CN108042440A - A kind of lotion for having significant curative effect to chapped skin and preparation method thereof - Google Patents
A kind of lotion for having significant curative effect to chapped skin and preparation method thereof Download PDFInfo
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- CN108042440A CN108042440A CN201810130716.1A CN201810130716A CN108042440A CN 108042440 A CN108042440 A CN 108042440A CN 201810130716 A CN201810130716 A CN 201810130716A CN 108042440 A CN108042440 A CN 108042440A
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- 239000006210 lotion Substances 0.000 title claims abstract description 64
- 230000000694 effects Effects 0.000 title claims abstract description 23
- 206010040849 Skin fissures Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 241001494479 Pecora Species 0.000 claims abstract description 24
- 241000218989 Trichosanthes Species 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims description 28
- 239000013049 sediment Substances 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 22
- 241000196324 Embryophyta Species 0.000 claims description 18
- 239000006228 supernatant Substances 0.000 claims description 16
- 238000002137 ultrasound extraction Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 239000007787 solid Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 13
- 238000005119 centrifugation Methods 0.000 claims description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 210000002683 foot Anatomy 0.000 description 96
- 208000024891 symptom Diseases 0.000 description 77
- 238000012360 testing method Methods 0.000 description 21
- 238000000034 method Methods 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 206010013786 Dry skin Diseases 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 208000034158 bleeding Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000037336 dry skin Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000005336 cracking Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 229940099259 vaseline Drugs 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 241001573881 Corolla Species 0.000 description 1
- 241000893536 Epimedium Species 0.000 description 1
- 241001362051 Epimedium rhizomatosum Species 0.000 description 1
- 241001091433 Itea Species 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 241001251761 Riparia Species 0.000 description 1
- 241000220151 Saxifragaceae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 235000008326 Trichosanthes anguina Nutrition 0.000 description 1
- 244000078912 Trichosanthes cucumerina Species 0.000 description 1
- 241000046498 Trichosanthes dunniana Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- -1 resin acid ester Chemical class 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
A kind of lotion for having significant curative effect to chapped skin of the present invention and preparation method thereof, is formulated by the raw material of following portions by weight：90 130 parts of the petal of Trichosanthes duwnana levl, 230 270 parts of the blade of riverbank mouse thorn, 300 350 parts of the pulp of the excessive sheep case of strong stem, 50 parts of propylene glycol, 550 parts of water, the lotion is obtained by a series of preparation processes, smear subject's foot, daily morning and evening respectively once, each 5ml moisturizing amounts of moisture, it is massaged into absorption, First Year started to smear May 1, to second year cut-off on May 1, period is not smeared at subject's foot breach, subject's foot chap situation is clearly better, without breach bleeding, the lotion has efficacy stability, it does not rebound, it is evident in efficacy, the advantages that preparation process is simple.
Description
Technical field
The invention belongs to skin care industries, are related to a kind of lotion for having significant curative effect to chapped skin and preparation method thereof.
Background technology
Chap refers to hand and foot dry skin and crackle as caused by a variety of causes, and with pain, severe patient can influence day
Normal live and work.This disease is both some dermopathic simultaneous phenomenons and a kind of independent skin disease.After it is cold, originally
Delicate skin can become dry, coarse, the position that especially metapedes often rubs, it is also possible to dry fracture occur, pain goes out
The phenomenon that blood, can also interfere activity and work when serious.Winter climate is cold and dries, as northwest blows air over, the hand of people
Foot is switched to coarse by moistening, if be not protected by, breach easily occurs, severe patient can also cause pain, bleeding, medically claim
Its " fissura ".Although the prior art has outer the applying the ointment of improvement chap, but can only take stopgap measures cannot effect a permanent cure, when coating, disease
The defects of shape may be alleviated, but once stop coating, and symptom can restore again, this is the prior art.
