preservatives and oily preservatives. Preferably, one or more of methylparaben, propylparaben, phenoxyethanol, ethylhexylglycerin, and tert-butylhydroquinone are selected. In order to achieve a better antiseptic and bactericidal effect, the use of a preservative often seriously exceeds the safe dosage, which brings potential safety hazards. Further preferred preservatives select methylparaben: propylparaben: phenoxyethanol/methylisothiazolinone is (0.5-2): (0.5-2): (2-5) according to the weight ratio compound. Further preferably, the preservative is selected from methylparaben: propylparaben: phenoxyethanol/methylisothiazolinone compounded according to the weight ratio of 1.2:1:4. The compounded preservative system of the present invention has a synergistic antibacterial effect, and under the premise of reducing the safe and effective usage amount of each, it can still maintain sufficient bactericidal ability when used in combination, and is safe and has no side effects. It can also avoid secondary pollution, especially the bactericidal effect on mold, prolong the shelf life of products and ensure product quality.

The dosage of the aromatic agent is 0.01-0.05%.

All moisturizers, skin conditioners, emulsifiers, preservatives, fragrances, actives of the present invention are commercially available.

Beneficial effect

1. The active ingredient in the freckle-removing and whitening composition of the present invention is fullerene, which has a freckle-removing and whitening effect, especially for post-inflammatory pigmentation. After the oxidative stress received by the human skin, some inflammatory factors will be produced, and the inflammatory factors will activate some receptors, and the receptors activate melanocytes to produce excess melanin. The fullerene in the composition of the present invention has the function of anti-oxidation and inhibition of inflammatory factors, inhibits the activity of oxygen free radicals, controls the oxidation of tyrosinase, and can inhibit the production of tyrosinase by melanocytes to form more melanin. The dipotassium glycyrrhizinate prevents the release of histamine in the composition of the present invention, can accelerate melanin metabolism, and can inhibit the migration rate of melanin from the mechanism layer to the epidermis. Fullerene can inhibit the inflammatory factors that induce melanin production, and the combination of the two synergistically produces the effect of whitening and freckle removal without recurrence for a long time. The water-soluble oil selected in the present invention has a good touch substance, which makes the skin feel smooth, soft and lubricated after being applied. The selection and proportioning of the skin conditioning agent of the present invention can well cooperate with the whitening and freckle-removing effects of the fullerene active ingredient, especially for the elimination and improvement of freckles caused by inflammation, and the freckles are quickly removed without recurrence, and the skin is lubricated and delicate. It has excellent spreadability, lubricity, moisturization, moisture retention and air permeability. The film-forming properties of the moisturizing agent selected in the present invention and the polyquaternium salt in the skin conditioning agent can better coordinate the moisturizing effect. The components are compounded together to quickly lighten the spots, and to a certain extent, whiten and remove the spots, without recurring after the spots are removed. The spots described in the present invention are melanosis, including but not limited to freckles, age spots, chloasma, pregnancy spots, acne, post-inflammatory pigmentation and the like. The composition is very easy to penetrate the stratum corneum of the skin, is easier to absorb and utilize, and is easier to exert its efficacy, and the skin is lubricated and delicate.

2. The composition of the present invention has curative effect on various spots caused by melanosis, high cure rate, and no recurrence. The composition of the invention has little irritation, no side effect and can be used for a long time.

3. The composition of the present invention is stable, easy to store, and does not delaminate or flocculate under high and low temperature environments.

4. The composition of the present invention is delicate, mild, strong skin-adhesive, easy to apply and absorb.

5. The antiseptic system compounded by the formula of the present invention has broad-spectrum antibacterial properties, less dosage after compounding and improved safety.

Description of drawings

Accompanying drawing 1 is the process flow chart of composition of the present invention.

Detailed ways

Specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

Table 1 Example 1-5

Preparation process: Put the weighed A phase raw materials into the water phase pot, stir and heat to 85°C, add the C phase raw materials after stirring evenly, put the weighed B phase raw materials into the oil phase pot and dissolve completely at 85°C. Preheat the emulsification pot to 60-70°C, vacuum the water phase and oil phase, stir homogeneously (4000r/min), cool to 45°C, add D and E, stir until uniform, and discharge. Semi-finished products are filled after passing the inspection, and finished products are put into storage after passing the inspection. The process flow is shown in Figure 1.

Table 2 Examples 6-10

Preparation process: Put the weighed A phase raw materials into the water phase pot, stir and heat to 85°C, add the C phase raw materials after stirring evenly, put the weighed B phase raw materials into the oil phase pot and dissolve completely at 85°C. Preheat the emulsification pot to 60-70°C, vacuum the water phase and oil phase, stir homogeneously (4000r/min), cool to 45°C, add D and E, stir until uniform, and discharge. Semi-finished products are filled after passing the inspection, and finished products are put into storage after passing the inspection.

Test example 1: Freckle removal effect test

Medicine: get the freckle-removing composition of embodiment 1,

Select 50 middle-aged women aged 40-50 to conduct effect test. Divide into five groups of 10 people each. Group A-E. Group A: chloasma, group B freckles, group C age spots, group D pregnancy spots, group E pigmentation after acne inflammation. The average level of feedback from each group of people participating in the test was taken. Those who participated in the test used it twice a day, once in the morning and once in the evening, and took an appropriate amount and applied it to the face. They could use some more products on the plaques and massage them moderately. The test time is 30 days, and the follow-up subjects no longer use professional blemish-reducing products, only carry out routine skin care, and continue to observe for 3 months.

