CN108030675A

CN108030675A - A kind of medical treatment art for coating

Info

Publication number: CN108030675A
Application number: CN201711311759.1A
Authority: CN
Inventors: 陈晓盛
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-11
Filing date: 2017-12-11
Publication date: 2018-05-15

Abstract

The invention discloses a kind of medical art for coating,（1）Manufacture bag paddle：Talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica are mixed to prepare bag paddle；（2）Preheat tablet：Tablet is placed in coating equipment in sugar production line, hot gas is sprayed into coating equipment in sugar production line by the air jet system arranged on coating equipment in sugar production line bottom, is heated up to coating equipment in sugar production line inside to heat tablet；（3）Coating.Hydroxypropyl methyl cellulose and nanometer grade silica are added in the bag paddle of the present invention, not only so that coating is with good moisture-proof, anti-oxidation, etch-proof characteristic, tablet is effectively kept the situation aoxidize, make moist, going bad, the stability for improving tablet of high degree occur；The speed that the pharmacological property of tablet outwards discharges can also be slowed down, avoid user from situation about having a stomach upset occur.

Description

A kind of medical treatment art for coating

Technical field

The invention belongs to field of feed additive technology, more particularly, to a kind of medical art for coating.

Background technology

In pharmaceuticals industry, generally tablet can be protected, prevented in the one layer of coating of tablet outer cladding, this layer coating Only tablet chip oxidation deterioration, make moist or volatilize, and can hidden cover core piece take the taste of discomfort, reach tablet easy to identification and relax Molten in human body stomach such as releases at the effect.

But existing coating generally use talcum powder is made, and moisture-proof, the oxidation resistant effect of its obtained coating is poor, Tablet is difficult to reach the effect of good moisture-proof anti-metamorphic after being coated.

The content of the invention

The present invention is of good performance in order to overcome the deficiencies of the prior art and provide the moisture-proof anti-metamorphic of tablet after a kind of coating Medical art for coating.

To achieve these goals, the present invention uses following technical scheme：A kind of medical treatment art for coating, including following step Suddenly：

（1）Manufacture bag paddle：Talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica are mixed to prepare bag paddle；

（2）Preheat tablet：Tablet is placed in coating equipment in sugar production line, by the air jet system arranged on coating equipment in sugar production line bottom to coating equipment in sugar production line Middle penetrating hot gas, heats up coating equipment in sugar production line inside to heat tablet；

（3）Coating：Coating equipment in sugar production line bottom is equipped with spray gun, is sent bag paddle in spray gun and by spray gun by feeding part and sprayed upwards Go out；Meanwhile the upward jet of air jet system so that tablet has been sprayed and freely falling body, and the coating realized to tablet is contacted with bag paddle.

Bag paddle in the present invention is mixed using talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica, due to Nanometer grade silica has good moisture resistance, heat resisting corrosion-proof corrosion and inoxidizability, so as to pass through nanometer grade silica Addition, may be such that the coating finally obtained with good moisture-proof, anti-oxidation, etch-proof characteristic, and then can effectively keep There is the situation aoxidize, make moist, going bad, the stability for improving tablet of high degree in tablet；Secondly, nano level material is also The glossiness of coating can effectively be strengthened so that final obtained tablet outer surface has good glossiness；Hydroxypropyl methyl is fine Dimension element has the function that the good pharmacological property for slowing down tablet outwards discharges, and discharges too fast and stomach is sticked so as to can effectively avoid medicament Film causes excessive stimulation, avoids user from situation about having a stomach upset occur；Pass through hydroxypropyl methyl cellulose and nanoscale two Silica uses at the same time, in the case where ensureing that tablet stability is strong, while realizes the slow release of tablet.

Further, the ratio of weight and number between the talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica is 2-4：1.5-2.5:1.3-1.6；Under this kind of ratio, talcum powder can fully play the role of anti-stick, ensure that mixing is equal Be not in cohesive situation after even, between hydroxypropyl methyl cellulose, nanometer grade silica, so that after ensureing tablet coating Uniformity of distribution on outer surface, has stronger stability.

Further, the ratio of weight and number between the talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica is 3：1.1:0.96.