The content of the invention
It is an object of the invention to overcome the prior art existing weak curative effect, side effect in terms of foot chap is nursed big,
And the deficiency of secondary injury is easily brought to patient, and provide it is a kind of using it is easy, safe and reliable, at low cost, curative effect is apparent, spy
It is not for lotion of foot chap and preparation method thereof.
The object of the present invention is achieved like this：
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
90-130 parts of the petal of Trichosanthes duwnana levl, 230-270 parts of the blade of riverbank mouse thorn, the pulp 300- of the strong excessive sheep case of stem
350 parts, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) the petal 90-130 parts by weight of Trichosanthes duwnana levl, the blade 230-270 parts by weight of riverbank mouse thorn, the strong excessive sheep of stem are taken
The pulp 300-350 parts by weight of case are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
In the present invention, three kinds of plants are organized as major function additive：Trichosanthes duwnana levl (Classification system：Trichosanthes
Dunniana Levl.) it is that Curcurbitaceae snake gourd rattan shape climbs up by holding on to draft, raceme axillary is 8-10 centimetres long, corolla pale red,
The month at florescence 7-9, the Trichosanthes duwnana levl petal used in of the invention pick up from Zhenfeng, Guizhou；Riverbank mouse thorn (Classification system：Itea
Riparia Coll.et Hemsl.) it is that Saxifragaceae mouse thorn belongs to shrub, the thin keratin of leaf is usually intensive at branch end, and ovate of falling is long
Ellipse, ellipse to lanceolar, 5-10 centimetres long, 1.5-3 centimetres wide, the riverbank mouse thorn blade used in the present invention picks up from cloud
On southern Xishuangbanna river bank humidity rock；The excessive sheep case (Classification system of strong stem：Epimedium rhizomatosum Stearn)
It is Berberidaceae Epimedium perennial herb, plant is 38-42 centimetres high, and capsule is about 25 millimeters, fruiting period July, is used in the present invention
To the excessive sheep case pulp of strong stem pick up from the mountain of Sichuan in shrubbery.Collection raw material-pretreatment and store method are the prior art, this field skill
Art personnel, which answer, to be known.
The centrifuge brand used in the present invention reaches to be triumphant, and model DL7M-12L has purchased from Hunan is triumphant up to scientific instrument
Limit company；The ultrasonic extraction instrument brand used in the present invention be the sky, model TCX-350G/S, purchased from Jining sky ultrasonic machine
Tool equipment Co., Ltd.Grinding method, stirring means, centrifugation technique and the ultrasound assisted extraction technique used in the present invention are existing
Technology, those skilled in the art should know.
Properties of product evaluation test of the present invention is as follows：
First, skin irritation test：
2.5~3kg healthy rabbits 80 are selected, every rabbit back is symmetrical to select shaving 2.5cm at 202, it is right with itself
According to test method(s) carry out, every time apply 1g products of the present invention, twice daily, left or right side is smeared at random, observe and record for 24 hours, 72h
The reacting phenomenon of skin afterwards.
The result shows that：It applies product of the present invention and has no that the local excitations such as rubefaction, dermexanthesis, water lump are reacted for 24 hours, after 72h, say
Bright lotion of the present invention is to be perfectly safe, without any adverse reactions.
2nd, efficacy validation
According to being divided in the prior art to the nbjective symptom standard that foot is chapped, four degree are generally can be divided into：
Zero degree：For dry skin without chap, the symptoms such as no bleeding, pain are basically identical with healthy skin.
Once：Dry skin has chap, but only up to epidermis, therefore without symptoms such as bleeding, pain.
Two degree：Dry skin, crack gos deep into corium by epidermis and has slight shouting pain, but does not cause bleeding.
Three degree：Dry skin, crack gos deep into corium and subcutaneous tissue by epidermis, often causes bleeding and touches a tender spot or cusalgia.
