CN107961356A - Keep a public place clean for anus, clearly, maintenance, the external nursing product of Mucous rehabilitation - Google Patents
Keep a public place clean for anus, clearly, maintenance, the external nursing product of Mucous rehabilitation Download PDFInfo
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- CN107961356A CN107961356A CN201810064203.5A CN201810064203A CN107961356A CN 107961356 A CN107961356 A CN 107961356A CN 201810064203 A CN201810064203 A CN 201810064203A CN 107961356 A CN107961356 A CN 107961356A
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- anus
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- propolis
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
It is a kind of keep a public place clean for anus, clearly, maintenance, the external nursing product of Mucous rehabilitation, it with propolis supercritical extract, Rhizoma Curcumae extract, fiery sesame oil, Asian puccoon, purple perilla bank up the roots of seedlings oil etc. for component drug raw material, with CO2After supercritical technology carries out separating and extracting, low-temperature centrifugation, then care article is made after membrane separation.Inventive formulation and production method are unique, integrates validity and security, can protect the clean environment of anus area, to keeping a public place clean inside and outside anus, antibacterial, it is salubrious, moisten anus and repair anal mucosa membrane and damage etc. and have the function that good, using effect is notable.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and relates to an external care product which is prepared from natural Chinese herbal medicines as raw materials and is used for anus cleaning, refreshing, maintenance and mucous membrane repair, and a preparation method of the external care product.
Background
Anal diseases are common diseases and frequently encountered diseases which are specific to human beings, and the anal diseases are various in types and mainly comprise: hemorrhoid, anal fissure, anal fistula, perianal abscess, rectocele, pruritus ani, tenesmus, polyp in anus, cyst, constipation, etc. In China, hemorrhoids are the most common anal diseases for a long time, and the expressions of 'nine hemorrhoids for ten men' and 'ten hemorrhoids for ten women' are used as the essentials. With the rapid development of new normal economy in China in the last decade, the medical level of the whole society is greatly improved. However, the problems of anal diseases are not completely solved, but rather, the problems are frequently encountered and cause health problems. In summary, the symptoms are caused by the physiological disorders such as poor dietary life habits, poor sanitation, lack of exercise, poor defecation habits, chronic diarrhea, chronic dysentery, long-term constipation and the like of the Chinese, and are actually the phenomena of mucosa injury caused by mucosal histiocyte metabolic disorders inside and outside the anus and intestines or 'pimple' caused by water metabolic disorders. The anus is the largest outlet for human waste excretion, and cleaning, lubricating and maintaining the anus are effective methods for eliminating anus infection and maintaining the stretching force of the anal sphincter, otherwise the anus is the first major factor harming the health of the anus and the intestine.
Hemorrhoid, hematochezia, rectocele, polyp, cyst and anal fissure are all diseases of anus mucosa tissue cell injury in anus caused by infection of exogenous virus, bacteria and other factors, and simultaneously are diseases of anus mucosa tissue injury caused by anus tissue withering or swelling caused by anus tissue cell dysfunction, anus system water system metabolism, blood system metabolic disorder and other comprehensive factors. Because the epidermal histiocyte in the anus and rectum passages is a cell with secretion capacity, and has the functions of secreting self-cleaning substances, secreting lubricating liquid and secreting membrane liquid (blocking the communication between the outside and the anus), when the diseases are treated, the used medicines have certain irritation, the damage to the secretion function of the mucous membrane cells in the anus and intestine passages is caused, or the secretion capacity of the mucous membrane cells in the anus and intestine is attenuated by adopting methods such as mechanical operation and the like, so that the anus is prematurely dry and astringent, the secretion function of vaginal cells is reduced, and the phenomena of anal fissure and anal dry constipation are caused.
At present, the medicines for treating the anal diseases at home and abroad mainly comprise chemical medicines, paste, suppositories, gels, oral medicines and injections. Wherein,
① the chemical has antiinflammatory and antibacterial effects, but has obvious irritation side effect on cells of mucous membrane inside and outside anus system;
② the ointment, gel, and suppository have high impurity content, and the impurity has high inhibition effect on the secretion of cells of the inner membrane of anus;
③ the oral preparation and injection have effects of eliminating inflammation, but the medicine can not reach the symptom part directly to achieve direct effect;
in addition, the operation method for treating the anus disease at home and abroad can not solve the problem of repeated infection of the anus, but can cause permanent damage to mucosal tissue cells inside and outside the anus, thereby influencing the functional quality of the anus. However, the currently marketed drugs or nursing products for anal diseases have various effects of diminishing inflammation, resisting bacteria and the like, but none of the drugs or nursing products has the problem of reducing irritation to cells of the anal inner mucosa and the problem of maintaining the self-secretion capability of cells of the anal inner mucosa tissue, and the used drugs or nursing products still have impurities which cannot be absorbed or metabolized in the anal intestinal tract, so that the secretion capability of the anal inner mucosa is attenuated. In summary, in the technical field, the development of a biological product capable of effectively protecting the clean environment of the anorectal tract and promoting the increase of the secretion of mucosal cells in the anorectal tract to reduce the use frequency of the medicine at the anus part is expected to be an anal medicine in future and is an important index for delaying the aging of the function of the mucosal cells in the anorectal tract.