Further, in preheating step, the temperature in the coating equipment in sugar production line maintains 50-55 DEG C；The air jet system The gas temperature of injection is 55-58 DEG C, jet velocity 1-2L/h；When the internal temperature of coating equipment in sugar production line is less than 50 DEG C, tablet Outer layer be difficult to be softened so that when being coated in the later stage, the adhesive force of bag paddle is poor, influences the coating effect in later stage；And when temperature When degree is more than 55 DEG C, although tablet outer layer can obtain good softening, also received inside tablet a degree of soft Change, so that drying to tablet can be realized by needing to carry out drying for a long time in drying steps after coating so that work It is low to make efficiency, energy consumption is very big；And when the temperature in coating equipment in sugar production line maintains 50-55 DEG C, it is good both to have can guarantee that tablet outer layer was subject to Good softening, and can guarantee that and will not be influenced inside tablet by morely, so that in the case where ensureing good adhesive force, and energy Ensure work efficiency, realize state the most energy saving；And the gas temperature for working as the injection of air jet system is less than 55 DEG C, jet velocity During less than 1L/h, the speed that hot gas sprays into will be less than the speed of coating equipment in sugar production line cooling, so as to be difficult to maintain the temperature in coating equipment in sugar production line Degree is maintained in 50-55 DEG C；When air jet system injection gas temperature be higher than 58 DEG C, when jet velocity be higher than 2L/h, be coated Programming rate in equipment again can be too fast, so that the temperature in coating equipment in sugar production line is higher than 55 DEG C；Proved after overtesting, work as spray The gas temperature of the injection of device of air maintains 55-58 DEG C, when jet velocity maintains 1-2L/h, can keep in coating equipment in sugar production line All the time maintain in the range of 50-55 DEG C.

Further, the coating equipment in sugar production line includes operating room, spray gun, air jet system, feed arrangement and retracting device；It is described Spray gun is arranged on operating room bottom, the air jet system include being sheathed on the sleeve outside spray gun, the jet channel in sleeve and The jet member being connected with jet channel；The jet member is to be obliquely installed；Due to jet member to be obliquely installed, and between jet member Incline direction in the same direction set；The retracting device includes being communicated in the recovery channel of the operating room bottom, arranged on recycling Primary outlet and secondary outlet on pipeline.In the use of the present invention, rotation can be formed via the gas that jet member sprays Stream, so that during material has been sprayed upwards, enables to capsule core that rotation occurs during upthrow, so that bag Clothing is more uniformly distributed, so that compound the more uniformly spreading outside tablet in bag slurry, part should not occurs and make moist, go bad Situation, the stability higher of tablet；Secondly as gas is eddy flow, so that running orbit of the capsule core during upthrow is Helical form, so that the time stayed aloft is longer, the time contacted with packaging material is grown, and coating effect is more preferable；Furthermore due to gas The effect of eddy flow so that capsule core will be rotated around the outer circle of nozzle under the influence of centrifugal force, during capsule core is by upthrow, Not the problem of not having capsule core to be tossed from nozzle present position, many packaging materials locally coated from without capsule core so that The coating of capsule core outer surface is uniform, so as to effectively prevent the problem of tablet composition is unstable；Meanwhile coating is uniform so that tablet Rate of release is uniform in gastric juice, effectively protects the intestinal health of people；By primary outlet and level outlet to material into The secondary collection of row, ensures no longer to remain powder in discharged hot gas, powder separation rate is high.

Further, the spray gun includes gun barrel and atomizer, and the atomizer includes head body, charging is led to Road, the first atomization chamber arranged on head body top and the second atomization chamber and the 3rd atomization that are symmetrically set in head body sidepiece Chamber；First atomization chamber, the second atomization chamber and the 3rd atomization chamber pass through a spray main channel and the feeding-passage phase respectively Connection；It is atomized respectively by three atomization chambers, it is non-interference between each atomization chamber, so as to compare the spray on whole nozzle For hole connects the situation of same atomization chamber, the pressure bigger of the liquid in atomization chamber, so that liquid is from spray orifice Jet power bigger during ejection, atomizing effect is good, improves dry efficiency.