360 foots is selected to have 35-65 Sui volunteer of three degree of fissuras, the wherein age is the volunteer 120 of 35-45 Sui
People, each 60 people of men and women, 120 people of volunteer of 46-55 Sui age bracket, each 60 people of men and women, the volunteer 120 of 56-65 Sui age bracket
People, each 60 people of men and women, test site are Nanchang City, Jiangxi Province, and more than volunteer is by the hospital dermatology department of Nanchang City, Jiangxi Province ten
Expert checks and complies with standard and select, and without disease and bad habit, is divided into 12 groups, and 11 groups are test group, and one group is control group,
Every group of 30 people, every group all comprising 35-45 Sui, 46-55 Sui, 56-65 Sui age bracket, per each 5 people of age bracket men and women, control group use
Product is applied to entire chap foot during on-test, sooner or later respectively by common vaseline hand lotion, test group product of the present invention
Once, each dosage is the product of 5ml, when smearing answer it is light and slow be massaged into absorptions, do not applied if meeting volunteer's pedal skin and cracking
Cracking position is smeared, other positions still use.On May 1st, 2013 begins to use, until on May 1st, 2014 ended, in 2014 1
The moon 30, on January 30th, 2015, the chap symptom for observing volunteer respectively on January 30th, 2016 are simultaneously recorded by standard division, with
It is compared before experiment.In addition, the custom that the diet during experiment is worked and rested according to volunteer in itself usually, deliberately will not make
It asks, if personnel's generation major disease or other accidents can not continue experiment during experiment, the experiment of the people should be stopped,
Other staff carry out as usual.
Specific embodiment
Embodiment 1-11 is test group, and embodiment 12 is control group, 30 people of number is tested per embodiment, every group all includes
35-45 Sui, 46-55 Sui, 56-65 Sui age bracket, per each 5 people of age bracket men and women, the common vaseline hand lotion of control group, experiment
Product is applied to entire chap foot during on-test by group product of the present invention, and once in the morning and once at night, each dosage is 5ml's
Product, when smearing answer it is light and slow be massaged into absorption, do not smear cracking position if volunteer's pedal skin cracking is met, other positions according to
Old use.On May 1st, 2013 begins to use, until on May 1st, 2014 end, on January 30th, 2014, on January 30th, 2015,
The chap symptom of volunteer is observed respectively on January 30th, 2016 and by standard division record, with being compared before experiment.In addition, examination
The custom that diet during testing is worked and rested according to volunteer in itself usually, does not require deliberately, if personnel send out during experiment
Raw major disease or other accidents can not continue experiment, should stop the experiment of the people, and other staff carry out as usual.Below
The invention will be further described in conjunction with specific embodiments：
Embodiment 1
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
90 parts of the petal of Trichosanthes duwnana levl, 240 parts of the blade of riverbank mouse thorn, 350 parts of the pulp of the strong excessive sheep case of stem, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 90 parts by weight of petal of Trichosanthes duwnana levl, 240 parts by weight of blade of riverbank mouse thorn, the pulp of the strong excessive sheep case of stem are taken
350 parts by weight are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：2 people's foots chap symptom as zero degree, 26 people's foots chap symptom
For once, 2 people's foots chap symptom is two degree；On January 30th, 2015 observes result：26 people's foots chap symptom is once 4 people
Foot chap symptom is two degree；On January 30th, 2016 observes result：25 people's foots chap symptom is once 5 people's foot fissuras
Shape is two degree.
Embodiment 2
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
130 parts of the petal of Trichosanthes duwnana levl, 260 parts of the blade of riverbank mouse thorn, 300 parts of the pulp of the strong excessive sheep case of stem, water 550
Part.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 130 parts by weight of petal of Trichosanthes duwnana levl, 260 parts by weight of blade of riverbank mouse thorn, the pulp of the strong excessive sheep case of stem are taken
300 parts by weight are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：2 people's foots chap symptom as zero degree, 27 people's foots chap symptom
For once, 1 people's foot chap symptom is two degree；On January 30th, 2015 observes result：27 people's foots chap symptom is once 3 people
Foot chap symptom is two degree；On January 30th, 2016 observes result：27 people's foots chap symptom is once 3 people's foot fissuras
Shape is two degree.