Table 3 Freckle removal effect

It can be seen from the freckle removal effect in Table 3 that the composition of the present invention has obvious lightening and whitening effects, especially the freckles caused by inflammation. It can quickly remove freckles, and it will be effective in 7 days, and the freckles can be completely removed in one month, and the skin is fair and clear. After 30 days of use, stop using the spots will not reappear to achieve the effect of long-term no spots, this product has no dependence.

All the compositions within the scope of the embodiments and claims of the present invention have the same rapid freckle-removing and whitening effects as the embodiments, and the effect is not repeated after stopping use.

Test example two, the synergistic effect of the whitening and spot-removing composition of the present invention

Compositions of the invention: Example 1

Contrast group 1: embodiment 1 does not contain the formula of dipotassium glycyrrhizinate

Contrast group 2: embodiment 1 does not contain the formula of fullerene

The composition of the present invention does not recur freckles after freckle removal, and the skin color becomes brighter and brighter day by day. Using the subjects in the comparison group 1, the freckle removal effect can be achieved, but the time is slightly longer. The subjects who used the comparison group 2 had no obvious freckle removal effect, and after stopping the use, the skin gloss would be repeated.

Test example 3. Selection test of anti-corrosion system

According to the Cosmetic, Toiletry and Fragrance Federation (CTFA Act). Weigh 100g of products with different antiseptic systems, add them into sterilized containers, add 1ml each of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger, and shake well. Samples were taken and analyzed on days 0, 7, 14, 21, and 28 of inoculation. If the amount of surviving bacteria is less than 100CFU/g 7 days after the addition of bacteria, and all drop to 0 within 28 days, it is considered excellent and passed the challenge. If the number of surviving bacteria is less than 1000 at 7 days, it is regarded as barely passing, and if the number of surviving bacteria is more than 1000 at 7 days, it is regarded as failing the antiseptic challenge. The results are shown in Table 4

Table 4 Preservative selection test

The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. These descriptions are not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application, thereby enabling others skilled in the art to make and use various exemplary embodiments of the invention, as well as various Choose and change. It is intended that the scope of the invention be defined by the claims and their equivalents.

Claims (10)

1. a whitening and spot-removing composition, is characterized in that, comprises the raw material of following percentage by weight to make: fullerene 0.1-1.2%, emulsifier 1-5%, skin conditioning agent 3-9%, humectant 1- 20%, balance water. 2. The whitening and freckle-removing composition according to claim 1, characterized in that, it comprises the following raw materials in percentage by weight: fullerene 0.4-1%, emulsifier 2-4%, skin conditioning agent 5-8% , Humectant 8-15%, the balance water. 3. The whitening and freckle-removing composition according to claim 2, characterized in that, it comprises the following raw materials in weight percentage: 0.6% of fullerene, 3.25% of emulsifier, 6.4% of skin conditioning agent, 12% of moisturizing agent, Balance water. 4. The whitening and freckle-removing composition according to any one of claims 1 and 3, wherein the moisturizing agent is glycerin, petrolatum, isopropyl palmitate, and polydimethylsiloxane according to the weight ratio (2-10):(2-5):(1-5):(1-5) Compounding. 5. The whitening and freckle-removing composition according to any one of claims 1 and 3, wherein the emulsifier is cetyltrimethylammonium chloride, behenyl alcohol and arachidyl glucoside, polyethylene glycol Alcohol 100 stearate and glyceryl stearate are compounded according to the weight ratio (0.1-1):(1-5):(0.5-2). 6. The whitening and freckle-removing composition according to any one of claims 1 and 3, characterized in that: the skin conditioner is composed of a compound component of fullerene, water-soluble oily ester, synthetic oily ester, polymer polymer The composition is according to the weight ratio (0.05-0.5):(1-5):(1-5):(0.1-0.5). 7. The whitening and freckle-removing composition according to claim 6, characterized in that: the fullerene compound ingredients include dipotassium glycyrrhizinate, arbutin, nicotinamide, ascorbyl tetraisopalmitate, tranexamic acid, Linoleic acid, VC, kojic acid, resveratrol Rucinol, ellagic acid, coumaric acid; the synthetic oil esters include liquid paraffin, liquid petrolatum, isopropyl myristate, isopropyl palmitate, palmitic acid 2-Ethylhexyl ester, unsaturated fatty acid, one or more of oleic palmitic acid, stearic acid, behenic acid, linoleic acid, and 16/18 alcohol; the water-soluble oily ester includes water-soluble olive oil Esters, Rice Bran Oil Esters, Water Soluble Sunflower Seed Oil, Water Soluble Palm Oil Esters, Water Soybean Oil, Water Soluble Sesame Oil, Water Soluble Peach Kernel Oil, Water Soluble Corn Oil Esters, Water Soluble Jojoba Oil Esters, Water Soluble Hemp Seed Oil ester, water-soluble cottonseed oil ester, water-soluble coconut oil, water-soluble babassu oil ester, water-soluble almond oil or a mixture of several kinds; the high molecular polymer is polyquaternium. 8. whitening and speckle-removing composition as claimed in claim 7, is characterized in that: described skin conditioner comprises dipotassium glycyrrhizinate, 16/18 alcohol, water-soluble olive oil ester, polyquaternium-10 according to weight ratio ( 0.05-0.5):(1-5):(1-5):(0.1-0.5) Compounding. 9. whitening and speckle-removing composition as claimed in claim 8, is characterized in that, skin conditioner comprises dipotassium glycyrrhizinate, 16/18 alcohol, water-soluble olive oil ester, polyquaternium-10 according to weight ratio 0.1:3 :3:0.3 Compounding. 10. The whitening and freckle-removing composition according to any one of claims 1 and 3, characterized in that: it also includes a preservative dosage of 0.2-1%, and the preservative is methylparaben: propylparaben : Phenoxyethanol/methylisothiazolinone is (1-2):(0.5-2):(2-5) compounded by weight.