Further, the spray main channel inner wall is equipped with spiral helicine drainage track；By by spray main channel Wall is arranged to helical form so that liquid is in whirlpool state when spraying and circulating in main channel, so that liquid is released into atomization chamber Impact force when interior is substantially increased, and further lifts the atomizing effect of nozzle.

Further, it is respectively equipped with primary atomization component in first atomization chamber, the second atomization chamber and the 3rd atomization chamber With secondary atomization component, there is spacing to be formed for medium injection and divided between the primary atomization component and secondary atomization component The atomization space to scatter；Space before both can ensure the spray film gone out via primary atomization component atomized spray, can be in hair On the injection of bulk to secondary atomization component, hit substantially in droplet-like to secondary atomization component, prevent the liquid ejected It is injected into fluid column on secondary atomization component, so that droplet can disperse rapidly after the processing of secondary atomization component Into the mist pearl of minor diameter, good atomizing effect is realized.

Further, the primary atomization component includes primary atomization plate, in the primary atomization plate central part Heart passage and the edge gateway arranged on the primary atomization edges of boards edge one circle, the spacing between neighboring edge passage is equal, described Central passage is equipped with spiral helicine impact tracks with the edge gateway inner wall；The setting of impact tracks, realizes liquid and exists Dual cyclone effect in nozzle, ensures that impact force of the liquid in atomization reaches maximum；It is divided into central passage and edge leads to Road, the distribution of passage is more scattered, so that passage, when spraying liquid, the space that liquid has bigger is disperseed, and is not in Mutually hit the situation for offsetting impact force.

Further, the secondary atomization component includes secondary atomization plate and multiple mists on the secondary atomization plate Change spray orifice group, the position of central passage and edge gateway described in the position of the atomization spray orifice group is corresponding；The atomization spray orifice Group is the multiple orifices annularly set；Due to the liquid that passage sprays, after outwards disperseing, it is usually annular；So as to Orifice is annularly set, can preferably correspond to the position for liquid, ensures that liquid is in maximum for the impact force of orifice State, so as to reach good atomizing effect so that the drying effect of product is good.

Further, the orifice inner wall has rough layer, and it is raised that the rough layer is equipped with some reinforcements；Pass through protrusion Set, can be broken up to carrying out cutting via the liquid sprayed in orifice, ensure good atomizing effect.

In conclusion the present invention has the following advantages：Hydroxypropyl methyl cellulose and nanoscale dioxy are added in bag paddle SiClx, not only so that coating is with good moisture-proof, anti-oxidation, etch-proof characteristic, effectively keep tablet occur oxidation, by Tide, rotten situation, the stability for improving tablet of high degree；The speed that the pharmacological property of tablet outwards discharges can also be slowed down Degree, avoids user from situation about having a stomach upset occur.

Brief description of the drawings

Fig. 1 is the structure diagram of the present invention.

Fig. 2 is the structure diagram of middle sleeve of the present invention.

Fig. 3 is the structure diagram of atomizer of the present invention.

Fig. 4 is the structure diagram of primary atomization component of the present invention.

Fig. 5 is the structure diagram of secondary atomization component of the present invention.

Fig. 6 is the enlarged drawing at B in Fig. 4.

Fig. 7 is the top view of secondary atomization plate of the present invention.

Embodiment

In order to make those skilled in the art be better understood from the present invention program, below in conjunction with the embodiment of the present invention Attached drawing, carries out the technical solution in the embodiment of the present invention clear, complete description.

