CN108042658A - A kind of valerian seedling medicine sleep essential oil composition and its preparation method and application - Google Patents
A kind of valerian seedling medicine sleep essential oil composition and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of valerian seedling medicine sleep essential oil compositions and its preparation method and application, belong to essential oil technical field.The essential oils are prepared including following raw material by weight percentage：Oleic acid/linoleic acid/leukotrienes polyglycereol esters 60~85%, valerian essential oil 2~20%, Blumea balsamifera essential oil 2~15%, Fructus Perillae quintessence oil 1~5%, sandalwood essential oil 1~4%, thousand layers of chrysanthemum essential oil 1~10%, Lavender 1~8%.Prepared elite is glossy without greasy, can treat the poor sleep caused by the mild or moderate, sleep is shallow, sleep less, dreaminess, difficulty falling asleep, easily wake up and minor depressive in terms of disease；Valerian seedling medicine of the present invention sleep essential oil application method is：Preceding 30 points of kinds are slept, this product is taken to embrocate temple or the related acupuncture point of sleep, daily 1~2 time.This product stability is good, and the absorptivity of skin is high, sleep improvement is acted on apparent.
Description
Technical field
The invention belongs to essential oil technical fields, and in particular to a kind of valerian seedling medicine sleep essential oil composition and preparation method thereof
And application.
Background technology
The effect of plant doctor's essential oil is well known, nothing more than releive and inspire enthusiasm it is this be relatively inclined to it is psychological
Effect, but not only in this effect of essential oil.Different types of essential oil also has a variety of effects, for some diseases,
There is the function of releiving and mitigate symptom.Essential oil is all helpful to many diseases, and the treatment with composite medicine can allow disease extensive
It is multiple faster.And the effect of using in daily life, purification air, disinfection, sterilization can be played, while one can be prevented
A little communicable diseases.Essential oil is for endocrine, metabolism, urinary system, venereal disease, immune system, gynecological disease, muscle, bone
Bone disease, skin disease, the symptom of body and disease, nervous system and mental illness, eye, nose, oral cavity, odontopathy, are exhaled at ear
The disease in terms of disease, blood circulation system, the disease in terms of digestive system in terms of desorption system have the effect of all well and good.Essential oil
Because itself natural characteristic and molecule are small, easily into human body reach certain effects the advantages of, be widely applied.
With the increasing of life stress, the sleep quality of people cannot be guaranteed, and evening summer mosquito bites in addition,
Even more people is allowed to lie awake all night, the state of mind is bad within second day, seriously affects normal work and study.
The patent of invention " one that State Intellectual Property Office disclosed Publication No. CN103120756A on May 29th, 2013
Kind improve the compound essential oil of sleep of pregnant woman ", disclosure of the invention compound essential oil raw material by weight point：Aloe essential oil 15~
30 parts, 10~15 parts of jasmine essential oil, 10~15 parts of orchid essential oil, 10~15 parts of tangerine oil, containing 10~15 parts of essential oil of tobaccos；
Its raw material is put into stirring container, room temperature stirring at low speed makes each raw material fully be mixed evenly, encapsulation,.It is a kind of whole day
So, securely and reliably, the compound essential oil harmless to pregnant woman.Jasmine essential oil in the invention accounts for significant proportion, and relevant information is shown：
Refined jasmine oil, which removes to have, pacifies nerve, is consoled mood, can enhance self-confidence.Antidepression sets the mind at rest, increases confidence,
Also there is the stronger ability of promoting the sexual maturity.If amount is few, calm nerves are not achieved, improve sleeper effect, dosage can then cause greatly
It sleeps bad, therefore jasmine essential oil is not suitable for improving in the compound essential oil slept.
Patent of invention " the tool that State Intellectual Property Office disclosed Publication No. CN102755271A on October 31st, 2012
Have compound essential oil for decompression function of releiving and preparation method thereof ", the disclosure of the invention is a kind of to be had the function of to releive the compound of decompression
Essential oil and preparation method thereof, it is characterised in that：Compound essential oil component by weight calculates, and has 0.10~1 part of valerian oil, smokes clothing
900~100 parts of careless 0.3~1.5 part of oil, 0.1~0.5 part of pelargonium oil, 0~1.5 part of natural deodorant tune and camellia oil compositions.From
In formula as can be seen that wherein for the component for pressure of releiving：Valerian oil, lavender oil and pelargonium oil content are seldom, with people
Conventional amount used, effect be not apparent.