Embodiment 3
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
100 parts of the petal of Trichosanthes duwnana levl, 250 parts of the blade of riverbank mouse thorn, 320 parts of the pulp of the strong excessive sheep case of stem, water 550
Part.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 100 parts by weight of petal of Trichosanthes duwnana levl, 250 parts by weight of blade of riverbank mouse thorn, the pulp of the strong excessive sheep case of stem are taken
320 parts by weight are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：1 people's foot chaps symptom as zero degree, 27 people's foots chap symptom
For once, the chap of 2 people's foots is two degree of symptom；On January 30th, 2015 observes result：27 people's foots chap symptom is once 3 people
Foot chap symptom is two degree；On January 30th, 2016 observes result：26 people's foots chap symptom is once 4 people's foot fissuras
Shape is two degree.
Embodiment 4
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
120 parts of the petal of Trichosanthes duwnana levl, 230 parts of the blade of riverbank mouse thorn, 340 parts of the pulp of the strong excessive sheep case of stem, glycerine is hard
65 parts of resin acid ester, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 120 parts by weight of petal of Trichosanthes duwnana levl, 230 parts by weight of blade of riverbank mouse thorn, the pulp of the strong excessive sheep case of stem are taken
340 parts by weight are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：3 people's foots chap symptom as zero degree, 25 people's foots chap symptom
For once, 2 people's foots chap symptom is two degree；On January 30th, 2015 observes result：26 people's foots chap symptom is once 4 people
Foot chap symptom is two degree；On January 30th, 2016 observes result：26 people's foots chap symptom is once 4 people's foot fissuras
Shape is two degree.
Embodiment 5
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
110 parts of the petal of Trichosanthes duwnana levl, 270 parts of the blade of riverbank mouse thorn, 310 parts of the pulp of the strong excessive sheep case of stem, water 550
Part.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 110 parts by weight of petal of Trichosanthes duwnana levl, 270 parts by weight of blade of riverbank mouse thorn, the pulp of the strong excessive sheep case of stem are taken
310 parts by weight are fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：2 people's foots chap symptom as zero degree, 27 people's foots chap symptom
For once, 1 people's foot chap symptom is two degree；On January 30th, 2015 observes result：28 people's foots chap symptom is once 2 people
Foot chap symptom is two degree；On January 30th, 2016 observes result：26 people's foots chap symptom is once 4 people's foot fissuras
Shape is two degree.
Embodiment 6
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
90 parts of the petal of Trichosanthes duwnana levl, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 90 parts by weight of petal of Trichosanthes duwnana levl are taken, is fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtains pureed
Object, it is spare；
(2) purees for obtaining (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with the speed of 10000r/min
Degree centrifugation 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：16 people's foots chap symptom is once 14 people's foot fissuras
Shape is two degree；On January 30th, 2015 observes result：14 people's foots chap symptom is once, 16 people's foots chap symptom is two degree；
On January 30th, 2016 observes result：11 people's foots chap symptom is once, 12 people's foots chap symptom is two degree, 7 people's foot chaps
Symptom is split for three degree.
Embodiment 7
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
240 parts of the blade of riverbank mouse thorn, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 240 parts by weight of blade of riverbank mouse thorn are taken, is fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtains pureed
Object, it is spare；
(2) purees for obtaining (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with the speed of 10000r/min
Degree centrifugation 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：17 people's foots chap symptom is that once, the chap of 13 people's foots is
Two degree；On January 30th, 2015 observes result：15 people's foots chap symptom is once, the chap of 11 people's foots is two degree, 4 people's foots
Symptom of chapping is three degree；On January 30th, 2016 observes result：14 people's foots chap symptom is once 10 people's foots chap symptom
For two degree, 6 people's foots chap symptom is three degree.