Disclosure of Invention
The invention aims to solve the problems in the prior art, and further provides an external care product which is prepared from natural Chinese herbal medicines and is used for anus cleaning, refreshing, maintenance and mucosa repair.
The preparation scheme of the external care product is obtained by the designer through careful summarization and development according to the traditional Chinese medicine diagnosis and treatment thought and the modern medicine experiment basis, and the external care product is a pure natural traditional Chinese medicine care product prepared by adopting the modern biological preparation technical means on the basis of pharmacological analysis data of selected natural biological materials and practical experience and knowledge on anus diseases and anorectal tract cleaning effect. The effective medicinal components of the external care product are prepared from the following raw materials in parts by weight:
the method for preparing the external care product comprises the following process steps:
1. preparing a propolis supercritical extract: charging CO into propolis2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction on the liquid at the extraction temperature of 15-30 ℃, the extraction pressure of 8-10 MPa and the extraction time of 1-2 hours to obtain a yellow propolis extract containing plant flavonoid components, wherein the percentage content of the supercritical extraction is 1-2%;
2. preparing a curcuma zedoary extract: directly charging Curcumae rhizoma seed into CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction on the liquid at the extraction temperature of 20-30 ℃ under the extraction pressure of 2-7 MPa for 1-2 hours to obtain a zedoary turmeric extract containing plant curcumenone components;
3. preparing the hemp oil: loading fructus Cannabis into squeezer, squeezing at room temperature, and leaching to obtain fructus Cannabis oil containing oil components of linoleic acid (-6) and alpha-linolenic acid;
4. preparing purple perilla seed oil: putting the perilla seeds into a squeezer, squeezing at normal temperature, and leaching to obtain perilla seed oil containing an alpha-linolenic acid component;
5. preparing a lithospermum extract: mechanically crushing lithospermum, immersing into a part of purple perilla seed oil, keeping the temperature at 45-60 ℃ for 1-2 hours, and centrifuging at low temperature to obtain lithospermum immersion liquid containing alkannin components, wherein the mass ratio of lithospermum to purple perilla seed oil is 1: 20;
6. dissolving the propolis supercritical extract, the curcuma zedoary extract, the cannabis oil and the lithospermum extract in perilla seed oil according to the formula composition requirements, mixing, freezing and centrifuging to remove sediments under the following process conditions, wherein the freezing temperature is 0-4 ℃, the centrifugal speed is 3000-4000 rpm, the time is 10-20 minutes, the centrifugate is separated by a sound film separator to obtain liquid medicine with the molecular weight less than 10000D, and then bottling or bagging the liquid medicine to obtain the product.
The external care product prepared from the medicinal raw materials fully embodies the syndrome differentiation and treatment principle of 'origin-correcting and source-clearing' and 'treatment of symptoms and shoulders' in the traditional Chinese medicine, and the pharmacological effects of the components in the formula are as follows:
the pharmacological action of propolis: the propolis extract is prepared by using CO2The propolis substance obtained by supercritical extraction process contains natural plant flavonoids as main ingredient, and the propolis flavonoids are natural broad-spectrum antibacterial agent and antioxidant; the propolis can obviously enhance the cellular immune function and the organism immune function, has stronger bactericidal power and bacteriostatic power, plays an effective role in resisting bacteria and diminishing inflammation, and enhances the disease resistance and the self-healing power of a human body; the oxidation resistance of the propolis can effectively stabilize and eliminate free radicals, protect cell membranes, enhance cell activity and promote the self-secretion function of cells, and the propolis is a honeycomb cleaning agent, maintains the cleanness of the honeycomb and also has a clean biological effect on the anorectal system of a human body.
Pharmacological action of zedoary: has effects in promoting qi and blood circulations, removing food stagnation, relieving pain, removing blood stasis, removing necrotic tissue, promoting granulation, enhancing immunity, killing bacteria, promoting wound healing, treating RSV infected cells, and inhibiting virus reproduction.