The content of the invention
The shortcomings that in order to overcome the prior art and deficiency, primary and foremost purpose of the invention are to provide a kind of valerian seedling medicine sleep
Essential oil.The ductility of the essential oils is good, safe and non-stimulating, easily absorbs, can effectively facilitate sleep, stress of releiving, Quan Fang
Position makes one to cool it, and can improve sleeping problems to greatest extent.
Another object of the present invention is to provide the preparation method of above-mentioned sleep essential oil.
It is still another object of the present invention to provide the applications of above-mentioned sleep essential oil.
The purpose of the present invention is achieved through the following technical solutions：
A kind of valerian seedling medicine sleep essential oil, is prepared including following raw material by weight percentage：
In the medicine sleep essential oil, oleic acid/linoleic acid/leukotrienes polyglycereol esters, valerian essential oil, Blumea balsamifera essential oil, purple
The sum of Soviet Union's essential oil, sandalwood essential oil, thousand layers of chrysanthemum essential oil and Lavender each component weight percent are 100%.
Preferably, the raw material that the valerian seedling medicine sleep essential oil includes following weight percentage is prepared：
In inventive formulation, oleic acid/linoleic acid/leukotrienes polyglycereol esters are as plant skin sense conditioner, institute in structure
The Long carbon chain contained makes it have preferable moisturizing characteristic and very slim and graceful smooth skin sense, contained special macromolecule
Plant molecular can absorb moisture of 200 times more than skin itself, effectively facilitate skin absorption, and the quick of derived essential oil is helped to ooze
Thoroughly, so as to improve sleep quality.
1st, valerian essential oil, which has, releives, puts down and comfort nervous nerve, releases the effect of smooth muscle spasm, makes height due to anxiety emerging
The nervous system put forth energy faster into relaxation state, to have the function that calm, hypnosis, increases peripheral blood mononuclear cells and abdominal cavity
The expression quantity of interleukin in macrophage promotes the secretion of 5~hydroxytryptamine, inhibits the liveness of cerebral neuron, it is latent to shorten sleep
Fu Qi.
2nd, Blumea balsamifera essential oil：Appropriate Blumea balsamifera essential oil, which has, releives, is calm and skin and bronchia mucosal is promoted to inhale essential oil
The effect of receipts.
3rd, thousand layers of chrysanthemum essential oil：There is calm, tranquilizing the mind, analgesia and cardiac stimulant.
4th, indian sandalwood essential oil：With anti-inflammation and sterilization, muscular tone of releiving, prevent varication, promotion Lymphatic Circulation.It is right
Neurological disorders, depressed and anxiety good action.
5th, Fructus Perillae quintessence oil：The traditional Chinese medical science thinks there is antibechic, antipyretic, calm, improvement sleep.
6th, Lavender：It is capable of the respiratory center of strong stimulation people, so as to promote human body inspiration oxygen, excludes two
Carbonoxide promotes blood circulation；It can relaxation alimentary canal spasm, prevention nauseous dizzy, mitigation anxiety and nervous migraine etc..
A kind of valerian seedling medicine sleep essential oil, comprises the following steps：
(1) prefabricated foundation oil
Under conditions of stirring, oleic acid/linoleic acid/leukotrienes polyglycereol esters are added in into reactor, it is warming up to 55~
It 60 DEG C, is stirred, is cooled to 40~45 DEG C, stirs evenly, obtain prefabricated foundation oil；
(2) essential oil is prepared
Under stirrings, valerian essential oil, Blumea balsamifera essential oil, Fructus Perillae quintessence oil are sequentially added into reactor and is stirred evenly,
Sandalwood essential oil, thousand layers of chrysanthemum essential oil, Lavender are added in, continue to stir, is uniformly mixed, obtains essential oil；
(3) under conditions of stirring, essential oil prepared by step (2) is added in into step (1) prefabricated foundation oil, mixing is equal
Even, filtering obtains valerian seedling medicine sleep essential oil.
180~the 250r/min of rotating speed stirred described in step (1)；The time being stirred is 3~10min；Stirring is equal
The even time is 8~15min.