Embodiment 8
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
350 parts of the pulp of the excessive sheep case of strong stem, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 350 parts by weight of pulp of the excessive sheep case of strong stem are taken, is fully ground in the environment of 20 DEG C -25 DEG C of room temperature, obtains mud
Shape object, it is spare；
(2) purees for obtaining (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with the speed of 10000r/min
Degree centrifugation 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：18 people's foots chap symptom is that once, the chap of 12 people's foots is
Two degree；On January 30th, 2015 observes result：17 people's foots chap symptom is once, the chap of 11 people's foots is two degree, 2 people's foots
Symptom of chapping is three degree；On January 30th, 2016 observes result：13 people's foots chap symptom is once 12 people's foots chap symptom
For two degree, 5 people's foots chap symptom is three degree.
Embodiment 9
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
90 parts of the petal of Trichosanthes duwnana levl, 240 parts of the blade of riverbank mouse thorn, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 90 parts by weight of petal of Trichosanthes duwnana levl are taken, 240 parts by weight of blade of riverbank mouse thorn, in 20 DEG C -25 DEG C of room temperature
It is fully ground in environment, obtains pureed mixture, it is spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：21 people's foots chap symptom is once, the chap of 9 people's foots is two
Degree；On January 30th, 2015 observes result：18 people's foots chap symptom is once, the chap of 11 people's foots is two degree, 1 people's foot chap
Symptom is split for three degree；On January 30th, 2016 observes result：14 people's foots chap symptom is that once, 12 people's foots chap symptom is
Two degree, 4 people's foots chap symptom is three degree.
Embodiment 10
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
90 parts of the petal of Trichosanthes duwnana levl, 350 parts of the pulp of the strong excessive sheep case of stem, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 90 parts by weight of petal of Trichosanthes duwnana levl are taken, 350 parts by weight of pulp of the strong excessive sheep case of stem, in 20 DEG C -25 DEG C of room temperature
Environment in be fully ground, obtain pureed mixture, it is spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：20 people's foots chap symptom is that once, the chap of 10 people's foots is
Two degree；On January 30th, 2015 observes result：16 people's foots chap symptom is once, the chap of 12 people's foots is two degree, 2 people's foots
Symptom of chapping is three degree；On January 30th, 2016 observes result：14 people's foots chap symptom is once 13 people's foots chap symptom
For two degree, 3 people's foots chap symptom is three degree.
Embodiment 11
A kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
240 parts of the blade of riverbank mouse thorn, 350 parts of the pulp of the strong excessive sheep case of stem, 550 parts of water.
A kind of method for preparing lotion, it is characterised in that comprise the following steps：
(1) 240 parts by weight of blade of riverbank mouse thorn are taken, 350 parts by weight of pulp of the strong excessive sheep case of stem, in 20 DEG C -25 of room temperature
DEG C environment in be fully ground, obtain pureed mixture, it is spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with 10000r/min
Speed centrifuge 15 minutes, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, temperature be 50 DEG C, frequency is 40KHz's
Under the conditions of ultrasonic extraction 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid is cooled to 25 DEG C to get the lotion.
Result of the test：On January 30th, 2014 observes result：22 people's foots chap symptom is once, the chap of 8 people's foots is two
Degree；On January 30th, 2015 observes result：19 people's foots chap symptom is once, the chap of 8 people's foots is two degree, the chap of 3 people's foots
Symptom is three degree；On January 30th, 2016 observes result：16 people's foots chap symptom is once, 10 people's foots chap symptom is two
Degree, 4 people's foots chap symptom is three degree.
Embodiment 12
The present embodiment is control group, and it is common vaseline hand lotion that volunteer, which smears,.
