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CN107970333A - A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof - Google Patents

A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof Download PDF

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Publication number
CN107970333A
CN107970333A CN201610915736.0A CN201610915736A CN107970333A CN 107970333 A CN107970333 A CN 107970333A CN 201610915736 A CN201610915736 A CN 201610915736A CN 107970333 A CN107970333 A CN 107970333A
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chinese medicine
traditional chinese
oral liquid
respiratory tract
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钟伟权
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

The present invention provides a kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof, the traditional Chinese medicine oral liquid is made of honeysuckle, dandelion, radix scutellariae, pinellia, blackberry lily, subprostrate sophora, Radix Isatidis and Fructus Forsythiae, 13 parts of honeysuckle, 24 parts of dandelion based on its parts by weight, 13 parts of radix scutellariae, 13 parts of pinellia, 12 parts of blackberry lily, 24 parts of subprostrate sophora, 13 parts of Radix Isatidis, 12 parts of Fructus Forsythiae, which is made by boiling extraction;The traditional Chinese medicine oral liquid of the treatment fowl bacterial respiratory tract disease, by traditional Chinese medicine reasonable formula, clearing heat and detoxicating, relieving sore-throat of subsiding a swelling, qi-regulating and it is middle the effect of it is notable.

Description

A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof
Technical field
The present invention relates to a kind of traditional Chinese medicine oral liquid and preparation method thereof, especially one kind to treat fowl bacterial respiratory tract disease disease Traditional Chinese medicine oral liquid and preparation method thereof.
Background technology
With the fast development of aquaculture, disease also develops therewith, particularly respiratory disease, and morbidity is more and more, Treat more and more difficult.The abuse of chemicals has had resulted in serious bacterial drug resistance and environmental pollution.China's Chinese medicine money Source is enriched, and by carrying out rationally screening and prescription, and reform preparation process to traditional Chinese medicine, is prepared as treatment fowl The choice drug of bacterial respiratory tract disease, will have very important production practices meaning.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease.
Another technical problem to be solved by this invention is the traditional Chinese medicine mouth for providing above-mentioned treatment fowl bacterial respiratory tract disease Take the preparation method of liquid.
In order to solve the above technical problems, the technical scheme is that:
A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease, by honeysuckle, dandelion, radix scutellariae, pinellia, blackberry lily, mountain Beans root, Radix Isatidis and Fructus Forsythiae composition, honeysuckle 1-3 parts based on its parts by weight, 2-4 parts of dandelion, 1-3 parts of radix scutellariae, pinellia 1-3 parts, 1-2 parts of blackberry lily, 2-4 parts of subprostrate sophora, 1-3 parts of Radix Isatidis, 1-2 parts of Fructus Forsythiae.
Preferably, the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, is obtained by following methods:
(1)Weigh 1-3 parts of honeysuckle, 2-4 parts of dandelion in parts by weight, 1-3 parts of radix scutellariae, 1-3 parts of pinellia, 1-2 parts of blackberry lily, 2-4 parts of subprostrate sophora, 1-3 parts of Radix Isatidis, 1-2 parts of Fructus Forsythiae are raw material;
(2)Subprostrate sophora is shredded, vinegar is carried out and carries, vinegar:Water=6:4.
(3) by remaining 7 taste Chinese medicine chopping mixing after, soak, water be cooked by slow fire after opening 1-2 it is small when, filtering, again to Add water in medicinal material and decoct twice, 30-60 minutes each, filtering;
(4)Merging filtrate, filtrate is concentrated, alcohol precipitation, adds water polishing, filtration, filtrate sterilizing, to obtain the final product.
Preferably, the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, the honeysuckle 1-3 based on its parts by weight Part, 2-3 parts of dandelion, 1-2 parts of radix scutellariae, 1-2 parts of pinellia, 1-2 parts of blackberry lily, 2-4 parts of subprostrate sophora, 1-3 parts of Radix Isatidis, Fructus Forsythiae 1- 2 parts.
Preferably, the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, based on its parts by weight 3 parts of honeysuckle, 2 parts of dandelion, 2 parts of radix scutellariae, 1 part of pinellia, 2 parts of blackberry lily, 4 parts of subprostrate sophora, 2 parts of Radix Isatidis, 2 parts of Fructus Forsythiae.
The preparation method of the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, specific preparation process are as follows:
(1)Weigh 3 parts of honeysuckle, 2 parts of dandelion in parts by weight, 2 parts of radix scutellariae, 1 part of pinellia, 2 parts of blackberry lily, 4 parts of subprostrate sophora, 2 parts of Radix Isatidis, 2 parts of Fructus Forsythiae are raw material;
(2)Subprostrate sophora is shredded, vinegar is carried out and carries, vinegar:Water=6:4.
(3) by remaining 7 taste Chinese medicine chopping mixing after, soak, water be cooked by slow fire after opening 1-2 it is small when, filtering, again to Add water in medicinal material and decoct twice, 30-60 minutes each, filtering;
(4)Merging filtrate, filtrate is concentrated, alcohol precipitation, adds water polishing, filtration, filtrate sterilizing, to obtain the final product.