150~the 250r/min of rotating speed stirred described in step (2)；The time stirred evenly is 3~5min, described
Continue the time of stirring as 1~3min, the time of mixing is 1~3min；The temperature of the stirring and mixing is room temperature.
250~300r/min of rotating speed of stirring in step (3)；The time of mixing is 8~15min, and the temperature of mixing is room
Temperature.
The valerian seedling medicine sleep essential oil is preparing treatment because of spirit and the mild or moderate of operating pressure or system of leading of being overexcited
Application in terms of difficulty falling asleep, bad, not depth of sleeping of sleeping and minor depressive.
Valerian seedling medicine sleep essential oil application method is：Preceding 30 points of kinds are slept, this product is taken to embrocate temple or sleep correlation
Acupuncture point, daily 1~2 time.
The present invention has the beneficial effect that：
(1) added using the effect of valerian is preferable calm, relieving mental strain and helping sleep, the interworking for being subject to the essential oils such as santal, thousand layers of chrysanthemum rises
To the significantly more effect for helping sleep
(2) blumea oil is added on the basis of above-mentioned formula, to promote the Transdermal absorption effect of external essence oil, makes to own
Effective component can be able to rapidly enter blood circulation rapidly by human skin and mucosal absorption, within a short period of time (0.5~
1h) play the role of significantly helping sleep.
(3) valerian seedling medicine sleep essential oil provided by the invention can be employed in cosmetics and healthcare field, in treatment because in
Sleep caused by slight is bad, depth and minor depressive aspect do not have preferable application for sleep.
Description of the drawings
Fig. 1 is schemed for patient using sensory evaluation after valerian seedling medicine sleep essential oil.
Specific embodiment
It is limited technical scheme is further, but is required with specific embodiment below in conjunction with the accompanying drawings
The scope of protection is not only limited to made description.
Embodiment one
A kind of valerian seedling medicine sleep essential oil, is prepared by the raw material of following weight percentage：
A kind of valerian seedling medicine sleep essential oil, comprises the following steps：
(1) prefabricated foundation oil
Under conditions of stirrings, oleic acid/linoleic acid/leukotrienes polyglycereol esters are added in into reactor, are warming up to 57 DEG C,
It is stirred, is cooled to 42 DEG C, stirs evenly, obtain prefabricated foundation oil；
(2) essential oil is prepared
Under stirring, valerian essential oil, acid Zao essential oils are sequentially added into reactor, is stirred evenly, add in santal essence
Oil continues to stir, and is uniformly mixed, obtains essential oil；
(3) under conditions of stirring, essential oil prepared by step (2) is added in into step (1) prefabricated foundation oil, mixing is equal
Even, filtering obtains valerian seedling medicine sleep essential oil.
The rotating speed 220r/min stirred described in step (1)；The time being stirred is 5min；The time stirred evenly is
11min。
The rotating speed 200r/min stirred described in step (2)；The time stirred evenly is 4min, described to continue to stir
Time for 2min, the time of mixing is 2min；The temperature of the stirring and mixing is room temperature.
The rotating speed 270r/min of stirring in step (3)；The time of mixing is 12min, and the temperature of mixing is room temperature.
Bad, sleep is deep and slight suppression preparing treatment caused by mild or moderate and sleep for valerian seedling medicine sleep essential oil
The application of strongly fragrant aspect.
Valerian seedling medicine sleep essential oil application method is：Preceding 30 points of kinds are slept, this product is taken to embrocate temple or sleep correlation
Acupuncture point, 2 times a day.
Embodiment two
A kind of valerian seedling medicine sleep essential oil, is prepared by following raw material by weight percentage：
A kind of valerian seedling medicine sleep essential oil, comprises the following steps：
(1) prefabricated foundation oil
Under conditions of stirrings, oleic acid/linoleic acid/leukotrienes polyglycereol esters are added in into reactor, are warming up to 60 DEG C,
It is stirred, is cooled to 45 DEG C, stirs evenly, obtain prefabricated foundation oil；
(2) essential oil is prepared
Under stirring, valerian essential oil, acid Zao essential oils are sequentially added into reactor, is stirred evenly, add in santal essence
Oil continues to stir, and is uniformly mixed, obtains essential oil；
(3) under conditions of stirring, essential oil prepared by step (2) is added in into step (1) prefabricated foundation oil, mixing is equal
Even, filtering obtains valerian seedling medicine sleep essential oil.
