CN107961257A - A kind of preparation method for wearing yellow antipyretic capsule - Google Patents
A kind of preparation method for wearing yellow antipyretic capsule Download PDFInfo
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- CN107961257A CN107961257A CN201711257807.3A CN201711257807A CN107961257A CN 107961257 A CN107961257 A CN 107961257A CN 201711257807 A CN201711257807 A CN 201711257807A CN 107961257 A CN107961257 A CN 107961257A
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- herba andrographitis
- antipyretic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Natural Medicines & Medicinal Plants (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of preparation method for wearing yellow antipyretic capsule, the active ingredient of goldenrod, Herba Andrographitis is extracted to obtain thick paste with the technique being combined of alcohol precipitation processing by decocting, cellulase degradation extraction, and fermentation process is carried out to Herba Andrographitis fecula with probiotics saccharomyces cerevisiae, Bifidobacterium and obtains fermentation Herba Andrographitis powder, obtain wearing yellow antipyretic capsule after granulation, whole grain, filling capsule, packaging after fermentation Herba Andrographitis powder, cornstarch and thick paste are mixed evenly.The preparation method of the present invention improves the utilization rate of medicinal material active ingredient, and preparation wears yellow antipyretic capsule and can reduce toxicity and utilizations that be preferably absorbed by the body, improvement curative effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of preparation method for wearing yellow antipyretic capsule.
Background technology
Wearing yellow antipyretic capsule can be clearing heat and detoxicating, be one kind be mainly used for acute upper respiratory infection, acute tonsillitis,
The medicine of pharyngitis, its main component are Herba Andrographitis and goldenrod.Herba Andrographitis also known as Chun Lianqiuliu, Banlangen, Euphorbia, gall bladder
Grass, golden vanilla, golden tack, India's grass, eel grass etc., are annual herb plants, there is clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.
Goldenrod nature and flavor are pungent, bitter, tepor, can dispelling wind removing toxic substances, promoting circulation of blood of bringing down a fever, swelling and pain relieving.At present, the preparation side of yellow antipyretic capsule is worn
Method is mainly the crude drug powder and Herba Andrographitis, the extraction concentrated extract mixing granulation of goldenrod after Herba Andrographitis is crushed, and is then filled out
Capsule is filled to be made.This method is very low to the utilization rate of active ingredient in crude drug powder, and absorption of the human body to effective ingredient has
Limit, so as to limit the effect of wearing yellow antipyretic capsule.Therefore, it is necessary to existing preparation method is made improvements.
The content of the invention
A kind of the defects of the object of the invention is exactly to make up prior art, there is provided preparation method for wearing yellow antipyretic capsule.
The present invention is achieved by the following technical solutions：
A kind of preparation method for wearing yellow antipyretic capsule, comprises the following steps：
（1）180-200 parts by weight goldenrod, 80-100 parts by weight Herba Andrographitis are fitted into multi-function extractor, added suitable
2-4h is decocted in 10-15 times of water of medicinal material gross weight, filtering, add 2-2.5 percent by weight fiber into filter residue again after collecting filtrate
Plain enzyme and water of 8-10 times equivalent to medicinal material gross weight the enzymolysis processing 2-4h under the conditions of 40-50 DEG C, pH5-6,85-95 DEG C of enzyme deactivation
Filtered after 3-5min, collect filtrate, the filtrate obtained twice is merged, is concentrated under reduced pressure into clear cream；
（2）By step（1）Obtained clear cream is squeezed into Alcohol-settling tank, is added the ethanol stirring 0.5-1h of 90-95%, is then stood 48-
72h, thick paste is concentrated under reduced pressure into after filtering by filter vacuum；
（3）By 30-40 parts by weight Herba Andrographitis powder and 0.5-1 parts by weight saccharomyces cerevisiae, 0.1-0.15 parts by weight Bifidobacterium and
PH is adjusted to 3-4 after the mixing of 10-15 parts by weight water, ferment 24-48h in 35-45 DEG C, then in 60-80 DEG C of drying, is ground to
100-200 mesh, obtains fermentation Herba Andrographitis powder；
（4）By step（3）Obtained fermentation Herba Andrographitis powder and 1-1.5 parts by weight Corn starch is added in trough type mixing machine and stirred
10-15min, then adds step（2）Obtained thick paste is stirred for 10-15min, is pelletized and incited somebody to action with 14-16 mesh stainless steel mesh
The wet granular that makes is sent into heated-air circulation oven drying, then with 40-60 mesh stainless steel mesh whole grains, the dry particl after whole grain is added
Enter 0.6-0.8 parts by weight magnesium stearate mixing 0.5-1h, fill capsule, obtain wearing yellow antipyretic capsule after packaging.