Embodiment 1

A kind of medical treatment art for coating, comprises the following steps：（1）Manufacture bag paddle：By talcum powder, hydroxypropyl methyl cellulose, nanometer Grade silicon dioxide is mixed to prepare bag paddle in mixer, wherein the talcum powder, hydroxypropyl methyl cellulose, nanoscale titanium dioxide Ratio of weight and number between silicon is 2：1.5:1.3；Specially take 20kg talcum powder, the hydroxypropyl methyl cellulose of 15kg, 1.3kg Nanometer grade silica be mixed to get；（2）Preheat tablet：Tablet to be coated is placed in coating equipment in sugar production line, such as Fig. 1-7 institutes Show, the coating equipment in sugar production line includes operating room 1, spray gun 4, air jet system 2, feed arrangement 3 and retracting device 5；The spray gun 4 is arranged on 1 bottom of operating room, the air jet system 2 include being sheathed on the sleeve 21 outside spray gun, the jet channel in sleeve and jet The jet member 23 and air blower 24 that passage is connected, are arranged on a heating member 25, the heating member 25 between the air blower 24 and sleeve 21 It is connected respectively by hose with air blower 24 and sleeve 21, the heating member is the heater directly bought on the market；The spray Part 23 is penetrated to be obliquely installed；1 bottom of operating room is equipped with blocking cylinder 11,11 lower part of blocking cylinder and 1 bottom wall of operating room Between be equipped with charging gap；During coating, hot gas is sprayed into coating equipment in sugar production line by the air jet system arranged on coating equipment in sugar production line bottom, it is right Heat up inside coating equipment in sugar production line；Specifically, the gas temperature of the air jet system injection is 55 DEG C, jet velocity 1L/h, So that the constant temperature in coating equipment in sugar production line maintains 50 DEG C, tablet is heated；（3）Coating：Coating equipment in sugar production line bottom is equipped with spray Rifle, bag paddle is sent in spray gun and by spray gun spray upwards by feeding part；Meanwhile the upward jet of air jet system so that Tablet has been sprayed and freely falling body, and the coating realized to tablet is contacted with bag paddle.

Specifically, as shown in figs. 1-7, the feed arrangement 2 is the peristaltic pump directly bought on the market, the feed arrangement 2 It is connected by hose with spray gun 4；The spray gun 4 includes gun barrel and the atomizer for being connected to gun barrel upper end, as shown in fig. 3 to 7, The atomizer includes head body 41, feeding-passage 42, the first atomization chamber 43, the second atomization chamber 44 and the 3rd atomization chamber 45；The feeding-passage 42 is arranged on 41 center of head body, which is connected with the feed arrangement 2 It is logical；First atomization chamber 43 is arranged on head body top, and 44 and the 3rd atomization chamber 45 of the second atomization chamber is located at the first mist Change the lower section of chamber 43, and position correspondence is in head body sidepiece；Wherein the second atomization chamber 44 is arranged to 2, and the 3rd atomization chamber 45 is set It is set to 2；Preferably, the second atomization chamber 44 and the 3rd atomization chamber 45 are symmetrical set along the central axis of head body.

First atomization chamber 43, the second atomization chamber 44 and the 3rd atomization chamber 45 pass through a spray main channel 46 and institute respectively Feeding-passage 42 to be stated to be connected, it is preferred that spray 46 inner wall of main channel is equipped with spiral helicine drainage track 461, specifically, The drainage track 461 is the spiral helicine groove on spray 46 inner wall of main channel；In order to strengthen atomizing effect, institute State in the first atomization chamber 43, the second atomization chamber 44 and the 3rd atomization chamber 45 and be respectively equipped with primary atomization component 47 and secondary atomization portion Part 48, and there is spacing between the primary atomization component 47 and secondary atomization component 48, so as to form atomization space 49 so that It when medium is ejected from primary atomization component 47, can spread out, then hit to secondary atomization component 48, atomizing effect More preferably.

Specifically, as shown in figure 4, the primary atomization component 47 include being installed in primary atomization plate 471 in atomization chamber, Arranged on the central passage 472 of the cylindricality of the primary atomization plate central part and the edge gateway 473 of cylindricality, the edge gateway 473 are arranged to multiple, are arranged on primary atomization plate upper surface and are with central passage 472 close to edge, multiple edge gateways 473 The center of circle is set around the outer circle of central passage 472, and the spacing between neighboring edge passage is equal；As preference, the center Passage 472 on the edge gateway 473 with being equipped with impact tracks 474, specifically, during the impact tracks 474 is set respectively The spiral helicine groove of 473 inner wall of heart passage 472 and the edge gateway.