Preferably, the preparation method of the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, the step(2)It is middle to incite somebody to action Subprostrate sophora shreds, and carries out vinegar and carries, vinegar:Water=6:4.
The beneficial effects of the invention are as follows:
The traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, by traditional Chinese medicine reasonable formula, clearing heat and detoxicating, detumescence profit Pharynx, qi-regulating and it is middle the effect of it is notable, provide a kind of effective medicine of fowl bacterial respiratory tract disease for poultry husbandry, with take With convenient, quick, curative effect really, no drug residue, the characteristics of being not likely to produce drug resistance, is without any side effects;Its preparation method Simply, it is adapted to the needs of scale industrial production.
Embodiment
Technical solution of the present invention is further described with reference to specific embodiment.
Embodiment 1
A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease, by honeysuckle, dandelion, radix scutellariae, pinellia, blackberry lily, mountain Beans root, Radix Isatidis and Fructus Forsythiae composition, wherein, honeysuckle 300g, dandelion 200g, radix scutellariae 200g, pinellia 100g, blackberry lily 200g, subprostrate sophora 400g, Radix Isatidis 200g, Fructus Forsythiae 200g.
The preparation method of the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, specific preparation process are as follows:
(1)Honeysuckle 300g, dandelion 200g, radix scutellariae 200g, pinellia 100g, blackberry lily 200g, mountain beans are weighed in parts by weight Root 400g, Radix Isatidis 200g, Fructus Forsythiae 200g are raw material;
(2)Subprostrate sophora is shredded, vinegar is carried out and carries, vinegar:Water=6:4.
(3) by remaining 7 taste Chinese medicine chopping mixing after, soak, water be cooked by slow fire after opening 1-2 it is small when, filtering, again to Add water in medicinal material and decoct twice, 30-60 minutes each, filtering;
(4)Merging filtrate, filtrate is concentrated, alcohol precipitation, adds water polishing to 1000ml, filtration, filtrate to sterilize, to obtain the final product.
Embodiment 2
A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease, by honeysuckle, dandelion, radix scutellariae, pinellia, blackberry lily, mountain Beans root, Radix Isatidis and Fructus Forsythiae composition, wherein, honeysuckle 200g, dandelion 300g, radix scutellariae 200g, pinellia 200g, blackberry lily 100g, subprostrate sophora 300g, Radix Isatidis 200g, Fructus Forsythiae 200g.
The preparation method of the traditional Chinese medicine oral liquid of above-mentioned treatment fowl bacterial respiratory tract disease, specific preparation process are as follows:
(1)Honeysuckle 200g, dandelion 300g, radix scutellariae 200g, pinellia 200g, blackberry lily 100g, mountain beans are weighed in parts by weight Root 300g, Radix Isatidis 200g, Fructus Forsythiae 200g are raw material;
(2)Subprostrate sophora is shredded, vinegar is carried out and carries, vinegar:Water=6:4.
(3) by remaining 7 taste Chinese medicine chopping mixing after, soak, water be cooked by slow fire after opening 1-2 it is small when, filtering, again to Add water in medicinal material and decoct twice, 30-60 minutes each, filtering;
(4)Merging filtrate, filtrate is concentrated, alcohol precipitation, adds water polishing to 1000ml, filtration, filtrate to sterilize, to obtain the final product.
Chinese medicine described in embodiment is commercial product, is met《Chinese veterinary pharmacopoeia》Two ministerial standard of version in 2010.Will be each Amounts of components is increased or decreased according to same ratio, and the parts by weight relation of gained each component belongs to the protection model of the present invention Enclose.
8 taste Chinese medicines share in prescription, mutually synergistic, play altogether clearing heat and detoxicating, detumescence relieving sore-throat, qi-regulating and it is middle the effect of, Available for the prevention that cough is warmed caused by many reasons, especially with proportioning described in embodiment 1, particularly suitable fowl is bacillary to be exhaled Inhale the prevention of road disease.
Clinical test example:
The effect of artificial challenge fowl bacterial respiratory tract disease disease, tests
120 60 ages in days are randomly divided into 3 groups, every group 40 according to the brown commercial generation Adult cockerel of Sha.Except the sterilizing of healthy chicken control group is given birth to Manage brine collunarium, the equal collunarium ehec infection of every chicken of remaining each group, 36 it is small when after test chicken(Except healthy control group)Go out Existing typical case's respiratory symptom, drug test group are launched the medicine of corresponding dosage in drinking-water, 2 times/day, are used in conjunction 5 days respectively.
After administration group of the present invention administration, diseased chicken respiratory symptom substantially mitigates, and the death rate drops to 10%, not administration group The death rate reaches more than 80%.Illustrate that traditional Chinese medicine oral liquid treatment fowl bacterial respiratory tract disease of the present invention obtains good result, have Efficiency is up to more than 90%.
It is above-mentioned with reference to embodiment to a kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease and preparation method thereof into Capable detailed description, is illustrative rather than limited, can include several embodiments according to limited scope, therefore Changing and modifications in the case where not departing from present general inventive concept, should belong within protection scope of the present invention.