The step（1）In the temperature that is concentrated under reduced pressure be 60-85 DEG C.
The step（1）The 1.14-1.16 when relative density of middle clear cream is 85 DEG C.
The step（2）The temperature of middle vacuum-concentrcted is 60-80 DEG C.
The step（2）1.31-1.35 when middle thick paste relative density is 60-80 DEG C.
The saccharomycete, the living bacteria count amount of lactic acid bacteria are hundred million CFU/g of 10-20.
The step（4）Middle drying temperature is 65-75 DEG C, drying time 3-4h.
It is an advantage of the invention that：
One aspect of the present invention by decocting, cellulase degradation extraction with alcohol precipitation handle the technique being combined to goldenrod,
The active ingredient of Herba Andrographitis is extracted to obtain extracting solution thick paste, according to containing a large amount of celluloses in goldenrod, Herba Andrographitis medicinal material,
The characteristics of hindering active ingredient to be fully dissolved out, is handled it using cellulase, so as to improve the extraction of active ingredient
Rate, improves active constituent content in thick paste；On the one hand using probiotics saccharomyces cerevisiae, Bifidobacterium to Herba Andrographitis fecula into
Row fermentation process, had not only reduced the toxicity of Herba Andrographitis crude drug powder, but also added the dissolution of active ingredient in crude drug powder, while beer
Saccharomycete and Bifidobacterium can also aid in absorption of the intestines and stomach to medicine, so as to play the effect of more preferable.The preparation side of the present invention
Method improves the utilization rate of medicinal material active ingredient, and preparation wears yellow antipyretic capsule and can reduce toxicity and preferably by human body
Absorb, improve curative effect.
Embodiment
A kind of preparation method for wearing yellow antipyretic capsule, comprises the following steps：
（1）180 parts by weight goldenrods, 80 parts by weight Herba Andrographitis are fitted into multi-function extractor, are added total equivalent to medicinal material
The water that 10 times of weight decocts 2h, and filtering, collect and add 2 part by weight of cellulose enzymes and total equivalent to medicinal material after filtrate into filter residue again
The water that 8 times of weight filters after 40 DEG C, enzymolysis processing 2h under the conditions of pH5,85 DEG C enzyme deactivation 3min, collects filtrate, will obtain twice
Filtrate merge, be concentrated under reduced pressure into clear cream；
（2）By step（1）Obtained clear cream is squeezed into Alcohol-settling tank, is added 90% ethanol stirring 0.5h, is then stood 48h, filter
Filter vacuum is concentrated under reduced pressure into thick paste afterwards；
（3）By 30 parts by weight Herba Andrographitis powder and 0.5 parts by weight saccharomyces cerevisiae, 0.1 parts by weight Bifidobacterium and 10 parts by weight water
PH is adjusted to 3 after mixing, ferment 24h in 35 DEG C, then in 60 DEG C of drying, is ground to 100 mesh, obtains fermentation Herba Andrographitis powder；
（4）By step（3）Obtained fermentation Herba Andrographitis powder and 1 parts by weight Corn starch, which are added in trough type mixing machine, stirs 10min,
Then step is added（2）Obtained thick paste is stirred for 10min, is pelletized with 14 mesh stainless steel mesh and is sent into the wet granular made
Heated-air circulation oven is dried, then with 40 mesh stainless steel mesh whole grains, the dry particl after whole grain is added 0.6 parts by weight magnesium stearate
0.5h is mixed, capsule is filled, obtains wearing yellow antipyretic capsule after packaging.
The step（1）In the temperature that is concentrated under reduced pressure be 60 DEG C.
The step（1）1.14 when the relative density of middle clear cream is 85 DEG C.
The step（2）The temperature of middle vacuum-concentrcted is 60 DEG C.
The step（2）1.31 when middle thick paste relative density is 60 DEG C.
The saccharomycete, the living bacteria count amount of lactic acid bacteria are 1,000,000,000 CFU/g.
The step（4）Middle drying temperature is 65 DEG C, drying time 3h.