Specifically, as illustrated in figs. 5-7, the secondary atomization component 48 includes the secondary atomization plate being installed in atomization chamber 481 and multiple atomization spray orifice groups 482 on the secondary atomization plate, the position of the atomization spray orifice group leads to the center The position of road 472 and edge gateway 473 corresponds；Further, the atomization spray orifice group 482 is multiple orifices 483, this A little orifices 483 form a circle so as to form an annular, and the spacing between adjacent orifice 483 is equal；In order to strengthen mist Change effect, we are provided with rough layer 484 in 483 inner wall of orifice, specifically, it is coarse that the rough layer 484, which is surface, The rubber layer of setting；Further, it is evenly spaced in the rubber layer to be provided with multiple reinforcement protrusions 485.

The retracting device 5 is first including the recovery channel 51 with being connected at the top of the operating room, on recovery channel Level outlet 52 and secondary outlet 53；Specifically, the primary outlet 52 is the whirlwind discharger directly bought on the market； The secondary outlet 53 includes discharge chamber 531 and the Blowing stopper arranged on discharge chamber lower part, the side wall of discharge chamber 53 and described time Closed tube road 51 is connected, and 531 inner wall of discharge chamber is equipped with spiral helicine track, so that wind is after entering in discharge chamber 531 Whirlpool can be formed.

Embodiment 2

A kind of medical treatment art for coating, comprises the following steps：（1）Manufacture bag paddle：By talcum powder, hydroxypropyl methyl cellulose, nanometer Grade silicon dioxide is mixed to prepare bag paddle in mixer, wherein the talcum powder, hydroxypropyl methyl cellulose, nanoscale titanium dioxide Ratio of weight and number between silicon is 4：2.5:1.6；Specially take 40kg talcum powder, the hydroxypropyl methyl cellulose of 25kg, 1.6kg Nanometer grade silica be mixed to get；（2）Preheat tablet：Tablet to be coated is placed in coating equipment in sugar production line, such as Fig. 1-7 institutes Show, the coating equipment in sugar production line includes operating room 1, spray gun 4, air jet system 2, feed arrangement 3 and retracting device 5；The spray gun 4 is arranged on 1 bottom of operating room, the air jet system 2 include being sheathed on the sleeve 21 outside spray gun, the jet channel in sleeve and jet The jet member 23 and air blower 24 that passage is connected, are arranged on a heating member 25, the heating member 25 between the air blower 24 and sleeve 21 It is connected respectively by hose with air blower 24 and sleeve 21, the heating member is the heater directly bought on the market；The spray Part 23 is penetrated to be obliquely installed；1 bottom of operating room is equipped with blocking cylinder 11,11 lower part of blocking cylinder and 1 bottom wall of operating room Between be equipped with charging gap；During coating, hot gas is sprayed into coating equipment in sugar production line by the air jet system arranged on coating equipment in sugar production line bottom, it is right Heat up inside coating equipment in sugar production line；Specifically, the gas temperature of the air jet system injection is 58 DEG C, jet velocity 2L/h, So that the constant temperature in coating equipment in sugar production line maintains 55 DEG C, tablet is heated；（3）Coating：Coating equipment in sugar production line bottom is equipped with spray Rifle, bag paddle is sent in spray gun and by spray gun spray upwards by feeding part；Meanwhile the upward jet of air jet system so that Tablet has been sprayed and freely falling body, and the coating realized to tablet is contacted with bag paddle.

The other structures of the coating equipment in sugar production line are identical with the coating equipment in sugar production line structure in the embodiment 1, and so it will not be repeated.