The pharmacological action of the cannabis oil is as follows: sweet taste and mild nature, can moisten dryness and smooth intestines, nourish and tonify deficiency; the oleum Cannabis contains linolenic acid and linoleic acid, and has effects of regulating capillary blood vessel penetration, improving blood circulation, loosening bowel to relieve constipation, and can be used for treating constipation due to blood deficiency and body fluid deficiency.
The pharmacological action of the lithospermum: resolving putridity and promoting granulation, and can be used for treating pyocutaneous disease, carbuncle, cellulitis and ulceration; cool blood, activate blood, remove toxicity and promote eruption. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water and fire.
The perilla seed oil has pharmacological action of using as solvent in a prescription, contains α -linolenic acid as main ingredient with content of 50-70%, and has antithrombotic, antiallergic, antiinflammatory and antiaging effects.
Clinical use results show that the external care product has the following advantages:
the nursing product is prepared from natural materials according to the technical requirements of biological products, and has the important characteristics that the product contains propolis plant flavone, zedoary turmeric ketone, saffron crocus and alpha-linolenic acid, does not contain synthetic drugs and anaphylactic substances, is nontoxic, harmless and nonirritant to human bodies, does not have any side effect, can prevent repeated infection of anus, and cleans the environment inside and outside the anus; the second important characteristic is that the product does not have irritation to the cells of the inner mucous membrane of the anus and does not have toxic and side effects on the metabolism of the cells of the inner and outer tissues of the anus; the third characteristic is that the effective components contained in the nursing product are low molecular weight and are easy to be absorbed by the skin of the anus.
Secondly, the product of the invention is used as an anus maintenance cleaning product and has the functions of refreshing anus, moistening anus and intestine, relieving and eliminating constipation.
The product of the invention is used as an anal system nursing product, and has the functions of repairing the mucous membrane injury in the anus and the intestine and relieving and eliminating the physical therapy functions of anorectal polyps, cysts, hematochezia and anal fissure.
Fourthly, the product of the invention has better physical therapy and nursing effects on the recovery of anus diseases.
Fifthly, the product of the invention has obvious improvement effect on pruritus ani, senile constipation caused by dryness of anus, feeling of falling and swelling and prolapse of anus which appear in middle-aged and elderly people.
In specific implementation, the medicament can be prepared into various external care products for cleaning, refreshing and maintaining anus and repairing mucous membrane, such as anus soft capsules, anus external hemorrhoid smearing oil and the like. The preparation process of the soft anus capsule comprises the steps of taking the external care product and ossein as raw materials of a soft capsule shell preparation, and preparing the soft capsule according to the soft capsule process steps. The preparation method of the anus external hemorrhoid liniment comprises packaging the external care product directly into a container to obtain oily liniment.
The product has the effects of preventing anus infection, inhibiting bacteria, resisting bacteria and viruses, cleaning anus, refreshing liver, moistening anus, eliminating pruritus ani and repairing polyp, cyst, hematochezia, anal fissure and anal prolapse caused by the injury of mucous membrane cells in the anus and intestine. The product of the invention is proved by practical research to have good effects on cleaning, maintaining and physical therapy of anus and eliminating constipation, pruritus, feeling of falling and swelling and prolapse of anus caused by dysfunction of anus by product research of nearly ten years and repeated clinical trials. The effectiveness of the product of the invention is based on the standard of anus function cleaning degree, anus refreshing degree, anus moistening and constipation eliminating degree, anus pruritus eliminating degree and nourishing comfort degree, the obvious effectiveness is based on the standard of no anoectogenesis (hematochezia, anus prolapse, anal fissure, cyst and polyp) of anus and anus intestine, the preventive performance is based on the standard of normal anus symptoms, and the statistical visit is carried out on patients treated in the last decade as follows:
the statistical data is 350 persons, the effective rate is 100%, and the significant efficiency is 78%.
The anus soft capsule is used for cleaning anus, refreshing anus, eliminating pruritus ani, moistening anus and eliminating constipation in 2008 to 2014 12 months, the statistics of the curative effects of 350 people are carried out, the days for observing the treatment course are 15-45 days, wherein the 350 people are all effective, and the effective rate reaches 100%; the anus soft capsule products (specification: 0.5 ml/capsule) are used by 60-90 capsules for the people with hematochezia, anal prolapse, anal fissure, anal fistula, cyst and polyp on average, 2 capsules are used every day, wherein one capsule is smeared on the anus and the other capsule is placed in the anus; after use, 275 persons have no abnormality inside and outside the anus, and the obvious effect reaches over 78.5 percent.