Result of the test：On January 30th, 2014 observes result：3 people's foots chap symptom is once, the chap of 20 people's foots is two
Degree, 7 people's foots chap symptom is three degree；On January 30th, 2015 observes result：2 people's foots chap symptom is two degree, 28 people's foots
Symptom of chapping is three degree；On January 30th, 2016 observes result：30 people's foots chap symptom is three degree.
Claims (2)
1. a kind of lotion for having significant curative effect to chapped skin, it is characterised in that the lotion includes the original of following parts by weight
Material：
120 parts of the petal of Trichosanthes duwnana levl, 230 parts of the blade of riverbank mouse thorn, 340 parts of the pulp of the strong excessive sheep case of stem, glycerol stearate
65 parts of ester, 550 parts of water；
And making step is as follows：
(1) 120 parts by weight of petal of Trichosanthes duwnana levl, 230 parts by weight of blade of riverbank mouse thorn, the pulp 340 of the strong excessive sheep case of stem are taken
Parts by weight are fully ground in the environment of 25 DEG C or so of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with the speed of 10000r/min
Degree centrifugation 15 minutes, abandoning supernatant, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, in the condition that temperature is 50 DEG C, frequency is 40KHz
Lower ultrasonic extraction about 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid leaves plant tissue mixed liquor, is cooled to 25 DEG C or so to get the lotion.
2. a kind of preparation method for the lotion for having significant curative effect to chapped skin, it is characterised in that including following preparation process：
(1) 120 parts by weight of petal of Trichosanthes duwnana levl, 230 parts by weight of blade of riverbank mouse thorn, the pulp 340 of the strong excessive sheep case of stem are taken
Parts by weight are fully ground in the environment of 25 DEG C or so of room temperature, obtain pureed mixture, spare；
(2) the pureed mixture obtained (1) step and 600 parts by weight absolute ethyl alcohol and stirring mixings, with the speed of 10000r/min
Degree centrifugation 15 minutes, abandoning supernatant, abandoning supernatant stays sediment spare；
(3) 550 parts by weight water are added in the sediment for obtaining (2) step, in the condition that temperature is 50 DEG C, frequency is 40KHz
Lower ultrasonic extraction about 45 minutes, then 100 DEG C of water-baths, keep 8 it is small when after solid residue is filtered off, leave plant tissue mixing
Liquid leaves plant tissue mixed liquor, is cooled to 25 DEG C or so to get the lotion.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810130716.1A CN108042440A (en) | 2018-02-08 | 2018-02-08 | A kind of lotion for having significant curative effect to chapped skin and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810130716.1A CN108042440A (en) | 2018-02-08 | 2018-02-08 | A kind of lotion for having significant curative effect to chapped skin and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113057919A (en) * | 2021-04-01 | 2021-07-02 | 广州花瓷颜化妆品有限公司 | Skin-moistening natural petal water and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406839A (en) * | 2011-06-20 | 2012-04-11 | 洪长征 | Soaking agent for beriberi and rhagadia manus et pedis |
| CN103070961A (en) * | 2013-02-04 | 2013-05-01 | 山西振东家庭健康护理用品有限公司 | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof |
| CN103237555A (en) * | 2010-02-19 | 2013-08-07 | 玫琳凯有限公司 | Topical skin care formulation |
-
2018
- 2018-02-08 CN CN201810130716.1A patent/CN108042440A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103237555A (en) * | 2010-02-19 | 2013-08-07 | 玫琳凯有限公司 | Topical skin care formulation |
| CN102406839A (en) * | 2011-06-20 | 2012-04-11 | 洪长征 | Soaking agent for beriberi and rhagadia manus et pedis |
| CN103070961A (en) * | 2013-02-04 | 2013-05-01 | 山西振东家庭健康护理用品有限公司 | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113057919A (en) * | 2021-04-01 | 2021-07-02 | 广州花瓷颜化妆品有限公司 | Skin-moistening natural petal water and preparation method thereof |
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Application publication date: 20180518 |