The rotating speed 250r/min stirred described in step (1)；The time being stirred is 10min；The time stirred evenly
For 15min.
The rotating speed 250r/min stirred described in step (2)；The time stirred evenly is 5min, described to continue to stir
Time for 3min, the time of mixing is 3min；The temperature of the stirring and mixing is room temperature.
The rotating speed 300r/min of stirring in step (3)；The time of mixing is 15min, and the temperature of mixing is room temperature.
Bad, sleep is deep and slight suppression preparing treatment caused by mild or moderate and sleep for valerian seedling medicine sleep essential oil
The application of strongly fragrant aspect.
Valerian seedling medicine sleep essential oil application method is：Preceding 30 points of kinds are slept, this product is taken to embrocate temple or sleep correlation
Acupuncture point, 2 times a day.
Embodiment three
A kind of valerian seedling medicine sleep essential oil, is prepared by following raw material by weight percentage：
A kind of valerian seedling medicine sleep essential oil, comprises the following steps：
(1) prefabricated foundation oil
Under conditions of stirrings, oleic acid/linoleic acid/leukotrienes polyglycereol esters are added in into reactor, are warming up to 55 DEG C,
It is stirred, is cooled to 40 DEG C, stirs evenly, obtain prefabricated foundation oil；
(2) essential oil is prepared
Under stirring, valerian essential oil, acid Zao essential oils are sequentially added into reactor, is stirred evenly, add in santal essence
Oil continues to stir, and is uniformly mixed, obtains essential oil；
(3) under conditions of stirring, essential oil prepared by step (2) is added in into step (1) prefabricated foundation oil, mixing is equal
Even, filtering obtains valerian seedling medicine sleep essential oil.
The rotating speed 180r/min stirred described in step (1)；The time being stirred is 3min；The time stirred evenly is
8min。
The rotating speed 150r/min stirred described in step (2)；The time stirred evenly is 3min, described to continue to stir
Time for 1min, the time of mixing is 1min；The temperature of the stirring and mixing is room temperature.
The rotating speed 250r/min of stirring in step (3)；The time of mixing is 8min, and the temperature of mixing is room temperature.
Bad, sleep is deep and slight suppression preparing treatment caused by mild or moderate and sleep for valerian seedling medicine sleep essential oil
The application of strongly fragrant aspect.
Valerian seedling medicine sleep essential oil application method is：Preceding 30 points of kinds are slept, this product is taken to embrocate temple or sleep correlation
Acupuncture point, one time a day.
Example IV (high dose group)
A kind of valerian seedling medicine sleep essential oil, is prepared by following raw material by weight percentage：
Preparation method is the same as embodiment 1.
Embodiment five (low dose group)
A kind of valerian seedling medicine sleep essential oil, is prepared by following raw material by weight percentage：
Preparation method is the same as embodiment 1.
1 valerian seedling medicine of test example sleep essential oil physicochemical property
Valerian seedling medicine sleep essential oil physicochemical property prepared by 1 Examples 1 to 3 of table
2 valerian seedling medicine of test example sleep essential oil uses rear sensory evaluation
Test method 1：Valerian seedling medicine prepared by Examples 1 to 5 is slept into essential oil respectively by 50 poor sleep patients
(including sleeping less, dreaminess, difficulty falling asleep, Yi Xing, minor depressive person) it is on probation, sensory evaluation is as shown in Figure 1 after trying out 1 time：(each
Point value of evaluation is 10 points, and fraction is higher, and corresponding project feels more apparent, and such as sliding sense is evaluated as 9 points, and it is apparent to illustrate that product slides sense)；
Result of the test：It can be seen that from result figure 1, Examples 1 to 3 has same reflecting feel and sliding sense；But embodiment 4
Sticky sense and the residual sense for giving skin are very strong, hence it is evident that higher than Examples 1 to 3；Embodiment 5 gives sticky sense and the residual of skin
Sense is significantly lower than Examples 1 to 3；Volunteer is more willing to the sample of Examples 1 to 3 on probation.Examples 1 to 3 sensory evaluation is overall
Evaluation is better than embodiment 4 and embodiment 5.