Claims (4)

  1. A kind of 1. traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease, it is characterised in that:By honeysuckle, dandelion, radix scutellariae, Pinellia, blackberry lily, subprostrate sophora, Radix Isatidis and Fructus Forsythiae composition, honeysuckle 1-3 parts based on its parts by weight, 2-4 parts of dandelion are yellow 1-3 parts of a kind of reed mentioned in ancient books, 1-3 parts of pinellia, 1-2 parts of blackberry lily, 2-4 parts of subprostrate sophora, 1-3 parts of Radix Isatidis, 1-2 parts of Fructus Forsythiae.
  2. 2. the traditional Chinese medicine oral liquid for the treatment of fowl bacterial respiratory tract disease disease according to claim 1, it is characterised in that:It is under What the method for stating obtained:
    (1)Weigh 1-3 parts of honeysuckle, 2-4 parts of dandelion in parts by weight, 1-3 parts of radix scutellariae, 1-3 parts of pinellia, 1-2 parts of blackberry lily, 2-4 parts of subprostrate sophora, 1-3 parts of Radix Isatidis, 1-2 parts of Fructus Forsythiae are raw material;
    (2)Subprostrate sophora is shredded, vinegar is carried out and carries, vinegar:Water=6:4.
    (3) by remaining 7 taste Chinese medicine chopping mixing after, soak, water be cooked by slow fire after opening 1-2 it is small when, filtering, again to medicinal material In plus water and decoct twice, it is 30-60 minute each, filter;
    (4)Merging filtrate, filtrate is concentrated, alcohol precipitation, adds water polishing, filtration, filtrate sterilizing, to obtain the final product.
  3. 3. the traditional Chinese medicine oral liquid for the treatment of fowl bacterial respiratory tract disease disease according to claim 1 or 2, it is characterised in that:Press Its 1-3 parts of parts by weight meter honeysuckle, 3-4 parts of dandelion, 1-2 parts of radix scutellariae, 1-3 parts of pinellia, 1-2 parts of blackberry lily, subprostrate sophora 3-4 Part, 1-3 parts of Radix Isatidis, 1-2 parts of Fructus Forsythiae.
  4. 4. the traditional Chinese medicine oral liquid for the treatment of fowl bacterial respiratory tract disease disease according to claim 3, it is characterised in that:It is heavy by its Measure 3 parts of number meter honeysuckle, 3 parts of dandelion, 2 parts of radix scutellariae, 2 parts of pinellia, 1 part of blackberry lily, 3 parts of subprostrate sophora, 1 part of Radix Isatidis, company Stick up 2 parts.
CN201610915736.0A 2016-10-21 2016-10-21 A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof Pending CN107970333A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2450046A1 (en) * 2009-06-30 2012-05-09 Hebei Yiling Medicine Research Institute Co., Ltd. A medicinal composition for the treatment of bronchitis and preparation thereof
CN103463346A (en) * 2013-09-23 2013-12-25 大连金鹏畜牧专业合作社 Medicine for treating chicken respiratory disease and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2450046A1 (en) * 2009-06-30 2012-05-09 Hebei Yiling Medicine Research Institute Co., Ltd. A medicinal composition for the treatment of bronchitis and preparation thereof
CN103463346A (en) * 2013-09-23 2013-12-25 大连金鹏畜牧专业合作社 Medicine for treating chicken respiratory disease and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李炳奇: "《有机化学》", 31 December 2010 *
胡小勤: "《中药学》", 31 December 2013, 西安交通大学出版社 *

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Application publication date: 20180501