Detailed Description
Example one
The raw materials of the medicinal components of the external care product are prepared by the following method:
supercritical extraction of propolis: charging CO into propolis2Supercritical extraction tank, adding CO circularly2And (3) carrying out supercritical extraction on the liquid at the extraction temperature of 25 ℃ and the extraction pressure of 10MPa for 1 hour to obtain 1-1.5% of a yellow and bright natural propolis supercritical extract which does not contain heavy metals and contains plant flavonoid components.
And (3) extracting the curcuma zedoary: directly charging Curcumae rhizoma seed into CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction of the liquid at 25 deg.C under 5MPa for 1.5 hr to obtain zedoary turmeric seed oil extract containing plant curcumenone components.
Hemp oil: loading fructus Cannabis into squeezer, squeezing at room temperature, and leaching to obtain fructus Cannabis oil containing oil components of linoleic acid (-6) and alpha-linolenic acid.
Purple perilla seed oil: loading fructus Perillae into a squeezer, squeezing at room temperature, and leaching to obtain fructus Perillae oil containing alpha-linolenic acid.
Soaking radix arnebiae in liquid: mechanically crushing 100g radix Arnebiae, soaking in 2000g of above perilla seed oil, maintaining at 50 deg.C for 2 hr, and centrifuging at low temperature to obtain transparent oily red gem-red radix Arnebiae extractive solution containing alkannin.
(II) preparing raw materials according to the following proportion:
(III) the production method comprises the following steps:
1. dissolving the propolis extract, the zedoary turmeric oil, the hemp seed oil and the lithospermum extract into the rest 18kg of perilla seed oil respectively according to the adding amount, removing sediments through freezing and centrifuging under the following process conditions, wherein the freezing temperature is 0-4 ℃, the centrifugal speed is 3000-4000 rpm, the time is 20 minutes, and the centrifugate is separated through an acoustic membrane separator to obtain liquid medicine with the molecular weight less than 10000D.
2. And (4) subpackaging the separated liquid into soft capsules or subpackaging into bottles to obtain finished products.
The formula has high obvious effect on hematochezia, rectocele, anal fissure and polyp in the anus.
Example two
The raw materials of the medicinal components of the external care product are prepared by the following method:
supercritical extraction of propolis: charging CO into propolis2Supercritical extraction tank, adding CO circularly2And (3) carrying out supercritical extraction on the liquid at the extraction temperature of 30 ℃, under the extraction pressure of 8MPa, and for 1.5 hours to obtain 1-2% of a yellow and bright natural propolis supercritical extract which does not contain heavy metals and contains plant flavonoid components.
And (3) extracting the curcuma zedoary: directly charging Curcumae rhizoma seed into CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction of the liquid at 30 deg.C under 5MPa for 2 hr to obtain zedoary turmeric seed oil extract containing curcumenone.
Hemp oil: loading fructus Cannabis into squeezer, squeezing at room temperature, and leaching to obtain fructus Cannabis oil containing oil components of linoleic acid (-6) and alpha-linolenic acid.
Purple perilla seed oil: loading fructus Perillae into a squeezer, squeezing at room temperature, and leaching to obtain fructus Perillae oil containing alpha-linolenic acid.
Soaking radix arnebiae in liquid: mechanically crushing 100g radix Arnebiae, soaking in 2000g of above perilla seed oil, maintaining at 50 deg.C for 2 hr, and centrifuging at low temperature to obtain transparent oily red gem-red radix Arnebiae extractive solution containing alkannin.
(II) preparing raw materials according to the following proportion:
(III) the production method comprises the following steps:
1. dissolving propolis extract, zedoary turmeric oil, oleum Sesami and radix Arnebiae extract in the balance of 18kg Perilla seed oil, centrifuging at low temperature, removing residue, and collecting supernatant to obtain the final product.
2. And (4) subpackaging the separated liquid into soft capsules or subpackaging into bottles to obtain finished products.
The formula has high obvious efficiency of cleaning anus, refreshing anus and eliminating pruritus ani.
EXAMPLE III
The raw materials of the medicinal components of the external care product are prepared by the following method:
supercritical extraction of propolis: charging CO into propolis2Supercritical extraction tank, adding CO circularly2And (3) carrying out supercritical extraction on the liquid at the extraction temperature of 20 ℃, under the extraction pressure of 8MPa, and for 2 hours to obtain 1-2% of yellow and bright natural propolis supercritical extract which does not contain heavy metals and contains plant flavonoid components.