3 valerian seedling medicine of test example sleep essential oil is assessed using rear therapeutic effect
(1) test method：To 210 17 to 80 years old ages not wait poor sleep patient (including sleeping less, dreaminess, sleep
Difficulty, Yi Xing, minor depressive person) January on probation, it massages 2~5 minutes every time, patient is randomly divided into 7 groups, carries out Clinical practice sight
It examines.Grouping situation is as follows
Control group 1：Chinese patent CN103120756A essential oils as made of embodiment 1
Control group 2：Chinese patent CN102755271A essential oils as made of embodiment 1
Test group 1~5：Valerian seedling medicine sleep essential oil prepared by Examples 1 to 5
(2) efficacy assessment standard
It cures：Symptom and sign completely disappears；
Effectively：Symptom and sign mitigates earlier above；
It is invalid：Symptom and sign is preceding without improvement with treatment.
(3) therapeutic effect：It is shown in Table 1
The different essential oils of table 1 are to promoting sleep effect evaluation of clinical curative effect table
Result of the test：It can be seen that from 1 result of table, compared with five groups of embodiments, used the volunteer of embodiment 1,2,3 more
More feedback skin senses profits and it is oiliness, sleep quality has clear improvement after use, and more than 90%, patient is continuing with total effective rate
The desire of this essential oil.The volunteer's feedback skin sense for having used embodiment 4 is irritant, and fragrance overrich is not suitable for promoting sleep；Make
It is fed back with the volunteer of embodiment 5, it is faint without mitigation or mitigation to assisting sleep.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not limited to the substantial technological content of the present invention
Scope, substantial technological content of the invention are broadly to be defined in the right of application, any skill that other people complete
Art or method, if with claims hereof scope defined in a kind of identical or simply equivalent replacement,
It is considered as being covered by among the right.
Claims (9)
- The essential oil 1. a kind of valerian seedling medicine is slept, which is characterized in that be prepared including following raw material by weight percentage：
- The essential oil 2. valerian seedling medicine as described in claim 1 is slept, spy are that the oleic acid/linoleic acid/leukotrienes gathers sweet Grease class, valerian essential oil, Blumea balsamifera essential oil, Fructus Perillae quintessence oil, sandalwood essential oil, the weight percent of thousand layers of chrysanthemum essential oil and Lavender Than the sum of be 100%.
- The essential oil 3. valerian seedling medicine as described in claim 1 is slept, spy are that the sleep essential oil includes following weight percent The raw material of content is prepared：
- 4. preparing the valerian seedling medicine sleep essential oil as described in claim 1 or 3, spy is that preparation method comprises the following steps：(1) prefabricated foundation oilUnder conditions of stirrings, oleic acid/linoleic acid/leukotrienes polyglycereol esters are added in into reactor, are warming up to 55~60 DEG C, It is stirred, is cooled to 40~45 DEG C, stirs evenly, obtain prefabricated foundation oil；(2) essential oil is preparedUnder stirring, valerian essential oil, Blumea balsamifera essential oil, Fructus Perillae quintessence oil are sequentially added into reactor and is stirred evenly, added in Sandalwood essential oil, thousand layers of chrysanthemum essential oil, Lavender, continue to stir, and are uniformly mixed, obtain blend of essential oils；(3) under conditions of stirring, blend of essential oils prepared by step (2) is added in into step (1) prefabricated foundation oil, mixing is equal Even, filtering obtains valerian seedling medicine sleep essential oil.
- 5. preparation method as claimed in claim 4, spy are, the 180~250r/ of rotating speed stirred described in step (1) min；The time being stirred is 3~10min；The time stirred evenly is 8~15min.
- 6. preparation method as claimed in claim 4, spy are, the 150~250r/ of rotating speed stirred described in step (2) min；The time stirred evenly is 3~5min, the time for continuing stirring for 1~3min, time of mixing for 1~ 3min；The temperature of the stirring and mixing is room temperature.
- 7. preparation method as claimed in claim 4, spy are, 250~300r/min of rotating speed of stirring in step (3)；It is mixed The time of conjunction is 8~15min, and the temperature of mixing is room temperature.
- 8. a kind of valerian seedling medicine sleep essential oil is slept in preparation treatment caused by mild or moderate, bad, sleep is not deep, difficulty falling asleep And the application in terms of minor depressive.
- 9. preparation method as claimed in claim 8, spy are, the valerian seedling medicine sleep essential oil application method is：Before sleeping 30 points of kinds take this product to embrocate temple or the related acupuncture point of sleep, daily 1~2 time.
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