Claims (7)
1. a kind of preparation method for wearing yellow antipyretic capsule, it is characterised in that comprise the following steps：
（1）180-200 parts by weight goldenrod, 80-100 parts by weight Herba Andrographitis are fitted into multi-function extractor, added suitable
2-4h is decocted in 10-15 times of water of medicinal material gross weight, filtering, add 2-2.5 percent by weight fiber into filter residue again after collecting filtrate
Plain enzyme and water of 8-10 times equivalent to medicinal material gross weight the enzymolysis processing 2-4h under the conditions of 40-50 DEG C, pH5-6,85-95 DEG C of enzyme deactivation
Filtered after 3-5min, collect filtrate, the filtrate obtained twice is merged, is concentrated under reduced pressure into clear cream；
（2）By step（1）Obtained clear cream is squeezed into Alcohol-settling tank, is added the ethanol stirring 0.5-1h of 90-95%, is then stood 48-
72h, thick paste is concentrated under reduced pressure into after filtering by filter vacuum；
（3）By 30-40 parts by weight Herba Andrographitis powder and 0.5-1 parts by weight saccharomyces cerevisiae, 0.1-0.15 parts by weight Bifidobacterium and
PH is adjusted to 3-4 after the mixing of 10-15 parts by weight water, ferment 24-48h in 35-45 DEG C, then in 60-80 DEG C of drying, is ground to
100-200 mesh, obtains fermentation Herba Andrographitis powder；
（4）By step（3）Obtained fermentation Herba Andrographitis powder and 1-1.5 parts by weight Corn starch is added in trough type mixing machine and stirred
10-15min, then adds step（2）Obtained thick paste is stirred for 10-15min, is pelletized and incited somebody to action with 14-16 mesh stainless steel mesh
The wet granular that makes is sent into heated-air circulation oven drying, then with 40-60 mesh stainless steel mesh whole grains, the dry particl after whole grain is added
Enter 0.6-0.8 parts by weight magnesium stearate mixing 0.5-1h, fill capsule, obtain wearing yellow antipyretic capsule after packaging.
A kind of 2. preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the step（1）In
The temperature being concentrated under reduced pressure is 60-85 DEG C.
A kind of 3. preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the step（1）In
The 1.14-1.16 when relative density of clear cream is 85 DEG C.
A kind of 4. preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the step（2）In
The temperature of vacuum-concentrcted is 60-80 DEG C.
A kind of 5. preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the step（2）In
1.31-1.35 when thick paste relative density is 60-80 DEG C.
6. a kind of preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the saccharomycete, breast
The living bacteria count amount of sour bacterium is hundred million CFU/g of 10-20.
A kind of 7. preparation method for wearing yellow antipyretic capsule according to claim 1, it is characterised in that the step（4）In
Drying temperature is 65-75 DEG C, drying time 3-4h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711257807.3A CN107961257A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method for wearing yellow antipyretic capsule |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711257807.3A CN107961257A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method for wearing yellow antipyretic capsule |
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| CN107961257A true CN107961257A (en) | 2018-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711257807.3A Pending CN107961257A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method for wearing yellow antipyretic capsule |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660189A (en) * | 2004-12-31 | 2005-08-31 | 王红莲 | Capsule of Chinese traditional medicine for clearing away heat and toxic materia and preparation method |
| CN1679675A (en) * | 2005-01-28 | 2005-10-12 | 北京正大绿洲医药科技有限公司 | Chuanhuang anti-inflammation drops for clearing away heat and detoxicating, and preparation thereof |
-
2017
- 2017-12-04 CN CN201711257807.3A patent/CN107961257A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660189A (en) * | 2004-12-31 | 2005-08-31 | 王红莲 | Capsule of Chinese traditional medicine for clearing away heat and toxic materia and preparation method |
| CN1679675A (en) * | 2005-01-28 | 2005-10-12 | 北京正大绿洲医药科技有限公司 | Chuanhuang anti-inflammation drops for clearing away heat and detoxicating, and preparation thereof |
Non-Patent Citations (3)
| Title |
|---|
| 杨吉霞等: "纤维素酶在中药成分提取中的应用", 《中药材》 * |
| 许明淑等: "酶法强化中药提取的研究进展", 《中国中医药信息杂志》 * |
| 谢莉敏等: "益生菌及其在药学研究中的应用", 《药学研究》 * |
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Application publication date: 20180427 |
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