Embodiment 3

A kind of medical treatment art for coating, comprises the following steps：（1）Manufacture bag paddle：By talcum powder, hydroxypropyl methyl cellulose, nanometer Grade silicon dioxide is mixed to prepare bag paddle in mixer, wherein the talcum powder, hydroxypropyl methyl cellulose, nanoscale titanium dioxide Ratio of weight and number between silicon is 3：1.1:0.96；Specially take 30kg talcum powder, the hydroxypropyl methyl cellulose of 11kg, The nanometer grade silica of 9.6kg is mixed to get；（2）Preheat tablet：Tablet to be coated is placed in coating equipment in sugar production line, as Fig. 1- Shown in 7, the coating equipment in sugar production line includes operating room 1, spray gun 4, air jet system 2, feed arrangement 3 and retracting device 5；The spray gun 4 Arranged on 1 bottom of operating room, the air jet system 2 include be sheathed on the sleeve 21 outside spray gun, the jet channel in sleeve, with The jet member 23 and air blower 24 that jet channel is connected, are arranged on a heating member 25, the heating between the air blower 24 and sleeve 21 Part 25 is connected by hose with air blower 24 and sleeve 21 respectively, and the heating member is the heater directly bought on the market；Institute Jet member 23 is stated to be obliquely installed；1 bottom of operating room is equipped with blocking cylinder 11,11 lower part of blocking cylinder and the operating room 1 Charging gap is equipped between bottom wall；During coating, heat is sprayed into coating equipment in sugar production line by the air jet system arranged on coating equipment in sugar production line bottom Gas, heats up coating equipment in sugar production line inside；Specifically, the gas temperature of the air jet system injection is 55 DEG C, jet velocity is 1.5L/h so that the constant temperature in coating equipment in sugar production line maintains 53 DEG C, is heated to tablet；（3）Coating：Coating equipment in sugar production line bottom Equipped with spray gun, bag paddle is sent in spray gun and by spray gun by feeding part and is sprayed upwards；Meanwhile air jet system sprays upwards Gas so that tablet has been sprayed and freely falling body, and the coating realized to tablet is contacted with bag paddle.

Obviously, described embodiment is only the part of the embodiment of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work Embodiment, should all belong to the scope of protection of the invention.

Claims

A kind of 1. medical treatment art for coating, it is characterised in that：Comprise the following steps：

Manufacture bag paddle：Talcum powder, hydroxypropyl methyl cellulose, nanometer grade silica are mixed to prepare bag paddle；

Preheat tablet：Tablet is placed in coating equipment in sugar production line, by the air jet system arranged on coating equipment in sugar production line bottom into coating equipment in sugar production line Hot gas is sprayed into, is heated up to coating equipment in sugar production line inside to heat tablet；

Coating：Coating equipment in sugar production line bottom is equipped with spray gun, is sent bag paddle in spray gun and by spray gun by feeding part and sprayed upwards； Meanwhile the upward jet of air jet system so that tablet has been sprayed and freely falling body, and the coating realized to tablet is contacted with bag paddle.
A kind of 2. medical art for coating according to claim 1, it is characterised in that：The talcum powder, hydroxypropyl methyl are fine Ratio of weight and number between dimension element, nanometer grade silica is 2-4：1.5-2.5:1.3-1.6.
A kind of 3. medical art for coating according to claim 2, it is characterised in that：The talcum powder, hydroxypropyl methyl are fine Ratio of weight and number between dimension element, nanometer grade silica is 3：1.1:0.96.
A kind of 4. medical art for coating according to claim 2, it is characterised in that：In preheating step, the coating is set Standby interior temperature maintains 50-55 DEG C；The gas temperature of the air jet system injection is 55-58 DEG C, jet velocity 1-2L/h.
A kind of 5. medical art for coating according to claim 1, it is characterised in that：The coating equipment in sugar production line includes operating room （1）, spray gun（4）, air jet system（2）, feed arrangement（3）And retracting device（5）；The spray gun（4）Arranged on operating room（1）Bottom Portion, the air jet system（2）Including the sleeve being sheathed on outside spray gun（21）, jet channel and and jet channel in sleeve Connected jet member（23）.
A kind of 6. medical art for coating according to claim 5, it is characterised in that：The spray gun（4）Including gun barrel and mist Change nozzle, the atomizer includes head body（41）, feeding-passage（42）, the first atomization chamber arranged on head body top （43）And it is symmetrically set in the second atomization chamber of head body sidepiece（44）With the 3rd atomization chamber（45）；First atomization chamber （43）, the second atomization chamber（44）And the 3rd atomization chamber（45）Pass through a spray main channel respectively（46）With the feeding-passage（42） It is connected.
A kind of 7. medical art for coating according to claim 6, it is characterised in that：First atomization chamber（43）, second Atomization chamber（44）And the 3rd atomization chamber（45）Inside it is respectively equipped with primary atomization component（47）With secondary atomization component（48）, it is described first Level atomization component（47）With secondary atomization component（48）Between have spacing supply medium injection and scattered atomizing space to be formed Between.