And (3) extracting the curcuma zedoary: directly charging Curcumae rhizoma seed into CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction of the liquid at 30 deg.C under 5MPa for 2 hr to obtain zedoary turmeric seed oil extract containing curcumenone.
Hemp oil: loading fructus Cannabis into squeezer, squeezing at room temperature, and leaching to obtain fructus Cannabis oil containing oil components of linoleic acid (-6) and alpha-linolenic acid.
Purple perilla seed oil: loading fructus Perillae into a squeezer, squeezing at room temperature, and leaching to obtain fructus Perillae oil containing alpha-linolenic acid.
Soaking radix arnebiae in liquid: mechanically crushing 100g radix Arnebiae, soaking in 2000g of above perilla seed oil, maintaining at 50 deg.C for 2 hr, and centrifuging at low temperature to obtain transparent oily red gem-red radix Arnebiae extractive solution containing alkannin.
(II) preparing raw materials according to the following proportion:
(III) the production method comprises the following steps:
1. dissolving propolis extract, zedoary turmeric oil, oleum Sesami and radix Arnebiae extract in the balance of 18kg Perilla seed oil, centrifuging at low temperature, removing residue, and collecting supernatant to obtain the final product.
2. And (4) subpackaging the separated liquid into soft capsules or subpackaging into bottles to obtain finished products.
The formula has high obvious effect on moistening anus, eliminating constipation, anal fistula and cyst in anus and intestine.
Claims (2)
1. A nursing product for external use for anus cleaning, refreshing, maintenance and mucosa repair is characterized in that the effective pharmaceutical ingredients are prepared from the following raw materials in parts by weight:
the method for preparing the external care product comprises the following process steps:
1.1 preparation of propolis supercritical extract: loading propolis into the container CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction on the liquid at the extraction temperature of 15-30 ℃, the extraction pressure of 8-10 MPa and the extraction time of 1-2 hours to obtain a yellow propolis extract containing plant flavonoid components, wherein the percentage content of the supercritical extraction is 1-2%;
1.2 preparation of zedoary extract: directly charging Curcumae rhizoma seed into CO2Supercritical extraction tank, adding CO circularly2Performing supercritical extraction on the liquid at the extraction temperature of 20-30 ℃ under the extraction pressure of 2-7 MPa for 1-2 hours to obtain a zedoary turmeric extract containing plant curcumenone components;
1.3 preparation of hemp oil: putting fructus Cannabis into a squeezer, squeezing at normal temperature, and leaching to obtain oleum Sesami containing oil components of linoleic acid (-6) and alpha-linolenic acid;
1.4 preparation of purple perilla seed oil: putting the perilla seeds into a squeezer, squeezing at normal temperature, and leaching to obtain perilla seed oil containing an alpha-linolenic acid component;
1.5 preparation of the lithospermum infusion: mechanically crushing lithospermum, immersing into a part of purple perilla seed oil, keeping the temperature at 45-60 ℃ for 1-2 hours, and centrifuging at low temperature to obtain lithospermum immersion liquid containing alkannin components, wherein the mass ratio of lithospermum to purple perilla seed oil is 1: 20;
1.6 dissolving the propolis supercritical extract, the curcuma zedoary extract, the cannabis oil and the lithospermum extract in perilla seed oil according to the formula composition requirements, mixing, freezing and centrifuging to remove sediments under the following process conditions, wherein the freezing temperature is 0-4 ℃, the centrifugal speed is 3000-4000 rpm, and the time is 10-20 minutes, the centrifugate is separated by a sound film separator to obtain liquid medicine with the molecular weight less than 10000D, and then the liquid medicine is bottled or bagged to obtain the product.
2. An anus soft capsule prepared by the external care product of claim 1, which is characterized in that the anus soft capsule is prepared by the external care product and ossein serving as raw materials of a soft capsule shell preparation according to the soft capsule process steps.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
| CN104096163A (en) * | 2013-04-08 | 2014-10-15 | 韦建学 | External drug for maintenance and sanitation of ovary, inner labia and vulva of women |
| CN105748583A (en) * | 2014-12-19 | 2016-07-13 | 杨宝凤 | An encapsulated vagina cleaning liquid and a preparing process thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
| CN104096163A (en) * | 2013-04-08 | 2014-10-15 | 韦建学 | External drug for maintenance and sanitation of ovary, inner labia and vulva of women |
| CN105748583A (en) * | 2014-12-19 | 2016-07-13 | 杨宝凤 | An encapsulated vagina cleaning liquid and a preparing process thereof |
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Application publication date: 20180427 |